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2. Internet-Based Birth-Cohort Studies: Is This the Future for Epidemiology?

Author

Firestone, Ridvan, Cheng, Soo, Pearce, Neil, Douwes, Jeroen, Merletti, Franco, Pizzi, Costanza, Pivetta, Emanuele, Rusconi, Franca, and Richiardi, Lorenzo

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundInternational collaborative cohorts the NINFEA and the ELF studies are mother-child cohorts that use the internet for recruitment and follow-up of their members. The cohorts investigated the association of early life exposures and a wide range of non-communicable diseases. ObjectiveThe objective is to report the research methodology, with emphasis on the advantages and limitations offered by an Internet-based design. These studies were conducted in Turin, Italy and Wellington, New Zealand. MethodsThe cohorts utilized various online/offline methods to recruit participants. Pregnant women who became aware volunteered, completed an online questionnaire, thus obtaining baseline information. ResultsThe NINFEA study has recruited 7003 pregnant women, while the ELF study has recruited 2197 women. The cohorts targeted the whole country, utilizing a range of support processes to reduce the attrition rate of the participants. For the NINFEA and ELF cohorts, online participants were predominantly older (35% and 28.9%, respectively), highly educated (55.6% and 84.9%, respectively), and were in their final trimester of pregnancy (48.5% and 53.6%, respectively). ConclusionsInternet-based cohort epidemiological studies are feasible, however, it is clear that participants are self-selective samples, as is the case for many birth cohorts. Internet-based cohort studies are potentially cost-effective and novel methodology for conducting long-term epidemiology research. However, from our experience, participants tend to be self-selective. In marked time, if the cohorts are to form part of a larger research program they require further use and exploration to address biases and overcome limitations.

Published
2015
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4. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis

Author

Golab, Bernadeta Patro, Santos, Susana, Voerman, Ellis, Lawlor, Debbie A, Jaddoe, Vincent WV, Gaillard, Romy, Authors, MOCO Study Group, Barros, Henrique, Bergström, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbø, Merete, Ekström, Sandra, Fantini, Maria P, Farchi, Sara, Forastiere, Francesco, Georgiu, Vagelis, Godfrey, Keith M, Gori, Davide, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Inskip, Hazel, Ibarluzea, Jesus, Kenny, Louise C, Küpers, Leanne K, Lagström, Hanna, Lehmann, Irina, Lenters, Virissa, Llop, Sabrina Llop, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yannis, McAuliffe, Fionnuala M, McDonald, Sheila W, Mehegan, John, Mommers, Monique, Morgen, Camilla S, Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ní, Nøhr, Ellen A, Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriëtte JJM, Pac, Agnieszka, Papadopoulou, Eleni, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Rusconi, Franca, Santos, Ana C, Smit, Henriette A, Sørensen, Thorkild IA, Standl, Marie, Stoltenberg, Camilla, Sunyer, Jordi, Taylor, Michelle, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C, Trnovec, Tomas, Turner, Steve, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja, West, Jane, Wright, John, and Zvinchuk, Oleksandr

Subjects
Nutrition, Contraception/Reproduction, Pediatric, Obesity, Prevention, Clinical Research, Cardiovascular, Perinatal Period - Conditions Originating in Perinatal Period, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Reproductive health and childbirth, Adolescent, Animals, Body Mass Index, Child, Child, Preschool, Diabetes, Gestational, Europe, Female, Humans, Hypertension, Pregnancy-Induced, Life Style, North America, Pediatric Obesity, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Risk Factors, MOCO Study Group Authors
Abstract

BackgroundGestational diabetes and gestational hypertensive disorders are associated with offspring obesity, but the role of maternal adiposity in these associations remains unclear. We aimed to investigate whether these pregnancy complications affect the odds of offspring obesity independently of maternal obesity.MethodsWe did an individual participant data (IPD) meta-analysis of mother-offspring pairs from prospective birth cohort studies that had IPD on mothers with singleton liveborn children born from 1989 onwards and had information available about maternal gestational diabetes, gestational hypertension or pre-eclampsia, and childhood body-mass index (BMI). We applied multilevel mixed-effects models to assess associations of gestational diabetes, gestational hypertension, and pre-eclampsia with BMI SD scores and the odds of overweight and obesity throughout childhood, adjusting for lifestyle characteristics (offspring's sex, maternal age, educational level, ethnicity, parity, and smoking during pregnancy). We then explored the extent to which any association was explained by maternal pre-pregnancy or early-pregnancy BMI.Findings160 757 mother-offspring pairs from 34 European or North American cohorts were analysed. Compared with uncomplicated pregnancies, gestational diabetes was associated with increased odds of overweight or obesity throughout childhood (odds ratio [OR] 1·59 [95% CI 1·36 to 1·86] for early childhood [age 2·0-4·9 years], 1·41 [1·26 to 1·57] for mid childhood [5·0-9·9 years], and 1·32 [0·97 to 1·78] for late childhood [10·0-17·9 years]); however, these associations attenuated towards the null following adjustment for maternal BMI (OR 1·35 [95% CI 1·15 to 1·58] for early childhood, 1·12 [1·00 to 1·25] for mid childhood, and 0·96 [0·71 to 1·31] for late childhood). Likewise, gestational hypertension was associated with increased odds of overweight throughout childhood (OR 1·19 [95% CI 1·01 to 1·39] for early childhood, 1·23 [1·15 to 1·32] for mid childhood, and 1·49 [1·30 to 1·70] for late childhood), but additional adjustment for maternal BMI largely explained these associations (1·01 [95% CI 0·86 to 1·19] for early childhood, 1·02 [0·95 to 1·10] for mid childhood, and 1·18 [1·03 to 1·36] for late childhood). Pre-eclampsia was associated with decreased BMI in early childhood only (difference in BMI SD score -0·05 SD score [95% CI -0·09 to -0·01]), and this association strengthened following additional adjustment for maternal BMI.InterpretationAlthough lowering maternal risk of gestational diabetes, gestational hypertension, and pre-eclampsia is important in relation to maternal and fetal pregnancy outcomes, such interventions are unlikely to have a direct impact on childhood obesity. Preventive strategies for reducing childhood obesity should focus on maternal BMI rather than on pregnancy complications.FundingEU's Horizon 2020 research and innovation programme (LifeCycle Project).

