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2. Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants: Exposome-Wide Analysis and Mendelian Randomization Analysis

Author

Lin, B.D., Pries, L.K., Sarac, H.S., van Os, J., Rutten, B.P.F., Luykx, J., Guloksuz, S., Psychiatry 1, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, and MUMC+: MA Psychiatrie (3)

Subjects
RISK, Male, ENVIRONMENT, SYMPTOMS, DISORDERS, BEHAVIORS, Mendelian Randomization Analysis, Middle Aged, PREVENTION, Polymorphism, Single Nucleotide, CANNABIS USE, United Kingdom, Cohort Studies, Psychiatry and Mental health, Exposome, SCHIZOPHRENIA, Humans, Female, MENTAL-HEALTH, METAANALYSIS, Biological Specimen Banks, Genome-Wide Association Study
Abstract

IMPORTANCE Although hypothesis-driven research has identified several factors associated with psychosis, this one-exposure-to-one-outcome approach fails to embrace the multiplicity of exposures. Systematic approaches, similar to agnostic genome-wide analyses, are needed to identify genuine signals.OBJECTIVE To systematically investigate nongenetic correlates of psychotic experiences through data-driven agnostic analyses and genetically informed approaches to evaluate associations.DESIGN, SETTING, PARTICIPANTS This cohort study analyzed data from the UK Biobank Mental Health Survey from January 1 to June 1, 2021. An exposome-wide association study was performed in 2 equal-sized split discovery and replication data sets. Variables associated with psychotic experiences in the exposome-wide analysis were tested in a multivariable model. For the variables associated with psychotic experiences in the final multivariable model, the single-nucleotide variant-based heritability and genetic overlap with psychotic experiences using linkage disequilibrium score regression were estimated, and mendelian randomization (MR) approaches were applied to test potential causality. The significant associations observed in 1-sample MR analyses were further tested in multiple sensitivity tests, including collider-correction MR, 2-sample MR, and multivariable MR analyses.EXPOSURES After quality control based on a priori criteria, 247 environmental, lifestyle, behavioral, and economic variables.MAIN OUTCOMES AND MEASURES Psychotic experiences.RESULTS The study included 155 247 participants (87 896 [57%) female; mean [SD] age, 55.94 [7.74] years). In the discovery data set, 162 variables (66%) were associated with psychotic experiences. Of these, 148 (91%) were replicated. The multivariable analysis identified 36 variables that were associated with psychotic experiences. Of these, 28 had significant genetic overlap with psychotic experiences. One-sample MR analyses revealed forward associations with 3 variables and reverse associations with 3. Forward associations with ever having experienced sexual assault and pleiotropy of risk-taking behavior and reverse associations without pleiotropy of experiencing a physically violent crime as well as cannabis use and the reverse association with pleiotropy of worrying too long after embarrassment were confirmed in sensitivity tests. Thus, associations with psychotic experiences were found with both well-studied and unexplored multiple correlated variables. For several variables, the direction of the association was reversed in the final multivariable and MR analyses.CONCLUSIONS AND RELEVANCE The findings of this study underscore the need for systematic approaches and triangulation of evidence to build a knowledge base from ever-growing observational data to guide population-level prevention strategies for psychosis.

Published
2023

3. The need for a diagnostic instrument to assess post-traumatic stress disorder in people with dementia: Findings from a Delphi Study

Author

Havermans, D.C.D., van Alphen, Bas, Olff, M., van der Velden-Daamen, M., Verhey, F., Rutten, B.P.F., Stuijts, P., Cook, J.M., Sobczak, S., Havermans, D.C.D., van Alphen, Bas, Olff, M., van der Velden-Daamen, M., Verhey, F., Rutten, B.P.F., Stuijts, P., Cook, J.M., and Sobczak, S.

Abstract

Cognitive and behavioral aspects may mask posttraumatic stress disorder (PTSD) in people with dementia. PTSD severely lowers quality of life in people with dementia. Proper recognition of PTSD is essential to ensure adequate treatment. However, a valid diagnostic tool for PTSD in dementia is lacking. A Delphi study was conducted among 20 Dutch and 6 international experts in the field of PTSD and dementia care or research. The aim was to reach consensus in 3 rounds on the added value, form, content, and application for developing such an instrument. The first round confirmed the need for a new diagnostic tool for research and clinical practice. Consensus was reached on 23 statements regarding the support base and 19 related to content of the instrument. In the third round, opinions on several conceptual problems were gathered. Based on the experts' opinions, a draft version of an instrument, the TRAuma and DEmentia-interview (TRADE-interview), was developed. Clinical and research implications of this new measure are discussed.

Published
2023

4. Impact of adverse childhood experiences on educational achievements in young people at clinical high risk of developing psychosis

Author

Tognin, S., Catalan, A., Kempton, M.J., Nelson, B., McGorry, P., Riecher-Rossler, A., Bressan, R., Barrantes-Vidal, N., Krebs, M.O., Nordentoft, M., Ruhrmann, S., Sachs, G., Rutten, B.P.F., van Os, J., de Haan, L., van der Gaag, M., McGuire, P., Valmaggia, L.R., RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, and MUMC+: MA Psychiatrie (3)

Subjects
education, EMOTION RECOGNITION, ADULTS, clinical high risk for psychosis, Psychiatry and Mental health, INDIVIDUALS, ULTRA-HIGH RISK, SCHOOL, ACADEMIC-ACHIEVEMENT, EMPLOYMENT, Adverse childhood experiences, PROTECTIVE FACTORS, MENTAL-HEALTH, TRAUMA
Abstract

Background Adverse childhood experiences (ACE) can affect educational attainments, but little is known about their impact on educational achievements in people at clinical high risk of psychosis (CHR). Methods In total, 344 CHR individuals and 67 healthy controls (HC) were recruited as part of the European Community’s Seventh Framework Programme-funded multicenter study the European Network of National Schizophrenia Networks Studying Gene–Environment Interactions (EU-GEI). The brief version of the Child Trauma Questionnaire was used to measure ACE, while educational attainments were assessed using a semi-structured interview. Results At baseline, compared with HC, the CHR group spent less time in education and had higher rates of ACE, lower rates of employment, and lower estimated intelligence quotient (IQ). Across both groups, the total number of ACE was associated with fewer days in education and lower level of education. Emotional abuse was associated with fewer days in education in HC. Emotional neglect was associated with a lower level of education in CHR, while sexual abuse was associated with a lower level of education in HC. In the CHR group, the total number of ACE, physical abuse, and neglect was significantly associated with unemployment, while emotional neglect was associated with employment. Conclusions ACE are strongly associated with developmental outcomes such as educational achievement. Early intervention for psychosis programs should aim at integrating specific interventions to support young CHR people in their educational and vocational recovery. More generally, public health and social interventions focused on the prevention of ACE (or reduce their impact if ACE occur) are recommended.

Published
2023

7. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway

Author

van Os, J., van Os, J., Pries, L.K., ten Have, M., de Graaf, R., van Dorsselaer, S., Delespaul, P., Bak, M., Kenis, G., Lin, B.D., Luykx, J.J., Richards, A.L., Akdede, B., Binbay, T., Altinyazar, V., Yalincetin, B., Gumus-Akay, G., Cihan, B., Soygur, H., Ulas, H., Cankurtaran, E.S., Kaymak, S.U., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Bernardo, M., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., Garcia-Portilla, M.P., Sanjuan, J., Aguilar, E.J., Santos, J.L., Jimenez-Lopez, E., Arrojo, M., Carracedo, A., Lopez, G., Gonzalez-Penas, J., Parellada, M., Maric, N.P., Atbasoglu, C., Ucok, A., Alptekin, K., Saka, M.C., Arango, C., O'Donovan, M., Rutten, B.P.F., Guloksuz, S., van Os, J., van Os, J., Pries, L.K., ten Have, M., de Graaf, R., van Dorsselaer, S., Delespaul, P., Bak, M., Kenis, G., Lin, B.D., Luykx, J.J., Richards, A.L., Akdede, B., Binbay, T., Altinyazar, V., Yalincetin, B., Gumus-Akay, G., Cihan, B., Soygur, H., Ulas, H., Cankurtaran, E.S., Kaymak, S.U., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Bernardo, M., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., Garcia-Portilla, M.P., Sanjuan, J., Aguilar, E.J., Santos, J.L., Jimenez-Lopez, E., Arrojo, M., Carracedo, A., Lopez, G., Gonzalez-Penas, J., Parellada, M., Maric, N.P., Atbasoglu, C., Ucok, A., Alptekin, K., Saka, M.C., Arango, C., O'Donovan, M., Rutten, B.P.F., and Guloksuz, S.

Abstract

Background There is evidence that environmental and genetic risk factors for schizophrenia spectrum disorders are transdiagnostic and mediated in part through a generic pathway of affective dysregulation. Methods We analysed to what degree the impact of schizophrenia polygenic risk (PRS-SZ) and childhood adversity (CA) on psychosis outcomes was contingent on co-presence of affective dysregulation, defined as significant depressive symptoms, in (i) NEMESIS-2 (n = 6646), a representative general population sample, interviewed four times over nine years and (ii) EUGEI (n = 4068) a sample of patients with schizophrenia spectrum disorder, the siblings of these patients and controls. Results The impact of PRS-SZ on psychosis showed significant dependence on co-presence of affective dysregulation in NEMESIS-2 [relative excess risk due to interaction (RERI): 1.01, p = 0.037] and in EUGEI (RERI = 3.39, p = 0.048). This was particularly evident for delusional ideation (NEMESIS-2: RERI = 1.74, p = 0.003; EUGEI: RERI = 4.16, p = 0.019) and not for hallucinatory experiences (NEMESIS-2: RERI = 0.65, p = 0.284; EUGEI: -0.37, p = 0.547). A similar and stronger pattern of results was evident for CA (RERI delusions and hallucinations: NEMESIS-2: 3.02, p < 0.001; EUGEI: 6.44, p < 0.001; RERI delusional ideation: NEMESIS-2: 3.79, p < 0.001; EUGEI: 5.43, p = 0.001; RERI hallucinatory experiences: NEMESIS-2: 2.46, p < 0.001; EUGEI: 0.54, p = 0.465). Conclusions The results, and internal replication, suggest that the effects of known genetic and non-genetic risk factors for psychosis are mediated in part through an affective pathway, from which early states of delusional meaning may arise.

Published
2022

8. Lower Emotional Complexity as a Prospective Predictor of Psychopathology in Adolescents From the General Population

Author

Schreuder, Marieke J., Wichers, M., Hartman, C.A., Menne-Lothmann, C., Decoster, J., van Winkel, R., Delespaul, P., De Hert, M., Derom, C., Thiery, E., Rutten, B.P.F., Jacobs, N., van Os, J., Wigman, J.T.W., Schreuder, Marieke J., Wichers, M., Hartman, C.A., Menne-Lothmann, C., Decoster, J., van Winkel, R., Delespaul, P., De Hert, M., Derom, C., Thiery, E., Rutten, B.P.F., Jacobs, N., van Os, J., and Wigman, J.T.W.

