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22 results on '"Ruiz-Fernández, Clara"'

3. WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes

Author

Ruiz-Fernández, Clara, González-Rodríguez, María, Abella, Vanessa, Francisco, Vera, Cordero-Barreal, Alfonso, Ait Eldjoudi, Djedjiga, Farrag, Yousof, Pino, Jesús, Conde-Aranda, Javier, González-Gay, Miguel Ángel, Mera, Antonio, Mobasheri, Ali, García-Caballero, Lucía, Gándara-Cortés, Marina, Lago, Francisca, Scotece, Morena, and Gualillo, Oreste

Published
2022
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4. Getting to the Core: Exploring the Embryonic Development from Notochord to Nucleus Pulposus.

Author

Ambrosio, Luca, Schol, Jordy, Ruiz-Fernández, Clara, Tamagawa, Shota, Joyce, Kieran, Nomura, Akira, de Rinaldis, Elisabetta, Sakai, Daisuke, Papalia, Rocco, Vadalà, Gianluca, and Denaro, Vincenzo

Subjects
NUCLEUS pulposus, HUMAN body, LUMBAR pain, TRANSCRIPTION factors, ORGANS (Anatomy), EMBRYOLOGY
Abstract

The intervertebral disc (IVD) is the largest avascular organ of the human body and plays a fundamental role in providing the spine with its unique structural and biomechanical functions. The inner part of the IVD contains the nucleus pulposus (NP), a gel-like tissue characterized by a high content of type II collagen and proteoglycans, which is crucial for the disc's load-bearing and shock-absorbing properties. With aging and IVD degeneration (IDD), the NP gradually loses its physiological characteristics, leading to low back pain and additional sequelae. In contrast to surrounding spinal tissues, the NP presents a distinctive embryonic development since it directly derives from the notochord. This review aims to explore the embryology of the NP, emphasizing the pivotal roles of key transcription factors, which guide the differentiation and maintenance of the NP cellular components from the notochord and surrounding sclerotome. Through an understanding of NP development, we sought to investigate the implications of the critical developmental aspects in IVD-related pathologies, such as IDD and the rare malignant chordomas. Moreover, this review discusses the therapeutic strategies targeting these pathways, including the novel regenerative approaches leveraging insights from NP development and embryology to potentially guide future treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Evaluation of Virola oleifera activity in musculoskeletal pathologies: Inhibition of human multiple myeloma cells proliferation and combination therapy with dexamethasone or bortezomib

Author

Francisco, Vera, Ruiz-Fernández, Clara, González-Rodríguez, María, Cordero-Barreal, Alfonso, Pino, Jesus, Viñuela, Juan E., Lago, Francisca, Conde, Javier, Gómez, Rodolfo, Carvalho, Glaucimeire Rocha, Costa Pereira, Thiago Melo, Campos-Toimil, Manuel, and Gualillo, Oreste

Published
2021
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8. Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage

Author

Farrag, Yousof, primary, Ait Eldjoudi, Djedjiga, additional, Farrag, Mariam, additional, González-Rodríguez, María, additional, Ruiz-Fernández, Clara, additional, Cordero, Alfonso, additional, Varela-García, María, additional, Torrijos Pulpón, Carlos, additional, Bouza, Rebeca, additional, Lago, Francisca, additional, Pino, Jesus, additional, Alvarez-Lorenzo, Carmen, additional, and Gualillo, Oreste, additional

Published
2023
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9. Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer.

Author

González-Rodríguez, María, Ait Edjoudi, Djedjiga, Cordero-Barreal, Alfonso, Farrag, Mariam, Varela-García, María, Torrijos-Pulpón, Carlos, Ruiz-Fernández, Clara, Capuozzo, Maurizio, Ottaiano, Alessandro, Lago, Francisca, Pino, Jesús, Farrag, Yousof, and Gualillo, Oreste

Subjects
OLIVE oil, PHENOLS, MEDITERRANEAN diet, RHEUMATISM, INFLAMMATION
Abstract

