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1. Quantum Brownian Motion in the Caldeira-Leggett Model with a Damped Environment

Author

Buxton, Lester, Russo, Marc-Thomas, Al-Khalili, Jim, and Rocco, Andrea

Subjects
Quantum Physics
Abstract

We model a quantum system coupled to an environment of damped harmonic oscillators by following the approach of Caldeira-Leggett and adopting the Caldirola-Kanai Lagrangian for the bath oscillators. In deriving the master equation of the quantum system of interest (a particle in a general potential), we show that the potential is modified non-trivially by a new inverted harmonic oscillator term, induced by the damping of the bath oscillators. We analyze numerically the case of a particle in a double-well potential, and find that this modification changes both the rate of decoherence at short times and the well-transfer probability at longer times. We also identify a simple rescaling condition that keeps the potential fixed despite changes in the environmental damping. Here, the increase of environmental damping leads to a slowing of decoherence.

Published
2023

2. The Neurostimulation Appropriateness Consensus Committee (NACC)®: Recommendations for the Mitigation of Complications of Neurostimulation

Author

Deer, Timothy R., Russo, Marc A., Sayed, Dawood, Pope, Jason E., Grider, Jay S., Hagedorn, Jonathan M., Falowski, Steven M., Al-Kaisy, Adnan, Slavin, Konstantin V., Li, Sean, Poree, Lawrence R., Eldabe, Sam, Meier, Kaare, Lamer, Tim J., Pilitsis, Julie G., De Andrés, Jose, Perruchoud, Christophe, Carayannopoulos, Alexios G., Moeschler, Susan M., Hadanny, Amir, Lee, Eric, Varshney, Vishal P., Desai, Mehul J., Pahapill, Peter, Osborn, J., Bojanic, Stana, Antony, Ajay, Piedimonte, Fabian, Hayek, Salim M., and Levy, Robert M.

Published
2024
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3. The Neurostimulation Appropriateness Consensus Committee (NACC)®: Recommendations for Spinal Cord Stimulation Long-Term Outcome Optimization and Salvage Therapy

Author

Deer, Timothy R., Russo, Marc, Grider, Jay S., Sayed, Dawood, Lamer, Tim J., Dickerson, David M., Hagedorn, Jonathan M., Petersen, Erika A., Fishman, Michael A., FitzGerald, James, Baranidharan, Ganesan, De Ridder, Dirk, Chakravarthy, Krishnan V., Al-Kaisy, Adnan, Hunter, Corey W., Buchser, Eric, Chapman, Kenneth, Gilligan, Chris, Hayek, Salim M., Thomson, Simon, Strand, Natalie, Jameson, Jessica, Simopoulos, Thomas T., Yang, Ajax, De Coster, Olivier, Cremaschi, Fabián, Christo, Paul J., Varshney, Vishal, Bojanic, Stana, and Levy, Robert M.

Published
2024
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4. Five-Year Longitudinal Follow-Up of Restorative Neurostimulation Shows Durability of Effectiveness in Patients With Refractory Chronic Low Back Pain Associated With Multifidus Muscle Dysfunction

Author

Gilligan, Christopher, Volschenk, Willem, Russo, Marc, Green, Matthew, Gilmore, Christopher, Mehta, Vivek, Deckers, Kristiaan, De Smedt, Kris, Latif, Usman, Sayed, Dawood, Georgius, Peter, Gentile, Jonathan, Mitchell, Bruce, Langhorst, Meredith, Huygen, Frank, Baranidharan, Ganesan, Patel, Vikas, Mironer, Eugene, Ross, Edgar, Carayannopoulos, Alexios, Hayek, Salim, Gulve, Ashish, Van Buyten, Jean-Pierre, Tohmeh, Antoine, Fischgrund, Jeffrey, Lad, Shivanand, Ahadian, Farshad, Deer, Timothy, Klemme, William, Rauck, Richard, Rathmell, James, Maislin, Greg, Heemels, Jan Pieter, and Eldabe, Sam

Published
2024
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7. ECAP-Controlled Closed-Loop Spinal Cord Stimulation Efficacy and Opioid Reduction Over 24-Months: Final Results of the Prospective, Multicenter, Open-Label Avalon Study.

