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Annual European Congress of Rheumatology, Madrid, SPAIN, JUN 14-17, 2017; International audience; Background Current therapeutic modalities for fibromyalgia syndrome (FMS) do not provide satisfactory results to a high percentage of patients and new approaches have to be explored.Objectives This randomised, double-blind, controlled study was aimed to assess the efficacy and safety of adding a new treatment of herbal medicine, specifically developed to improve the quality of life of patients with FMS (Fib-19–01), to the current therapeutic regimen.Methods In this double-blind, placebo-controlled study, females with FMS, insufficiently improved by their current treatments, were randomised in one of the 3 following arms: Patients of arm 1 received Fib-19–01, 1 tablet twice a day. Those of arm 2 received a food supplement claimed to have analgesic properties (FSAP), in a double-blind way, and patients of arm 3 continued the previous treatment. without adding anything else (NoT). All continued the conventional treatment throughout the 6 months of follow-up. Inclusion criteria: women suffering from FMS (ACR criteria) with a Fibromyalgia Index Questionnaire FIQ >46. The primary endpoint was the change in FIQ score between baseline (Day 0) and month 6 (M6). Secondary Criteria included variation between D0 and M6 of the following scores: Pichot scale, Pittsburgh Sleep Quality Index (PSQI) index, SF-12 mental and social, SF-12 physical, HAD scales for depression and anxiety. Statistical analysis: Comparison intra-group (D0-M6) and intergroup on the ITT population.Results The ITT and per protocol populations were constituted of 101 and 75 patients. They were not statistically different and were in accordance with that expected (age 49, BMI 25, high percentage of antidepressant and anticonvulsant treatments). FIQ decrease throughout the follow-up was significant only in the Fib-19–01 group; (p

Fertility in dairy cattle has declined continuously during the last years. In Switzerland low fertility is one of the most important culling reason. Therefore this trait complex is of great economic importance. But fertility traits are functional traits with low heritabilities. We performed GWAS in Brown Swiss and Holstein cattle for the fertility traits: non-return rate after 56 days in heifers (NRH) and cows (NRC); days between first and last insemination in heifers (FLIH) and cows (FLIC); and days to first service (DFS). We used deregressed breeding values as input phenotypes and imputed whole-genome sequence dosages as genotypes. In Holstein (2,336 to 3,257 individuals) we could not identify any significant region for any of the investigated traits. For Brown Swiss cattle (1,392 to 3,278 individuals) however we could identify a QTL on BTA 17 for NRH and FLIH. This locus also showed a suggestive association with NRC and FLIC. The region significantly associated to NRH and FLIH comprises 27 genes. Among the associated variants two non-synonymous variants in the genes GAS2L and ASCC2 could be identified. These two variants could be potentially causative ariants.

One of the factors influencing the accuracy of genomic prediction is the density of SNP data used for prediction. We used sequence genotypes from the 1000 Bull Genomes Project (Run 5) as reference data to impute the whole-genome sequences of around 22,000 Brown Swiss and 15,000 Holstein, Simmental and Swiss Fleckvieh cattle to whole-genome sequences. We used FImpute to obtain HD genotypes and imputed with Minimac from HD to sequence data (16,184,800 variants). We report here the results for non return-rate 56 in heifers which are available already for Brown Swiss. For effect estimation deregressed breeding values of 2,018 Brown Swiss bulls with reliabilities above 0.65 were used. We used the BayesC approach implemented in gbcpp. Accuracy of genomic prediction was calculated as the correlation between the deregressed breeding values and the predicted direct genomic breeding value in a set of 240 of young bulls with accurate breeding values. LD pruned sequence data (5,812,425 SNPs; r=0.412) and sequence data (12,973,772 SNPs; r=0.407) yielded a higher accuracy than 50k data (38,009 SNPs; r=0.400) and missense data (34,184 SNPs; r=0,372). The results will be further evaluated by investigating more traits and breeds.

