292 results on '"Ruiz-Contreras, J."'
Search Results
2. PB1037 Bridging for Chronic AVKs Use with Enoxaparin vs Rivaroxaban: A Long-Term, Single-Center, Controller, Prospective Study
- Author
-
Ruiz-Contreras, J., primary, Diaz-Cerda, I., additional, Rubalcava-Lara, L., additional, Alcivar Garcia, M., additional, Garcia Chavez, P., additional, Gutierrez-Gomez, G., additional, and Majluf-Cruz, A., additional
- Published
- 2023
- Full Text
- View/download PDF
3. PB1055 Chronic Anticoagulation in Patients with Liver Failure: A Single-Center Cohort Study
- Author
-
Alcivar GARCIA, M., primary, Gutierrez-Gomez, G., additional, Garcia Chavez, P., additional, Rubalcava-Lara, L., additional, Ruiz-Contreras, J., additional, Diaz-Cerda, I., additional, and Majluf-Cruz, A., additional
- Published
- 2023
- Full Text
- View/download PDF
4. PB0430 Treatment of APS Patients with Rivaroxaban or Apixaban: A Cohort Single-Center Study
- Author
-
Rubalcava-Lara, L., primary, Ruiz-Contreras, J., additional, Diaz-Cerda, I., additional, ALCIVAR Garcia, M., additional, Garcia-Chavez, P., additional, Gutierrez-Gomez, G., additional, and Majluf-Cruz, A., additional
- Published
- 2023
- Full Text
- View/download PDF
5. Respiratory syncytial virus in immunocompromised patients in a paediatric hospital: 5 years’ experience
- Author
-
Domínguez-Pinilla, N., Belda Hofheinz, S., Vivanco Martinez, J.L., Baro-Fernández, M., Ruiz-Contreras, J., and González-Granado, L.I.
- Published
- 2015
- Full Text
- View/download PDF
6. Infección por virus respiratorio sincitial en los pacientes inmunodeprimidos en un hospital pediátrico: experiencia de 5 años
- Author
-
Domínguez-Pinilla, N., Belda Hofheinz, S., Vivanco Martinez, J.L., Baro-Fernández, M., Ruiz-Contreras, J., and González-Granado, L.I.
- Published
- 2015
- Full Text
- View/download PDF
7. Vacunación frente a la gripe estacional en la infancia y la adolescencia. Recomendaciones del Comité Asesor de Vacunas de la Asociación Española de Pediatría para la campaña 2014-2015
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Merino Moína, M., Ruiz-Contreras, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, Á., Hernández-Sampelayo Matos, T., and Ortigosa del Castillo, L.
- Published
- 2014
- Full Text
- View/download PDF
8. Calendario de vacunaciones de la Asociación Española de Pediatría: recomendaciones 2014
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2014
- Full Text
- View/download PDF
9. Vacunación frente a la gripe estacional en la infancia y la adolescencia. Recomendaciones del Comité Asesor de Vacunas de la Asociación Española de Pediatría para la campaña 2013-2014
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Merino Moína, M., Ruiz-Contreras, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., and Ortigosa del Castillo, L.
- Published
- 2013
- Full Text
- View/download PDF
10. Calendario de vacunaciones de la Asociación Española de Pediatría: recomendaciones 2013
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Barrio Corrales, F., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., González-Hachero, J., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2013
- Full Text
- View/download PDF
11. Vacunación contra la gripe estacional en la infancia y la adolescencia. Recomendaciones del Comité Asesor de Vacunas de la Asociación Española de Pediatría para la campaña 2012–2013
- Author
-
Moreno-Pérez, D., Arístegui Fernández, J., Álvarez García, F.J., Merino Moína, M., Ruiz-Contreras, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., Hernández-Sampelayo Matos, T., González-Hachero, J., Barrio Corrales, F., and Ortigosa del Castillo, L.
- Published
- 2012
- Full Text
- View/download PDF
12. Calendario de vacunaciones de la Asociación Española de Pediatría: Recomendaciones 2012
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Barrio Corrales, F., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., González-Hachero, J., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2012
- Full Text
- View/download PDF
13. Immunisation schedule of the Pediatric Spanish Association: 2022 recommendations
- Author
-
Garcia F, Ortega M, Aldean J, Garces-Sanchez M, Llanos E, de Arce A, Melian A, Gomez M, Solas V, Calle I, Ruiz-Contreras J, and Marchuet P
- Abstract
After reviewing the best available scientific information, CAV-AEP publishes their new recommendations to protect pregnant women, children and adolescents living in Spain through vaccination. The same recommendations as the previous year regarding hexavalent vaccines, pneumococcal conjugate vaccine of 13 serotypes, booster with tetanus, diphtheria, pertussis and inactivated poliomyelitis (Tdpa-IPV) at 6 years and with tetanus, diphtheria and pertussis (Tdpa) at 12-14 years and pregnant women from week 27 (from week 20 if there is a high risk of preterm delivery). Also with rotavirus, tetraantigenic meningococcal B (2 + 1), meningococcal quadrivalent (MenACWY), MMR, varicella and human papillomavirus (HPV) vaccines, for both genders. As novelties this year the CAV-AEP recommends:. Influenza vaccination from 6 to 59 months of age whenever feasible and does not harm the vaccination program aimed at people at higher risk. According to official national recommendations, the CAV-AEP recommends the systematic use of COVID mRNA vaccines since 5 years old. (C) 2021 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
- Published
- 2022
14. Clinical Characteristics, Health Care Resource Utilization and Direct Medical Costs of Rotavirus Hospitalizations in Spain (2013-2018)
- Author
-
Arístegui, J., primary, Alfayate-Miguelez, S., additional, Carazo-Gallego, B., additional, Garrote, E., additional, Díaz-Munilla, L., additional, Mendizabal, M., additional, Doménech, E., additional, Ferrer-Lorente, B., additional, Unsaín-Mancisidor, M., additional, Ramos-Amador, J. T., additional, Illán-Ramos, M., additional, Croche-Santander, B., additional, Malfaz, F. Centeno, additional, Rodríguez-Suárez, J., additional, Cotarelo, M., additional, San-Martín, M., additional, Méndez-Hernández, M., additional, and Ruiz-Contreras, J., additional
- Published
- 2021
- Full Text
- View/download PDF
15. Immunisation schedule of the Spanish Association of Paediatrics: 2016 recommendations
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., Merino Moína, M., del Castillo, L. Ortigosa, and Ruiz-Contreras, J.
- Published
- 2016
- Full Text
- View/download PDF
16. Calendario de vacunaciones de la Asociación Española de Pediatría (CAV-AEP): recomendaciones 2016
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2016
- Full Text
- View/download PDF
17. Additional file 1 of Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013���2018
- Author
-
Ruiz-Contreras, J., Alfayate-Miguelez, S., Carazo-Gallego, B., On��s, E., D��az-Munilla, L., Mendizabal, M., M��ndez Hern��ndez, M., Ferrer-Lorente, B., Unsa��n-Mancisidor, M., Ramos-Amador, J. T., Croche-Santander, B., Centeno Malfaz, F., Rodr��guez-Su��rez, J., Cotarelo, M., San-Mart��n, M., and Ar��stegui, J.
- Abstract
Additional file 1: Table S1. List of the study hospitals and VCR of the province.
- Published
- 2021
- Full Text
- View/download PDF
18. Immunisation schedule of the Pediatric Spanish Association: 2021 recommendations
- Author
-
Álvarez García FJ, Cilleruelo Ortega MJ, Álvarez Aldeán J, Garcés-Sánchez M, García Sánchez N, Garrote Llanos E, Hernández Merino Á, Iofrío de Arce A, Montesdeoca Melián A, Navarro Gómez ML, Ruiz-Contreras J, and en representación del Comité Asesor de Vacunas de la Asociación Española de Ped
- Subjects
Vaccines ,Immunisation schedule ,Adolescent ,Vaccine preventable diseases ,Infant ,Child - Abstract
The CAV-AEP annually publishes the immunisation schedule considered optimal for all children and adolescent resident in Spain, taking into account the available evidence. The 2 + 1 schedule is recommended (2, 4, and 11 months) with hexavalent vaccines (DTPa-VPI-Hib-HB) and with 13-valent pneumococcal conjugate.A 6-year booster is recommended, preferably with DTPa (if available), with a dose of polio for those who received 2+ 1 schemes, as welt as vaccination with Tdpa in adolescents and in each pregnancy, preferably between 27 and 32 weeks. Rotavirus vaccine should be systematic for all infants. Meningococcal B vaccine, with a 2 + 1 schedule, should be included in routine calendar. In addition to the inclusion of the conjugated tetravalent meningococcal vaccine (MenACWY) at 12 years of age with catch up to 18 years, inclusive, the CAV recommends this vaccine to be also included at 12 months of age, replacing MenC. Likewise, it is recommended in those over 6 weeks of age with risk factors or who travel to countries with a high incidence of these serogroups. Two-dose schedules for triple viral (12 months and 3-4 years) and varicella (15 months and 3.4 years) will be used. The second dose could be applied as a tetraviral vaccine. Universal systematic vaccination against HPV is recommended, regardless of gender, preferably at 12 years, and greater effort should be made to improve coverage. The 9 genotype extends coverage for both genders. (C) 2020 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
- Published
- 2021
19. Internationally adopted children: What vaccines should they receive?
- Author
-
Cilleruelo, M.J., de Ory, F., Ruiz-Contreras, J., González-González, R., Mellado, M.J., García-Hortelano, M., Villota, J., García-Ascaso, M., Piñeiro, R., Martín-Fontelos, P., and Herruzo, R.