Abstract

Emotional complexity (EC) involves the ability to distinguish between distinct emotions (differentiation) and the experience of a large range of emotions (diversity). Lower EC has been related to psychopathology in cross-sectional studies. This study aimed to investigate (a) whether EC prospectively predicts psychopathology and (b) whether this effect is contingent on stressful life events. To further explore EC, we compared the effects of differentiation and diversity. Adolescents from the general population (N = 401) rated 8 negatively valenced emotions 10 times a day for 6 consecutive days. Further, they completed the Symptom Checklist-90 (baseline and 1-year follow-up) and a questionnaire on past year's life events at follow-up. Logistic regression analyses tested whether EC-reflected by emotion differentiation (intraclass correlation coefficient [ICC]) and diversity (diversity index [DI])-predicted prognosis (good: remitting or lacking symptoms vs. bad: worsening or persisting symptoms). EC predicted prognoses but only when based on the ICC (OREC.ICC = 1.42, p = .02). An ECICC 1 SD above average increased the probability of good prognosis from .67 to .74. This effect was not related to stressful life events (OREC x Life events = 1.03, p = .86) and disappeared when emotion intensity (mean level) was taken into account (OREC = 1.20, p = .20). Predicting future prognosis does not necessitate complex measures of emotional experience (ICC, DI) but rather might be achieved through simpler indices (mean). The discrepant effects of the ICC and DI on prognosis suggest that impaired emotion representation (ICC) plays a more important role in vulnerability to mental ill health than does low diversity of emotions (DI).

Published
2022

9. Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression

Author

van der Zee, Y.Y., Eijssen, L.M.T., Mews, P., Ramakrishnan, A., Alvarez, K., Lardner, C.K., Cates, H.M., Walker, D.M., Torres-Berrio, A., Browne, C.J., Cunningham, A., Cathomas, F., Kronman, H., Parise, E.M., de Nijs, L., Shen, L., Murrough, J.W., Rutten, B.P.F., Nestler, E.J., Issler, O., van der Zee, Y.Y., Eijssen, L.M.T., Mews, P., Ramakrishnan, A., Alvarez, K., Lardner, C.K., Cates, H.M., Walker, D.M., Torres-Berrio, A., Browne, C.J., Cunningham, A., Cathomas, F., Kronman, H., Parise, E.M., de Nijs, L., Shen, L., Murrough, J.W., Rutten, B.P.F., Nestler, E.J., and Issler, O.

Abstract

Major depressive disorder (MDD) is the leading cause of disability worldwide. There is an urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome, assign treatment, and evaluate treatment response and prognosis. MicroRNAs (miRNAs) are short non-coding RNAs, which are detected in body fluids that have emerged as potential biomarkers of many disease conditions. The present study explored the potential use of miRNAs as biomarkers for MDD and its treatment. We profiled the expression levels of circulating blood miRNAs from mice that were collected before and after exposure to chronic social defeat stress (CSDS), an extensively validated mouse model used to study depression, as well as after either repeated imipramine or single-dose ketamine treatment. We observed robust differences in blood miRNA signatures between stress-resilient and stress-susceptible mice after an incubation period, but not immediately after exposure to the stress. Furthermore, ketamine treatment was more effective than imipramine at re-establishing baseline miRNA expression levels, but only in mice that responded behaviorally to the drug. We identified the red blood cell-specific miR-144-3p as a candidate biomarker to aid depression diagnosis and predict ketamine treatment response in stress-susceptible mice and MDD patients. Lastly, we demonstrate that systemic knockdown of miR-144-3p, via subcutaneous administration of a specific antagomir, is sufficient to reduce the depression-related phenotype in stress-susceptible mice. RNA-sequencing analysis of blood after such miR-144-3p knockdown revealed a blunted transcriptional stress signature as well. These findings identify miR-144-3p as a novel target for diagnosis of MDD as well as for antidepressant treatment, and enhance our understanding of epigenetic processes associated with depression.

Published
2022

10. Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants Exposome-Wide Analysis and Mendelian Randomization Analysis

Author

Lin, B.D., Pries, L.K., Sarac, H.S., van Os, J., Rutten, B.P.F., Luykx, J., Guloksuz, S., Lin, B.D., Pries, L.K., Sarac, H.S., van Os, J., Rutten, B.P.F., Luykx, J., and Guloksuz, S.

Abstract

IMPORTANCE Although hypothesis-driven research has identified several factors associated with psychosis, this one-exposure-to-one-outcome approach fails to embrace the multiplicity of exposures. Systematic approaches, similar to agnostic genome-wide analyses, are needed to identify genuine signals.OBJECTIVE To systematically investigate nongenetic correlates of psychotic experiences through data-driven agnostic analyses and genetically informed approaches to evaluate associations.DESIGN, SETTING, PARTICIPANTS This cohort study analyzed data from the UK Biobank Mental Health Survey from January 1 to June 1, 2021. An exposome-wide association study was performed in 2 equal-sized split discovery and replication data sets. Variables associated with psychotic experiences in the exposome-wide analysis were tested in a multivariable model. For the variables associated with psychotic experiences in the final multivariable model, the single-nucleotide variant-based heritability and genetic overlap with psychotic experiences using linkage disequilibrium score regression were estimated, and mendelian randomization (MR) approaches were applied to test potential causality. The significant associations observed in 1-sample MR analyses were further tested in multiple sensitivity tests, including collider-correction MR, 2-sample MR, and multivariable MR analyses.EXPOSURES After quality control based on a priori criteria, 247 environmental, lifestyle, behavioral, and economic variables.MAIN OUTCOMES AND MEASURES Psychotic experiences.RESULTS The study included 155 247 participants (87 896 [57%) female; mean [SD] age, 55.94 [7.74] years). In the discovery data set, 162 variables (66%) were associated with psychotic experiences. Of these, 148 (91%) were replicated. The multivariable analysis identified 36 variables that were associated with psychotic experiences. Of these, 28 had significant genetic overlap with psychotic experiences. One-sample MR analyses revealed forward associatio

Published
2022

12. The search for an autoimmune origin of psychotic disorders: Prevalence of autoantibodies against hippocampus antigens, glutamic acid decarboxylase and nuclear antigens

Author

Hoffmann, C. (Carolin), Zong, S. (Shenghua), Mané-Damas, M. (Marina), Stevens, J. (Jo), Malyavantham, K. (Kishore), Küçükali, C.İ. (Cem İsmail), Tüzün, E. (Erdem), Hert, M. (Marc) de, Beveren, N.J.M. (Nico) van, González-Vioque, E. (Emiliano), Arango, C. (Celso), Damoiseaux, J., Rutten, B.P.F., Molenaar, P.C. (Peter C.), Losen, M. (Mario), Martínez-Martínez, P. (Pilar), Hoffmann, C. (Carolin), Zong, S. (Shenghua), Mané-Damas, M. (Marina), Stevens, J. (Jo), Malyavantham, K. (Kishore), Küçükali, C.İ. (Cem İsmail), Tüzün, E. (Erdem), Hert, M. (Marc) de, Beveren, N.J.M. (Nico) van, González-Vioque, E. (Emiliano), Arango, C. (Celso), Damoiseaux, J., Rutten, B.P.F., Molenaar, P.C. (Peter C.), Losen, M. (Mario), and Martínez-Martínez, P. (Pilar)

Abstract

The etiology of psychotic disorders is still unknown, but in a subgroup of patients symptoms might be caused by an autoimmune reaction. In this study, we tested patterns of autoimmune reactivity against potentially novel hippocampal antigens. Serum of a cohort of 621 individuals with psychotic disorders and 257 controls were first tested for reactivity on neuropil of rat brain sections. Brain reactive sera (67 diseased, 27 healthy) were further tested for antibody binding to glutamic acid decarboxylase (GAD) isotype 65 and 67 by cell-based assay (CBA). A sub-cohort of 199 individuals with psychotic disorders and 152 controls was tested for the prevalence of anti-nuclear antibodies (ANA) on HEp2-substrate as well as for reactivity to double-stranded DNA, ribosomal P (RPP), and cardiolipin (CL). Incubation of rat brain with serum resulted in unidentified hippocampal binding patterns in both diseased and control groups. Upon screening with GAD CBA, one of these patterns was identified as GAD65 in one individual with schizophrenia and also in one healthy individual. Two diseased and two healthy individuals had low antibody levels targeting GAD67 by CBA. Antibody reactivity on HEp-2-substrate was increased in patients with schizoaffective disorder, but only in 3 patients did antibody testing hint at a possible diagnosis of systemic lupus erythematosus. Although reactivity of serum to intracellular antigens might be increased in patients with psychotic disorder, no specific targets could be identified. GAD antibodies are very rare and do not seem increased in serum of patients with psychotic disorders.

Published
2021
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13. The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study

Author

Pignon, B., Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.R., Baudin, G., Tosato, S., Jongsma, H., de Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuan, J., Selten, J.P., Tortelli, A., Llorca, P.M., van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szoke, A., Schurhoff, F., Pignon, B., Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.R., Baudin, G., Tosato, S., Jongsma, H., de Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuan, J., Selten, J.P., Tortelli, A., Llorca, P.M., van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szoke, A., and Schurhoff, F.

Abstract

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment-environment (ExE) interactions between these factors. Data were drawn from the EUGEI study, in which healthy controls (N = 1497) and siblings of subjects with a psychotic disorder (N = 265) were included in six countries. The association between psychosocial stressors and subclinical psychosis dimensions (positive, negative and depressive dimension as measured by the Community Assessment of Psychic Experiences (CAPE) scale) and possible ExE interactions were assessed using linear regression models. After adjusting for sex, age, ethnicity, country, and control/sibling status, childhood trauma (beta for positive dimension: 0.13, negative: 0.49, depressive: 0.26) and stressful life events (positive: 0.08, negative: 0.16, depressive: 0.17) were associated with the three dimensions. Lower social capital was associated with the negative and depression dimensions (negative: 0.26, depressive: 0.13), and self-reported discrimination experiences with the positive dimension (0.06). Our findings are in favor of independent, cumulative and non-specific influences of social adversities in subclinical psychosis in non-clinical populations, without arguments for E x E interactions.

Published
2021

14. The main and interactive effects of adult stressful life events with genomic and exposomic liability for schizophrenia on mental and physical health: a prospective cohort study

Author

Pries, Lotta-Katrin, ten Have, M., de Graaf, R., van Dorsselaer, S., Bak, M., Geurts - Gunther, N.C.H.F., Li, B.D., Luykx, J.J., Rutten, B.P.F., van Os, Jim, Guloksuz, S., Department of Clinical Psychology, and RS-Research Line Clinical psychology (part of IIESB program)

Abstract

Background Evidence suggests that the impact of adult stressful life events (SLE) on health depends on an individual’s environmental and genetic predisposition to psychopathology. However, the influence of the genomic and exposomic (the sum of exposures) liabilities for schizophrenia on the association between SLE and health outcomes in the general population has not been studied. The current longitudinal study therefore aims to evaluate whether the association of recent SLE with mental as well as physical health is moderated by polygenic risk score for schizophrenia (PRS-S) and the exposome score for schizophrenia (ES-S, an aggregated environmental exposure score, akin to PRS-S). Methods Data from four waves of the Netherlands Mental Health Survey and Incidence Study-II (NEMESIS-II), a prospective survey in the Dutch general population aged 18 – 64, was used. The baseline data (T0) of NEMESIS-II, including 6646 participants, were collected from 2007 to 2009 and were followed up at year 3 (T1), year 6 (T2), and year 9 (T3). The Short-Form-36 Health Survey was used to repeatedly assess mental and physical health. Repeated assessment of SLE were based on the Brugha Life events section. Guided by our previous work, ES-S was constructed as the weighted sum of important baseline environmental factors, which were previously associated with schizophrenia. A subsample of 3099 participants (at T0) were genotyped and PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis, adjusted for the first three population principal components. The analyses were conducted using random intercept multilevel regression models with age, sex, and education included as a priori covariates. Models were clustered for multiple assessments per individual, and the random intercept of mental or physical health at T-1 was added to the model to control for previous health status. We evaluated the main effects of SLE, ES-S, and PRS-S, and tested the moderating effects of ES-S and PRS-S on the impact of SLE on physical and mental health. As sensitivity analyses, we repeated the analyses using lagged SLE at T-1. Results SLE and ES-S were associated with decreased mental (SLE: β = -2.53, P

Published
2020
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15. MicroRNA regulation of persistent stress-enhanced memory (vol 25, pg 965, 2019)

Author

Sillivan, S.E., Jamieson, S., Nijs, L. de, Jones, M., Snijders, C., Klengel, T., Joseph, N.F., Krauskopf, J., Kleinjans, J., Vinkers, C.H., Boks, M.P.M., Geuze, E., Vermetten, E., Berretta, S., Ressler, K.J., Rutten, B.P.F., Rumbaugh, G., and Miller, C.A.

