27 results on '"Ruth Elder"'
Search Results
2. Development of Self-Efficacy Questionnaire for Chinese Family Caregivers
- Author
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Zhang, Shu-Ying, Edwards, Helen, Yates, Patsy, Ruth, Elder, and Guo, Qi Hao
- Published
- 2012
- Full Text
- View/download PDF
3. Detection of SARS-CoV-2 BA.2.86 by lateral flow devices
- Author
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Abbie Bown, Angela Sweed, Matthew Catton, Joshua Nelthorpe-Cowne, Hermione Conti-Frith, Ruth Elderfield, Jacob Terrey, Hamsa Abib, Caleb Lui, Ella Fisher, Kevin R. Bewley, Naomi S. Coombes, Donna Robinson, Somya Agrawal, Bassam Hallis, Edward Blandford, Tom Fowler, Deborah A. Williamson, and Richard Vipond
- Subjects
SARS-COV-2 ,BA.2.86 ,lateral flow device ,LFD ,Infectious and parasitic diseases ,RC109-216 - Abstract
We evaluated the performance of 12 lateral flow devices by assessing their analytical sensitivity for SARS-CoV-2 variant BA.2.86. Kits from ACON, Orient Gene, Xiamen Biotime, Getein, and SureScreen detected variant BA.2.86 to sufficient sensitivity levels, comparable to those observed with previous Omicron variants. The stocks of lateral flow devices currently held by the UK government do not currently need changing for deployment for this variant.
- Published
- 2024
- Full Text
- View/download PDF
4. Using Copac data to benchmark collections
- Author
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Diana Massam and Ruth Elder
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Service (systems architecture) ,Computer science ,05 social sciences ,Benchmarking ,Library and Information Sciences ,Data science ,Collections management ,Business as usual ,Collection analysis ,World Wide Web ,Work (electrical) ,Benchmark (surveying) ,Collection management ,0509 other social sciences ,050904 information & library sciences - Abstract
Purpose – The Copac Collections Management (CCM) project has been underway since 2011 with the goal of exploring how Copac can make a real difference for collection managers. By making Copac data work harder and building prototype collection analysis features on its extensive database, the collections management tools can provide valuable information from the catalogues of the UK’s major research libraries. The paper aims to discuss these issues. Design/methodology/approach – Developed to support staff in collection management activities the CCM tools offer a web-based collection management support service. It is a “grass roots” project designed to meet the needs of library practitioners and its development has been a community-based collaboration with extensive design input, consultation, feedback and support from the wider library community. Findings – This paper presents a case study showing how the tools are now embedded into “business as usual” at the University of York library. The case study reflects on how York is using the tools to assist: identify collection strengths and contribute to the identification of “unique and distinctive collections”; identify collection gaps and produce lists of potential titles for purchase; inform stock editing policies; review and prioritize work on “hidden collections”. The paper outlines the benefits of using the tools and considers lessons learnt. Originality/value – The paper offers an overall view of the tools and the potential uses by the UK higher education community. The case study will be of interest to libraries in exploring new ways to approach collection management issues, with a view to making efficient use of available resources.
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- 2016
- Full Text
- View/download PDF
5. Using RDA to Improve User Experience. A Report of the ALCTS Catalog Form and Function Interest Group Meeting. American Library Association Annual Conference, Las Vegas, June 2014
- Author
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Ruth Elder and Kelsey Brett
- Subjects
Marketing buzz ,Las vegas ,business.industry ,Association (object-oriented programming) ,Library science ,Cataloging ,Library and Information Sciences ,Computer Science Applications ,World Wide Web ,User experience design ,Form and function ,Political science ,Interest group ,Resource Description and Access ,business - Abstract
In the world of cataloging, Resource Description and Access (RDA) is all the buzz. In the past couple of years, it has been difficult to have a discussion on cataloging practices without bringing u...
- Published
- 2015
- Full Text
- View/download PDF
6. Collaboration at the Troy University Libraries
- Author
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Jana Slay, Ruth Elder, Olga Casey, and Erin E. Boyd
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World Wide Web ,University campus ,Engineering ,Consistency (negotiation) ,Web 2.0 ,business.industry ,Library science ,Cataloging ,Library and Information Sciences ,business ,ComputingMilieux_MISCELLANEOUS - Abstract
With relatively new staff in all the Troy University campus libraries technical services departments, it was critical to collaborate on policies and procedures for consistency. Developing an online manual housed on a wiki that could be used and contributed to by staff on all three campuses was essential to this goal. Multi-campus meetings and online discussions are additional methods we use to promote collaboration. This article will include a literature review of collaboration and wikis along with methods the Troy University Libraries Technical Services departments are using to establish communication across the campuses.