- Published
- 2008
- Full Text
- View/download PDF
20. Neumonía adquirida en la comunidad: tratamiento ambulatorio y prevención
- Author
-
Moreno-Pérez, D., Andrés Martín, A., Tagarro García, A., Escribano Montaner, A., Figuerola Mulet, J., García García, J.J., Moreno-Galdó, A., Rodrigo Gonzalo de Lliria, C., Ruiz Contreras, J., and Saavedra Lozano, J.
- Published
- 2015
- Full Text
- View/download PDF
21. Vaccination against meningococcal B disease. Public statement of the Advisory Committee on Vaccines of the Spanish Association of Paediatrics (CAV-AEP)
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2015
- Full Text
- View/download PDF
22. Vacunación frente al meningococo B. Posicionamiento del Comité Asesor de Vacunas de la Asociación Española de Pediatría
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2015
- Full Text
- View/download PDF
23. Immunisation schedule of the Spanish Association of Paediatrics: 2015 Recommendations
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2015
- Full Text
- View/download PDF
24. Calendario de vacunaciones de la Asociación Española de Pediatría: recomendaciones 2015
- Author
-
Moreno-Pérez, D., Álvarez García, F.J., Arístegui Fernández, J., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., García Sánchez, N., Hernández Merino, A., Hernández-Sampelayo Matos, T., Merino Moína, M., Ortigosa del Castillo, L., and Ruiz-Contreras, J.
- Published
- 2015
- Full Text
- View/download PDF
25. Calendario de vacunaciones de la Asociación Española de Pediatría: recomendaciones 2020
- Author
-
Álvarez García, F.J., Cilleruelo Ortega, M.J., Álvarez Aldeán, J., Garcés-Sánchez, M., García Sánchez, N., Garrote Llanos, E., Hernández Merino, Á., Iofrío de Arce, A., Merino Moína, M., Montesdeoca Melián, A., Navarro Gómez, M.L., Ruiz-Contreras, J., en, representacion, del, Comite, Asesor, de, Vacunas, de, la, Asociacion, Espanola, de, Pediatria, (CAV-AEP), and Composicion, y, filiacion, profesional, de, los, miembros, del, Comite, Asesor, de, Vacunas, de, la, Asociacion, Espanola, de, Pediatria
- Abstract
The CAV-AEP annually publishes the immunisation schedule considered optimal for all children resident in Spain, taking into account the available evidence. The 2 + 1 schedule is recommended (2, 4, and 11 months) with hexavalent vaccines (DTPa-VPI-Hib-HB) and with 13-valent pneumococcal conjugate. A 6-year booster is recommended, preferably with DTPa (if available), with a dose of polio for those who received 2 + 1 schemes, as well as vaccination with Tdpa in adolescents and in each pregnancy, preferably between 27 and 32 weeks. Rotavirus vaccine should be systematic for all infants. Meningococcal B vaccine, with a 2+1 schedule, should be included in routine calendar. In addition to the inclusion of the conjugated tetravalent meningococcal vaccine (MenACWY) at 12 years of age with catch up to 18 years, inclusive, the CAV recommends this vaccine to be also included at 12 months of age, replacing MenC. Likewise, it is recommended in those over 6 weeks of age with risk factors or who travel to countries with a high incidence of these serogroups. Two-dose schedules for MMR (12 months and 3-4 years) and varicella (15 months and 3-4 years) will be used. The second dose could be applied as a tetraviral vaccine. Universal systematic vaccination against HPV is recommended, both for girls and boys, preferably at 12 years, and greater effort should be made to improve coverage. The 9 genotype extends coverage for both genders.
- Published
- 2020
26. Immunisation schedule of the Spanish Association of Paediatrics: 2020 recommendations
- Author
-
Álvarez García FJ, Cilleruelo Ortega MJ, Álvarez Aldeán J, Garcés-Sánchez M, García Sánchez N, Garrote Llanos E, Hernández Merino Á, Iofrío de Arce A, Merino Moína M, Montesdeoca Melián A, Navarro Gómez ML, Ruiz-Contreras J, en representación del Comité Asesor de Vacunas de la Asociación Española de Pedi, and Composición y filiación profesional de los miembros del Comité Asesor de Vacunas
- Subjects
Vaccines ,Immunisation schedule ,Adolescent ,Vaccine preventable diseases ,Infant ,Child - Abstract
The CAV-AEP annually publishes the immunisation schedule considered optimal for all children resident in Spain, taking into account the available evidence. The 2 + 1 schedule is recommended (2, 4, and 11 months) with hexavalent vaccines (DTPa-VPI-Hib-HB) and with 13-valent pneumococcal conjugate. A 6-year booster is recommended, preferably with DTPa (if available), with a dose of polio for those who received 2 + 1 schemes, as well as vaccination with Tdpa in adolescents and in each pregnancy, preferably between 27 and 32 weeks. Rotavirus vaccine should be systematic for all infants. Meningococcal B vaccine, with a 2+1 schedule, should be included in routine calendar. In addition to the inclusion of the conjugated tetravalent meningococcal vaccine (MenACWY) at 12 years of age with catch up to 18 years, inclusive, the CAV recommends this vaccine tobe also included at 12 months of age, replacing MenC. Likewise, it is recommended in those over 6 weeks of age with risk factors or who travel to countries with a high incidence of these serogroups. Two-dose schedules for MMR (12 months and 3-4 years) and varicella (15 months and 3-4years) will be used. The second dose could be applied as a tetraviral vaccine. Universal systematic vaccination against HPV is recommended, both for girls and boys, preferably at 12 years, and greater effort should be made to improve coverage. The 9 genotype extends coverage for both genders. (C) 2019 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
- Published
- 2020
27. Identification of regulatory variants associated with genetic susceptibility to meningococcal disease
- Author
-
Borghini, Lisa, Png, Eileen, Binder, Alexander, Wright, Victoria J, Pinnock, Ellie, de Groot, Ronald, Hazelzet, Jan, Emonts, Marieke, Van der Flier, Michiel, Schlapbach, Luregn J, Anderson, Suzanne, Secka, Fatou, Salas, Antonio, Fink, Colin, Carrol, Enitan D, Pollard, Andrew J, Coin, Lachlan J, Kuijpers, Taco W, Martinon-Torres, Federico, Zenz, Werner, Levin, Michael, Hibberd, Martin L, Davila, Sonia, Gormley, Stuart, Hamilton, Shea, Herberg, Jethro, Hourmat, Bernardo, Hoggart, Clive, Kaforou, Myrsini, Sancho-Shimizu, Vanessa, Abdulla, Amina, Agapow, Paul, Bartlett, Maeve, Bellos, Evangelos, Eleftherohorinou, Hariklia, Galassini, Rachel, Inwald, David, Mashbat, Meg, Menikou, Stefanie, Mustafa, Sobia, Nadel, Simon, Rahman, Rahmeen, Thakker, Clare, Bokhandi, S, Power, Sue, Barham, Heather, Pathan, N, Ridout, Jenna, White, Deborah, Thurston, Sarah, Faust, S, Patel, S, McCorkell, Jenni, Davies, P, Cratev, Lindsey, Navarra, Helen, Carter, Stephanie, Ramaiah, R, Patel, Rekha, Tuffrey, Catherine, Gribbin, Andrew, McCready, Sharon, Peters, Mark, Hardy, Katie, Standing, Fran, O'Neill, Lauren, Abelake, Eugenia, Deep, Akash, Nsirim, Eniola, Willis, Louise, Young, Zoe, Royad, C, White, Sonia, Fortune, PM, Hudnott, Phil, Alvez Gonzalez, Fernando, Barral-Arca, Ruth, Cebey-Lopez, Miriam, Jose Curras-Tuala, Maria, Garcia, Natalia, Garcia Vicente, Luisa, Gomez-Carballa, Alberto, Gomez Rial, Jose, Grela Beiroa, Andrea, Justicia Grande, Antonio, Leborans Iglesias, Pilar, Martinez Santos, Alba Elena, Martinon-Torres, Nazareth, Martinon Sanchez, Jose Maria, Mosquera Perez, Belen, Obando Pacheco, Pablo, Pardo-Seco, Jacobo, Pischedda, Sara, Rivero Calle, Irene, Rodriguez-Tenreiro, Carmen, Redondo-Collazo, Lorenzo, Seren Fernandez, Sonia, Porto Silva, Maria del Sol, Vega, Ana, Beatriz Reyes, Susana, Leon Leon, Maria Cruz, Navarro Mingorance, Alvaro, Gabaldo Barrios, Xavier, Onate Vergara, Eider, Concha Torre, Andres, Vivanco, Ana, Fernandez, Reyes, Gimenez Sanchez, Francisco, Sanchez Forte, Miguel, Rojo, Pablo, Ruiz Contreras, J, Palacios, Alba, Navarro, Marisa, Alvarez Alvarez, Cristina, Jose