33 results on '"Russo, Rosellina"'
Search Results
2. Magnetic resonance imaging-derived parameters to predict response to regorafenib in recurrent glioblastoma
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Martucci, Matia, Ferranti, Andrea Maurizio, Schimperna, Francesco, Infante, Amato, Magnani, Francesca, Olivi, Alessandro, D’Alessandris, Quintino Giorgio, Gessi, Marco, Chiesa, Silvia, Mazzarella, Ciro, Russo, Rosellina, Giordano, Carolina, and Gaudino, Simona
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- 2023
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3. New onset of Susac syndrome after mRNA COVID-19 vaccine: a case report
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Bianco, Assunta, Colò, Francesca, Falso, Silvia, Russo, Rosellina, Carlà, Matteo Maria, Minucci, Angelo, Cadoni, Gabriella, Lucchini, Matteo, Cicia, Alessandra, Calabresi, Paolo, and Mirabella, Massimiliano
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- 2023
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4. Clinical and NGS predictors of response to regorafenib in recurrent glioblastoma
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Chiesa, Silvia, Mangraviti, Antonella, Martini, Maurizio, Cenci, Tonia, Mazzarella, Ciro, Gaudino, Simona, Bracci, Serena, Martino, Antonella, Della Pepa, Giuseppe M., Offi, Martina, Gessi, Marco, Russo, Rosellina, Martucci, Matia, Beghella Bartoli, Francesco, Larocca, Luigi M., Lauretti, Liverana, Olivi, Alessandro, Pallini, Roberto, Balducci, Mario, and D’Alessandris, Quintino Giorgio
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- 2022
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5. Deep Sedation in Lateral Position for Preterm Infants during Cerebral Magnetic Resonance Imaging: a Prospective Observational Study
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Sbaraglia, Fabio, primary, Gaudino, Simona, additional, Tiberi, Eloisa, additional, Maiellare, Federica, additional, Spinazzola, Giorgia, additional, Garra, Rossella, additional, Sala, Filomena Della, additional, Micci, Daniela Maria, additional, Russo, Rosellina, additional, Riitano, Francesca, additional, Ferrara, Giuseppe, additional, Vento, Giovanni, additional, and Rossi, Marco, additional
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- 2024
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6. Head CT Scans in the Emergency Department during the COVID-19 Pandemic: Use or Overuse?
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Covino, Marcello, primary, Piccioni, Andrea, additional, Merra, Giuseppe, additional, Giordano, Carolina, additional, Russo, Rosellina, additional, Infante, Amato, additional, Ausili Cefaro, Luca, additional, Natale, Luigi, additional, Franceschi, Francesco, additional, and Gaudino, Simona, additional
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- 2024
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7. Head CT Scans in the Emergency Department during the COVID-19 Pandemic: Use or Overuse?
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Covino, Marcello, Piccioni, Andrea, Merra, Giuseppe, Giordano, Carolina, Russo, Rosellina, Infante, Amato, Ausili Cefaro, Luca, Natale, Luigi, Franceschi, Francesco, Gaudino, Simona, Covino, Marcello (ORCID:0000-0002-6709-2531), Natale, Luigi (ORCID:0000-0002-7949-5119), Gaudino, Simona (ORCID:0000-0003-1681-4343), Covino, Marcello, Piccioni, Andrea, Merra, Giuseppe, Giordano, Carolina, Russo, Rosellina, Infante, Amato, Ausili Cefaro, Luca, Natale, Luigi, Franceschi, Francesco, Gaudino, Simona, Covino, Marcello (ORCID:0000-0002-6709-2531), Natale, Luigi (ORCID:0000-0002-7949-5119), and Gaudino, Simona (ORCID:0000-0003-1681-4343)
- Abstract
Background: The COVID-19 pandemic seemed to mainly involve the respiratory system, but it was realized that it could affect any organ, including the CNS. The pandemic has followed a wave-like trend, with its peaks being due to the COVID-19 different variants and the introduction of the vaccine, which led to an apparent reduction in hospitalizations but also brought about perplexities related to its adverse effects. The aim of this study was to analyze the changes in the use of head CT/contrast CT and their impacts on the onset of cerebrovascular disease in our emergency department during the COVID-19 period and the vaccine rollout. Methods: Patients >= 18 years old admitted to our emergency department from January 2018 to September 2021 were enrolled. The patients were divided into three groups. The COVID-19 period included patients who visited our emergency department from 1 March 2020 to 31 January 2021; the vaccine period was considered to range from 1 February 2021 to 30 September 2021. The patients who visited the emergency department from 1 January 2018 to 31 January 2020 were considered the controls. Results: We found an increase in head CT/contrast CT requests during the COVID-19 period and increase in head contrast CT during the vaccine period, without an increase in the incidence of cerebrovascular disease. Conclusions: The uncertainty regarding the possible thrombotic events associated with COVID-19 and its vaccine increased the relative use of head CT/contrast CT by about 20% compared to the control period
