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Protein arylation has attracted much attention for developing new classes of bioconjugates with improved properties. Here, we have systematically evaluated 2-sulfonylpyrimidines as covalent warheads for the mild, chemoselective and metal free cysteine S-arylation. 2-sulfonylpyrimidines react rapidly with cysteine, resulting in stable S-heteroarylated adducts at neutral pH. Fine tuning the heterocyclic core and exocyclic leaving group allowed predictable SNAr reactivity with model tripeptide glutathione in vitro, covering 9 orders of magnitude. We achieved extremely fast chemo- and regio- specific arylation of a mutant p53 protein, and confirmed arylation sites by protein X-ray crystallography. Hence, we report the first example of a protein site specifically S-arylated with iodo-aromatic motifs. Overall, this study provides the most comprehensive structure-reactivity relationship to date on heteroaryl sulfones, and highlights 2-sulfonylpyrimidine as a synthetically tractable and protein compatible covalent motif for targeting reactive cysteines, expanding the arsenal of tunable warheads for modern covalent ligand discovery.

Invited for this month's cover is the group of Matt O'Brien at Keele University. The cover picture shows a depiction of 'computer vision' in the context of CO

In this paper, we introduce the notions of α -Hermitian–Einstein metric and α -stability for I ± -holomorphic vector bundles on bi-Hermitian manifolds. Moreover, we establish a Kobayashi–Hitchin correspondence for I ± -holomorphic vector bundles on bi-Hermitian manifolds. Examples of such vector bundles include generalized holomorphic bundles on generalized Kahler manifolds. We also show that α -stability of a vector bundle, in this sense, can depend on the parameter α .

This multinational survey investigated the relationship between emotional intelligence (EI) and perceived stress (PS) in seven countries. First-year dental undergraduates attending a dental school in England, Greece, Romania, South Africa, Australia, and the United States and three schools in Malaysia were invited to complete a set of questionnaires on age, gender, academic background, satisfaction with career choice, EI, and PS. Of 860 questionnaires distributed, 596 were fully completed--a response rate of 69.3 percent. Mean EI score was 123.8 (95 percent CI 122.7-124.9), and mean PS score was 19.1 (95 percent CI 18.6-19.7). Significant differences in EI and PS scores were detected between different countries. Females (p

In this paper, we study holomorphic rank-2 vector bundles on non-K\" ahler elliptic surfaces. Our main tool for analysing these bundles is of course the spectral cover. However, given the non-K\"{a}hler condition, the elliptic surfaces we are considering do not have sections and gerbes naturally arise in this context. The spectral construction presented in this paper is a modification of the Fourier-Mukai transform for elliptic fibrations without a section. After examining some of the properties of this Fourier-Mukai transform, we give a complete classification of vector bundles on these surfaces., Comment: 13 pages

In this paper, we study the moduli spaces Open image in new window of stable rank-2 vector bundles on non-Kahler elliptic surfaces, thus giving a classification of these bundles; in the case of Hopf and Kodaira surfaces, these moduli spaces admit the structure of an algebraically completely integrable Hamiltonian system.

The existence problem for vector bundles on a smooth compact complex surface consists in determining which topological complex vector bundles admit holomorphic structures. For projective surfaces, Schwarzenberger proved that a topological complex vector bundle admits a holomorphic (algebraic) structure if and only if its first Chern class belongs to the Neron-Severi group of the surface. In contrast, for non-projective surfaces there is only a necessary condition for the existence problem (the discriminant of the vector bundles must be positive) and the difficulty of the problem resides in the lack of a general method for constructing non-filtrable vector bundles. In this paper, we close the existence problem in the rank-2 case, by giving necessary and sufficient conditions for the existence of holomorphic rank-2 vector bundles on non-K\" ahler elliptic surfaces., Comment: 15 pages, shortened version, corrections were made

A Hopf surface is the quotient of the complex surface by an infinite cyclic group of dilations of . In this paper, we study the moduli spaces of stable -bundles on a Hopf surface , from the point of view of symplectic geometry. An important point is that the surface is an elliptic fibration, which implies that a vector bundle on can be considered as a family of vector bundles over an elliptic curve. We define a map that associates to every bundle on a divisor, called the graph of the bundle, which encodes the isomorphism class of the bundle over each elliptic curve. We then prove that the map G is an algebraically completely integrable Hamiltonian system, with respect to a given Poisson structure on . We also give an explicit description of the fibres of the integrable system. This example is interesting for several reasons; in particular, since the Hopf surface is not Kähler, it is an elliptic fibration that does not admit a section.

