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4. Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19.

Author

Hannah Chung, Campitelli, Michael A., Buchan, Sarah A., Campigotto, Aaron, Crowcroft, Natasha S., Gubbay, Jonathan B., Jung, James K. H., Karnauchow, Timothy, Katz, Kevin, McGeer, Allison J., McNally, J. Dayre, Richardson, David C., Richardson, Susan E., Rosella, Laura C., Russell, Margaret L., Schwartz, Kevin L., Simor, Andrew, Smieja, Marek, Sundaram, Maria E., and Warshawsky, Bryna F.

Published
2024
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8. Randomized evaluation of live attenuated vs. inactivated influenza vaccines in schools (RELATIVES) cluster randomized trial: Pilot results from a household surveillance study to assess direct and indirect protection from influenza vaccination

Author

Kwong, Jeffrey C., Pereira, Jennifer A., Quach, Susan, Pellizzari, Rosana, Dusome, Edwina, Russell, Margaret L., Hamid, Jemila S., Feinberg, Yael, Winter, Anne-Luise, Gubbay, Jonathan B., Sirtonski, Brittany, Moher, Deanna, Sider, Doug, Finkelstein, Michael, and Loeb, Mark

Published
2015
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12. Impact of pharmacist administration of influenza vaccines on uptake in Canada

Author

Buchan, Sarah A., Rosella, Laura C., Finkelstein, Michael, Juurlink, David, Isenor, Jennifer, Marra, Fawziah, Patel, Anik, Russell, Margaret L., Quach, Susan, Waite, Nancy, and Kwong, Jeffrey C.

Subjects
Pharmacists -- Surveys -- Analysis -- Practice, Influenza vaccines -- Research, Pharmaceutical policy -- Analysis, Health
Abstract

BACKGROUND: Uptake of influenza vaccination in Canada remains suboptimal despite widespread public funding. To increase access, several provinces have implemented policies permitting pharmacists to administer influenza vaccines in community pharmacies. We examined the impact of such policies on the uptake of seasonal influenza vaccination in Canada. METHODS: We pooled data from the 2007-2014 cycles of the Canadian Community Health Survey (n = 481526). To determine the impact of influenza vaccine administration by pharmacists, we estimated the prevalence ratio for the association between the presence of a pharmacist policy and individual-level vaccine uptake using a modified Poisson regression model (dependent variable: vaccine uptake) with normalized weights while controlling for numerous health and sociodemographic factors. RESULTS: Across all survey cycles combined, 28.8% of respondents reported receiving a seasonal influenza vaccine during the 12 months before survey participation. Introduction of a policy for pharmacist administration of influenza vaccine was associated with a modest increase in coverage (2.2%) and an individual's likelihood of uptake (adjusted prevalence ratio 1.05, 95% confidence interval 1.02-1.08). INTERPRETATION: Uptake of influenza immunization was modestly increased in Canadian jurisdictions that allowed pharmacists to administer influenza vaccines., Despite widespread public funding for influenza vaccination in Canada, either for high-risk groups or the entire population depending on the province or territory, uptake remains suboptimal. (1) Numerous factors influence [...]

Published
2017
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13. Corrigendum to “A nested case-control study measuring pertussis vaccine effectiveness and duration of protection in Manitoba, Canada, 1992–2015: A Canadian Immunization Research Network Study” [Vaccine 37(48) (2019) 7132–7137]

Author

Wilkinson, Krista, primary, Righolt, Christiaan H., additional, Kwong, Jeffrey C., additional, Schwartz, Kevin L., additional, Russell, Margaret L., additional, Crowcroft, Natasha S., additional, and Mahmud, Salaheddin M., additional

Published
2022
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20. Adjuvanted trivalent influenza vaccine versus quadrivalent inactivated influenza vaccine in Hutterite Children: A randomized clinical trial

Author

Loeb, Mark, primary, Russell, Margaret L, additional, Kelly-Stradiotto, Caralyn, additional, Fuller, Nola, additional, Fonseca, Kevin, additional, Earn, David J.D., additional, Chokani, Khami, additional, Babiuk, Lorne, additional, Neupane, Binod, additional, Singh, Pardeep, additional, and Pullenayegum, Eleanor, additional

Published
2021
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25. Exploring the reasons for low pertussis vaccine effectiveness in Ontario, Canada, 2006–2008: a Canadian Immunization Research Network study