Lozano, Maria, Carreras, Eduardo, Brio Sanagustin, Sonia, Neth, Olaf, Martinez Padilla, Ma del Carmen, Prieto Tato, Luis Manuel, Guillen, Sara, Fernandez Silveira, Laura, Moreno, David, van Furth, AM Tutu, van der Flier, M, Boeddha, NP, Driessen, GJA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, Philipp, Aebi, Christoph, Berger, Christoph, Giannoni, Eric, Stocker, Martin, Posfay-Barbe, Klara M, Heininger, Ulrich, Bernhard-Stirnemann, Sara, Niederer-Loher, Anita, Kahlert, Christian, Hasters, Paul, Relly, Christa, Baer, Walter, Paulus, Stephane, Frederick, Hannah, Jennings, Rebecca, Johnston, Joanne, Kenwright, Rhian, Agbeko, Rachel, Bojang, Kalifa, Sarr, Isatou, Kebbeh, Ngane, Sey, Gibbi, Saidykhan, Momodou, Cole, Fatoumatta, Thomas, Gilleh, Antonio, Martin, Walcher, Wolfgang, Geishofer, Gotho, Klobassa, Daniela, Martin, Mueller, Pfurtscheller, Klaus, Reiter, Karl, Roedl, Siegfried, Zobel, Gerfried, Zoehrer, Bettina, Toepke, Baerbel, Fucik, Peter, Gabriel, Markwart, Penzien, Johann M, Diab, Gedeon, Miething, Robert, Deeg, KH, Hammer, Jurg, Varnholt, Verena, Schmidt, Andreas, Bindl, Lutz, Sillaber, Ursula, Huemer, Christian, Meier, Primrose, Simic-Schleicher, G, Markart, Markus, Pfau, Eberhard, Broede, Hans, Ausserer, Bernd, Kalhoff, Hermann, Arpe, Volker, Schweitzer-Krantz, Susanne, Kasper, Johannes-Martin, Loranth, Kathrin, Bittrich, Hans J, Simma, Burkhard, Klinge, Jens, Fedlmaier, Michael, Weigand, Nicola, Herting, Egbert, Grube, Regina, Fusch, Christoph, Gruber, Alois, Schimmel, Ulf, Knaufer-Schiefer, Suzanne, Laessig, Wolfgang, Hennenberger, Axel, von der Wense, Axel, Tillmann, Roland, Schwarick, Juergen, Sitzmann, Friedrich C, Streif, Werner, Mueller, Herbert, Kurnik, Peter, Groneck, Peter, Weiss, Ute, Groeblacher-Roth, Helene, Bensch, Juergen, Moser, Reinhard, Schwarz, Rudolf, Lenz, Kurt, Hofmann, Thomas, Goepel, Wolfgang, Schulz, Dietrich, Berger, Thomas, Hauser, Erwin, Foerster, Kai Martin, Peters, Jochen, Nicolai, T Homas, Kumlien, Bjoern, Beckmann, Regina, Seitz, Christiane, Hueseman, D, Schuermann, Roland, Ta, Van Hop, Weikmann, Eckart, Evert, W, Hautz, Juergen, Seidenberg, Juergen, Wocko, Lucia, Luigs, Petra, Reiter, Hans-Ludwig, Quietzach, J, Koenig, Michael, Herrmann, Johanna, Mitter, Horst, Seidler, Ekkehard, Maak, Bernhard, Sperl, Wolfgang, Zwiauer, Karl, Meissl, Manfred, Koch, Reinhard, Cremer, Manfred, Breuer, HA, Goerke, W, Nossal, Robert, Pernice, Walter, Brangenberg, Ralf, Salzer, Hans R, Koch, Hartmut, Schaller, Gerhard, Paky, Franz, Strasser, Friedrich, Eitelberger, Franz, Sontheimer, D, Lischka, Andreas, Kronberger, Martina, Dilch, Alfred, Scheibenpflug, Christian, Bruckner, Robert, Mahler, Klaus, Runge, Klaus, Kunze, Wolfgang, Schermann, Peter, Consortium, EUCLIDS, European Commission, Meningitis Research Foundation, National Institute for Health Research (UK), Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne Hospitals NHS Foundation Trust, Instituto de Salud Carlos III, Xunta de Galicia, Wyeth Farma, Fundación Instituto de Investigación Sanitaria de Santiago de Compostela, Novartis, Swiss National Science Foundation, Swiss Society of Intensive Care Medicine, Gottfried und Julia Bangerter-Rhyner-Stiftung, Vinetum and Borer Foundation, Foundation for the Health of Children and Adolescents, Austrian National Bank, University of Zurich, Borghini, Lisa, Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Png, Eileen [0000-0001-5586-6395], Wright, Victoria J [0000-0001-7826-1516], Schlapbach, Luregn J [0000-0003-2281-2598], Salas, Antonio [0000-0002-2336-702X], Martinon-Torres, Federico [0000-0002-9023-581X], Apollo - University of Cambridge Repository, ARD - Amsterdam Reproduction and Development, AII - Infectious diseases, Paediatric Infectious Diseases / Rheumatology / Immunology, Neurology, ANS - Neuroinfection & -inflammation, Medical Microbiology and Infection Prevention, Pediatrics, Public Health, Posfay Barbe, Klara, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), APH - Aging & Later Life, Amsterdam Reproduction & Development (AR&D), and Pediatric surgery
- Subjects
0301 basic medicine ,Candidate gene ,Hypopharyngeal Neoplasms / microbiology ,Meningococcal Infections / microbiology ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,MathematicsofComputing_GENERAL ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,lcsh:Medicine ,Neisseria meningitidis ,Regulatory Sequences, Nucleic Acid ,Cohort Studies ,0302 clinical medicine ,ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION ,Hypopharyngeal Neoplasms / pathology ,BINDING ,Tumor Cells, Cultured ,lcsh:Science ,Genetics ,Multidisciplinary ,ddc:618 ,Cultured ,TheoryofComputation_GENERAL ,High-Throughput Nucleotide Sequencing ,Genomics ,Phenotype ,3. Good health ,ddc ,Tumor Cells ,Multidisciplinary Sciences ,GENOME ,Science & Technology - Other Topics ,Neisseria meningitidis / isolation & purification ,Single-nucleotide polymorphism ,610 Medicine & health ,KAPPA-B ,Biology ,Hypopharyngeal Neoplasms / genetics ,Polymorphism, Single Nucleotide ,Article ,Meningococcal Infections / epidemiology ,03 medical and health sciences ,SEQUENCE VARIATION ,Genetic predisposition ,Journal Article ,Humans ,Meningitis ,Meningococcal Infections / genetics ,Genetic Predisposition to Disease ,Nucleic Acid ,Polymorphism ,General ,Gene ,Genotyping ,Neisseria meningitidis / genetics ,Genetic Association Studies ,Genetic association ,Genetic association study ,1000 Multidisciplinary ,Science & Technology ,Hypopharyngeal Neoplasms ,genetic variants ,meningococcal disease ,lcsh:R ,Single Nucleotide ,EUCLIDS consortium ,Gene regulation ,Meningococcal Infections ,030104 developmental biology ,10036 Medical Clinic ,Case-Control Studies ,lcsh:Q ,Software_PROGRAMMINGLANGUAGES ,Regulatory Sequences ,030217 neurology & neurosurgery - Abstract
EUCLIDS consortium., Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA – a NF-kB subunit, master regulator of the response to infection – under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes., This work has been partially funded by the European Seventh Framework Programme for Research and Technological Development (FP7) under EUCLIDS Grant Agreement No. 279185. The UK meningococcal cohort was established with support from Meningitis Research Foundation through grants to Imperial College London. The Research from Newcastle partners was supported by the National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals NHS Foundation Trust and Newcastle University. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The ESIGEM Research group activities were supported by grants from Instituto de Salud Carlos III (Proyecto de Investigación en Salud, Acción Estratégica en Salud: proyecto GePEM PI16/01478) (A.S.); Consellería de Sanidade, Xunta de Galicia (RHI07/2-intensificación actividad investigadora, PS09749 and 10PXIB918184PR), Instituto de Salud Carlos III (Intensificación de la actividad investigadora 2007–2016), Convenio de colaboración de investigación (Wyeth España-Fundación IDICHUS 2007–2011), Convenio de colaboración de investigación (Novartis España-Fundación IDICHUS 2010–2011), Fondo de Investigación Sanitaria (FIS; PI070069/PI1000540) del plan nacional de I + D + I and ‘fondos FEDER’ (F.M.T.). The Swiss Pediatric Sepsis study was funded by grants from the Swiss National Science Foundation (342730_153158/1), the Swiss Society of Intensive Care, the Bangerter Foundation, the Vinetum and Borer Foundation, and the Foundation for the Health of Children and Adolescents. The Western Europe Meningococcal Study was supported by grants no 8842, 10112 and 12710 of the Oesterreichische Nationalbank (Austria), grants A3-16.K-8/2008-11 and A3-16.K-8/2006–9 of the Department for Science and Research of the Styrian federal government (Austria) and the non for profit association ‘In Vita’, Graz (Austria).