Identification of QTL, especially of causative variants within QTL is still challenging. Higher SNP densities aid the identification and fine-mapping of QTL. Based on imputed sequence data we performed GWAS for udder traits in Brown Swiss cattle. The GWAS was performed using a mixed-model approach with deregressed breeding values as phenotypes. The traits investigated included: udder depth (UD), fore udder attachment (FUA), rear udder width (RUW), rear udder height (RUH), fore udder length (FUL), and central ligament (CL). We found significant associations on BTA 3 (UD, FUA), BTA 5 (UD), BTA 17 (FUL, RUW, CL) and BTA 20 (FUA). A single gene was located in the significantly associated regions on BTA 5 (ABCC9) and BTA 20 (HCN1). The region on BTA 17 spans almost 3 Mb and includes 74 genes (maximal region for all the traits combined) and the region on BTA 3 includes 91 genes across 3 Mb. We also looked for associated missense variants in these intervals. Neither for ABCC9 nor for HCN1 we could identify such a variant. On BTA 17 we identified 2 missense variants that were significantly associated with CL. On BTA 3, 11 missense variants were significantly associated with UD and/or FUA. The advantages of using imputed sequence data compared to SNP chip genotypes are mainly through the inclusion of potential causative variants.

The X-29A advanced technology demonstrator has shown the practicality and advantages of the capability to compute and display, in real time, aeroperformance flight results. This capability includes the calculation of the in-flight measured drag polar, lift curve, and aircraft specific excess power. From these elements many other types of aeroperformance measurements can be computed and analyzed. The technique can be used to give an immediate postmaneuver assessment of data quality and maneuver technique, thus increasing the productivity of a flight program. A key element of this new method was the concurrent development of a real-time in-flight net thrust algorithm, based on the simplified gross thrust method. This net thrust algorithm allows for the direct calculation of total aircraft drag.

Розглянуто роль сівозміни в підвищенні біологізації землеробства як одного із заходів контролю чисельності шкодочинних об’єктів та підвищення урожайності і якості урожаю. Показано вплив органічних добрив, побічної продукції озимої пшениці, гороху і кукурудзи на зерно, сидератів, а також поєднання органічних добрив з мінеральними на продуктивність і ураженість хворобами конюшини лучної., Рассмотрена роль севооборота в повышении биологизации земледелия как одного из мероприятий контроля численности вредоносных объектов и повышения урожайности и качества урожая. Показано влияние органических удобрений, побочной продукции озимой пшеницы, гороха и кукурузы на зерно, сидератов, а также совместное применение органических удобрений с минеральными на продуктивность и пораженность болезнями красного клевера., The paper deals with the problem of biologization of farming as one of the basic measures for controlling the harmful agent number and increasing the red clover yielding capacity. The paper also focuses on the effects of organic fertilizers, by-products of winter wheat, pea and corn on the grain and green manure quality as well as on the effects of the joint application of organic and mineral fertilizers on the red clover productivity and its susceptibility to diseases.

Досліджено найбільш поширені хвороби та їх вплив на продуктивність конюшини лучної в господарствах Північного Лісостепу України., The paper presents the most spread diseases and their effects on the red clover yielding capacity in the Northern Forest-Steppe zone of Ukraine., Исследованы наиболее распространенные болезни и их влияние на продуктивность клевера лугового в хозяйствах Северной Лесостепи Украины.

Background . Current therapeutic modalities for fibromyalgia (FM) do not provide satisfactory results and new approaches have to be explored. Objectives . To assess efficacy and safety of adding a phytotherapy treatment (Fib-19-01) to the current therapeutic regimen in patients with FM. Methods . Double-blind controlled trial: women with active FM (Fibromyalgia Index Questionnaire FIQ > 40) were randomised to receive Fib-19-01 or a food supplement (FS) undistinguishable from Fib-19-01 or no supplementary treatment (NoST). All continued the conventional therapy throughout the 6 month follow-up. Primary endpoint: change in FIQ between Day 0 and month 6 (M6). Secondary Criteria: variation over time FIQ ( repeated measurements), change in Pichot fatigue scale, Pittsburgh Sleep Quality Index (PSQI), SF-12 and Hospital Anxiety and Depression (HAD) scales. Results . 100 patients (Intent-To-Treat population) were analyzed. FIQ decreased significantly only in the Fib-19-01 group (P