3,660 results on '"Russo, D."'
Search Results
2. MITO END-3: efficacy of avelumab immunotherapy according to molecular profiling in first-line endometrial cancer therapy
- Author
-
Pignata, S., Califano, D., Lorusso, D., Arenare, L., Bartoletti, M., De Giorgi, U., Andreetta, C., Pisano, C., Scambia, G., Lombardi, D., Farolfi, A., Cinieri, S., Passarelli, A., Salutari, V., De Angelis, C., Mignogna, C., Priolo, D., Capoluongo, E.D., Tamberi, S., Scaglione, G.L., Arcangeli, V., De Cecio, R., Scognamiglio, G., Greco, F., Spina, A., Turinetto, M., Russo, D., Carbone, V., Casartelli, C., Schettino, C., and Perrone, F.
- Published
- 2024
- Full Text
- View/download PDF
3. Bat diversity boosts ecosystem services: Evidence from pine processionary moth predation
- Author
-
Augusto, A.M., Raposeira, H., Horta, P., Mata, V.A., Aizpurua, O., Alberdi, A., Jones, G., Razgour, O., Santos, S.A.P., Russo, D., and Rebelo, H.
- Published
- 2024
- Full Text
- View/download PDF
4. A 3D rheological model for the Aegean Region: Mechanical layering and seismotectonic implications
- Author
-
Maggini, M., Russo, D., and Caputo, R.
- Published
- 2023
- Full Text
- View/download PDF
5. Formate/bicarbonate interconversion for safe hydrogen storage: A review
- Author
-
Calabrese, M., Russo, D., di Benedetto, A., Marotta, R., and Andreozzi, R.
- Published
- 2023
- Full Text
- View/download PDF
6. Alternative academic approaches for testing homologous recombination deficiency in ovarian cancer in the MITO16A/MaNGO-OV2 trial
- Author
-
Capoluongo, E.D., Pellegrino, B., Arenare, L., Califano, D., Scambia, G., Beltrame, L., Serra, V., Scaglione, G.L., Spina, A., Cecere, S.C., De Cecio, R., Normanno, N., Colombo, N., Lorusso, D., Russo, D., Nardelli, C., D’Incalci, M., Llop-Guevara, A., Pisano, C., Baldassarre, G., Mezzanzanica, D., Artioli, G., Setaro, M., Tasca, G., Roma, C., Campanini, N., Cinieri, S., Sergi, A., Musolino, A., Perrone, F., Chiodini, P., Marchini, S., and Pignata, S.
- Published
- 2022
- Full Text
- View/download PDF
7. Italian Real-Life Experience of Patients with Hereditary Transthyretin Amyloidosis Treated with Patisiran
- Author
-
Di Stefano V, Fava A, Gentile L, Guaraldi P, Leonardi L, Poli L, Tagliapietra M, Vastola M, Fanara S, Ferrero B, Giorgi M, Perfetto F, Russo M, and Russo D
- Subjects
hereditary transthyretin amyloidosis ,patisiran ,real-life ,case reports ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Vincenzo Di Stefano,1 Antonella Fava,2 Luca Gentile,3 Pietro Guaraldi,4 Luca Leonardi,5 Loris Poli,6 Matteo Tagliapietra,7 Michele Vastola,8,9 Salvatore Fanara,1 Bruno Ferrero,10 Mauro Giorgi,2 Federico Perfetto,8 Massimo Russo,3 Domitilla Russo11 1Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, Palermo, Italy; 2Division of Cardiology, Heart Vascular and Thoracic Department, Città della Salute e della Scienza (Molinette Hospital- University of Turin), Turin, Italy; 3Unit of Neurology and Neuromuscular Disease, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; 4IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 5Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome Sant’Andrea Hospital, Rome, Italy; 6Department of Neurology, ASST Spedali Civili, Brescia, Italy; 7Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy; 8Tuscan Regional Amyloidosis Centre, Careggi University Hospital, Florence, Italy; 9Neurosciences Department, Florence University, Rome, Italy; 10SC Neurology 2U, Department of Neuroscience “Rita Levi Montalcini”, Città della Salute e della Scienza (Molinette Hospital -University of Turin), Turin, Italy; 11Division of Cardiology, Department of Clinical and Molecular Medicine, St. Andrea Hospital, Sapienza University, Rome, ItalyCorrespondence: Vincenzo Di Stefano, Department of Biomedicine, Neuroscience and advanced Diagnostic (BIND), University of Palermo Palermo, Italy, Via del Vespro 143, Palermo, 90127, Italy, Tel +39 3285781786, Fax +390916552974, Email vincenzo19689@gmail.comAbstract: Hereditary transthyretin amyloidosis (ATTRv) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensorimotor nerves, heart, autonomic function and other organs. The actual scenario of pharmaceutical approaches for ATTRv amyloidosis includes five main groups: TTR stabilizers, TTR mRNA silencers, TTR fibril disruptors, inhibitor of TTR fibril seeding and gene therapy. Patisiran is a small, double-stranded interfering RNA encapsulated in a lipid nanoparticle, able to penetrate into hepatocytes, where it selectively targets TTR mRNA, reducing TTR production. We report and discuss 9 cases of different patients with ATTRv amyloidosis successfully managed with patisiran in the real clinical practice. Literature data, as well as the above presented case reports, show that this drug is effective and safe in improving both neurological and cardiovascular symptoms of ATTRv amyloidosis, and to maintain a good QoL, independently form the stage of the disease and the involved mutation. Recent studies correlated improved functional and biochemical outcomes with a regression of amyloid burden, especially at the cardiac level. Today, patisiran can be considered a valid therapeutic option for the management of patients with ATTRv amyloidosis and polyneuropathy and cardiovascular symptoms.Keywords: hereditary transthyretin amyloidosis, patisiran, real-life, case reports
- Published
- 2022
8. Wildfires, heatwaves and human disturbance threaten insular endemic bats
- Author
-
Ancillotto, L., Fichera, G., Pidinchedda, E., Veith, M., Kiefer, A., Mucedda, M., and Russo, D.
- Published
- 2021
- Full Text
- View/download PDF
9. Photon-Counting Technologies for Efficient High-Capacity Space-to-Ground Laser Communications§
- Author
-
Caplan, D. O., primary, Darling, Z. J., additional, Grein, M. E., additional, Guyton, M., additional, Russo, D., additional, Tyrrell, B., additional, and Wagner, A., additional
- Published
- 2024
- Full Text
- View/download PDF
10. A Call to Action by the Italian Mesotherapy Society on Scientific Research
- Author
-
Mammucari M, Paolucci T, Russo D, Maggiori E, Di Marzo R, Migliore A, Massafra U, Ronconi G, Ferrara PE, Gori F, Bifarini B, Brauneis S, Vellucci R, Mediati RD, Violo B, Natoli S, Pediliggieri C, Di Campli C, and Collina MC
- Subjects
mesotherapy ,intradermal therapy ,research plan ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Massimo Mammucari,1 Teresa Paolucci,2 Domenico Russo,3 Enrica Maggiori,1 Raffaele Di Marzo,4 Alberto Migliore,5 Umberto Massafra,5 Gianpaolo Ronconi,6 Paola Emilia Ferrara,6 Fabio Gori,7 Barbara Bifarini,7 Stefano Brauneis,8 Renato Vellucci,9 Rocco Domenico Mediati,9 Bartolomeo Violo,10 Silvia Natoli,11 Carmen Pediliggieri,12 Cristiana Di Campli,12 Maria Chiara Collina12 1Primary Care Unit, ASL RM 1, Rome, Italy; 2Unit of Physical Medicine and Rehabilitation, G. D’ Annunzio University of Chieti-Pescara, Department of Oral Medical Science and Biotechnology (DSMOB), Chieti, Italy; 3“San Marco” Hospice and Palliative Care, Latina, Italy; 4Member of the Italian Society of Mesotherapy, Rome, Italy; 5Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, Rome, Italy; 6Physical Medicine and Rehabilitation Unit, IRCCS, Catholic University of Sacred Heart, Rome, Italy; 7Section of Anaesthesia, Intensive Care, and Pain Medicine, University Hospital Santa Maria Della Misericordia, Perugia, Italy; 8Pain Centre “Enzo BorzomatI”, University Hospital of Rome “Policlinico Umberto I”, Rome, Italy; 9Anaesthesiology Department, University Hospital Careggi, Florence, Italy; 10Pain Therapy Unit, S. Spirito Nuovo Regina Margherita Hospital, Rome, Italy; 11Department of Clinical Science and Translational Medicine, Tor Vergata University, Rome, Italy; 12Department of Vascular Surgery, Limb Salvage and Diabetic Foot, IDI-IRCCS, Rome, ItalyCorrespondence: Massimo MammucariPrimary Care Unit, Local Health, ASL RM 1, Rome, 00165, ItalyTel +39-06-61560695 Email massimo.mammucari@libero.itAbstract: Mesotherapy (local intradermal therapy, LIT) is a technique used to slowly spread drugs in tissues underlying the site of injection to prolong the pharmacological effect with respect to intramuscular injection. Recommendations for proper medical use of this technique have been made for pain medicine and rehabilitation, chronic venous disease, sport medicine, musculoskeletal disorders, several dermatological conditions, skin ageing, and immune-prophylaxis. Although mesotherapy is considered a valid technique, unresolved questions remain, which should be answered to standardize methodology and dosing regimen as well as to define the right indications in clinical practice. New randomized controlled trials are needed to test single products (dose, frequency of administration, efficacy and safety). Even infiltration of substances for dermo-cosmetic purposes must be guided by safety and efficacy tests before being proposed by mesotherapy. In this article, we put forth a preclinical and clinical research plan and a health technology assessment as a call to action by doctors, researchers and scientific societies to aid national health authorities in considering mesotherapy for prevention, treatment and rehabilitation paths.Keywords: mesotherapy, intradermal therapy, research plan
- Published
- 2021
11. Stereotactic ablative radiotherapy in castration-resistant prostate cancer patients with oligoprogression during androgen receptor-targeted therapy
- Author
-
Ingrosso, G., Detti, B., Fodor, A., Caini, S., Borghesi, S., Triggiani, L., Trippa, F., Russo, D., Bruni, A., Francolini, G., Lancia, A., Marinelli, L., Di Muzio, N., Livi, L., Magrini, S. M., Maranzano, E., Musio, D., Aristei, C., and Valeriani, M.