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- 2024
8. The Role of Ultrasound in Epicutaneo-Caval Catheter Insertion in Neonates: Systematic Review, Meta-Analysis and Future Perspectives
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D’Andrea, Vito, primary, Cascini, Valentina, additional, Russo, Rosellina, additional, Perri, Alessandro, additional, Prontera, Giorgia, additional, Ancora, Gina, additional, Vento, Giovanni, additional, Lisi, Gabriele, additional, and Barone, Giovanni, additional
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- 2023
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9. 2319: Radionecrosis in stereotactic radiotherapy for resected brain metastases: role of dosimetric indeces
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Dinapoli, Nicola, Lepre, Elisabetta, Bartoli, Francesco Beghella, Bernabucci, Lucrezia, Mazzarella, Ciro, Russo, Rosellina, Schiarelli, Chiara, Martino, Antonella, Perna, Alessandro, Bracci, Serena, Mariani, Silvia, Manfrida, Stefania, Massaccesi, Mariangela, Bertolini, Roberta, Marazzi, Fabio, Olivi, Alessandro, Valentini, Vincenzo, Tagliaferri, Luca, Gambacorta, Maria Antonietta, Gaudino, Simona, and Chiesa, Silvia
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- 2024
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10. Advanced Magnetic Resonance Imaging in the Evaluation of Treated Glioblastoma: A Pictorial Essay
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Martucci, Matia, primary, Russo, Rosellina, additional, Giordano, Carolina, additional, Schiarelli, Chiara, additional, D’Apolito, Gabriella, additional, Tuzza, Laura, additional, Lisi, Francesca, additional, Ferrara, Giuseppe, additional, Schimperna, Francesco, additional, Vassalli, Stefania, additional, Calandrelli, Rosalinda, additional, and Gaudino, Simona, additional
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- 2023
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11. MRI-derived radiomics to guide post-operative management of glioblastoma: Implication for personalized radiation treatment volume delineation
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Chiesa, Silvia, Russo, Rosellina, Beghella Bartoli, Francesco, Palumbo, I, Sabatino, Giovanni, Cannatà, M C, Gigli, Riccardo, Longo, Silvia, Tran, H E, Boldrini, Luca, Dinapoli, Nicola, Votta, C, Cusumano, Davide, Pignotti, Fabrizio, Lupattelli, M, Camilli, F, Della Pepa, Giuseppe Maria, D'Alessandris, G Q, Olivi, Alessandro, Balducci, Mario, Colosimo, Cesare, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Aristei, Cynthia, Gaudino, Simona, Chiesa, S (ORCID:0000-0003-0168-3459), Russo, R, Beghella Bartoli, F, Sabatino, G (ORCID:0000-0002-4227-0434), Gigli, R, Longo, S, Boldrini, L, Dinapoli, N, Cusumano, D, Pignotti, F, Della Pepa, G M (ORCID:0000-0001-8698-3359), Olivi, A (ORCID:0000-0002-4489-7564), Balducci, M (ORCID:0000-0003-0398-9726), Colosimo, C (ORCID:0000-0003-3800-3648), Gambacorta, M A (ORCID:0000-0001-5455-8737), Valentini, V (ORCID:0000-0003-4637-6487), Aristei, C, Gaudino, S (ORCID:0000-0003-1681-4343), Chiesa, Silvia, Russo, Rosellina, Beghella Bartoli, Francesco, Palumbo, I, Sabatino, Giovanni, Cannatà, M C, Gigli, Riccardo, Longo, Silvia, Tran, H E, Boldrini, Luca, Dinapoli, Nicola, Votta, C, Cusumano, Davide, Pignotti, Fabrizio, Lupattelli, M, Camilli, F, Della Pepa, Giuseppe Maria, D'Alessandris, G Q, Olivi, Alessandro, Balducci, Mario, Colosimo, Cesare, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Aristei, Cynthia, Gaudino, Simona, Chiesa, S (ORCID:0000-0003-0168-3459), Russo, R, Beghella Bartoli, F, Sabatino, G (ORCID:0000-0002-4227-0434), Gigli, R, Longo, S, Boldrini, L, Dinapoli, N, Cusumano, D, Pignotti, F, Della Pepa, G M (ORCID:0000-0001-8698-3359), Olivi, A (ORCID:0000-0002-4489-7564), Balducci, M (ORCID:0000-0003-0398-9726), Colosimo, C (ORCID:0000-0003-3800-3648), Gambacorta, M A (ORCID:0000-0001-5455-8737), Valentini, V (ORCID:0000-0003-4637-6487), Aristei, C, and Gaudino, S (ORCID:0000-0003-1681-4343)
- Abstract
BackgroundThe glioblastoma's bad prognosis is primarily due to intra-tumor heterogeneity, demonstrated from several studies that collected molecular biology, cytogenetic data and more recently radiomic features for a better prognostic stratification. The GLIFA project (GLIoblastoma Feature Analysis) is a multicentric project planned to investigate the role of radiomic analysis in GB management, to verify if radiomic features in the tissue around the resection cavity may guide the radiation target volume delineation. Materials and methodsWe retrospectively analyze from three centers radiomic features extracted from 90 patients with total or near total resection, who completed the standard adjuvant treatment and for whom we had post-operative images available for features extraction. The Manual segmentation was performed on post gadolinium T1w MRI sequence by 2 radiation oncologists