Subjects
Hardware_INTEGRATEDCIRCUITS, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Hardware_PERFORMANCEANDRELIABILITY, GeneralLiterature_MISCELLANEOUS
Abstract

A correction to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

16. Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study

Author

Thygesen, J.H. (Johan H.), Presman, A. (Amelia), Harju-Seppänen, J. (Jasmine), Irizar, H. (Haritz), Jones, R. (Rebecca), Kuchenbaecker, K.B. (Karoline), Lin, K. (Kuang), Alizadeh, B.Z. (Behrooz), Austin-Zimmerman, I. (Isabelle), Bartels-Velthuis, A. (Agna), Bhat, A. (Anjali), Bruggeman, R. (Richard), Cahn, W. (Wiepke), Calafato, S. (Stella), Crespo-Facorro, B. (Benedicto), de Haan, L. (Liewe), de Zwarte, S.M.C. (Sonja M. C.), Di Forti, M. (Marta), Díez-Revuelta, Á. (Álvaro), Hall, J. (Jeremy), Hall, M.-H. (Mei-Hua), Iyegbe, C. (Conrad), Jablensky, A. (Assen), Kahn, R. (René), Kalaydjieva, L. (Luba), Kravariti, E. (Eugenia), Lawrie, S. (Stephen), Luykx, J.J. (Jurjen J.), Mata, I. (Igancio), McDonald, C. (Colm), McIntosh, A.M. (Andrew), McQuillin, A. (Andrew), Muir, R. (Rebecca), Ophoff, R.A. (Roel), Picchioni, M. (Marco), Prata, D.P. (Diana P.), Ranlund, S. (Siri), Rujescu, D. (Dan), Rutten, B.P.F., Schulze, K. (Katja), Shaikh, M. (Madiha), Schirmbeck, F. (Frederike), Simons, C.J.P. (Claudia J. P.), Toulopoulou, T. (Timothea), Amelsvoort, T.A.M.J. (Therese) van, van Haren, N. (Neeltje), Os, J. (Jim) van, van Winkel, R. (Ruud), Vassos, E. (Evangelos), Walshe, M. (Muriel), Weisbrod, M. (Matthias), Zartaloudi, E. (Eirini), Bell, V. (Vaughan), Powell, J. (John), Lewis, C.M. (Cathryn), Murray, R.M. (Robin M.), Bramon, E. (Elvira), Thygesen, J.H. (Johan H.), Presman, A. (Amelia), Harju-Seppänen, J. (Jasmine), Irizar, H. (Haritz), Jones, R. (Rebecca), Kuchenbaecker, K.B. (Karoline), Lin, K. (Kuang), Alizadeh, B.Z. (Behrooz), Austin-Zimmerman, I. (Isabelle), Bartels-Velthuis, A. (Agna), Bhat, A. (Anjali), Bruggeman, R. (Richard), Cahn, W. (Wiepke), Calafato, S. (Stella), Crespo-Facorro, B. (Benedicto), de Haan, L. (Liewe), de Zwarte, S.M.C. (Sonja M. C.), Di Forti, M. (Marta), Díez-Revuelta, Á. (Álvaro), Hall, J. (Jeremy), Hall, M.-H. (Mei-Hua), Iyegbe, C. (Conrad), Jablensky, A. (Assen), Kahn, R. (René), Kalaydjieva, L. (Luba), Kravariti, E. (Eugenia), Lawrie, S. (Stephen), Luykx, J.J. (Jurjen J.), Mata, I. (Igancio), McDonald, C. (Colm), McIntosh, A.M. (Andrew), McQuillin, A. (Andrew), Muir, R. (Rebecca), Ophoff, R.A. (Roel), Picchioni, M. (Marco), Prata, D.P. (Diana P.), Ranlund, S. (Siri), Rujescu, D. (Dan), Rutten, B.P.F., Schulze, K. (Katja), Shaikh, M. (Madiha), Schirmbeck, F. (Frederike), Simons, C.J.P. (Claudia J. P.), Toulopoulou, T. (Timothea), Amelsvoort, T.A.M.J. (Therese) van, van Haren, N. (Neeltje), Os, J. (Jim) van, van Winkel, R. (Ruud), Vassos, E. (Evangelos), Walshe, M. (Muriel), Weisbrod, M. (Matthias), Zartaloudi, E. (Eirini), Bell, V. (Vaughan), Powell, J. (John), Lewis, C.M. (Cathryn), Murray, R.M. (Robin M.), and Bramon, E. (Elvira)

Abstract

The burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia. Several cognitive measures are purported schizophrenia endophenotypes and may represent an intermediate point between genetics and the illness. This paper investigates the influence of CNVs on cognition. We conducted a systematic review and meta-analysis of the literature exploring the effect of CNV burden on general intelligence. We included ten primary studies with a total of 18,847 participants and found no evidence of association. In a new psychosis family study, we investigated the effects of CNVs on specific cognitive abilities. We examined the burden of large and rare CNVs (>200 kb, <1% MAF) as well as known schizophrenia-associated CNVs in patients with psychotic disorders, their unaffected relatives and controls (N = 3428) from the Psychosis Endophenotypes International Consortium (PEIC). The carriers of specific schizophrenia-associated CNVs showed poorer performance than non-carriers in immediate (P = 0.0036) and delayed (P = 0.0115) verbal recall. We found suggestive evidence that carriers of schizophrenia-associated CNVs had poorer block design performance (P = 0.0307). We do not find any association between CNV burden and cognition. Our findings show that the known high-risk CNVs are not only associated with schizophrenia and other neurodevelopmental disorders, but are also a contributing factor to impairment in cognitive domains such as memory and perceptual reasoning, and act as intermediate biomarkers of disease risk.

Published
2020
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18. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Author

Schijven, D., Chen, C.-Y., Morey, R.A., Vermetten, E., Sanchez, S.E., Maihofer, A.X., Jett, M., Dale, A.M., Ratanatharathorn, A., McGlinchey, R.E., McLaughlin, K.A., Polimanti, R., Roberts, A.L., Williams, M.A., Nievergelt, C.M., Atkinson, E.G., Mors, O., Brashear, M., Gordon, S.D., Trapido, E., Haas, M., Lawford, B.R., Kimbrel, N.A., Sponheim, S.R., Daskalakis, N.P., Duncan, L.E., Rung, A., Orcutt, H.K., Pietrzak, R.H., Bustamante, A.C., Bisson, J.I., Koenen, K.C., McLean, S.A., Ripke, S., Kremen, W.S., Maples-Keller, J., Marmar, C., Sheerin, C.M., Calabrese, J.R., Andersen, S.B., Seligowski, A.V., Feeny, N.C., Polusny, M.A., Qin, X.-J., Daly, M.J., Ashley-Koch, A.E., Morris, C.P., Liberzon, I., Erbes, C.R., King, A.P., Zhao, H., Forbes, D., Jakovljevic, M., van den Heuvel, L.L., Peters, E.S., Evans, A., Boks, M.P., Aiello, A.E., Hougaard, D.M., Roy-Byrne, P., Bierut, L.J., Kranzler, H.R., Vinkers, C.H., Peterson, A.L., Wolf, C., Deckert, J., Linnstaedt, S.D., Stein, D.J., Levey, D.F., Almli, L.M., Martin, N.G., Williamson, D.E., Flory, J.D., Børglum, A.D., Guffanti, G., Stein, M.B., Lori, A., Khan, A., Baker, D.G., Ressler, K.J., Torres, K., Seedat, S., Andreassen, O.A., Neale, B.M., Werge, T., Mehta, D., Austin, S.B., Breen, G., Beckham, J.C., Geuze, E., Miller, M.W., Mortensen, P.B., Coleman, J.R.I., Provost, A.C., Norman, S.B., Garrett, M.E., McLeay, S., Van Hooff, M., Bolger, E.A., Franz, C.E., Luykx, J.J., Maurer, D., Wolff, J.D., Martin, A.R., Young, K.A., Lewis, C.E., Zoellner, L.A., Dennis, M.F., Delahanty, D.L., O’Donnell, M., Heath, A.C., Saccone, N.L., Domschke, K., Logue, M.W., Ursano, R.J., Smith, A.K., Rothbaum, A.O., Rutten, B.P.F., Harnal, S., Panizzon, M.S., Uddin, M., Babiat, D., Bryant, R.A., Gelernter, J., Smoller, J.W., Klengel, T., Bybjerg-Grauholm, J., Choi, K.W., Jovanovic, T., Caldas-de-Almeida, J.M., Nelson, E.C., Mavissakalian, M.R., Johnson, E.O., Hammamieh, R, Milberg, W.P., Nordentoft, M., Gillespie, C., Amstadter, A.B., Bradley, B., Teicher, M.H., Arbisi, P.A., Lebois, L.A.M., Hauser, M.A., Dzubur-Kulenovic, A., Hemmings, S.M.J., Gelaye, B., Sumner, J.A., Uka, A.G., Young, R.M.D., Voisey, J., Wang, Y., Galea, S., Wang, Z., Jones, I., Peverill, M., Disner, S.G., Seng, J.S., Kessler, R.C., Junglen, A.G., Wolf, E.J., Lugonja, B., Dalvie, S., Koen, N., Rice, J.P., Rothbaum, B.O., Thompson, W.K., Ruggiero, K., Karstoft, K.-I., Farrer, L.A., Stevens, J.S., Silove, D., Avdibegovic, E., Risbrough, V.B., Lyons, M.J., Bækvad-Hansen, M., and McFarlane, A.