- Published
- 2019
28. Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
-
Wang, Xinzhu, Nijman, Ruud, Camuzeaux, Stephane, Sands, Caroline, Jackson, Heather, Kaforou, Myrsini, Emonts, Marieke, Herberg, Jethro A, Maconochie, Ian, Carrol, Enitan D, Paulus, Stephane C, Zenz, Werner, Van der Flier, Michiel, de Groot, Ronald, Martinon-Torres, Federico, Schlapbach, Luregn J, Pollard, Andrew J, Fink, Colin, Kuijpers, Taco T, Anderson, Suzanne, Lewis, Matthew R, Levin, Michael, McClure, Myra, Gormley, Stuart, Hamilton, Shea, Hourmat, Bernardo, Hoggart, Clive, Sancho-Shimizu, Vanessa, Wright, Victoria, Abdulla, Amina, Agapow, Paul, Bartlett, Maeve, Bellos, Evangelos, Eleftherohorinou, Hariklia, Galassini, Rachel, Inwald, David, Mashbat, Meg, Menikou, Stefanie, Mustafa, Sobia, Nadel, Simon, Rahman, Rahmeen, Thakker, Clare, Coin, Lachlan MJ, Bokhand, S, Power, Sue, Barham, Heather, Pathan, N, Ridout, Jenna, White, Deborah, Thurston, Sarah, Faust, S, Patel, S, McCorkell, Jenni, Davies, P, Crate, Lindsey, Navarra, Helen, Carter, Stephanie, Ramaiah, R, Patel, Rekha, Tuffrey, Catherine, Gribbin, Andrew, McCready, Sharon, Peters, Mark, Hardy, Katie, Standing, Fran, O'Neill, Lauren, Abelake, Eugenia, Deep, Akash, Nsirim, Eniola, Willis, Louise, Young, Zoe, Royad, C, White, Sonia, Fortune, PM, Hudnott, Phil, Alvez Gonzalez, Fernando, Barral-Arca, Ruth, Cebey-Lopez, Miriam, Jose Curras-Tuala, Maria, Garcia, Natalia, Garcia Vicente, Luisa, Gomez-Carballa, Alberto, Gomez Rial, Jose, Grela Beiroa, Andrea, Justicia Grande, Antonio, Leborans Iglesias, Pilar, Martinez Santos, Alba Elena, MartinonTorres, Nazareth, Martinon Sanchez, Jose Maria, Morillo Gutierrez, Beatriz, Mosquera Perez, Belen, Obando Pacheco, Pablo, Pardo-Seco, Jacobo, Pischedda, Sara, RiveroCalle, Irene, Rodriguez-Tenreiro, Carmen, Redondo-Collazo, Lorenzo, Salas Ellacuriagal, Antonio, Seren Fernandez, Sonia, Porto Silva, Maria del Sol, Vega, Ana, Vilanova Trillo, Lucia, Salas, Antonio, Beatriz Reyes, Susana, Leon Leon, Maria Cruz, Navarro Mingorance, Alvaro, Gabaldo Barrios, Xavier, Onate Vergara, Eider, Concha Torre, Andres, Vivanco, Ana, Fernandez, Reyes, Gimenez Sanchez, Francisco, Sanchez Forte, Miguel, Rojo, Pablo, Ruiz Contreras, J, Palacios, Alba, Epalza Ibarrondo, Cristina, Fernandez Cooke, Elizabeth, Navarro, Marisa, Alvarez Alvarez, Cristina, Jose Lozano, Maria, Carreras, Eduardo, Brio Sanagustin, Sonia, Neth, Olaf, Martinez Padilla, Ma del Carmen, Prieto Tato, Luis Manuel, Guillen, Sara, Fernandez Silveira, Laura, Moreno, David, van Furth, AM Tutu, Boeddha, NP, Driessen, GJA, Emonts, M, Hazelzet, JA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, Philipp, Aebi, Christoph, Berger, Christoph, Giannoni, Eric, Stocker, Martin, Posfay-Barbe, Klara M, Heininger, Ulrich, Bernhard-Stirnemann, Sara, Niederer-Loher, Anita, Kahlert, Christian, Hasters, Paul, Relly, Christa, Baer, Walter, Frederick, Hannah, Jennings, Rebecca, Johnston, Joanne, Kenwright, Rhian, Pinnock, Elli, Agbeko, Rachel, Secka, Fatou, Bojang, Kalifa, Sarr, Isatou, Kebbeh, Ngange, Sey, Gibbi, Momodou, Saidy Khan, Cole, Fatoumata, Thomas, Gilleh, Antonio, Martin, Klobassa, Daniela S, Binder, Alexander, Schweintzger, Nina A, Sagmeister, Manfred, Baumgart, Hinrich, Baumgartner, Markus, Behrends, Uta, Biebl, Ariane, Birnbacher, Robert, Blanke, Jan-Gerd, Boelke, Carsten, Breuling, Kai, Brunner, Juergen, Buller, Maria, Dahlem, Peter, Dietrich, Beate, Eber, Ernst, Elias, Johannes, Emhofer, Josef, Etschmaier, Rosa, Farr, Sebastian, Girtler, Ylenia, Grigorow, Irina, Heimann, Konrad, Ihm, Ulrike, Jaros, Zdenek, Kalhoff, Hermann, Kaulfersch, Wilhelm, Kemen, Christoph, Klocker, Nina, Koester, Bernhard, Kohlmaier, Benno, Komini, Eleni, Kramer, Lydia, Neubert, Antje, Ortner, Daniel, Pescollderungg, Lydia, Pfurtscheller, Klaus, Reiter, Karl, Ristic, Goran, Roedl, Siegfried, Sellner, Andrea, Sonnleitner, Astrid, Sperl, Matthias, Stelzl, Wolfgang, Till, Holger, Trobisch, Andreas, Vierzig, Anne, Vogel, Ulrich, Weingarten, Christina, Welke, Stefanie, Wimmer, Andreas, Wintergerst, Uwe, Wueller, Daniel, Zaunschirm, Andrew, Ziuraite, Ieva, Zukovskaja, Veslava, Consortium, EUCLIDS, Sands, Caroline [0000-0002-3749-7941], Jackson, Heather [0000-0002-1054-9983], Kaforou, Myrsini [0000-0001-9878-4007], Paulus, Stephane C [0000-0002-0703-9114], Martinon-Torres, Federico [0000-0002-9023-581X], Apollo - University of Cambridge Repository, Pediatric surgery, AII - Infectious diseases, Internal medicine, Pathology, Psychiatry, Amsterdam Reproduction & Development (AR&D), Posfay Barbe, Klara, European Commission, National Institute for Health Research (UK), NIHR Biomedical Research Centre (UK), Medical Research Council (UK), Wellcome Trust, Pediatrics, Public Health, Paediatric Infectious Diseases / Rheumatology / Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Neurology, Medical Microbiology and Infection Prevention, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
- Subjects
Male ,0301 basic medicine ,ACCURACY ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,MENINGITIS ,Antibiotics ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,MathematicsofComputing_GENERAL ,lcsh:Medicine ,0601 Biochemistry and Cell Biology ,chemistry.chemical_compound ,0302 clinical medicine ,ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION ,Blood plasma ,030212 general & internal medicine ,Child ,lcsh:Science ,ddc:618 ,Multidisciplinary ,music.instrument ,TheoryofComputation_GENERAL ,Bacterial Infections ,Lipidome ,ddc ,Sphingomyelins ,3. Good health ,Cholesterol ,Virus Diseases ,Child, Preschool ,Female ,Adolescent ,medicine.drug_class ,Bilirubin ,Inositol Phosphates ,0299 Other Physical Sciences ,610 Medicine & health ,DIAGNOSIS ,Fever of Unknown Origin ,Article ,Virus ,Diagnosis, Differential ,03 medical and health sciences ,Lactosylceramide ,Journal Article ,medicine ,Metabolomics ,Humans ,General ,music ,business.industry ,lcsh:R ,Infant ,Lysophosphatidylcholines ,Diagnostic markers ,Omics ,EUCLIDS consortium ,030104 developmental biology ,chemistry ,Immunology ,lcsh:Q ,Software_PROGRAMMINGLANGUAGES ,business ,ddc:600 ,Biomarkers - Abstract
EUCLIDS consortium., Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The ‘omics’ approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics., This work was partially supported by the European Seventh Framework Programme for Research and Technological Development (FP7) under EUCLIDS Grant Agreement no. 279185. ICED: The Research was supported by the National Institute for Health Research Biomedical Research Centre based at Imperial College. This work was further supported by the Medical Research Council and National Institute for Health Research [grant number MC_PC_12025] through funding for the MRC-NIHR National Phenome Centre, infrastructure support was provided by the National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at Imperial NHS Healthcare Trust. MK acknowledges funding from the Wellcome Trust (Sir Henry Wellcome Fellowship grant 206508/Z/17/Z).