Published
2018

8. Variations in Neonatal Length of Stay of Babies Born Extremely Preterm: An International Comparison Between iNeo Networks

Author

Lui, Kei, Marshall, Peter, Schmidt, Peter, Dhawan, Anjali, Korostenski, Larissa, Travadi, Javeed Travadi, Sharp, Mary, Gill, Andy, Pillow, Jane, Stack, Jacqueline, Birch, Pita, Nothdurft, Karen, Cooke, Lucy, Casalaz, Dan, Holberton, Jim, Stewart, Alice, Downe, Lyn, Stewart, Michael, Berry, Andrew, Hunt, Rod, Morris, Peter, Paoli, Tony De, Bolisetty, Srinivas, Paradisis, Mary, Greenhalgh, Mark, Koorts, Pieter, Kuschel, Carl, Jacobs, Sue, Doyle, Lex, Craven, John, Numa, Andrew, Carlisle, Hazel, Badawi, Nadia, Popat, Himanshu, Koh, Guan, Davis, Jonathan, Luig, Melissa, Headley, Bevan, Andersen, Chad, Ng, Linda, Chambers, Georgina, Austin, Nicola, Lynn, Adrienne, Darlow, Brian, Edmonds, Liza, Mildenhall, Lindsay, Buksh, Mariam, Battin, Malcolm, Boom, Jutta van den, Richardson, Vaughan, Barker, David, Hammond, Barbara, Rajadurai, Victor Samuel, Lam, Simon, Fung, Genevieve, Shah, Prakesh S., Beltempo, Marc, Kanungo, Jaideep, Ting, Joseph, Cieslak, Zenon, Sherlock, Rebecca, Mehrem, Ayman Abou, Toye, Jennifer, Aziz, Khalid, Fajardo, Carlos, Bodani, Jaya, Strueby, Lannae, Seshia, Mary, Louis, Deepak, Alvaro, Ruben, Mukerji, Amit, Da Silva, Orlando, Adie, Mohammad, Lee, Kyong-Soon, Ng, Eugene, Lemyre, Brigitte, Daboval, Thierry, Khurshid, Faiza, Pelausa, Ermelinda, Barrington, Keith, Lapoint, Anie, Ethier, Guillaume, Drolet, Christine, Piedboeuf, Bruno, Claveau, Martine, St-Hilaire, Marie, Bertelle, Valerie, Masse, Edith, Canning, Roderick, Makary, Hala, Ojah, Cecil, Monterrosa, Luis, Emberley, Julie, Afifi, Jehier, Kajetanowicz, Andrzej, Lee, Shoo K., Metsäranta, Marjo, Lehtonen, Liisa, Tammela, Outi, Sankilampi, Ulla, Saarela, Timo, Morag, Iris, Zangen, Shmuel, Smolkin, Tatyana, Mimouni, Francis, Bader, David, Rothschild, Avi, Strauss, Zipora, Felszer, Clari, Omari, Hussam, Tov-Friedman, Smadar Even, Bar-Oz, Benjamin, Feldman, Michael, Saad, Nizar, Flidel-Rimon, Orna, Weisbrod, Meir, Lubin, Daniel, Litmanovitz, Ita, Kugelman, Amir, Shinwell, Eric, Klinger, Gil, Nijim, Yousif, Bin-Nun, Alona, Golan, Agneta, Mandel, Dror, Fleisher-Sheffer, Vered, Oron, Anat, Bakhrakh, Lev, Hattori, Satoshi, Shirai, Masaru, Ishioka, Toru, Mori, Toshihiko, Amizuka, Takasuke, Huchimukai, Toru, Yoshida, Hiroshi, Sasaki, Ayako, Shimizu, Junichi, Nakamura, Toshihiko, Maruyama, Mami, Matsumoto, Hiroshi, Hosokawa, Shinichi, Taki, Atsuko, Nakagawa, Machiko, Ko, Kyone, Uozumi, Azusa, Nakata, Setsuko, Shimazaki, Akira, Yoda, Tatsuya, Numata, Osamu, Imamura, Hiroaki, Kobayashi, Azusa, Tokuriki, Shuko, Uchida, Yasushi, Arai, Takahiro, Ito, Mitsuhiro, Ieda, Kuniko, Ono, Toshiyuki, Hayashi, Masashi, Maki, Kanemasa, Yamakawa, MieToru, Kawai, Masahiko, Fujii, Noriko, Shiomi, Kozue, Nozaki, Koji, Wada, Hiroshi, Kim, Taho, Tokunaga, Yasuyuki, Takatera, Akihiro, Oshima, Toshio, Sumida, Hiroshi, Michinomae, Yae, Kusumoto, Yoshio, Yoshimoto, Seiji, Morisawa, Takeshi, Ohashi, Tamaki, Takahashi, Yukihiro, Sugimoto, Moriharu, Ono, Noriaki, Miyagawa, Shinichiro, Saijo, Takahiko, Yamagami, Takashi, Koyano, Kosuke, Kobayashi, Shoko, Kanda, Takeshi, Sakemi, Yoshihiro, Aoki, Mikio, Iida, Koichi, Goshi, Mitsushi, Maruyama, Yuko, Avila-Alvarez, Alejandro, Fernandez-Trisac, José Luis, Pico, M<ce:sup loc='post">a</ce:sup> Luz Couce, Fernández Seara, María José, Gutiérrez, Andrés Martínez, Vizcaíno, Carolina, Iglesias, Miriam Salvador, Zaplana, Honorio Sánchez, Colomer, Belén Fernández, García López, José Enrique, Mozo, Rafael García, González Martínez, M. Teresa, Sebastián, M<ce:sup loc='post">a</ce:sup> Dolores Muro, Carbonell, Marta Balart, Barnusell, Joan Badia, Puiggròs, Mònica Domingo, Aloy, Josep Figueras, Mussons, Francesc Botet, Sanz, Israel Anquela, Galiana, Gemma Ginovart, Coroleu, W., Iriondo, Martin, Vilella, Laura Castells, Porta, Roser, Demestre, Xavier, Nadal, Silvia Martínez, de Frutos Martínez, Cristina, López Cuesta, María Jesús, Mora, Dolores Esquivel, Tardío, Joaquín Ortiz, Benavente, Isabel, Alonso, Almudena, Olmos, Ramón Aguilera, García Cabezas, Miguel A., Jiménez, M<ce:sup loc='post">a</ce:sup> Dolores Martínez, Caballero, M<ce:sup loc='post">a</ce:sup> Pilar Jaraba, Díaz, M<ce:sup loc='post">a</ce:sup> Dolores Ordoñez, Fagundo, Alberto Trujillo, Canals, Lluis Mayol, García-Muñoz Rodrigo, Fermín, Martí, Lourdes Urquía, Moreno Galdo, María Fernanda, Suazo, José Antonio Hurtado, López, Eduardo Narbona, Fernández, José Uberos, Cortajarena