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1. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry

Author

Faravelli, Francesca, Pantaleoni, Chiara, Robert-Gnansia, Elisabeth, Cabral-Lim, Leonor, Čebular, Boštjan, De Marinis, Alejandro, Kälviäinen, Reetta, Khomeriki, Ketevan, Kiteva-Trencevska, Gordana, Kochen, Silvia, Kurthen, Martin, Luef, Gerhard, Martinez Ferri, Meritxell, Milovanović, Maja, Nakken, Karl Otto, Neufeld, Miri, Ohtani, Hideyuki, Russell, Aline, Safcák, Vladimír, Schmitz, Bettina, Specchio, Luigi Maria, Tettenborn, Barbara, van Puijenbroek, Eugene, Yu, Hsiang-Yu, Zarubova, Jana, Albretsen, Claus, Alvestad, Silje, Andersen, Noemi Becser, Antonini, Luisa, Arentsen, Jens, Aurlien, Dag, Barzinji, Ismael, Becerra Cuñat, Juan Luis, Bohorquez Morera, Natalia, Brodie, Martin J., Brodtkorb, Eylert, Broglio, Laura, Bruun Christensen, Elsebeth, Bušek, Petr, Cagnetti, Claudia, Canevini, Maria Paola, Carius, Astrid, Castro Vilanova, Maria Dolores, Cecconi, Michela, Chang, T-Y, Christensen, Jakob, De Maria, Giovanni, Dennig, Dieter, Diputado, Brenda, Ertresvåg, Janne Marit, Escartin, Toni, Flügel, Dominique, Forsom Sondal, Birgitte, Foschi, Nicoletta, Franza, Albertina, Fukushima, Katsuyuki, Gambardella, Antonio, Garamendi Ruiz, Iñigo, Gauffin, Helena, Gellert, Pia, Gjerstad, Leif, Gordon, Lisa, Haggag, Katrine, Halawa, Imad, Heikinheimo-Connell, Terttu, Hendgen, Tim, Hertz, Zarouhi, Hildenhagen, Odo, Hödl, Stephanie, Hogenesch, Ineke, Huuse Farmen, Anette, Inoue, Yushi, Juhl, Stefan, Kato, Masaaki, Kenou Van Rijckevorssel, Germaine, Kluck, E., Krijtová, Hana, Kumlien, Eva, Labate, Angelo, Lasch, Theresa, Lindsten, Hans, Listonova, Renata, Lossius, Rasmus, Lundgren, Anders, Malmgren, Kristina, Marečková, Iva, Marino, Daniela, Mattsson, Peter, McGonigal, Aileen, Miesczanleh, Katarzyna, Mizobuchi, Masahiro, Mostacci, Barbara, Müffelmann, Birgit, Navn, Uden, Nilsson, Anders, Oehl, Bernhard, Ortenzi, Andrea, Osseforth, Judith, Paggi, Aldo, Pastor, Eliana, Pedersen, Birthe, Petrenaite, Vaiva, Pignatta, Pietro, Pires, Isabel, Pistelli, Alessandra, Riuz Gimenez, Jesús Antonio, Rocchi, Raffaele, Rodam, Lone, Roivainen, Reina, Rytířová, Gisela, Samsonsen, Christian, Sansa Fayos, Gemma, Saukkonen, Anna Maija, Sikiric, Alma, Sopelana Garay, David, Steinhoff, Bernhard, Strandberg, Maria, Svendsen, Torleiv, Tauboll, Erik, Terada, Kiyohito, Trivisano, Marina, Turner, Katherine, Worm, Mogens, Zakharia, Elias, Zambrelli, Elena, Zarifi-Oskoie, Morteza, Tomson, Torbjörn, Battino, Dina, Bonizzoni, Erminio, Craig, John, Lindhout, Dick, Perucca, Emilio, Sabers, Anne, Thomas, Sanjeev V, and Vajda, Frank

Published
2018
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10. U.K. Epilepsy and Pregnancy Group

Author

Russell, Aline J.C., Craig, John J., Morrison, Patrick, Irwin, Beth, Waddell, Ruth, Parsons, Linda, Robertson, Iain, Guthrie, Eleanor, and Morrow, Jim I.