- Published
- 2019
29. Síndrome de rubéola congénita en un hospital general tras un brote de rubéola en la Comunidad de Madrid
- Author
-
Arteaga Rodríguez, A., Penín Antón, M., Arrazola Martínez, M.P., Ruiz Contreras, J., and de Juanes Pardo, J.R.
- Published
- 2006
- Full Text
- View/download PDF
30. Impact of antiretroviral protocols on dynamics of AIDS progression markers. (Original Article)
- Author
-
Resino, S., Bellon, J.M., Sanchez-Ramon, S., Gurbindo, D., Ruiz-Contreras, J., Leon, J.A., Ramos, J.T., and Munoz-Fernandez, M.A.
- Subjects
AIDS (Disease) in children -- Development and progression ,HIV infection in children -- Development and progression ,Antiviral agents -- Evaluation ,Family and marriage ,Health ,Evaluation ,Development and progression - Abstract
Aims: To assess the 'real life' effectiveness of different antiretroviral therapies (ART). Methods: A retrospective multicentre observational study in 150 HIV-1 vertically infected children on the progression to AIDS (study [...]
- Published
- 2002
31. Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery
- Author
-
Mancebo, E., Clemente, J., Sanchez, J., Ruiz-Contreras, J., De Pablos, P., Cortezon, S., Romo, E., Paz-Artal, E., and Allende, L. M.
- Published
- 2008
32. Immunisation schedule of the Spanish Association of Paediatrics: 2019 recommendations
- Author
-
Moreno-Pérez D, Álvarez García FJ, Álvarez Aldeán J, Cilleruelo Ortega MJ, Garcés Sánchez M, García Sánchez N, Hernández Merino Á, Méndez Hernández M, Merino Moína M, Montesdeoca Melián A, Ruiz-Contreras J, and en representación del Comité Asesor de Vacunas de la Asociación Española de Pedi
- Subjects
Vaccines ,Immunisation schedule ,Adolescent ,Vaccine preventable diseases ,Infant ,Child - Abstract
The Advisory Committee on Vaccines of the Spanish Association of Paediatrics annually publishes the immunisation schedule considered optimal for children resident in Spain, according to available evidence on current vaccines. As regards funded immunisations, the 2 + 1 strategy (2, 4, 11 months) with hexavalent (DTPa-IPV-Hib-HB) and 13-valent pneumococcal vaccines are recommended. Administration of the 6-year booster dose with DTPa is recommended, with a poliomyelitis dose for children who had received the 2 + 1 scheme, as well as Tdap vaccine for adolescents and pregnant women in every pregnancy between 27 and 32 weeks gestation. The 2-dose scheme should be used for MMR (12 months and 3-4 years) and varicella (15 months and 3-4 years). MMRV vaccine could be applied as the second dose. Vaccination against HPV is recommended in both genders, preferably at 12 years of age. A stronger effort should be made to improve vaccination coverage. The new 9-valent vaccine is now available, expanding the coverage for both genders. Tetravalent meningococcal vaccine (MenACWY) is recommended at 12 months and 12-14 years, with a catch-up up at 19 years of age. It is also recommended in infants older than 6 weeks of age with risk factors, or travellers to countries with high incidence of ACWY meningococcal serogroups. As regards non-funded immunisations, it is recommended meningococcal B vaccination, with a 2 + 1 schedule, and requests that it be included in the National Immunisation Program. Vaccination against rotavirus is recommended in all infants. (C) 2018 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
- Published
- 2019
33. Child hospital admissions associated with influenza virus infection in 6 Spanish cities (2014-2016) Hospitalizaciones infantiles asociadas a infección por virus de la gripe en 6 ciudades de España (2014-2016)
- Author
-
Arístegui Fernández, J., González Pérez-Yarza, E., Mellado Peña, M.J., Rodrigo Gonzalo de Líria, Carlos, Hernández Sampelayo, T., García García, J.J., Ruiz Contreras, J., Moreno Pérez, D., Garrote Llanos, E., Ramos Amador, J.T., Cilla Eguiluz, C.G., Méndez Hernández, M., Aristegui, J., Garrote, E., Larrauri, A., Pérez-Yarza, E.G., Cilla, G., Unsain, M., Contreras, J.R., García-Ochoa, E., Gordillo, J.C., Sampelayo, T.H., Rodríguez, R., González, F., Mellado, M.J., Calvo, C., Méndez, A., Bustamante, J., Salas, D., Lacasta, C., Ramos, J.T., Illán, M., Mendez, M., Barjuan, M., García, J.J., Urraca, S., Caballero, M., Launes, C., Fábregas Martori, Ana, Esmel Vilomara, Roger, Antón, Andrés, Moreno, D., Valdivielso, A.I., Piñero, P., and Carazo, B.
- Subjects
Virus de la gripe ,Hospitalizaciones ,Influenza virus ,Children ,Niños ,Hospital admissions - Abstract
Introduction: There are only a limited number of studies on the impact of influenza in the Spanish child population. The present work intends to increase this knowledge by studying some key aspects, such as the incidence of hospital admissions, clinic variables, comorbidities, and the vaccination status in the hospitalised children. Methods: A retrospective, observational study was conducted by reviewing the medical records of children under 15 years and hospitalised due to community acquired influenza confirmed microbiologically, during 2 ́flu seasons (2014-2015 and 2015-2016). The study was carried out in 10 hospitals of 6 cities, which represent approximately 12% of the Spanish child population. Results: A total of 907 children were admitted to hospital with main diagnosis of influenza infection (447 < 2 years), estimating an average annual rate of hospitalisation incidence of 0.51 cases / 1,000 children (95% CI; 0.48-0.55). Just under half (45%) of the cases had an underlying disease considered a risk factor for severe influenza, and most (74%) had not been vaccinated. The percentage of children with underlying diseases increased with age, from 26% in children < 6 months to 74% in children >10 years. Admission to the PICU was required in 10% (92) of the cases, mainly due to acute respiratory failure. Conclusion: Influenza continues to be an important cause of hospitalisation in the Spanish child population. Children < 6 months of age and children with underlying diseases make up the majority (> 50%) of the cases. Many of the severe forms of childhood influenza that occur today could be avoided if current vaccination guidelines were met.
- Published
- 2019
34. Hospitalizaciones infantiles asociadas a infección por virus de la gripe en 6 ciudades de España (2014-2016)
- Author
-
Arístegui Fernández J, González Pérez-Yarza E, Mellado Peña MJ, Rodrigo Gonzalo de Liria C, Hernández Sampelayo T, García-García JJ, Ruiz Contreras J, Moreno Pérez D, Garrote Llanos E, Ramos Amador JT, Cilla Eguiluz CG, and Méndez Hernández M
- Subjects
Children, Hospital admissions, Hospitalizaciones, Influenza virus, Niños, Virus de la gripe - Abstract
There are only a limited number of studies on the impact of influenza in the Spanish child population. The present work intends to increase this knowledge by studying some key aspects, such as the incidence of hospital admissions, clinic variables, comorbidities, and the vaccination status in the hospitalised children.