Altuna, Miguel A., Zuriarrain, Oihana Muga, Navarro, David Mora, Domínguez, María Teresa, Ruiz del Prado, M<ce:sup loc='post">a</ce:sup> Yolanda, Díez, Inés Esteban, Palau Benavides, María Teresa, Lapeña, Santiago, Prada, Teresa, Mir, Eduard Soler, Sánchez, Araceli Corredera, Vega, Enrique Criado, Prado, Náyade del, Fernández, Cristina, Vilaplana, Lucía Cabanillas, Pérez, Irene Cuadrado, Gómez, Luisa López, Comeche, Laura Domingo, Martín, Isabel Llana, Armengod, Carmen González, Labián, Carmen Muñoz, Muñoz, M<ce:sup loc='post">a</ce:sup> José Santos, Bravo, Dorotea Blanco, Pérez, Vicente, Fernández, M<ce:sup loc='post">a</ce:sup> Dolores Elorza, González, Celia Díaz, Segura, Susana Ares, Azorín, Manuela López, Jimenez, Ana Belén, Sánchez-Tamayo, Tomás, Moreno, Elías Tapia, González, María, Sánchez Martínez, José Enrique, Lloreda García, José María, Orayen, Concepción Goñi, González, Javier Vilas, Albo, María Suárez, Colmenero, Eva González, Gutiérrez González, Elena Pilar, Vacas del Arco, Beatriz, Fernández, Josefina Márquez, Gordillo, Laura Acosta, Asensio, Mercedes Granero, Díaz, Carmen Macías, Albújar, Mar, Jorge, Pedro Fuster, Romero, Sabina, Falero, Mónica Rivero, Escobar Izquierdo, Ana Belén, Capell, Javier Estañ, Macián, M<ce:sup loc='post">a</ce:sup> Isabel Izquierdo, Vicente, M<ce:sup loc='post">a</ce:sup> Mar Montejo, Caballero, Raquel Izquierdo, Martínez, M<ce:sup loc='post">a</ce:sup> Mercedes, Euba, Aintzane, Serna, Amaya Rodríguez, López de Heredia Goya, Juan María, Legorburu, Alberto Pérez, Amorós, Ana Gutiérrez, Marugán Isabel, Víctor Manuel, González, Natalio Hernández, Gracia, Segundo Rite, Faci, M<ce:sup loc='post">a</ce:sup> Purificación Ventura, Villagrasa, M<ce:sup loc='post">a</ce:sup> Pilar Samper, Kofron, Jiri, Brodd, Katarina Strand, Odlind, Andreas, Alberg, Lars, Arwehed, Sofia, Hafström, Ola, Kasemo, Anna, Nederman, Karin, Åhman, Lars, Ingemarsson, Fredrik, Petersson, Henrik, Thurn, Pernilla, Albinsson, Eva, Selander, Bo, Abrahamsson, Thomas, Heimdahl, Ingela, Sveinsdottir, Kristbjorg, Wejryd, Erik, Hedlund, Anna, Söderberg, Maria Katarina, Navér, Lars, Brune, Thomas, Bäckström, Jens, Robinson, Johan, Farooqi, Aijaz, Normann, Erik, Fredriksson, Magnus, Palm, Anders, Rosenqvist, Urban, Walde, Bengt, Hagman, Cecilia, Ohlin, Andreas, Florell, Rein, Smedsaas-Löfvenberg, Agneta, Adams, Mark, Meyer, Philipp, Kusche, Rachel, Schulzke, Sven, Nelle, Mathias, Wagner, Bendicht, Riedel, Thomas, Kaczala, Grégoire, Pfister, Riccardo E., Tolsa, Jean-François, Roth, Matthias, Stocker, Martin, Laubscher, Bernhard, Malzacher, Andreas, Micallef, John P., Hegi, Lukas, Bassler, Dirk, Arlettaz, Romaine, Bernet, Vera, Dani, Carlo, Fiorini, Patrizio, Ghirri, Paolo, Tomasini, Barbara, Mittal, Anita, Kefas, Jonathan, Kamalanathan, Anand, Grosdenier, Michael, Dewhurst, Christopher, Bontea, Andreea, Webb, Delyth, Garr, Ross, Hassan, Ahmed, Ambadkar, Priyadarshan, Dyke, Mark, McDevitt, Katharine, Rewitzky, Glynis, D'Amore, Angela, Kamath, P., Settle, Paul, Maddock, Natasha, Edi-Osagie, Ngozi, Zipitis, Christos, Heal, Carrie, Birch, Jacqeline, Hasib, Abdul, Soe, Aung, Abdul-Malik, Bushra, Kisat, Hamudi, Vasu, Vimal, Sivashankar, Savi, Gupta, Richa, Rawlingson, Chris, Wickham, Tim, Theron, Marice, Kendall, Giles, Gupta, Aashish, Aladangady, Narendra, Ali, Imdad, Jain, Neeraj, Mannan, Khalid, Murthy, Vadivelam, Sullivan, Caroline, Chuang, Shu-Ling, Bate, Tristan, Tyszcuzk, Lidia, Lee, Geraint, Obi, Ozioma, Chang, John, Pai, Vinay, Huddy, Charlotte, Yasin, Salim, Nicholl, Richard, Pandey, Poornima, Cusack, Jonathan, Kairamkonda, Venkatesh, Muogbo, Dominic, Harry, Liza, Surana, Pinki, Broggio, Penny, Pillay, Tilly, Deshpande, Sanjeev, Mahadevan, Moore, Alison, Bastani, Porus, Garbash, Mehdi, Lal, Mithilesh, Abu-Harb, Majd, Allwood, Alex, Selter, Michael, Munyard, Paul, Bartle, David, Paul, Siba, Whincup, Graham, Rekha, Sanghavi, Amess, Philip, Obi, Ben, Reynolds, Peter, Misra, Indranil, De Halpert, Peter, Salgia, Sanjay, Sanghavi, Rekha, Paul, Nicola, Deketelaere, Abby, Khashu, Minesh, Johnson, Mark, Groves, Charlotte, Baird, Jim, Brennan, Nick, Vamvakiti, Katia, McIntyre, John, Holman, Jennifer, Jones, Stephen, Pike, Alison, Cairns, Pamela, Eaton, Megan, Schwarz, Karin, Gibson, David, Miall, Lawrence, Krishnamurthy, Dr, Narayanan, Sankara, Seaton, Sarah E., Draper, Elizabeth S., Kusuda, Satoshi, Håkansson, Stellan, Helenius, Kjell, Reichman, Brian, Vento, Maximo, Darlow, Brian A., Rusconi, Franca, Isayama, Tetsuya, Norman, Mikael, Yang, Junmin, and Modi, Neena