Published
2004

12. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry

Author

Tomson, Torbjörn, primary, Battino, Dina, additional, Bonizzoni, Erminio, additional, Craig, John, additional, Lindhout, Dick, additional, Perucca, Emilio, additional, Sabers, Anne, additional, Thomas, Sanjeev V, additional, Vajda, Frank, additional, Faravelli, Francesca, additional, Pantaleoni, Chiara, additional, Robert-Gnansia, Elisabeth, additional, Cabral-Lim, Leonor, additional, Čebular, Boštjan, additional, De Marinis, Alejandro, additional, Kälviäinen, Reetta, additional, Khomeriki, Ketevan, additional, Kiteva-Trencevska, Gordana, additional, Kochen, Silvia, additional, Kurthen, Martin, additional, Luef, Gerhard, additional, Martinez Ferri, Meritxell, additional, Milovanović, Maja, additional, Nakken, Karl Otto, additional, Neufeld, Miri, additional, Ohtani, Hideyuki, additional, Russell, Aline, additional, Safcák, Vladimír, additional, Schmitz, Bettina, additional, Specchio, Luigi Maria, additional, Tettenborn, Barbara, additional, van Puijenbroek, Eugene, additional, Yu, Hsiang-Yu, additional, Zarubova, Jana, additional, Albretsen, Claus, additional, Alvestad, Silje, additional, Andersen, Noemi Becser, additional, Antonini, Luisa, additional, Arentsen, Jens, additional, Aurlien, Dag, additional, Barzinji, Ismael, additional, Becerra Cuñat, Juan Luis, additional, Bohorquez Morera, Natalia, additional, Brodie, Martin J., additional, Brodtkorb, Eylert, additional, Broglio, Laura, additional, Bruun Christensen, Elsebeth, additional, Bušek, Petr, additional, Cagnetti, Claudia, additional, Canevini, Maria Paola, additional, Carius, Astrid, additional, Castro Vilanova, Maria Dolores, additional, Cecconi, Michela, additional, Chang, T-Y, additional, Christensen, Jakob, additional, De Maria, Giovanni, additional, Dennig, Dieter, additional, Diputado, Brenda, additional, Ertresvåg, Janne Marit, additional, Escartin, Toni, additional, Flügel, Dominique, additional, Forsom Sondal, Birgitte, additional, Foschi, Nicoletta, additional, Franza, Albertina, additional, Fukushima, Katsuyuki, additional, Gambardella, Antonio, additional, Garamendi Ruiz, Iñigo, additional, Gauffin, Helena, additional, Gellert, Pia, additional, Gjerstad, Leif, additional, Gordon, Lisa, additional, Haggag, Katrine, additional, Halawa, Imad, additional, Heikinheimo-Connell, Terttu, additional, Hendgen, Tim, additional, Hertz, Zarouhi, additional, Hildenhagen, Odo, additional, Hödl, Stephanie, additional, Hogenesch, Ineke, additional, Huuse Farmen, Anette, additional, Inoue, Yushi, additional, Juhl, Stefan, additional, Kato, Masaaki, additional, Kenou Van Rijckevorssel, Germaine, additional, Kluck, E., additional, Krijtová, Hana, additional, Kumlien, Eva, additional, Labate, Angelo, additional, Lasch, Theresa, additional, Lindsten, Hans, additional, Listonova, Renata, additional, Lossius, Rasmus, additional, Lundgren, Anders, additional, Malmgren, Kristina, additional, Marečková, Iva, additional, Marino, Daniela, additional, Mattsson, Peter, additional, McGonigal, Aileen, additional, Miesczanleh, Katarzyna, additional, Mizobuchi, Masahiro, additional, Mostacci, Barbara, additional, Müffelmann, Birgit, additional, Navn, Uden, additional, Nilsson, Anders, additional, Oehl, Bernhard, additional, Ortenzi, Andrea, additional, Osseforth, Judith, additional, Paggi, Aldo, additional, Pastor, Eliana, additional, Pedersen, Birthe, additional, Petrenaite, Vaiva, additional, Pignatta, Pietro, additional, Pires, Isabel, additional, Pistelli, Alessandra, additional, Riuz Gimenez, Jesús Antonio, additional, Rocchi, Raffaele, additional, Rodam, Lone, additional, Roivainen, Reina, additional, Rytířová, Gisela, additional, Samsonsen, Christian, additional, Sansa Fayos, Gemma, additional, Saukkonen, Anna Maija, additional, Sikiric, Alma, additional, Sopelana Garay, David, additional, Steinhoff, Bernhard, additional, Strandberg, Maria, additional, Svendsen, Torleiv, additional, Tauboll, Erik, additional, Terada, Kiyohito, additional, Trivisano, Marina, additional, Turner, Katherine, additional, Worm, Mogens, additional, Zakharia, Elias, additional, Zambrelli, Elena, additional, and Zarifi-Oskoie, Morteza, additional