- Published
- 2021
- Full Text
- View/download PDF
12. Intradermal Vaccination: A Potential Tool in the Battle Against the COVID-19 Pandemic?
- Author
-
Migliore A, Gigliucci G, Di Marzo R, Russo D, and Mammucari M
- Subjects
vaccination ,intradermal ,covid-19 ,dose sparing. ,Public aspects of medicine ,RA1-1270 - Abstract
Alberto Migliore,1 Gianfranco Gigliucci,1 Raffaele Di Marzo,2 Domenico Russo,3 Massimo Mammucari4 1Department of Internal Medicine, Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, Rome, Italy; 2Italian Society of Mesotherapy, Rome, Italy; 3“San Marco” Hospice and Palliative Care, Latina, Italy; 4Primary Care Unit ASL RM 1, Rome, ItalyCorrespondence: Alberto Migliore Email migliore.alberto60@gmail.comAbstract: This narrative review is the final output of an initiative of the SIM (Italian Society of Mesotherapy). A narrative review of scientific literature on the efficacy of fractional intradermal vaccination in comparison with full doses has been conducted for the following pathogens: influenza virus, rabies virus, poliovirus (PV), hepatitis B virus (HBV), hepatitis A virus (HAV), diphtheria-tetanus-pertussis bacterias (DTP), human papillomavirus (HPV), Japanese encephalitis virus (JE), meningococcus, varicella zoster virus (VZV) and yellow fever virus. The findings suggest that the use of the intradermal route represents a valid strategy in terms of efficacy and efficiency for influenza, rabies and HBV vaccines. Some systematic reviews on influenza vaccines suggest the absence of a substantial difference between immunogenicity induced by a fractional ID dose of up to 20% and the IM dose in healthy adults, elderly, immunocompromised patients and children. Clinical studies of remaining vaccines against other pathogens (HAV, DTP bacterias, JE, meningococcal disease, VZV, and yellow fever virus) are scarce, but promising. In the context of a COVID-19 vaccine shortage, countries should investigate if a fractional dosing scheme may help to save doses and achieve herd immunity quickly. SIM urges the scientific community and health authorities to investigate the potentiality of fractionate intradermal administration in anti-COVID-19 vaccination.Keywords: vaccination, intradermal, COVID-19, dose sparing
- Published
- 2021
13. Free-ranging livestock and a diverse landscape structure increase bat foraging in mountainous landscapes
- Author
-
Ancillotto, L., Festa, F., De Benedetta, F., Cosentino, F., Pejic, B., and Russo, D.
- Published
- 2021
- Full Text
- View/download PDF
14. PARP Inhibitors in Endometrial Cancer: Current Status and Perspectives
- Author
-
Musacchio L, Caruso G, Pisano C, Cecere SC, Di Napoli M, Attademo L, Tambaro R, Russo D, Califano D, Palaia I, Muzii L, Benedetti Panici P, and Pignata S
- Subjects
endometrial cancer ,parp inhibitors ,pten mutation ,p53 mutation ,homologous recombination deficiency ,immune checkpoint inhibitors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Lucia Musacchio,1 Giuseppe Caruso,1 Carmela Pisano,2 Sabrina Chiara Cecere,2 Marilena Di Napoli,2 Laura Attademo,2 Rosa Tambaro,2 Daniela Russo,3 Daniela Califano,3 Innocenza Palaia,1 Ludovico Muzii,1 Pierluigi Benedetti Panici,1 Sandro Pignata2 1Department of Maternal and Child Health and Urological Sciences, University “Sapienza”, Policlinico Umberto I, Rome, Italy; 2Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Naples, Italy; 3Functional Genomic Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Naples, ItalyCorrespondence: Sandro PignataDepartment of Urology and Gynecology, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Semmola, Naples 80131, ItalyTel +39 0815903409Fax +39 0815903861Email s.pignata@istitutotumori.na.itAbstract: Advanced, recurrent and metastatic endometrial cancer (EC) has a dismal prognosis due to poor response rates to conventional treatments. In the era of precision medicine, the improved understanding of cancer genetics and molecular biology has led to the development of targeted therapies, such as poly (ADP-ribose) polymerase (PARP) inhibitors. This class of drugs that inhibit PARP enzymes has been investigated in many different types of tumors and its use in the treatment of gynecological malignancies has rapidly increased over the past few years. Data from several clinical trials showed that PARP inhibitors have a beneficial role in cancers with a defect in the homologous DNA recombination system, regardless of the BRCA mutational status. Since EC frequently shows mutations in PTEN and TP53 genes, indirectly involved in the homologous DNA recombination pathway, several in vivo and in vitro studies investigated the efficacy of PARP inhibitors in EC, showing promising results. This review will discuss the use of PARP inhibitors in endometrial cancer, summarizing data from preclinical studies and providing an overview of the ongoing trials, with a special focus on the development of combined treatment strategies with PARP inhibitors and immune checkpoint inhibitors.Keywords: endometrial cancer, PARP inhibitors, PTEN mutation, P53 mutation, homologous recombination deficiency, immune checkpoint inhibitors
- Published
- 2020
15. The importance of ponds for the conservation of bats in urban landscapes
- Author
-
Ancillotto, L., Bosso, L., Salinas-Ramos, V.B., and Russo, D.
