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307 results on '"Ruiz-Camps, Isabel"'

1. Safety and effectiveness of isavuconazole in real-life non-neutropenic patients

Author

Monzó-Gallo, Patricia, Lopera, Carlos, Badía-Tejero, Ana M, Machado, Marina, García-Rodríguez, Julio, Vidal-Cortés, Pablo, Merino, Esperanza, Calderón, Jorge, Fortún, Jesús, Palacios-Baena, Zaira R., Pemán, Javier, Sanchis, Joan Roig, Aguilar-Guisado, Manuela, Gudiol, Carlota, Ramos, Juan C, Sánchez-Romero, Isabel, Martin-Davila, Pilar, López-Cortés, Luis E., Salavert, Miguel, Ruiz-Camps, Isabel, Chumbita, Mariana, Aiello, Tommaso Francesco, Peyrony, Olivier, Puerta-Alcalde, Pedro, Soriano, Alex, Marco, Francesc, and Garcia-Vidal, Carolina

Published
2024
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2. Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry

Author

Mostaghim, Anahita, Minkove, Samuel, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Eremiev-Eremiev, Simeon, Dettorre, Gino M., Fox, Laura, Tondini, Carlo, Brunet, Joan, Carmona-García, MCarmen, Lambertini, Matteo, Bower, Mark, Newsom-Davis, Thomas, Sharkey, Rachel, Pria, Alessia Dalla, Rossi, Maura, Plaja, Andrea, Salazar, Ramon, Sureda, Anna, Prat, Aleix, Michalarea, Vasiliki, Van Hemelrijck, Mieke, Sita-Lumsden, Ailsa, Bertuzzi, Alexia, Rimassa, Lorenza, Rossi, Sabrina, Rizzo, Gianpiero, Pedrazzoli, Paolo, Lee, Alvin JX, Murphy, Cian, Belessiotis, Katherine, Diamantis, Nikolaos, Mukherjee, Uma, Pommeret, Fanny, Stoclin, Annabelle, Martinez-Vila, Clara, Bruna, Riccardo, Gaidano, Gianluca, D'Avanzo, Francesca, Gennari, Alessandra, Athale, Janhavi, Eichacker, Peter, Pinato, David J., Torabi-Parizi, Parizad, and Cortellini, Alessio

Published
2024
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3. Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study

Author

Puerta-Alcalde, Pedro, Monzó-Gallo, Patricia, Aguilar-Guisado, Manuela, Ramos, Juan Carlos, Laporte-Amargós, Júlia, Machado, Marina, Martin-Davila, Pilar, Franch-Sarto, Mireia, Sánchez-Romero, Isabel, Badiola, Jon, Gómez, Lucia, Ruiz-Camps, Isabel, Yáñez, Lucrecia, Vázquez, Lourdes, Chumbita, Mariana, Marco, Francesc, Soriano, Alex, González, Pedro, Fernández-Cruz, Ana, Batlle, Montserrat, Fortún, Jesús, Guinea, Jesús, Gudiol, Carlota, García, Julio, Ruiz Pérez de Pipaón, Maite, Alastruey-Izquierdo, Ana, and Garcia-Vidal, Carolina

Published
2023
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4. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author

Evans, Joanne S, Swallow, Judith, Hanbury, Georgina, Chung, Chris, Patel, Meera, Dettorre, Gino, Belessiotis, Katherine, Saorise, Dolly, Jones, Eleanor, Apthorp, Eleanor, Moss, Charlotte, Russell, Beth, Townsend, Sarah, Jackson, Amanda, Loizidou, Angela, Piccart, Martine, Pommeret, Fanny, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Scotti, Lorenza, Marrari, Andrea, Grosso, Federica, Fusco, Vittorio, Delfanti, Sara, Rossi, Maura, Zambelli, Alberto, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Provenzano, Salvatore, Generali, Daniele, Grisanti, Salvatore, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Tucci, Marco, Berardi, Rossana, Cantini, Luca, Paoloni, Francesco, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Cortellini, Alessio, Tabernero, Josep, Mukherjee, Uma, Salazar, Ramon, Sureda, Anna, Maluquer, Clara, Ferrante, Daniela, Bower, Mark, Sharkey, Rachel, Mirallas, Oriol, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Dalla Pria, Alessia, Newsom-Davis, Thomas, Van Hemelrijck, Mieke, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Di Fazio, Giuseppina Rita, Tonini, Giuseppe, Pantano, Francesco, Bertuzzi, Alexia, Rossi, Sabrina, Brunet, Joan, Lambertini, Matteo, Pedrazzoli, Paolo, Biello, Federica, D'Avanzo, Francesca, Lee, Alvin J X, Shawe-Taylor, Marianne, Rogers, Lucy, Murphy, Cian, Cooper, Lee, Andaleeb, Ramis, Khalique, Saira, Bawany, Samira, Ahmed, Sarah, Carmona-García, M Carmen, Fort-Culillas, Roser, Liñan, Raquel, Zoratto, Federica, Rizzo, Gianpiero, Perachino, Marta, Doonga, Kris, Gaidano, Gianluca, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Pérez Criado, Ignacio, Giusti, Raffaele, Mazzoni, Francesca, Antonuzzo, Lorenzo, Santoro, Armando, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Diamantis, Nikolaos, Bertulli, Rossella, Fulgenzi, Claudia A M, D'Alessio, Antonio, Ruiz-Camps, Isabel, Saoudi-Gonzalez, Nadia, Garcia Illescas, David, Medina, Irene, Fox, Laura, Gennari, Alessandra, Aguilar-Company, Juan, and Pinato, David J

Published
2023
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5. Emergence of Delta and Omicron variants carrying resistance-associated mutations in immunocompromised patients undergoing sotrovimab treatment with long-term viral excretion

Author

Andrés, Cristina, González-Sánchez, Alejandra, Jiménez, Moraima, Márquez-Algaba, Ester, Piñana, Maria, Fernández-Naval, Candela, Esperalba, Juliana, Saubi, Narcís, Quer, Josep, Rando-Segura, Ariadna, Miarons, Marta, Codina, Maria Gema, Ruiz-Camps, Isabel, Pumarola, Tomàs, Abrisqueta, Pau, and Antón, Andrés

Published
2023
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7. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author