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- 2013
- Full Text
- View/download PDF
7. Changing to learner-centred education: Challenges experienced by nurse educators in Taiwan
- Author
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Ruth Elder, Ching-Kuei Chiang, and Helen M. Chapman
- Subjects
Process (engineering) ,business.industry ,Teaching ,Taiwan ,Nurse educator ,Psychiatric Nursing ,Organizational Innovation ,Education ,Asian People ,Attitude ,Faculty, Nursing ,Pedagogy ,ComputingMilieux_COMPUTERSANDEDUCATION ,Humans ,Medicine ,Curriculum ,Health Services Research ,Staff Development ,Nurse education ,Action research ,Learner centered ,business ,General Nursing ,Research data - Abstract
This paper reports the challenges experienced by nurse educators in changing a teacher-centred, content-driven approach to teaching and learning to a learner-centred, process-driven approach within a School of Nursing in Taiwan. While a general movement towards a learner-centred approach was achieved, the curriculum transformation process was complex and inevitably slow with many challenges. First the study is outlined, with the key challenges experienced by the participating nurse educators explicated and illuminated with excerpts drawn from the research data. This is followed by a discussion of possible reasons for the challenges and how they were overcome and the transition process from teacher-centred to learner-centred education facilitated.
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- 2010
- Full Text
- View/download PDF
8. Supporting mature-aged students from a low socioeconomic background
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Jennifer Fraser, Katherine M. White, Megan J. Tones, and Ruth Elder
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Student perceptions ,Medical education ,Higher education ,business.industry ,education ,Service use ,Sample (statistics) ,Audit ,Focus group ,Education ,Pedagogy ,Survey data collection ,Psychology ,business ,Socioeconomic status - Abstract
The aim of the current study was to examine mature-aged student perceptions of university support services and barriers to study. Using a mixed methods approach, interviews and focus groups were conducted with mature-aged students to identify barriers to study, knowledge and use of current student support services, and suggestions to improve upon these services. From these data and an audit of university support services, an online survey was created to examine study barriers and patterns of support service use, as well as, perceptions of proposed support services not currently offered by the university within a larger sample of mature-aged students. Analysis of survey data indicated distinct patterns of barriers and support service use according to socioeconomic status as well as other demographic factors such as, age and enrolment status. Study findings are discussed in terms of generating support services for the retention of mature-aged students of low socioeconomic status and for the retention of mature-aged students in general.
- Published
- 2009
- Full Text
- View/download PDF
9. Mental Health Nursing E-Book : Mental Health Nursing E-Book
- Author
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Ruth Elder, Katie Evans, Debra Nizette, Steve Trenoweth, Ruth Elder, Katie Evans, Debra Nizette, and Steve Trenoweth
- Subjects
- Psychiatric nursing--Handbooks, manuals, etc
- Abstract
This exciting new book offers a contemporary manual for the mental health nurse within a mental health care system that is increasingly focused on recovery. Mental Health Nursing incorporates recent policy changes that place a greater emphasis on person-centred and social caring, whilst retaining a strong evidence base. The holistic, skills-based approach helps the student and the beginning practitioner to understand the complex causation of mental illness, its diagnosis, effective interventions and treatments, and the client's experience of mental illness. - Broad, yet in-depth, examination of the essential features of contemporary mental health nursing practice - A manual for practice - a skills-based approach provides clear guidance to novices on how to complete essential mental health nursing roles -'Critical Thinking Challenges'based on Case Histories provide a realistic context -'Nurse's Stories'explore the reality of mental health nursing care - On-line resources guide the reader to reflect upon the essential content and ideas contained within each chapter
- Published
- 2014
10. The effectiveness of interventions in the prevention and management of aggressive behaviours in patients admitted to an acute hospital setting
- Author
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Anne M. Chang, Jo Wu, Ruth Elder, and Kathryn Kynoch
