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27 results on '"Rusin, Spencer"'

11. Markers of Eosinophilic Inflammation for Diagnosis of Eosinophilic Esophagitis and Proton Pump Inhibitor–Responsive Esophageal Eosinophilia: A Prospective Study

Author

Woosley, John T., Gebhart, Jessica H., Rusin, Spencer, Shaheen, Nicholas J., Speck, Olga, Covey, Shannon, Dellon, Evan S., Woodward, Kimberly, and Chen, Xiaoxin

Abstract

Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is challenging. We assessed whether immunohistochemical analysis of esophageal tissues for major basic protein (MBP), eotaxin3, and tryptase can be used in diagnosis of EoE and to differentiate EoE from PPI-REE.

Published
2014
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12. Association Between Body Mass Index and Clinical and Endoscopic Features of Eosinophilic Esophagitis

Author

Wolf, W. Asher, primary, Piazza, Nicholas A., additional, Gebhart, Jessica H., additional, Rusin, Spencer, additional, Covey, Shannon, additional, Higgins, Leana L., additional, Beitia, RoseMary, additional, Speck, Olga, additional, Woodward, Kimberly, additional, Cotton, Cary C., additional, Runge, Thomas M., additional, Eluri, Swathi, additional, Woosley, John T., additional, Shaheen, Nicholas J., additional, and Dellon, Evan S., additional

Published
2016
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16. A Woman with a Lower Lip Nodule: What Is Your Diagnosis?

Author

Sarma, Deba P., Chen, Mingui, Stevens, Todd, Albertson, Daniel, Rusin, Spencer, and Ortman, Stephanie

Subjects
integumentary system, Article Subject
Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE), also known as epitheliod hemangioma is an uncommon benign vascular tumor of the skin. It usually presents as nodules and erythema over the ears, forehead, or scalp. Histologically, the lesion is composed of a combination of immature blood vessels, endothelial cells with distinct epitheliod appearance and chronic inflammatory cell infiltration with numerous eosinophils. Such a case occurring on the lower lip of a 55-year-old woman is presented. The lesion was completely excised with clear margins. Surgical resection is the preferred mode of treatment and is curative.

Published
2011
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17. A Clinical Prediction Tool Identifies Cases of Eosinophilic Esophagitis Without Endoscopic Biopsy: A Prospective Study

Author

Dellon, Evan S, primary, Rusin, Spencer, additional, Gebhart, Jessica H, additional, Covey, Shannon, additional, Speck, Olga, additional, Woodward, Kimberly, additional, Higgins, Leana L, additional, Beitia, RoseMary, additional, Madanick, Ryan D, additional, Levinson, Sidney, additional, Woosley, John T, additional, and Shaheen, Nicholas J, additional

Published
2015
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19. Su1112 A Set of Clinical and Endoscopic Features Predicts the Presence of Eosinophilic Esophagitis With High Accuracy, Allowing Omission of Low-Yield Biopsies: Results From a Prospective Study

Author

Dellon, Evan S., primary, Rusin, Spencer, additional, Gebhart, Jessica H., additional, Covey, Shannon, additional, Speck, Olga, additional, Woodward, Kimberly, additional, Higgins, Leana L., additional, Beitia, RoseMary, additional, Madanick, Ryan D., additional, Levinson, Sidney E., additional, Woosley, John T., additional, and Shaheen, Nicholas J., additional

Published
2015
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21. Tu1130 Impact of Clinical and Endoscopic Features on BMI in Patients With Eosinophilic Esophagitis

Author

Wolf, W. Asher, primary, Gebhart, Jessica H., additional, Rusin, Spencer, additional, Covey, Shannon, additional, Higgins, Leana L., additional, Beitia, RoseMary, additional, Speck, Olga, additional, Woodward, Kimberly, additional, Cotton, Cary C., additional, Runge, Thomas, additional, Eluri, Swathi, additional, Woosley, John T., additional, Shaheen, Nicholas J., additional, and Dellon, Evan S., additional

Published
2015
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27. Distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy

Author

Dellon, Evan S, Speck, Olga, Covey, Shannon, Rusin, Spencer, Shaheen, Nicholas J, Woodward, Kimberly, and Woosley, John T

Subjects
animal structures, respiratory system, 3. Good health
Abstract

The variability of eosinophilic infiltrates in eosinophilic esophagitis is not well described. This study aimed to determine the distribution of esophageal eosinophilia and the utility of histologic cut-points for eosinophilic esophagitis diagnosis in subjects undergoing endoscopy. We performed a prospective study of adults undergoing outpatient endoscopy. Research protocol esophageal biopsies were obtained from all subjects. Incident cases of eosinophilic esophagitis were diagnosed per consensus guidelines. Biopsies were interpreted following a validated protocol, and maximum eosinophil counts (eosinophils per high-power field; eos/hpf) were determined. Histologic analyses were performed on a per-patient, per-biopsy, and per-hpf basis. There were 213 patients, yielding 923 esophageal biopsies with 4588 hpfs. Overall, 48 patients (23%), 165 biopsy fragments (18%), and 449 hpfs (10%) had ≥ 15 eos/hpf; most subjects had no or low levels of eosinophils. In the eosinophilic esophagitis cases, 119 biopsy fragments (63%) and 332 hpfs (36%) had ≥ 15 eos/hpf. There was a mean 104-fold difference between the lowest and highest hpf eosinophil count for the eosinophilic esophagitis patients; 85% of the biopsies from eosinophilic esophagitis cases also had at least one hpf with < 15 eos/hpf. The cut-point of 15 eos/hpf had a sensitivity of 100% and specificity of 96% for diagnosis of eosinophilic esophagitis. In conclusion, most patients have little to no esophageal eosinophilia. In patients with eosinophilic esophagitis, there was marked variability in the eosinophil counts by biopsy and by hpf within a given biopsy. Additionally, the 15 eos/hpf cut-point was highly sensitive and specific for eosinophilic esophagitis. Multiple esophageal biopsies from different locations should be obtained to optimize eosinophilic esophagitis diagnosis.

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