Abstract

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations. © 2019, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

Published
2019
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19. NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons

Author

Vaes, N., Lentjes, M.H.F.M., Gijbels, M.J., Rademakers, G., Daenen, K.L., Boesmans, W. (Werend), Wouters, K.A.D., Geuzens, A., Qu, X., Steinbusch, H.P.J., Rutten, B.P.F., Baldwin, S.H., Sharkey, K.A., Hofstra, R.M.W. (Robert), Engeland, M. (Manon) van, Vanden Berghe, P., Melotte, V. (Veerle), Vaes, N., Lentjes, M.H.F.M., Gijbels, M.J., Rademakers, G., Daenen, K.L., Boesmans, W. (Werend), Wouters, K.A.D., Geuzens, A., Qu, X., Steinbusch, H.P.J., Rutten, B.P.F., Baldwin, S.H., Sharkey, K.A., Hofstra, R.M.W. (Robert), Engeland, M. (Manon) van, Vanden Berghe, P., and Melotte, V. (Veerle)

Abstract

Background: Promoter methylation of N-myc Downstream-Regulated Gene 4 (NDRG4) in fecal DNA is an established early detection marker for colorectal cancer (CRC). Despite its connection to CRC, NDRG4 is predominantly studied in brain and heart, with little to no knowledge about its expression or role in other organs. In this study, we aimed to determine the whole-body expression of NDRG4, with a focus on the intestinal tract. Methods: We investigated NDRG4 expression throughout the body by immunohistochemistry, Western Blotting and in situ mRNA hybridization using tissues from NDRG4 wild-type, heterozygous and knockout mice and humans. In addition, we explored cell-specific expression of NDRG4 in murine whole-mount gut preparations using immunofluorescence and confocal microscopy. Key Results: NDRG4 is specifically expressed within nervous system structures throughout the body. In the intestinal tract of both mouse and man, NDRG4 immunoreactivity was restricted to the enteric nervous system (ENS), where it labeled cell bodies of the myenteric and submucosal plexuses and interconnecting nerve fibers. More precisely, NDRG4 expression was limited to neurons, as NDRG4 always co-localized with HuC/D (pan-neuronal marker) but never wi

Published
2017
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20. The resilience framework as a strategy to combat stress-related disorders

Author

Kalisch, R., Baker, D.G., Basten, U., Boks, M.P.M., Bonanno, G.A., Brummelman, E., Chmitorz, A., Fernandez, G.S.E., Fiebach, C.J., Galatzer-Levy, I.R., Geuze, E., Groppa, S., Helmreich, I., Hendler, T., Hermans, E.J., Jovanovic, T., Kubiak, T., Lieb, K., Lutz, B., Müller, M.B., Murray, R.J., Nievergelt, C.M., Reif, A., Roelofs, K., Rutten, B.P.F., Sander, D., Schick, A., Tüscher, O., Diest, I. van, Harmelen, A.L. van, Veer, I.M., Vermetten, E., Vinkers, C.H., Wager, T.D., Walter, H., Wessa, M., Wibral, M., Kleim, B., Kalisch, R., Baker, D.G., Basten, U., Boks, M.P.M., Bonanno, G.A., Brummelman, E., Chmitorz, A., Fernandez, G.S.E., Fiebach, C.J., Galatzer-Levy, I.R., Geuze, E., Groppa, S., Helmreich, I., Hendler, T., Hermans, E.J., Jovanovic, T., Kubiak, T., Lieb, K., Lutz, B., Müller, M.B., Murray, R.J., Nievergelt, C.M., Reif, A., Roelofs, K., Rutten, B.P.F., Sander, D., Schick, A., Tüscher, O., Diest, I. van, Harmelen, A.L. van, Veer, I.M., Vermetten, E., Vinkers, C.H., Wager, T.D., Walter, H., Wessa, M., Wibral, M., and Kleim, B.

Abstract

Item does not contain fulltext, Consistent failure over the past few decades to reduce the high prevalence of stress-related disorders has motivated a search for alternative research strategies. Resilience refers to the phenomenon of many people maintaining mental health despite exposure to psychological or physical adversity. Instead of aiming to understand the pathophysiology of stress-related disorders, resilience research focuses on protective mechanisms that shield people against the development of such disorders and tries to exploit its insights to improve treatment and, in particular, disease prevention. To fully harness the potential of resilience research, a critical appraisal of the current state of the art - in terms of basic concepts and key methods - is needed. We highlight challenges to resilience research and make concrete conceptual and methodological proposals to improve resilience research. Most importantly, we propose to focus research on the dynamic processes of successful adaptation to stressors in prospective longitudinal studies.

Published
2017

21. Resilience in mental health: linking psychological and neurobiological perspectives

Author

Rutten, B.P.F., Rutten, B.P.F., Hammels, C., Geschwind, N., Menne-Lothmann, C., Pishva, E., Schruers, K., van den Hove, D., Kenis, G., van Os, J., Wichers, M., Rutten, B.P.F., Rutten, B.P.F., Hammels, C., Geschwind, N., Menne-Lothmann, C., Pishva, E., Schruers, K., van den Hove, D., Kenis, G., van Os, J., and Wichers, M.

Abstract

Objective To review the literature on psychological and biological findings on resilience (i.e. the successful adaptation and swift recovery after experiencing life adversities) at the level of the individual, and to integrate findings from animal and human studies. Method Electronic and manual literature search of MEDLINE, EMBASE and PSYCHINFO, using a range of search terms around biological and psychological factors influencing resilience as observed in human and experimental animal studies, complemented by review articles and cross-references. Results The term resilience is used in the literature for different phenomena ranging from prevention of mental health disturbance to successful adaptation and swift recovery after experiencing life adversities, and may also include post-traumatic psychological growth. Secure attachment, experiencing positive emotions and having a purpose in life are three important psychological building blocks of resilience. Overlap between psychological and biological findings on resilience in the literature is most apparent for the topic of stress sensitivity, although recent results suggest a crucial role for reward experience in resilience. Conclusion Improving the understanding of the links between genetic endowment, environmental impact and gene-environment interactions with developmental psychology and biology is crucial for elucidating the neurobiological and psychological underpinnings of resilience.

Published
2013

23. Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

Author

Bardy, C., Hurk, M. van den, Kakaradov, B., Erwin, J.A., Jaeger, B.N., Hernandez, R.V., Eames, T., Paucar, A.A., Gorris, M.A., Marchand, C., Jappelli, R., Barron, J., Bryant, A.K., Kellogg, M., Lasken, R.S., Rutten, B.P.F., Steinbusch, H.W., Yeo, G.W., Gage, F.H., Bardy, C., Hurk, M. van den, Kakaradov, B., Erwin, J.A., Jaeger, B.N., Hernandez, R.V., Eames, T., Paucar, A.A., Gorris, M.A., Marchand, C., Jappelli, R., Barron, J., Bryant, A.K., Kellogg, M., Lasken, R.S., Rutten, B.P.F., Steinbusch, H.W., Yeo, G.W., and Gage, F.H.

Abstract

Item does not contain fulltext, Human neural progenitors derived from pluripotent stem cells develop into electrophysiologically active neurons at heterogeneous rates, which can confound disease-relevant discoveries in neurology and psychiatry. By combining patch clamping, morphological and transcriptome analysis on single-human neurons in vitro, we defined a continuum of poor to highly functional electrophysiological states of differentiated neurons. The strong correlations between action potentials, synaptic activity, dendritic complexity and gene expression highlight the importance of methods for isolating functionally comparable neurons for in vitro investigations of brain disorders. Although whole-cell electrophysiology is the gold standard for functional evaluation, it often lacks the scalability required for disease modeling studies. Here, we demonstrate a multimodal machine-learning strategy to identify new molecular features that predict the physiological states of single neurons, independently of the time spent in vitro. As further proof of concept, we selected one of the potential neurophysiological biomarkers identified in this study-GDAP1L1-to isolate highly functional live human neurons in vitro.

Published
2016

25. Stoornis in de lichaamsbeleving bij patiënten binnen de cosmetische chirurgie

Author

Hundscheid, T., van der Hulst, Rene, Rutten, B.P.F., Leue, Carsten, MUMC+: MA Plastische Chirurgie (3), Plastische Chirurgie (PLC), MUMC+: MA Plastische Chirurgie (9), Surgery, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), RS: MHeNs - R2 - Mental Health, and RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

Published
2014

27. DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

Author

Chouliaras, L., Kenis, G., Visser, P.J., Scheltens, P., Tsolaki, M., Jones, R.W., Kehoe, P.G., Graff, C., Girtler, N.G., Wallin, A.K., Olde Rikkert, M.G.M., Spiru, L., Elias-Sonnenschein, L.S., Ramakers, I.H., Pishva, E., Os, J. van, Steinbusch, H.W., Verhey, F.R.J., Hove, D.L. van den, Rutten, B.P.F., Chouliaras, L., Kenis, G., Visser, P.J., Scheltens, P., Tsolaki, M., Jones, R.W., Kehoe, P.G., Graff, C., Girtler, N.G., Wallin, A.K., Olde Rikkert, M.G.M., Spiru, L., Elias-Sonnenschein, L.S., Ramakers, I.H., Pishva, E., Os, J. van, Steinbusch, H.W., Verhey, F.R.J., Hove, D.L. van den, and Rutten, B.P.F.

Abstract

Item does not contain fulltext, Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.

Published
2015

28. Treatment of cognitive impairment in schizophrenia: potential value of phosphodiesterase inhibitors in prefrontal dysfunction

Author

van Duinen, M., van Duinen, M., Reneerkens, O.A.H., Lambrecht, L., Sambeth, A., Rutten, B.P.F., van Os, J., Blokland, A., Prickaerts, J., van Duinen, M., van Duinen, M., Reneerkens, O.A.H., Lambrecht, L., Sambeth, A., Rutten, B.P.F., van Os, J., Blokland, A., and Prickaerts, J.

Abstract

No pharmacological treatment is available to date that shows satisfactory effects on cognitive symptoms in patients diagnosed with schizophrenia. Phosphodiesterase inhibitors (PDE-Is) improve neurotransmitter signaling by interfering in intracellular second messenger cascades. By preventing the breakdown of cAMP and/or cGMP, central neurotransmitter activity is maintained. Different PDE families exist with distinct characteristics among which substrate specificity and regional distribution. Preclinical data is promising especially with regard to inhibition of PDE2, PDE4, PDE5 and PDE10. In addition, cognitive improvement has been reported in both elderly and/ or non-impaired young human subjects after PDE1 or PDE4 inhibition. Moreover, some of these studies show effects on cognitive domains relevant to schizophrenia, in particular memory. The current review incorporates an overview of the distinct molecular characteristics of the different PDE families and their relationship to the neurobiological mechanisms related to cognitive dysfunction in schizophrenia. So far, procognitive effects of only three types of PDE-Is have been assessed in patients diagnosed with schizophrenia inhibiting PDE3, PDE5 and PDE10. However, the limited data available do not allow to draw firm conclusions on the value of PDE-Is as cognitive enhancers in schizophrenia yet. The field is still in its infancy, but nevertheless different PDE-Is seem promising as candidate to optimise neural communication in the prefrontal cortex favouring cognitive functioning in patients diagnosed with schizophrenia, in particular dual inhibitors including PDE1-Is, PDE3-Is and PDE10A-Is.