Author

Hughes, Stephanie L., primary, Kwong, Jeffrey C., additional, Schwartz, Kevin L., additional, Chen, Cynthia, additional, Johnson, Caitlin, additional, Li, Ye, additional, Marchand-Austin, Alex, additional, Bolotin, Shelly, additional, Jamieson, Frances B., additional, Drews, Steven J., additional, Russell, Margaret L., additional, Svenson, Lawrence W., additional, Mahmud, Salaheddin M., additional, and Crowcroft, Natasha S., additional

Published
2021
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29. The Good, Bad, and Ugly of Online Recruitment of Parents for Health-Related Focus Groups: Lessons Learned

Author

Quach, Susan, Pereira, Jennifer A, Russell, Margaret L, Wormsbecker, Anne E, Ramsay, Hilary, Crowe, Lois, Quan, Sherman D, and Kwong, Jeff

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundWe describe our experiences with identifying and recruiting Ontario parents through the Internet, primarily, as well as other modes, for participation in focus groups about adding the influenza vaccine to school-based immunization programs. ObjectiveOur objectives were to assess participation rates with and without incentives and software restrictions. We also plan to examine study response patterns of unique and multiple submissions and assess efficiency of each online advertising mode. MethodsWe used social media, deal forum websites, online classified ads, conventional mass media, and email lists to invite parents of school-aged children from Ontario, Canada to complete an online questionnaire to determine eligibility for focus groups. We compared responses and paradata when an incentive was provided and there were no software restrictions to the questionnaire (Period 1) to a period when only a single submission per Internet protocol (IP) address (ie, software restrictions invoked) was permitted and no incentive was provided (Period 2). We also compared the median time to complete a questionnaire, response patterns, and percentage of missing data between questionnaires classified as multiple submissions from the same Internet protocol (IP) address or email versus unique submissions. Efficiency was calculated as the total number of hours study personnel devoted to an advertising mode divided by the resultant number of unique eligible completed questionnaires . ResultsOf 1346 submitted questionnaires, 223 (16.6%) were incomplete and 34 (2.52%) did not meet the initial eligibility criteria. Of the remaining 1089 questionnaires, 246 (22.6%) were not from Ontario based on IP address and postal code, and 469 (43.1%) were submitted from the same IP address or email address (multiple submissions). In Period 2 vs Period 1, a larger proportion of questionnaires were submitted from Ontario (92.8%, 141/152 vs 75.1%, 702/937, P

Published
2013
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30. A multisite study of pertussis vaccine effectiveness by time since last vaccine dose from three Canadian provinces: A Canadian Immunization Research Network study

Author

Savage, Rachel D., primary, Bell, Christopher A., additional, Righolt, Christiaan H., additional, Wilkinson, Krista, additional, Schwartz, Kevin L., additional, Chen, Cynthia, additional, Bolotin, Shelly, additional, Deeks, Shelley L., additional, Drews, Steven J., additional, Jamieson, Frances B., additional, Johnson, Caitlin, additional, Kwong, Jeffrey C., additional, Mahmud, Salaheddin M., additional, Russell, Margaret L., additional, Simmonds, Kimberley A., additional, Svenson, Lawrence W., additional, and Crowcroft, Natasha S., additional

Published
2021
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32. Effect of influenza vaccination of children on infectious rates in Hutterite communities

Author

Loeb, Mark, Russell, Margaret L, Moss, Lorraine, Fonseca, Kevin, Fox, Julie, Earn, David J.D., Aoki, Fred, Horsman, Gregory, Van Caeseele, Paul, Chokani, Khami, Vooght, Mark, Babiuk, Lorne, Webby, Richard, and Walter, Stephen D.

Subjects
Influenza vaccines -- Usage, Influenza vaccines -- Health aspects, Influenza -- Prevention, Teenagers -- Health aspects, Youth -- Health aspects, Hutterian Brethren -- Health aspects, Children -- Health aspects
Abstract

A study was conducted to evaluate the benefits of influenza vaccination of children and adolescents in reducing and preventing infection rates in the rest of the community. Results revealed that such vaccination helped prevent the rest of the community from contracting influenza.