and reviewed by a neuroradiologist, both with at least 10 years of experience. The Regions of interest (ROI) considered for the analysis were: the surgical cavity +/- post-surgical residual mass (CTV_cavity); the CTV a margin of 1.5 cm added to CTV_cavity and the volume resulting from subtracting the CTV_cavity from the CTV was defined as CTV_Ring. Radiomic analysis and modeling were conducted in RStudio. Z-score normalization was applied to each radiomic feature. A radiomic model was generated using features extracted from the Ring to perform a binary classification and predict the PFS at 6 months. A 3-fold cross-validation repeated five times was implemented for internal validation of the model. ResultsTwo-hundred and seventy ROIs were contoured. The proposed radiomic model was given by the best fitting logistic regression model, and included the following 3 features: F_cm_merged.contrast, F_cm_merged.info.corr.2, F_rlm_merged.rlnu. A good agreement between model predicted probabilities and observed outcome probabilities was obtained (p-value of 0.49 by Hosmer and Lemeshow statistical te
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- 2023
12. Real-Time Ultrasound Tip Location Reduces Malposition and Radiation Exposure during Epicutaneo-Caval Catheter Placement in Neonates
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D'Andrea, Vito, Prontera, Giorgia, Cota, Francesco, Russo, Rosellina, Barone, Giovanni, Vento, Giovanni, D'Andrea, Vito (ORCID:0000-0002-0980-799X), Cota, Francesco (ORCID:0000-0002-9009-3997), Vento, Giovanni (ORCID:0000-0002-8132-5127), D'Andrea, Vito, Prontera, Giorgia, Cota, Francesco, Russo, Rosellina, Barone, Giovanni, Vento, Giovanni, D'Andrea, Vito (ORCID:0000-0002-0980-799X), Cota, Francesco (ORCID:0000-0002-9009-3997), and Vento, Giovanni (ORCID:0000-0002-8132-5127)
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Objective Epicutaneo-caval catheters (ECCs) are essential for the care of sick infants who require long-term medical and nutritional management. The aim of this study was to investigate the use of real-time ultrasound as an alternative to X-rays to reduce the incidence of primary malpositions during catheter insertion.Study Design Data on ECCs were retrospectively collected in a tertiary neonatal intensive care unit. Catheter were analyzed considering the tip location technique (standard chest-abdominal radiograph vs real-time ultrasound)Results A total of 248 ECCs were analyzed. Of these, 118 catheters had primary malposition (47.6%). The tip of 165 catheters was assessed using standard chest-abdominal X-rays and 107 (64.8%) were found to be in an inappropriate location. In the group of 83 catheters that were placed using real-time ultrasound for tip location, only 11 catheters (13.2%) had primary malposition. The rate of malposition among the two groups showed a statistically significant difference ( p < 0.001). Hypothetically, 300 chest X-rays could have been saved if real-time ultrasound had been used to locate the tip, reducing radiation exposure to infants.Conclusion The use of a real-time ultrasound may be beneficial in reducing primary catheter malpositions compared with conventional radiography. In addition, secondary malpositions and catheter-related complications can be monitored over time.
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- 2023
13. Magnetic Resonance Imaging of Primary Adult Brain Tumors: State of the Art and Future Perspectives
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Martucci, Matia, Russo, Rosellina, Schimperna, Francesco, D'Apolito, Gabriella, Panfili, Marco, Grimaldi, Alessandro, Perna, Alessandro, Ferranti, Andrea Maurizio, Varcasia, Giuseppe, Giordano, Carolina, Gaudino, Simona, D’Apolito, Gabriella, Gaudino, Simona (ORCID:0000-0003-1681-4343), Martucci, Matia, Russo, Rosellina, Schimperna, Francesco, D'Apolito, Gabriella, Panfili, Marco, Grimaldi, Alessandro, Perna, Alessandro, Ferranti, Andrea Maurizio, Varcasia, Giuseppe, Giordano, Carolina, Gaudino, Simona, D’Apolito, Gabriella, and Gaudino, Simona (ORCID:0000-0003-1681-4343)
- Abstract
MRI is undoubtedly the cornerstone of brain tumor imaging, playing a key role in all phases of patient management, starting from diagnosis, through therapy planning, to treatment response and/or recurrence assessment. Currently, neuroimaging can describe morphologic and non-morphologic (functional, hemodynamic, metabolic, cellular, microstructural, and sometimes even genetic) characteristics of brain tumors, greatly contributing to diagnosis and follow-up. Knowing the technical aspects, strength and limits of each MR technique is crucial to correctly interpret MR brain studies and to address clinicians to the best treatment strategy. This article aimed to provide an overview of neuroimaging in the assessment of adult primary brain tumors. We started from the basilar role of conventional/morphological MR sequences, then analyzed, one by one, the non-morphological techniques, and finally highlighted future perspectives, such as radiomics and artificial intelligence.