Evans, Joanne S, Swallow, Judith, Chung, Chris, Patel, Meera, Dettorre, Gino, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Yu, Tamara, Shawe-Taylor, Marianne, Bain, Hamish DC, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Earnshaw, Irina, Patel, Grisma, Wu, Anjui, Soosaipillai, Gehan, Cooper, Lee, Andaleeb, Ramis, Dolly, Saoirse, Apthorp, Eleanor, Srikandarajah, Krishnie, Jones, Eleanor, Van Hemelrijck, Mieke, Moss, Charlotte, Russell, Beth, Chester, John, Loizidou, Angela, Piccart, Martine, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Eremiev, Simeon, Fort-Culillas, Roser, Garcia, Isabel, Liñan, Raquel, Roqué Lloveras, Ariadna, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Pous, Anna, D'Avanzo, Francesca, Scotti, Lorenza, Krengli, Marco, Marrari, Andrea, Delfanti, Sara, Maconi, Antonio, Betti, Marta, Tonini, Giuseppe, Di Fazio, Giuseppina Rita, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Bertulli, Rossella, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Zoratto, Federica, Paoloni, Francesco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Colomba, Emeline, Pommeret, Fanny, Pinato, David J, Aguilar-Company, Juan, Ferrante, Daniela, Hanbury, Georgina, Bower, Mark, Salazar, Ramon, Mirallas, Oriol, Sureda, Anna, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Townsend, Sarah, Jackson, Amanda, Dalla Pria, Alessia, Newsom-Davis, Thomas, Handford, Jasmine, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Biello, Federica, Sinclair, Alasdair, Bawany, Samira, Khalique, Saira, Rossi, Sabrina, Rogers, Lucy, Murphy, Cian, Belessiotis, Katherine, Carmona-García, M Carmen, Sharkey, Rachel, García-Illescas, David, Rizzo, Gianpiero, Perachino, Marta, Saoudi-Gonzalez, Nadia, Doonga, Kris, Fox, Laura, Roldán, Elisa, Gaidano, Gianluca, Ruiz-Camps, Isabel, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Cantini, Luca, Zambelli, Alberto, Giusti, Raffaele, Mazzoni, Francesca, Caliman, Enrico, Santoro, Armando, Grosso, Federica, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Prat, Aleix, Tucci, Marco, Grisanti, Salvatore, Mukherjee, Uma, Diamantis, Nikolaos, Fusco, Vittorio, Generali, Daniele, Provenzano, Salvatore, Gennari, Alessandra, Tabernero, Josep, and Cortellini, Alessio

Published
2022
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8. Cellular and humoral immunogenicity of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies

Author

Jiménez, Moraima, Roldán, Elisa, Fernández-Naval, Candela, Villacampa, Guillermo, Martinez-Gallo, Mónica, Medina-Gil, Daniel, Peralta-Garzón, Soraya, Pujadas, Gemma, Hernández, Cristina, Pagès, Carlota, Gironella, Mercedes, Fox, Laura, Orti, Guillermo, Barba, Pere, Pumarola, Tomás, Cabirta, Alba, Catalá, Eva, Valentín, Mercedes, Marín-Niebla, Ana, Orfao, Alberto, González, Marcos, Campins, Magda, Ruiz-Camps, Isabel, Valcárcel, David, Bosch, Francesc, Hernández, Manuel, Crespo, Marta, Esperalba, Juliana, and Abrisqueta, Pau

Published
2022
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9. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the OnCovid retrospective, multicentre registry study

Author

Swallow, Judith, Chung, Chris, Dettorre, Gino, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Patel, Grisma, Wu, Anjui, Sinclair, Alasdair, Soosaipillai, Gehan, Jones, Eleanor, Diamantis, Nikolaos, Mukherjee, Uma, Jackson, Amanda, Piccart, Martine, Pommeret, Fanny, Colomba, Johann, Colomba-Blameble, Emeline, Prat, Aleix, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Tabernero, Josep, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Fox, Laura, Garcia Illescas, David, Mirallas, Oriol, Roldán, Elisa, Carbó, Anna, Garcia, Isabel, Wuerstlein, Rachel, Mesia, Ricard, Maluquer, Clara, D'Avanzo, Francesca, Tonini, Giuseppe, Provenzano, Salvatore, Tovazzi, Valeria, Ficorella, Corrado, Queirolo, Paola, Giusti, Raffaele, Mazzoni, Francesca, Zoratto, Federica, Tucci, Marco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Pinato, David J, Bower, Mark, Scotti, Lorenza, Patel, Meera, Colomba, Emeline, Dolly, Saoirse, Loizidou, Angela, Chester, John, Zambelli, Alberto, Dalla Pria, Alessia, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Salazar, Ramon, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Tagliamento, Marco, Pous, Anna, Sita-Lumsden, Ailsa, Srikandarajah, Krishnie, Seguí, Elia, Generali, Daniele, Grisanti, Salvatore, Pedrazzoli, Paolo, Rizzo, Gianpiero, Libertini, Michela, Moss, Charlotte, Evans, Joanne S, Russell, Beth, Harbeck, Nadia, Vincenzi, Bruno, Biello, Federica, Bertulli, Rossella, Liñan, Raquel, Rossi, Sabrina, Carmona-García, Maria Carmen, Tondini, Carlo, Baggi, Alice, Fotia, Vittoria, Parisi, Alessandro, Porzio, Giampero, Saponara, Maristella, Cruz, Claudia Andrea, García-Illescas, David, Felip, Eudald, Roqué Lloveras, Ariadna, Sharkey, Rachel, Earnshaw, Irina, Ferrante, Daniela, Gaidano, Gianluca, Patriarca, Andrea, Bruna, Riccardo, Sureda, Anna, Martinez-Vila, Clara, Sanchez de Torre, Ana, Cantini, Luca, Filetti, Marco, Rimassa, Lorenza, Chiudinelli, Lorenzo, Franchi, Michela, Krengli, Marco, Santoro, Armando, Van Hemelrijck, Mieke, Newsom-Davis, Thomas, Gennari, Alessandra, and Cortellini, Alessio

Published
2021
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10. Pseudomonas aeruginosa Bloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy

Author

Royo-Cebrecos, Cristina, primary, Laporte-Amargós, Júlia, additional, Peña, Marta, additional, Ruiz-Camps, Isabel, additional, Garcia-Vidal, Carolina, additional, Abdala, Edson, additional, Oltolini, Chiara, additional, Akova, Murat, additional, Montejo, Miguel, additional, Mikulska, Malgorzata, additional, Martín-Dávila, Pilar, additional, Herrera, Fabián, additional, Gasch, Oriol, additional, Drgona, Lubos, additional, Morales, Hugo Manuel Paz, additional, Brunel, Anne-Sophie, additional, García, Estefanía, additional, Isler, Burcu, additional, Kern, Winfried V., additional, Palacios-Baena, Zaira R., additional, de la Calle, Guillermo Maestr, additional, Montero, Maria Milagro, additional, Kanj, Souha S., additional, Sipahi, Oguz R., additional, Calik, Sebnem, additional, Márquez-Gómez, Ignacio, additional, Marin, Jorge I., additional, Gomes, Marisa Z. R., additional, Hemmatii, Philipp, additional, Araos, Rafael, additional, Peghin, Maddalena, additional, Del Pozo, Jose L., additional, Yáñez, Lucrecia, additional, Tilley, Robert, additional, Manzur, Adriana, additional, Novo, Andrés, additional, Carratalà, Jordi, additional, and Gudiol, Carlota, additional

