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18 results on '"Runyon, J. Ray"'

7. LCMS Measurement of Steroid Biomarkers Collected from Palmar Sweat

Author

Runyon, J. Ray, Hyde, Jacob N., Staroschak, Christina, Kromenacker, Bryan, Wilson, Robert C., and Sternberg, Esther M.

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Palmar sweat, Eccrine sweat, precision medicine, Physiology, surface capture, eccrine sweat, sweat biomarkers, Article, non-invasive measurement, SWEAT, Physical stress, Medicine, OIF/OEF/OND, business, Palmar surface
Abstract

Human eccrine sweat contains numerous biomarkers which can provide information on health,performance, and aging. Non-invasive collection and measurement of biomarkers has becomeespecially important in recent times given viral outbreaks like SARS-CoV-2. In the current studywe describe a method of sweat collection from palmar surfaces in participants via surface captureusing glass beads and the resulting analysis of biomarkers from very low volumes of sweat usingliquid chromatography mass spectrometry with selected ion monitoring. Study participantsunderwent a cognitive and physical stress task with easy and hard conditions with sweat beingcollected after each task. Resulting analysis found a signal for 22 steroid biomarkers and wereport detailed information on selected biomarkers, given their applicability to timely real-worldexemplars, including cortisol, dehydroepiandrosterone, allopregnanolone, estrone, aldosterone,and 20a/b-dihydrocortisone.

Published
2020

16. Preparation of Narrow Dispersity Gold Nanorods by Asymmetrical Flow Field-Flow Fractionation and Investigation of Surface Plasmon Resonance.

Author

Runyon, J. Ray, Goering, Adam, Ken-Tye Yong, and Williams, S. Kim Ratanathanawongs

Subjects
*NANORODS, *GOLD, *FIELD-flow fractionation, *SURFACE plasmon resonance, *OPTICAL properties of nanorods, *NANORODS spectra, *NANOPARTICLES
Abstract

The development of an asymmetrical field-flow fractionation (AsFIFFF) method for separating gold nanorods (GNR) is reported. Collected fractions containing GNR subpopulations with aspect ratios, sizes, and shapes which are more narrowly dispersed than the original population were further characterized by UV-vis apectroscopy and transmission electron microscopy. This ability to obtain different sizes and shapes of nanoparticles enabled the evaluation of a new approach to estimating the retention time and hydrodynamic size of nanorods and the investigation of GNR optical properties at a previously unattainable level of detail. Experimental results demonstrate that the longitudinal surface plasmon absorption maximum of GNRS is correlated with the effective particle radius in addition to the aspect ratio. This may account for some of the variabilities reported in published empirical data from different research groups and supports reports of simulated absorption spectra of GNRs of different physical dimensions. The use of AsFIEFF with dual UV-vis detection to rapidly assess relative changes in GNP. subpopulations was demonstrated for irregularly shaped gold nanoparticles formed at different synthesis temperatures. [ABSTRACT FROM AUTHOR]

Published
2013
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17. Field-Flow Fractionation: Addressing the Nano Challenge.

Author

Williams, S. Kim Ratanathanawongs, Runyon, J. Ray, and Ashames, Akram A.

Subjects
*FIELD-flow fractionation, *SEPARATION (Technology), *MACROMOLECULES, *NANOPARTICLES, *NANOCHEMISTRY, *MOLECULAR weights, *MAGNETIC susceptibility
Abstract

The article focuses on the application of field-flow fractionation (FFF) to analyze nanometer-sized materials and complex components, a technique designed to separate and characterize macromolecules, particulates, and nanoparticles. It states that FFF separation is necessary to evaluate nano-sized analytes due to the continuous distribution and properties of sample components. It adds that FFF considers several factors including the samples' molecular weight, size, and magnetic susceptibility.

Published
2011
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18. LCMS Measurement of Steroid Biomarkers Collected from Palmar Sweat.

Author

Runyon JR, Hyde JN, Staroschak C, Kromenacker B, Wilson RC, and Sternberg EM

Abstract

Human eccrine sweat contains numerous biomarkers which can provide information on health, performance, and aging. Non-invasive collection and measurement of biomarkers has become especially important in recent times given viral outbreaks like SARS-CoV-2. In the current study we describe a method of sweat collection from palmar surfaces in participants via surface capture using glass beads and the resulting analysis of biomarkers from very low volumes of sweat using liquid chromatography mass spectrometry with selected ion monitoring. Study participants underwent a cognitive and physical stress task with easy and hard conditions with sweat being collected after each task. Resulting analysis found a signal for 22 steroid biomarkers and we report detailed information on selected biomarkers, given their applicability to timely real-world exemplars, including cortisol, dehydroepiandrosterone, allopregnanolone, estrone, aldosterone, and 20α/β-dihydrocortisone.

Published
2020
Full Text
View/download PDF

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