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medicine.medical_specialty ,Workplace violence ,business.industry ,Best practice ,Psychological intervention ,Risk management tools ,Verbal abuse ,Body language ,Nonverbal communication ,Family medicine ,medicine ,Anxiety ,medicine.symptom ,Psychiatry ,business ,General Nursing - Abstract
Review Question: This systematic review seeks to establish what is best practice in prevention and management of aggressive behaviours in patients admitted to an acute hospital setting. More specifically, the objectives are to identify; 1) What are the most effective interventions in the prevention of aggressive behaviours in patients admitted to an acute hospital setting? 2) What are the most effective interventions in the management of aggressive behaviours in patients admitted to an acute hospital setting? Inclusion Criteria: Types of participants: This review will consider studies that include adult patients admitted to an acute hospital setting who exhibit aggressive behaviours. Aggressive behaviours will include verbal abuse, non-verbal abuse, violent behaviours and assault. Types of interventions: All studies evaluating the following interventions will be considered for inclusion in the review: Administration of PRN prescribed medications Restraining Clinician behaviours including: - Verbal communication techniques - Use of body language - Prevention and recognition strategies (eg. use of risk assessment tools) - Staff attitudes and skills Environmental controls (eg. minimising light, noise and conversations) Setting of limits for patients to follow Increase in staff numbers Type of outcome (if any): This component of the review will consider studies that include the following outcomes: Aggressive behaviour Staff injuries Patients absconding Stress/anxiety levels among staff Patient injuries Length of hospital stay Early detection of aggressive behaviours
- Published
- 2007
- Full Text
- View/download PDF
11. Book Reviews
- Author
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JOHN O'BRIEN, RUTH ELDER, ANNE JUNOR, ROBIN PRICE, ALISON PRESTON, and SUZANNE HAMMOND
- Published
- 2002
- Full Text
- View/download PDF
12. Psychiatric & Mental Health Nursing - E-Book
- Author
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Ruth Elder, Katie Evans, Debra Nizette, Ruth Elder, Katie Evans, and Debra Nizette
- Abstract
The new edition of Psychiatric and Mental Health Nursing focuses on practice in mental health and psychiatric care integrating theory and the realities of practice. Mental wellness is featured as a concept, and the consideration of a range of psychosocial factors helps students contextualise mental illness and psychiatric disorders. The holistic approach helps the student and the beginning practitioner understand the complex causation of mental illness, its diagnosis, effective interventions and treatments, and the client's experience of mental illness.
- Published
- 2011
13. Engaging undergraduate nursing students in face-to-face tutorials
- Author
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Margaret Wheeler, Carol Windsor, Helen M. Chapman, Elizabeth Forster, Joanne Foster, Ruth Elder, and Peter Lewis
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Undergraduate nursing ,media_common.quotation_subject ,Interprofessional Relations ,education ,Economic shortage ,Tutorials ,Bachelor ,Education ,Face-to-face ,ComputingMilieux_COMPUTERSANDEDUCATION ,Medicine ,Humans ,Nurse education ,Disengagement theory ,General Nursing ,Qualitative Research ,media_common ,Medical education ,Engagement ,business.industry ,Teaching ,Education, Nursing, Baccalaureate ,General Medicine ,Focus group ,Nursing Education Research ,Students, Nursing ,Involvement ,business - Abstract
Chronic nursing shortages have placed increasing pressure on many nursing schools to recruit greater numbers of students with the consequence of larger class sizes. Larger class sizes have the potential to lead to student disengagement. This paper describes a case study that examined the strategies used by a group of nursing lecturers to engage students and to overcome passivity in a Bachelor of Nursing programme. A non-participant observer attended 20 tutorials to observe five academics deliver four tutorials each. Academics were interviewed both individually and as a group following the completion of all tutorial observations. All observations, field notes, interviews and focus groups were coded separately and major themes identified. From this analysis two broad categories emerged: getting students involved; and engagement as a struggle. Academics used a wide variety of techniques to interest and involve students. Additionally, academics desired an equal relationship with students. They believed that both they and the students had some power to influence the dynamics of tutorials and that neither party had ultimate power. The findings of this study serve to re-emphasise past literature which suggests that to engage students, the academics must also engage.