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- 2023
14. Advanced Magnetic Resonance Imaging in the Evaluation of Treated Glioblastoma: A Pictorial Essay
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Martucci, Matia, Russo, Rosellina, Giordano, Carolina, Schiarelli, Chiara, D'Apolito, Gabriella, Tuzza, Laura, Lisi, Francesca, Ferrara, Giuseppe, Schimperna, Francesco, Vassalli, Stefania, Calandrelli, Rosalinda, Gaudino, Simona, D’Apolito, Gabriella, Gaudino, Simona (ORCID:0000-0003-1681-4343), Martucci, Matia, Russo, Rosellina, Giordano, Carolina, Schiarelli, Chiara, D'Apolito, Gabriella, Tuzza, Laura, Lisi, Francesca, Ferrara, Giuseppe, Schimperna, Francesco, Vassalli, Stefania, Calandrelli, Rosalinda, Gaudino, Simona, D’Apolito, Gabriella, and Gaudino, Simona (ORCID:0000-0003-1681-4343)
- Abstract
Simple Summary Glioblastoma is the most common malignant primary tumor of the central nervous system, with a poor prognosis despite many available treatments, including surgery, radiotherapy, and chemotherapy. The evaluation of treatment response is essential to optimize patient outcomes. While structural MRI remains the cornerstone of imaging evaluation, advanced MRI modalities have increasingly become crucial in characterizing treatment effects more comprehensively. The purpose of this pictorial essay is to provide an overview on the role of advanced MRI modalities at the different clinical-therapeutic timepoints, thus helping radiologists and clinicians to be more confident in their applicability in clinical practice and at the proper timepoint. MRI plays a key role in the evaluation of post-treatment changes, both in the immediate post-operative period and during follow-up. There are many different treatment's lines and many different neuroradiological findings according to the treatment chosen and the clinical timepoint at which MRI is performed. Structural MRI is often insufficient to correctly interpret and define treatment-related changes. For that, advanced MRI modalities, including perfusion and permeability imaging, diffusion tensor imaging, and magnetic resonance spectroscopy, are increasingly utilized in clinical practice to characterize treatment effects more comprehensively. This article aims to provide an overview of the role of advanced MRI modalities in the evaluation of treated glioblastomas. For a didactic purpose, we choose to divide the treatment history in three main timepoints: post-surgery, during Stupp (first-line treatment) and at recurrence (second-line treatment). For each, a brief introduction, a temporal subdivision (when useful) or a specific drug-related paragraph were provided. Finally, the current trends and application of radiomics and artificial intelligence (AI) in the evaluation of treated GB have been outlined.
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- 2023
15. The Role of Ultrasound in Epicutaneo-Caval Catheter Insertion in Neonates: Systematic Review, Meta-Analysis and Future Perspectives
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D'Andrea, Vito, Cascini, Valentina, Russo, Rosellina, Perri, Alessandro, Prontera, Giorgia, Ancora, Gina, Vento, Giovanni, Lisi, Gabriele, Barone, Giovanni, D’Andrea, Vito (ORCID:0000-0002-0980-799X), Vento, Giovanni (ORCID:0000-0002-8132-5127), D'Andrea, Vito, Cascini, Valentina, Russo, Rosellina, Perri, Alessandro, Prontera, Giorgia, Ancora, Gina, Vento, Giovanni, Lisi, Gabriele, Barone, Giovanni, D’Andrea, Vito (ORCID:0000-0002-0980-799X), and Vento, Giovanni (ORCID:0000-0002-8132-5127)
- Abstract
Chest and abdominal X-rays after the insertion of an epicutaneo-caval catheter in infants are the standard method of checking the tip location in many neonatal intensive care units. The role of ultrasound in the tip location of the epicutaneo-caval catheter in neonates has been the subject of many recent studies. This systematic review investigates the accuracy of epicutaneo-caval catheter tip location by comparing ultrasound and conventional radiology. We performed a systematic literature search in multiple databases. The selection of studies yielded nineteen articles. The systematic review and meta-analysis were performed according to PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analysis). The analyses showed that ultrasound is a better imaging technique for epicutaneo-caval catheter tip location in the neonatal intensive care unit than conventional radiology. By improving operator training and selecting a standardized echography protocol, ultrasound could become the gold standard for visualizing the epicutaneo-caval catheter tip in the neonatal intensive care unit. This would have some important benefits: (1) increased accuracy in tip location (2); a more rapid use of the central venous access (3); and a significant reduction in radiation exposure.
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- 2023
16. Magnetic Resonance Imaging of Primary Adult Brain Tumors: State of the Art and Future Perspectives
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Martucci, Matia, primary, Russo, Rosellina, additional, Schimperna, Francesco, additional, D’Apolito, Gabriella, additional, Panfili, Marco, additional, Grimaldi, Alessandro, additional, Perna, Alessandro, additional, Ferranti, Andrea Maurizio, additional, Varcasia, Giuseppe, additional, Giordano, Carolina, additional, and Gaudino, Simona, additional
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- 2023
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17. Real-Time Ultrasound Tip Location Reduces Malposition and Radiation Exposure during Epicutaneo-Caval Catheter Placement in Neonates