Published
2024
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12. Recommendations for screening, monitoring, prevention, and prophylaxis of infections in adult and pediatric patients receiving CAR T-cell therapy: a position paper

Author

Los-Arcos, Ibai, Iacoboni, Gloria, Aguilar-Guisado, Manuela, Alsina-Manrique, Laia, Díaz de Heredia, Cristina, Fortuny-Guasch, Claudia, García-Cadenas, Irene, García-Vidal, Carolina, González-Vicent, Marta, Hernani, Rafael, Kwon, Mi, Machado, Marina, Martínez-Gómez, Xavier, Maldonado, Valentín Ortiz, Pla, Carolina Pinto, Piñana, José Luis, Pomar, Virginia, Reguera-Ortega, Juan Luis, Salavert, Miguel, Soler-Palacín, Pere, Vázquez-López, Lourdes, Barba, Pere, and Ruiz-Camps, Isabel

Published
2021
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14. Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Network for Research in Infectious Diseases (REIPI) and the Spanish Society of Haematology and Haemotherapy (SEHH) on the management of febrile neutropenia in patients with hematological malignancies

Author

Gudiol, Carlota, Aguilar-Guisado, Manuela, Azanza, José Ramón, Candel, Francisco Javier, Cantón, Rafael, Carratalà, Jordi, Garcia-Vidal, Carolina, Jarque, Isidro, Lizasoain, Manuel, Gil-Bermejo, José Molina, Ruiz-Camps, Isabel, Sánchez-Ortega, Isabel, Solano, Carlos, Suárez-Lledó, María, Vázquez, Lourdes, and de la Cámara, Rafael

Published
2020
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15. Impact of SARS-CoV-2 vaccines and recent chemotherapy on COVID-19 morbidity and mortality in patients with soft tissue sarcoma: an analysis from the OnCovid registry

Author

Vincenzi, Bruno, primary, Cortellini, Alessio, additional, Mazzocca, Alessandro, additional, Orlando, Sarah, additional, Romandini, Davide, additional, Aguilar-Company, Juan, additional, Ruiz-Camps, Isabel, additional, Valverde Morales, Claudia, additional, Eremiev-Eremiev, Simeon, additional, Tondini, Carlo, additional, Brunet, Joan, additional, Bertulli, Rossella, additional, Provenzano, Salvatore, additional, Bower, Mark, additional, Generali, Daniele, additional, Salazar, Ramon, additional, Sureda, Anna, additional, Prat, Aleix, additional, Vasiliki, Michalarea, additional, Van Hemelrijck, Mieke, additional, Sita-Lumsden, Ailsa, additional, Bertuzzi, Alexia, additional, Rossi, Sabrina, additional, Jackson, Amanda, additional, Grosso, Federica, additional, Lee, Alvin J. X., additional, Murphy, Cian, additional, Belessiotis, Katherine, additional, Mukherjee, Uma, additional, Pommeret, Fanny, additional, Loizidou, Angela, additional, Gaidano, Gianluca, additional, Dettorre, Gino M., additional, Grisanti, Salvatore, additional, Tucci, Marco, additional, Fulgenzi, Claudia A. M., additional, Gennari, Alessandra, additional, Napolitano, Andrea, additional, and Pinato, David J., additional

Published
2024
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16. Impact of Antibacterial Prophylaxis on Morbidity-Mortality of Patients with Myeloid Neoplasms Treated with Non-Intensive Venetoclax Combinations

Author

Garrido Paniagua, Sara, primary, Novoa Jáuregui, Sandra, additional, Molero Yordi, Antonieta, additional, Vall-llovera Calmet, Ferran, additional, Valencia Becerra, Laura Camila, additional, Escolano Escobar, Cristian, additional, Arnaiz Martín, Irene, additional, Ocampo Martínez, Raquel, additional, Masana Flores, Elena, additional, González-Santillana, Clara Isabel, additional, Pacheco Reyes, Alfredo, additional, Capellán García, Raquel, additional, Aceituno Caneiro, Marta, additional, Coll, Rosa, additional, Albasanz-Puig, Adaia, additional, Ruiz Camps, Isabel, additional, Alonso-Martínez, Carla, additional, Pérez-González, Ana, additional, Sola Soto, Maria, additional, Fox, Maria Laura, additional, Valcarcel, David, additional, and Salamero, Olga, additional

Published
2023
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18. Corrigendum to “Safety and effectiveness of isavuconazole in real-life non-neu tropenic patients” [International Journal of Infectious Diseases 144 (2024) 107070]

Author

Monzó-Gallo, Patricia, Lopera, Carlos, Badía-Tejero, Ana M., Machado, Marina, García-Rodríguez, Julio, Vidal-Cortés, Pablo, Merino, Esperanza, Calderón, Jorge, Fortún, Jesús, Palacios-Baena, Zaira R., Pemán, Javier, Sanchis, Joan Roig, Aguilar-Guisado, Manuela, Gudiol, Carlota, Ramos, Juan C., Sánchez-Romero, Isabel, Martin-Davila, Pilar, López-Cortés, Luis E., Salavert, Miguel, Ruiz-Camps, Isabel, Chumbita, Mariana, Aiello, Tommaso Francesco, Peyrony, Olivier, Puerta-Alcalde, Pedro, Soriano, Alex, Marco, Francesc, and Garcia-Vidal, Carolina

Published
2024
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19. Executive summary of clinical practice guideline for the management of invasive diseases caused by Aspergillus: 2018 Update by the GEMICOMED-SEIMC/REIPI

Author

Garcia-Vidal, Carolina, Alastruey-Izquierdo, Ana, Aguilar-Guisado, Manuela, Carratalà, Jordi, Castro, Carmen, Fernández-Ruiz, Mario, Aguado, José María, Fernández, José María, Fortún, Jesús, Garnacho-Montero, José, Gavaldà, Joan, Gudiol, Carlota, Guinea, Jesús, Gómez-López, Alicia, Muñoz, Patricia, Pemán, Javier, Rovira, Montserrat, Ruiz-Camps, Isabel, and Cuenca-Estrella, Manuel

Published
2019
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21. Adenovirus-induced hemorrhagic cystitis after CD19-targeted chimeric antigen receptor T-cell therapy in a patient with large B-cell lymphoma

Author

Medina, Irene, primary, Carpio, Cecilia, additional, Ruiz-Camps, Isabel, additional, Albasanz-Puig, Adaia, additional, Lopez-Godino, Oriana, additional, Esperalba, Juliana, additional, Beas, Francisco, additional, Sanchez-Salinas, Mario, additional, Iacoboni, Gloria, additional, and Barba, Pere, additional

Published
2023
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24. Healthcare-Associated Mycobacterium bovis–Bacille Calmette-Guérin (BCG) Infection in Cancer Patients Without Prior BCG Instillation