Published
2021
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10. A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism

Author

Alfano, Rossella, Chadeau-Hyam, Marc, Ghantous, Akram, Keski-Rahkonen, Pekka, Chatzi, Leda, Perez, Almudena Espin, Herceg, Zdenko, Kogevinas, Manolis, de Kok, Theo M., Nawrot, Tim S., Novoloaca, Alexei, Patel, Chirag J., Pizzi, Costanza, Robinot, Nivonirina, Rusconi, Franca, Scalbert, Augustin, Sunyer, Jordi, Vermeulen, Roel, Vrijheid, Martine, Vineis, Paolo, Robinson, Oliver, and Plusquin, Michelle

Published
2020
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15. Severe asthma (SA) in children: data from the Italian society for paediatric respiratory diseases (SIMRI) database

Author

Carraro, Silvia, primary, Piazza, Michele, additional, Carella, Francesco, additional, Cinicola, Bianca, additional, Del Colle, Anna, additional, Di Cicco, Maria Elisa, additional, Fainardi, Valentina, additional, Fenu, Grazia, additional, Fontijn, Simone, additional, Ghezzi, Michele, additional, Giovannini, Mattia, additional, Kantar, Ahmad, additional, Licari, Amelia, additional, Manti, Sara, additional, Mazza, Angelo, additional, Nenna, Raffaella, additional, Niccoli, Antonio Augusto, additional, Piotto, Marta, additional, Raso, Massimiliano, additional, Tenero, Laura, additional, Trincianti, Chiara, additional, Francavilla, Andrea, additional, and Rusconi, Franca, additional

Published
2023
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16. Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts

Author

Strandberg-Larsen, Katrine, Poulsen, Gry, Bech, Bodil Hammer, Chatzi, Leda, Cordier, Sylvaine, Dale, Maria Teresa Grønning, Fernandez, Marieta, Henriksen, Tine Brink, Jaddoe, Vincent WV, Kogevinas, Manolis, Kruithof, Claudia J., Lindhard, Morten Søndergaard, Magnus, Per, Nohr, Ellen Aagaard, Richiardi, Lorenzo, Rodriguez-Bernal, Clara L., Rouget, Florence, Rusconi, Franca, Vrijheid, Martine, and Andersen, Anne-Marie Nybo

Published
2017

17. Did changes in conception rates alone account for the decline in preterm births during the first year of the COVID-19 pandemic?

Author

Rusconi, Franca, primary, Gagliardi, Luigi, additional, Pacifici, Martina, additional, Puglia, Monia, additional, Brescianini, Sonia, additional, Nannavecchia, Anna Maria, additional, Cantoira, Sara, additional, Formisano, Debora, additional, Gobbato, Michele, additional, Leoni, Olivia, additional, Mazzuccato, Monica, additional, Polo, Arianna, additional, Pertile, Riccardo, additional, Scoppa, Alessandro, additional, and Tavormina, Elisa Eleonora, additional

Published
2023
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20. The Impact of Parental Smoking on Asthma and Wheezing

Author

Agabiti, Nera, Mallone, Sandra, Forastiere, Francesco, Corbo, Giuseppe M., Ferro, Salvatore, Renzoni, Elisabetta, Sestini, Piersante, Rusconi, Franca, Ciccone, Gianni, Viegi, Giovanni, Chellini, Elisabetta, and Piffer, Silvano

Published
1999

21. Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis

Author

Elhakeem, Ahmed, primary, Taylor, Amy E, additional, Inskip, Hazel M, additional, Huang, Jonathan Y, additional, Mansell, Toby, additional, Rodrigues, Carina, additional, Asta, Federica, additional, Blaauwendraad, Sophia M, additional, Håberg, Siri E, additional, Halliday, Jane, additional, Harskamp-van Ginkel, Margreet W, additional, He, Jian-Rong, additional, Jaddoe, Vincent W V, additional, Lewis, Sharon, additional, Maher, Gillian M, additional, Manios, Yannis, additional, McCarthy, Fergus P, additional, Reiss, Irwin K M, additional, Rusconi, Franca, additional, Salika, Theodosia, additional, Tafflet, Muriel, additional, Qiu, Xiu, additional, Åsvold, Bjørn O, additional, Burgner, David, additional, Chan, Jerry K Y, additional, Gagliardi, Luigi, additional, Gaillard, Romy, additional, Heude, Barbara, additional, Magnus, Maria C, additional, Moschonis, George, additional, Murray, Deirdre, additional, Nelson, Scott M, additional, Porta, Daniela, additional, Saffery, Richard, additional, Barros, Henrique, additional, Eriksson, Johan G, additional, Vrijkotte, Tanja G M, additional, and Lawlor, Deborah A, additional

Published
2023
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22. Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Author

Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J., Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H., Melén, Erik, Murray, Clare S., Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C., Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W., Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A., Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G., Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke-Hilse, Mahler, Vera, Schoos, Ann Marie M., Nagakumar, Prasad, Negus, Jenny, Nielsen, Hanna, Pijnenburg, Mariëlle, Ramiconi, Valeria, Romagosa Vilarnau, Sofia, Principe, Stefania, Rutjes, Niels W. P., Saglani, Sejal, Seddon, Paul C, Singer, Florian, Staudinger, Heribert, Turner, Steve, Vijverberg, Susanne J, Winders, Tonya, Yasinska, Valentyna, Roberts, Graham, Sverrild, Asger, Lapperre, Therese, Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J., Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H., Melén, Erik, Murray, Clare S., Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C., Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W., Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A., Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G., Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke-Hilse, Mahler, Vera, Schoos, Ann Marie M., Nagakumar, Prasad, Negus, Jenny, Nielsen, Hanna, Pijnenburg, Mariëlle, Ramiconi, Valeria, Romagosa Vilarnau, Sofia, Principe, Stefania, Rutjes, Niels W. P., Saglani, Sejal, Seddon, Paul C, Singer, Florian, Staudinger, Heribert, Turner, Steve, Vijverberg, Susanne J, Winders, Tonya, Yasinska, Valentyna, Roberts, Graham, Sverrild, Asger, and Lapperre, Therese

Abstract

Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies. Methods COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult and paediatric clinicians, pharmaceutical representatives, and health regulators from across Europe. Evidence included a systematic review of development, validity and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria. Results Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z-scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire and Asthma Control Test or Childhood Asthma Control Test, while the adult COM set includes the Severe Asthma Questionnaire and Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately). Conclusions This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma., Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies. Methods COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult and paediatric clinicians, pharmaceutical representatives, and health regulators from across Europe. Evidence included a systematic review of development, validity and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria. Results Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z-scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire and Asthma Control Test or Childhood Asthma Control Test, while the adult COM set includes the Severe Asthma Questionnaire and Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately). Conclusions This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.

Published
2023

23. Long-term cardiometabolic health in people born after assisted reproductive technology:a multi-cohort analysis

Author

Elhakeem, Ahmed, Taylor, Amy E., Inskip, Hazel M., Huang, Jonathan Y., Mansell, Toby, Rodrigues, Carina, Asta, Federica, Blaauwendraad, Sophia M., Håberg, Siri E., Halliday, Jane, Harskamp-van Ginkel, Margreet W., He, Jian Rong, Jaddoe, Vincent W.V., Lewis, Sharon, Maher, Gillian M., Manios, Yannis, McCarthy, Fergus P., Reiss, Irwin K.M., Rusconi, Franca, Salika, Theodosia, Tafflet, Muriel, Qiu, Xiu, Åsvold, Bjørn O., Burgner, David, Chan, Jerry K.Y., Gagliardi, Luigi, Gaillard, Romy, Heude, Barbara, Magnus, Maria C., Moschonis, George, Murray, Deirdre, Nelson, Scott M., Porta, Daniela, Saffery, Richard, Barros, Henrique, Eriksson, Johan G., Vrijkotte, Tanja G.M., Lawlor, Deborah A., Elhakeem, Ahmed, Taylor, Amy E., Inskip, Hazel M., Huang, Jonathan Y., Mansell, Toby, Rodrigues, Carina, Asta, Federica, Blaauwendraad, Sophia M., Håberg, Siri E., Halliday, Jane, Harskamp-van Ginkel, Margreet W., He, Jian Rong, Jaddoe, Vincent W.V., Lewis, Sharon, Maher, Gillian M., Manios, Yannis, McCarthy, Fergus P., Reiss, Irwin K.M., Rusconi, Franca, Salika, Theodosia, Tafflet, Muriel, Qiu, Xiu, Åsvold, Bjørn O., Burgner, David, Chan, Jerry K.Y., Gagliardi, Luigi, Gaillard, Romy, Heude, Barbara, Magnus, Maria C., Moschonis, George, Murray, Deirdre, Nelson, Scott M., Porta, Daniela, Saffery, Richard, Barros, Henrique, Eriksson, Johan G., Vrijkotte, Tanja G.M., and Lawlor, Deborah A.

