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2. The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers

Author

Gasca-Capote, Carmen, Lian, Xiaodong, Gao, Ce, Roseto, Isabelle C., Jimenez- Leon, Maria Reyes, Gladkov, Gregory, Camacho-Sojo, Maria Ines, Perez-Gomez, Alberto, Gallego, Isabel, Lopez- Cortes, Luis E., Bachiller, Sara, Vitalle, Joana, Benhnia, Mohamed Rafii-El-Idrissi, Ostos, Francisco J., Collado-Romacho, Antonio R., Santos, Jesus, Palacios, Rosario, Gomez-Ayerbe, Cristina, Munoz-Medina, Leopoldo, Ruiz-Sancho, Andres, Frias, Mario, Rivero-Juarez, Antonio, Roca-Oporto, Cristina, Hidalgo-Tenorio, Carmen, Rull, Anna, Olalla, Julian, Lopez- Ruz, Miguel A., Vidal, Francesc, Vilades, Consuelo, Mastrangelo, Andrea, Cavassini, Matthias, Espinosa, Nuria, Perreau, Matthieu, Peraire, Joaquin, Rivero, Antonio, Lopez-Cortes, Luis F., Lichterfeld, Mathias, Yu, Xu G., and Ruiz-Mateos, Ezequiel

Subjects
HIV (Viruses) -- Development and progression -- Genetic aspects -- Control, Genes -- Comparative analysis -- Genetic aspects, Antiviral agents -- Comparative analysis, Highly active antiretroviral therapy -- Comparative analysis, Health care industry
Abstract

BACKGROUND. Persistent controllers (PCs) maintain antiretroviral-free HIV-1 control indefinitely over time, while transient controllers (TCs) eventually lose virological control. It is essential to characterize the quality of the HIV reservoir in terms of these phenotypes in order to identify the factors that lead to HIV progression and to open new avenues toward an HIV cure. METHODS. The characterization of HIV-1 reservoir from peripheral blood mononuclear cells was performed using next- generation sequencing techniques, such as full-length individual and matched integration site proviral sequencing (FLIP-Seq; MIP-Seq). RESULTS. PCs and TCs, before losing virological control, presented significantly lower total, intact, and defective proviruses compared with those of participants on antiretroviral therapy (ART). No differences were found in total and defective proviruses between PCs and TCs. However, intact provirus levels were lower in PCs compared with TCs; indeed the intact/defective HIV-DNA ratio was significantly higher in TCs. Clonally expanded intact proviruses were found only in PCs and located in centromeric satellite DNA or zinc-finger genes, both associated with heterochromatin features. In contrast, sampled intact proviruses were located in permissive genic euchromatic positions in TCs. CONCLUSIONS. These results suggest the need for, and can give guidance to, the design of future research to identify a distinct proviral landscape that may be associated with the persistent control of HIV-1 without ART. FUNDING. Instituto de Salud Carlos III (FI17/00186, FI19/00083, MV20/00057, PI18/01532, PI19/01127 and PI22/01796), Gilead Fellowships (GLD22/00147). NIH grants AI155171, AI116228, AI078799, HL134539, DA047034, MH134823, amfAR ARCHE and the Bill and Melinda Gates Foundation., Introduction Elite controllers (ECs) represent a small subset of people living with HIV-1 (PLHIV), less than 1%, who can maintain undetectable viral load in the absence of antiretroviral therapy (ART) [...]

Published
2024
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3. Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

Author

Collins, David R, Urbach, Jonathan M, Racenet, Zachary J, Arshad, Umar, Power, Karen A, Newman, Ruchi M, Mylvaganam, Geetha H, Ly, Ngoc L, Lian, Xiaodong, Rull, Anna, Rassadkina, Yelizaveta, Yanez, Adrienne G, Peluso, Michael J, Deeks, Steven G, Vidal, Francesc, Lichterfeld, Mathias, Yu, Xu G, Gaiha, Gaurav D, Allen, Todd M, and Walker, Bruce D

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Prevention, Genetics, Sexually Transmitted Infections, Infectious Diseases, Clinical Research, HIV/AIDS, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adult, CD8-Positive T-Lymphocytes, Female, HIV Infections, Humans, Male, Middle Aged, Recurrence, Viremia, CD8(+) T cell dysfunction, HIV control, human immunology
Abstract

Spontaneous control of HIV infection has been repeatedly linked to antiviral CD8+ T cells but is not always permanent. To address mechanisms of durable and aborted control of viremia, we evaluated immunologic and virologic parameters longitudinally among 34 HIV-infected subjects with differential outcomes. Despite sustained recognition of autologous virus, HIV-specific proliferative and cytolytic T cell effector functions became selectively and intrinsically impaired prior to aborted control. Longitudinal transcriptomic profiling of functionally impaired HIV-specific CD8+ T cells revealed altered expression of genes related to activation, cytokine-mediated signaling, and cell cycle regulation, including increased expression of the antiproliferative transcription factor KLF2 but not of genes associated with canonical exhaustion. Lymphoid HIV-specific CD8+ T cells also exhibited poor functionality during aborted control relative to durable control. Our results identify selective functional impairment of HIV-specific CD8+ T cells as prognostic of impending aborted HIV control, with implications for clinical monitoring and immunotherapeutic strategies.

Published
2021

4. The persistence of low CD4/CD8 ratio in chronic HIV-infection, despite ART suppression and normal CD4 levels, is associated with pre-therapy values of inflammation and thymic function

Author

Garrido-Rodríguez, Vanesa, Bulnes-Ramos, Ángel, Olivas-Martínez, Israel, Pozo-Balado, María del Mar, Álvarez-Ríos, Ana Isabel, Gutiérrez, Félix, Izquierdo, Rebeca, García, Federico, Tiraboschi, Juan Manuel, Vera-Méndez, Francisco, Peraire, Joaquim, Rull, Anna, and Pacheco, Yolanda María

Published
2024
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6. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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7. Multiomics plasma effects of switching from triple antiretroviral regimens to dolutegravir plus lamivudine

Author

de Lazzari, Elisa, primary, Negredo, Eugenia B, additional, Domingo, Pere, additional, Tiraboschi, Juan M, additional, Ribera, Esteve, additional, Abdulghani, Nadia, additional, Alba, Verònica, additional, Fernández-Arroyo, Salvador, additional, Viladés, Consuelo, additional, Peraire, Joaquim, additional, Gatell, Jose M, additional, Blanco, Jose L, additional, Vidal, Francesc, additional, Rull, Anna, additional, and Martinez, Esteban, additional

Published
2024
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8. Epigenome-wide association study of COVID-19 severity with respiratory failure

Author

Castro de Moura, Manuel, Davalos, Veronica, Planas-Serra, Laura, Alvarez-Errico, Damiana, Arribas, Carles, Ruiz, Montserrat, Aguilera-Albesa, Sergio, Troya, Jesús, Valencia-Ramos, Juan, Vélez-Santamaria, Valentina, Rodríguez-Palmero, Agustí, Villar-Garcia, Judit, Horcajada, Juan P., Albu, Sergiu, Casasnovas, Carlos, Rull, Anna, Reverte, Laia, Dietl, Beatriz, Dalmau, David, Arranz, Maria J., Llucià-Carol, Laia, Planas, Anna M., Pérez-Tur, Jordi, Fernandez-Cadenas, Israel, Villares, Paula, Tenorio, Jair, Colobran, Roger, Martin-Nalda, Andrea, Soler-Palacin, Pere, Vidal, Francesc, Pujol, Aurora, and Esteller, Manel

Published
2021
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9. Effects of first-line antiretroviral therapy on the CD4/CD8 ratio and CD8 cell counts in CoRIS: a prospective multicentre cohort study