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D'Andrea, Vito, additional, Prontera, Giorgia, additional, Cota, Francesco, additional, Russo, Rosellina, additional, Barone, Giovanni, additional, and Vento, Giovanni, additional
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- 2023
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18. BIOM-36. A STUDY OF CLINICAL AND MOLECULAR PROGNOSTIC FACTORS FOR RESPONSE TO REGORAFENIB IN RECURRENT GLIOBLASTOMA
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Chiesa, Silvia, primary, Mangraviti, Antonella, additional, Martini, Maurizio, additional, Cenci, Tonia, additional, Mazzarella, Ciro, additional, Gaudino, Simona, additional, Bracci, Serena, additional, Martino, Antonella, additional, Della Pepa, Giuseppe M, additional, Offi, Martina, additional, Gessi, Marco, additional, Russo, Rosellina, additional, Martucci, Matia, additional, Bartoli, Francesco Beghella, additional, Bonaventura, Rina Di, additional, Larocca, Luigi M, additional, Lauretti, Liverana, additional, Olivi, Alessandro, additional, Pallini, Roberto, additional, Balducci, Mario, additional, and D'Alessandris, Quintino Giorgio, additional
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- 2022
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19. MR imaging of brain pilocytic astrocytoma: beyond the stereotype of benign astrocytoma
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Gaudino, Simona, Martucci, Matia, Russo, Rosellina, Visconti, Emiliano, Gangemi, Emma, D’Argento, Francesco, Verdolotti, Tommaso, Lauriola, Libero, and Colosimo, Cesare
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- 2017
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20. New onset of Susac syndrome after mRNA COVID-19 vaccine: a case report
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Bianco, Assunta, primary, Colò, Francesca, additional, Falso, Silvia, additional, Russo, Rosellina, additional, Carlà, Matteo Maria, additional, Minucci, Angelo, additional, Cadoni, Gabriella, additional, Lucchini, Matteo, additional, Cicia, Alessandra, additional, Calabresi, Paolo, additional, and Mirabella, Massimiliano, additional
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- 2022
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21. Advanced MR imaging in hemispheric low-grade gliomas before surgery; the indications and limits in the pediatric age
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Gaudino, Simona, Russo, Rosellina, Verdolotti, Tommaso, Caulo, Massimo, and Colosimo, Cesare
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- 2016
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22. New onset of Susac syndrome after mRNA COVID-19 vaccine: a case report
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Bianco, Assunta, Colò, Francesca, Falso, Silvia, Russo, Rosellina, Carlà, Matteo Maria, Minucci, Angelo, Cadoni, Gabriella, Lucchini, Matteo, Cicia, Alessandra, Calabresi, Paolo, Mirabella, Massimiliano, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Lucchini, Matteo (ORCID:0000-0002-0447-2297), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Bianco, Assunta, Colò, Francesca, Falso, Silvia, Russo, Rosellina, Carlà, Matteo Maria, Minucci, Angelo, Cadoni, Gabriella, Lucchini, Matteo, Cicia, Alessandra, Calabresi, Paolo, Mirabella, Massimiliano, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Lucchini, Matteo (ORCID:0000-0002-0447-2297), Calabresi, Paolo (ORCID:0000-0003-0326-5509), and Mirabella, Massimiliano (ORCID:0000-0002-7783-114X)
- Abstract
Susac syndrome (SuS) is a rare immune-mediated disorder, affecting microvessels in the brain, retina and inner ear, leading to central nervous system dysfunction, visual disturbances and sensorineural hearing loss. These events may occur simultaneously or in succession. Since its first description in 1979 by John Susac, about 400 cases have been described; however, SuS is probably underdiagnosed. SuS usually affects young adults between 20 and 40 years (female-to-male ratio of 3.5/1) [1, 2]. Occlusive microvascular endotheliopathy/basement membranopathy represents a disease hallmark, but the pathogenesis is still debated. Infections, diet or medications have been described as possible triggers of autoimmunity [1]. In 2006, a case of SuS after smallpox vaccination was reported. The COVID-19 pandemic has affected over 260 million people and different neurological disorders have been related to both Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and vaccination [3]. Six cases of SuS related to SARS-CoV-2 infection or vaccination have been described: two following SARS-CoV2 infection, one related to ChAdOx1 vaccine, and three after Coronavac vaccine [4]. Here we report the first case of SuS after BNT162b2 mRNA COVID-19 vaccine (Comirnaty®).
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- 2022
23. Regorafenib in Glioblastoma Recurrence: How to Deal With MR Imaging Treatments Changes
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Gaudino, Simona, Marziali, Giammaria, Giordano, Carolina, Gigli, Riccardo, Varcasia, Giuseppe, Magnani, Francesca, Chiesa, Silvia, Balducci, Mario, Costantini, Alessandro Maria, Della Pepa, Giuseppe Maria, Olivi, Alessandro, Russo, Rosellina, Colosimo, Cesare, Simona Gaudino (ORCID:0000-0003-1681-4343), Carolina Giordano, Riccardo Gigli, Giuseppe Varcasia, Francesca Magnani, Silvia Chiesa (ORCID:0000-0003-0168-3459), Mario Balducci (ORCID:0000-0003-0398-9726), Alessandro Maria Costantini, Giuseppe Maria Della Pepa (ORCID:0000-0001-8698-3359), Alessandro Olivi (ORCID:0000-0002-4489-7564), Rosellina Russo, Cesare Colosimo (ORCID:0000-0003-3800-3648), Gaudino, Simona, Marziali, Giammaria, Giordano, Carolina, Gigli, Riccardo, Varcasia, Giuseppe, Magnani, Francesca, Chiesa, Silvia, Balducci, Mario, Costantini, Alessandro Maria, Della Pepa, Giuseppe Maria, Olivi, Alessandro, Russo, Rosellina, Colosimo, Cesare, Simona Gaudino (ORCID:0000-0003-1681-4343), Carolina Giordano, Riccardo Gigli, Giuseppe Varcasia, Francesca Magnani, Silvia Chiesa (ORCID:0000-0003-0168-3459), Mario Balducci (ORCID:0000-0003-0398-9726), Alessandro Maria Costantini, Giuseppe Maria Della Pepa (ORCID:0000-0001-8698-3359), Alessandro Olivi (ORCID:0000-0002-4489-7564), Rosellina Russo, and Cesare Colosimo (ORCID:0000-0003-3800-3648)