Background: The Mediterranean diet is linked to various health benefits, especially the consumption of olive oil as a key component. Multiple studies highlight its advantages, particularly due to its fatty acid composition and additional components like phenolic compounds. A significant antioxidant compound, oleocanthal, known for its antioxidant properties, has gained attention in the pharmaceutical industry for its anti-inflammatory and antiproliferative effects. It shows promise in addressing cardiovascular diseases, metabolic syndrome, and neuroprotection. This systematic review aims to evaluate the existing literature on oleocanthal, examining its role in biological processes and potential impact on conditions like inflammation and cancer. Methods: We performed several searches in PubMed (MEDLINE), Web of Science (WOS), and Cochrane based on the terms "Oleocanthal", "Cancer", and "Inflammation". The inclusion criteria were as follows: studies whose main topics were oleocanthal and cancer or inflammation. On the other hand, the exclusion criteria were studies that were not focused on oleocanthal, reviews, or editorial material. Given that these findings are explanatory rather than derived from clinical trials, we refrained from employing methods to assess potential bias. This systematic review did not receive any external funding. Results: We found 174 records from these searches, where we discarded reviews and editorial material, duplicated articles, and 1 retracted article. Finally, we had 53 reports assessed for eligibility that were included in this review. Discussion: OC exhibits promising therapeutic potential against both inflammation and cancer. We addressed its ability to target inflammatory genes and pathways, offering potential treatments for conditions like rheumatic diseases by regulating pathways such as NF-kB and MAPK. Additionally, OC's anticancer properties, particularly its notable inhibition of c-Met signaling across various cancers, highlight its efficacy, showcasing promise as a potential treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Monomeric CRP regulates inflammatory responses in human intervertebral disc cells

Author

Ruiz-Fernández, Clara, primary, Ait Eldjoudi, Djedjiga, additional, González-Rodríguez, Maria, additional, Cordero Barreal, Alfonso, additional, Farrag, Yousof, additional, García-Caballero, Lucia, additional, Lago, Francisca, additional, Mobasheri, Ali, additional, Sakai, Daisuke, additional, Pino, Jesús, additional, and Gualillo, Oreste, additional

Published
2023
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11. Novel evidence for the role of monomeric C reactive protein and WISP2 in the modulation of catabolic and inflammatory response in cartilage and intervertebral disc

Author

Gualillo, Oreste, Pino Minguez, Jesús, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación Clínica en Medicina, Ruiz Fernández, Clara, Gualillo, Oreste, Pino Minguez, Jesús, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación Clínica en Medicina, and Ruiz Fernández, Clara

Abstract

Low back pain and osteoarthritis (OA) are the two main musculoskeletal diseases cause of disability worldwide, and intervertebral disc degeneration (IVDD) is considered the main cause of low back pain. A sustained inflammatory and catabolic state has been related to the origin and progression of both, OA and IVDD. This research work introduces monomeric C reactive protein (mCRP) pro-inflammatory and catabolic effects in healthy and degenerative human intervertebral disc cells and chondrocytes, suggesting its possible role in the pathophysiology of OA and IVDD. Furthermore, this thesis describes the adipokine WISP2 relevant roles in modulating the turnover of extracellular matrix in cartilage and how its downregulation may detrimentally alter the inflammatory environment in OA joints.

Published
2023

12. Asprosin in health and disease, a new glucose sensor with central and peripheral metabolic effects

Author

Farrag, Mariam, primary, Ait Eldjoudi, Djedjiga, additional, González-Rodríguez, María, additional, Cordero-Barreal, Alfonso, additional, Ruiz-Fernández, Clara, additional, Capuozzo, Maurizio, additional, González-Gay, Miguel Angel, additional, Mera, Antonio, additional, Lago, Francisca, additional, Soffar, Ahmed, additional, Essawy, Amina, additional, Pino, Jesus, additional, Farrag, Yousof, additional, and Gualillo, Oreste, additional

Published
2023
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13. Progranulin in Musculoskeletal Inflammatory and Degenerative Disorders, Focus on Rheumatoid Arthritis, Lupus and Intervertebral Disc Disease: A Systematic Review

Author

González-Rodríguez, María, primary, Ait Edjoudi, Djedjiga, additional, Cordero Barreal, Alfonso, additional, Ruiz-Fernández, Clara, additional, Farrag, Mariam, additional, González-Rodríguez, Beatriz, additional, Lago, Francisca, additional, Capuozzo, Maurizio, additional, Gonzalez-Gay, Miguel Angel, additional, Mera Varela, Antonio, additional, Pino, Jesús, additional, Farrag, Yousof, additional, and Gualillo, Oreste, additional

Published
2022
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15. Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?