- Published
- 2019
- Full Text
- View/download PDF
16. IRIDE White Book, An Interdisciplinary Research Infrastructure based on Dual Electron linacs&lasers
- Author
-
Alesini, D., Alessandroni, M., Anania, M. P., Andreas, S., Angelone, M., Arcovito, A., Arnesano, F., Artioli, M., Avaldi, L., Babusci, D., Bacci, A., Balerna, A., Bartalucci, S., Bedogni, R., Bellaveglia, M., Bencivenga, F., Benfatto, M., Biedron, S., Bocci, V., Bolognesi, M., Bolognesi, P., Boni, R., Bonifacio, R., Boscolo, M., Boscherini, F., Bossi, F., Broggi, F., Buonomo, B., Calo', V., Catone, D., Capogni, M., Capone, M., Castellano, M., Castoldi, A., Catani, L., Cavoto, G., Cherubini, N., Chirico, G., Cestelli-Guidi, M., Chiadroni, E., Chiarella, V., Cianchi, A., Cianci, M., Cimino, R., Ciocci, F., Clozza, A., Collini, M., Colo', G., Compagno, A., Contini, G., Coreno, M., Cucini, R., Curceanu, C., Dabagov, S., Dainese, E., Davoli, I., Dattoli, G., De Caro, L., De Felice, P., Della Longa, S., Monache, G. Delle, De Spirito, M., Di Cicco, A., Di Donato, C., Di Gioacchino, D., Di Giovenale, D., Di Palma, E., Di Pirro, G., Dodaro, A., Doria, A., Dosselli, U., Drago, A., Escribano, R., Esposito, A., Faccini, R., Ferrari, A., Ferrario, M., Filabozzi, A., Filippetto, D., Fiori, F., Frasciello, O., Fulgentini, L., Gallerano, G. P., Gallo, A., Gambaccini, M., Gatti, C., Gatti, G., Gauzzi, P., Ghigo, A., Ghiringhelli, G., Giannessi, L., Giardina, G., Giannini, C., Giorgianni, F., Giovenale, E., Gizzi, L., Guaraldo, C., Guazzoni, C., Gunnella, R., Hatada, K., Ivashyn, S., Jegerlehner, F., Keeffe, P. O., Kluge, W., Kupsc, A., Iannone, M., Labate, L., Sandri, P. Levi, Lombardi, V., Londrillo, P., Loreti, S., Losacco, M., Lupi, S., Macchi, A., Magazu', S., Mandaglio, G., Marcelli, A., Margutti, G., Mariani, C., Mariani, P., Marzo, G., Masciovecchio, C., Masjuan, P., Mattioli, M., Mazzitelli, G., Merenkov, N. P., Michelato, P., Migliardo, F., Migliorati, M., Milardi, C., Milotti, E., Milton, S., Minicozzi, V., Mobilio, S., Morante, S., Moricciani, D., Mostacci, A., Muccifora, V., Murtas, F., Musumeci, P., Nguyen, F., Orecchini, A., Organtini, G., Ottaviani, P. L., Pace, E., Paci, M., Pagani, C., Pagnutti, S., Palmieri, V., Palumbo, L., Panaccione, G. C., Papadopoulos, C. F., Papi, M., Passera, M., Pasquini, L., Pedio, M., Perrone, A., Petralia, A., Petrillo, C., Petrillo, V., Pillon, M., Pierini, P., Pietropaolo, A., Polosa, A. D., Pompili, R., Portoles, J., Prosperi, T., Quaresima, C., Quintieri, L., Rau, J. V., Reconditi, M., Ricci, A., Ricci, R., Ricciardi, G., Ripiccini, E., Romeo, S., Ronsivalle, C., Rosato, N., Rosenzweig, J. B., Rossi, G., Rossi, A. A., Rossi, A. R., Rossi, F., Russo, D., Sabatucci, A., Sabia, E., Sacchetti, F., Salducco, S., Sannibale, F., Sarri, G., Scopigno, T., Serafini, L., Sertore, D., Shekhovtsova, O., Spassovsky, I., Spadaro, T., Spataro, B., Spinozzi, F., Stecchi, A., Stellato, F., Surrenti, V., Tenore, A., Torre, A., Trentadue, L., Turchini, S., Vaccarezza, C., Vacchi, A., Valente, P., Venanzoni, G., Vescovi, S., Villa, F., Zanotti, G., Zema, N., and Zobov, M.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Physics - Accelerator Physics - Abstract
This report describes the scientific aims and potentials as well as the preliminary technical design of IRIDE, an innovative tool for multi-disciplinary investigations in a wide field of scientific, technological and industrial applications. IRIDE will be a high intensity 'particle factory', based on a combination of a high duty cycle radio-frequency superconducting electron linac and of high energy lasers. Conceived to provide unique research possibilities for particle physics, for condensed matter physics, chemistry and material science, for structural biology and industrial applications, IRIDE will open completely new research possibilities and advance our knowledge in many branches of science and technology. IRIDE will contribute to open new avenues of discoveries and to address most important riddles: What does matter consist of? What is the structure of proteins that have a fundamental role in life processes? What can we learn from protein structure to improve the treatment of diseases and to design more efficient drugs? But also how does an electronic chip behave under the effect of radiations? How can the heat flow in a large heat exchanger be optimized? The scientific potential of IRIDE is far reaching and justifies the construction of such a large facility in Italy in synergy with the national research institutes and companies and in the framework of the European and international research. It will impact also on R&D work for ILC, FEL, and will be complementarity to other large scale accelerator projects. IRIDE is also intended to be realized in subsequent stages of development depending on the assigned priorities., Comment: 270 pages
- Published
- 2013
17. Geochemistry, luminescence and innovative dose rate determination of a Chalcolithic calcite-rich negative feature
- Author
-
Rodrigues, A.L., Dias, M.I., Valera, A.C., Rocha, F., Prudêncio, M.I., Marques, R., Cardoso, G., and Russo, D.
- Published
- 2019
- Full Text
- View/download PDF
18. Connection between slow and fast dynamics of molecular liquids around the glass transition
- Author
-
Niss, K., Dalle-Ferrier, C., Frick, B., Russo, D., Dyre, J., and Alba-Simionesco, C.
- Subjects
Condensed Matter - Soft Condensed Matter - Abstract
The mean-square displacement (MSD) was measured by neutron scattering at various temperatures and pressures for a number of molecular glass-forming liquids. The MSD is invariant along the glass-transition line at the pressure studied, thus establishing an ``intrinsic'' Lindemann criterion for any given liquid. A one-to-one connection between the MSD's temperature dependence and the liquid's fragility is found when the MSD is evaluated on a time scale of approximately 4 nanoseconds, but does not hold when the MSD is evaluated at shorter times. The findings are discussed in terms of the elastic model and the role of relaxations, and the correlations between slow and fast dynamics are addressed., Comment: accepted by Phys Rev E (2010)
- Published
- 2009
- Full Text
- View/download PDF
19. Evaluation of a rapid and sensitive RT-qPCR assay for the detection of Ebola Virus
- Author
-
Biava, M., Colavita, F., Marzorati, A., Russo, D., Pirola, D., Cocci, A., Petrocelli, A., Delli Guanti, M., Cataldi, G., Kamara, T.A., Kamara, A.S., Konneh, K., Cannas, A., Coen, S., Quartu, S., Meschi, S., Valli, M.B., Mazzarelli, A., Venditti, C., Grassi, G., Rozera, G., Castilletti, C., Mirazimi, A., Capobianchi, M.R., Ippolito, G., Miccio, R., and Di Caro, A.
- Published
- 2018
- Full Text
- View/download PDF
20. The role of protected areas in preserving habitat and functional connectivity for mobile flying vertebrates: the common noctule bat (Nyctalus noctula) in Tuscany (Italy) as a case study
- Author
-
Ducci, L., Roscioni, F., Carranza, M. L., Agnelli, P., Russo, D., Frate, L., Loy, A., Santini, G., and Di Febbraro, M.
- Published
- 2019
- Full Text
- View/download PDF
21. The Balkan long-eared bat (Plecotus kolombatovici) occurs in Italy - first confirmed record and potential distribution
- Author
-
Ancillotto, L., Mori, E., Bosso, L., Agnelli, P., and Russo, D.
- Published
- 2019
- Full Text
- View/download PDF
22. Lack of association between obesity and aggressiveness of differentiated thyroid cancer
- Author
-
Grani, G., Lamartina, L., Montesano, T., Ronga, G., Maggisano, V., Falcone, R., Ramundo, V., Giacomelli, L., Durante, C., Russo, D., and Maranghi, M.
- Published
- 2019
- Full Text
- View/download PDF
23. The relationship between uremic toxins and symptoms in older men and women with advanced chronic kidney disease
- Author
-