- Published
- 2019
35. Detection of vertical transmission of human immunodeficiency virus type 1 by a commercial polymerase chain reaction assay
- Author
-
Bermúdez, P., Moreno, P., Delgado, R., Ramos, J. T., Ruiz-Contreras, J., and Noriega, A. R.
- Published
- 1996
- Full Text
- View/download PDF
36. Identification of regulatory variants associated with genetic susceptibility to meningococcal disease
- Author
-
Borghini, L, Png, E, Binder, A, Wright, VJ, Pinnock, E, de Groot, R, Hazelzet, J, Emonts, M, Van der Flier, M, Schlapbach, LJ, Anderson, S, Secka, F, Salas, A, Fink, C, Carrol, ED, Pollard, AJ, Coin, LJ, Kuijpers, TW, Martinon-Torres, F, Zenz, W, Levin, M, Hibberd, ML, Davila, S, Gormley, S, Hamilton, S, Herberg, J, Hourmat, B, Hoggart, C, Kaforou, M, Sancho-Shimizu, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Bokhandi, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Cratev, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Alvez Gonzalez, F, Barral-Arca, R, Cebey-Lopez, M, Jose Curras-Tuala, M, Garcia, N, Garcia Vicente, L, Gomez-Carballa, A, Gomez Rial, J, Grela Beiroa, A, Justicia Grande, A, Leborans Iglesias, P, Martinez Santos, AE, Martinon-Torres, N, Martinon Sanchez, JM, Mosquera Perez, B, Obando Pacheco, P, Pardo-Seco, J, Pischedda, S, Rivero Calle, I, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Seren Fernandez, S, Porto Silva, MDS, Vega, A, Beatriz Reyes, S, Leon Leon, MC, Navarro Mingorance, A, Gabaldo Barrios, X, Onate Vergara, E, Concha Torre, A, Vivanco, A, Fernandez, R, Gimenez Sanchez, F, Sanchez Forte, M, Rojo, P, Ruiz Contreras, J, Palacios, A, Navarro, M, Alvarez Alvarez, C, Jose Lozano, M, Carreras, E, Brio Sanagustin, S, Neth, O, Martinez Padilla, MDC, Prieto Tato, LM, Guillen, S, Fernandez Silveira, L, Moreno, D, van Furth, AMT, van der Flier, M, Boeddha, NP, Driessen, GJA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Berger, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Paulus, S, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Agbeko, R, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Saidykhan, M, Cole, F, Thomas, G, Antonio, M, Walcher, W, Geishofer, G, Klobassa, D, Martin, M, Pfurtscheller, K, Reiter, K, Roedl, S, Zobel, G, Zoehrer, B, Toepke, B, Fucik, P, Gabriel, M, Penzien, JM, Diab, G, Miething, R, Deeg, KH, Hammer, J, Varnholt, V, Schmidt, A, Bindl, L, Sillaber, U, Huemer, C, Meier, P, Simic-Schleicher, G, Markart, M, Pfau, E, Broede, H, Ausserer, B, Kalhoff, H, Arpe, V, Schweitzer-Krantz, S, Kasper, J-M, Loranth, K, Bittrich, HJ, Simma, B, Klinge, J, Fedlmaier, M, Weigand, N, Herting, E, Grube, R, Fusch, C, Gruber, A, Schimmel, U, Knaufer-Schiefer, S, Laessig, W, Hennenberger, A, von der Wense, A, Tillmann, R, Schwarick, J, Sitzmann, FC, Streif, W, Mueller, H, Kurnik, P, Groneck, P, Weiss, U, Groeblacher-Roth, H, Bensch, J, Moser, R, Schwarz, R, Lenz, K, Hofmann, T, Goepel, W, Schulz, D, Berger, T, Hauser, E, Foerster, KM, Peters, J, Nicolai, TH, Kumlien, B, Beckmann, R, Seitz, C, Hueseman, D, Schuermann, R, Ta, VH, Weikmann, E, Evert, W, Hautz, J, Seidenberg, J, Wocko, L, Luigs, P, Reiter, H-L, Quietzach, J, Koenig, M, Herrmann, J, Mitter, H, Seidler, E, Maak, B, Sperl, W, Zwiauer, K, Meissl, M, Koch, R, Cremer, M, Breuer, HA, Goerke, W, Nossal, R, Pernice, W, Brangenberg, R, Salzer, HR, Koch, H, Schaller, G, Paky, F, Strasser, F, Eitelberger, F, Sontheimer, D, Lischka, A, Kronberger, M, Dilch, A, Scheibenpflug, C, Bruckner, R, Mahler, K, Runge, K, Kunze, W, Schermann, P, Borghini, L, Png, E, Binder, A, Wright, VJ, Pinnock, E, de Groot, R, Hazelzet, J, Emonts, M, Van der Flier, M, Schlapbach, LJ, Anderson, S, Secka, F, Salas, A, Fink, C, Carrol, ED, Pollard, AJ, Coin, LJ, Kuijpers, TW, Martinon-Torres, F, Zenz, W, Levin, M, Hibberd, ML, Davila, S, Gormley, S, Hamilton, S, Herberg, J, Hourmat, B, Hoggart, C, Kaforou, M, Sancho-Shimizu, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Bokhandi, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Cratev, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Alvez Gonzalez, F, Barral-Arca, R, Cebey-Lopez, M, Jose Curras-Tuala, M, Garcia, N, Garcia Vicente, L, Gomez-Carballa, A, Gomez Rial, J, Grela Beiroa, A, Justicia Grande, A, Leborans Iglesias, P, Martinez Santos, AE, Martinon-Torres, N, Martinon Sanchez, JM, Mosquera Perez, B, Obando Pacheco, P, Pardo-Seco, J, Pischedda, S, Rivero Calle, I, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Seren Fernandez, S, Porto Silva, MDS, Vega, A, Beatriz Reyes, S, Leon Leon, MC, Navarro Mingorance, A, Gabaldo Barrios, X, Onate Vergara, E, Concha Torre, A, Vivanco, A, Fernandez, R, Gimenez Sanchez, F, Sanchez Forte, M, Rojo, P, Ruiz Contreras, J, Palacios, A, Navarro, M, Alvarez Alvarez, C, Jose Lozano, M, Carreras, E, Brio Sanagustin, S, Neth, O, Martinez Padilla, MDC, Prieto Tato, LM, Guillen, S, Fernandez Silveira, L, Moreno, D, van Furth, AMT, van der Flier, M, Boeddha, NP, Driessen, GJA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Berger, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Paulus, S, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Agbeko, R, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Saidykhan, M, Cole, F, Thomas, G, Antonio, M, Walcher, W, Geishofer, G, Klobassa, D, Martin, M, Pfurtscheller, K, Reiter, K, Roedl, S, Zobel, G, Zoehrer, B, Toepke, B, Fucik, P, Gabriel, M, Penzien, JM, Diab, G, Miething, R, Deeg, KH, Hammer, J, Varnholt, V, Schmidt, A, Bindl, L, Sillaber, U, Huemer, C, Meier, P, Simic-Schleicher, G, Markart, M, Pfau, E, Broede, H, Ausserer, B, Kalhoff, H, Arpe, V, Schweitzer-Krantz, S, Kasper, J-M, Loranth, K, Bittrich, HJ, Simma, B, Klinge, J, Fedlmaier, M, Weigand, N, Herting, E, Grube, R, Fusch, C, Gruber, A, Schimmel, U, Knaufer-Schiefer, S, Laessig, W, Hennenberger, A, von der Wense, A, Tillmann, R, Schwarick, J, Sitzmann, FC, Streif, W, Mueller, H, Kurnik, P, Groneck, P, Weiss, U, Groeblacher-Roth, H, Bensch, J, Moser, R, Schwarz, R, Lenz, K, Hofmann, T, Goepel, W, Schulz, D, Berger, T, Hauser, E, Foerster, KM, Peters, J, Nicolai, TH, Kumlien, B, Beckmann, R, Seitz, C, Hueseman, D, Schuermann, R, Ta, VH, Weikmann, E, Evert, W, Hautz, J, Seidenberg, J, Wocko, L, Luigs, P, Reiter, H-L, Quietzach, J, Koenig, M, Herrmann, J, Mitter, H, Seidler, E, Maak, B, Sperl, W, Zwiauer, K, Meissl, M, Koch, R, Cremer, M, Breuer, HA, Goerke, W, Nossal, R, Pernice, W, Brangenberg, R, Salzer, HR, Koch, H, Schaller, G, Paky, F, Strasser, F, Eitelberger, F, Sontheimer, D, Lischka, A, Kronberger, M, Dilch, A, Scheibenpflug, C, Bruckner, R, Mahler, K, Runge, K, Kunze, W, and Schermann, P
- Abstract
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes.