To obtain a valid Romanian version of the OHIP-14 for use among Romanian adults, either in Romania or abroad.The Romanian version of the OHIP-14 was obtained through the back translation technique and pre-tested in a pilot study. Subsequently, it was self-administered to 187 adults who also underwent a clinical examination. Cronbach alpha was used to check the internal consistency and reliability analysis and validity tests were used to determine the psychometric properties of the questionnaire.The Cronbach alpha coefficient obtained was 0.88. Inter-item correlation coefficients were between 0.01 and 0.74; item-total correlation values ranged between 0.25 and 0.77. There were statistically significant associations (p= 0.001) between the respondents' self-perceived oral health (r = 0.41), the dental treatment need (r = 0.35) and the mean of the OHIP-14 total scores. Similar statistically significant associations (p= 0.001) existed between the OHIP-14 total scores mean and the clinical data - the number of decayed (D) and of missing (M) teeth and the prosthetic treatment need - proving the construct validity of the questionnaire. The subscales 'physical pain' and 'psychological disability' have the most important impact on the overall OHIP-14 score. The subscales 'social disability' and 'handicap' seem to make the least contribution to the overall OHIP-14 score.The Romanian version of the OHIP-14 is a valid and reliable questionnaire that can be used in future studies.

We prove that any two-dimensional moduli space of stable 2-vector bundles, in the non-filtrable range, on a primary Kodaira surface is a primary Kodaira surface. If a universal bundle exists, then the two surfaces are homeomorphic up to unramified covers., Advances in Mathematics, accepted

New radiographic maxillofacial techniques, cone beam computerized tomography (CBCT) are a necessity in the assessment of jaw bone offer to effectively evaluate the treatment.To quantitatively and qualitatively evaluate anterior mandibular area on CBCT comparing to orthopantomography (OPG).Fifty-one dental patients, aged between 20 and 77 years, were quantitatively analyzed and 81 dental patients, aged between 20 and 79 years, were qualitatively analyzed. ANOVA and Mann-Whitney tests were used for statistical analyses.Strong statistical significant differences were recorded between CBCT and OPG assessments for all groups of teeth (p0.001), when evaluation was performed on distances to mandibular base. When assessing the distance to the incisive canal, the differences were recorded only for the left canine zone. Mean densities of central incisor, lateral incisor and canine regions, were 1,400-1,425 HU, 1,212-1,224 HU, and 1,150-1,175 HU, respectively. There was a marginal statistical evidence that bone density was lower in canine zone comparing to central incisor area (p=0.08).Measurements on CBCT are more accurate when compared with OPG. Bone density of central incisor region is higher. Therefore, CBCT permits the clinician to have all necessary information when planning dental implants.

To determine first year dental students' perceptions of intimidation by instructors and bullying by fellow students.Data were collected through a cross-sectional survey of first year dental students from seven dental schools representing five countries; one each from Romania, South Africa, Australia and the U.S.A., and three from Malaysia. Self-report questionnaires were administered to participants at least six months after they had commenced their dental degree course during 2005-6.Over a third (34.6%) reported that they had been intimidated or badly treated by their tutors/instructors and 17% reported that they had been bullied or badly treated by their fellow students in the recent past. There were statistically significant differences in reports of intimidation by instructors between the different dental schools. Intimidation by instructors was associated with a history of medication use for stress, anxiety and depression, and perceived stress in the past month. There were no statistically significant variations in reports of bullying by fellow students between different dental schools. Bullying by fellow students was associated with dieting to lose weight, self-reported general health and perceived stress.This multi-national study highlights that intimidation and bullying is prevalent within dental teaching and training environments. Future research is needed to explore their impact on students' wellbeing and academic progress as well as on patient care.Dentists are the best recruiters for the profession. If the dental school experience is a negative one it can have significant impact on the future of the profession

It is shown that if $X$ is an Inoue surface of type $S_M$ then the irreducible components of the Douady space of $X^n$ are compact, for all $n>0$. This gives an example of an essentially saturated compact complex manifold (in the sense of model theory) that is not of Kaehler-type. Among the known compact complex surfaces without curves, it is shown that these are the only examples., 10 pages

A hypercomplex manifold is a manifold equipped with three complex structures I, J, K satisfying the quaternionic relations. Let M be a 4-dimensional compact smooth manifold equipped with a hypercomplex structure, and E be a vector bundle on M. We show that the moduli space of anti-self-dual connections on E is also hypercomplex, and admits a strong HKT metric. We also study manifolds with (4,4)-supersymmetry, that is, Riemannian manifolds equipped with a pair of strong HKT-structures that have opposite torsion. In the language of Hitchin's and Gualtieri's generalized complex geometry, (4,4)-manifolds are called ``generalized hyperkaehler manifolds''. We show that the moduli space of anti-self-dual connections on M is a (4,4)-manifold if M is equipped with a (4,4)-structure., 17 pages. Version 3.0: reference added