Author

Jarrin, Inmaculada, Moreno, Santiago, Alejos, Belén, Muñoz-Fernández, MÁngeles, Consuegra, Irene, Merino, Esperanza, García, Gema, Lirola, Ana López, García, Dácil, Asensi, Víctor, Valle, Eulalia, Rubio, Rafael, Pulido, Federico, Iribarren, José Antonio, Arrizabalaga, Julio, Gutiérrez, Félix, Masiá, Mar, Muga, Roberto, Sanvisens, Arantza, Berenguer, Juan, Vidal, Francesc, Montero, Marta, Blanco, José Ramón, López Bernarlo de Quirós, Juan Carlos, González-Garcia, Juan, Peraire, Joaquín, Arazo, Piedad, López-Aldeguer, José, Dalmau, David, Arnalich, Francisco, Rivero, Maria, Oteo, José Antonio, Sampériz, Gloria, Amengual, María José, Jaén, Angels, de los Santos, Ignacio, Repáraz, Jesús, Navarro, Gemma, Bernal, Enrique, Sanz, Jesús, Viciana, Pompeyo, García, Federico, Casado, José Luis, Del Romero, Jorge, Cano, Alfredo, Antela, Antonio, Quero, José Hernández, Riera, Melchor, Raposo, Montserrat, Santos, Jesús, Losada, Elena, Daniel, Podzamczer, Peñaranda, María, Ayerbe, Cristina Gómez, Espinosa, Nuria, Olalla, Julián, Imaz, Arkaitz, Martínez, Onofre, Curran, Adrian, Castro, Ángeles, Pérez Stachowski, Javier, Muñoz, Josefa, Vera, Francisco Jesús, Galera, Carlos, Pernas, Berta, Amador, Concha, Zuriñe, Miren, Albendin, Helena, Suárez-García, Inés, Pasquau, Francisco, Omar, Mohamed, Malmierca, Eduardo, de Zarraga, Miguel Alberto, Gómez Vidal, María Amparo, Estrada, Vicente, Górgolas, Miguel, Sanz, José, Téllez, María Jesús, Galindo, María José, Cabello, Alfonso, Rivero, Antonio, Arranz, Alberto, Cervero, Miguel, Vilalta, Ramón, Pineda, Juan A, Rivero-Juárez, Antonio, Torres, Rafael, Poveda, Eva, Rincón, Pilar, Pérez, Alexandre, Moreno, Cristina, Portilla, Irene, Díaz-Flores, Felicitas, Rivas, María E, Bisbal, Otilia, Aramburu, María J, Padilla, Sergio, Fuster, Daniel, Gutiérrez, Isabel, Viladés, Consuelo, Blanes, Marino, Arribas, José Ramón, Ibarra, Valvanera, Sanmartí, Montse, de Alda, María Ruiz, Cervantes, Manel, Salas, Ana, Dronda, Fernando, Alcaraz, Antonia, Muñoz, Leopoldo, Rodríguez, Carmen, Ribas, María Angels, Viciana, Isabel, López-Cortés, Luis, Tiraboschi, Juan, del Arco, Alfonso, Martínez, Lorena, Mena, Álvaro, Mirena, Josu, Pérez, Aurora, Ena, Javier, González-Ruano, Patricia, Vergas, Jorge, Álvarez, Beatriz, Hernández, Cristina, Ferrer, Ana, López, Pedro, Macías, Juan, Crespo, Manuel, Navarro, Maria Luisa, Iniesta, Carlos, Agea, Iván, Gómez, Juan Luis, Suárez-Zarracina, Tomás, Hernando, Asunción, Camino, Xabier, Robledano, Catalina, Ramírez, Margarita, Veloso, Sergio, Tasias, María, Bernardino, Jose Ignacio, Metola, Luis, Cairó, Mireia, de León Cano, María Teresa, Calzado, Sonia, Sarria, Cristina, Moreno, Ana, Bravo, Joaquín, Alvarez, Marta, Puerta, Teresa, Campins, Antoni A, Palacios, Rosario, Silva, Ana, de la Torre, Javier, García, Josefina, Ibarra, Sofía, Iborra, Asunción, Benito, Concha, Martín, Dolores, Pérez-Somarriba, Juncal, Prieto, Laura, Novella, María, Machuca, Isabel, Merchante, Nicolás, Morano, Luis, González, Maria Isabel, García, Luis NM, Portilla, Joaquín, Alonso, María del Mar, Pérez, Laura, Domínguez, Lourdes, Rodríguez-Arrondo, Francisco, Colomé, Joan Gregori, Padilla, Belén, Vargas, Montserrat, Castro, Iván, Castro, Juan Miguel, Sanz, Mercedes, Martinez-Lacasa, Javier, Pierola, Beatriz, Navarro, Marta, Garcia-Fraile, Lucio, Pérez-Elias, Maria Jesús, Muñoz, Ángeles, Chueca, Natalia, Carrió, Juan Carlos, Vidal, Carmen, Pérez, Carmen, Saumoy, María, Prada, José Luis, Alcaraz, Begoña, Ferrero, Oscar, Moreno, Antonio, Fenoll, Vicenta, Ruiz, Mª Pilar, Frias, Mario, Real, Luis Miguel, Miralles, Celia, Garcia, Federico, Sanz, Nieves, Sánchez-Payá, José, Pelazas, Ricardo, Rial, David, von Wichman, Miguel Ángel, Adsuar, Araceli, Gijón, Paloma, Olona, Montserrat, Calabuig, Eva, Delgado, Ana, Pérez-Martínez, Laura, Velli, Pablo, Martín-Gayo, Enrique, Gutiérrez, Carolina, Alcaraz, Maria José, Vinuesa, David, Vera, Mar, Fanjul, Francisco, Gonzalez-Domenec, Carmen, Prieto, Paula, de las Lomas, José N García, Jimeno, Amaya, López, Josefina, Merlos, Maria, Gil, Concepción, Camacho, Angela, Corma, Anais, Ocampo, Antonio, Rava, Marta, Rodríguez, Juan Carlos, Hernández, Jehovana, Bermejo, Laura, Pascual, Lidia, Pascual, Rafael, Aldamiz-Echevarría, Teresa, Rull, Anna, Cuéllar, Sandra, Escosa, Luis, Font, Roser, Madrid, Nadia, del Carmen Villalba, Maria, Martinez-Montes, Clara, Ballesteros, Juan, Murillas, Javier, Cámara, María Mar, Vidal, Asunción, Algado, José Tomas, Fernández, Marta, Pousada, Guillermo, Iribarren, Jose Antonio, Gimeno, Lina, Alemán, María Remedios, Santacreu, Mireia, Goenaga, Miguel Ángel, Tejerina, Francisco, Rodríguez-Gallego, Esther, Salavert, Miguel, Herranz, Pedro, Martinez, Marina, del Campo, Santos, Guerrero, Carlos, Ayerdi, Oskar, Homar, Francisco, de la Peña, Mireia, Meca, Marisa, Díez, Marcos, Azkune, Harkaitz, Barber, Xavier, Balsalobre, Pascual, Castellanos, Alfonso Javier, García-Bujalance, Silvia, Vivancos, Maria Jesús, Fuentes, Ana, Martin, Maria Luisa, Lopez, Iñigo, Vilchez, Helem, Lopez, Miriam, Carreres, Melissa, Ibarguren, Maialen, Agullo, Vanessa, Diez, Cristina, López-Dupla, Miguel, García, Milagros, Umerez, Maitane, Martínez-Sanz, Javier, Payeras, Antoni, Reus, Sergio, Lizardi, Aitziber, Garcia, Javier, Pérez, Leire, González-Baeza, Alicia, Anxa, Usua, González, Juan, Boix, Vicente, Kortajarena, Xabier, Pascual, Reyes, Fanciulli, Chiara, Martín-Carbonero, Maria Luz, Mellado, Maria José, Micán, Rafael, Montejano, Rocio, Montes, María Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rúa, Guadalupe, Rodés, Berta, Sainz, Talia, Sendagorta, Elena, Stella, Natalia, Valencia, Eulalia, Velasco, Tamara, Muñoz-Fernández, María Ángeles, Torrús, Diego, Carmona, María Pilar, Roca, María, Mayoral, Mario, Vallejo, Alejandro, Serrano-Villar, Sergio, Ron, Raquel, Talavera-Rodríguez, Alba, Fernández-Felix, Borja M, Herrera, Sabina, Muriel, Alfonso, de Zárraga, Miguel Alberto, and Vivancos, María J

Published
2020
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10. Multiomics plasma effects of switching from triple antiretroviral regimens to dolutegravir plus lamivudine.