Author

Brooker, Charles, Russo, Marc, Cousins, Michael, Taylor, Nathan, Holford, Lewis, Martin, Rebecca, Boesel, Tillman, Sullivan, Richard, Hanson, Erin, Gmel, Gerrit, Shariati, Nastaran, Poree, Lawrence, and Parker, John

Subjects
Chronic, closed-loop SCS, evoke, evoked compound action potential, feedback, opioid, pain, spinal cord stimulation, Analgesics, Opioid, Chronic Pain, Humans, Prospective Studies, Quality of Life, Spinal Cord, Spinal Cord Stimulation, Treatment Outcome
Abstract

INTRODUCTION: Chronic pain is a major public health concern, as is the associated use of opioid medications, highlighting the importance of alternative treatments, such as spinal cord stimulation (SCS). Here, we present the final 24-month results of the Avalon study, which investigated the use of the first closed-loop SCS system in patients with chronic pain. The system measures the evoked compound action potentials (ECAPs) elicited by each stimulus pulse and drives a feedback loop to maintain the ECAP amplitude near constant. METHODS: Fifty patients were implanted with the Evoke system (Saluda Medical) and followed over 24-months. Pain, quality of life (QOL), function, sleep, and medication use were collected at baseline and each scheduled visit. ECAP amplitudes and programming adjustments were also monitored. RESULTS: At 24 months, responder rates (≥ 50% pain reduction) and high responder rates (≥ 80% pain reduction) for overall pain were 89.5% and 68.4%, respectively, the latter up from 42.2% at 3 months. Significant improvements from baseline were observed in QOL, function, and sleep over the 24 months, including ≥ 80% experiencing a minimally important difference in QOL and > 50% experiencing a clinically significant improvement in sleep. At 24 months, 82.8% of patients with baseline opioid use eliminated or reduced their opioid intake. Over the course of the study, reprogramming need fell to an average of less than once a year. CONCLUSION: Over a 24-month period, the Evoke closed-loop SCS maintained its therapeutic efficacy despite a marked reduction in opioid use and steady decrease in the need for reprogramming.

Published
2021

10. Holistic Treatment Response: An International Expert Panel Definition and Criteria for a New Paradigm in the Assessment of Clinical Outcomes of Spinal Cord Stimulation

Author

Levy, Robert M., Mekhail, Nagy, Abd-Elsayed, Alaa, Abejón, David, Anitescu, Magdalena, Deer, Timothy R., Eldabe, Sam, Goudman, Lisa, Kallewaard, Jan W., Moens, Maarten, Petersen, Erika A., Pilitsis, Julie G., Pope, Jason E., Poree, Lawrence, Raslan, Ahmed M., Russo, Marc, Sayed, Dawood, Staats, Peter S., Taylor, Rod S., Thomson, Simon, Verrills, Paul, and Duarte, Rui V.

Published
2023
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12. Sustained Long-Term Outcomes With Closed-Loop Spinal Cord Stimulation: 12-Month Results of the Prospective, Multicenter, Open-Label Avalon Study.

Author

Russo, Marc, Brooker, Charles, Cousins, Michael, Taylor, Nathan, Boesel, Tillman, Sullivan, Richard, Holford, Lewis, Hanson, Erin, Gmel, Gerrit, Shariati, Nastaran, Poree, Lawrence, and Parker, John

Subjects
Action potentials, Back pain, Chronic pain, Electric stimulation, Feedback, Pain management, Spinal cord stimulation, Adult, Aged, Chronic Pain, Female, Humans, Male, Middle Aged, Pain Management, Pain Measurement, Prospective Studies, Quality of Life, Spinal Cord, Spinal Cord Stimulation, Time Factors, Treatment Outcome
Abstract