Massy Z. A., Chesnaye N. C., Larabi I. A., Dekker F. W., Evans M., Caskey F. J., Torino C., Porto G., Szymczak M., Drechsler C., Wanner C., Jager K. J., Alvarez J. C., Schneider A., Torp A., Iwig B., Perras B., Marx C., Blaser C., Emde C., Krieter D., Fuchs D., Irmler E., Platen E., Schmidt-Gurtler H., Schlee H., Naujoks H., Schlee I., Casar S., Beige J., Rothele J., Mazur J., Hahn K., Blouin K., Neumeier K., Anding-Rost K., Schramm L., Hopf M., Wuttke N., Frischmuth N., Ichtiaris P., Kirste P., Schulz P., Aign S., Biribauer S., Manan S., Roser S., Heidenreich S., Palm S., Schwedler S., Delrieux S., Renker S., Schattel S., Stephan T., Schmiedeke T., Weinreich T., Leimbach T., Stovesand T., Bahner U., Seeger W., Cupisti A., Sagliocca A., Ferraro A., Mele A., Naticchia A., Cosaro A., Ranghino A., Stucchi A., Pignataro A., De Blasio A., Pani A., Tsalouichos A., Bellasi A., Raffaele Di Iorio B., Butti A., Abaterusso C., Somma C., D'Alessandro C., Zullo C., Pozzi C., Bergamo D., Ciurlino D., Motta D., Russo D., Favaro E., Vigotti F., Ansali F., Conte F., Cianciotta F., Giacchino F., Cappellaio F., Pizzarelli F., Greco G., Bigatti G., Marinangeli G., Cabiddu G., Fumagalli G., Caloro G., Piccoli G., Capasso G., Gambaro G., Tognarelli G., Bonforte G., Conte G., Toscano G., Del Rosso G., Capizzi I., Baragetti I., Oldrizzi L., Gesualdo L., Biancone L., Magnano M., Ricardi M., Di Bari M., Laudato M., Luisa Sirico M., Ferraresi M., Provenzano M., Malaguti M., Palmieri N., Murrone P., Cirillo P., Dattolo P., Acampora P., Nigro R., Boero R., Scarpioni R., Sicoli R., Malandra R., Savoldi S., Bertoli S., Borrelli S., Maxia S., Maffei S., Mangano S., Cicchetti T., Rappa T., Palazzo V., De Simone W., Schrander A., Van Dam B., Siegert C., Gaillard C., Beerenhout C., Verburgh C., Janmaat C., Hoogeveen E., Hoorn E., Boots J., Boom H., Eijgenraam J. -W., Kooman J., Rotmans J., Vogt L., Raasveld M., Vervloet M., Van Buren M., Van Diepen M., Leurs P., Voskamp P., Blankestijn P., Van Esch S., Boorsma S., Berger S., Konings C., Aydin Z., Musiala A., Szymczak A., Olczyk E., Augustyniak-Bartosik H., Miskowiec-Wisniewska I., Manitius J., Pondel J., Jedrzejak K., Nowanska K., Nowak L., Durlik M., Dorota S., Nieszporek T., Heleniak Z., Jonsson A., Blom A. -L., Rogland B., Wallquist C., Vargas D., Dimeny E., Sundelin F., Uhlin F., Welander G., Bascaran Hernandez I., Grontoft K. -C., Stendahl M., Svensson M., Heimburger O., Kashioulis P., Melander S., Almquist T., Jensen U., Woodman A., McKeever A., Ullah A., McLaren B., Harron C., Barrett C., O'Toole C., Summersgill C., Geddes C., Glowski D., McGlynn D., Sands D., Roy G., Hirst G., King H., McNally H., Masri-Senghor H., Murtagh H., Rayner H., Turner J., Wilcox J., Berdeprado J., Wong J., Banda J., Jones K., Haydock L., Wilkinson L., Carmody M., Weetman M., Joinson M., Dutton M., Matthews M., Morgan N., Bleakley N., Cockwell P., Roderick P., Mason P., Kalra P., Sajith R., Chapman S., Navjee S., Crosbie S., Brown S., Tickle S., Mathavakkannan S., Kuan Y., Massy, Z. A., Chesnaye, N. C., Larabi, I. A., Dekker, F. W., Evans, M., Caskey, F. J., Torino, C., Porto, G., Szymczak, M., Drechsler, C., Wanner, C., Jager, K. J., Alvarez, J. C., Schneider, A., Torp, A., Iwig, B., Perras, B., Marx, C., Blaser, C., Emde, C., Krieter, D., Fuchs, D., Irmler, E., Platen, E., Schmidt-Gurtler, H., Schlee, H., Naujoks, H., Schlee, I., Casar, S., Beige, J., Rothele, J., Mazur, J., Hahn, K., Blouin, K., Neumeier, K., Anding-Rost, K., Schramm, L., Hopf, M., Wuttke, N., Frischmuth, N., Ichtiaris, P., Kirste, P., Schulz, P., Aign, S., Biribauer, S., Manan, S., Roser, S., Heidenreich, S., Palm, S., Schwedler, S., Delrieux, S., Renker, S., Schattel, S., Stephan, T., Schmiedeke, T., Weinreich, T., Leimbach, T., Stovesand, T., Bahner, U., Seeger, W., Cupisti, A., Sagliocca, A., Ferraro, A., Mele, A., Naticchia, A., Cosaro, A., Ranghino, A., Stucchi, A., Pignataro, A., De Blasio, A., Pani, A., Tsalouichos, A., Bellasi, A., Raffaele Di Iorio, B., Butti, A., Abaterusso, C., Somma, C., D'Alessandro, C., Zullo, C., Pozzi, C., Bergamo, D., Ciurlino, D., Motta, D., Russo, D., Favaro, E., Vigotti, F., Ansali, F., Conte, F., Cianciotta, F., Giacchino, F., Cappellaio, F., Pizzarelli, F., Greco, G., Bigatti, G., Marinangeli, G., Cabiddu, G., Fumagalli, G., Caloro, G., Piccoli, G., Capasso, G., Gambaro, G., Tognarelli, G., Bonforte, G., Conte, G., Toscano, G., Del Rosso, G., Capizzi, I., Baragetti, I., Oldrizzi, L., Gesualdo, L., Biancone, L., Magnano, M., Ricardi, M., Di Bari, M., Laudato, M., Luisa Sirico, M., Ferraresi, M., Provenzano, M., Malaguti, M., Palmieri, N., Murrone, P., Cirillo, P., Dattolo, P., Acampora, P., Nigro, R., Boero, R., Scarpioni, R., Sicoli, R., Malandra, R., Savoldi, S., Bertoli, S., Borrelli, S., Maxia, S., Maffei, S., Mangano, S., Cicchetti, T., Rappa, T., Palazzo, V., De Simone, W., Schrander, A., Van Dam, B., Siegert, C., Gaillard, C., Beerenhout, C., Verburgh, C., Janmaat, C., Hoogeveen, E., Hoorn, E., Boots, J., Boom, H., Eijgenraam, J. -W., Kooman, J., Rotmans, J., Vogt, L., Raasveld, M., Vervloet, M., Van Buren, M., Van Diepen, M., Leurs, P., Voskamp, P., Blankestijn, P., Van Esch, S., Boorsma, S., Berger, S., Konings, C., Aydin, Z., Musiala, A., Szymczak, A., Olczyk, E., Augustyniak-Bartosik, H., Miskowiec-Wisniewska, I., Manitius, J., Pondel, J., Jedrzejak, K., Nowanska, K., Nowak, L., Durlik, M., Dorota, S., Nieszporek, T., Heleniak, Z., Jonsson, A., Blom, A. -L., Rogland, B., Wallquist, C., Vargas, D., Dimeny, E., Sundelin, F., Uhlin, F., Welander, G., Bascaran Hernandez, I., Grontoft, K. -C., Stendahl, M., Svensson, M., Heimburger, O., Kashioulis, P., Melander, S., Almquist, T., Jensen, U., Woodman, A., Mckeever, A., Ullah, A., Mclaren, B., Harron, C., Barrett, C., O'Toole, C., Summersgill, C., Geddes, C., Glowski, D., Mcglynn, D., Sands, D., Roy, G., Hirst, G., King, H., Mcnally, H., Masri-Senghor, H., Murtagh, H., Rayner, H., Turner, J., Wilcox, J., Berdeprado, J., Wong, J., Banda, J., Jones, K., Haydock, L., Wilkinson, L., Carmody, M., Weetman, M., Joinson, M., Dutton, M., Matthews, M., Morgan, N., Bleakley, N., Cockwell, P., Roderick, P., Mason, P., Kalra, P., Sajith, R., Chapman, S., Navjee, S., Crosbie, S., Brown, S., Tickle, S., Mathavakkannan, S., Kuan, Y., Nephrology, ACS - Diabetes & metabolism, Medical Informatics, APH - Methodology, APH - Aging & Later Life, APH - Quality of Care, APH - Global Health, APH - Health Behaviors & Chronic Diseases, and ACS - Pulmonary hypertension & thrombosis
- Subjects
Transplantation ,Nephrology ,uremic toxins ,CKD ,symptoms ,symptom ,elderly - Abstract
Background Patients with stage 4/5 chronic kidney disease (CKD) suffer from various symptoms. The retention of uremic solutes is thought to be associated with those symptoms. However, there are relatively few rigorous studies on the potential links between uremic toxins and symptoms in patients with CKD. Methods The EQUAL study is an ongoing observational cohort study of non-dialyzed patients with stage 4/5 CKD. EQUAL patients from Germany, Poland, Sweden and the UK were included in the present study (n = 795). Data and symptom self-report questionnaires were collected between April 2012 and September 2020. Baseline uric acid and parathyroid hormone and 10 uremic toxins were quantified. We tested the association between uremic toxins and symptoms and adjusted P-values for multiple testing. Results Symptoms were more frequent in women than in men with stage 4/5 CKD, while levels of various uremic toxins were higher in men. Only trimethylamine N-oxide (TMAO; positive association with fatigue), p-cresyl sulfate (PCS) with constipation and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (negative association with shortness of breath) demonstrated moderately strong associations with symptoms in adjusted analyses. The association of phenylacetylglutamine with shortness of breath was consistent in both sexes, although it only reached statistical significance in the full population. In contrast, TMAO (fatigue) and PCS and phenylacetylglutamine (constipation) were only associated with symptoms in men, who presented higher serum levels than women. Conclusion Only a limited number of toxins were associated with symptoms in persons with stage 4/5 CKD. Other uremic toxins, uremia-related factors or psychosocial factors not yet explored might contribute to symptom burden.
- Published
- 2022
24. Environmental drivers of parasite load and species richness in introduced parakeets in an urban landscape
- Author
-
Ancillotto, L., Studer, V., Howard, T., Smith, V. S., McAlister, E., Beccaloni, J., Manzia, F., Renzopaoli, F., Bosso, L., Russo, D., and Mori, E.
- Published
- 2018
- Full Text
- View/download PDF
25. Water-soluble chlorophyll-binding proteins from Brassica oleracea allow for stable photobiocatalytic oxidation of cellulose by a lytic polysaccharide monooxygenase
- Author
-
Dodge, N., Russo, D. A., Blossom, B. M., Singh, R. K., van Oort, B., Croce, R., Bjerrum, M. J., and Jensen, P. E.
- Published
- 2020
- Full Text
- View/download PDF
26. dsDNA from extracellular vesicles (EVs) in adult AML
- Author
-
Bernardi, Simona, Zanaglio, C., Farina, M., Polverelli, N., Malagola, M., and Russo, D.