Author

Lazzari, Elisa de, Negredo, Eugenia B, Domingo, Pere, Tiraboschi, Juan M, Ribera, Esteve, Abdulghani, Nadia, Alba, Verònica, Fernández-Arroyo, Salvador, Viladés, Consuelo, Peraire, Joaquim, Gatell, Jose M, Blanco, Jose L, Vidal, Francesc, Rull, Anna, and Martinez, Esteban

Subjects
LAMIVUDINE, MULTIOMICS, INSULIN-like growth factor-binding proteins, ATAZANAVIR, DOLUTEGRAVIR
Abstract

Introduction The DOLAM trial revealed that switching from triple antiretroviral therapy (three-drug regimen; 3DR) to dolutegravir plus lamivudine (two-drug regimen; 2DR) was virologically non-inferior to continuing 3DR after 48 weeks of follow-up. Weight increased with 2DR relative to 3DR but it did not impact on metabolic parameters. Methods Multiomics plasma profile was performed to gain further insight into whether this therapy switch might affect specific biological pathways. DOLAM (EudraCT 201500027435) is a Phase 4, randomized, open-label, non-inferiority trial in which virologically suppressed persons with HIV treated with 3DR were assigned (1:1) to switch to 2DR or to continue 3DR for 48 weeks. Untargeted proteomics, metabolomics and lipidomics analyses were performed at baseline and at 48 weeks. Univariate and multivariate analyses were performed to identify changes in key molecules between both therapy arms. Results Switching from 3DR to 2DR showed a multiomic impact on circulating plasma concentration of N -acetylmuramoyl-L-alanine amidase (Q96PD5), insulin-like growth factor-binding protein 3 (A6XND0), alanine and triglyceride (TG) (48:0). Correlation analyses identified an association among the up-regulation of these four molecules in persons treated with 2DR. Conclusions Untargeted multiomics profiling studies identified molecular changes potentially associated with inflammation immune pathways, and with lipid and glucose metabolism. Although these changes could be associated with potential metabolic or cardiovascular consequences, their clinical significance remains uncertain. Further work is needed to confirm these findings and to assess their long-term clinical consequences. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Martínez-Sanz, Javier, primary, Díaz-Álvarez, Jorge, additional, Rosas Cancio-Suarez, Marta, additional, Ron, Raquel, additional, Iribarren, José Antonio, additional, Bernal, Enrique, additional, Gutiérrez, Félix, additional, Ruiz Sancho, Andrés, additional, Cabello, Noemi, additional, Olalla, Julián, additional, Moreno, Santiago, additional, Serrano-Villar, Sergio, additional, Jarrín, Inma, additional, Dalmau, David, additional, Navarro, M. Luisa, additional, González, M. Isabel, additional, Garcia, Federico, additional, Poveda, Eva, additional, Iribarren, Jose Antonio, additional, Rubio, Rafael, additional, Vidal, Francesc, additional, Berenguer, Juan, additional, González, Juan, additional, Muñoz-Fernández, M. Ángeles, additional, Jarrín, Inmaculada, additional, Moreno, Cristina, additional, Rava, Marta, additional, Izquierdo, Rebeca, additional, Mauleón, Elba, additional, Portilla, Joaquín, additional, Portilla, Irene, additional, Merino, Esperanza, additional, García, Gema, additional, Agea, Iván, additional, Sánchez-Payá, José, additional, Rodríguez, Juan Carlos, additional, Giner, Livia, additional, Reus, Sergio, additional, Boix, Vicente, additional, Torrus, Diego, additional, Pérez, Verónica, additional, Portilla, Julia, additional, Gómez, Juan Luís, additional, Hernández, Jehovana, additional, Lirola, Ana López, additional, García, Dácil, additional, Díaz-Flores, Felicitas, additional, Alonso, M. Mar, additional, Pelazas, Ricardo, additional, Alemán, M. Remedios, additional, Asensi, Víctor, additional, Rivas Carmenado, María Eugenia, additional, Suarez-Zarracina, Tomás, additional, Pulido, Federico, additional, Bisbal, Otilia, additional, Hernando, M. Asunción, additional, Rial, David, additional, de Lagarde, María, additional, Arce, Octavio, additional, Pinto, Adriana, additional, Bermejo, Laura, additional, Santacreu, Mireia, additional, Navarro, Roser, additional, Gonzalez, Candela, additional, Aramburu, M. José, additional, Camino, Xabier, additional, Ángel von Wichmann, Miguel, additional, Goenaga, Miguel Ángel, additional, Bustinduy, M. Jesús, additional, Azkune, Harkaitz, additional, Ibarguren, Maialen, additional, Kortajarena, Xabier, additional, Álvarez-Rodriguez, Ignacio, additional, Gil, Leire, additional, Martínez, Lourdes, additional, Robledano, Catalina, additional, Masiá, Mar, additional, Padilla, Sergio, additional, Adsuar, Araceli, additional, Pascual, Rafael, additional, Fernández, Marta, additional, Galiana, Antonio, additional, García, José Alberto, additional, Barber, Xavier, additional, Agullo, Vanessa, additional, Abellán, Javier Garcia, additional, Pascual, Reyes, additional, Telenti, Guillermo, additional, Guillén, Lucia, additional, Botella, Ángela, additional, Muga, Roberto, additional, Sanvisens, Arantza, additional, Fuster, Daniel, additional, Gutierrez, Isabel, additional, López, Juan Carlos, additional, Ramírez, Margarita, additional, Padilla, Belén, additional, Gijón, Paloma, additional, Aldamiz-Echevarría, Teresa, additional, Tejerina, Francisco, additional, Diez, Cristina, additional, Pérez, Leire, additional, Fanciulli, Chiara, additional, Corral, Saray, additional, Martí, Anna, additional, Peraire, Joaquín, additional, Viladés, Consuelo, additional, Vargas, Montserrat, additional, Olona, Montserrat, additional, Rull, Anna, additional, Alba, Verónica, additional, Yeregui, Elena, additional, Masip, Jenifer, additional, García-Pardo, Graciano, additional, Bertomeu, Frederic Gómez, additional, Espineira, Sonia, additional, Montero, Marta, additional, Cuéllar, Sandra, additional, Blanes, Marino, additional, Tasias, María, additional, Calabuig, Eva, additional, Salavert, Miguel, additional, Fernández, Juan, additional, Segarra, Inmaculada, additional, González-García, Juan, additional, Delgado, Ana, additional, Arnalich, Francisco, additional, Arribas, José Ramón, additional, Bernardino, Jose Ignacio, additional, Castro, Juan Miguel, additional, Escosa, Luis, additional, Herranz, Pedro, additional, Hontañón, Victor, additional, García-Bujalance, Silvia, additional, García, Milagros, additional, González-Baeza, Alicia, additional, Martín-Carbonero, M. Luz, additional, Mayoral, Mario, additional, Mellado, M. Jose, additional, Esteban, Rafael, additional, Montejano, Rocío, additional, Montes, M. Luisa, additional, Moreno, Victoria, additional, Pérez-Valero, Ignacio, additional, Rodés, Berta, additional, Rúa, Guadalupe, additional, Sainz, Talía, additional, Sendagorta, Elena, additional, Valencia, Eulalia, additional, Busca, Carmen, additional, Cano, Joanna, additional, Cardiñanos, Julen, additional, de Miguel, Rosa, additional, Blanco, Jose Ramón, additional, Pérez-Martínez, Laura, additional, Oteo, José Antonio, additional, Ibarra, Valvanera, additional, Metola, Luis, additional, Sanz, Mercedes, additional, Arazo, Piedad, additional, Sampériz, Gloria, additional, Martinez, Marina, additional, Jaén, Angels, additional, Sanmartí, Montse, additional, Cairó, Mireia, additional, Martinez-Lacasa, Javier, additional, Velli, Pablo, additional, Font, Roser, additional, Xercavins, Mariona, additional, Alonso, Noemí, additional, Aiello, Francesco, additional, Rivero, María, additional, Piérola, Beatriz, additional, Goikoetxea, Maider, additional, Gracia, María, additional, Ibero, Carlos, additional, Moreno, Estela, additional, Repáraz, Jesús, additional, Navarro, Gemma, additional, Garcia, Manel Cervantes, additional, Isbert, Sonia Calzado, additional, Vilasaro, Marta Navarro, additional, Garcia, Belen Lopez, additional, Santos, Ignacio de los, additional, Santos, Alejandro de los, additional, Sanz, Jesús, additional, García-Fraile, Lucio, additional, Martín, Enrique, additional, Sánchez-Cerrillo, Ildefonso, additional, Calvet, Marta, additional, Barrios, Ana, additional, Bautista, Azucena, additional, Sáez, Carmen, additional, Ciudad, Marianela, additional, Gutiérrez, Ángela, additional, Campo, Santos del, additional, Casado, José Luis, additional, Dronda, Fernando, additional, Moreno, Ana, additional, Pérez, M. Jesús, additional, Serrano, Sergio, additional, Vivancos, Ma Jesús, additional, Martínez-Sanz, Javier, additional, Vallejo, Alejandro, additional, Sanchez, Matilde, additional, Pérez-Molina, Jose Antonio, additional, Hermida, José Manuel, additional, Alcaraz, Antonia, additional, Bravo, Joaquín, additional, Muñoz, Ángeles, additional, Tomás, Cristina, additional, Martínez, Mónica, additional, Villalba, M. Carmen, additional, García, Federico, additional, Martínez, Clara, additional, Hernández, José, additional, Medina, Leopoldo Muñoz, additional, Álvarez, Marta, additional, Chueca, Natalia, additional, Vinuesa, David, additional, de Salazar, Adolfo, additional, Fuentes, Ana, additional, Guirao, Emilio, additional, Viñuela, Laura, additional, Ruiz-Sancho, Andrés, additional, Anguita, Francisco, additional, Del Romero, Jorge, additional, Raposo, Montserrat, additional, Rodríguez, Carmen, additional, Puerta, Teresa, additional, Carrió, Juan Carlos, additional, Vera, Mar, additional, Ballesteros, Juan, additional, Ayerdi, Oskar, additional, Baza, Begoña, additional, Orviz, Eva, additional, Antela, Antonio, additional, Losada, Elena, additional, Riera, Melchor, additional, Peñaranda, María, additional, Ribas, M. Angels, additional, Campins, Antoni A., additional, Garcia-Gazalla, Mercedes, additional, Fanjul, Francisco J., additional, Murillas, Javier, additional, Homar, Francisco, additional, Vilchez, Helem H., additional, Martin, Luisa, additional, Payeras, Antoni, additional, Santos, Jesús, additional, López, María, additional, Gómez, Crisitina, additional, Viciana, Isabel, additional, Palacios, Rosario, additional, López-Cortés, Luis Fernando, additional, Espinosa, Nuria, additional, Roca, Cristina, additional, Llaves, Silvia, additional, Tiraboschi, Juan Manuel, additional, Imaz, Arkaitz, additional, Silva, Ana Karina, additional, Saumoy, María, additional, Scévola, Sofía Catalina, additional, Curran, Adrián, additional, Falcó, Vicenç, additional, Navarro, Jordi, additional, Burgos, Joaquin, additional, Suanzes, Paula, additional, García, Jorge, additional, Descalzo, Vicente, additional, Álvarez, Patricia, additional, Planas, Bibiana, additional, Sanchiz, Marta, additional, Rodríguez, Lucía, additional, Sánchez, M José, additional, Pérez, Javier, additional, Arco, Alfonso del, additional, Torre, Javier de la, additional, Prada, José Luis, additional, Martínez, Onofre Juan, additional, Martinez, Lorena, additional, Vera, Francisco Jesús, additional, García, Josefina, additional, Alcaraz, Begoña, additional, Sánchez Guirao, Antonio Jesús, additional, Mena, Alvaro, additional, Castro, Angeles, additional, Pernas, Berta, additional, Vázquez, Pilar, additional, López, Soledad, additional, Ibarra, Sofía, additional, García, Guillermo, additional, Mirena, Josu, additional, Ferrero, Oscar Luis, additional, López, Josefina, additional, Cámara, M. Mar, additional, Peña, Mireia de la, additional, Lopez, Miriam, additional, Lopez, Iñigo, additional, Lombide, Itxaso, additional, Polo, Victor, additional, de Miguel, Joana, additional, Galera, Carlos, additional, Fernández, Marian, additional, Albendin, Helena, additional, Castillo, Antonia, additional, Iborra, Asunción, additional, Moreno, Antonio, additional, Merlos, M. Angustias, additional, Vidal, Asunción, additional, Amador, Concha, additional, Pasquau, Francisco, additional, Gil, Concepcion, additional, Algado, Jose Tomás, additional, Suarez-García, Inés, additional, Malmierca, Eduardo, additional, González-Ruano, Patricia, additional, Ruiz, M. Pilar, additional, Pascual, José Francisco, additional, Sáez, Elena, additional, Balsalobre, Luz, additional, López, M. Villa, additional, Omar, Mohamed, additional, Herrero, Carmen, additional, Gómez, M. Amparo, additional, Alberto de Zarraga, Miguel, additional, Pérez, Desiré, additional, Estrada, Vicente, additional, Sanz, Nieves, additional, Cabello, Noemí, additional, García, Jorge Vergas, additional, Núñez, Maria Jose, additional, Sagastagoitia, Iñigo, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Álvarez, Beatriz, additional, Prieto, Laura, additional, Carrillo, Irene, additional, Sanz, José, additional, Arranz, Alberto, additional, Hernández, Cristina, additional, Novella, María, additional, Galindo, M. José, additional, Ferrer, Ana, additional, Román, Antonio Rivero, additional, Ruíz, Inma, additional, Juárez, Antonio Rivero, additional, López, Pedro, additional, Machuca, Isabel, additional, Frias, Mario, additional, Camacho, Ángela, additional, Pérez, Ignacio, additional, Corona, Diana, additional, Cervero, Miguel, additional, Torres, Rafael, additional, Pineda, Juan Antonio, additional, Rincón, Pilar, additional, Macías, Juan, additional, Real, Luis Miguel, additional, Corma, Anais, additional, Gonzalez-Serna, Alejandro, additional, Pérez, Alexandre, additional, Morano, Luis, additional, Miralles, Celia, additional, Ocampo, Antonio, additional, Pousada, Guillermo, additional, Patiño, Lucía, additional, Dueñas, Carlos, additional, Gutiérrez, Sara, additional, Tapia, Elena, additional, Novoa, Cristina, additional, Egües, Xjoylin, additional, and Telleria, Pablo, additional