Abstract

AIMS: To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. METHODS AND RESULTS: Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (-0.53 mmHg; 95% CI:-1.59 to 0.53), DBP (-0.24 mmHg; -0.83 to 0.35), or HR (0.02 beat/min; -0.91 to 0.94). Total cholesterol (2.59%; 0.10-5.07), HDL cholesterol (4.16%; 2.52-5.81), LDL cholesterol (4.95%; 0.47-9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant. CONCLUSION: These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.

Published
2023

24. Definitions of non-response and response to biological therapy for severe asthma: a systematic review

Author

Khaleva, Ekaterina, primary, Rattu, Anna, additional, Brightling, Chris, additional, Bush, Andrew, additional, Bourdin, Arnaud, additional, Bossios, Apostolos, additional, Chung, Kian Fan, additional, Chaudhuri, Rekha, additional, Coleman, Courtney, additional, Djukanovic, Ratko, additional, Dahlén, Sven-Erik, additional, Exley, Andrew, additional, Fleming, Louise, additional, Fowler, Stephen J., additional, Gupta, Atul, additional, Hamelmann, Eckard, additional, Koppelman, Gerard H., additional, Melén, Erik, additional, Mahler, Vera, additional, Seddon, Paul, additional, Singer, Florian, additional, Porsbjerg, Celeste, additional, Ramiconi, Valeria, additional, Rusconi, Franca, additional, Yasinska, Valentyna, additional, and Roberts, Graham, additional

Published
2023
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25. Identifying and appraising outcome measures for severe asthma: a systematic review

Author

Rattu, Anna, primary, Khaleva, Ekaterina, additional, Brightling, Chris, additional, Dahlén, Sven-Erik, additional, Bossios, Apostolos, additional, Fleming, Louise, additional, Chung, Kian Fan, additional, Melén, Erik, additional, Djukanovic, Ratko, additional, Chaudhuri, Rekha, additional, Exley, Andrew, additional, Koppelman, Gerard H., additional, Bourdin, Arnaud, additional, Rusconi, Franca, additional, Porsbjerg, Celeste, additional, Coleman, Courtney, additional, Williams, Clare, additional, Nielsen, Hanna, additional, Davin, Elizabeth, additional, Taverner, Phil, additional, Romagosa Vilarnau, Sofia, additional, and Roberts, Graham, additional

Published
2022
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27. Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Author

Khaleva, Ekaterina, Rattu, Anna, Brightling, Chris, Bush, Andrew, Bossios, Apostolos, Bourdin, Arnaud, Chung, Kian Fan, Chaudhuri, Rekha, Coleman, Courtney, Dahlén, Sven-Erik, Djukanovic, Ratko, Deschildre, Antoine, Fleming, Louise, Fowler, Stephen J, Gupta, Atul, Hamelmann, Eckard, Hashimoto, Simone, Hedlin, Gunilla, Koppelman, Gerard H, Melén, Erik, Murray, Clare S, Pilette, Charles, Porsbjerg, Celeste, Pike, Katharine C, Rusconi, Franca, Williams, Clare, Ahrens, Birgit, Alter, Peter, Anckers, Freja, van den Berge, Maarten, Blumchen, Katharina, Brusselle, Guy, Clarke, Graham W, Cunoosamy, Danen, Dahlén, Barbro, Dixey, Piers, Exley, Andrew, Frey, Urs, Gaillard, Erol A, Giovannini-Chami, Lisa, Grigg, Jonathan, Hartenstein, Diana, Heaney, Liam G, Karadag, Bülent, Kaul, Susanne, Kull, Inger, Licari, Amelia, Maitland-van der Zee, Anke H, Mahler, Vera, and Roberts, Graham

Abstract

BACKGROUND: Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) working group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies.METHODS: COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult, and paediatric clinicians, pharmaceutical representatives and health regulators from across Europe. Evidence included a systematic review of development, validity, and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients' and carers' views about outcome measures. It was discussed using a modified GRADE Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria.RESULTS: Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire, and Asthma Control Test (ACT) or Childhood-ACT while the adult COM includes the Severe Asthma Questionnaire and the Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately).CONCLUSIONS: This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma.

Published
2022

28. Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Author

Khaleva, Ekaterina, primary, Rattu, Anna, additional, Brightling, Chris, additional, Bush, Andrew, additional, Bossios, Apostolos, additional, Bourdin, Arnaud, additional, Chung, Kian Fan, additional, Chaudhuri, Rekha, additional, Coleman, Courtney, additional, Dahlén, Sven-Erik, additional, Djukanovic, Ratko, additional, Deschildre, Antoine, additional, Fleming, Louise, additional, Fowler, Stephen J., additional, Gupta, Atul, additional, Hamelmann, Eckard, additional, Hashimoto, Simone, additional, Hedlin, Gunilla, additional, Koppelman, Gerard H., additional, Melén, Erik, additional, Murray, Clare S., additional, Pilette, Charles, additional, Porsbjerg, Celeste, additional, Pike, Katharine C., additional, Rusconi, Franca, additional, Williams, Clare, additional, Ahrens, Birgit, additional, Alter, Peter, additional, Anckers, Freja, additional, van den Berge, Maarten, additional, Blumchen, Katharina, additional, Brusselle, Guy, additional, Clarke, Graham W., additional, Cunoosamy, Danen, additional, Dahlén, Barbro, additional, Dixey, Piers, additional, Exley, Andrew, additional, Frey, Urs, additional, Gaillard, Erol A., additional, Giovannini-Chami, Lisa, additional, Grigg, Jonathan, additional, Hartenstein, Diana, additional, Heaney, Liam G., additional, Karadag, Bülent, additional, Kaul, Susanne, additional, Kull, Inger, additional, Licari, Amelia, additional, Maitland-van der Zee, Anke H., additional, Mahler, Vera, additional, Schoos, Ann-Marie M., additional, Nagakumar, Prasad, additional, Negus, Jenny, additional, Nielsen, Hanna, additional, Paton, James, additional, Pijnenburg, Mariëlle, additional, Ramiconi, Valeria, additional, Romagosa Vilarnau, Sofia, additional, Principe, Stefania, additional, Rutjes, Niels, additional, Saglani, Sejal, additional, Seddon, Paul, additional, Singer, Florian, additional, Staudinger, Heribert, additional, Turner, Steve, additional, Vijverberg, Susanne, additional, Winders, Tonya, additional, Yasinska, Valentyna, additional, and Roberts, Graham, additional