- Abstract
The treatment of recurrent high-grade gliomas remains a major challenge of daily neuro-oncology practice, and imaging findings of new therapies may be challenging. Regorafenib is a multi-kinase inhibitor that has recently been introduced into clinical practice to treat recurrent glioblastoma, bringing with it a novel panel of MRI imaging findings. On the basis of the few data in the literature and on our personal experience, we have identified the main MRI changes during regorafenib therapy, and then, we defined two different patterns, trying to create a simple summary line of the main changes of pathological tissue during therapy. We named these patterns, respectively, pattern A (less frequent, similar to classical progression disease) and pattern B (more frequent, with decreased diffusivity and decrease contrast-enhancement). We have also reported MR changes concerning signal intensity on T1-weighted and T2-weighted images, SWI, and perfusion imaging, derived from the literature (small series or case reports) and from our clinical experience. The clinical implication of these imaging modifications remains to be defined, taking into account that we are still at the dawn in the evaluation of such imaging modifications
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- 2022
24. Neuro-Oncology Multidisciplinary Tumor Board: The Point of View of the Neuroradiologist
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Gaudino, Simona, Giordano, Carolina, Magnani, Francesca, Cottonaro, Simone, Infante, Amato, Sabatino, Giovanni, La Rocca Giuseppe Maria Della Pepa, Giuseppe, D'Alessandris, Quintino Giorgio, Pallini, Roberto, Olivi, Alessandro, Balducci, Mario, Chiesa, Silvia, Gessi, Marco, Guadalupi, Pamela, Russo, Rosellina, Schiarelli, Chiara, Ausili Cefaro, Luca, Di Lella, Giuseppe Maria, Colosimo, Cesare, Simona Gaudino (ORCID:0000-0003-1681-4343), Carolina Giordano, Francesca Magnani, Giovanni Sabatino (ORCID:0000-0002-4227-0434), Quintino Giorgio D'Alessandris (ORCID:0000-0002-2953-9291), Roberto Pallini (ORCID:0000-0002-4611-8827), Alessandro Olivi (ORCID:0000-0002-4489-7564), Mario Balducci (ORCID:0000-0003-0398-9726), Silvia Chiesa (ORCID:0000-0003-0168-3459), Marco Gessi, Rosellina Russo, Chiara Schiarelli, Luca Ausili Cefaro, Giuseppe Maria Di Lella (ORCID:0000-0002-5945-7860), Cesare Colosimo (ORCID:0000-0003-3800-3648), Gaudino, Simona, Giordano, Carolina, Magnani, Francesca, Cottonaro, Simone, Infante, Amato, Sabatino, Giovanni, La Rocca Giuseppe Maria Della Pepa, Giuseppe, D'Alessandris, Quintino Giorgio, Pallini, Roberto, Olivi, Alessandro, Balducci, Mario, Chiesa, Silvia, Gessi, Marco, Guadalupi, Pamela, Russo, Rosellina, Schiarelli, Chiara, Ausili Cefaro, Luca, Di Lella, Giuseppe Maria, Colosimo, Cesare, Simona Gaudino (ORCID:0000-0003-1681-4343), Carolina Giordano, Francesca Magnani, Giovanni Sabatino (ORCID:0000-0002-4227-0434), Quintino Giorgio D'Alessandris (ORCID:0000-0002-2953-9291), Roberto Pallini (ORCID:0000-0002-4611-8827), Alessandro Olivi (ORCID:0000-0002-4489-7564), Mario Balducci (ORCID:0000-0003-0398-9726), Silvia Chiesa (ORCID:0000-0003-0168-3459), Marco Gessi, Rosellina Russo, Chiara Schiarelli, Luca Ausili Cefaro, Giuseppe Maria Di Lella (ORCID:0000-0002-5945-7860), and Cesare Colosimo (ORCID:0000-0003-3800-3648)
- Abstract
Background: The multi-disciplinary tumor board (MTB) is essential to quality cancer care and currently recommended to offer the best personalized clinical approach, but little has been published regarding MTBs in neuro-oncology (nMTBs). The aim of the present paper is to describe our nMTB, to evaluate its impact on clinical management decisions, and to assess the role of neuroradiologists. Methods: The retrospective evaluation of the cases discussed at our nMTB from March 2017 to March 2020. From the electronic records, we extracted epidemiological, clinical and other specific data of nMTB. From the radiological records, we calculated data relating to the number, time for revision, and other specifications of MRI re-evaluation. Statistical analysis was performed. Results: a total of 447 discussions were analyzed, representing 342 patients. The requests for case evaluations came from radiation oncologists (58.8%) and neurosurgeons (40.5%), and were mainly addressed to the neuroradiologist (73.8%). The most frequent questions were about the treatment's changes (64.4%). The change in patient treatment was reported in 40.5% of cases, 76.8% of these were based on the neuroradiologic assessment. A total of 1514 MRI examinations were re-evaluated, employing approximately 67 h overall. The median of the MRI exams reviewed per patient was 3 (min-max 1-12). Conclusions: Our study supported that the multidisciplinary approach to patient care can be particularly effective in managing brain tumors. A review by an expert neuroradiologist impacts patient management in the context of nMTBs, but has costs in terms of the time and effort spent preparing for it.