Published
2023
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12. Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy

Author

Rodríguez-Gallego, Esther, Gómez, Josep, Domingo, Pere, Ferrando-Martínez, Sara, Peraire, Joaquim, Viladés, Consuelo, Veloso, Sergi, López-Dupla, Miguel, Beltrán-Debón, Raúl, Alba, Verónica, Vargas, Montserrat, Castellano, Alfonso J., Leal, Manuel, Pacheco, Yolanda María, Ruiz-Mateos, Ezequiel, Gutiérrez, Félix, Vidal, Francesc, and Rull, Anna

Published
2018
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13. Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV

Author

Espineira, Sonia, primary, Flores-Piñas, Marina, additional, Chafino, Silvia, additional, Viladés, Consuelo, additional, Negredo, Eugenia, additional, Fernández-Arroyo, Salvador, additional, Mallolas, Josep, additional, Villar, Beatriz, additional, Moreno, Santiago, additional, Vidal, Francesc, additional, Rull, Anna, additional, and Peraire, Joaquim, additional

Published
2023
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15. IL-7/IL-7R gene variants impact circulating IL-7/IL-7R homeostasis and ART-associated immune recovery status

Author

Ceausu, Andra, Rodríguez-Gallego, Esther, Peraire, Joaquim, López-Dupla, Miguel, Domingo, Pere, Viladés, Consuelo, Vidal-Gonzalez, Judit, Peraire, Maria, Perpiñán, Carles, Pacheco, Yolanda María, Veloso, Sergi, Alba, Verónica, Vargas, Montserrat, Castellano, Alfonso J., Ruiz-Mateos, Ezequiel, Mallolas, Josep, Vidal, Francesc, and Rull, Anna

Published
2019
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16. Transient Viral Rebound in Children with Perinatally Acquired HIV-1 Induces a Unique Soluble Immunometabolic Signature Associated with Decreased CD4/CD8 Ratio