Author

Meije, Yolanda, Martínez-Montauti, Joaquín, Caylà, Joan A., Loureiro, Jose, Ortega, Lucía, Clemente, Mercedes, Sanz, Xavier, Ricart, Montserrat, Santomà, María J., Coll, Pere, Seirra, Montserrat, Calsina, Marta, Vaqué, Montserrat, Ruiz-Camps, Isabel, López-Sánchez, Cristina, Montes, Mar, Ayestarán, Ana, Carratalà, Jordi, and Orcau, Àngels

Published
2017

25. Kinetics of cellular and humoral immunogenicity and effectiveness of SARS‐CoV ‐2 booster vaccination in hematologic neoplasms

Author

Jiménez, Moraima, primary, Fernández‐Naval, Candela, additional, Navarro, Víctor, additional, Novoa, Sandra, additional, Martinez‐Gallo, Mónica, additional, Medina, Daniel, additional, Andrés, Cristina, additional, Antón, Andrés, additional, Peralta, Soraya, additional, Pujadas, Gemma, additional, Hernández, Cristina, additional, Pagès, Carlota, additional, Roldán, Elisa, additional, Pumarola, Tomás, additional, Gironella, Mercedes, additional, Ruiz‐Camps, Isabel, additional, Martínez‐Gómez, Xavier, additional, Valcárcel, David, additional, Hernández, Manuel, additional, Bosch, Francesc, additional, Crespo, Marta, additional, Esperalba, Juliana, additional, and Abrisqueta, Pau, additional

Published
2023
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26. Recommendations on the use of azole antifungals in hematology-oncology patients

Author

Azanza, José Ramón, primary, Mensa, José, additional, Barberán, José, additional, Vázquez, Lourdes, additional, Pérez de Oteyza, Jaime, additional, Kwon, Mi, additional, Yáñez, Lucrecia, additional, Aguado, José María, additional, Cubillo Gracian, Antonio, additional, Solano, Carlos, additional, Ruiz Camps, Isabel, additional, Fortún, Jesús, additional, Salavert Lletí, Miguel, additional, Gudiol, Carlota, additional, Olave Rubio, Teresa, additional, García-Vidal, Carolina, additional, Rovira Tarrats, Montserrat, additional, Suárez-Lledó Grande, María, additional, González-Sierra, Pedro, additional, and Dueñas Gutiérrez, Carlos, additional

Published
2023
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27. Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer

Author

Pinato, David J., primary, Zambelli, Alberto, primary, Aguilar-Company, Juan, primary, Bower, Mark, primary, Sng, Christopher C.T., primary, Salazar, Ramon, primary, Bertuzzi, Alexia, primary, Brunet, Joan, primary, Mesia, Ricard, primary, Seguí, Elia, primary, Biello, Federica, primary, Generali, Daniele, primary, Grisanti, Salvatore, primary, Rizzo, Gianpiero, primary, Libertini, Michela, primary, Maconi, Antonio, primary, Harbeck, Nadia, primary, Vincenzi, Bruno, primary, Bertulli, Rossella, primary, Ottaviani, Diego, primary, Carbó, Anna, primary, Bruna, Riccardo, primary, Benafif, Sarah, primary, Marrari, Andrea, primary, Wuerstlein, Rachel, primary, Carmona-Garcia, M. Carmen, primary, Chopra, Neha, primary, Tondini, Carlo, primary, Mirallas, Oriol, primary, Tovazzi, Valeria, primary, Betti, Marta, primary, Provenzano, Salvatore, primary, Fotia, Vittoria, primary, Cruz, Claudia Andrea, primary, Dalla Pria, Alessia, primary, D'Avanzo, Francesca, primary, Evans, Joanne S., primary, Saoudi-Gonzalez, Nadia, primary, Felip, Eudald, primary, Galazi, Myria, primary, Garcia-Fructuoso, Isabel, primary, Lee, Alvin J.X., primary, Newsom-Davis, Thomas, primary, Patriarca, Andrea, primary, García-Illescas, David, primary, Reyes, Roxana, primary, Dileo, Palma, primary, Sharkey, Rachel, primary, Wong, Yien Ning Sophia, primary, Ferrante, Daniela, primary, Marco-Hernández, Javier, primary, Sureda, Anna, primary, Maluquer, Clara, primary, Ruiz-Camps, Isabel, primary, Gaidano, Gianluca, primary, Rimassa, Lorenza, primary, Chiudinelli, Lorenzo, primary, Izuzquiza, Macarena, primary, Cabirta, Alba, primary, Franchi, Michela, primary, Santoro, Armando, primary, Prat, Aleix, primary, Tabernero, Josep, primary, Gennari, Alessandra, primary, Avanzi, Gian Carlo, primary, Bellan, Mattia, primary, Castello, Luigi Mario, primary, Martinez, Maria, primary, Mollà, Meritxell, primary, Pirisi, Mario, primary, Scotti, Lorenza, primary, and Swallow, Judith, primary

Published
2023
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28. Supplementary Data from Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer

Author

Pinato, David J., primary, Zambelli, Alberto, primary, Aguilar-Company, Juan, primary, Bower, Mark, primary, Sng, Christopher C.T., primary, Salazar, Ramon, primary, Bertuzzi, Alexia, primary, Brunet, Joan, primary, Mesia, Ricard, primary, Seguí, Elia, primary, Biello, Federica, primary, Generali, Daniele, primary, Grisanti, Salvatore, primary, Rizzo, Gianpiero, primary, Libertini, Michela, primary, Maconi, Antonio, primary, Harbeck, Nadia, primary, Vincenzi, Bruno, primary, Bertulli, Rossella, primary, Ottaviani, Diego, primary, Carbó, Anna, primary, Bruna, Riccardo, primary, Benafif, Sarah, primary, Marrari, Andrea, primary, Wuerstlein, Rachel, primary, Carmona-Garcia, M. Carmen, primary, Chopra, Neha, primary, Tondini, Carlo, primary, Mirallas, Oriol, primary, Tovazzi, Valeria, primary, Betti, Marta, primary, Provenzano, Salvatore, primary, Fotia, Vittoria, primary, Cruz, Claudia Andrea, primary, Dalla Pria, Alessia, primary, D'Avanzo, Francesca, primary, Evans, Joanne S., primary, Saoudi-Gonzalez, Nadia, primary, Felip, Eudald, primary, Galazi, Myria, primary, Garcia-Fructuoso, Isabel, primary, Lee, Alvin J.X., primary, Newsom-Davis, Thomas, primary, Patriarca, Andrea, primary, García-Illescas, David, primary, Reyes, Roxana, primary, Dileo, Palma, primary, Sharkey, Rachel, primary, Wong, Yien Ning Sophia, primary, Ferrante, Daniela, primary, Marco-Hernández, Javier, primary, Sureda, Anna, primary, Maluquer, Clara, primary, Ruiz-Camps, Isabel, primary, Gaidano, Gianluca, primary, Rimassa, Lorenza, primary, Chiudinelli, Lorenzo, primary, Izuzquiza, Macarena, primary, Cabirta, Alba, primary, Franchi, Michela, primary, Santoro, Armando, primary, Prat, Aleix, primary, Tabernero, Josep, primary, Gennari, Alessandra, primary, Avanzi, Gian Carlo, primary, Bellan, Mattia, primary, Castello, Luigi Mario, primary, Martinez, Maria, primary, Mollà, Meritxell, primary, Pirisi, Mario, primary, Scotti, Lorenza, primary, and Swallow, Judith, primary