Author

Ait Eldjoudi, Djedjiga, primary, Cordero Barreal, Alfonso, additional, Gonzalez-Rodríguez, María, additional, Ruiz-Fernández, Clara, additional, Farrag, Yousof, additional, Farrag, Mariam, additional, Lago, Francisca, additional, Capuozzo, Maurizio, additional, Gonzalez-Gay, Miguel Angel, additional, Mera Varela, Antonio, additional, Pino, Jesús, additional, and Gualillo, Oreste, additional

Published
2022
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16. Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity

Author

Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, González Rodríguez, María, Ruiz Fernández, Clara, Vera, Francisco, Ait Eldjoudi, Djedjiga, Ramadan Farrag Abdel Hafez, Yousof, Cordero Barreal, Alfonso, Pino Mínguez, Jesús, Lago Paz, María Francisca, Campos Toimil, Manuel, Carvalho, Glaucimeire Rocha, Pereira, Thiago Melo Costa, Gualillo, Oreste, Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas, Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, González Rodríguez, María, Ruiz Fernández, Clara, Vera, Francisco, Ait Eldjoudi, Djedjiga, Ramadan Farrag Abdel Hafez, Yousof, Cordero Barreal, Alfonso, Pino Mínguez, Jesús, Lago Paz, María Francisca, Campos Toimil, Manuel, Carvalho, Glaucimeire Rocha, Pereira, Thiago Melo Costa, and Gualillo, Oreste

Abstract

Virola is the largest genus of Myristicaceae in America, comprising about 60 species of medium-sized trees geographically spread from Mexico to southern Brazil. The plant species of this genus have been widely used in folk medicine for the treatment of several ailments, such as rheumatic pain, bronchial asthma, tumors in the joints, intestinal worms, halitosis, ulcers, and multiple infections, due to their pharmacological activity. This review presents an updated and comprehensive summary of Virola species, particularly their ethnomedicinal uses, phytochemistry, and biological activity, to support the safe medicinal use of plant extracts and provide guidance for future research. The Virola spp.’s ethnopharmacology, including in the treatment of stomach pain and gastric ulcers, as well as antimicrobial and tryponosomicidal activities, is attributable to the presence of a myriad of phytoconstituents, such as flavonoids, tannins, phenolic acids, lignans, arylalkanones, and sitosterol. Hence, such species yield potential leads or molecular scaffolds for the development of new pharmaceutical formulations, encouraging the elucidation of not-yet-understood action mechanisms and ascertaining their safety for humans

Published
2021

17. An Update on the Role of Leptin in the Immuno-Metabolism of Cartilage

Author

Cordero-Barreal, Alfonso, primary, González-Rodríguez, María, additional, Ruiz-Fernández, Clara, additional, Eldjoudi, Djedjiga Ait, additional, AbdElHafez, Yousof Ramadan Farrag, additional, Lago, Francisca, additional, Conde, Javier, additional, Gómez, Rodolfo, additional, González-Gay, Miguel Angel, additional, Mobasheri, Ali, additional, Pino, Jesus, additional, and Gualillo, Oreste, additional

Published
2021
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18. Pharmacological Extracts and Molecules from Virola Species: Traditional Uses, Phytochemistry, and Biological Activity

Author

González-Rodríguez, María, primary, Ruiz-Fernández, Clara, additional, Francisco, Vera, additional, Ait Eldjoudi, Djedjiga, additional, Farrag AbdElHafez, Yousof Ramadan, additional, Cordero-Barreal, Alfonso, additional, Pino, Jesus, additional, Lago, Francisca, additional, Campos-Toimil, Manuel, additional, Rocha Carvalho, Glaucimeire, additional, Melo Costa Pereira, Thiago, additional, and Gualillo, Oreste, additional

Published
2021
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22. Obesity, Fat Mass and Immune System: Role for Leptin

Author

Francisco, Vera, primary, Pino, Jesús, additional, Campos-Cabaleiro, Victor, additional, Ruiz-Fernández, Clara, additional, Mera, Antonio, additional, Gonzalez-Gay, Miguel A., additional, Gómez, Rodolfo, additional, and Gualillo, Oreste, additional

Published
2018
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