Author

Tarancon-Diez, Laura, primary, Peraire, Joaquim, additional, Jiménez de Ory, Santiago, additional, Guirro, Maria, additional, Escosa, Luis, additional, Prieto Tato, Luis Manuel, additional, Penín Antón, María, additional, Piqueras, Ana Isabel, additional, Vázquez Pérez, Álvaro, additional, Gavilán, César, additional, Bustillo-Alonso, Matilde, additional, Navarro, María Luisa, additional, Viladés, Consuelo, additional, Vidal, Francesc, additional, Rull, Anna, additional, and Muñoz-Fernández, María Ángeles, additional

Published
2023
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19. Insatisfacción corporal y belleza en la mujer mayor. Un programa de intervención psicosocial para aumentar el bienestar y la autoestima de las mujeres

Author

Ricart Rull, Anna and Fabà Ribera, Josep

Subjects
Master's theses, Bellesa personal, Social intervention, Well-being, Autoestima, Intervenció psicològica, Intervenció social, Treballs de fi de màster, Older women, Body image, Psychological intervention, Imatge corporal, Self-esteem, Dones grans, Benestar, Personal beauty
Abstract

Màster Oficial de Psicogerontologia, Facultat de Psicologia, Universitat de Barcelona. Curs: 2021-2022. Tutor: Josep Fabà Ribera, IV Premi al millor Treball Final de Màster amb perspectiva de gènere de la Universitat de Barcelona - Rosalind Franklin - Curs: 2021-2022. Diploma de Menció Honorífica. (8 de març de 2023), [spa] Especialmente en el género femenino, existe una presión en la sociedad para encajar dentro de unos estándares de belleza poco flexibles. Los medios de comunicación son los principales promotores de estos ideales de belleza, y generan su internalización dentro de cada sociedad desde edades muy tempranas acerca de cuál es el modelo de belleza que es aceptado en cada etapa de la vida. A pesar de que se ha comprobado que esta presión es mayor en la población jóven, estos cánones siguen presentes durante el proceso de envejecimiento, lo cual provoca insatisfacción corporal. A pesar de los datos alarmantes acerca de la relación de las mujeres con su cuerpo, existen escasos programas para prevenir o intervenir en este ámbito, especialmente en el caso de las mujeres mayores. Por ello, el presente trabajo trata de una propuesta de intervención psicosocial de 9 sesiones grupales, en la que semanalmente se realizarán actividades principalmente vivenciales y de reflexión planteadas desde una perspectiva de género, con el objetivo de reducir la insatisfacción corporal de las mujeres mayores, así como la presión estética percibida, aumentando su bienestar durante el envejecimiento. A pesar de las dificultades que se puedan producir, como la gestión del alta carga emocional en alguna actividad, o limitaciones en cuanto a la adaptación de escalas para evaluar el programa, encontramos muchos beneficios también, como que se suma a la escasa oferta de programas de intervención dirigidos a esta temática y, además, utiliza actividades que se apoyan en literatura previa y que son planteadas desde distintas ópticas para alcanzar los objetivos planteados., [eng] Especially in the case of the female gender, there exists a strong pressure in society to fit into very inflexible beauty standards. The social media are the main promoters of these beauty ideals, and promote their internalization about what is the beauty model that is accepted within each society from early ages. Despite the fact that it has been proven that, currently, this pressure and its consequences are greater in young populations, these canons are still present during the aging process, in which many of the typical signs of ageing do not fit, which causes body dissatisfaction. Despite the alarming data about the relationship of women with their own body, there are few programs with the aim to prevent or intervene in this area, especially in the case of older women. For this reason, the work presents a psychosocial intervention proposal of 9 group sessions, in which mainly experiential and reflective activities will be carried out from a gender perspective, with the aim of reducing body dissatisfaction, as well as the perceived aesthetic pressure, by increasing their well being during ageing. Even with the difficulties that may occur, such as managing the high emotional load in some activity, or limitations in terms of adapting scales to our population, we can also find that our program can be added to the limited offer of intervention programs aimed at this topic, and, in addition, that uses activities that are based on previous literature and that are raised from different perspectives to achieve the stated objectives.

Published
2022

20. Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes

Author

Ceperuelo-Mallafré, Victòria, primary, Reverté, Laia, additional, Peraire, Joaquim, additional, Madeira, Ana, additional, Maymó-Masip, Elsa, additional, López-Dupla, Miguel, additional, Gutierrez-Valencia, Alicia, additional, Ruiz-Mateos, Ezequiel, additional, Buzón, Maria José, additional, Jorba, Rosa, additional, Vendrell, Joan, additional, Auguet, Teresa, additional, Olona, Montserrat, additional, Vidal, Francesc, additional, Rull, Anna, additional, and Fernández-Veledo, Sonia, additional

Published
2022
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22. A baseline metabolomic signature is associated with immunological CD4+ T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients

Author

Rodríguez-Gallego, Esther, Gómez, Josep, Pacheco, Yolanda M., Peraire, Joaquim, Viladés, Consuelo, Beltrán-Debón, Raúl, Mallol, Roger, López-Dupla, Miguel, Veloso, Sergi, Alba, Verónica, Blanco, Julià, Cañellas, Nicolau, Rull, Anna, Leal, Manuel, Correig, Xavier, Domingo, Pere, and Vidal, Francesc

Published
2018
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23. Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation

Author

Masip, Jenifer, primary, Jorba, Rosa, additional, López-Dupla, Miguel, additional, Domingo, Pere, additional, Pacheco, Yolanda María, additional, García-Pardo, Graciano, additional, Martínez, Esteban, additional, Viladés, Consuelo, additional, Veloso, Sergi, additional, Alba, Verónica, additional, Olona, Montserrat, additional, Vidal, Francesc, additional, Gómez-Bertomeu, Frederic, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2022
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24. Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients

Author

Trujillo-Rodriguez, María, primary, Muñoz-Muela, Esperanza, additional, Serna-Gallego, Ana, additional, Praena-Fernández, Juan Manuel, additional, Pérez-Gómez, Alberto, additional, Gasca-Capote, Carmen, additional, Vitallé, Joana, additional, Peraire, Joaquim, additional, Palacios-Baena, Zaira R., additional, Cabrera, Jorge Julio, additional, Ruiz-Mateos, Ezequiel, additional, Poveda, Eva, additional, López-Cortés, Luis Eduardo, additional, Rull, Anna, additional, Gutierrez-Valencia, Alicia, additional, and López-Cortés, Luis Fernando, additional

Published
2022
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25. Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Author

Masip, Jenifer, Rallón, Norma, Yeregui, Elena, Olona, Montserrat, Resino, Salvador, Benito, José Miguel, Viladés, Consuelo, García-Pardo, Graciano, Alcamí, José, Ruiz-Mateos, Ezequiel, Gómez-Bertomeu, Frederic, Vargas, Montserrat, Navarro, Marta, Oteo, José A, Pineda, Juan A, Martí, Anna, Alba, Verónica, Vidal, Francesc, Peraire, Joaquin, Rull, Anna, ECRIS integrated in the Spanish AIDS Research Network, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Red de Investigación Cooperativa en Investigación en Sida (España), Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas), Rovira i Virgili University (España), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Unión Europea. Fondo Social Europeo (ESF/FSE), Agency for Administration of University and Research, Gilead Sciences (Spain), European Commission, Generalitat de Catalunya, Gilead Research Scholars, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Institut d'Investigació Sanitària Pere Virgili, and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica

Subjects
Mass spectrometry, Immunology, HIV Infections, HIV infection, Lipids, Long-term, Lipidomics, HIV-1, Immunology and Allergy, Metabolomics, Humans, Ketoglutaric Acids, Elite controllers (ECs), Viral, Kreb's cycle, Follow-Up Studies
Abstract

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunological HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunological HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF] in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunological control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunological control (less than 5 years; no-LTEC patients). Long-term viral and immunological HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biological processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals., This work was supported by the Fondo de Investigación Sanitaria [PI13/0796, PI16/00503, PI16/0684, PI18/1532, PI19/00004, PI19/01127, PI19/01337 PI16/001769, PI19/00973, and PI20/00326]-ISCIII-FEDER (co-funded by the European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”); Programa de Suport als Grups de Recerca AGAUR (2017SGR948); Gilead Fellowship Program GLD14/293; The SPANISH AIDS Research Network [RD16/0002/0001, RD16/0002/0002, RD16/0025/0006, RD16/0025/0013, and RD16/0025/0020]-ISCIII-FEDER (Spain); and the Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII [CB21/13/00015, CB21/13/00020, and CB21/13/00044], Madrid, Spain. JM is supported by the Universitat Rovira I Virgili under grant agreement “2019PMF-PIPF-18,” through the call “Martí Franquès Research Fellowship Programme.” NR is a Miguel Servet researcher from the ISCIII [CPII19/00025]. EY is supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI20/0011800” through the program “Contratos Predoctorales de Formación en Investigación en Salud.” ER-M was supported by the Spanish National Research Council (CSIC). FV is supported by grants from the Programa de Intensificación de Investigadores (INT20/00031)-ISCIII and by “Premi a la Trajectòria Investigadora als Hospitals de l’ICS 2018.” AR is supported by IISPV through the project “2019/IISPV/05” (Boosting Young Talent), by GeSIDA through the “III Premio para Jóvenes Investigadores 2019,” and by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CP19/00146” through the Miguel Servet Program.