Published
2015

29. Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress

Author

Peerbooms, O., Rutten, B.P.F., Collip, D., Lardinois, M., Lataster, T., Thewissen, V., Mafi Rad, S., Drukker, M., Kenis, G., van Os, Jim, Myin-Germeys, Inez, van Winkel, Ruud, Psychiatrie & Neuropsychologie, and RS: MHeNs School for Mental Health and Neuroscience

Subjects
epistasis, Adult, Male, Polymorphism, Genetic, Genotype, epigenesis, psychotic disorder, Middle Aged, Resilience, Psychological, Catechol O-Methyltransferase, stress, Gene Frequency, Psychotic Disorders, Case-Control Studies, Adaptation, Psychological, Humans, Female, environment, Methylenetetrahydrofolate Reductase (NADPH2), Stress, Psychological
Abstract

Objective: A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met x MTHFR interaction on resilience to stress in patients and controls remains to be examined. Method: A total of 98 patients with non-affective psychotic disorder and 118 controls were genotyped for MTHFR C677T, MTHFR A1298C, and COMTVal158Met. Daily life reactivity to stress, modelled as the effect of daily life stress on psychotic experiences, was measured using the experience sampling method (ESM). Results: The MTHFR C677T genotype moderated the interaction between COMT Val158Met genotype and stress in patients (P

Published
2011
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31. Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer's disease.

Author

Takahashi, H., Brasnjevic, I., Rutten, B.P.F., Kolk, N.M. van der, Perl, D.P., Bouras, C., Steinbusch, H.W., Schmitz, C., Hof, P.R., Dickstein, D.L., Takahashi, H., Brasnjevic, I., Rutten, B.P.F., Kolk, N.M. van der, Perl, D.P., Bouras, C., Steinbusch, H.W., Schmitz, C., Hof, P.R., and Dickstein, D.L.

Abstract

01 maart 2010, Item does not contain fulltext, Hippocampal atrophy and neuron loss are commonly found in Alzheimer's disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that express the calcium-binding proteins parvalbumin (PV) and calretinin (CR) has not yet been properly assessed. Using quantitative stereologic methods, we analyzed the regional pattern of age-related loss of PV- and CR-immunoreactive (ir) neurons in the hippocampus of mice that carry M233T/L235P knocked-in mutations in presenilin-1 (PS1) and overexpress a mutated human beta-amyloid precursor protein (APP), namely, the APP(SL)/PS1 KI mice, as well as in APP(SL) mice and PS1 KI mice. We found a loss of PV-ir neurons (40-50%) in the CA1-2, and a loss of CR-ir neurons (37-52%) in the dentate gyrus and hilus of APP(SL)/PS1 KI mice. Interestingly, comparable PV- and CR-ir neuron losses were observed in the dentate gyrus of postmortem brain specimens obtained from patients with AD. The loss of these interneurons in AD may have substantial functional repercussions on local inhibitory processes in the hippocampus.

Published
2010

35. The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings from the Multinational EU-GEI Study

Author

Andrea Tortelli, Peter B. Jones, Jim van Os, Caterina La Cascia, Bart P. F. Rutten, Eva Velthorst, Baptiste Pignon, Celso Arango, Sarah Tosato, Lieuwe de Haan, Julio Sanjuán, Marion Leboyer, James B. Kirkbride, Antonio Lasalvia, Diego Quattrone, Cristina Marta Del-Ben, Andrei Szöke, Grégoire Baudin, Charlotte Gayer-Anderson, Pierre-Michel Llorca, Paulo Rossi Menezes, Robin M. Murray, Julio Bobes, Hannah E Jongsma, Miguel Bernardo, Mohamed Lajnef, Jean-Paul Selten, Hugo Peyre, Jean-Romain Richard, Franck Schürhoff, Craig Morgan, Marta Di Forti, Ilaria Tarricone, Mauro Braca, Manuel Arrojo, Aziz Ferchiou, Pignon, B., Lajnef, M., Kirkbride, J.B., Peyre, H., Ferchiou, A., Richard, J.-R., Baudin, G., Tosato, S., Jongsma, H., De Haan, L., Tarricone, I., Bernardo, M., Velthorst, E., Braca, M., Arango, C., Arrojo, M., Bobes, J., Del-Ben, C.M., Di Forti, M., Gayer-Anderson, C., Jones, P.B., La Cascia, C., Lasalvia, A., Menezes, P.R., Quattrone, D., Sanjuán, J., Selten, J.-P., Tortelli, A., Llorca, P.-M., Van Os, J., Rutten, B.P.F., Murray, R.M., Morgan, C., Leboyer, M., Szöke, A., Schürhoff, F., Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Adult Psychiatry, APH - Mental Health, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Pignon B., Lajnef M., Kirkbride J.B., Peyre H., Ferchiou A., Richard J.-R., Baudin G., Tosato S., Jongsma H., De Haan L., Tarricone I., Bernardo M., Velthorst E., Braca M., Arango C., Arrojo M., Bobes J., Del-Ben C.M., Di Forti M., Gayer-Anderson C., Jones P.B., La Cascia C., Lasalvia A., Menezes P.R., Quattrone D., Sanjuan J., Selten J.-P., Tortelli A., Llorca P.-M., Van Os J., Rutten B.P.F., Murray R.M., Morgan C., Leboyer M., Szoke A., Schurhoff F., Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), and RS: MHeNs - R3 - Neuroscience

Subjects
Male, stressful life events, Schizotypy, positive subclinical symptom, Ethnic group, Social Environment, subclinical psychosis, positive subclinical symptoms, 0302 clinical medicine, Adverse Childhood Experiences, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, SINTOMAS PSÍQUICOS, subclinical psychosi, 10. No inequality, COMMUNITY ASSESSMENT, Subclinical infection, GENERAL-POPULATION, psychotic symptom, Depression, Confounding, Social Discrimination, depressive subclinical symptom, stressful life event, ETHNIC-GROUPS, 3. Good health, Psychiatry and Mental health, NEIGHBORHOOD CHARACTERISTICS, ADULT PSYCHIATRIC-DISORDERS, psychotic symptoms, Adverse Childhood Experience, Female, psychosocial stress, Psychology, Psychosocial, Human, Clinical psychology, negative subclinical symptom, psychosocial stre, Adult, Psychosis, Sibling, LIFE EVENTS, schizotypy, Psychotic Disorder, 03 medical and health sciences, Community Assessment of Psychic Experiences (CAPE), THREATENING EXPERIENCES, medicine, Humans, European Union, Settore MED/25 - Psichiatria, childhood trauma, Siblings, Stressor, medicine.disease, PERCEIVED DISCRIMINATION, negative subclinical symptoms, 030227 psychiatry, PSYCHOMETRIC PROPERTIES, Psychotic Disorders, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, dis crimination, social capital, depressive subclinical symptoms, Stress, Psychological, 030217 neurology & neurosurgery, Regular Articles, discrimination
Abstract

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors that may be the consequence of the disorder rather than preexisting. The study of subclinical psychosis could help to address some of these issues. In this study, we investigated whether there was (i) an association between dimensions of subclinical psychosis and several psychosocial stressors including: childhood trauma, self-reported discrimination experiences, low social capital, and stressful life experiences, and (ii) any evidence of environment-environment (ExE) interactions between these factors. Data were drawn from the EUGEI study, in which healthy controls (N = 1497) and siblings of subjects with a psychotic disorder (N = 265) were included in six countries. The association between psychosocial stressors and subclinical psychosis dimensions (positive, negative and depressive dimension as measured by the Community Assessment of Psychic Experiences (CAPE) scale) and possible ExE interactions were assessed using linear regression models. After adjusting for sex, age, ethnicity, country, and control/sibling status, childhood trauma (beta for positive dimension: 0.13, negative: 0.49, depressive: 0.26) and stressful life events (positive: 0.08, negative: 0.16, depressive: 0.17) were associated with the three dimensions. Lower social capital was associated with the negative and depression dimensions (negative: 0.26, depressive: 0.13), and self-reported discrimination experiences with the positive dimension (0.06). Our findings are in favor of independent, cumulative and non-specific influences of social adversities in subclinical psychosis in non-clinical populations, without arguments for E * E interactions. © The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Published
2021
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36. Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study

Author

B. Pignon, H. Peyre, A. Ayrolles, J. B. Kirkbride, S. Jamain, A. Ferchiou, J. R. Richard, G. Baudin, S. Tosato, H. Jongsma, L. de Haan, I. Tarricone, M. Bernardo, E. Velthorst, M. Braca, C. Arango, M. Arrojo, J. Bobes, C. M. Del-Ben, M. Di Forti, C. Gayer-Anderson, P. B. Jones, C. La Cascia, A. Lasalvia, P. R. Menezes, D. Quattrone, J. Sanjuán, J. P. Selten, A. Tortelli, P. M. Llorca, J. van Os, B. P. F. Rutten, R. M. Murray, C. Morgan, M. Leboyer, A. Szöke, F. Schürhoff, Pignon B., Peyre H., Ayrolles A., Kirkbride J.B., Jamain S., Ferchiou A., Richard J.R., Baudin G., Tosato S., Jongsma H., de Haan L., Tarricone I., Bernardo M., Velthorst E., Braca M., Arango C., Arrojo M., Bobes J., Del-Ben C.M., Di Forti M., Gayer-Anderson C., Jones P.B., La Cascia C., Lasalvia A., Menezes P.R., Quattrone D., Sanjuan J., Selten J.P., Tortelli A., Llorca P.M., van Os J., Rutten B.P.F., Murray R.M., Morgan C., Leboyer M., Szoke A., Schurhoff F., Pignon, B [0000-0003-0526-3136], Ayrolles, A [0000-0002-3202-0781], Kirkbride, JB [0000-0003-3401-0824], Tosato, S [0000-0002-9665-7538], Lasalvia, A [0000-0001-9963-6081], Morgan, C [0000-0002-1386-2369], Apollo - University of Cambridge Repository, Pignon, B, Peyre, H, Ayrolles, A, Kirkbride, J B, Jamain, S, Ferchiou, A, Richard, J R, Baudin, G, Tosato, S, Jongsma, H, de Haan, L, Tarricone, I, Bernardo, M, Velthorst, E, Braca, M, Arango, C, Arrojo, M, Bobes, J, Del-Ben, C M, Di Forti, M, Gayer-Anderson, C, Jones, P B, La Cascia, C, Lasalvia, A, Menezes, P R, Quattrone, D, Sanjuán, J, Selten, J P, Tortelli, A, Llorca, P M, van Os, J, Rutten, B P F, Murray, R M, Morgan, C, Leboyer, M, Szöke, A, Schürhoff, F, Adult Psychiatry, APH - Mental Health, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: Hersen en Zenuw Centrum (3), MUMC+: VPK Flexteam IC (9), MUMC+: MA Psychiatrie (3), and RS: MHeNs - R3 - Neuroscience

Subjects
Schizophrenia/genetics, Environmental effects on human beings, Risk factors in diseases, Epidemiology, Psicosi, psychosi, Pathological psychology, Genes × environment interaction, Risk Factors, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, psychosocial stressors, Humans, psychosis, Psychotic Disorders/genetics, Settore MED/25 - Psichiatria, Influència del medi ambient en l'home, Genètica de la conducta, Factors de risc en les malalties, Genes × environment interactions, Public Health, Environmental and Occupational Health, Psychoses, polygenic risk score for schizophrenia, Psicopatologia, Psychiatry and Mental health, Psychotic Disorders, Behavior genetics, Schizophrenia, Esquizofrènia, Gene-Environment Interaction
Abstract

the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union Seventh Framework Program under grant agreements FP7-4-HEALTH-2009-2.2.1-2-241909 (Project EU-GEI) and FP7-HEALTH-2013-2.2.1-2-603196 (Project PSYSCAN); and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No 115916, Project PRISM, and grant agreement No 777394, Project AIMS-2-TRIALS) (...), Pignon B, Peyre H, Ayrolles A, Kirkbride JB, Jamain S, Ferchiou A, Richard JR, Baudin G, Tosato S, Jongsma H, de Haan L, Tarricone I, Bernardo M, Velthorst E, Braca M, Arango C, Arrojo M, Bobes J, Del-Ben CM, Di Forti M, Gayer-Anderson C, Jones PB, La Cascia C, Lasalvia A, Menezes PR, Quattrone D, Sanjuán J, Selten JP, Tortelli A, Llorca PM, van Os J, Rutten BPF, Murray RM, Morgan C, Leboyer M, Szöke A, Schürhoff F