- Published
- 2022
25. Regorafenib in Glioblastoma Recurrence: How to Deal With MR Imaging Treatments Changes
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Gaudino, Simona, primary, Marziali, Giammaria, additional, Giordano, Carolina, additional, Gigli, Riccardo, additional, Varcasia, Giuseppe, additional, Magnani, Francesca, additional, Chiesa, Silvia, additional, Balducci, Mario, additional, Costantini, Alessandro Maria, additional, Della Pepa, Giuseppe Maria, additional, Olivi, Alessandro, additional, Russo, Rosellina, additional, and Colosimo, Cesare, additional
- Published
- 2022
- Full Text
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26. Neuro-Oncology Multidisciplinary Tumor Board: The Point of View of the Neuroradiologist
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Gaudino, Simona, primary, Giordano, Carolina, additional, Magnani, Francesca, additional, Cottonaro, Simone, additional, Infante, Amato, additional, Sabatino, Giovanni, additional, La Rocca, Giuseppe, additional, Della Pepa, Giuseppe Maria, additional, D’Alessandris, Quintino Giorgio, additional, Pallini, Roberto, additional, Olivi, Alessandro, additional, Balducci, Mario, additional, Chiesa, Silvia, additional, Gessi, Marco, additional, Guadalupi, Pamela, additional, Russo, Rosellina, additional, Schiarelli, Chiara, additional, Ausili Cefaro, Luca, additional, Di Lella, Giuseppe Maria, additional, and Colosimo, Cesare, additional
- Published
- 2022
- Full Text
- View/download PDF
27. Fibrolamellar hepatocellular carcinoma with biliary tumor thrombus: an unreported association
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De Gaetano, Anna Maria, Nure, Erida, Grossi, Ugo, Frongillo, Francesco, Russo, Rosellina, Vecchio, Fabio Maria, Lirosi, Maria Carmen, Sganga, Gabriele, Felice, Carla, Bonomo, Lorenzo, and Agnes, Salvatore
- Published
- 2013
- Full Text
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28. MR imaging of brain pilocytic astrocytoma: beyond the stereotype of benign astrocytoma.
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Gaudino, Simona, Martucci, Matia, Russo, Rosellina, Visconti, Emiliano, Gangemi, Emma, D'Argento, Francesco, Verdolotti, Tommaso, Lauriola, Libero, Colosimo, Cesare, Gaudino, Simona (ORCID:0000-0003-1681-4343), Lauriola, Libero (ORCID:0000-0003-0481-5138), Colosimo, Cesare (ORCID:0000-0003-3800-3648), Gaudino, Simona, Martucci, Matia, Russo, Rosellina, Visconti, Emiliano, Gangemi, Emma, D'Argento, Francesco, Verdolotti, Tommaso, Lauriola, Libero, Colosimo, Cesare, Gaudino, Simona (ORCID:0000-0003-1681-4343), Lauriola, Libero (ORCID:0000-0003-0481-5138), and Colosimo, Cesare (ORCID:0000-0003-3800-3648)
- Abstract
BACKGROUND: Pilocytic astrocytoma (PA) is the most common pediatric brain glioma and is considered the prototype of benign circumscribed astrocytoma. Despite its low malignancy, the CT and MRI features of brain PA may resemble those of much more aggressive brain tumors. Misdiagnosis of PA is particularly easy when it demonstrates MR morphological and non-morphological findings that are inconsistent with its non-aggressive nature and that overlap with the features of more aggressive brain tumors. METHOD: Basing on the evidence that the variation in the histological, genetic, and metabolic "fingerprint" for brain PA is dependent on tumor location, and the hypothesis that tumor location is related to the broad spectrum of morphological and non-morphological MR imaging findings, the authors discuss the MR imaging appearance of brain PA using a location-based approach to underline the typical and less typical imaging features and the main differential diagnosis of brain PA. A brief summary of the main pathological and clinical features, the natural history, and the treatment of brain PA is also provided. RESULT: A combination of morphological and non-morphological MR imaging features and a site-based approach to differential diagnosis are required for a pre-operative diagnosis. The new "cutting-edge" MR imaging sequences have the potential to impact the ease and confidence of pediatric brain tumor interpretation and offer a more efficient diagnostic work-up. CONCLUSIONS: Although the typical imaging features of brain pilocytic astrocytoma make radiological diagnosis relatively easy, an atypical and more aggressive appearance can lead to misdiagnosis. Knowing the broad spectrum of imaging characteristics on conventional and advanced MR imaging is important for accurate pre-operative radiological diagnosis and correctly interpreting changes during follow-up.
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- 2016
29. MR imaging of brain pilocytic astrocytoma: beyond the stereotype of benign astrocytoma
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Gaudino, Simona, primary, Martucci, Matia, additional, Russo, Rosellina, additional, Visconti, Emiliano, additional, Gangemi, Emma, additional, D’Argento, Francesco, additional, Verdolotti, Tommaso, additional, Lauriola, Libero, additional, and Colosimo, Cesare, additional
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- 2016
- Full Text
- View/download PDF
30. Fibrolamellar hepatocellular carcinoma with biliary tumor thrombus: an unreported association.
- Author
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Gaetano, Anna, Nure, Erida, Grossi, Ugo, Frongillo, Francesco, Russo, Rosellina, Vecchio, Fabio, Lirosi, Maria, Sganga, Gabriele, Felice, Carla, Bonomo, Lorenzo, and Agnes, Salvatore
- Abstract
Fibrolamellar hepatocellular carcinoma (FHCC) is a rare malignant tumor of hepatocyte origin occurring earlier in life than typical hepatocellular carcinoma (HCC). We describe a distinctive case of FHCC with biliary tumor thrombus (BTT) in a 25-year-old Caucasian patient, pointing out the imaging features supported by histopathology. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
31. Real-Time Ultrasound Tip Location Reduces Malposition and Radiation Exposure during Umbilical Venous Catheter Placement in Neonates: A Retrospective, Observational Study.