Published
2022
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33. Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood

Author

Elhakeem, Ahmed, Taylor, Amy E., Inskip, Hazel M., Huang, Jonathan, Tafflet, Muriel, Vinther, Johan L., Asta, Federica, Erkamp, Jan S., Gagliardi, Luigi, Guerlich, Kathrin, Halliday, Jane, Harskamp-van Ginkel, Margreet W., He, Jian-Rong, Jaddoe, Vincent W. V., Lewis, Sharon, Maher, Gillian M., Manios, Yannis, Mansell, Toby, McCarthy, Fergus P., McDonald, Sheila W., Medda, Emanuela, Nisticò, Lorenza, de Moira, Angela Pinot, Popovic, Maja, Reiss, Irwin K. M., Rodrigues, Carina, Salika, Theodosia, Smith, Ash, Stazi, Maria A., Walker, Caroline, Wu, Muci, Åsvold, Bjørn O., Barros, Henrique, Brescianini, Sonia, Burgner, David, Chan, Jerry K. Y., Charles, Marie-Aline, Eriksson, Johan G., Gaillard, Romy, Grote, Veit, Håberg, Siri E., Heude, Barbara, Koletzko, Berthold, Morton, Susan, Moschonis, George, Murray, Deirdre, O’Mahony, Desmond, Porta, Daniela, Qiu, Xiu, Richiardi, Lorenzo, Rusconi, Franca, Saffery, Richard, Tough, Suzanne C., Vrijkotte, Tanja G. M., Nelson, Scott M., Nybo Andersen, Anne-Marie, Magnus, Maria C., Lawlor, Deborah A., Clinicum, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, University of Helsinki, Public and occupational health, APH - Health Behaviors & Chronic Diseases, APH - Methodology, ARD - Amsterdam Reproduction and Development, APH - Aging & Later Life, and Pediatrics

Subjects
Adult, Male, Reproductive Techniques, Assisted, Adolescent, CHILDHOOD, EMBRYO-TRANSFER, FRESH, INFERTILITY, Cohort Studies, Reproductive Techniques, Pregnancy, Semen, Child, Child, Preschool, Embryo Transfer, Female, Humans, Infant, Obesity, Adiposity, Preschool, Embryo Transfer/methods, Uncategorized, OUTCOMES, BORN, Reproductive Techniques, Assisted/adverse effects, General Medicine, Obesity/epidemiology, Assisted, 3121 General medicine, internal medicine and other clinical medicine, HEALTH, IN-VITRO FERTILIZATION
Abstract

IMPORTANCE People conceived using assisted reproductive technology (ART) make up anincreasing proportion of the world’s population.OBJECTIVE To investigate the association of ART conception with offspring growth and adiposityfrom infancy to early adulthood in a large multicohort study.DESIGN, SETTING, AND PARTICIPANTS This cohort study used a prespecified coordinated analysisacross 26 European, Asia-Pacific, and North American population-based cohort studies that includedpeople born between 1984 and 2018, with mean ages at assessment of growth and adiposityoutcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 andFebruary 2022.EXPOSURES Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, andembryo transfer) vs natural conception (NC; without any medically assisted reproduction).MAIN OUTCOMES AND MEASURES The main outcomes were length / height, weight, and bodymass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohortwas analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, andethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13age groups.RESULTS Up to 158 066 offspring (4329 conceived by ART) were included in each age-group metaanalysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who wereNC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence,with differences largest at the youngest ages and attenuating with older child age. For example,adjusted mean differences in offspring weight were −0.27 (95% CI, −0.39 to −0.16) SD units at ageyounger than 3 months, −0.16 (95% CI, −0.22 to −0.09) SD units at age 17 to 23 months, −0.07 (95%CI, −0.10 to −0.04) SD units at age 6 to 9 years, and −0.02 (95% CI, −0.15 to 0.12) SD units at age 14to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryotransfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was −0.14[95% CI, −0.20 to −0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, −0.15 to 0.15SD units for frozen embryo transfer vs NC). More marked differences were seen for body fatmeasurements, and there was imprecise evidence that offspring conceived by ART developedgreater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17years: 0.23 [95% CI, −0.04 to 0.50] SD units).CONCLUSIONS AND RELEVANCE These findings suggest that people conceiving or conceived byART can be reassured that differences in early growth and adiposity are small and no longer evidentby late adolescence

Published
2022

34. Five-minute Apgar score and outcomes in neonates of 24-28 weeks' gestation

Author

Shah, Prakesh S, Norman, Mikael, Rusconi, Franca, Kusuda, Satoshi, Reichman, Brian, Battin, Malcolm, Bassler, Dirk, Modi, Neena, Hakansson, Stellan, Yang, Jie, Lee, Shoo K, Helenius, Kjell, Vento, Maximo, Lehtonen, Liisa, Adams, Mark, Isayama, Tetsuya, Lui, Kei, Gagliardi, Luigi, and University of Zurich

Subjects
610 Medicine & health, 10027 Clinic for Neonatology
Published
2022

36. Five-minute Apgar score and outcomes in neonates of 24-28 weeks' gestation

Author

Shah, Prakesh S., Norman, Mikael, Rusconi, Franca, Kusuda, Satoshi, Reichman, Brian, Battin, Malcolm, Bassler, Dirk, Modi, Neena, Håkansson, Stellan, Yang, Jie, Lee, Shoo K., Helenius, Kjell, Vento, Maximo, Lehtonen, Liisa, Adams, Mark, Isayama, Tetsuya, Lui, Kei, Gagliardi, Luigi, Shah, Prakesh S., Norman, Mikael, Rusconi, Franca, Kusuda, Satoshi, Reichman, Brian, Battin, Malcolm, Bassler, Dirk, Modi, Neena, Håkansson, Stellan, Yang, Jie, Lee, Shoo K., Helenius, Kjell, Vento, Maximo, Lehtonen, Liisa, Adams, Mark, Isayama, Tetsuya, Lui, Kei, and Gagliardi, Luigi

Abstract

OBJECTIVES: To assess associations between 5 min Apgar score and mortality and severe neurological injury (SNI) and to report test characteristics in preterm neonates. DESIGN, SETTING AND PATIENTS: Retrospective cohort study of neonates 240 to 286 weeks' gestation born between 2007 and 2016 and admitted to neonatal units in 11 high-income countries. EXPOSURE: 5 min Apgar score. MAIN OUTCOME MEASURES: In-hospital mortality and SNI defined as grade 3 or 4 periventricular/intraventricular haemorrhage or periventricular leukomalacia. Outcome rates were calculated for each Apgar score and compared after adjustment. The diagnostic characteristics and ORs for each value from 0 versus 1-10 to 0-9 versus 10, with 1-point increments were calculated. RESULTS: Among 92 412 included neonates, as 5 min Apgar score increased from 0 to 10, mortality decreased from 60% to 8%. However, no clear increasing or decreasing pattern was identified for SNI. There was an increase in sensitivity and decrease in specificity for both mortality and SNI associated with increasing scores. The Apgar score alone had an area under the curve of 0.64 for predicting mortality, which increased to 0.73 with the addition of gestational age. CONCLUSIONS: In neonates of 24-28 weeks' gestation admitted to neonatal units, higher 5 min Apgar score was associated with lower mortality in a graded manner, while the association with SNI remained relatively constant at all scores. Among survivors, low Apgar scores did not predict SNI.