Published
2022
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37. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author

Velthorst E., Mollon J., Murray R. M., de Haan L., Germeys I. M., Glahn D. C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P. A., Garcia-Portilla M. P., Santos J. L., Jimenez-Lopez E., Sanjuan J., Aguilar E. J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M. C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B. C., Soygur H., Cankurtaran E. S., Kaymak S. U., Maric N. P., Mihaljevic M. M., Petrovic S. A., Mirjanic T., Del-Ben C. M., Ferraro L., Gayer-Anderson C., Jones P. B., Jongsma H. E., Kirkbride J. B., La Cascia C., Lasalvia A., Tosato S., Llorca P. -M., Menezes P. R., Morgan C., Quattrone D., Menchetti M., Selten J. -P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M. J., van der Gaag M., Riecher-Rossler A., Bressan R. A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M. -O., Ruhrmann S., Sachs G., Rutten B. P. F., van Os J., Alizadeh B. Z., van Amelsvoort T., Bartels-Velthuis A. A., Bruggeman R., van Beveren N. J., Luykx J. J., Cahn W., Simons C. J. P., Kahn R. S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T. C., van Dam D. S., Burger N., Amminger G. P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T. R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L. B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., Velthorst E., Mollon J., Murray R.M., de Haan L., Germeys I.M., Glahn D.C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P.A., Garcia-Portilla M.P., Santos J.L., Jimenez-Lopez E., Sanjuan J., Aguilar E.J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M.C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B.C., Soygur H., Cankurtaran E.S., Kaymak S.U., Maric N.P., Mihaljevic M.M., Petrovic S.A., Mirjanic T., Del-Ben C.M., Ferraro L., Gayer-Anderson C., Jones P.B., Jongsma H.E., Kirkbride J.B., La Cascia C., Lasalvia A., Tosato S., Llorca P.-M., Menezes P.R., Morgan C., Quattrone D., Menchetti M., Selten J.-P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M.J., van der Gaag M., Riecher-Rossler A., Bressan R.A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M.-O., Ruhrmann S., Sachs G., Rutten B.P.F., van Os J., Alizadeh B.Z., van Amelsvoort T., Bartels-Velthuis A.A., Bruggeman R., van Beveren N.J., Luykx J.J., Cahn W., Simons C.J.P., Kahn R.S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T.C., van Dam D.S., Burger N., Amminger G.P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T.R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L.B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Neurosciences, Psychiatry, Clinical Developmental Psychology, World Health Organization (WHO) Collaborating Center, Life Course Epidemiology (LCE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
0301 basic medicine, validity, medicine.medical_treatment, CHILDHOOD, Neuropsychological Tests, FAMÍLIA, episode, Cognition, 0302 clinical medicine, DEFICITS, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Medicine, Cognitive impairment, Psychiatry, Symptom severity, Cannabis use, IMPAIRMENT, ABILITY, Psychiatry and Mental health, Schizophrenia, RELIABILITY, Neuropsychological Test, Life Sciences & Biomedicine, Human, Clinical psychology, Adult, Biochemistry & Molecular Biology, impairment, schizophrenia-patients, ability, GENETIC RISK, Psychotic Disorder, SCHIZOPHRENIA-PATIENTS, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Settore M-PSI/08 - Psicologia Clinica, Humans, In patient, Cognitive skill, VALIDITY, Antipsychotic, Molecular Biology, Settore MED/25 - Psichiatria, Aged, Cross-Sectional Studie, DECLINE, Science & Technology, reliability, business.industry, Working memory, Siblings, Neurosciences, Diagnostic markers, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, deficits, Psychotic Disorders, PSYCHOSIS, COGNITION, MULTICENTRIC STUDY, Neurosciences & Neurology, business, EPISODE, 030217 neurology & neurosurgery
Abstract

The European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (EUGEI); The Spanish sample was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024) (...), Velthorst, E., Mollon, J., Murray, R.M., de Haan, L., Germeys, I.M., Glahn, D.C., Arango, C., van der Ven, E., Di Forti, M., Bernardo, M., Guloksuz, S., Delespaul, P., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., García-Portilla, M.P., Santos, J.L., Jiménez-López, E., Sanjuan, J., Aguilar, E.J., Arrojo, M., Carracedo, A., López, G., González-Peñas, J., Parellada, M., Atbaşoğlu, C., Saka, M.C., Üçok, A., Alptekin, K., Akdede, B., Binbay, T., Altınyazar, V., Ulaş, H., Yalınçetin, B., Gümüş-Akay, G., Beyaz, B.C., Soygür, H., Cankurtaran, E.Ş., Kaymak, S.U., Maric, N.P., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Del-Ben, C.M., Ferraro, L., Gayer-Anderson, C., Jones, P.B., Jongsma, H.E., Kirkbride, J.B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P.-M., Menezes, P.R., Morgan, C., Quattrone, D., Menchetti, M., Selten, J.-P., Szöke, A., Tarricone, I., Tortelli, A., McGuire, P., Valmaggia, L., Kempton, M.J., van der Gaag, M., Riecher-Rössler, A., Bressan, R.A., Barrantes-Vidal, N., Nelson, B., McGorry, P., Pantelis, C., Krebs, M.-O., Ruhrmann, S., Sachs, G., Rutten, B.P.F., van Os, J., Alizadeh, B.Z., van Amelsvoort, T., Bartels-Velthuis, A.A., Bruggeman, R., van Beveren, N.J., Luykx, J.J., Cahn, W., Simons, C.J.P., Kahn, R.S., Schirmbeck, F., van Winkel, R., Calem, M., Tognin, S., Modinos, G., Pisani, S., Kraan, T.C., van Dam, D.S., Burger, N., Amminger, G.P., Politis, A., Goodall, J., Borgwardt, S., Studerus, E., Gadelha, A., Brietzke, E., Asevedo, G., Asevedo, E., Zugman, A., Domínguez-Martínez, T., Monsonet, M., Cristóbal-Narváez, P., Racioppi, A., Kwapil, T.R., Kazes, M., Daban, C., Bourgin, J., Gay, O., Mam-Lam-Fook, C., Nordholm, D., Rander, L., Krakauer, K., Glenthøj, L.B., Glenthøj, B., Gebhard, D., Arnhold, J., Klosterkötter, J., Lasser, I., Winklbaur, B., Reichenberg, A., EU-GEI High Risk Study

Published
2021
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38. Jumping to conclusions, general intelligence, and psychosis liability: Findings from the multi-centre EU-GEI case-control study

Author

Fabio Seminerio, Andrei Szöke, Antonio Lasalvia, Diego Quattrone, Domenico Berardi, Jean-Paul Selten, Ilaria Tarricone, Peter B. Jones, Graham K. Murray, Miguel Bernardo, José Luis Santos, Pierre-Michel Llorca, Alexander Richards, Caterina La Cascia, Celso Arango, Manuel Arrojo, Victoria Rodriguez, Lieuwe de Haan, Craig Morgan, Crocettarachele Sartorio, Michael Conlon O'Donovan, Andrea Tortelli, Laura Ferraro, Julio Sanjuán, Robin M. Murray, Hannah E. Jongsma, Marta Di Forti, Cristina Marta Del-Ben, Eva Velthorst, Jim van Os, Daniele La Barbera, Bart P. F. Rutten, Julio Bobes, Sarah Tosato, Pak C. Sham, James B. Kirkbride, Paulo Rossi Menezes, Charlotte Gayer-Anderson, Giada Tripoli, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Tripoli G., Quattrone D., Ferraro L., Gayer-Anderson C., Rodriguez V., La Cascia C., La Barbera D., Sartorio C., Seminerio F., Tarricone I., Berardi D., Szoke A., Arango C., Tortelli A., Llorca P.-M., De Haan L., Velthorst E., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Del-Ben C.M., Menezes P.R., Selten J.-P., Jones P.B., Jongsma H.E., Kirkbride J.B., Lasalvia A., Tosato S., Richards A., O'donovan M., Rutten B.P.F., Os J.V., Morgan C., Sham P.C., Murray R.M., Murray G.K., Di Forti M., Adult Psychiatry, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Tripoli, Giada, Quattrone, Diego, Ferraro, Laura, Gayer-Anderson, Charlotte, Rodriguez, Victoria, La Cascia, Caterina, La Barbera, Daniele, Sartorio, Crocettarachele, Seminerio, Fabio, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, Llorca, Pierre-Michel, de Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Lui, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Jongsma, Hannah E, Kirkbride, James B, Lasalvia, Antonio, Tosato, Sarah, Richards, Alex, O'Donovan, Michael, Rutten, Bart Pf, Os, Jim van, Morgan, Craig, Sham, Pak C, Murray, Robin M, Murray, Graham K, Di Forti, Marta, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), and MUMC+: Hersen en Zenuw Centrum (3)

Subjects
Male, MISCOMPREHENSION, Intelligence, DELÍRIO, 0302 clinical medicine, Cognition, SCHIZOPHRENIA, psychotic-like experience, jumping to conclusions, Applied Psychology, Problem Solving, RISK, education.field_of_study, Middle Aged, 16. Peace & justice, Cognitive bias, 3. Good health, First episode psychosis, IQ, polygenic risk score, psychotic-like experiences, symptom dimensions, Psychiatry and Mental health, BIAS, Schizophrenia, RELIABILITY, Female, Original Article, jumping to conclusion, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Clinical psychology, Adult, Psychosis, Adolescent, DISORDERS, Population, REEXAMINATION, Delusions, 03 medical and health sciences, Young Adult, PEOPLE, medicine, Humans, Cognitive Dysfunction, education, DELUSIONAL IDEATION, Cognitive deficit, business.industry, Case-control study, medicine.disease, First episode psychosi, 030227 psychiatry, Psychotic Disorders, Case-Control Studies, Jumping to conclusions, business, 030217 neurology & neurosurgery
Abstract

This study was funded by the Medical Research Council, the European Community’s Seventh Framework Program grant [agreement HEALTH-F2-2009-241909 (Project EU-GEI)], São Paulo Research Foundation (grant 2012/0417-0), the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust and King’s College London, the NIHR BRC at University College London and the Wellcome Trust (grant 101272/Z/12/Z)., Tripoli, G., Quattrone, D., Ferraro, L., Gayer-Anderson, C., Rodriguez, V., La Cascia, C., La Barbera, D., Sartorio, C., Seminerio, F., Tarricone, I., Berardi, D., Szöke, A., Arango, C., Tortelli, A., Llorca, P.-M., De Haan, L., Velthorst, E., Bobes, J., Bernardo, M., Sanjuán, J., Santos, J.L., Arrojo, M., Del-Ben, C.M., Menezes, P.R., Selten, J.-P., Jones, P.B., Jongsma, H.E., Kirkbride, J.B., Lasalvia, A., Tosato, S., Richards, A., O'donovan, M., Rutten, B.P.F., Os, J.V., Morgan, C., Sham, P.C., Murray, R.M., Murray, G.K., Di Forti, M.