BACKGROUND: Spinal cord stimulation (SCS) activates the dorsal column fibers using electrical stimuli. Current SCS systems function in fixed-output mode, delivering the same stimulus regardless of spinal cord (SC) activation. OBJECTIVE: To present long-term outcomes of a novel closed-loop SCS system that aims to maintain the SC activation near a set target level and within a therapeutic window for each patient. SC activation is measured through the evoked compound action potential (ECAP) generated by each stimulus pulse. METHODS: Fifty patients with lower back and/or leg pain who were successfully trialed received a permanent system (Evoke; Saluda Medical, Sydney, Australia). Ratings of pain (visual analog scale), quality of life, function, sleep, and medication use were collected at baseline and at each visit. SC activation levels were reported in summary statistics. The therapeutic window for each individual patient was defined as the range of ECAP amplitudes between sensation threshold and uncomfortably strong stimulation. RESULTS: At 12 mo, the proportion of patients with ≥50% relief was 76.9% (back), 79.3% (leg), and 81.4% (overall), and the proportion with ≥80% pain relief was 56.4% (back), 58.6% (leg), and 53.5% (overall). Patients spent a median of 84.9% of their time with stimulation in their therapeutic window, and 68.8% (22/32) eliminated or reduced their opioid intake. Statistically significant improvements in secondary outcomes were observed. CONCLUSION: The majority of patients experienced more than 80% pain relief with stable SC activation, as measured by ECAP amplitude at 12 mo, providing evidence for the long-term effectiveness of the Evoke closed-loop SCS system.

Published
2020

15. Three-Year Durability of Restorative Neurostimulation Effectiveness in Patients With Chronic Low Back Pain and Multifidus Muscle Dysfunction

Author

Gilligan, Christopher, Volschenk, Willem, Russo, Marc, Green, Matthew, Gilmore, Christopher, Mehta, Vivek, Deckers, Kristiaan, De Smedt, Kris, Latif, Usman, Sayed, Dawood, Georgius, Peter, Gentile, Jonathan, Mitchell, Bruce, Langhorst, Meredith, Huygen, Frank, Baranidharan, Ganesan, Patel, Vikas, Mironer, Eugene, Ross, Edgar, Carayannopoulos, Alexios, Hayek, Salim, Gulve, Ashish, Van Buyten, Jean-Pierre, Tohmeh, Antoine, Fischgrund, Jeffrey, Lad, Shivanand, Ahadian, Farshad, Deer, Timothy, Klemme, William, Rauck, Richard, Rathmell, James, Schwab, Frank, Maislin, Greg, Heemels, Jan Pieter, and Eldabe, Sam

Published
2023
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16. Long-Term Outcomes of Restorative Neurostimulation in Patients With Refractory Chronic Low Back Pain Secondary to Multifidus Dysfunction: Two-Year Results of the ReActiv8-B Pivotal Trial

Author

Gilligan, Christopher, Volschenk, Willem, Russo, Marc, Green, Matthew, Gilmore, Christopher, Mehta, Vivek, Deckers, Kristiaan, De Smedt, Kris, Latif, Usman, Georgius, Peter, Gentile, Jonathan, Mitchell, Bruce, Langhorst, Meredith, Huygen, Frank, Baranidharan, Ganesan, Patel, Vikas, Mironer, Eugene, Ross, Edgar, Carayannopoulos, Alexios, Hayek, Salim, Gulve, Ashish, Van Buyten, Jean-Pierre, Tohmeh, Antoine, Fischgrund, Jeffrey, Lad, Shivanand, Ahadian, Farshad, Deer, Timothy, Klemme, William, Rauck, Richard, Rathmell, James, Maislin, Greg, Heemels, Jan Pieter, and Eldabe, Sam

Published
2023
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17. The Neurostimulation Appropriateness Consensus Committee (NACC): Recommendations on Best Practices for Cervical Neurostimulation

Author

Deer, Timothy R., Russo, Marc, Grider, Jay S., Pope, Jason, Hagedorn, Jonathan M., Weisbein, Jacqueline, Abd-Elsayed, Alaa, Benyamin, Ramsin, Raso, Louis J., Patel, Kiran V., Provenzano, David, Kim, Philip S., Amirdelfan, Kasra, Bolash, Robert, Steegers, Monique, Sullivan, Richard, Verrills, Paul, Carlson, Jon, Kapural, Leo, Diwan, Sudhir, Barolat, Giancarlo, Pahapill, Peter A., De Andres, Jose, Raslan, Ahmed M., Lopez, Jose A., Leong, Michael S., Attias, Miguel B., Teddy, Peter, Green, Alexander L., Dario, Alessandro, Piedimonte, Fabian, Chapman, Kenneth B., Tomycz, Nestor D., FitzGerald, James, Gatzinsky, Kliment, Varshney, Vishal, Gish, Brandon, Lindsey, Brad L., Buvanendran, Asokumar, Lamer, Tim J., Slavin, Konstantin V., and Levy, Robert M.

