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3,710 results on '"Russell, William"'

1. Title Page, Copyright

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

2. Index

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

3. A Family Practice

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

5. Notes

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

6. Bibliography

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

7. Cover

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

8. Afterword

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

14. Foreword

Author

Lindsey, William D., Russell, William L., and Ryan, Mary L.

Published
2020

15. Molecular mechanism of contactin 2 homophilic interaction

Author

Fan, Shanghua, Liu, Jianfang, Chofflet, Nicolas, Bailey, Aaron O, Russell, William K, Zhang, Ziqi, Takahashi, Hideto, Ren, Gang, and Rudenko, Gabby

Subjects
Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Neurological, adhesion molecule, contactins, cross-linking mass spectrometry, cryo-EM, molecular recognition mechanism, molecular specificity, neuronal guidance molecule, protein structure, protein:protein interaction, single-particle analysis, Biophysics
Abstract

Contactin 2 (CNTN2) is a cell adhesion molecule involved in axon guidance, neuronal migration, and fasciculation. The ectodomains of CNTN1-CNTN6 are composed of six Ig domains (Ig1-Ig6) and four FN domains. Here, we show that CNTN2 forms transient homophilic interactions (KD ∼200 nM). Cryo-EM structures of full-length CNTN2 and CNTN2_Ig1-Ig6 reveal a T-shaped homodimer formed by intertwined, parallel monomers. Unexpectedly, the horseshoe-shaped Ig1-Ig4 headpieces extend their Ig2-Ig3 tips outwards on either side of the homodimer, while Ig4, Ig5, Ig6, and the FN domains form a central stalk. Cross-linking mass spectrometry and cell-based binding assays confirm the 3D assembly of the CNTN2 homodimer. The interface mediating homodimer formation differs between CNTNs, as do the homophilic versus heterophilic interaction mechanisms. The CNTN family thus encodes a versatile molecular platform that supports a very diverse portfolio of protein interactions and that can be leveraged to strategically guide neural circuit development.

Published
2024

16. Examining Demographics and Perceived 'Sense of Community' of Social Media-Based Professional Learning Communities

Author

Hensley, Matt, Waters, Stewart, Russell, William, and Kenna, Joshua

Abstract

Social media has undoubtedly shifted the landscape of educator professional development in the 21st century. The establishment and development of identifiable professional learning communities (PLCs) like the #SSChat social studies community on Twitter enables educators to connect and collaborate with other professionals across the globe from their own mobile device. The purpose of this study was to determine the demographic features of the #SSChat members. Moreover, we sought to determine if there were any significant differences in #SSChat member's perceived 'Sense of Community' (SOC) based on those demographics. No statistically significant findings were discovered. Still, the demographic data provide good discussions.

Published
2023

20. Index

Author

Lull, Timothy F. and Russell, William R.

Published
2012

21. Glossary

Author

Lull, Timothy F. and Russell, William R.

Published
2012

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