- Published
- 2021
- Full Text
- View/download PDF
27. Evaluation of the effectiveness and efficiency of the triage emergency department nursing protocol for the management of pain
- Author
-
Butti L, Bierti O, Lanfrit R, Bertolini R, Chittaro S, Delli Compagni S, Del Russo D, Mancusi RL, and Pertoldi F
- Subjects
pain management ,protocol ,triage ,analgesic ,orosoluble paracetamol ,Medicine (General) ,R5-920 - Abstract
Loris Butti,1 Olga Bierti,1 Raffaela Lanfrit,1 Romina Bertolini,1 Sara Chittaro,1 Stefania Delli Compagni,1 Davide Del Russo,1 Rossella Letizia Mancusi,2 Franco Pertoldi1 1S.O.C. Emergency Medicine, AAS3 Ospedale Sant’Antonio di San Daniele del Friuli, 2C.R.E.A. Sanità, University of Tor Vergata, Rome, Italy Introduction: Pain is a common symptom presented in the emergency department (ED) although it is often underestimated, poorly evaluated and treated. The application of a protocol for timely pain management ensured by the nurse can avoid the delays in the analgesic treatment and improve the patient’s quality of waiting.Aims: To check the effectiveness and efficiency of the protocol aimed at early pain management in triage, active in our ED. In particular, the response to analgesic treatment was evaluated 60 minutes after the administration and at discharge. Patient satisfaction was also evaluated using two anonymous questionnaires both at discharge and 48 hours later via telephone.Methods: A single-center, observational study was conducted on a prospective cohort of patients (aged ≥4 years) with a pain symptom at admission in ED with no surgical picture.Results: In the observation period (June 2015–May 2016), 382 patients were enrolled, and of these, 312 (84.8%) accepted pain therapy during triage stage in the ED. In 97.4% of the cases, orosoluble paracetamol 1000 mg was administered. In the re-evaluation done 60 minutes later, 65.9% of the patients showed a reduction of at least 2 points on Numeric Rating Scale (NRS), equal to a mean reduction of 2.24 points (95% CI: 2.03–2.45). The mean time of analgesia intake was equal to 5.9 minutes (95% CI: 3.8–8.1). In the re-evaluation done at discharge, 33.2% of the patients showed a reduction of NRS score >50%, leading to a mean reduction of 39% (95% CI: 35.3%−41.9%). The level of patient satisfaction was high with a mean value >9 points (maximum satisfaction =10).Conclusion: This protocol shows that optimal pain management was achieved by patients rapidly receiving an effective painkiller therapy at triage, leading to substantial patient satisfaction. In moderate pain, orosoluble paracetamol 1000 mg provided a reduction of NRS score by 2 points in 67.6% of the patients, confirming to be the analgesic of choice in ED. Keywords: pain management, protocol, triage, analgesic, orosoluble paracetamol
- Published
- 2017
28. Liposomal doxorubicin supercharge‐containing frontline treatment for diffuse large B‐cell lymphoma or classical Hodgkin lymphoma: preliminary results of a phase II study
- Author
-
Giordano, C., primary, Picardi, M., additional, Pugliese, N., additional, Della Pepa, R., additional, D'Ambrosio, A., additional, Muriano, F., additional, Rascato, M. G., additional, Esposito, M., additional, Fatigati, C., additional, Esposito, R., additional, Russo, D., additional, Vigliar, E., additional, Tocchetti, C., additional, Fonti, R., additional, Prastaro, M., additional, Del Vecchio, S., additional, Esposito, G., additional, Mainolfi, C., additional, Mascolo, M., additional, Troncone, G., additional, and Pane, F., additional
- Published
- 2023
- Full Text
- View/download PDF
29. MO-0051 SBRT in oligometastatic uterine cancer: a large, multicenter, retrospective study.
- Author
-
Macchia, G., primary, Pezzulla, D., additional, Campitelli, M., additional, Laliscia, C., additional, Fodor, A., additional, Bonome, P., additional, Draghini, L., additional, Ippolito, E., additional, De Sanctis, V., additional, Ferioli, M., additional, Titone, F., additional, Balcet, V., additional, Di Cataldo, V., additional, Russo, D., additional, Vicenzi, L., additional, Cossa, S., additional, Lucci, S., additional, Deodato, F., additional, Gambacorta, M.A., additional, and Ferrandina, G., additional
- Published
- 2023
- Full Text
- View/download PDF
30. PO-2184 Brachytherapy In The Elderly For Non-Melanoma Skin Carcers:A Single Center Experience
- Author
-
SANTO, B., primary, Barba, M.C., additional, Cavalera, E., additional, Ciurlia, E., additional, De Franco, P., additional, Di Paola, G., additional, De Matteis, S., additional, Federico, C., additional, Leone, A., additional, Papapleo, A., additional, and Russo, D., additional
- Published
- 2023
- Full Text
- View/download PDF
31. MO-0049 SBRT in ovary cancer patients progressing within PARP-Inhibitor maintenance regimen:Epimetheo study
- Author
-
Macchia, G., primary, Campitelli, M., additional, Russo, D., additional, Pezzulla, D., additional, Lucci, S., additional, Nardangeli, A., additional, Di Stefano, A., additional, Ronzino, G., additional, Federico, C., additional, Fagotti, A., additional, Russo, S.A., additional, Salutari, V., additional, Gambacorta, A., additional, Scambia, G., additional, and Ferrandina, G., additional
- Published
- 2023
- Full Text
- View/download PDF
32. Seismic imaging of fluid-filled inherited structures of the Northern Thessaly (Greece) seismic gap
- Author
-
Napolitano, F., primary, Amoroso, O., additional, De Novellis, V., additional, Adinolfi, G. M., additional, De Matteis, R., additional, Sansosti, E., additional, Russo, D., additional, Caputo, R., additional, and Convertito, V., additional
- Published
- 2023
- Full Text
- View/download PDF
33. Is TRIZ an Ecodesign Method?
- Author
-
Russo, D., Serafini, M., Rizzi, C., Howlett, Robert J., Series editor, Jain, Lakhmi C., Series editor, Setchi, Rossi, editor, Liu, Ying, editor, and Theobald, Peter, editor
- Published
- 2016
- Full Text
- View/download PDF
34. Homogeneous photo-Fenton processes at near neutral pH: A review
- Author
-
Clarizia, L., Russo, D., Di Somma, I., Marotta, R., and Andreozzi, R.
- Published
- 2017
- Full Text
- View/download PDF
35. Development and validation of a liquid chromatography–mass spectrometric assay for simultaneous determination of tacrolimus and 13-O-desmethyl tacrolimus in rat kidney tissue
- Author
-
Kirresh, Tatian, Tuteja, Sony, Russo, D., Brophy, P.D., and Murry, D.J.
- Published
- 2017
- Full Text
- View/download PDF
36. Removal of benzoylecgonine from water matrices through UV254/H2O2 process: Reaction kinetic modeling, ecotoxicity and genotoxicity assessment
- Author
-
Spasiano, D., Russo, D., Vaccaro, M., Siciliano, A., Marotta, R., Guida, M., Reis, N.M., Li Puma, G., and Andreozzi, R.