Published
2022
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18. The Neurostimulation Appropriateness Consensus Committee (NACC): Recommendations for Surgical Technique for Spinal Cord Stimulation

Author

Deer, Timothy R., Russo, Marc A., Grider, Jay S., Pope, Jason, Rigoard, Philippe, Hagedorn, Jonathan M., Naidu, Ramana, Patterson, Denis G., Wilson, Derron, Lubenow, Timothy R., Buvanendran, Asokumar, Sheth, Samir J., Abdallah, Rany, Knezevic, N. Nick, Schu, Stefan, Nijhuis, Harold, Mehta, Pankaj, Vallejo, Ricardo, Shah, Jay M., Harned, Michael E., Jassal, Navdeep, Gonzalez, Jose Manuel, Pittelkow, Thomas P., Patel, Shachi, Bojanic, Stana, Chapman, Kenneth, Strand, Natalie, Green, Alexander L., Pahapill, Peter, Dario, Alessandro, Piedimonte, Fabian, and Levy, Robert M.

Published
2022
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22. Pulsed Radiofrequency 2 Hz Preserves the Dorsal Root Ganglion Neuron Physiological Ca2+ Influx, Cytosolic ATP Level, Δψm, and pERK Compared to 4 Hz: An Insight on the Safety of Pulsed Radiofrequency in Pain Management [Letter]

Author

Russo,Marc and Russo,Marc

Abstract

Marc Russo Hunter Pain Specialists, Broadmeadow, NSW, AustraliaCorrespondence: Marc Russo, Hunter Pain Specialists, 91 Chatham Street, Broadmeadow, NSW, 2292, Australia, Tel +61 2 4985 1800, Fax +61 2 4940 0322, Email algoguy@gmail.com

Published
2024

26. EP127 / #260 QUEEN MARY UNIVERSITY LONDON POSTGRADUATE CERTIFICATION (PGCERT): AN ACCREDITATION IN NEUROMODULATION AND PAIN MANAGEMENT

Author

Bajaj, Gaurav, primary, Rigoard, Philippe, additional, Kallewaard, Jan-Willem, additional, Huygen, Frank, additional, Gulve, Ashish, additional, Baranidharan, Ganesan, additional, Eldabe, Sam, additional, Fitzgerald, James, additional, Nikolic, Serge, additional, Bojanic, Stana, additional, Ellamushi, Habib, additional, Doshi, Paresh, additional, Doshi, Preeti, additional, Ghai, Babita, additional, Russo, Marc, additional, Poree, Lawrence, additional, Abd-Elsayed, Alaa, additional, Hayek, Salim, additional, Raslan, Ahmed, additional, Gilligan, Christopher, additional, Patel, Kiran, additional, Poply, Kavita, additional, and Mehta, Vivek, additional

Published
2023
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32. New Therapy for Refractory Chronic Mechanical Low Back Pain—Restorative Neurostimulation to Activate the Lumbar Multifidus: One Year Results of a Prospective Multicenter Clinical Trial

Author

Deckers, Kristiaan, De Smedt, Kris, Mitchell, Bruce, Vivian, David, Russo, Marc, Georgius, Peter, Green, Matthew, Vieceli, John, Eldabe, Sam, Gulve, Ashish, van Buyten, Jean-Pierre, Smet, Iris, Mehta, Vivek, Ramaswamy, Shankar, Baranidharan, Ganesan, Sullivan, Richard, Gassin, Robert, Rathmell, James, and Gilligan, Chris

Published
2018
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38. The Polyanalgesic Consensus Conference (PACC): Recommendations for Trialing of Intrathecal Drug Delivery Infusion Therapy

Author

Deer, Timothy R., Hayek, Salim M., Pope, Jason E., Lamer, Tim J., Hamza, Maged, Grider, Jay S., Rosen, Steven M., Narouze, Samir, Perruchoud, Christophe, Thomson, Simon, Russo, Marc, Grigsby, Eric, Doleys, Daniel M., Jacobs, Marilyn S., Saulino, Michael, Christo, Paul, Kim, Philip, Huntoon, Elliot Marc, Krames, Elliot, and Mekhail, Nagy

