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Your search keyword '"Russell, Mark H."' showing total 26 results
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26 results on '"Russell, Mark H."'

4. A site-specific screening comparison of modeled and monitored air dispersion and deposition for perfluorooctanoate

Author

Barton, Catherine A., Zarzecki, Charles J., and Russell, Mark H.

Subjects
Soil acidification -- Research, Air quality -- Models, Perfluorocarbons -- Research, Environmental services industry, Environmental issues, Science and technology
Abstract

ABSTRACT This work assessed the usefulness of a current air quality model (American Meteorological Society/Environmental Protection Agency Regulatory Model [AERMOD]) for predicting air concentrations and deposition of perfluorooctanoate (PFO) near [...]

Published
2010
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25. Renal elimination of perfluorocarboxylates (PFCAs).

Author

Han X, Nabb DL, Russell MH, Kennedy GL, and Rickard RW

Subjects
Animals, Humans, Models, Biological, Caprylates pharmacokinetics, Carboxylic Acids pharmacokinetics, Environmental Pollutants pharmacokinetics, Fluorocarbons pharmacokinetics, Kidney metabolism
Abstract

Sex-, species-, and chain length-dependent renal elimination is the hallmark of mammalian elimination of perfluorocarboxylates (PFCAs) and has been extensively studied for almost 30 years. In this review, toxicokinetic data of PFCAs (chain lengths ranging from 4 to 10) in different species are compared with an emphasis on their relevance to renal elimination. PFCAs vary in their affinities to bind to serum albumins in plasma, which is an important factor in determining the renal clearance of PFCAs. PFCA-albumin binding has been well characterized and is summarized in this review. The mechanism of the sex-, species-, and chain length-dependent renal PFCA elimination is a research area that has gained continuous interest since the beginning of toxicological studies of PFCAs. It is now recognized that organic anion transport proteins play a key role in PFCA renal tubular reabsorption, a process that is sex-, species-, and chain length-dependent. Recent studies on the identification of PFCA renal transport proteins and characterization of their transport kinetics have greatly improved our understanding of the PFCA renal transport mechanism at the molecular level. A mathematical representation of this renal tubular reabsorption mechanism has been incorporated in physiologically based pharmacokinetic (PBPK) modeling of perfluorooctanoate (PFOA). Improvement of PBPK models in the future will require more accurate and quantitative characterization of renal transport pathways of PFCAs. To that end, a basolateral membrane efflux pathway for the reabsorption of PFCAs in the kidney is discussed in this review, which could provide a future research direction toward a better understanding of the mechanisms of PFCA renal elimination.

Published
2012
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