- Published
- 2016
- Full Text
- View/download PDF
37. Alternative academic approaches for testing homologous recombination deficiency in ovarian cancer in the MITO16A/MaNGO-OV2 trial
- Author
-
Capoluongo ED, B, Pellegrino, Arenare L, Califano D, Scambia G, L, Beltrame, V, Serra, Scaglione GL, Spina A, Cecere SC, De Cecio R, N, Normanno, N, Colombo, Lorusso D, Russo D, Nardelli C, M, D'Incalci, Llop-Guevara A, Pisano C, G, Baldassarre, Mezzanzanica D, Artioli G, Setaro M, Tasca G, C, Roma, Campanini N, Cinieri S, A, Sergi, Musolino A, Perrone F, Chiodini P, S, Marchini, Pignata S, Institut Català de la Salut, [Capoluongo ED] Department of Molecular Medicine and Medical Biotechnology, Università degli Studi di Napoli Federico II, Naples, Italy. Azienda Ospedaliera per L'Emergenza, Cannizzaro, Catania, Italy. [Pellegrino B] Department of Medicine and Surgery, University of Parma, Parma, Italy. Medical Oncology and Breast Unit, University Hospital of Parma, Parma, Italy. Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC), Parma, Italy. [Arenare L] Clinical Trial Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Naples, Italy. [Califano D] Microenvironment Molecular Targets Unit, Istituto Nazionale Tumori IRCCS – Fondazione G. Pascale, Naples, Italy. [Scambia G] Department of Women and Child Health, Division of Gynecologic Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. Department of Life Science and Public Health, Catholic University of Sacred Heart Largo Agostino Gemelli, Rome, Italy. [Beltrame L] Molecular Pharmacology laboratory, Group of Cancer Pharmacology IRCCS Humanitas Research Hospital, Rozzano, Italy. [Serra V, Guevara A] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Capoluongo, E, Pellegrino, B, Arenare, L, Califano, D, Scambia, G, Beltrame, L, Serra, V, Scaglione, G, Spina, A, Cecere, S, De Cecio, R, Normanno, N, Colombo, N, Lorusso, D, Russo, D, Nardelli, C, D'Incalci, M, Llop-Guevara, A, Pisano, C, Baldassarre, G, Mezzanzanica, D, Artioli, G, Setaro, M, Tasca, G, Roma, C, Campanini, N, Cinieri, S, Sergi, A, Musolino, A, Perrone, F, Chiodini, P, Marchini, S, Pignata, S, Capoluongo, E D, Scaglione, G L, and Cecere, S C
- Subjects
Cancer Research ,Paclitaxel ,Genetic Phenomena::Recombination, Genetic::Homologous Recombination [PHENOMENA AND PROCESSES] ,Ovaris - Càncer - Aspectes genètics ,neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas [ENFERMEDADES] ,Carboplatin ,Other subheadings::Other subheadings::/genetics [Other subheadings] ,Humans ,Homologous Recombination ,Recombinació genètica ,Platinum ,fenómenos genéticos::recombinación genética::recombinación homóloga [FENÓMENOS Y PROCESOS] ,Ovarian Neoplasms ,Mangifera ,molecular testing ,Otros calificadores::Otros calificadores::/genética [Otros calificadores] ,Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms [DISEASES] ,RD ,HRR ,Myriad ,ovarian cancer ,Ovaris - Càncer - Tractament ,Bevacizumab ,Oncology ,HRD ,Female ,Poly(ADP-ribose) Polymerases - Abstract
Molecular testing; Ovarian cancer Proves moleculars; Càncer d'ovaris Pruebas moleculares; Cáncer de ovarios Background The detection of homologous recombination deficiency (HRD) can identify patients who are more responsive to platinum and poly ADP ribose polymerase inhibitors (PARPi). MyChoice CDx (Myriad) is the most used HRD test in ovarian cancer (OC). However, some limitations of commercial tests exist, because of the high rate of inconclusive results, costs, and the impossibility of evaluating functional resistance mechanisms. Patients and methods Two academic genomic tests and a functional assay, the RAD51 foci, were evaluated to detect HRD. One hundred patients with high-grade OC enrolled in the MITO16A/MaNGO-OV2 trial and treated with first-line therapy with carboplatin, paclitaxel, and bevacizumab were analyzed. Results The failure rate of the two genomic assays was 2%. The sensitivity in detecting HRD when compared with Myriad was 98.1% and 90.6%, respectively. The agreement rate with Myriad was 0.92 and 0.87, with a Cohen’s κ coefficient corresponding to 0.84 and 0.74, respectively. For the RAD51 foci assay, the failure rate was 30%. When the test was successful, discordant results for deficient and proficient tumors were observed, and additional HRD patients were identified compared to Myriad; sensitivity was 82.9%, agreement rate was 0.65, and Cohen’s κ coefficient was 0.18. The HRD detected by genomic assays and residual tumor at primary surgery and stage was correlated with progression-free survival at multivariate analysis. Conclusions Results suggest the feasibility of academic tests for assessing HRD status that show robust concordance with Myriad and correlation with clinical outcome. The contribution of the functional information related to the RAD51 foci test to the genomic data needs further investigation. This work was supported by funding from the AIRC [grant numbers IG 2016 – ID. 18921 and IG 2021 – ID. 25932 projects – P.I. SP and CO-2018-12367051 (Ministero della Salute) P.I SP]; Ricerca Corrente grant M2/7 from Ministero della Salute to DC, Ricerca Corrente from Ministero della Salute to SP. SM is supported by the Italian Association for Cancer Research [grant number IG-2017 n: IG19997]. MITO16A/MaNGO-OV2 trial was partially supported by Roche. AL is a recipient of a grant from the Asociación Española contra el Cáncer (AECC) [grant number INVES20095LLOP]. VS is a recipient of a grant from the Instituto de Salud Carlos III [grant number CPII19/00033] and a European grant for personalized medicine [grant number ERAPERMED 2019-215]. BP is a recipient of a grant from GOIRC. BP was supported by ESMO with a Clinical Translational Fellowship aid supported by Roche. Any views, opinions, findings, conclusions, or recommendations expressed in this material are those solely of the authors and do not necessarily reflect those of ESMO or Roche. NC has received funding from AstraZeneca (to the institution). FP has received funding from Roche, AstraZeneca, Pfizer, Merck Sharp & Dome, Bayer, Incyte, Taiho Oncology, Janssen Cilag, Exelixis, Aileron, and Daiichi Sankyo (grants to the institution for clinical trial activities).
- Published
- 2022
38. A Case Study on the Productivity of Forwarder Extraction in Small-Scale Southern Italian Forests
- Author
-
Proto, A. R., Macrì, G., Visser, R., Harrill, H., Russo, D., and Zimbalatti, G.
- Published
- 2018
- Full Text
- View/download PDF
39. Acoustic evaluation of wood quality with a non-destructive method in standing trees: a first survey in Italy
- Author
-
Proto AR, Macrì G, Bernardini V, Russo D, and Zimbalatti G
- Subjects
Modulus of Elasticity ,Wood Density ,Thinning ,Calabrian Pine ,Forestry ,SD1-669.5 - Abstract
Research and development efforts are currently underway worldwide to examine the potential use of a wide range of non-destructive technologies (NDT) for evaluating wood and wood-based materials, from the assessment of standing trees to in-place structures. For this purpose, acoustic velocity by the Fakopp time of flight (TOF) tool was used to estimate the influence of four thinning treatments performed in Southern Italy. The objective of the study was to determine if the effects of silvicultural practices on wood quality can be identified using acoustic measurement to assess the MOEd of standing trees with non-destructive method in Calabrian pine (Pinus nigra Arnold subsp. calabrica). Four hundred and fifty standing trees from four sites were non-destructively tested using a time-of-flight acoustic wave technique. The thinning trials were conducted on 60-year-old plantations of Calabrian pine in four plots under different treatments: Control (T), light thinning (A), intermediate thinning (B) and heavy thinning (C). Statistical analysis demonstrated significant stress wave time differences between the stands with moderate thinning (A and B) and those with heavy thinning (C). The results showed that tree diameter has significant influence on acoustic wave measurements and a valid relationship exists between diameter at breast height and tree velocity. The results of these studies proved that the stress wave technique can be successfully applied on standing trees.
- Published
- 2017
- Full Text
- View/download PDF
40. Sudden cardiac death and chronic kidney disease: From pathophysiology to treatment strategies
- Author
-
Di Lullo, L., Rivera, R., Barbera, V., Bellasi, A., Cozzolino, M., Russo, D., De Pascalis, A., Banerjee, D., Floccari, F., and Ronco, C.
- Published
- 2016
- Full Text
- View/download PDF
41. Changes in the hydraulic properties of a clay soil under long-term irrigation with treated wastewater
- Author
-
Bardhan, G., Russo, D., Goldstein, D., and Levy, G.J.
- Published
- 2016
- Full Text
- View/download PDF
42. Privacy by design in systems for assisted living, personalised care, and wellbeing: A stakeholder analysis
- Author
-
Carboni A., Russo D., Moroni D., and Barsocchi P.
- Subjects
AHA ,Privacy by design ,IS ,AAL ,Biomedical Engineering ,Medicine (miscellaneous) ,Health Informatics ,ISA ,Computer Science Applications - Abstract
Privacy by design within a system for assisted living, personalised care, and wellbeing is crucial to protect users from misuse of the data collected about their health. Especially if the information is collected through audio–video devices, the question is even more delicate due to the nature of these data. In addition to guaranteeing a high level of privacy, it is necessary to reassure end users about the correct use of these streams. The evolution of data analysis techniques began to take on an important role and increasingly defined characteristics in recent years. The purpose of this paper is twofold: on the one hand, it presents a state of the art about privacy in European Active Healthy Ageing/Active Healthy Ageing projects, with a focus on those related to audio and video processing. On the other hand, it proposes a methodology, developed in the context of the European project PlatfromUptake.eu, to identify clusters of stakeholders and application dimensions (technical, contextual, and business), define their characteristics, and show how privacy constraints affect them. From this study, we then generated a Strengths, Weaknesses, Opportunities, and Threats analysis in which we aim to identify the critical features connected to the selection and involvement of relevant stakeholders for the success of a project. Applying this type of methodology to the initial stages of a project allows understanding of which privacy issues could be related to the various stakeholder groups and which problems can then affect the correct development of the project. The idea is, therefore, to suggest a privacy-by-design approach according to the categories of stakeholders and project dimensions. The analysis will cover technical aspects, legislative and policies-related aspects also regarding the point of view of the municipalities, and aspects related to the acceptance and, therefore, to the perception of the safety of these technologies by the final end users.
