Search

Breast cancer is the second most common cancer worldwide, primarily affecting women, while histopathological image analysis is one of the possibile methods used to determine tumor malignancy. Regarding image analysis, the application of deep learning has become increasingly prevalent in recent years. However, a significant issue is the unbalanced nature of available datasets, with some classes having more images than others, which may impact the performance of the models due to poorer generalizability. A possible strategy to avoid this problem is downsampling the class with the most images to create a balanced dataset. Nevertheless, this approach is not recommended for small datasets as it can lead to poor model performance. Instead, techniques such as data augmentation are traditionally used to address this issue. These techniques apply simple transformations such as translation or rotation to the images to increase variability in the dataset. Another possibility is using generative adversarial networks (GANs), which can generate images from a relatively small training set. This work aims to enhance model performance in classifying histopathological images by applying data augmentation using GANs instead of traditional techniques.

The lockdown of the COVID-19 pandemic impacted physical activity (PA) levels around the world, affecting health parameters in young adults with cancer (YAC). To our knowledge, there is no evidence of the impact of the lockdown on the Spanish YAC. To analyse the changes in PA levels before, during, and after the lockdown of the YAC and its impact on health metrics in Spain, in this study, we utilized a self-reported web survey. PA levels decreased during the lockdown, and a significant increase in PA was observed after the lockdown. Moderate PA had the largest reduction (49%). Significant increases in moderate PA were noted after the lockdown (85.2%). Participants self-reported more than 9 h of sitting per day. HQoL and fatigue levels were significantly worse during the lockdown. The impact of the COVID-19 pandemic in this cohort of Spanish YAC showed a decrease in PA levels during the lockdown, affecting sedentarism, fatigue and HQoL. After lockdown, PA levels partially recovered, while HQoL and fatigue levels remained altered. This may have long-term physical effects such as cardiovascular comorbidities associated with sedentarism and psychosocial effects. It is necessary to implement strategies such as cardio-oncology rehabilitation (CORE), an intervention that can be delivered online, potentially improving participants’ health behaviours and outcomes.

The benefit of adding the antiangiogenic drug aflibercept to FOLFIRI regime in metastatic colorectal cancer (CRC) patients resistant to or progressive on an oxaliplatin-based therapy has been previously demonstrated. However, the absence of validated biomarkers to predict greater outcomes is a major challenge encountered when using antiangiogenic therapies. In this study we investigated profiles of circulating microRNAs (miRNAs) to build predictive models of response to treatment and survival. Plasma was obtained from 98 metastatic CRC patients enrolled in a clinical phase II trial before receiving FOLFIRI plus aflibercept treatment, and the circulating levels of 754 individual miRNAs were quantified using real-time PCR. A distinct signature of circulating miRNAs differentiated responder from non-responder patients. Remarkably, most of these miRNAs were found to target genes that are involved in angiogenic processes. Accordingly, some of these miRNAs had predictive value and entered in predictive models of response to therapy, progression of disease, and survival of patients treated with FOLFIRI plus aflibercept. Among these miRNAs, circulating levels of hsa-miR-33b-5p efficiently discriminated between responder and non-responder patients and predicted the risk of disease progression. Moreover, the combination of circulating VEGF-A and miR-33b-5p levels improved clinical stratification of metastatic CRC patients who were to receive FOLFIRI plus aflibercept treatment. In conclusion, our study supports circulating miRNAs as valuable biomarkers for predicting better outcomes in metastatic CRC patients treated with FOLFIRI plus aflibercept.

This article explores the use of populism by comparatively privileged groups, a specific type of populism we call the 'populism of the privileged'. Our argument is not merely that 'populisms of the privileged' are also forms of populism, but that they warrant a specific label. We first identify intersections between populism and privilege on the levels of populist actors, support for populism and beneficiaries of populism, which we call populism by, with and for the privileged. We then present a discursive conceptualization of 'populism of the privileged'. Building on this we develop analytical strategies for the study the 'populism of the privileged', zooming in on how 'the people' and 'the elite' are constructed in such populisms, their sociological directionality, the layeredness of privilege and un(der)privilege, the discursive construction of 'crisis' and 'unmet demands' and the role of discourses about populism in reproducing the claims of populisms of the privileged. [ABSTRACT FROM AUTHOR]

The situation generated by the pandemic has meant the acceleration of the ongoing hegemonic clash between the United States and China, as well as the intensification of the anti-China narrative and a deplorable wave of Sinophobia throughout the world. In this context, Taiwan has become a strategic hot spot for the development of the rhetoric of the enemy. This study analyses some of the direct consequences of the ensuing friend/foe discourses in the Taiwanese milieu. In the context of a new Cold War, certain groups of power and their media apparatuses have embarked into a race to discursively distance the country as quickly as possible from the despised global enemy, not to be dragged down by the proximity and commonalities shared with China. Moreover, social polarization within Taiwan and contempt for the internal “enemies” pose an added challenge both for the maintenance of liberal democracy and the preservation of peace and self-government on the island. These outcomes are facilitated by underlying populist and nationalist processes of identity construction and hegemonic struggle: distinct discourses re-articulating the Taiwanese identity as an underdog people and a victimized nation.