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D'Andrea, Vito, Prontera, Giorgia, Cota, Francesco, Perri, Alessandro, Russo, Rosellina, Barone, Giovanni, and Vento, Giovanni
- Subjects
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CENTRAL venous catheters , *CATHETERIZATION , *RADIATION exposure , *NEONATAL intensive care units , *ULTRASONIC imaging , *NEONATAL sepsis , *NEWBORN infants - Abstract
The umbilical venous catheter is a vital access device in neonatal intensive care units for preterm and critically ill infants. Correct positioning is crucial, as malpositioning can lead to severe complications. According to international guidelines, the position of the umbilical venous catheter tip must be assessed in real time; traditionally, the catheter is visualized with a thoracoabdominal X-ray, but one of the most effective and safest methods is therefore real-time ultrasound.Introduction: This study compares real-time ultrasound and traditional X-ray methods for assessing umbilical venous catheter tip location in 461 cases. The rate of tip malposition was analyzed retrospectively. The secondary aim was to assess indwelling time of umbilical venous catheters and reasons of removal.Methods: Real-time ultrasound tip location, found to be more reliable and efficient, demonstrated a significantly lower incidence of primary malpositioning compared to X-ray assessments (9.6 vs. 75.9%). The study also highlighted the association of real-time ultrasound with reduced catheter manipulation, fewer radiographs, and higher indwelling times of umbilical venous catheter. The multiple logistic regression showed a high probability of the central safe position of the umbilical venous catheter tip using real-time ultrasound tip location (odds ratio 29.5, 95% confidence interval: 17.4–49.4).Results: The findings support the adoption of real-time ultrasound in clinical settings to enhance umbilical venous catheter placement accuracy and minimize associated risks. A minimal training investment is needed to attain the proficiency to visualize the umbilical venous catheters, offering a substantial advantage in terms of both cost-effectiveness for the procedure and enhanced patient safety. [ABSTRACT FROM AUTHOR]Conclusion: - Published
- 2024
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32. Real-Time Ultrasound Tip Location Reduces Malposition and Radiation Exposure during Epicutaneo-Caval Catheter Placement in Neonates.
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D'Andrea V, Prontera G, Cota F, Russo R, Barone G, and Vento G
- Subjects
- Humans, Infant, Newborn, Retrospective Studies, Female, Male, Ultrasonography, Interventional methods, Ultrasonography methods, Catheterization, Peripheral methods, Catheterization, Peripheral adverse effects, Radiography, Thoracic methods, Intensive Care Units, Neonatal, Radiation Exposure prevention & control, Catheterization, Central Venous methods, Catheterization, Central Venous adverse effects
- Abstract
Objective: Epicutaneo-caval catheters (ECCs) are essential for the care of sick infants who require long-term medical and nutritional management. The aim of this study was to investigate the use of real-time ultrasound as an alternative to X-rays to reduce the incidence of primary malpositions during catheter insertion., Study Design: Data on ECCs were retrospectively collected in a tertiary neonatal intensive care unit. Catheter were analyzed considering the tip location technique (standard chest-abdominal radiograph vs real-time ultrasound) RESULTS: A total of 248 ECCs were analyzed. Of these, 118 catheters had primary malposition (47.6%). The tip of 165 catheters was assessed using standard chest-abdominal X-rays and 107 (64.8%) were found to be in an inappropriate location. In the group of 83 catheters that were placed using real-time ultrasound for tip location, only 11 catheters (13.2%) had primary malposition. The rate of malposition among the two groups showed a statistically significant difference ( p < 0.001). Hypothetically, 300 chest X-rays could have been saved if real-time ultrasound had been used to locate the tip, reducing radiation exposure to infants., Conclusion: The use of a real-time ultrasound may be beneficial in reducing primary catheter malpositions compared with conventional radiography. In addition, secondary malpositions and catheter-related complications can be monitored over time., Key Points: · Conventional radiology cannot be considered the "gold standard" for ECC tip location.. · Ultrasound is more accurate and reduces insertion time reducing the rate of primary malposition.. · Ultrasound can be performed in real time and it is the best technique for ECC tip location in infants.., Competing Interests: None declared., (Thieme. All rights reserved.)
- Published
- 2024
- Full Text
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33. The Role of Ultrasound in Epicutaneo-Caval Catheter Insertion in Neonates: Systematic Review, Meta-Analysis and Future Perspectives.
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D'Andrea V, Cascini V, Russo R, Perri A, Prontera G, Ancora G, Vento G, Lisi G, and Barone G
- Abstract
Chest and abdominal X-rays after the insertion of an epicutaneo-caval catheter in infants are the standard method of checking the tip location in many neonatal intensive care units. The role of ultrasound in the tip location of the epicutaneo-caval catheter in neonates has been the subject of many recent studies. This systematic review investigates the accuracy of epicutaneo-caval catheter tip location by comparing ultrasound and conventional radiology. We performed a systematic literature search in multiple databases. The selection of studies yielded nineteen articles. The systematic review and meta-analysis were performed according to PRISMA (Preferred Reporting Items for Systematic reviews and Meta-analysis). The analyses showed that ultrasound is a better imaging technique for epicutaneo-caval catheter tip location in the neonatal intensive care unit than conventional radiology. By improving operator training and selecting a standardized echography protocol, ultrasound could become the gold standard for visualizing the epicutaneo-caval catheter tip in the neonatal intensive care unit. This would have some important benefits: (1) increased accuracy in tip location (2); a more rapid use of the central venous access (3); and a significant reduction in radiation exposure.
- Published
- 2023
- Full Text
- View/download PDF
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