- Published
- 2010
14. Overcoming challenges to collaboration: nurse educators' experiences in curriculum change
- Author
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Ching Kuei Chiang, Helen M. Chapman, and Ruth Elder
- Subjects
Models, Educational ,Time Factors ,Process (engineering) ,Attitude of Health Personnel ,Interprofessional Relations ,Taiwan ,Organizational culture ,Psychiatric Nursing ,Nursing Methodology Research ,Education ,Unit (housing) ,Conflict, Psychological ,Medicine ,Humans ,Models, Nursing ,Cooperative Behavior ,Program Development ,Curriculum ,General Nursing ,Qualitative Research ,Medical education ,business.industry ,Nurse educator ,Health services research ,Education, Nursing, Baccalaureate ,Dissent and Disputes ,Organizational Culture ,Organizational Innovation ,Nursing Education Research ,Faculty, Nursing ,Health Services Research ,business ,Qualitative research ,Meaning (linguistics) - Abstract
This article describes challenges to effective collaboration encountered by nurse educators as they transformed a unit within a school of nursing in Taiwan. This study introduced collaborative action research as a vehicle for curriculum change. Although the team achieved positive outcomes in transforming a unit, the collaborative process was complex with four major challenges: meaning, time, work culture, and conflicting views. This article provides an overview of the study, and the major challenges posed by working together are expounded and illustrated with excerpts drawn from the study data. Possible reasons for the challenges, how these challenges were overcome, and facilitation of the collaborative process are discussed.
- Published
- 2009
15. Clinical placements in residential aged care facilities: the impact on nursing students' perception of aged care and the effect on career plans
- Author
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Jennifer, Abbey, Brian, Abbey, Pamela, Bridges, Ruth, Elder, Pam, Lemcke, Jacki, Liddle, and Robert, Thornton
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Career Choice ,Attitude of Health Personnel ,Internship, Nonmedical ,Education, Nursing, Baccalaureate ,Pilot Projects ,Nursing Homes ,Nursing Education Research ,Social Perception ,Workforce ,Homes for the Aged ,Humans ,Professional Autonomy ,Students, Nursing ,Clinical Competence ,Queensland ,Qualitative Research - Abstract
Undergraduate nursing students have often found clinical placements in aged care unsatisfactory and/or unsettling, dissuading them from considering aged care as an employment option on graduation. This study asked which elements of the clinical placement experience produced that outcome; and what changes could yield more positive outcomes.A descriptive qualitative pilot study was carried out in late 2003. A combination of nominal groups and semi-structured interviews was used with students and experienced nurses to identify commonalities and variations in issues nominated as important and in the views expressed on those issues. Transcripts were independently analysed by two experienced investigators. Themes identified were discussed among the researchers.Fourteen volunteer undergraduate nursing students, all of whom had completed clinical placements in residential care and some of whom had prior experience in such facilities, participated in the nominal groups. Twelve registered nurses who had acted as clinical teachers in aged care facilities were interviewed.Perceived issues included: unexamined assumptions about nursing's core skills; lack of pre-placement orientation to the residential care environment; the appeal of and apprehension aroused by autonomous practice; and status, income and career progression considerations.Analysis of the sometimes ambivalent and conflicting views expressed pointed to possible changes, all within the domain of training and employing institutions, capable of bringing submerged issues to the surface for examination and resolution as part of raising student understanding of gerontology as a demanding specialty and residential care as a rewarding career.
- Published
- 2006
16. Hassles and uplifts associated with caring for people with cognitive impairment in community settings
- Author
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Judy Wollin, Ruth Elder, Charmine E. J. Härtel, Wayne Sanderson, and Nancy Spencer
- Subjects
Adult ,Male ,Attitude of Health Personnel ,Home Nursing ,Nursing Methodology Research ,Nurse's Role ,Job Satisfaction ,Nursing Assistants ,Surveys and Questionnaires ,Adaptation, Psychological ,Humans ,Family ,Cognitive impairment ,Burnout, Professional ,Middle Aged ,Community Health Nursing ,Caregivers ,Job Description ,Healthcare settings ,Community setting ,Job satisfaction ,Female ,Nursing Staff ,Cognitively impaired ,Queensland ,Pshychiatric Mental Health ,Psychology ,Cognition Disorders ,Attitude to Health ,Clinical psychology - Abstract
In this study we explored the hassles and uplifts (i.e. negative and positive emotional events) experienced by registered nurses, nursing assistants and personal carers working with people with cognitive impairment in community and residential healthcare settings in Brisbane, Queensland, Australia. The primary aim of the research was to explore what aspects of caring for cognitively impaired clients hassles nurses, what helps to relieve these hassles, what aspects of this work nurses find rewarding and what detracts from those rewards, as well as the intensity with which each of these aspects were felt. A questionnaire developed to explore hassles and uplifts at work was administered and 57 responses obtained. Results indicated that caring for the cognitively impaired client provides many uplifts for nurses and few hassles. However, the hassles that occurred were of high importance. This paper will be of interest to managers, nurses and carers in settings where there are people with cognitive impairment as well as scholars, who may find that assessing emotional hassles and uplifts provides additional insights into other areas of nursing.