Published
2023
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29. SARS-CoV-2 omicron (B.1.1.529)-related COVID-19 sequelae in vaccinated and unvaccinated patients with cancer: results from the OnCovid registry

Author

Cortellini, Alessio, primary, Tabernero, Josep, additional, Mukherjee, Uma, additional, Salazar, Ramon, additional, Sureda, Anna, additional, Maluquer, Clara, additional, Ferrante, Daniela, additional, Bower, Mark, additional, Sharkey, Rachel, additional, Mirallas, Oriol, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, Mesia, Ricard, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Van Hemelrijck, Mieke, additional, Sita-Lumsden, Ailsa, additional, Apthorp, Eleanor, additional, Vincenzi, Bruno, additional, Di Fazio, Giuseppina Rita, additional, Tonini, Giuseppe, additional, Pantano, Francesco, additional, Bertuzzi, Alexia, additional, Rossi, Sabrina, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, D'Avanzo, Francesca, additional, Lee, Alvin J X, additional, Shawe-Taylor, Marianne, additional, Rogers, Lucy, additional, Murphy, Cian, additional, Cooper, Lee, additional, Andaleeb, Ramis, additional, Khalique, Saira, additional, Bawany, Samira, additional, Ahmed, Sarah, additional, Carmona-García, M Carmen, additional, Fort-Culillas, Roser, additional, Liñan, Raquel, additional, Zoratto, Federica, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Doonga, Kris, additional, Gaidano, Gianluca, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Martinez-Vila, Clara, additional, Pérez Criado, Ignacio, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Antonuzzo, Lorenzo, additional, Santoro, Armando, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Diamantis, Nikolaos, additional, Bertulli, Rossella, additional, Fulgenzi, Claudia A M, additional, D'Alessio, Antonio, additional, Ruiz-Camps, Isabel, additional, Saoudi-Gonzalez, Nadia, additional, Garcia Illescas, David, additional, Medina, Irene, additional, Fox, Laura, additional, Gennari, Alessandra, additional, Aguilar-Company, Juan, additional, Pinato, David J, additional, Evans, Joanne S, additional, Swallow, Judith, additional, Hanbury, Georgina, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Belessiotis, Katherine, additional, Saorise, Dolly, additional, Jones, Eleanor, additional, Moss, Charlotte, additional, Russell, Beth, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Pommeret, Fanny, additional, Colomba-Blameble, Emeline, additional, Prat, Aleix, additional, Cruz, Claudia A, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Felip, Eudald, additional, Scotti, Lorenza, additional, Marrari, Andrea, additional, Grosso, Federica, additional, Fusco, Vittorio, additional, Delfanti, Sara, additional, Rossi, Maura, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Libertini, Michela, additional, Provenzano, Salvatore, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Filetti, Marco, additional, Tucci, Marco, additional, Berardi, Rossana, additional, Cantini, Luca, additional, Paoloni, Francesco, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, and Tagliamento, Marco, additional

Published
2023
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30. Breakthrough invasive fungal infection among patients with haematologic malignancies: A national, prospective, and multicentre study

Author

Gilead Sciences, Instituto de Salud Carlos III, European Commission, Puerta-Alcalde, Pedro, Monzó-Gallo, Patricia, Aguilar Guisado, Manuela, Ramos, Juan Carlos, Laporte-Amargós, Júlia, Machado, Marina, Martín-Dávila, Pilar, Franch-Sarto, Mireia, Sánchez-Romero, Isabel, Badiola, Jon, Gómez, Lucia, Ruiz-Camps, Isabel, Yáñez, Lucrecia, Vázquez, Lourdes, Chumbita, Mariana, Marco, Francesc, Soriano, Álex, González, Pedro, Fernández-Cruz, Ana, Batlle, Montserrat, Fortún, Jesús, Guinea, Jesús, Gudiol, Carlota, García, Julio, Ruiz Pérez de Pipaón, Maite, Alastruey-Izquierdo, Ana, García-Vidal, Carolina, Gilead Sciences, Instituto de Salud Carlos III, European Commission, Puerta-Alcalde, Pedro, Monzó-Gallo, Patricia, Aguilar Guisado, Manuela, Ramos, Juan Carlos, Laporte-Amargós, Júlia, Machado, Marina, Martín-Dávila, Pilar, Franch-Sarto, Mireia, Sánchez-Romero, Isabel, Badiola, Jon, Gómez, Lucia, Ruiz-Camps, Isabel, Yáñez, Lucrecia, Vázquez, Lourdes, Chumbita, Mariana, Marco, Francesc, Soriano, Álex, González, Pedro, Fernández-Cruz, Ana, Batlle, Montserrat, Fortún, Jesús, Guinea, Jesús, Gudiol, Carlota, García, Julio, Ruiz Pérez de Pipaón, Maite, Alastruey-Izquierdo, Ana, and García-Vidal, Carolina

Abstract

[Objectives] We describe the current epidemiology, causes, and outcomes of breakthrough invasive fungal infections (BtIFI) in patients with haematologic malignancies., [Methods] BtIFI in patients with ≥ 7 days of prior antifungals were prospectively diagnosed (36 months across 13 Spanish hospitals) according to revised EORTC/MSG definitions., [Results] 121 episodes of BtIFI were documented, of which 41 (33.9%) were proven; 53 (43.8%), probable; and 27 (22.3%), possible. The most frequent prior antifungals included posaconazole (32.2%), echinocandins (28.9%) and fluconazole (24.8%)—mainly for primary prophylaxis (81%). The most common haematologic malignancy was acute leukaemia (64.5%), and 59 (48.8%) patients had undergone a hematopoietic stem-cell transplantation. Invasive aspergillosis, principally caused by non-fumigatus Aspergillus, was the most frequent BtIFI with 55 (45.5%) episodes recorded, followed by candidemia (23, 19%), mucormycosis (7, 5.8%), other moulds (6, 5%) and other yeasts (5, 4.1%). Azole resistance/non-susceptibility was commonly found. Prior antifungal therapy widely determined BtIFI epidemiology. The most common cause of BtIFI in proven and probable cases was the lack of activity of the prior antifungal (63, 67.0%). At diagnosis, antifungal therapy was mostly changed (90.9%), mainly to liposomal amphotericin-B (48.8%). Overall, 100-day mortality was 47.1%; BtIFI was either the cause or an essential contributing factor to death in 61.4% of cases., [Conclusions] BtIFI are mainly caused by non-fumigatus Aspergillus, non-albicans Candida, Mucorales and other rare species of mould and yeast. Prior antifungals determine the epidemiology of BtIFI. The exceedingly high mortality due to BtIFI warrants an aggressive diagnostic approach and early initiation of broad-spectrum antifungals different than those previously used.