Published
2018
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13. Changing antiepilepsy drug-prescribing trends in women with epilepsy in the UK and Ireland and the impact on major congenital malformations

Author

Kinney, Michael O, primary, Morrow, James, additional, Patterson, Chris C, additional, Campbell, Ellen, additional, Russell, Aline, additional, Smithson, Henry W, additional, Parsons, Linda, additional, Morrison, Patrick J, additional, Bromley, Rebecca, additional, Liggan, Brenda, additional, Delanty, Norman, additional, Irwin, Beth, additional, Hunt, Stephen J, additional, and Craig, John J, additional

Published
2018
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16. The care of pregnant women with epilepsy — a survey of obstetricians in Scotland

Author

Cairnie Vivien, J C Russell Aline, Macpherson Hilary, and J Brodie Martin

Subjects
Adult, Male, medicine.medical_specialty, Vitamin K, Attitude of Health Personnel, Clinical Neurology, Collaborative Care, Vitamin k, Ultrasonography, Prenatal, Epilepsy, Postal questionnaire, pre-pregnancy counselling, medicine, Humans, guidelines, General hospital, Psychiatry, Specialist care, Neurologic Examination, Patient Care Team, Pregnancy, epilepsy services, business.industry, Infant, Newborn, Abnormalities, Drug-Induced, General Medicine, Middle Aged, medicine.disease, Pregnancy Complications, Neurology, obstetric care, Family medicine, Anticonvulsants, Female, pregnancy, Neurology (clinical), Drug Monitoring, business, Breast feeding
Abstract

There is concern regarding the teratogenic risks of antiepileptic drugs (AEDs) and the effect of seizures during pregnancy. Pre-pregnancy assessment and collaboration with the patient's neurologist may improve outcome. This study examined by postal questionnaire how senior obstetricians in Scotland cared for their patients with epilepsy in March 1994. One hundred and nine of 127 (86%) practising obstetricians representative of those working in both teaching and district general hospitals in Scotland responded. Only 16% of district general hospital obstetricians had an accessible epilepsy clinic/service and 19% a neurologist. Only 21% of all respondents considered that pregnancy counselling was being provided by a neurologist/epilepsy specialist, and only 43% were usually able to organize combined specialist care with an interested physician/neurologist. Most (79%) were happy with the concept of collaborative care. Many were uncertain as to the importance of recording epilepsy severity, genetic aspects, making changes to AEDs, monitoring drug levels, the use of vitamin K and breast feeding. Sixty-four per cent did not change their management of labour. Twenty per cent were dissatisfied with the present care of their patients with epilepsy. Over 90% considered guidelines to be important. This survey demonstrates the need for existing epilepsy services to be more accessible to all obstetricians in Scotland, particularly for those working in district general hospitals.

Published
1996
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17. Child development following in utero exposure:levetiracetam vs sodium valproate

Author

Shallcross, R, Bromley, R L, Irwin, B, Bonnett, L J, Morrow, J, Baker, G A, Fryer, Alan, Kneen, Rachel, Banka, Siddharth, Briggs, Maria, Clayton-Smith, Jill, Mawer, George, Baker, Gus, Bromley, Rebecca, Dixon, Pete, Gummery, Alison, Shallcross, Rebekah, Kerr, Loretta, Craig, John, Hunt, Stephen, Irwin, Beth, Morrison, Patrick, Morrow, James, Delanty, Norman, Liggan, Brenda, Russell, Aline, Smithson, Henry, Parsons, Linda, and Robertson, Iain

Subjects
Pediatrics, medicine.medical_specialty, Levetiracetam, Population, Clinical Neurology, Epilepsy, Child Development, Cognition, Pregnancy, Humans, Medicine, education, Maternal-Fetal Exchange, Retrospective Studies, Valproic Acid, education.field_of_study, business.industry, Infant, Articles, medicine.disease, Piracetam, Child development, Pregnancy Complications, El Niño, Maternal Exposure, In utero, Child, Preschool, Prenatal Exposure Delayed Effects, Anticonvulsants, Female, Neurology (clinical), business, medicine.drug
Abstract

Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97).Children were recruited prospectively from 2 cohorts in the United Kingdom and assessed using the Griffiths Mental Development Scale (1996), aged24 months. Information regarding maternal demographics were collected and controlled for. This is an observational study with researchers not involved in the clinical management of the WWE.On overall developmental ability, children exposed to LEV obtained higher developmental scores when compared to children exposed to VPA (p0.001). When compared, children exposed to LEV did not differ from control children (p = 0.62) on overall development. Eight percent of children exposed to LEV in utero fell within the below average range (DQ score of84), compared with 40% of children exposed to VPA. After controlling for maternal epilepsy and demographic factors using linear regression analysis, exposure to LEV in utero was not associated with outcome (p = 0.67). Conversely, when compared with VPA exposure, LEV exposure was associated with higher scores for the overall developmental quotient (p0.001).Children exposed to LEV in utero are not at an increased risk of delayed early cognitive development under the age of 24 months. LEV may therefore be a preferable drug choice, where appropriate, for WWE prior to and of childbearing age.

Published
2011
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20. Malformation Risks Of Antiepileptic Drug Monotherapies In Pregnancy: An Update From The UK and Ireland Epilepsy and Pregnancy Registers (I8-2.005)

Author

Campbell, Ellen, primary, Kennedy, Fiona, additional, Russell, Aline, additional, Smithson, W, additional, Linda, Parsons, additional, Irwin, Beth, additional, Liggan, Brenda, additional, Delanty, Norman, additional, Morrison, Patrick, additional, Hunt, Stephen, additional, Craig, John, additional, and Morrow, Jim, additional

Published
2014
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21. Malformation Risks Of Antiepileptic Drug Monotherapies In Pregnancy: An Update From The UK and Ireland Epilepsy and Pregnancy Registers (S59.001)

Author

Campbell, Ellen, primary, Kennedy, Fiona, additional, Russell, Aline, additional, Smithson, W, additional, Linda, Parsons, additional, Irwin, Beth, additional, Liggan, Brenda, additional, Delanty, Norman, additional, Morrison, Patrick, additional, Hunt, Stephen, additional, Craig, John, additional, and Morrow, Jim, additional

Published
2014
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25. Single photon emission computed tomography in the identification of a new variant Creutzfeldt-Jakob disease: case reports

Author

de Silva, Rajith, Patterson, James, Hadley, Donald, Russell, Aline, Turner, Martin, and Zeidler, Martin

Subjects
Varieties, Creutzfeldt-Jakob disease -- Varieties, Single photon emission computed tomography, SPECT imaging
Abstract

New variant Creutzfeldt-Jakob disease may be associated with exposure to the causative agent of bovine spongiform encephalopathy.[1] Currently, a reliable diagnosis is possible only after neuropathological examination of the brain, [...]

Published
1998

26. The movement disorders of Coffin–Lowry syndrome

Author

Stephenson, John B.P., primary, Hoffman, Mary C., additional, Russell, Aline J.C., additional, Falconer, Jane, additional, Beach, Richard C., additional, Tolmie, John L., additional, McWilliam, Robert C., additional, and Zuberi, Sameer M., additional

Published
2005
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31. Levetiracetam in pregnancy.

Author

Mawhinney, Ellen, Craig, John, Morrow, Jim, Russell, Aline, Smithson, W. Henry, Parsons, Linda, Morrison, Patrick J., Liggan, Brenda, Irwin, Beth, Delanty, Norman, and Hunt, Stephen J.

Published
2013

32. Reading epilepsy.

Author

Miller, Sarah, Razvi, Saif, and Russell, Aline

Abstract

Reading epilepsy is a rare epilepsy syndrome triggered by language related activity, in particular reading. Here we describe a patient with reflex seizures brought on specifically by reading in Arabic. The types of reading epilepsy, their typical clinical features, probable pathophysiology and management are discussed. [ABSTRACT FROM AUTHOR]

Published
2010

33. The management of epilepsy in pregnancy.

Author

Russell, Aline

Abstract

The article focuses on the treatment of epilepsy in pregnancy. Good seizure control can be achieved with anti-epileptic drug (AED) therapy in approximately two thirds of patients, maximising the chance of leading a normal, seizure-free life. Lamotrigine is one of the newer AEDs that is now widely prescribed in Great Britain as a first choice because of its relatively low side-effect profile. For pregnancies exposed to more than 1,000mg of valproate a day, the major congenital malformations rate was 9.1 percent.

Published
2006

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