Published
2017
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39. The Neurostimulation Appropriateness Consensus Committee (NACC) Recommendations for Infection Prevention and Management

Author

Deer, Timothy R., Provenzano, David A., Hanes, Michael, Pope, Jason E., Thomson, Simon J., Russo, Marc A., McJunkin, Tory, Saulino, Michael, Raso, Louis J., Lad, Shivanand P., Narouze, Samer, Falowski, Steven M., Levy, Robert M., Baranidharan, Ganesan, Golovac, Stanley, Demesmin, Didier, Witt, William O., Simpson, Brian, Krames, Elliot, and Mekhail, Nagy

Published
2017
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40. The Neurostimulation Appropriateness Consensus Committee (NACC): Recommendations on Bleeding and Coagulation Management in Neurostimulation Devices

Author

Deer, Timothy R., Narouze, Samer, Provenzano, David A., Pope, Jason E., Falowski, Steven M., Russo, Marc A., Benzon, Honorio, Slavin, Konstantin, Pilitsis, Julie G., Alo, Kenneth, Carlson, Jonathan D., McRoberts, Porter, Lad, Shivanand P., Arle, Jeffrey, Levy, Robert M., Simpson, Brian, and Mekhail, Nagy

Published
2017
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43. Long-Term Outcomes of Restorative Neurostimulation in Patients With Refractory Chronic Low Back Pain Secondary to Multifidus Dysfunction:Two-Year Results of the ReActiv8-B Pivotal Trial

Author

Gilligan, Christopher, Volschenk, Willem, Russo, Marc, Green, Matthew, Gilmore, Christopher, Mehta, Vivek, Deckers, Kristiaan, De Smedt, Kris, Latif, Usman, Georgius, Peter, Gentile, Jonathan, Mitchell, Bruce, Langhorst, Meredith, Huygen, Frank, Baranidharan, Ganesan, Patel, Vikas, Mironer, Eugene, Ross, Edgar, Carayannopoulos, Alexios, Hayek, Salim, Gulve, Ashish, Van Buyten, Jean Pierre, Tohmeh, Antoine, Fischgrund, Jeffrey, Lad, Shivanand, Ahadian, Farshad, Deer, Timothy, Klemme, William, Rauck, Richard, Rathmell, James, Maislin, Greg, Heemels, Jan Pieter, Eldabe, Sam, Gilligan, Christopher, Volschenk, Willem, Russo, Marc, Green, Matthew, Gilmore, Christopher, Mehta, Vivek, Deckers, Kristiaan, De Smedt, Kris, Latif, Usman, Georgius, Peter, Gentile, Jonathan, Mitchell, Bruce, Langhorst, Meredith, Huygen, Frank, Baranidharan, Ganesan, Patel, Vikas, Mironer, Eugene, Ross, Edgar, Carayannopoulos, Alexios, Hayek, Salim, Gulve, Ashish, Van Buyten, Jean Pierre, Tohmeh, Antoine, Fischgrund, Jeffrey, Lad, Shivanand, Ahadian, Farshad, Deer, Timothy, Klemme, William, Rauck, Richard, Rathmell, James, Maislin, Greg, Heemels, Jan Pieter, and Eldabe, Sam