Published
2023

33. Clinical Impact of Sars-Cov-2 Vaccination in COVID-19 Outcomes in Patients Diagnosed with Hematologic Malignancies: Real-World Evidence of Two Years of Pandemic

Author

Jiménez, Moraima, primary, Novoa Jáuregui, Sandra, additional, Fernández-Naval, Candela, additional, Bosch Schips, Marc, additional, Muzio, Sofía, additional, Navarro Garcés, Víctor, additional, Andrés, Cristina, additional, Martínez-Gallo, Mónica, additional, Antón, Andrés, additional, Cabirta, Alba, additional, Serna, Angel, additional, Medina, Daniel, additional, Peralta, Soraya, additional, Pujadas, Gemma, additional, Hernandez, Cristina, additional, Pagès, Carlota, additional, Pumarola, Tomás, additional, Valentín, Mercedes, additional, Valcárcel, David, additional, Hernández, Manuel, additional, Ruiz-Camps, Isabel, additional, Crespo, Marta, additional, Esperalba, Juliana, additional, Abrisqueta, Pau, additional, and Bosch, Francesc, additional

Published
2022
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35. Pseudomonas aeruginosa Bloodstream Infections in Patients with Cancer: Differences between Patients with Hematological Malignancies and Solid Tumors

Author

Royo-Cebrecos, Cristina, Laporte-Amargós, Julia, Peña, Marta, Ruiz-Camps, Isabel, Puerta-Alcalde, Pedro, Abdala, Edson, Oltolini, Chiara, Akova, Murat, Montejo, Miguel, Mikulska, Malgorzata, Martín-Dávila, Pilar, Herrera, Fabian, Gasch, Oriol, Drgona, Lubos, Morales, Hugo Manuel Paz, Brunel, Anne-Sophie, García, Estefanía, Isler, Burcu, Kern, Winfried V, Palacios-Baena, Zaira R, de la Calle, Guillermo Maestro, Montero, Maria Milagro, Kanj, Souha S, Sipahi, Oguz R, Calik, Sebnem, Márquez-Gómez, Ignacio, Marin, Jorge I, Gomes, Marisa Z R, Hemmatti, Philipp, Araos, Rafael, Peghin, Maddalena, Del Pozo, José Luis, Yáñez, Lucrecia, Tilley, Robert, Manzur, Adriana, Novo, Andrés, Carratalà, Jordi, Gudiol, Carlota, IRONIC study group, and Universidad de Cantabria

Subjects
Microbiology (medical), Adult, Neutropenic Patients, Pseudomonas aeruginosa, bacteremia, bloodstream infection, cancer, solid tumor, hematologic malignancy, Resistance, Gram-Negative Bacilli, Bacteremia, Bloodstream infection, Immunology and Allergy, Risk-Factors, Hematologic malignanc, Mortality, Càncer, Molecular Biology, Tumors, Cancer, General Immunology and Microbiology, Solid tumor, Infectious Diseases, Therapy
Abstract

Objectives: To assess the clinical features and outcomes of Pseudomonas aeruginosa bloodstream infection (PA BSI) in neutropenic patients with hematological malignancies (HM) and with solid tumors (ST), and identify the risk factors for 30-day mortality. Methods: We performed a large multicenter, retrospective cohort study including onco-hematological neutropenic patients with PA BSI conducted across 34 centers in 12 countries (January 2006-May 2018). Episodes occurring in hematologic patients were compared to those developing in patients with ST. Risk factors associated with 30-day mortality were investigated in both groups. Results: Of 1217 episodes of PA BSI, 917 occurred in patients with HM and 300 in patients with ST. Hematological patients had more commonly profound neutropenia (0.1 x 10(9) cells/mm) (67% vs. 44.6%; p < 0.001), and a high risk Multinational Association for Supportive Care in Cancer (MASCC) index score (32.2% vs. 26.7%; p = 0.05). Catheter-infection (10.7% vs. 4.7%; p = 0.001), mucositis (2.4% vs. 0.7%; p = 0.042), and perianal infection (3.6% vs. 0.3%; p = 0.001) predominated as BSI sources in the hematological patients, whereas pneumonia (22.9% vs. 33.7%; p < 0.001) and other abdominal sites (2.8% vs. 6.3%; p = 0.006) were more common in patients with ST. Hematological patients had more frequent BSI due to multidrug-resistant P. aeruginosa (MDRPA) (23.2% vs. 7.7%; p < 0.001), and were more likely to receive inadequate initial antibiotic therapy (IEAT) (20.1% vs. 12%; p < 0.001). Patients with ST presented more frequently with septic shock (45.8% vs. 30%; p < 0.001), and presented worse outcomes, with increased 7-day (38% vs. 24.2%; p < 0.001) and 30-day (49% vs. 37.3%; p < 0.001) case-fatality rates. Risk factors for 30-day mortality in hematologic patients were high risk MASCC index score, IEAT, pneumonia, infection due to MDRPA, and septic shock. Risk factors for 30-day mortality in patients with ST were high risk MASCC index score, IEAT, persistent BSI, and septic shock. Therapy with granulocyte colony-stimulating factor was associated with survival in both groups. Conclusions: The clinical features and outcomes of PA BSI in neutropenic cancer patients showed some differences depending on the underlying malignancy. Considering these differences and the risk factors for mortality may be useful to optimize their therapeutic management. Among the risk factors associated with overall mortality, IEAT and the administration of granulocyte colony-stimulating factor were the only modifiable variables., ESCMID Study Group for Immunocompromised Hosts (ESGICH); Spanish Network for Research in Infectious Diseases; Rio Hortega program of the Instituto de Salud Carlos III; ESCMID Study Group for Bloodstream Infections, Endocarditis, and Sepsis (ESGBIES), We thank the ESCMID Study Group for Bloodstream Infections, Endocarditis, and Sepsis (ESGBIES) and the ESCMID Study Group for Immunocompromised Hosts (ESGICH) for supporting the study. We thank the Centres de Recerca de Catalunya (CERCA) Program and Generalitat de Catalunya for the institutional support. We thank the Spanish Network for Research in Infectious Diseases and the Rio Hortega program of the Instituto de Salud Carlos III for the financial support of pre-doctoral student J. Laporte-Amargos and A. Bergas.