- Published
- 2004
17. Mammograms and Pap smears for Australian deaf women
- Author
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Judy Wollin and Ruth Elder
- Subjects
medicine.medical_specialty ,Health Knowledge, Attitudes, Practice ,Uterine Cervical Neoplasms ,Convenience sample ,Breast Neoplasms ,Deafness ,computer.software_genre ,Cervical cancer screening ,Health services ,Time frame ,Surveys and Questionnaires ,otorhinolaryngologic diseases ,Medicine ,Humans ,Mass Screening ,Vaginal Smears ,Pap smears ,Cervical screening ,Oncology (nursing) ,business.industry ,Australia ,Oncology ,Family medicine ,Physical therapy ,Female ,business ,computer ,Interpreter ,Mammography ,Papanicolaou Test - Abstract
This study aimed to assess baseline knowledge about mammograms and pap smears among Australian Deaf women, to investigate their participation in breast and cervical cancer screening services, and to explore, where relevant, their perceptions about their access to breast and cervical screening services. An interview schedule was developed, and a convenience sample of 13 Deaf women was interviewed face-to-face by the first researcher with an accredited Auslan interpreter. The Deaf women's knowledge about mammograms and Pap smears often was incomplete. However, most of the eligible women had undergone a mammogram and had been rescreened within the recommended time frame. Although most had received a Pap smear, some were not attending as recommended by the Cancer Council of Australia. This exploration into the experiences of Deaf women can prompt all nurses to consider the needs of particular minorities and the barriers they may face to participate fully in health services.
- Published
- 2004
18. Psychiatric & Mental Health Nursing - E-Book
- Author
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Ruth Elder, Katie Evans, Debra Nizette, Ruth Elder, Katie Evans, and Debra Nizette
- Subjects
- Psychiatric nursing, Psychiatric nursing--New Zealand, Psychiatric nursing--Australia
- Abstract
The new edition of Psychiatric and Mental Health Nursing focuses on practice in mental health and psychiatric care integrating theory and the realities of practice. Mental wellness is featured as a concept, and the consideration of a range of psychosocial factors helps students contextualise mental illness and psychiatric disorders. The holistic approach helps the student and the beginning practitioner understand the complex causation of mental illness, its diagnosis, effective interventions and treatments, and the client's experience of mental illness.
- Published
- 2009
19. Differences in ethical attitudes between registered nurses and medical students
- Author
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Gail M. Williams, John Price, and Ruth Elder
- Subjects
Adult ,Male ,medicine.medical_specialty ,Surgical nursing ,Students, Medical ,Attitude of Health Personnel ,education ,Nursing Methodology Research ,Nursing Staff, Hospital ,0603 philosophy, ethics and religion ,Patient care ,Conflict, Psychological ,03 medical and health sciences ,Sex Factors ,Nursing ,Surveys and Questionnaires ,Work setting ,Ethics, Nursing ,medicine ,Humans ,Potential source ,Ethics, Medical ,Analysis of Variance ,030504 nursing ,Social Identification ,business.industry ,Perspective (graphical) ,Socialization ,Physician-Nurse Relations ,06 humanities and the arts ,Middle Aged ,Viewpoints ,Issues, ethics and legal aspects ,Family medicine ,Ethics education ,Female ,060301 applied ethics ,Queensland ,0305 other medical science ,business - Abstract
In this study we compared the ethical attitudes of a group of experienced, predominantly female, registered nurses (n = 67) with those of a group of final year, mixed sex, medical students (n = 125). The purpose was to determine the basis of differences in attitudes that could lead to ethical disagreements between these two groups when they came to work together. A questionnaire developed to explore ethical attitudes was administered and the responses of the two groups were compared using t-tests. Because of the preponderance of females among the nurses an analysis of variance of the gender-adjusted scores for each group was also carried out. On comparing the responses, the nurses differed significantly from the medical students in a number of ethical domains. A potential source of conflict between these two groups is that the nurses were inclined to adopt the perspective of patients but the medical students identified with their profession. When corrected for the effects of gender, the differences persisted, indicating that it was discipline that determined the differences. We recommend that students of nursing and medicine receive ethics education together, and that more open dialogue between doctors and nurses with respect to their different ethical viewpoints is needed in the work setting. This article will be of interest to educators of students of medicine and nursing, as well as to doctors and nurses who are eager to improve their professional relations and thereby improve patient care.