Abstract

Background: Impaired neuromuscular control and degeneration of the multifidus muscle have been linked to the development of refractory chronic low back pain (CLBP). An implantable restorative-neurostimulator system can override the underlying multifidus inhibition by eliciting episodic, isolated contractions. The ReActiv8-B randomized, active-sham-controlled trial provided effectiveness and safety evidence for this system, and all participants received therapeutic stimulation from four months onward. Objective: This study aimed to evaluate the two-year effectiveness of this restorative neurostimulator in patients with disabling CLBP secondary to multifidus muscle dysfunction and no indications for spine surgery. Materials and Methods: Open-label follow-up of 204 participants implanted with a restorative neurostimulation system (ReActiv8, Mainstay Medical, Dublin, Ireland) was performed. Pain intensity (visual analog scale [VAS]), disability (Oswestry disability index [ODI]), quality-of-life (EQ-5D-5L), and opioid intake were assessed at baseline, six months, one year, and two years after activation. Results: At two years (n = 156), the proportion of participants with ≥50% CLBP relief was 71%, and 65% reported CLBP resolution (VAS ≤ 2.5 cm); 61% had a reduction in ODI of ≥20 points, 76% had improvements of ≥50% in VAS and/or ≥20 points in ODI, and 56% had these substantial improvements in both VAS and ODI. A total of 87% of participants had continued device use during the second year for a median of 43% of the maximum duration, and 60% (34 of 57) had voluntarily discontinued (39%) or reduced (21%) opioid intake. Conclusions: At two years, 76% of participants experienced substantial, clinically meaningful improvements in pain, disability, or both. These results provide evidence of long-term effectiveness and durability of restorative neurostimulation in patients with disabling CLBP, secondary to multifidus muscle dysfunction. Clinical Trial Registration: The study

Published
2023

48. Long-term safety of spinal cord stimulation systems in a prospective, global registry of patients with chronic pain

Author

Rauck, Richard L, primary, Loudermilk, Eric, additional, Thomson, Simon J, additional, Paz-Solis, Jose Francisco, additional, Bojrab, Louis, additional, Noles, John, additional, Vesper, Jan, additional, Atallah, Joseph, additional, Roth, Daniel, additional, Hegarty, Joseph, additional, Prud'Homme, Michel, additional, Phillips, Gregory M, additional, Smith, Stephen G, additional, Ibrahim, Mohab, additional, Willoughby, Channing D, additional, Obray, Jon B, additional, Gupta, Mayank, additional, Paez, Julio, additional, Berg, Anthony P, additional, Harrison, Nathan J, additional, Maino, Paolo, additional, Mambalam, Praveen, additional, McCarty, Matthew, additional, Towlerton, Glyn, additional, Love-Jones, Sarah, additional, Ahmed, Shakil, additional, Lee, Albert, additional, Shah, Binit, additional, Goor-Aryeh, Itay, additional, Russo, Marc A, additional, Varela, Nicolas, additional, Phelps, Jeffrey B, additional, Cid, José, additional, Fernandez, Tacson, additional, Pérez-Hernández, Concepción, additional, Keehn, Douglas, additional, Rosenow, Joshua M, additional, Haider, Nameer, additional, Parrent, Andrew G, additional, Lawrence, Melinda M, additional, Georgius, Peter, additional, Demartini, Laura, additional, Mendiola, Agustin, additional, Mehta, Vivek, additional, Thoma, Reinhard, additional, Israel, Atef F, additional, Carolis, Giuliano De, additional, Bhatia, Sanjay, additional, Green, Matthew, additional, Villarreal, Armando, additional, Crooks, Matthew T, additional, Gwinn, Ryder P, additional, Pilitsis, Julie G, additional, Sato, Hitoaki, additional, Vega, Sergio Maldonado, additional, Hillegass, M. Gabriel, additional, Carnes, Paul, additional, Scherer, Christian, additional, Brill, Silviu, additional, Yu, James, additional, Brennan, James J, additional, Gatzinsky, Kliment, additional, Navani, Annu, additional, Snook Jr, Lee T, additional, Bujedo, Borja Mugabure, additional, Andrés Ares, Javier De, additional, Murillo, Abel, additional, Trobridge, Andrew T, additional, Assil, Kamyar, additional, Shah, Jawad, additional, McLeod, Carroll, additional, Buwembo, Joseph, additional, Coster, Olivier De, additional, Miller, Nathan, additional, Sanapati, Mehendra, additional, Mikhael, Medhat, additional, Przkora, Rene, additional, Sukenaga, Norihiko, additional, Raso, Louis J, additional, Calodney, Aaron K, additional, Cáceres Jerez, Luz Elena, additional, Uchiyama, Takuya, additional, Kallewaard, Jan-Willem, additional, Chandler, Brett, additional, Piedimonte, Fabián, additional, Candido, Kenneth D, additional, Weaver, Tristan E, additional, Agari, Takashi, additional, Holthouse, David, additional, Woon, Rex, additional, Patel, Nileshkumar, additional, Lechleiter, Kristen, additional, and Jain, Roshini, additional

Published
2023
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