Published
2010

35. A Call for Caution in Use of Pertussis Vaccine Effectiveness Studies to Estimate Waning Immunity: A Canadian Immunization Research Network Study

Author

Crowcroft, Natasha S, primary, Schwartz, Kevin L, additional, Savage, Rachel D, additional, Chen, Cynthia, additional, Johnson, Caitlin, additional, Li, Ye, additional, Marchand-Austin, Alex, additional, Bolotin, Shelly, additional, Deeks, Shelley L, additional, Jamieson, Frances B, additional, Drews, Steven J, additional, Russell, Margaret L, additional, Svenson, Lawrence W, additional, Simmonds, Kimberley, additional, Righolt, Christiaan H, additional, Bell, Christopher, additional, Mahmud, Salaheddin M, additional, and Kwong, Jeffrey C, additional

Published
2020
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37. Randomized, double-blind, placebo-controlled trial to assess the rate of recurrence of oculorespiratory syndrome following influenza vaccination among persons previously affected

Author

Skowronski, Danuta M., De Serres, Gaston, Scheifele, David, Russell, Margaret L., Warrington, Richard, Davies, Dele H., Dionne, Marc, Duval, Bernard, Kellner, James, and MacDonald, Judy

Subjects
Statistics, Influenza viruses -- Risk factors, Pulmonary manifestations of general diseases -- Causes of, Communicable diseases -- Research, Health, Health care industry
Published
2003

38. Ocular and respiratory symptoms attributable to inactivated split influenza vaccine: evidence from a controlled trial involving adults. (Major Article)

Author

Scheifele, David W., Duval, Bernard, Russell, Margaret L., Warrington, Richard, DeSerres, Gaston, Skowronski, Danuta M., Dionne, Marc, Kellner, James, Davies, Dele, and MacDonald, Judy

Subjects
Influenza vaccines -- Adverse and side effects, Influenza vaccines -- Physiological aspects, Eye -- Abnormalities, Respiratory organs -- Abnormalities, Cardiopulmonary system, Health, Health care industry
Published
2003

39. Epidemiology and Clinical Outcomes of Hospitalizations for Acute Respiratory or Febrile Illness and Laboratory-Confirmed Influenza Among Pregnant Women During Six Influenza Seasons, 2010–2016

Author

Dawood, Fatimah S, primary, Garg, Shikha, primary, Fink, Rebecca V, primary, Russell, Margaret L, primary, Regan, Annette K, primary, Katz, Mark A, primary, Booth, Stephanie, primary, Chung, Hannah, primary, Klein, Nicola P, primary, Kwong, Jeffrey C, primary, Levy, Avram, primary, Naleway, Allison, primary, Riesel, Dan, primary, Thompson, Mark G, primary, Wyant, Brandy E, primary, and Fell, Deshayne B, primary

Published
2019
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50. A Call for Caution in Use of Pertussis Vaccine Effectiveness Studies to Estimate Waning Immunity: A Canadian Immunization Research Network Study.

Author

Crowcroft, Natasha S, Schwartz, Kevin L, Savage, Rachel D, Chen, Cynthia, Johnson, Caitlin, Li, Ye, Marchand-Austin, Alex, Bolotin, Shelly, Deeks, Shelley L, Jamieson, Frances B, Drews, Steven J, Russell, Margaret L, Svenson, Lawrence W, Simmonds, Kimberley, Righolt, Christiaan H, Bell, Christopher, Mahmud, Salaheddin M, and Kwong, Jeffrey C

Subjects
IMMUNIZATION, WHOOPING cough, IMMUNITY, WHOOPING cough vaccines
Abstract

Background Vaccine effectiveness (VE) studies provide essential evidence on waning vaccine-derived immunity, a major threat to pertussis control. We evaluated how study design affects estimates by comparing 2 case-control studies conducted in Ontario, Canada. Methods We compared results from a test-negative design (TND) with a frequency-matched design (FMD) case-control study using pertussis cases from 2005–2015. In the first study, we identified test-negative controls from the public health laboratory that diagnosed cases and, in the second, randomly selected controls from patients attending the same physicians that reported cases, frequency matched on age and year. We compared characteristics of cases and controls using standardized differences. Results In both designs, VE estimates for the early years postimmunization were consistent with clinical trials (TND, 84%; FMD, 89% at 1–3 years postvaccination) but diverged as time since last vaccination increased (TND, 41%; FMD, 74% by 8 years postvaccination). Overall, we observed lower VE and faster waning in the TND than the FMD. In the TND but not FMD, controls differed from cases in important confounders, being younger, having more comorbidities, and higher healthcare use. Differences between the controls of each design were greater than differences between cases. TND controls were more likely to be unvaccinated or incompletely vaccinated than FMD controls (P  < .001). Conclusions The FMD adjusted better for healthcare-seeking behavior than the TND. Duration of protection from pertussis vaccines is unclear because estimates vary by study design. Caution should be exercised by experts, researchers, and decision makers when evaluating evidence on optimal timing of boosters. [ABSTRACT FROM AUTHOR]

Published
2021
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