- Published
- 2019
37. Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
-
Wang, X, Nijman, R, Camuzeaux, S, Sands, C, Jackson, H, Kaforou, M, Emonts, M, Herberg, JA, Maconochie, I, Carrol, ED, Paulus, SC, Zenz, W, Van der Flier, M, de Groot, R, Martinon-Torres, F, Schlapbach, LJ, Pollard, AJ, Fink, C, Kuijpers, TT, Anderson, S, Lewis, MR, Levin, M, McClure, M, Gormley, S, Hamilton, S, Hourmat, B, Hoggart, C, Sancho-Shimizu, V, Wright, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Coin, LMJ, Bokhand, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Crate, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Alvez Gonzalez, F, Barral-Arca, R, Cebey-Lopez, M, Jose Curras-Tuala, M, Garcia, N, Garcia Vicente, L, Gomez-Carballa, A, Gomez Rial, J, Grela Beiroa, A, Justicia Grande, A, Leborans Iglesias, P, Martinez Santos, AE, MartinonTorres, N, Martinon Sanchez, JM, Morillo Gutierrez, B, Mosquera Perez, B, Obando Pacheco, P, Pardo-Seco, J, Pischedda, S, RiveroCalle, I, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Salas Ellacuriagal, A, Seren Fernandez, S, Porto Silva, MDS, Vega, A, Vilanova Trillo, L, Salas, A, Beatriz Reyes, S, Leon Leon, MC, Navarro Mingorance, A, Gabaldo Barrios, X, Onate Vergara, E, Concha Torre, A, Vivanco, A, Fernandez, R, Gimenez Sanchez, F, Sanchez Forte, M, Rojo, P, Ruiz Contreras, J, Palacios, A, Epalza Ibarrondo, C, Fernandez Cooke, E, Navarro, M, Alvarez Alvarez, C, Jose Lozano, M, Carreras, E, Brio Sanagustin, S, Neth, O, Martinez Padilla, MDC, Prieto Tato, LM, Guillen, S, Fernandez Silveira, L, Moreno, D, van Furth, AMT, Boeddha, NP, Driessen, GJA, Hazelzet, JA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Berger, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Pinnock, E, Agbeko, R, Secka, F, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Momodou, SK, Cole, F, Thomas, G, Antonio, M, Klobassa, DS, Binder, A, Schweintzger, NA, Sagmeister, M, Baumgart, H, Baumgartner, M, Behrends, U, Biebl, A, Birnbacher, R, Blanke, J-G, Boelke, C, Breuling, K, Brunner, J, Buller, M, Dahlem, P, Dietrich, B, Eber, E, Elias, J, Emhofer, J, Etschmaier, R, Farr, S, Girtler, Y, Grigorow, I, Heimann, K, Ihm, U, Jaros, Z, Kalhoff, H, Kaulfersch, W, Kemen, C, Klocker, N, Koester, B, Kohlmaier, B, Komini, E, Kramer, L, Neubert, A, Ortner, D, Pescollderungg, L, Pfurtscheller, K, Reiter, K, Ristic, G, Roedl, S, Sellner, A, Sonnleitner, A, Sperl, M, Stelzl, W, Till, H, Trobisch, A, Vierzig, A, Vogel, U, Weingarten, C, Welke, S, Wimmer, A, Wintergerst, U, Wueller, D, Zaunschirm, A, Ziuraite, I, Zukovskaja, V, Wang, X, Nijman, R, Camuzeaux, S, Sands, C, Jackson, H, Kaforou, M, Emonts, M, Herberg, JA, Maconochie, I, Carrol, ED, Paulus, SC, Zenz, W, Van der Flier, M, de Groot, R, Martinon-Torres, F, Schlapbach, LJ, Pollard, AJ, Fink, C, Kuijpers, TT, Anderson, S, Lewis, MR, Levin, M, McClure, M, Gormley, S, Hamilton, S, Hourmat, B, Hoggart, C, Sancho-Shimizu, V, Wright, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Coin, LMJ, Bokhand, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Crate, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Alvez Gonzalez, F, Barral-Arca, R, Cebey-Lopez, M, Jose Curras-Tuala, M, Garcia, N, Garcia Vicente, L, Gomez-Carballa, A, Gomez Rial, J, Grela Beiroa, A, Justicia Grande, A, Leborans Iglesias, P, Martinez Santos, AE, MartinonTorres, N, Martinon Sanchez, JM, Morillo Gutierrez, B, Mosquera Perez, B, Obando Pacheco, P, Pardo-Seco, J, Pischedda, S, RiveroCalle, I, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Salas Ellacuriagal, A, Seren Fernandez, S, Porto Silva, MDS, Vega, A, Vilanova Trillo, L, Salas, A, Beatriz Reyes, S, Leon Leon, MC, Navarro Mingorance, A, Gabaldo Barrios, X, Onate Vergara, E, Concha Torre, A, Vivanco, A, Fernandez, R, Gimenez Sanchez, F, Sanchez Forte, M, Rojo, P, Ruiz Contreras, J, Palacios, A, Epalza Ibarrondo, C, Fernandez Cooke, E, Navarro, M, Alvarez Alvarez, C, Jose Lozano, M, Carreras, E, Brio Sanagustin, S, Neth, O, Martinez Padilla, MDC, Prieto Tato, LM, Guillen, S, Fernandez Silveira, L, Moreno, D, van Furth, AMT, Boeddha, NP, Driessen, GJA, Hazelzet, JA, Pajkrt, D, Sanders, EAM, van de Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Berger, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Pinnock, E, Agbeko, R, Secka, F, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Momodou, SK, Cole, F, Thomas, G, Antonio, M, Klobassa, DS, Binder, A, Schweintzger, NA, Sagmeister, M, Baumgart, H, Baumgartner, M, Behrends, U, Biebl, A, Birnbacher, R, Blanke, J-G, Boelke, C, Breuling, K, Brunner, J, Buller, M, Dahlem, P, Dietrich, B, Eber, E, Elias, J, Emhofer, J, Etschmaier, R, Farr, S, Girtler, Y, Grigorow, I, Heimann, K, Ihm, U, Jaros, Z, Kalhoff, H, Kaulfersch, W, Kemen, C, Klocker, N, Koester, B, Kohlmaier, B, Komini, E, Kramer, L, Neubert, A, Ortner, D, Pescollderungg, L, Pfurtscheller, K, Reiter, K, Ristic, G, Roedl, S, Sellner, A, Sonnleitner, A, Sperl, M, Stelzl, W, Till, H, Trobisch, A, Vierzig, A, Vogel, U, Weingarten, C, Welke, S, Wimmer, A, Wintergerst, U, Wueller, D, Zaunschirm, A, Ziuraite, I, and Zukovskaja, V
- Abstract
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics.
- Published
- 2019
38. Partial immune reconstitution after bone marrow transplantation in a boy with recombination activating gene 1 defect
- Author
-
Muñoz-Robles, J, Del Rey, M J, Ruiz-Contreras, J, Clemente, J, Ramos, J T, Paz-Artal, E, and Allende, L M
- Published
- 2004
39. Epidemiology and economic impact of varicella in immunocompetent children in Spain.: A nation-wide study
- Author
-
Dı́ez-Domingo, J., Aristegui, J., Calbo, F., Gonzalez-Hachero, J., Moraga, F., Peña Guitian, J., Ruiz Contreras, J., and Torrellas, A.
- Published
- 2003
- Full Text
- View/download PDF
40. Calendario vacunal de la Asociación Española de Pediatría (AEP) 2001–2002
- Author
-
de Arístegui Fernández, J., Ruiz Contreras, J., Corretger Rauet, J.M., García Martín, F., Hernández Sampelayo, T., Moraga Llop, F., Rodrigo Gonzalo de Liria, C., Calbo Torrecillas, F., Fontán Casariego, G., and Muñiz Saitua, J.
- Published
- 2001
- Full Text
- View/download PDF
41. Calendario vacunal de la Asociación Española de Pediatría
- Author
-
Arístegui Fernández, J., Ruiz Contreras, J., Corretger Rauet, J.M., García Martín, F., Hernández Sampelayo, T., Moraga Llop, F., Rodrigo Gonzalo de Liria, C., Calbo Torrecillas, F., Fontán Casariego, G., and Muñiz Saitua, J.