Published
2022

36. Pseudomonas aeruginosa Bloodstream Infections in Patients with Cancer: Differences between Patients with Hematological Malignancies and Solid Tumors

Author

Royo-Cebrecos, Cristina, primary, Laporte-Amargós, Julia, additional, Peña, Marta, additional, Ruiz-Camps, Isabel, additional, Puerta-Alcalde, Pedro, additional, Abdala, Edson, additional, Oltolini, Chiara, additional, Akova, Murat, additional, Montejo, Miguel, additional, Mikulska, Malgorzata, additional, Martín-Dávila, Pilar, additional, Herrera, Fabian, additional, Gasch, Oriol, additional, Drgona, Lubos, additional, Morales, Hugo Manuel Paz, additional, Brunel, Anne-Sophie, additional, García, Estefanía, additional, Isler, Burcu, additional, Kern, Winfried V., additional, Palacios-Baena, Zaira R., additional, de la Calle, Guillermo Maestro, additional, Montero, Maria Milagro, additional, Kanj, Souha S., additional, Sipahi, Oguz R., additional, Calik, Sebnem, additional, Márquez-Gómez, Ignacio, additional, Marin, Jorge I., additional, Gomes, Marisa Z. R., additional, Hemmatti, Philipp, additional, Araos, Rafael, additional, Peghin, Maddalena, additional, del Pozo, José Luis, additional, Yáñez, Lucrecia, additional, Tilley, Robert, additional, Manzur, Adriana, additional, Novo, Andrés, additional, Carratalà, Jordi, additional, and Gudiol, Carlota, additional

Published
2022
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37. Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer

Author

Pinato, David J., primary, Ferrante, Daniela, additional, Aguilar-Company, Juan, additional, Bower, Mark, additional, Salazar, Ramon, additional, Mirallas, Oriol, additional, Sureda, Anna, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Maluquer, Clara, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, Lee, Alvin J.X., additional, Sng, Christopher C.T., additional, Liñan, Raquel, additional, Rossi, Sabrina, additional, Carmona-García, M.Carmen, additional, Sharkey, Rachel, additional, Eremiev, Simeon, additional, Rizzo, Gianpiero, additional, Bain, Hamish DC., additional, Yu, Tamara, additional, Cruz, Claudia A., additional, Perachino, Marta, additional, Saoudi-Gonzalez, Nadia, additional, Fort-Culillas, Roser, additional, Doonga, Kris, additional, Fox, Laura, additional, Roldán, Elisa, additional, Zoratto, Federica, additional, Gaidano, Gianluca, additional, Ruiz-Camps, Isabel, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Shawe-Taylor, Marianne, additional, Fusco, Vittorio, additional, Martinez-Vila, Clara, additional, Berardi, Rossana, additional, Filetti, Marco, additional, Mazzoni, Francesca, additional, Santoro, Armando, additional, Delfanti, Sara, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Prat, Aleix, additional, Tabernero, Josep, additional, Gennari, Alessandra, additional, Cortellini, Alessio, additional, Pinato, David J., additional, Evans, Joanne S., additional, Swallow, Judith, additional, Hanbury, Georgina, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Lee, Alvin JX., additional, Sng, Christopher CT., additional, Sinclair, Alasdair, additional, Cooper, Lee, additional, Rogers, Lucy, additional, Belessiotis, Katherine, additional, Murphy, Cian, additional, Bawany, Samira, additional, Khalique, Saira, additional, Andaleeb, Ramis, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Dolly, Saorise, additional, Sita-Lumsde, Ailsa, additional, Apthorp, Eleanor, additional, Jones, Eleanor, additional, Van Hemelrijck, Mieke, additional, Moss, Charlotte, additional, Russell, Beth, additional, Diamantis, Nikolaos, additional, Mukherjee, Uma, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Garcia Illescas, David, additional, Saoudi, Nadia, additional, Carmona Garcia, MCarmen, additional, Fort-Culillas, Robert, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Mesia, Ricard, additional, Felip, Eudald, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, D’Avanzo, Francesca, additional, Scotti, Lorenza, additional, Krengly, Marco, additional, Marrari, Andrea, additional, Grosso, Federica, additional, Maconi, Antonio, additional, Betti, Marta, additional, Vincenzi, Bruno, additional, Tonini, Giuseppe, additional, Zambelli, Alberto, additional, Tondini, Carlo, additional, Fotia, Vittoria, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Libertini, Michela, additional, Bertulli, Rossella, additional, Provenzano, Salvatore, additional, Generali, Daniele, additional, Grisanti, Salvatore, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Giusti, Raffaele, additional, Tucci, Marco, additional, Cantini, Luca, additional, Paoloni, Francesco, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Pommeret, Fanny, additional, and Colomba, Emeline, additional

Published
2022
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39. Epidemiology and prognosis of candidaemia in elderly patients

Author

Ramos‐Martínez, Antonio, Vicente‐López, Natalia, Sánchez‐Romero, Isabel, Padilla, Belén, Merino‐Amador, Paloma, Garnacho‐Montero, José, Ruiz‐Camps, Isabel, Montejo, Miguel, Salavert, Miguel, Mensa, José, Cuenca‐Estrella, Manuel, Muñoz, Patricia, Guinea, Jesús, Paño Pardo, José Ramón, García‐Rodríguez, Julio, Cerrada, Carlos García, Fortún, Jesús, Martín, Pilar, Gómez, Elia, Ryan, Pablo, Campelo, Carolina, de los Santos Gil, Ignacio, Buendía, Ventura, Gorricho, Beatriz Perez, Alonso, Mercedes, Sanz, Francisca Sanz, Aguado, José María, Romo, Fernando González, Gorgolas, Miguel, Gadea, Ignacio, Losa, Juan Emilio, Delgado‐Iribarren, Alberto, Romero, Yolanda, Zaragoza, Oscar, Rodriguez‐Baño, Jesús, Suarez, Ana Isabel, Loza, Ana, Aller García, Ana Isabel, Martín‐Mazuelos, Estrella, Pérez de Pipaón, Maite Ruiz, Ortiz, Carlos, Chávez, Mónica, Maroto, Fernando L., Salavert, Miguel, Pemán, Javier, Blanquer, José, Navarro, David, Camarena, Juan José, Zaragoza, Rafael, Abril, Vicente, Gimeno, Concepción, Hernáez, Silvia, Ezpeleta, Guillermo, Bereciartua, Elena, Hernández Almaraz, José L., Montejo, Miguel, Rivas, Rosa Ana, Ayarza, Rafael, Planes, Ana Mª, Almirante, Benito, Almela, Manel, Gurgui, Mercè, Sánchez‐Reus, Ferran, Martinez‐Montauti, Joaquin, Sierra, Montserrat, Horcajada, Juan Pablo, Sorli, Luisa, Gómez, Julià, Gené, Amadeu, Urrea, Mireia, Valerio, Maricela, Díaz‐Martín, Ana, Puchades, Francesc, and Mularoni, Alessandra

Published
2017
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40. Recommendations on the use of azole antifungals in hematology-oncology patients.