Published
2022

26. Migration and activation marker expressing in monocytes subset in mild and several/critical patients (S/C)

Author

Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, López-Cortés, Luis F., Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, and López-Cortés, Luis F.

Abstract

S2 Fig. Migration and activation marker expressing in monocytes subset in mild and several/critical patients (S/C).

Published
2022

27. Baseline characteristics of the mild patients who were discharged and worsened during the first week

Author

Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, López-Cortés, Luis F., Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, and López-Cortés, Luis F.

Abstract

Quantitative variables are expressing as number (percentage) or median (interquartile range). Pa value for differences between patients who were or not discharged. Pb value for differences between patients who who did and did not get wore. SpO2, peripheral capillary oxygen saturation; CRP, C-reactive protein; LDH, Lactate dehydrogenase; NLR, neutrophil/lymphocyte ratio.

Published
2022

28. Activation, homing and maturation marker expression in different monocyte subsets

Author

Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, López-Cortés, Luis F., Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, and López-Cortés, Luis F.

Abstract

Data are expressed by percentage and interquartile range. Medians fluorescence intensitive (MFI) were calculated in those markets that have a high rate of expression.

Published
2022

29. S1 Fig - Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients

Author

Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, López-Cortés, Luis F., Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Serna, Ana, Praena-Segovia, Julia, Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Peraire, Joaquim, Palacios-Baena, Zaira Raquel, Cabrera-Alvar, Jorge Julio, Ruiz-Mateos, Ezequiel, Poveda, Eva, López-Cortés, Luis Eduardo, Rull, Anna, Gutiérrez Valencia, Alicia, and López-Cortés, Luis F.

Abstract

A, Predictive models for hospital discharge during the first week in mild patients. B, Predictive models for worsening of clinical status during the first week in patients who were admitted mildly ill. AUC, area under the curve.

Published
2022

30. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

Author

Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Institut d'Investigació Sanitària Pere Virgili, Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugenia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Frederic, Leal, Manuel, Vidal, Francesc, Peraire, Joaquim, Rull, Anna, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Institut d'Investigació Sanitària Pere Virgili, Yeregui, Elena, Masip, Jenifer, Viladés, Consuelo, Domingo, Pere, Pacheco, Yolanda M., Blanco, Julià, Mallolas, Josep, Alba, Verónica, Vargas, Montserrat, García-Pardo, Graciano, Negredo, Eugenia, Olona, Montserrat, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté, Laia, Gómez-Bertomeu, Frederic, Leal, Manuel, Vidal, Francesc, Peraire, Joaquim, and Rull, Anna

Abstract

A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response.

Published
2022

32. Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes

Author

Universitat Rovira i Virgili, Ceperuelo-Mallafre, Victoria; Reverte, Laia; Peraire, Joaquim; Madeira, Ana; Maymo-Masip, Elsa; Lopez-Dupla, Miguel; Gutierrez-Valencia, Alicia; Ruiz-Mateos, Ezequiel; Buzon, Maria Jose; Jorba, Rosa; Vendrell, Joan; Auguet, Teresa; Olona, Montserrat; Vidal, Francesc; Rull, Anna; Fernandez-Veledo, Sonia;COVIDOMICS Study Grp, Universitat Rovira i Virgili, and Ceperuelo-Mallafre, Victoria; Reverte, Laia; Peraire, Joaquim; Madeira, Ana; Maymo-Masip, Elsa; Lopez-Dupla, Miguel; Gutierrez-Valencia, Alicia; Ruiz-Mateos, Ezequiel; Buzon, Maria Jose; Jorba, Rosa; Vendrell, Joan; Auguet, Teresa; Olona, Montserrat; Vidal, Francesc; Rull, Anna; Fernandez-Veledo, Sonia;COVIDOMICS Study Grp

Abstract

BackgroundCoronavirus-19 (COVID-19) disease is driven by an unchecked immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus which alters host mitochondrial-associated mechanisms. Compromised mitochondrial health results in abnormal reprogramming of glucose metabolism, which can disrupt extracellular signalling. We hypothesized that examining mitochondrial energy-related signalling metabolites implicated in host immune response to SARS-CoV-2 infection would provide potential biomarkers for predicting the risk of severe COVID-19 illness. MethodsWe used a semi-targeted serum metabolomics approach in 273 patients with different severity grades of COVID-19 recruited at the acute phase of the infection to determine the relative abundance of tricarboxylic acid (Krebs) cycle-related metabolites with known extracellular signaling properties (pyruvate, lactate, succinate and alpha-ketoglutarate). Abundance levels of energy-related metabolites were evaluated in a validation cohort (n=398) using quantitative fluorimetric assays. ResultsIncreased levels of four energy-related metabolites (pyruvate, lactate, a-ketoglutarate and succinate) were found in critically ill COVID-19 patients using semi-targeted and targeted approaches (p<0.05). The combined strategy proposed herein enabled us to establish that circulating pyruvate levels (p<0.001) together with body mass index (p=0.025), C-reactive protein (p=0.039), D-Dimer (p<0.001) and creatinine (p=0.043) levels, are independent predictors of critical COVID-19. Furthermore, classification and regression tree (CART) analysis provided a cut-off value of pyruvate in serum (24.54 mu M; p<0.001) as an early criterion to accurately classify patients with critical outcomes. ConclusionOur findings support the

Published
2022

33. Lipoprotein Profile in Immunological Non-Responders PLHIV after Antiretroviral Therapy Initiation

Author

Universitat Rovira i Virgili, Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; Veloso, Sergi; Alba, Veronica; Olona, Montserrat; Vidal, Francesc; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Rull, Anna, Universitat Rovira i Virgili, and Masip, Jenifer; Jorba, Rosa; Lopez-Dupla, Miguel; Domingo, Pere; Maria Pacheco, Yolanda; Garcia-Pardo, Graciano; Martinez, Esteban; Vilades, Consuelo; Veloso, Sergi; Alba, Veronica; Olona, Montserrat; Vidal, Francesc; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Rull, Anna

Abstract

Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale (R) tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4(+) T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (p = -0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4(+) T-cell count in PLHIV.