Published
2021
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39. Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis

Author

Robin M. Murray, Luis Alameda, Andrea Tortelli, Laura Ferraro, Cristina Marta Del-Ben, Eva Velthorst, Peter B. Jones, Monica Aas, James B. Kirkbride, Pierre-Michel Llorca, Evangelos Vassos, Hannah E. Jongsma, Paola Dazzan, Jean-Paul Selten, Miguel Bernardo, Victoria Rodriguez, Lieuwe de Haan, Marta Di Forti, Jose Luis Santos, Roberto Muratori, Caterina La Cascia, Manuel Arrojo, Pak C. Sham, Jim van Os, Bart P. F. Rutten, Daniele La Barbera, Celso Arango, Ilaria Tarricone, Domenico Berardi, Sarah Tosato, Craig Morgan, Julio Bobes, Paulo Rossi Menezes, Antonella Trotta, Julio Sanjuán, Andrei Szöke, Antonio Lasalvia, Diego Quattrone, Charlotte Gayer-Anderson, Giada Tripoli, Aas M., Alameda L., Di Forti M., Quattrone D., Dazzan P., Trotta A., Ferraro L., Rodriguez V., Vassos E., Sham P., Tripoli G., La Cascia C., La Barbera D., Tarricone I., Muratori R., Berardi D., Lasalvia A., Tosato S., Szoke A., Llorca P.-M., Arango C., Tortelli A., De Haan L., Velthorst E., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Del-Ben C.M., Menezes P.R., Selten J.-P., Jones P.B., Jongsma H.E., Kirkbride J.B., Rutten B.P.F., Van Os J., Gayer-Anderson C., Murray R.M., Morgan C., Cascia C.L., Barbera D.L., RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Psychiatrie (3), RS: MHeNs - R2 - Mental Health, MUMC+: Hersen en Zenuw Centrum (3), Adult Psychiatry, APH - Mental Health, ANS - Complex Trait Genetics, and ANS - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
SCHIZOPHRENIA SPECTRUM, medicine.medical_specialty, GENES, polygenic risk, first-episode psychosi, ILLNESS, interaction contrast ratio, Childhood trauma, DOPAMINE, First episode psychosis, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, MALTREATMENT, Medicine, first-episode psychosis, ABUSE, Psychiatry, Settore MED/25 - Psichiatria, Applied Psychology, TRAUMA, ENVIRONMENT, business.industry, medicine.disease, schizophrenia, Psychiatry and Mental health, Schizophrenia, RELIABILITY, Polygenic risk score, synergistic effects, business
Abstract

The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme., Aas, M; Alameda, L; Di Forti, M; Quattrone, D; Dazzan, P; Trotta, A; Ferraro, L; Rodriguez, V; Vassos, E; Sham, P; Tripoli, G; La Cascia, C; La Barbera, D; Tarricone, I; Muratori, R; Berardi, D; Lasalvia, A; Tosato, S; Szoke, A; Llorca, PM; Arango, C; Tortelli, A; de Haan, L; Velthorst, E; Bobes, J; Bernardo, M; Sanjuan, J; Santos, JL; Arrojo, M; Del-Ben, CM; Menezes, PR; Selten, JP; Jones, PB; Jongsma, HE; Kirkbride, JB; Rutten, BPF; van Os, J; Gayer-Anderson, C; Murray, RM; Morgan, C

Published
2021

40. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Author

Quattrone, Diego, Reininghaus, Ulrich, Richards, Alex L., Tripoli, Giada, Ferraro, Laura, Quattrone, Andrea, Marino, Paolo, Rodriguez, Victoria, Spinazzola, Edoardo, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Jones, Peter B., La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Bonora, Elena, Tosato, Sarah, Lasalvia, Antonio, Szöke, Andrei, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Del Ben, Cristina Marta, Menezes, Paulo Rossi, Llorca, Pierre-Michel, Santos, Jose Luis, Sanjuán, Julio, Arrojo, Manuel, Tortelli, Andrea, Velthorst, Eva, Berendsen, Steven, de Haan, Lieuwe, Rutten, Bart P. F., Lynskey, Michael T., Freeman, Tom P., Kirkbride, James B., Sham, Pak C., O'Donovan, Michael C., Cardno, Alastair G., Vassos, Evangelos, van Os, Jim, Morgan, Craig, Murray, Robin M., Lewis, Cathryn M., Di Forti, Marta, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Fraguas, David, Castro, Marta Rapado, Andreu-Bernabeu, Álvaro, López, Gonzalo, Matteis, Mario, González, Emiliano, Durán-Cutilla, Manuel, Díaz-Caneja, Covadonga M., Cuadrado, Pedro, Rodríguez Solano, José Juan, Carracedo, Angel, Costas, Javier, Sánchez, Emilio, Amoretti, Silvia, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, van Dam, Daniella, Termorshuizen, Fabian, van der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schu?rhoff, Franck, Jamain, Stéphane, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Bonetto, Chiara, Cristofalo, Doriana, Berardi, Domenico, Seri, Marco, D?Andrea, Giuseppe, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Quattrone D., Reininghaus U., Richards A.L., Tripoli G., Ferraro L., Quattrone A., Marino P., Rodriguez V., Spinazzola E., Gayer-Anderson C., Jongsma H.E., Jones P.B., La Cascia C., La Barbera D., Tarricone I., Bonora E., Tosato S., Lasalvia A., Szoke A., Arango C., Bernardo M., Bobes J., Del Ben C.M., Menezes P.R., Llorca P.-M., Santos J.L., Sanjuan J., Arrojo M., Tortelli A., Velthorst E., Berendsen S., de Haan L., Rutten B.P.F., Lynskey M.T., Freeman T.P., Kirkbride J.B., Sham P.C., O'Donovan M.C., Cardno A.G., Vassos E., van Os J., Morgan C., Murray R.M., Lewis C.M., Di Forti M., Hubbard K., Beards S., Stilo S.A., Parellada M., Fraguas D., Castro M.R., Andreu-Bernabeu A., Lopez G., Matteis M., Gonzalez E., Duran-Cutilla M., Diaz-Caneja C.M., Cuadrado P., Rodriguez Solano J.J., Carracedo A., Costas J., Sanchez E., Amoretti S., Lorente-Rovira E., Garcia-Portilla P., Jimenez-Lopez E., Franke N., van Dam D., Termorshuizen F., van der Ven E., Messchaart E., Leboyer M., Schurhoff F., Jamain S., Baudin G., Ferchiou A., Pignon B., Richard J.-R., Charpeaud T., Tronche A.-M., Frijda F., Marrazzo G., Sideli L., Sartorio C., Seminerio F., Loureiro C.M., Shuhama R., Ruggeri M., Bonetto C., Cristofalo D., Berardi D., Seri M., D'Andrea G., Quattrone, Diego [0000-0002-6051-8309], Richards, Alex L [0000-0003-3218-7247], Marino, Paolo [0000-0003-3571-1753], Rodriguez, Victoria [0000-0003-0383-0846], Jones, Peter B [0000-0002-0387-880X], Tosato, Sarah [0000-0002-9665-7538], Bernardo, Miquel [0000-0001-8748-6717], Bobes, Julio [0000-0003-2187-4033], Del Ben, Cristina Marta [0000-0003-0145-9975], Menezes, Paulo Rossi [0000-0001-6330-3314], Llorca, Pierre-Michel [0000-0001-7438-8990], Rutten, Bart PF [0000-0002-9834-6346], Kirkbride, James B [0000-0003-3401-0824], O'Donovan, Michael C [0000-0001-7073-2379], Vassos, Evangelos [0000-0001-6363-0438], Murray, Robin M [0000-0003-0829-0519], Lewis, Cathryn M [0000-0002-8249-8476], Apollo - University of Cambridge Repository, Rutten, Bart P F [0000-0002-9834-6346], Adult Psychiatry, APH - Mental Health, ANS - Complex Trait Genetics, and ANS - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
medicine.medical_specialty, Psychosis, Population, Neurosciences. Biological psychiatry. Neuropsychiatry, PHENOTYPES, ILLNESS, Psychotic Disorder, Predictive markers, Article, Cellular and Molecular Neuroscience, DEFICIT SYNDROME, Risk Factors, First episode psychosis, medicine, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Humans, Cannabi, Clinical genetics, Genetic risk, VALIDITY, education, Settore MED/25 - Psichiatria, SCHEDULE, Biological Psychiatry, METAANALYSIS, Cannabis, UTILITY, education.field_of_study, Risk Factor, ESQUIZOFRENIA, ASSOCIATION, Cannabis use, medicine.disease, BIFACTOR MODEL, Psychiatry and Mental health, Psychotic Disorders, INTERRATER RELIABILITY, Schizophrenia, Linear Models, Linear Model, Medical genetics, Polygenic risk score, Psychology, Human, RC321-571, Clinical psychology
Abstract

The work was supported by Guarantors of Brain post-doctoral clinical fellowship to DQ; Clinician Scientist Medical Research Council fellowship (project reference MR/M008436/1) to MDF; Heisenberg professorship from the German Research Founda- tion (grant no. 389624707) to UR; the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). The Brazilian study was funded by the São Paulo Research Foundation under grant number 2012/0417-0., Quattrone D., Reininghaus U., Richards A.L., Tripoli G., Ferraro L., Quattrone A., Marino P., Rodriguez V., Spinazzola E., Gayer-Anderson C., Jongsma H.E., Jones P.B., La Cascia C., La Barbera D., Tarricone I., Bonora E., Tosato S., Lasalvia A., Szöke A., Arango C., Bernardo M., Bobes J., Del Ben C.M., Menezes P.R., Llorca P.-M., Santos J.L., Sanjuán J., Arrojo M., Tortelli A., Velthorst E., Berendsen S., de Haan L., Rutten B.P.F., Lynskey M.T., Freeman T.P., Kirkbride J.B., Sham P.C., O’Donovan M.C., Cardno A.G., Vassos E., van Os J., Morgan C., Murray R.M., Lewis C.M., Di Forti M., Hubbard K., Beards S., Stilo S.A., Parellada M., Fraguas D., Castro M.R., Andreu-Bernabeu Á., López G., Matteis M., González E., Durán-Cutilla M., Díaz-Caneja C.M., Cuadrado P., Rodríguez Solano J.J., Carracedo A., Costas J., Sánchez E., Amoretti S., Lorente-Rovira E., Garcia-Portilla P., Jiménez-López E., Franke N., van Dam D., Termorshuizen F., van der Ven E., Messchaart E., Leboyer M., Schürhoff F., Jamain S., Baudin G., Ferchiou A., Pignon B., Richard J.-R., Charpeaud T., Tronche A.-M., Frijda F., Marrazzo G., Sideli L., Sartorio C., Seminerio F., Loureiro C.M., Shuhama R., Ruggeri M., Bonetto C., Cristofalo D., Berardi D., Seri M., D’Andrea G.