Purpose: Cancer-related fatigue (CRF) is the most common and disruptive symptom experienced by cancer survivors and because of its frequency and severity is especially worrisome in breast cancer survivors (BCS). Despite a great deal of research, the mechanisms underlying CRF have not been determined. The present study aims to describe associations between CRF in BCS and different blood biomarkers. Methods: A descriptive and cross-sectional study was conducted. A set of biomarkers assessing inflammation were measured in BCS: C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), IL-1β, IL-6, IL-8, IL-10, tumor necrosis factor (TNF); HPA axis dysfunction (cortisol), autonomic dysfunction (noradrenaline); oxidative stress (8-OH deoxyguanosine); insulin resistance markers (insulin, IGF-I, IGFBP3) and sexual hormones (estrogens, progesterone, testosterone). Results: NLR (p =.00) and cortisol (p =.02) were positive and negatively associated with CRF, respectively. The rest of the blood markers were not associated with CRF. Conclusion: Our results increase the evidence on pathophysiological mechanisms driving CRF in BCS. However, longitudinal studies are needed to explore the role of these factors as potential causal mechanisms. [ABSTRACT FROM AUTHOR]

Background Despite being highly preventable and treatable if diagnosed early, colorectal cancer (CRC) remains the second leading cause of cancer-related death in Europe. Limited information is available from the patient perspective on the persisting unmet needs of the journey of the patient with CRC.Objective To capture European metastatic CRC (mCRC) patients’ insights during the patient journey (prediagnosis; diagnosis; postdiagnosis) through a patient survey.Methods In total, 883 patients from 15 European countries participated. Participants were divided into four groups from Hungary, Poland, Serbia and ‘other European countries’ (n=103, 163, 170 and 447 patients, respectively).Results General awareness of CRC and its symptoms prediagnosis varied among groups, with patients from Poland recording the lowest levels. Screening practices and attitudes also varied; while more patients from Serbia had been invited to CRC screening (~15%) compared with the other groups, the ones not invited claimed mostly (~20%) that would not have attended if they had been invited. Whereas most patients were diagnosed within a month after the first consultation/positive screening, the percentages varied substantially being lowest among patients in Poland (~30%) and Serbia (~25%). Although CRC-related information provision varied, with most informed patients from Hungary (~90%) and least from Serbia (~50%), all groups requested an easier-to-understand language by the healthcare team. Approximately 50% of patients from Eastern Europe had to wait longer than a month to receive treatment, in contrast to ~30% from other European countries. All groups emphasised the unmet need for support from psychologists and other patients.Conclusions Our survey reveals the key aspects of the journey of the patient with mCRC and highlights the areas of similarities and differences between patients with mCRC from Eastern Europe versus those from other European countries as well as among patients from different Eastern European countries, calling for improvement particularly around awareness, screening, treatment availability, communication and support networks.

After the notoriety of the Catalan independence bid in the 2010s, the already extensive literature on Catalan nationalism has grown even further to offer multifarious explanations for the conflict over independence both within Catalonia and between Catalonia and Spain. This article draws on recent approaches incorporating populism – in its articulation with nationalism – as an essential theoretical and empirical tool to better describe the emergence and dynamics of the Catalan independence movement. The study argues that the prevailing populist construction of a sovereign 'people' in Catalonia led to a discursive struggle over the floating signifier 'democracy' between two majority blocs: the one governing Catalonia vis-à-vis the one governing Spain. This is followed by a discourse-theoretical analysis of each bloc's attempts to endow the floating signifier 'democracy' with distinctive meanings. Each bloc, acting in line with their political interests and against the will of relevant minorities within their sovereign demarcations, discursively articulated alternative interpretations of what democracy 'truly' is, thus claiming democratic legitimacy for themselves while demonizing the opponent as 'anti-democratic'. As a result, the insoluble conflict in Catalonia can largely be explained as a struggle with important ethico-political implications between two irreconcilable understandings of 'democracy': constitutional democracy versus majoritarian democracy. [ABSTRACT FROM AUTHOR]