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Applicative researches in the field of environmental protection like X-ray fluorescence analysis, neutron activation analysis, and other methods, present real increasing importance related to the climate changes that can be observed nowadays. Scientific methods will enter step by step in our life, first of all, due to the accelerated technological development and due to the objective motivations of environmental monitoring necessary to take correct measures for the preservation and protection of nature on the Earth. Determination of some inorganic components, mainly heavy metals, in agricultural crops, is frequently required in health-related environmental studies, due to the high toxicity of trace amounts of such elements for the human organism. The main sources of trace elements to agricrops are their growing media, as soil-water-air ecosystem from which those nutrients are taken up by the root to the foliage. The goal of the present research was to determine the extent to which industrial inorganic pollutants are transferred to the crops. It was achieved by using multielement techniques as photon neutron activation method and X-ray fluorescence methods and statistical modeling in order to determine levels, pathways, and fate of toxic and non-toxic bioactive elements in selected agricrops along with the root soil. Some of the experimental trace metal values exceeded the threshold established by Romanian and EU regulations to protect vegetation and explain the estimated significant crop losses. Multivariate modeling by factor analysis and neural network simulation of the elemental concentration data showed always the component loaded with specific elements coming from industrial emissions. These kinds of studies are very requested regarding the vegetable meant for the human diet.

Background: The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited disease resulting from loss-of-function mutations in ADA2, formerly named CECR1 (cat eye syndrome chromosome region, candidate 1) gene. Disease manifestations could be separated into three major phenotypes: inflammatory/vascular, immune dysregulatory and hematologic, however, most patients presented with significant overlap between these three phenotype groups. Due to its large heterogeneity, DADA2 is often mistaken with other connective tissue diseases. Over 60 DADA2-associated mutations have been identified so far, still we describe a new mutation with possible relation to severe hematological involvement Case presentation: We present a case of DADA2 deficiency with disease onset at 3 years old with fever, oligoarthritis, mouth sores and recurrent episodes of neutropenia misdiagnosed as Behcet disease, then systemic lupus erythematosus. At the age of 18 she developed gastrointestinal vasculitis complicated with multiple bowel resections, enterocutaneous fistulas and lower limb ischemia. Genetic testing reveals heterozygous mutations at positions 139 (exon 2) and 661_664 (exon 4) of the coding sequence of ADA2 (c.139G>A, c.661_664del), resulting respectively in amino acid substitution p.Gly47Arg and premature translational stop signal p.Ala221Glnfs*45 in ADA2. Thus, the patient was diagnosed with ADA2 deficiency. TNF blockers were started but the patient died due to septic complications related to severe, nonresponsive pancytopenia. Conclusions: Our case highlights the valuable diagnostic benefit of early specific genetic testing for patients with complex unclear diseases in which vasculopathy/vasculitis, dysregulated immune function and/or hematologic abnormalities may predominate.

Breast cancer is one of the most severe health issues globally, but the therapy advancements and the constant adaptation of treatment protocols radically changed its prognoses. This article review of the literature from a surgical perspective, thus allowing for the optimum detection and placement of its role and benefits in the surgical and oncology therapeutics. The role of surgery becomes controversial, with sometimes "pretentious" techniques, hard to quantify benefits and challenges that require a thorough assessment prior to opting for surgery. Another interesting aspect is the relative lack of guidelines for such cases with an extreme lesion plurimorphism. This is the very reason for the term "advanced breast cancer" NOT covering all possible situations, leaving room for niches difficult to frame within a therapy plan.

The paper aims to analyze the main legal rules governing the operation of forms of association that have arisen since 1990 in the Romanian agriculture. For optimization of the comparative analysis methods the study focuses on four regulations, representative in the forms of association evolution. They are presented in chronological order: "Law no. 36/1991 regarding the agricultural companies and other agricultural associations" representing the first piece of legislation that enacted the association, "Ordinance No 26/2000 regarding associations and foundation", representing the second stage, "Agricultural cooperatives law No. 566” issued on December 9, 2004 and "Ordinance no. 37/2005 regarding the recognition and operation of the producer groups", due to Romania's pre-accession phase to the European Union. The results of this study establish first how the areas of agricultural activity were influenced by some legal details present in the legislation and on the other side identifies form of association which best matches the requirements imposed by the development of the agricultural products. It can be concluded that in terms of the concept of sustainable rural development, democratic association of agricultural cooperatives is the best alternative for Romanian farmers.