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Background. The choice of physiotherapeutic method in the treatment of joint diseases remains an urgent problem in physiotherapy. The aim: а comparative study of the effciency of a low-frequency pulsed magnetic feld (LPMF) and its combination with infrared light (photomagnetic therapy) in experimental arthritis. Material and methods. Studies were performed on 50 male rats. A zymosan model of arthritis was used. The animals were divided into 4 groups, the 1st group – intact animals, the 2nd – animals with arthritis without treatment, in the 3rd group they underwent course exposure to LPMF, in the 4th group LPMF in combination with infrared light. Clinical, laboratory, morphological and histochemical studies were performed. Results. It was revealed that photomagnetic therapy to a greater extent than a LPMF reduces the activity of the inflammatory process, and also leads to a partial normalization of the structure of cartilage tissue. Conclusions. The data obtained can be used to develop differentiated methods of physiotherapy in rheumatology.