- Published
- 2003
20. Mental Health and Illness in Australia and New Zealand
- Author
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Ruth Elder, Katie Evans, Debra Nizette, Bradley, Patricia, De, Souza, Ruth Elder, Katie Evans, Debra Nizette, Bradley, Patricia, and De, Souza
- Published
- 2013
21. Preliminary reliability and validity testing of a Self-Efficacy Questionnaire for Chinese Family Caregivers
- Author
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Zhang, Shu-Ying, primary, Edwards, Helen, additional, Yates, Patsy, additional, Ruth, Elder, additional, and Guo, Qihao, additional
- Published
- 2013
- Full Text
- View/download PDF
22. Self-Efficacy Questionnaire for Chinese Family Caregivers
- Author
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Zhang, Shu-Ying, primary, Edwards, Helen, additional, Yates, Patsy, additional, Ruth, Elder, additional, and Guo, Qi Hao, additional
- Published
- 2012
- Full Text
- View/download PDF
23. Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.
- Author
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Claire Scott, Jayakanth Kankanala, Toshana L Foster, Daniel H Goldhill, Peng Bao, Katie Simmons, Marieke Pingen, Matthew Bentham, Elizabeth Atkins, Eleni Loundras, Ruth Elderfield, Jolyon K Claridge, Joseph Thompson, Peter R Stilwell, Ranjitha Tathineni, Clive S McKimmie, Paul Targett-Adams, Jason R Schnell, Graham P Cook, Stephen Evans, Wendy S Barclay, Richard Foster, and Stephen Griffin
- Subjects
Immunologic diseases. Allergy ,RC581-607 ,Biology (General) ,QH301-705.5 - Abstract
Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alternative clinically proven antiviral target, yet a near-ubiquitous S31N polymorphism in M2 evokes resistance to licensed adamantane drugs. Hence, inhibitors capable of targeting N31 containing M2 (M2-N31) are highly desirable. Rational in silico design and in vitro screens delineated compounds favouring either lumenal or peripheral M2 binding, yielding effective M2-N31 inhibitors in both cases. Hits included adamantanes as well as novel compounds, with some showing low micromolar potency versus pandemic "swine" H1N1 influenza (Eng195) in culture. Interestingly, a published adamantane-based M2-N31 inhibitor rapidly selected a resistant V27A polymorphism (M2-A27/N31), whereas this was not the case for non-adamantane compounds. Nevertheless, combinations of adamantanes and novel compounds achieved synergistic antiviral effects, and the latter synergised with the neuraminidase inhibitor (NAi), Zanamivir. Thus, site-directed drug combinations show potential to rejuvenate M2 as an antiviral target whilst reducing the risk of drug resistance.
- Published
- 2020
- Full Text
- View/download PDF
24. Mouse Models of Influenza Infection with Circulating Strains to Test Seasonal Vaccine Efficacy
- Author
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Helen T. Groves, Jacqueline U. McDonald, Pinky Langat, Ekaterina Kinnear, Paul Kellam, John McCauley, Joanna Ellis, Catherine Thompson, Ruth Elderfield, Lauren Parker, Wendy Barclay, and John S. Tregoning
- Subjects
Influenza Vaccines ,mouse models ,Infection ,Antibodies ,Viral ,vaccine drift ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Influenza virus infection is a significant cause of morbidity and mortality worldwide. The surface antigens of influenza virus change over time blunting both naturally acquired and vaccine induced adaptive immune protection. Viral antigenic drift is a major contributing factor to both the spread and disease burden of influenza. The aim of this study was to develop better infection models using clinically relevant, influenza strains to test vaccine induced protection. CB6F1 mice were infected with a range of influenza viruses and disease, inflammation, cell influx, and viral load were characterized after infection. Infection with circulating H1N1 and representative influenza B viruses induced a dose-dependent disease response; however, a recent seasonal H3N2 virus did not cause any disease in mice, even at high titers. Viral infection led to recoverable virus, detectable both by plaque assay and RNA quantification after infection, and increased upper airway inflammation on day 7 after infection comprised largely of CD8 T cells. Having established seasonal infection models, mice were immunized with seasonal inactivated vaccine and responses were compared to matched and mismatched challenge strains. While the H1N1 subtype strain recommended for vaccine use has remained constant in the seven seasons between 2010 and 2016, the circulating strain of H1N1 influenza (2009 pandemic subtype) has drifted both genetically and antigenically since 2009. To investigate the effect of this observed drift on vaccine induced protection, mice were immunized with antigens from A/California/7/2009 (H1N1) and challenged with H1N1 subtype viruses recovered from 2009, 2010, or 2015. Vaccination with A/California/7/2009 antigens protected against infection with either the 2009 or 2010 strains, but was less effective against the 2015 strain. This observed reduction in protection suggests that mouse models of influenza virus vaccination and infection can be used as an additional tool to predict vaccine efficacy against drift strains.