Published
2022

34. Fetuin-A, inter-alpha-trypsin inhibitor, glutamic acid and ChoE (18:0) are key biomarkers in a panel distinguishing mild from critical coronavirus disease 2019 outcomes

Author

Universitat Rovira i Virgili, Reverte, Laia; Yeregui, Elena; Olona, Montserrat; Gutierrez-Valencia, Alicia; Buzon, Maria Jose; Marti, Anna; Gomez-Bertomeu, Frederic; Auguet, Teresa; Lopez-Cortes, Luis F.; Burgos, Joaquin; Benavent-Bofill, Clara; Boque, Carme; Garcia-Pardo, Graciano; Ruiz-Mateos, Ezequiel; Mestre, Maria Teresa; Vidal, Francesc; Vilades, Consuelo; Peraire, Joaquim; Rull, Anna;COVIDOMICS Study Grp, Universitat Rovira i Virgili, and Reverte, Laia; Yeregui, Elena; Olona, Montserrat; Gutierrez-Valencia, Alicia; Buzon, Maria Jose; Marti, Anna; Gomez-Bertomeu, Frederic; Auguet, Teresa; Lopez-Cortes, Luis F.; Burgos, Joaquin; Benavent-Bofill, Clara; Boque, Carme; Garcia-Pardo, Graciano; Ruiz-Mateos, Ezequiel; Mestre, Maria Teresa; Vidal, Francesc; Vilades, Consuelo; Peraire, Joaquim; Rull, Anna;COVIDOMICS Study Grp

Published
2022

35. Elevated α-Ketoglutaric Acid Concentrations and a Lipid-Balanced Signature Are the Key Factors in Long-Term HIV Control

Author

Masip, Jenifer, primary, Rallón, Norma, additional, Yeregui, Elena, additional, Olona, Montserrat, additional, Resino, Salvador, additional, Benito, José M., additional, Viladés, Consuelo, additional, García-Pardo, Graciano, additional, Alcamí, José, additional, Ruiz-Mateos, Ezequiel, additional, Gómez-Bertomeu, Frederic, additional, Vargas, Montserrat, additional, Navarro, Marta, additional, Oteo, José A., additional, Pineda, Juan A., additional, Martí, Anna, additional, Alba, Verónica, additional, Vidal, Francesc, additional, Peraire, Joaquin, additional, and Rull, Anna, additional

Published
2022
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36. Fetuin-A, inter-α-trypsin inhibitor, glutamic acid and ChoE (18:0) are key biomarkers in a panel distinguishing mild from critical coronavirus disease 2019 outcomes

Author

Reverté, Laia, Yeregui, Elena, Olona, Montserrat, Gutiérrez Valencia, Alicia, Buzón, María José, Martí, Anna, Gómez-Bertomeu, Frederic, Auguet, Teresa, López-Cortés, Luis F., Burgos, Joaquín, Benavent-Bofill, Clara, Boqué, Carme, García-Pardo, Graciano, Ruiz-Mateos, Ezequiel, Mestre, María Teresa, Vidal, Francesc, Viladés, Consuelo, Peraire, Joaquim, Rull, Anna, COVIDOMICS Study Group, Generalitat de Catalunya, Instituto de Salud Carlos III, European Commission, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Junta de Andalucía, Consejo Superior de Investigaciones Científicas (España), and Ajuntament de Perafort

Subjects
Medicine (General), R5-920, Treatment Outcome, Alpha-Globulins, Molecular Medicine, Medicine (miscellaneous), COVID-19, Glutamic Acid, Humans, Cholesterol Esters, Severity of Illness Index, Letter to Editor, Biomarkers
Abstract

The mechanistic pathways leading to immune dysregulation and complications driven by uncontrolled severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection remain major challenges.1, 2 Hence, a detailed analysis of the proteome, metabolome and lipidome profile of coronavirus disease 2019 (COVID-19) patients showing different severity grades might shed light on the disease pathophysiology and unveil new predictive biomarkers to promptly ascertain patient's outcomes. Our COVID-19 study cohort included 273 SARS-CoV-2 infected individuals recruited during the first wave (March–April 2020) in three different hospitals and grouped by the disease severity following the medical inclusion criteria3 in mild, severe or critical (Figure 1A), from whom demographic, preexisting clinical conditions and COVID-19 treatments are summarized in Table S1. The greatest significant differences were observed between mild and critically ill patients. These findings indicated that older individuals with comorbidities such as hypertension, obesity, diabetes and cardiovascular disorders, mostly presenting dyspnea (Figure 1B), may be at higher risk of suffering from severe respiratory distress with subsequent oxygen and drug requirements and, eventually, died. Similarly, the serum biochemical composition analysis revealed a well-differentiated blood pattern previously defined for critically ill patients (Figure S1)., This work has been developed in the framework of the COVIDOMICS’ project supported by Direcció General de Recerca i Innovació en Salut (DGRIS), Departament de Salut, Generalitat de Catalunya (PoC-6-17 and PoC1-5). The research has also been funded by the Programa de Suport als Grups de Recerca AGAUR (2017SGR948), the SPANISH AIDS Research Network [RD16/0025/0006, RD16/0025/0007 and RD16/0025/0020]-ISCIII-FEDER (Spain), the Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII [CB21/13/00020], Madrid, Spain and Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades Junta de Andalucía (research Project CV20-85418). Elena Yeregui was supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “FI20/00118″ through the programme “Contratos Predoctorales de Formación en Investigación en Salud”. Laia Revertéwas supported by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CD20/00105″ through the programme “Contratos Sara Borrell”. Francesc Vidal was supported by grants from the Programa de Intensificación de Investigadores (INT20/00031)-ISCIII and by “Premi a la Trajectòria Investigadora dels Hospitals de l’ICS 2018″. Anna Rull was supported by a grant from IISPV through the project “2019/IISPV/05″ (Boosting Young Talent), by GeSIDA through the “III Premio para Jóvenes Investigadores 2019″ and by the Instituto de Salud Carlos III (ISCIII) under grant agreement “CP19/00146″ through the Miguel Servet Program. Maria José Buzón was supported by the Miguel Servet Program (CP17/00179). Ezequiel Ruiz- Mateos was supported by the Spanish Research Council (CSIC). Alicia Gutiérrez-Valencia was supported by the Instituto de Salud Carlos III, cofinanced by the European Development Regional Fund (“A way to achieve Europe”), Subprograma Miguel Servet (grant CP19/00159). This project was also funded by a donation from the city Council of Perafort (to Teresa Auguet).

Published
2022

37. Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

Author

Yeregui, Elena, primary, Masip, Jenifer, additional, Viladés, Consuelo, additional, Domingo, Pere, additional, Pacheco, Yolanda M., additional, Blanco, Julià, additional, Mallolas, Josep, additional, Alba, Verónica, additional, Vargas, Montserrat, additional, García-Pardo, Graciano, additional, Negredo, Eugènia, additional, Olona, Montserrat, additional, Vidal-González, Judit, additional, Peraire, Maria, additional, Martí, Anna, additional, Reverté, Laia, additional, Gómez-Bertomeu, Fréderic, additional, Leal, Manuel, additional, Vidal, Francesc, additional, Peraire, Joaquim, additional, and Rull, Anna, additional

Published
2022
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40. Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers

Author

Malo, Ana-Irene, primary, Peraire, Joaquim, additional, Ruiz-Mateos, Ezequiel, additional, Masip, Jenifer, additional, Amigó, Núria, additional, Alcamí, José, additional, Moreno, Santiago, additional, Girona, Josefa, additional, García-Pardo, Graciano, additional, Reig, Rosaura, additional, Vidal, Francesc, additional, Castro, Antoni, additional, Masana, Lluís, additional, and Rull, Anna, additional

Published
2021
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44. Cardiovascular Disease in Type 1 Diabetes Mellitus : Epidemiology and Management of Cardiovascular Risk

Author

Colom, Cristina, Rull, Anna, Sanchez-Quesada, Jose Luis, Pérez Pérez, Antonio, Colom, Cristina, Rull, Anna, Sanchez-Quesada, Jose Luis, and Pérez Pérez, Antonio

Abstract

Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes mellitus (T1DM) patients, and cardiovascular risk (CVR) remains high even in T1DM patients with good metabolic control. The underlying mechanisms remain poorly understood and known risk factors seem to operate differently in T1DM and type 2 diabetes mellitus (T2DM) patients. However, evidence of cardiovascular risk assessment and management in T1DM patients often is extrapolated from studies on T2DM patients or the general population. In this review, we examine the existing literature about the prevalence of clinical and subclinical CVD, as well as current knowledge about potential risk factors involved in the development and progression of atherosclerosis in T1DM patients. We also discuss current approaches to the stratification and therapeutic management of CVR in T1DM patients. Chronic hyperglycemia plays an important role, but it is likely that other potential factors are involved in increased atherosclerosis and CVD in T1DM patients. Evidence on the estimation of 10-year and lifetime risk of CVD, as well as the efficiency and age at which current cardiovascular medications should be initiated in young T1DM patients, is very limited and clearly insufficient to establish evidence-based therapeutic approaches to CVD management.