Published
2021

41. Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: The EU-GEI case-control study

Author

Quattrone, D, Ferraro, L, Tripoli, G, La Cascia, C, Quigley, H, Quattrone, A, Jongsma, HE, Del Peschio, S, Gatto, G, EU-GEI group, Gayer-Anderson, C, Jones, PB, Kirkbride, JB, La Barbera, D, Tarricone, I, Berardi, D, Tosato, S, Lasalvia, A, Szöke, A, Arango, C, Bernardo, M, Bobes, J, Del Ben, CM, Menezes, PR, Llorca, P-M, Santos, JL, Sanjuán, J, Tortelli, A, Velthorst, E, de Haan, L, Rutten, BPF, Lynskey, MT, Freeman, TP, Sham, PC, Cardno, AG, Vassos, E, van Os, J, Morgan, C, Reininghaus, U, Lewis, CM, Murray, RM, Di Forti, M, Adult Psychiatry, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Quattrone, Diego [0000-0002-6051-8309], Apollo - University of Cambridge Repository, Quattrone D., Ferraro L., Tripoli G., La Cascia C., Quigley H., Quattrone A., Jongsma H.E., Del Peschio S., Gatto G., EU-GEI group, Gayer-Anderson C., Jones P.B., Kirkbride J.B., La Barbera D., Tarricone I., Berardi D., Tosato S., Lasalvia A., Szoke A., Arango C., Bernardo M., Bobes J., Del Ben C.M., Menezes P.R., Llorca P.-M., Santos J.L., Sanjuan J., Tortelli A., Velthorst E., De Haan L., Rutten B.P.F., Lynskey M.T., Freeman T.P., Sham P.C., Cardno A.G., Vassos E., Van Os J., Morgan C., Reininghaus U., Lewis C.M., Murray R.M., Di Forti M., RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Psychiatrie (3), RS: MHeNs - R2 - Mental Health, and MUMC+: Hersen en Zenuw Centrum (3)

Subjects
Marijuana Abuse, IMPACT, Poison control, Cannabis use, cannabis-associated psychosis, 0302 clinical medicine, SCHIZOPHRENIA, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, health care economics and organizations, Applied Psychology, RISK, OUTCOMES, biology, Human factors and ergonomics, psychopathology, first episode psychosis, psychotic experiences, symptom dimensions, 3. Good health, Psychiatry and Mental health, Schizophrenia, HEALTH, Psychopathology, Psychosis, medicine.medical_specialty, DISORDERS, education, 03 medical and health sciences, Injury prevention, medicine, Humans, Psychiatry, ABUSE, Settore MED/25 - Psichiatria, SUBSTANCE USE, METAANALYSIS, Cannabis, business.industry, Case-control study, Original Articles, medicine.disease, biology.organism_classification, 030227 psychiatry, psychotic experience, Psychotic Disorders, first episode psychosi, Case-Control Studies, ONSET, Gene-Environment Interaction, business, cannabis-associated psychosi, 030217 neurology & neurosurgery
Abstract

The work was supported by: Clinician Scientist Medical Research Council fellowship (project reference MR/M008436/1) to MDF; the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital NHS Foundation Trust to DQ; DFG Heisenberg professorship (no. 389624707) to UR. National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The EU-GEI Project is funded by the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). The Brazilian study was funded by the São Paulo Research Foundation under grant number 2012/0417-0., Quattrone, D., Ferraro, L., Tripoli, G., La Cascia, C., Quigley, H., Quattrone, A., Jongsma, H.E., Del Peschio, S., Gatto, G., Gayer-Anderson, C., Jones, P.B., Kirkbride, J.B., La Barbera, D., Tarricone, I., Berardi, D., Tosato, S., Lasalvia, A., Szöke, A., Arango, C., Bernardo, M., Bobes, J., Del Ben, C.M., Menezes, P.R., Llorca, P.-M., Santos, J.L., Sanjuán, J., Tortelli, A., Velthorst, E., De Haan, L., Rutten, B.P.F., Lynskey, M.T., Freeman, T.P., Sham, P.C., Cardno, A.G., Vassos, E., Van Os, J., Morgan, C., Reininghaus, U., Lewis, C.M., Murray, R.M., Di Forti, M.

Published
2020
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42. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project

Author

Steven Berendsen, Pim Kapitein, Frederike Schirmbeck, Mirjam J. van Tricht, Philip McGuire, Craig Morgan, Charlotte Gayer-Anderson, Matthew J. Kempton, Lucia Valmaggia, Diego Quattrone, Marta di Forti, Mark van der Gaag, James B. Kirkbride, Hannah E. Jongsma, Peter B. Jones, Maria Parellada, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Sanjuán, José Luis Santos, Andrei Szöke, Andrea Tortelli, Pierre-Michel Llorca, Ilaria Tarricone, Giada Tripoli, Laura Ferraro, Caterina La Cascia, Antonio Lasalvia, Sarah Tosato, Paulo Rossi Menezes, Cristina Marta Del-Ben, Barnaby Nelson, Anita Riecher-Rössler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P.F. Rutten, Jim van Os, Eva Velthorst, Lieuwe de Haan, Maria Calem, Stefania Tognin, Gemma Modinos, Sara Pisani, Tamar C. Kraan, Daniella S. van Dam, Nadine Burger, Patrick McGorry, G. Paul Amminger, Athena Politis, Joanne Goodall, Stefan Borgwardt, Erich Studerus, Ary Gadelha, Elisa Brietzke, Graccielle Asevedo, Elson Asevedo, Andre Zugman, Tecelli Domínguez-Martínez, Manel Monsonet, Lidia Hinojosa, Paula Cristóbal-Narváez, Anna Racioppi, Thomas R. Kwapil, Mathilde Kazes, Claire Daban, Julie Bourgin, Olivier Gay, Célia Mam-Lam-Fook, Dorte Nordholm, Lasse Randers, Kristine Krakauer, Louise Birkedal Glenthøj, Birte Glenthøj, Dominika Gebhard, Julia Arnhold, Joachim Klosterkötter, Iris Lasser, Bernadette Winklbaur, Philippe A. Delespaul, Graduate School, Adult Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Berendsen S., Kapitein P., Schirmbeck F., van Tricht M.J., McGuire P., Morgan C., Gayer-Anderson C., Kempton M.J., Valmaggia L., Quattrone D., di Forti M., van der Gaag M., Kirkbride J.B., Jongsma H.E., Jones P.B., Parellada M., Arango C., Arrojo M., Bernardo M., Sanjuan J., Santos J.L., Szoke A., Tortelli A., Llorca P.-M., Tarricone I., Tripoli G., Ferraro L., La Cascia C., Lasalvia A., Tosato S., Menezes P.R., Del-Ben C.M., Nelson B., Riecher-Rossler A., Bressan R., Barrantes-Vidal N., Krebs M.-O., Nordentoft M., Ruhrmann S., Sachs G., Rutten B.P.F., van Os J., Velthorst E., de Haan L., Calem M., Tognin S., Modinos G., Pisani S., Kraan T.C., van Dam D.S., Burger N., McGorry P., Amminger G.P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Hinojosa L., Cristobal-Narvaez P., Racioppi A., Kwapil T.R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Randers L., Krakauer K., Glenthoj L.B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Delespaul P.A., RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, MUMC+: MA Psychiatrie (3), RS: MHeNs - R2 - Mental Health, and MUMC+: Hersen en Zenuw Centrum (3)

Subjects
Research design, Psychosis, INFORMATION, IMPACT, Applied psychology, MEDLINE, Assessor selection, Pre-training inter-rater reliability, Psychosis instruments, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Biological Psychiatry, ComputingMilieux_MISCELLANEOUS, Observer Variation, REPRODUTIBILIDADE DE RESULTADOS, business.industry, Pre-training inter-rater reliability, Reproducibility of Results, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Inter-rater reliability, Assessor selection, TRIALS, Psychotic Disorders, Research Design, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MEASUREMENT ERROR, business, Observer variation, 030217 neurology & neurosurgery, Psychosis instruments
Abstract

International audience

Published
2019
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43. Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study

Author

Misra, Supriya, Gelaye, Bizu, Koenen, Karestan C, Williams, David R, Borba, Christina PC, Quattrone, Diego, Di Forti, Marta, La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Berardi, Domenico, Szöke, Andrei, Arango, Celso, Tortelli, Andrea, De Haan, Lieuwe, Velthorst, Eva, Bobes, Julio, Bernardo, Miguel, Sanjuán, Julio, Santos, Jose Luis, Arrojo, Manuel, Del-Ben, Cristina Marta, Menezes, Paulo Rossi, Selten, Jean-Paul, Jones, Peter B, Kirkbride, James B, EU-GEI WP2 Group, Rutten, Bart PF, Van Os, Jim, Murray, Robin M, Gayer-Anderson, Charlotte, Morgan, Craig, Misra S., Gelaye B., Koenen K.C., Williams D.R., Borba C.P.C., Quattrone D., Di Forti M., La Cascia C., La Barbera D., Tarricone I., Berardi D., Szoke A., Arango C., Tortelli A., de Haan L., Velthorst E., Bobes J., Bernardo M., Sanjuan J., Santos J.L., Arrojo M., Del-Ben C.M., Menezes P.R., Selten J.-P., Jones P.B., Kirkbride J.B., Rutten B.P.F., Os J., Murray R.M., Gayer-Anderson C., Morgan C., Supriya Misra, Bizu Gelaye, Karestan C. Koenen, David R. Williams, Christina P.C. Borba, Diego Quattrone, Marta Di Forti, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Andrei Szöke, Celso Arango, Andrea Tortelli, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel Bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B. Jones, James B. Kirkbride, EU-GEI WP2 Group, Bart P.F. Rutten, Jim van Os, Robin M. Murray, Charlotte Gayer-Anderson, Craig Morgan, Misra, Supriya [0000-0003-0389-1227], Quattrone, Diego [0000-0002-6051-8309], Bobes, Julio [0000-0003-2187-4033], Bernardo, Miguel [0000-0001-8748-6717], Menezes, Paulo Rossi [0000-0001-6330-3314], Kirkbride, James B [0000-0003-3401-0824], Murray, Robin M [0000-0003-0829-0519], Apollo - University of Cambridge Repository, Psychiatrie & Neuropsychologie, MUMC+: MA Psychiatrie (3), RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R2 - Mental Health, MUMC+: Hersen en Zenuw Centrum (3), APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Adult Psychiatry

Subjects
ESTUDO DE CASO, STRESS, CHILDHOOD, lcsh:Medicine, childhood adversities, psychosi, Parental Death, 0302 clinical medicine, Psicosi en els infants, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Medicine, early parental death, psychosis, Dol, RACE, General Medicine, Infants Salut mental, childhood adversitie, Esquizofrènia, Maternal death, HEALTH, case-control, early bereavement, DISORDERS, Offspring, DISADVANTAGE, ethnic minorities, ethnic minoritie, Article, Odds, 03 medical and health sciences, BEREAVEMENT, Journal Article, Mortalitat, Psiquiatria, Mortality, Risk factor, Settore MED/25 - Psichiatria, METAANALYSIS, multi-country, business.industry, MORTALITY, lcsh:R, Case-control study, Odds ratio, medicine.disease, Confidence interval, 030227 psychiatry, population-based, schizophrenia, Psychoses in children, business, 030217 neurology & neurosurgery, Bereavement, Demography
Abstract

Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child’s age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02−28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10−8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.

Published
2019
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