- Published
- 2018
- Full Text
- View/download PDF
25. Dying in the U.S.A
- Author
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Ruth Elder
- Subjects
Terminal Care ,Attitude to Death ,Cognition ,Life Expectancy ,Family ,Disclosure ,Professional-Patient Relations ,General Nursing ,United States - Abstract
Resume Chaque societe a ses facons etablies de traiter la mort … aide aux endeuilles, sort fait au cadavre, dispersion de la propriete, remplacement dans les fonctions naguere assumees par le defunt … Notre societe n'y fait pas exception. Un souci nouveau s'est toutefois fait jour ces dernieres annees et c'est le comportement devant le deces proprement dit. Meme si nous resolvons un des principaux problemes du passe, la mort prematuree, nous sommes confrontes avec des aspects nouveaux. Ceux-ci sont la prolongation de la vie par notre technologie nouvelle, le droit de l'homme a accelerer le processus de sa propre mort, le droit a s'affranchir de la douleur au prix d'un abregement de la vie, l'isolement et la solitude de ceux qui meurent dans nos etablissements hospitaliers et le traitement impersonnel des proches qui s'appliquent a alleger les derniers jours de ceux qu'ils aiment.
- Published
- 1973
26. The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.
- Author
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Ming Liu, Mandy Ka-Han Lam, Qinfen Zhang, Ruth Elderfield, Wendy S Barclay, and Pang-Chui Shaw
- Subjects
Medicine ,Science - Abstract
Influenza nucleoprotein (NP) is a major component of the ribonucleoprotein (vRNP) in influenza virus, which functions for the transcription and replication of viral genome. Compared to the nucleoprotein of influenza A (ANP), the N-terminal region of influenza B nucleoprotein (BNP) is much extended. By virus reconstitution, we found that the first 38 residues are essential for viral growth. We further illustrated the function of BNP by mini-genome reconstitution, fluorescence microscopy, electron microscopy, light scattering and gel shift. Results show that the N terminus is involved in the formation of both higher homo-oligomers of BNP and BNP-RNA complex.
- Published
- 2015
- Full Text
- View/download PDF
27. New Haven Survey of Joint Diseases: XIV. Social Class and Behavior in Response to Symptoms of Osteoarthrosis
- Author
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Ruth Elder and Roy M. Acheson
- Subjects
business.industry ,media_common.quotation_subject ,General Medicine ,Population health ,Public administration ,Social mobility ,Social class ,Economic Justice ,Interpersonal relationship ,Medicine ,Ideology ,business ,Social psychology ,Socioeconomic status ,Class consciousness ,media_common - Abstract
A characteristic of social systems that has long fascinated scholars is the division of society into classes or strata based on variations in wealth, power and prestige. The United States is noted for its egalitarian ideology, its belief in the existence of a greater opportunity for social mobility than in other countries, and for its lack of class consciousness. Nevertheless, economic position varies widely within American society and location in the economic spectrum affects many aspects of social behavior and life opportunities. Variations in life styles, mating and sexual behavior, child-rearing customs, values and so forth have all been linked to socioeconomic or social class position.1-3 The evidence indicates that response to illness and receipt of medical care are also influenced by position in this stratification system4-6 although the data available are not consistent. Knowledge of the impact of social class position on health is especially important because, as Parsons7 has pointed out, education and health are fundamental to achievement because they condition the individual's capacity to exploit whatever opportunities society has to offer. Therefore, access to health and educational services becomes a central problem of justice in a society such as this, with its emphasis on achievement, and equality of opportunity to achieve. Knowledge of the factors
- Published
- 1970
- Full Text
- View/download PDF
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