Published
2022
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38. Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts

Author

Rusconi, Franca, Zugna, Daniela, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Correia, Sofia, Duijts, Liesbeth, Forastiere, Francesco, Inskip, Hazel, Kelleher, Cecily C., Larsen, Pernille S., Mommers, Monique, Andersen, Anne-Marie Nybo, Penders, John, Pike, Katharine, Porta, Daniela, Sonnenschein-van der Voort, Agnes, Sunyer, Jordi, Torrent, Maties, Viljoen, Karien, Vrijheid, Martine, Richiardi, Lorenzo, and Galassi, Claudia

Published
2017
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39. Scoping review shows wide variation in the definitions of bronchopulmonary dysplasia in preterm infants and calls for a consensus

Author

Hines, Delaney, Modi, Neena, Lee, Shoo K., Isayama, Tetsuya, Sjörs, Gunnar, Gagliardi, Luigi, Lehtonen, Liisa, Vento, Maximo, Kusuda, Satoshi, Bassler, Dirk, Mori, Rintaro, Reichman, Brian, Håkansson, Stellan, Darlow, Brian A., Adams, Mark, Rusconi, Franca, San Feliciano, Laura, Lui, Kei, Morisaki, Naho, Musrap, Natasha, and Shah, Prakesh S.

Published
2017
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40. Area‐based study identifies risk factors associated with missed antenatal corticosteroid prophylaxis in women delivering preterm infants

Author

Gagliardi, Luigi, Amador, Carolina, Puglia, Monia, Mecacci, Federico, Pratesi, Simone, Sigali, Emilio, Tomasini, Barbara, Rusconi, Franca, Banchini, Roberto, Papi, Maria Celeste, Pecori, Debora, Dani, Carlo, Ingargiola, Anna, Moroni, Marco, Fiorini, Patrizio, Vuerich, Marco, Santarlasci, Sara, Boldrini, Antonio, Dilucia, Sofia, Panariello, Giorgio, Vinciguerra, Filomena, Giovannoni, Armando, Dolfi, Pina, Moschetti, Riccardo, Tognetti, Simona, Capuzzo, Leila, Magnanensi, Stefania, Mariotti, Paola, Brioschi, Alessandra, Martelli, Elena, Vasarri, Pier Luigi, Carlotti, Carla, Danieli, Roberto, Gragnani, Samuele, Benetti, Gian Luca, Tiezzi, Monica, Civitelli, Flavio, Magi, Letizia, Martini, Marco, Cardinale, Antonio, Magni, Carla, Bini, Rita, De Filippo, Marcello, Cafaggi, Leonardo, Bosi, Cristiana, Gambi, Beatrice, Pezzati, Marco, Strano, Massimo, Bartoli, Ambra, Gabrielli, Paolo, Verucci, Elena, Berni, Roberto, Corsi, Andrea, and Voller, Fabio

Published
2017
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41. Pregnancy outcomes in Italy during COVID‐19 pandemic: A population‐based cohort study.

Author

Rusconi, Franca, Puglia, Monia, Pacifici, Martina, Brescianini, Sonia, Gagliardi, Luigi, Nannavecchia, Anna Maria, Buono, Pietro, Cantoira, Sara, Farchi, Sara, Gobbato, Michele, Pellegrini, Edda, Perrone, Enrica, Pertile, Riccardo, Tavormina, Elisa Eleonora, Visonà Dalla Pozza, Laura, Zambri, Francesca, Corsi, Edoardo, Formisano, Debora, Leoni, Olivia, and Mazzucato, Monica

Subjects
*PREGNANCY outcomes, *COVID-19 pandemic, *STILLBIRTH, *TIME series analysis, *COHORT analysis
Abstract

Objective: To compare the estimates of preterm birth (PTB; 22–36 weeks' gestational age, GA) and stillbirth rates during COVID‐19 pandemic in Italy with those recorded in the three previous years. Design: A population‐based cohort study of live‐ and stillborn infants was conducted using data from Regional Health Systems and comparing the pandemic period (1 March 2020–31 March 2021, n = 362 129) to an historical period (January 2017–February 2020, n = 1 117 172). The cohort covered 84.3% of the births in Italy. Methods: Poisson regressions were run in each Region and meta‐analyses were performed centrally. We used an interrupted time series regression analysis to study the trend of preterm births from 2017 to 2021. Main outcome measures: The primary outcomes were PTB and stillbirths. Secondary outcomes were late PTB (32–36 weeks' GA), very PTB (<32 weeks' GA), and extremely PTB (<28 weeks' GA), overall and stratified into singleton and multiples. Results: The pandemic period compared with the historical one was associated with a reduced risk for PTB (risk ratio [RR] 0.91, 95% confidence interval [CI] 0.88–0.93), late PTB (RR 0.91, 95% CI 0.88–0.94), very PTB (RR 0.88, 95% CI 0.84–0.91) and extremely PTB (RR 0.88, 95% CI 0.82–0.95). In multiples, point estimates were not very different, but had wider CIs. No association was found for stillbirths (RR 1.01, 95% CI 0.90–1.13). A linear decreasing trend in PTB rate was present in the historical period, with a further reduction after the lockdown. Conclusions: We demonstrated a decrease in PTB rate after the introduction of COVID‐19 restriction measures, without an increase in stillbirths. Linked article: This article is commented on by Giovanni Sisti and Julie T. Joseph, pp. 285 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17312 [ABSTRACT FROM AUTHOR]

Published
2023
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42. Early factors associated with risk of developmental coordination disorder in very preterm children: A prospective area‐based cohort study in Italy

Author

Zoia, Stefania, primary, Biancotto, Marina, additional, Caravale, Barbara, additional, Valletti, Alessandra, additional, Montelisciani, Laura, additional, Croci, Ileana, additional, Voller, Fabio, additional, Rusconi, Franca, additional, Carrozzi, Marco, additional, Chiandotto, Valeria, additional, Di Lallo, Domenico, additional, Vicari, Stefano, additional, and Cuttini, Marina, additional

Published
2022
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43. Pregnancy outcomes in Italy during COVID-19 pandemic: a population-based cohort study.