- Published
- 2023
- Full Text
- View/download PDF
43. Busulfan or Treosulfan Conditioning Platform for Allogeneic Stem Cell Transplantation in Patients Aged >60 Y With Acute Myeloid Leukemia/Myelodysplastic Syndrome: A Subanalysis of the GITMO AlloEld Study
- Author
-
Malagola, M., Polverelli, N., Martino, M., Patriarca, F., Bruno, B., Giaccone, L., Grillo, G., Bramanti, S., Bernasconi, P., De Gobbi, M., Natale, A., Terruzzi, E., Olivieri, A., Chiusolo, P., Carella, A. M., Casini, M., Maffini, E., Nozzoli, C., Mazza, P., Bassi, S., Onida, F., Vacca, A., Falcioni, S., Luppi, M., Iori, A. P., Pavone, V., Skert, C., Carluccio, P., Borghero, C., Proia, A., Selleri, C., Rubini, V., Sacchi, N., Oldani, E., Bonifazi, F., Ciceri, F., Russo, D., Bernardi, S., Farina, M., Fiore, M., Lupo Stanghellini, M. T., Fanin, R., Faraci, D. G., Castagna, L., Colombo, A. A., Nicoli, P., Santarone, S., Scortechini, I., Metafuni, E., Merla, E., Cavattoni, I., Cutini, I., Mazzone, A., Saporiti, G., Canale, F. A., Piras, E., Galieni, P., Debbia, G., La Rocca, U., Mele, A., Carobolante, F., Elice, F., and Fanelli, F.
- Subjects
Busulfan ,Treosulfan ,stem cell transplant ,Transplantation - Published
- 2023
44. GAU-PED study for early diagnosis of Gaucher disease in children with splenomegaly and cytopenia
- Author
-
Pession, A., Di Rocco, M., Venturelli, F., Tappino, B., Morello, W., Santoro, N., Giordano, P., Filippini, B., Rinieri, S., Russo, G., Girardi, K., Ruggiero, A., Galea, E., Antonucci, R., Tovaglieri, N., Porta, F., Tartaglione, I., Giona, F., Fagioli, F., Burlina, A., Mura, R., Russo, B., Tornesello, A., Menna, G., Russo, D., Caniglia, M., Schettini, S., Onofrillo, D., Ladogana, S., and Civino, A.
- Subjects
Cytopenia ,Splenomegaly ,Lysosomal storage disease ,Gaucher disease ,Thrombocytopenia - Published
- 2023
45. Diagnostic issues faced by a rare disease healthcare network during Covid-19 outbreak: data from the Campania Rare Disease Registry
- Author
-
Limongelli G, Iucolano S, Monda E, Elefante P, De Stasio C, Lubrano I, Caiazza M, Mazzella M, Fimiani F, Galdo M, De Marchi G, Esposito M, Rubino M, Cirillo A, Fusco A, Esposito A, Trama U, Esposito S, Scarano G, Sepe J, Andria G, Orlando V, Menditto E, Chiodini P, Campania Rare Disease, Iolascon A, Franzese A, Sanduzzi Zamparelli A, Tessitore A, Romano A, Venosa A, Nunzia Olivieri A, Bianco A, La Manna A, Cerbone AM, Spasiano A, Agnese Stanziola A, Colao A, De Bellis A, Gambale A, Toriello A, Tufano A, Ciampa A, Maria Risitano A, Pisani A, Russo A, Volpe A, De Martino B, Amato B, De Fusco C, Piscopo C, Selleri C, Tucci C, Pignata C, Cioffi D, Melis D, Pasquali D, De Brasi D, Spitaleri D, Russo D, Martellotta D, De Michele E, Varricchio E, Miraglia Del Giudice E, Coscioni E, Cimino E, Pane F, Tranfa F, Pollio F, Lonardo F, Nuzzi F, Simonelli F, Trojsi F, Habetswallner F, Valentini G, Cerbone G, Parenti G, Tedeschi G, Capasso G, Battista Rossi G, Gaglione G, Sarnelli G, Argenziano G, Bellastella G, De Michele G, Fiorentino G, Spadaro G, Scala I, Santoro L, Zeppa L, Auricchio L, Elio Adinolfi L, Alessio M, Amitrano M, Savanelli MC, Russo MG, Ferrucci MG, Carbone MT, Pellecchia MT, Salerno M, Melone M, Del Donno M, Vitale M, Triggiani M, Della Monica M, Lo Presti M, Tenuta M, Mignogna MD, Schiavulli M, Zacchia M, Brunetti-Pierri N, Iovino P, Moscato P, Iandoli R, Scarpa R, Russo R, Troisi S, Sbordone S, Perrotta S, Fecarotta S, Sampaolo S, Cicalese V., Limongelli, Giuseppe, Iucolano, Stefano, Monda, Emanuele, Elefante, Pasquale, De Stasio, Chiara, Lubrano, Imma, Caiazza, Martina, Mazzella, Marialuisa, Fimiani, Fabio, Galdo, Maria, De Marchi, Giulia, Esposito, Martina, Rubino, Marta, Cirillo, Annapaola, Fusco, Adelaide, Esposito, Augusto, Trama, Ugo, Esposito, Salvatore, Scarano, Gioacchino, Sepe, Joseph, Andria, Generoso, Orlando, Valentina, Menditto, Enrica, Chiodini, Paolo, Iolascon, Achille, Franzese, Adriana, Sanduzzi Zamparelli, Alessandro, Tessitore, Alessandro, Romano, Alfonso, Venosa, Alfredo, Nunzia Olivieri, Alma, Bianco, Andrea, La Manna, Angela, Cerbone, Anna Maria, Spasiano, Anna, Agnese Stanziola, Anna, Colao, Annamaria, De Bellis, Annamaria, Gambale, Antonella, Toriello, Antonella, Tufano, Antonella, Ciampa, Antonio, Maria Risitano, Antonio, Pisani, Antonio, Russo, Antonio, Volpe, Antonio, De Martino, Bernardo, Amato, Bruno, De Fusco, Carmela, Piscopo, Carmelo, Selleri, Carmine, Tucci, Celeste, Pignata, Claudio, Cioffi, Daniela, Melis, Daniela, Pasquali, Daniela, De Brasi, Daniele, Spitaleri, Daniele, De Brasi, Davide, Russo, Domenico, Martellotta, Donata, De Michele, Elisa, Varricchio, Elziario, Miraglia Del Giudice, Emanuele, Coscioni, Enrico, Cimino, Ernesto, Pane, Fabrizio, Tranfa, Fausto, Pollio, Filiberto, Lonardo, Fortunato, Nuzzi, Francesca, Simonelli, Francesca, Trojsi, Francesca, Habetswallner, Francesco, Valentini, Gabriele, Cerbone, Gaetana, Parenti, Giancarlo, Tedeschi, Gioacchino, Capasso, Giovambattista, Battista Rossi, Giovanni, Gaglione, Giovanni, Sarnelli, Giovanni, Argenziano, Giuseppe, Bellastella, Giuseppe, De Michele, Giuseppe, Fiorentino, Giuseppe, Spadaro, Giuseppe, Scala, Iri, Santoro, Lucio, Zeppa, Lucio, Auricchio, Luigi, Elio Adinolfi, Luigi, Alessio, Maria, Amitrano, Maria, Savanelli, Maria Cristina, Russo, Maria Giovanna, Ferrucci, Maria Grazia, Carbone, Maria Teresa, Pellecchia, Maria Teresa, Salerno, Mariacarolina, Melone, Marina, Del Donno, Mario, Vitale, Mario, Triggiani, Massimo, Della Monica, Matteo, Lo Presti, Maurizio, Tenuta, Maurizio, Mignogna, Michele Davide, Schiavulli, Michele, Zacchia, Miriam, Brunetti-Pierri, Nicola, Iovino, Paola, Moscato, Paolo, Iandoli, Raffaele, Scarpa, Raffaele, Russo, Romualdo, Troisi, Salvatore, Sbordone, Sandro, Perrotta, Silverio, Fecarotta, Simona, Sampaolo, Simone, Cicalese, Virgilio, Limongelli, G, Iucolano, S, Monda, E, Elefante, P, De Stasio, C, Lubrano, I, Caiazza, M, Mazzella, M, Fimiani, F, Galdo, M, De Marchi, G, Esposito, M, Rubino, M, Cirillo, A, Fusco, A, Esposito, A, Trama, U, Esposito, S, Scarano, G, Sepe, J, Andria, G, Orlando, V, Menditto, E, Chiodini, P, Campania Rare, Disease, Iolascon, A, Franzese, A, Sanduzzi Zamparelli, A, Tessitore, A, Romano, A, Venosa, A, Nunzia Olivieri, A, Bianco, A, La Manna, A, Cerbone, Am, Spasiano, A, Agnese Stanziola, A, Colao, A, De Bellis, A, Gambale, A, Toriello, A, Tufano, A, Ciampa, A, Maria Risitano, A, Pisani, A, Russo, A, Volpe, A, De Martino, B, Amato, B, De Fusco, C, Piscopo, C, Selleri, C, Tucci, C, Pignata, C, Cioffi, D, Melis, D, Pasquali, D, De Brasi, D, Spitaleri, D, Russo, D, Martellotta, D, De Michele, E, Varricchio, E, Miraglia Del Giudice, E, Coscioni, E, Cimino, E, Pane, F, Tranfa, F, Pollio, F, Lonardo, F, Nuzzi, F, Simonelli, F, Trojsi, F, Habetswallner, F, Valentini, G, Cerbone, G, Parenti, G, Tedeschi, G, Capasso, G, Battista Rossi, G, Gaglione, G, Sarnelli, G, Argenziano, G, Bellastella, G, De Michele, G, Fiorentino, G, Spadaro, G, Scala, I, Santoro, L, Zeppa, L, Auricchio, L, Elio Adinolfi, L, Alessio, M, Amitrano, M, Savanelli, Mc, Russo, Mg, Ferrucci, Mg, Carbone, Mt, Pellecchia, Mt, Salerno, M, Melone, M, Del Donno, M, Vitale, M, Triggiani, M, Della Monica, M, Lo Presti, M, Tenuta, M, Mignogna, Md, Schiavulli, M, Zacchia, M, Brunetti-Pierri, N, Iovino, P, Moscato, P, Iandoli, R, Scarpa, R, Russo, R, Troisi, S, Sbordone, S, Perrotta, S, Fecarotta, S, Sampaolo, S, and Cicalese, V.