- Published
- 2000
- Full Text
- View/download PDF
42. Vacunación frente a la gripe estacional en la infancia y la adolescencia. Recomendaciones del Comité Asesor de Vacunas de la Asociación Española de Pediatría (CAV-AEP) para la campaña antigripal 2016-2017
- Author
-
Moreno Pérez, D., García Sánchez, N., Arístegui Fernández, J., Ruiz Contreras, J., Álvarez García, F.J., Hernández Merino, Á., Merino Moína, M., Cilleruelo Ortega, M.J., Corretger Rauet, J.M., Hernández-Sampelayo Matos, T., Ortigosa, Del Castillo, and Comité Asesor De Vacunas De La Asociación Española, De Pediatr
- Abstract
The Advisory Committee on Immunization of the Spanish Association of Paediatrics issues its recommendations about vaccination against influenza virus in children and adolescents every year before the onset of the flu season. Influenza vaccination is particularly beneficial when aimed at individuals, both children and adults, who are included in the population groups considered at risk. However, for various reasons, many children and adolescents with underlying conditions and their contacts are still not given this vaccination annually. There is a need for a greater involvement of health professionals, health authorities and all social agents to inform the population, especially to the parents of children and adolescents in those risk groups, on the recommendations for seasonal influenza vaccination. In this document, current recommendations for influenza vaccination for the 2016-2017 season are presented, and reasons and limitations are explained. The recommendation for influenza vaccination is emphasized for health professionals.
- Published
- 2016
43. Vacunación frente a la gripe estacional en la infancia y la adolescencia. Recomendaciones del Comité Asesor de Vacunas de la Asociación Española de Pediatría (CAV-AEP) para la campaña antigripal 2016-2017
- Author
-
Moreno Pérez,D, García Sánchez,N, Arístegui Fernández,J, Ruiz Contreras,J, Álvarez García,FJ, Hernández Merino,A, Merino Moína,M, Cilleruelo Ortega,MJ, Corretger Rauet,JM, Hernández-Sampelayo Matos,T, and Ortigosa del Castillo,L
- Subjects
Vacunas ,Inmunizaciones ,Gripe ,Enfermedades crónicas ,Adolescentes ,Niños - Abstract
Resumen: El Comité Asesor de Vacunas de la Asociación Española de Pediatría (CAV-AEP) emite todos los años sus recomendaciones sobre la vacunación frente a este virus en la infancia y la adolescencia. La vacunación de la gripe es una actuación especialmente beneficiosa cuando va dirigida a personas -niños y adultos- que se incluyen en los grupos de población considerados de riesgo. Sin embargo, muchos niños y adolescentes pertenecientes a estos grupos de riesgo, y sus convivientes, continúan sin recibir, por distintas razones, dicha vacunación anual. Asimismo, se insiste en la recomendación de la vacunación de los profesionales sanitarios. En el presente documento se presentan las recomendaciones para la vacunación antigripal en la temporada 2016-2017, y se explican los fundamentos y limitaciones de las mismas. Es necesaria una mayor implicación de los profesionales, las autoridades sanitarias y todos los agentes sociales para transmitir cada año a la población, y de forma especial a los padres de niños y adolescentes pertenecientes a los grupos de riesgo, las recomendaciones de vacunación frente a la gripe estacional.
- Published
- 2016
44. Idiopathic CD4+ T lymphocytopenia disclosed after the diagnosis of visceral leishmaniasis
- Author
-
Lopez-Medrano, F., Aguado, J.M., Ruiz-Contreras, J., Alvarez, N., Delgado, J.M., San Juan, R., and Lizasoain, M.
- Subjects
Lymphocytopenia -- Diagnosis ,Lymphocytopenia -- Development and progression ,Kala-azar -- Diagnosis ,Health ,Health care industry - Published
- 2007
45. Conocimientos sobre ética asistencial de los residentes de Pediatría
- Author
-
Moreno Villares, J.M., primary and Ruiz Contreras, J., additional
- Published
- 2015
- Full Text
- View/download PDF
46. Calendario de vacunaciones de la Asociación Española de Pediatría: recomendaciones 2014
- Author
-
Moreno Pérez, D., primary, Álvarez García, F. J., additional, Arístegui Fernández, J. de, additional, Cilleruelo Ortega, M. J., additional, Corretger Rauet, J. M., additional, García Sánchez, N., additional, Hernández Merino, A., additional, Hernández-Sampelayo Matos, T., additional, Merino Moína, M., additional, Ortigosa del Castillo, L., additional, and Ruiz-Contreras, J., additional
- Published
- 2014
- Full Text
- View/download PDF
47. Calendario de vacunaciones de la Asociación Española de Pediatría: recomendaciones 2014
- Author
-
Moreno-Pérez, D., primary, Álvarez García, F.J., additional, Arístegui Fernández, J., additional, Cilleruelo Ortega, M.J., additional, Corretger Rauet, J.M., additional, García Sánchez, N., additional, Hernández Merino, A., additional, Hernández-Sampelayo Matos, T., additional, Merino Moína, M., additional, Ortigosa del Castillo, L., additional, and Ruiz-Contreras, J., additional
- Published
- 2014
- Full Text
- View/download PDF
48. Inter-laboratory comparison of HCV-RNA assay results: Implications for multi-centre research
- Author
-
Pembrey, L. Newell, M.-L. Tovo, P.-A. Van Drimmelen, H. Quinti, I. Furlini, G. Galli, S. Meliconi, M.G. Burns, S. Hallam, N. Sönnerborg, A. Cilia, G. Serrano, E. Laccetti, P. Portella, G. Polywka, S. Icardi, G. Bruzzone, B. Balbo, L. Alfarano, A. Amoroso, A. Asensi-Botet, F. Bona, G. Boucher, C. Buffolano, W. Butler, K. Cabero Roura, L. Bertran Sanges, J.M. Cigna, P. Ciria, L.M. Servera Ginard, C. Coll, O. Fortuny, C. Corrias, A. Ledda, R. Floris, S. De Maria, A. Echeverria, J. Cilla, G. Fabris, C. Feiterna Sperling, C. Grosch-Wörner, I. Fischler, B. Bohlin, A.-B. Fjaerli, H.A. Hannam, S. Mieli-Vergani, G. Hatzakis, A. Lanari, M. Papa, I. Venturi, V. Leon Leal, J.A. Lyall, H. Maccabruni, A. Pacati, I. Arlandi, L. Marcellini, M. Martin Fontelos, P. Mazza, A. Mok, J.Y.Q. Mûr, A. Viñolas, M. Palomba, E. Riva, C. Scolfaro, C. Paternoster, D.M. Grella, P. Casadei, A.M. Rojahn, A. Rosso, R. Bassetti, D. Ruiz Contreras, J. Manzanares, A. Ruiz Extremera, A. Souayah, H. Levy, J. Tudor-Williams, G. Vegnente, A. Wejstal, R. Norkrans, G. Zanetti, A. Tanzi, E. Zuccotti, G.V. Zuin, G. Saccani, B. Vigano, A.
- Abstract
To investigate whether it is appropriate to assume comparability of hepatitis virus C (HCV)-RNA results across laboratories in multi-centre studies, nine laboratories of the European Paediatric HCV Network participated in an international proficiency study of HCV-RNA assays. A panel of 12 samples of different dilutions and genotypes was sent to each laboratory and tested with qualitative and/or quantitative HCV-RNA assays according to local procedures. Commercial assays were used in seven laboratories and in-house assays in two. All six laboratories in which a commercial qualitative assay was used were proficient, as were four of six runs (in five laboratories) in which a commercial quantitative assay was used. The proficiency of the laboratories where in-house assays were used could not be assessed according to the VQC definition because of differences in the methods used. Overall, there were several false-negative results, but only one false-positive result with a quantitative assay and none with a qualitative assay. The false-negative results may have implications for the diagnosis of infection, and highlight the need for an antibody test to be performed at 18 months to confirm the absence of infection. The results of qualitative assays were generally consistent across laboratories but it was difficult to evaluate and compare the results of quantitative assays. Multivariate analysis of data collected in multi-centre studies should therefore allow for centre and/or assay used. © 2003 Wiley-Liss, Inc.
- Published
- 2003
49. Tuberculous paradoxical reaction with bone involvement
- Author
-
Blazquez, D., primary, Ainsa-Laguna, D., additional, and Ruiz-Contreras, J., additional
- Published
- 2013
- Full Text
- View/download PDF
50. Eosinofilia masiva en paciente oncohematológico
- Author
-
Vivas Moresco, M., primary, Gonzalez Tomé, M.I., additional, Baro, M., additional, Ruiz Contreras, J., additional, and Rojo, P., additional
- Published
- 2013
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.