Author

Rusconi, Franca, primary, Puglia, Monia, additional, Pacifici, Martina, additional, Brescianini, Sonia, additional, Gagliardi, Luigi, additional, Nannavecchia, Anna Maria, additional, Buono, Pietro, additional, Cantoira, Sara, additional, Farchi, Sara, additional, Gobbato, Michele, additional, Pellegrini, Edda, additional, Perrone, Enrica, additional, Pertile, Riccardo, additional, Tavormina, Elisa Eleonora, additional, Pozza, Laura Visonà Dalla, additional, Zambri, Francesca, additional, Corsi, Edoardo, additional, Formisano, Debora, additional, Leoni, Olivia, additional, Mazzuccato, Monica, additional, Polo, Arianna, additional, Rusciani, Raffaella, additional, and Scoppa, Alessandro, additional

Published
2022
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44. Association of assisted reproductive technology with long-term offspring cardiometabolic health: a multi-cohort study

Author

Elhakeem, Ahmed, primary, Taylor, Amy E, additional, Inskip, Hazel M, additional, Huang, Jonathan, additional, Mansell, Toby, additional, Rodrigues, Carina, additional, Asta, Federica, additional, Blaauwendraad, Sophie M, additional, Haberg, Siri E, additional, Halliday, Jane, additional, Harskamp-van Ginkel, Margreet W, additional, He, Jian-Rong, additional, Jaddoe, Vincent WV, additional, Lewis, Sharon, additional, Maher, Gillian M, additional, Manios, Yannis, additional, McCarthy, Fergus P, additional, Reiss, Irwin KM, additional, Rusconi, Franca, additional, Salika, Theodosia, additional, Tafflet, Muriel, additional, Qiu, Xiu, additional, Asvold, Bjorn O, additional, Burgner, David, additional, Chan, Jerry KY, additional, Gagliardi, Luigi, additional, Gaillard, Romy, additional, Heude, Barbara, additional, Magnus, Maria C, additional, Moschonis, George, additional, Murray, Deirdre, additional, Nelson, Scott M, additional, Porta, Daniela, additional, Saffery, Richard, additional, Barros, Henrique, additional, Eriksson, Johan G, additional, Vrijkotte, Tanja GM, additional, and Lawlor, Deborah A, additional

Published
2022
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46. Lung function at school age in infants with lower respiratory tract infections with and without wheezing: A birth cohort study

Author

Rusconi, Franca, primary, Lombardi, Enrico, additional, Spada, Elena, additional, Brescianini, Sonia, additional, Culasso, Martina, additional, Di Toro, Francesca, additional, Frassanito, Antonella, additional, Richiardi, Lorenzo, additional, Ronfani, Luca, additional, Stella, Ileana, additional, and Gagliardi, Luigi, additional

Published
2022
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47. Modifiable environmental factors predispose term infants to bronchiolitis but bronchiolitis itself predisposes to respiratory sequelae

Author

Frassanito, Antonella, primary, Nenna, Raffaella, additional, Arima, Serena, additional, Petrarca, Laura, additional, Pierangeli, Alessandra, additional, Scagnolari, Carolina, additional, Di Mattia, Greta, additional, Mancino, Enrica, additional, Matera, Luigi, additional, Porta, Daniela, additional, Rusconi, Franca, additional, and Midulla, Fabio, additional

Published
2021
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48. Five-minute Apgar score and outcomes in neonates of 24–28 weeks’ gestation

Author

Shah, Prakesh S, primary, Norman, Mikael, additional, Rusconi, Franca, additional, Kusuda, Satoshi, additional, Reichman, Brian, additional, Battin, Malcolm, additional, Bassler, Dirk, additional, Modi, Neena, additional, Hakansson, Stellan, additional, Yang, Jie, additional, Lee, Shoo K, additional, Helenius, Kjell, additional, Vento, Maximo, additional, Lehtonen, Liisa, additional, Adams, Mark, additional, Isayama, Tetsuya, additional, Lui, Kei, additional, and Gagliardi, Luigi, additional

Published
2021
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49. Lung function at school age in infants with lower respiratory tract infections with and without wheezing: a birth cohort study.

Author

Rusconi, Franca, primary, Lombardi, Enrico, additional, Spada, Elena, additional, Brescianini, Sonia, additional, Culasso, Martina, additional, Toro, Francesca Di, additional, Frassanito, Antonella, additional, Richiardi, Lorenzo, additional, Ronfani, Luca, additional, Stella, Ileana, additional, and Gagliardi, Luigi, additional

Published
2021
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50. COVID-19-like symptoms and their relation to the SARS-CoV-2 epidemic in children and adults of an Italian birth cohort

Author

Popovic, Maja, Moccia, Chiara, Isaevska, Elena, Moirano, Giovenale, Pizzi, Costanza, Zugna, Daniela, Rusconi, Franca, Merletti, Franco, Maule, Milena, and Richiardi, Lorenzo

Subjects
Adult, NINFEA, SARS-CoV-2, COVID-19, symptoms, Italy, cohort, COVID-19 Testing, Child, Cross-Sectional Studies, Humans, Patient Discharge, Asbestos
Abstract

to estimate the population prevalence of COVID-19-like symptoms in children and adults during the first SARS-CoV-2 epidemic wave hitting Italy in the spring 2020; to assess their geographical correlation with the cumulative number of COVID-19 cases by province; to analyse their clustering within families; to estimate their sensitivity, positive predictive value (PPV) and negative predictive value (NPV) for COVID-19 diagnosis in individuals tested for SARS-CoV-2.cross-sectional study nested within a birth cohort.mothers participating in an Italian birth cohort (NINFEA) were invited to complete an online questionnaire on COVID-19-like symptoms in their household.population prevalence of COVID-19-like symptoms in children and adults, geographical correlation of COVID-19-like symptoms with the cumulative number of COVID-19 cases by province, clustering of COVID-19-like symptoms within families, and sensitivity, PPV and NPV of COVID-19-like symptoms for COVID-19 diagnosis in individuals tested for SARS-CoV-2.information was collected on 3,184 households, 6,133 adults, and 5,751 children. In the period March-April 2020, 55.4% of the NINFEA families had at least one member with at least one COVID-19-like symptom. There was a strong geographical correlation between the population cumulative incidence of COVID-19 and the prevalence of muscle pain, fatigue, low-grade fever, and breathing difficulties in adults (Spearman's rho=0.70). Having at least one family member with a COVID-19 diagnosis, compared with none tested for SARS-CoV-2, was associated with an increased prevalence ratio (PR) of almost all COVID-19-like symptoms in adults, and only of low-grade fever (37-37.5°C; PR 4.54; 95%CI 2.20-9.40) and anosmia/dysgeusia in children. Among adults with COVID-19 diagnosis, fatigue, muscle pain, and fever had a sensitivity=70%. In individuals tested for SARS-CoV-2, with a 16.6% prevalence of COVID-19, breathing difficulties and nausea/vomiting had the highest PPVs, with point estimates close to 60%, and with NPVs close to 90%.the geographical prevalence of COVID-19-like symptoms in adults may inform on local disease clusters, while certain symptoms in family members of confirmed COVID-19 cases could help identify the intra-familial spread of the virus and its further propagation in the community. Low-grade fever is frequent in children with at least one household member with COVID-19 and possibly indicates child infection.

Published
2021

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