Published
2021

45. Evolution of Serum Acute-Phase Glycoproteins Assessed by 1H-NMR in HIV Elite Controllers

Author

Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Malo, Ana-Irene, Peraire, Joaquim, Ruiz-Mateos, Ezequiel, Masip, Jenifer, Amigó, Núria, Alcamí, José, Moreno, Santiago, Girona, Josefa, García-Pardo, Graciano, Reig, Rosauro, Vidal, Francesc, Castro Dorado, Antonio, Masana, Lluis, Rull, Anna, Instituto de Salud Carlos III, European Commission, Agència de Gestió d'Ajuts Universitaris i de Recerca, Red Española de Investigación en SIDA, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), Universidad Rovira i Virgili, Malo, Ana-Irene, Peraire, Joaquim, Ruiz-Mateos, Ezequiel, Masip, Jenifer, Amigó, Núria, Alcamí, José, Moreno, Santiago, Girona, Josefa, García-Pardo, Graciano, Reig, Rosauro, Vidal, Francesc, Castro Dorado, Antonio, Masana, Lluis, and Rull, Anna

Abstract

Elite controllers (ECs) are an exceptional group of people living with HIV (PLWH) who maintain undetectable viral loads (VLs) despite not being on antiretroviral therapy (ART). However, this phenotype is heterogeneous, with some of these subjects losing virological control over time. In this longitudinal retrospective study, serum acute-phase glycoprotein profile assessed by proton nuclear magnetic resonance (1H-NMR) was determined in 11 transient controllers (TCs) who spontaneously lost virological control and 11 persistent controllers (PCs) who persistently maintained virological control over time. Both PCs and TCs showed similar acute-phase glycoprotein profiles, even when TCs lost the virological control (GlycB, p = 0.824 and GlycA, p = 0.710), and the serum acute-phase glycoprotein signature in PCs did not differ from that in HIV-negative subjects (GlycB, p = 0.151 and GlycA, p = 0.243). Differences in serum glycoproteins A and B were significant only in ECs compared to HIV-typical progressors (TPs) with < 100 CD4+ T-cells (p < 0.001). 1H-NMR acute-phase glycoprotein profile does not distinguish TCs form PCs before the loss of viral control. ECs maintain a low-grade inflammatory state compared to TPs. PCs revealed a closer serum signature to HIV-negative subjects, reaffirming this phenotype as a closer model of functional control of HIV.

Published
2021

46. Epigenome-wide association study of COVID-19 severity with respiratory failure

Author

Josep Carreras Leukemia Foundation, Fundació Privada Cellex, Generalitat de Catalunya, Castro de Moura, Manuel, Davalos, Veronica, Planas-Serra, Laura, Álvarez-Errico, Damiana, Arribas, Carles, Ruiz, Montserrat, Aguilera-Albesa, Sergio, Troya, Jesús, Valencia-Ramos, Juan, Vélez-Santamaría, Valentina, Rodríguez-Palmero, Agustí, Villar-García, Judit, Horcajada, Juan Pablo, Albu, Sergiu, Casasnovas, Carlos, Rull, Anna, Reverté, Laia, Dietl, Beatriz, Dalmau, David, Arranz, Maria J., Llucià-Carol, Laia, Planas, Anna M., Pérez-Tur, Jordi, Fernández-Cadenas, Israel, Villares, Paula, Tenorio, Jair, Colobran, Roger, Martin-Nalda, Andrea, Soler-Palacín, Pere, Vidal, Francesc, Pujol, Aurora, Esteller, Manel, Josep Carreras Leukemia Foundation, Fundació Privada Cellex, Generalitat de Catalunya, Castro de Moura, Manuel, Davalos, Veronica, Planas-Serra, Laura, Álvarez-Errico, Damiana, Arribas, Carles, Ruiz, Montserrat, Aguilera-Albesa, Sergio, Troya, Jesús, Valencia-Ramos, Juan, Vélez-Santamaría, Valentina, Rodríguez-Palmero, Agustí, Villar-García, Judit, Horcajada, Juan Pablo, Albu, Sergiu, Casasnovas, Carlos, Rull, Anna, Reverté, Laia, Dietl, Beatriz, Dalmau, David, Arranz, Maria J., Llucià-Carol, Laia, Planas, Anna M., Pérez-Tur, Jordi, Fernández-Cadenas, Israel, Villares, Paula, Tenorio, Jair, Colobran, Roger, Martin-Nalda, Andrea, Soler-Palacín, Pere, Vidal, Francesc, Pujol, Aurora, and Esteller, Manel

Abstract

Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. Methods: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients 61 years of age and without comorbidities, 194 (47.7%) of whom had mild symptomatology that did not involve hospitalization and 213 (52.3%) had a severe clinical course that required respiratory support. The set of cases was divided into discovery (n = 207) and validation (n = 200) cohorts, balanced for age and sex of individuals. We analysed the DNA methylation status of 850,000 CpG sites in these patients. Findings: The DNA methylation status of 44 CpG sites was associated with the clinical severity of COVID-19. Of these loci, 23 (52.3%) were located in 20 annotated coding genes. These genes, such as the inflammasome component Absent in Melanoma 2 (AIM2) and the Major Histocompatibility Complex, class I C (HLA-C) candidates, were mainly involved in the response of interferon to viral infection. We used the EWAS-identified sites to establish a DNA methylation signature (EPICOVID) that is associated with the severity of the disease. Interpretation: We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stratification and management of patients infected with the SARS-CoV-2.

Published
2021

47. Epigenome-wide association study of COVID-19 severity with respiratory failure

Author

Universitat Rovira i Virgili, Castro de Moura, Manuel; Davalos, Veronica; Planas-Serra, Laura; Alvarez-Errico, Damiana; Arribas, Carles; Ruiz, Montserrat; Aguilera-Albesa, Sergio; Troya, Jesus; Valencia-Ramos, Juan; Velez-Santamaria, Valentina; Rodriguez-Palmero, Agusti; Villar-Garcia, Judit; Horcajada, Juan P.; Albu, Sergiu; Casasnovas, Carlos; Rull, Anna; Reverte, Laia; Dietl, Beatriz; Dalmau, David; Arranz, Maria J.; Llucia-Carol, Laia; Planas, Anna M.; Perez-Tur, Jordi; Fernandez-Cadenas, Israel; Villares, Paula; Tenorio, Jair; Colobran, Roger; Martin-Nalda, Andrea; Soler-Palacin, Pere; Vidal, Francesc; Pujol, Aurora; Esteller, Manel, Universitat Rovira i Virgili, and Castro de Moura, Manuel; Davalos, Veronica; Planas-Serra, Laura; Alvarez-Errico, Damiana; Arribas, Carles; Ruiz, Montserrat; Aguilera-Albesa, Sergio; Troya, Jesus; Valencia-Ramos, Juan; Velez-Santamaria, Valentina; Rodriguez-Palmero, Agusti; Villar-Garcia, Judit; Horcajada, Juan P.; Albu, Sergiu; Casasnovas, Carlos; Rull, Anna; Reverte, Laia; Dietl, Beatriz; Dalmau, David; Arranz, Maria J.; Llucia-Carol, Laia; Planas, Anna M.; Perez-Tur, Jordi; Fernandez-Cadenas, Israel; Villares, Paula; Tenorio, Jair; Colobran, Roger; Martin-Nalda, Andrea; Soler-Palacin, Pere; Vidal, Francesc; Pujol, Aurora; Esteller, Manel

Abstract

Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. Methods: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients <= 61 years of age and without comorbidities, 194 (47.7%) of whom had mild symptomatology that did not involve hospitaliza-tion and 213 (52.3%) had a severe clinical course that required respiratory support. The set of cases was divided into discovery (n = 207) and validation (n = 200) cohorts, balanced for age and sex of individuals. We analysed the DNA methylation status of 850,000 CpG sites in these patients. Findings: The DNA methylation status of 44 CpG sites was associated with the clinical severity of COVID-19. Of these loci, 23 (52.3%) were located in 20 annotated coding genes. These genes, such as the inflammasome component Absent in Melanoma 2 (AIM2) and the Major Histocompatibility Complex, class I C (HLA-C) candi-dates, were mainly involved in the response of interferon to viral infection. We used the EWAS-identified sites to establish a DNA methylation signature (EPICOVID) that is associated with the severity of the disease. Interpretation: We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stra

Published
2021

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