- Subjects
Pediatrics ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Home therapy ,rare diseases ,030204 cardiovascular system & hematology ,Campania region ,Covid-19 ,Italy ,patient registry ,Disease Outbreaks ,03 medical and health sciences ,COVID-19 Testing ,0302 clinical medicine ,Pandemic ,Health care ,medicine ,Retrospective analysis ,Humans ,AcademicSubjects/MED00860 ,Registries ,030212 general & internal medicine ,Medical diagnosis ,Pandemics ,Retrospective Studies ,business.industry ,Public Health, Environmental and Occupational Health ,Outbreak ,General Medicine ,Original Article ,business ,Delivery of Health Care ,Rare disease - Abstract
Background The aims of this study were: to investigate the capacity of the rare disease healthcare network in Campania to diagnose patients with rare diseases during the outbreak of Covid-19; and to shed light on problematic diagnoses during this period. Methods To describe the impact of the Covid-19 pandemic on the diagnosis of patients with rare diseases, a retrospective analysis of the Campania Region Rare Disease Registry was performed. A tailored questionnaire was sent to rare disease experts to investigate major issues during the emergency period. Results Prevalence of new diagnoses of rare disease in March and April 2020 was significantly lower than in 2019 (117 versus 317, P Conclusions This study describes the effects of the Covid-19 outbreak on the diagnosis of rare disease in a single Italian region and investigates potential issues of diagnosis and management during this period.
- Published
- 2021
46. 19 A large, multicenter, retrospective study on efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic ovarian cancer (MITO RT1 study)
- Author
-
Macchia, G, Lazzari, R, Colombo, N, Laliscia, C, Capelli, G, D’Agostino, GR, Deodato, F, Trippa, F, Ippolito, E, Ronchi, S, Pajar, F, Scorsetti, M, Cilla, S, Ingargiola, R, Huscher, A, Cerrotta, AM, Andrei, F, Vicenzi, L, Russo, D, Borghesi, S, Perrucci, E, Pignata, S, Aristei, C, Morganti, AG, Scambia, G, Valentini, V, Jereczek-Fossa, BA, and Ferrandina, G
- Published
- 2019
- Full Text
- View/download PDF
47. Expression and secretion of a lytic polysaccharide monooxygenase by a fast-growing cyanobacterium
- Author
-
Russo, D. A., Zedler, J. A. Z., Wittmann, D. N., Möllers, B., Singh, R. K., Batth, T. S., van Oort, B., Olsen, J. V., Bjerrum, M. J., and Jensen, P. E.
- Published
- 2019
- Full Text
- View/download PDF
48. The role of mesotherapy in the management of spinal pain. A randomized controlled study.
- Author
-
Brauneis, S., Araimo, F., Rossi, M., Russo, D., Mammucari, M., Maggiori, E., di Marzo, R., Vellucci, R., Gori, F., Bifarini, B., Chinè, E., Carpenedo, R., Paolucci, T., Giorgio, C., Ritarossi, F., Calò, A., Luongo, L., and Natoli, S.
- Subjects
MESOTHERAPY ,RANDOMIZED controlled trials ,CLINICAL trials ,DRUGS ,PROPOFOL - Abstract
Background. Mesotherapy is a technique through which active ingredients are administered into the thickness of the skin in order to increase the local analgesic effect. Methods. 141 patients with spinal pain not responding to systemic therapy with NSAIDs were randomized to receive one or more intracutaneous drugs on a weekly basis. Results. All patients achieved a pain reduction of at least 50% compared to baseline, and all tolerated the therapy without having to resort to systemic drug dose increases. Conclusions. The data from our study show that the active ingredients infiltrated into the skin induce a mesodermal modulation between the infiltrated liquid and the cutaneous nervous and cellular structures from which the typical drug-saving effect of mesotherapy arises. Although further studies are needed to establish how to integrate mesotherapy in various clinical settings, it appears to be a useful technique available to the practicing physician. This research is also useful in guiding future clinical research. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
49. Differences among young adults, adults and elderly chronic myeloid leukemia patients
- Author
-
Salvi, F., Pini, M., Leoni, P., Rupoli, S., Galieni, P., Bigazzi, C., Cantore, N., Palmieri, F., Albano, F., Russo Rossi, A., Rambaldi, A., Intermesoli, T., Palandri, F., Testoni, N., Luatti, S., Soverini, S., Iacobucci, I., Bochicchio, M.T., Apolinari, M., Fogli, M., Cervello, I., Capucci, A., Malagola, M., Malpignano, A., Girasoli, M., Angelucci, E., Usala, E., Storti, S., De Biasi, E., Tagariello, G., Sartori, R., Di Raimondo, F., Vigneri, P., Impera, S., Molica, S., Lanza, F., Viganò, C., Grasso, M., Rapezzi, D., Cavazzini, F., Bosi, A., Santini, V., Capalbo, S.F., Spinosa, G., Pierri, I., Bergamaschi, M., Carella, A.M., Bacigalupo, A., De Blasio, A., Ciccone, F., Di Renzo, N., Musolino, C., Russo, S., Cortelezzi, A., Morra, E., Pungolino, E.M., Luppi, M., Marasca, R., Pogliani, E.M., Gambacorti-Passerini, C., Luciano, L., Ferrara, F., Annunziata, M., Latte, G., Noli, D., Rege-Cambrin, G., Fava, C., Semenzato, G., Binotto, G., Fabbiano, F., Turri, D., Siragusa, S., Caracciolo, C., Musso, M., Porretto, F., Aversa, F., Crugnola, M., Cazzola, M., Orlandi, E., Falini, B., Falzetti, F., Visani, G., Isidori, A., Fioritoni, G., Di Lorenzo, R., Vallisa, D., Trabacchi, E., Petrini, M., Galimberti, S., Pizzuti, M., Zaccaria, A., Salvucci, M., Ronco, F., Ielo, D., Merli, F., Avanzini, P., Tosi, P., Merli, A., Musto, P., De Stefano, V., Sica, S., Latagliata, R., De Fabritiis, P., Trawiska, M., Majolino, I., Pacilli, L., Ronci, B., Cedrone, M., Petti, M.C., Pisani, F., Tafuri, A., Montefusco, E., Iuliano, F., Dore, F., Pardini, S., Bocchia, M., Defina, M., Liberati, A.M., Luzzi, D., Boccadoro, M., Ferrero, D., Vitolo, U., Gherlinzoni, F., Calistri, E., Fanin, R., Pizzolo, G., Meneghini, V., Rodighiero, F., D'Emilio, A., Castagnetti, F., Gugliotta, G., Baccarani, M., Breccia, M., Specchia, G., Levato, L., Abruzzese, E., Rossi, G., Iurlo, A., Martino, B., Pregno, P., Stagno, F., Cuneo, A., Bonifacio, M., Gobbi, M., Russo, D., Gozzini, A., Tiribelli, M., de Vivo, A., Alimena, G., Cavo, M., Martinelli, G., Pane, F., Saglio, G., and Rosti, G.
- Published
- 2015
- Full Text
- View/download PDF
50. Utilisation concomitante d’inhibiteurs de la pompe à protons et de thérapie ciblée : impact sur la durée de traitement par thérapie ciblée et la survie des patients atteints de mélanome métastatique
- Author
-
Poizeau, F., primary, Frédéric, B., additional, Lemaitre, F., additional, Tron, C., additional, Pracht, M., additional, Russo, D., additional, Dinulescu, M., additional, Lesimple, T., additional, Oger, E., additional, and Dupuy, A., additional
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.