Author

Ramón Azanza, José, Mensa, José, Barberán, José, Vázquez, Lourdes, Pérez de Oteyza, Jaime, Kwon, Mi, Yáñez, Lucrecia, María Aguado, José, Cubillo Gracian, Antonio, Solano, Carlos, Ruiz Camps, Isabel, Fortún, Jesús, Lletí, Miguel Salavert, Gudiol, Carlota, Olave Rubio, Teresa, García-Vidal, Carolina, Rovira Tarrats, Montserrat, Suárez-Lledó Grande, María, González-Sierra, Pedro, and Dueñas Gutiérrez, Carlos

Subjects
AZOLES, ANTIFUNGAL agents, HEMATOLOGY, ARSENIC, VENETOCLAX
Abstract

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Published
2023
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42. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author

Pinato, David J, primary, Aguilar-Company, Juan, additional, Ferrante, Daniela, additional, Hanbury, Georgina, additional, Bower, Mark, additional, Salazar, Ramon, additional, Mirallas, Oriol, additional, Sureda, Anna, additional, Plaja, Andrea, additional, Cucurull, Marc, additional, Mesia, Ricard, additional, Townsend, Sarah, additional, Jackson, Amanda, additional, Dalla Pria, Alessia, additional, Newsom-Davis, Thomas, additional, Handford, Jasmine, additional, Sita-Lumsden, Ailsa, additional, Apthorp, Eleanor, additional, Vincenzi, Bruno, additional, Bertuzzi, Alexia, additional, Brunet, Joan, additional, Lambertini, Matteo, additional, Maluquer, Clara, additional, Pedrazzoli, Paolo, additional, Biello, Federica, additional, Sinclair, Alasdair, additional, Bawany, Samira, additional, Khalique, Saira, additional, Rossi, Sabrina, additional, Rogers, Lucy, additional, Murphy, Cian, additional, Belessiotis, Katherine, additional, Carmona-García, M Carmen, additional, Sharkey, Rachel, additional, García-Illescas, David, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Saoudi-Gonzalez, Nadia, additional, Doonga, Kris, additional, Fox, Laura, additional, Roldán, Elisa, additional, Gaidano, Gianluca, additional, Ruiz-Camps, Isabel, additional, Bruna, Riccardo, additional, Patriarca, Andrea, additional, Martinez-Vila, Clara, additional, Cantini, Luca, additional, Zambelli, Alberto, additional, Giusti, Raffaele, additional, Mazzoni, Francesca, additional, Caliman, Enrico, additional, Santoro, Armando, additional, Grosso, Federica, additional, Parisi, Alessandro, additional, Queirolo, Paola, additional, Aujayeb, Avinash, additional, Rimassa, Lorenza, additional, Prat, Aleix, additional, Tucci, Marco, additional, Libertini, Michela, additional, Grisanti, Salvatore, additional, Mukherjee, Uma, additional, Diamantis, Nikolaos, additional, Fusco, Vittorio, additional, Generali, Daniele, additional, Provenzano, Salvatore, additional, Gennari, Alessandra, additional, Tabernero, Josep, additional, Cortellini, Alessio, additional, Evans, Joanne S, additional, Swallow, Judith, additional, Chung, Chris, additional, Patel, Meera, additional, Dettorre, Gino, additional, Ottaviani, Diego, additional, Chowdhury, Amani, additional, Merry, Eve, additional, Chopra, Neha, additional, Lee, Alvin JX, additional, Sng, Christopher CT, additional, Yu, Tamara, additional, Shawe-Taylor, Marianne, additional, Bain, Hamish DC, additional, Wong, Yien Ning Sophia, additional, Galazi, Myria, additional, Benafif, Sarah, additional, Dileo, Palma, additional, Earnshaw, Irina, additional, Patel, Grisma, additional, Wu, Anjui, additional, Soosaipillai, Gehan, additional, Cooper, Lee, additional, Andaleeb, Ramis, additional, Dolly, Saoirse, additional, Srikandarajah, Krishnie, additional, Jones, Eleanor, additional, Van Hemelrijck, Mieke, additional, Moss, Charlotte, additional, Russell, Beth, additional, Chester, John, additional, Loizidou, Angela, additional, Piccart, Martine, additional, Cruz, Claudia A, additional, Reyes, Roxana, additional, Segui, Elia, additional, Marco-Hernández, Javier, additional, Viladot, Margarita, additional, Eremiev, Simeon, additional, Fort-Culillas, Roser, additional, Garcia, Isabel, additional, Liñan, Raquel, additional, Roqué Lloveras, Ariadna, additional, Harbeck, Nadia, additional, Wuerstlein, Rachel, additional, Henze, Franziska, additional, Mahner, Sven, additional, Felip, Eudald, additional, Pous, Anna, additional, D'Avanzo, Francesca, additional, Scotti, Lorenza, additional, Krengli, Marco, additional, Marrari, Andrea, additional, Delfanti, Sara, additional, Maconi, Antonio, additional, Betti, Marta, additional, Tonini, Giuseppe, additional, Di Fazio, Giuseppina Rita, additional, Tondini, Carlo, additional, Chiudinelli, Lorenzo, additional, Franchi, Michela, additional, Bertulli, Rossella, additional, Baggi, Alice, additional, Tovazzi, Valeria, additional, Ficorella, Corrado, additional, Porzio, Giampiero, additional, Saponara, Maristella, additional, Filetti, Marco, additional, Zoratto, Federica, additional, Paoloni, Francesco, additional, Berardi, Rossana, additional, Guida, Annalisa, additional, Bracarda, Sergio, additional, Iglesias, Maria, additional, Sanchez de Torre, Ana, additional, Tagliamento, Marco, additional, Colomba, Emeline, additional, and Pommeret, Fanny, additional

Published
2022
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43. Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

Author

Bergas, Alba, primary, Albasanz-Puig, Adaia, additional, Fernández-Cruz, Ana, additional, Machado, Marina, additional, Novo, Andrés, additional, van Duin, David, additional, Garcia-Vidal, Carolina, additional, Hakki, Morgan, additional, Ruiz-Camps, Isabel, additional, del Pozo, José Luis, additional, Oltolini, Chiara, additional, DeVoe, Catherine, additional, Drgona, Lubos, additional, Gasch, Oriol, additional, Mikulska, Malgorzata, additional, Martín-Dávila, Pilar, additional, Peghin, Maddalena, additional, Vázquez, Lourdes, additional, Laporte-Amargós, Júlia, additional, Durà-Miralles, Xavier, additional, Pallarès, Natàlia, additional, González-Barca, Eva, additional, Álvarez-Uría, Ana, additional, Puerta-Alcalde, Pedro, additional, Aguilar-Company, Juan, additional, Carmona-Torre, Francisco, additional, Clerici, Teresa Daniela, additional, Doernberg, Sarah B., additional, Petrikova, Lucía, additional, Capilla, Silvia, additional, Magnasco, Laura, additional, Fortún, Jesús, additional, Castaldo, Nadia, additional, Carratalà, Jordi, additional, and Gudiol, Carlota, additional

Published
2022
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44. Cytokine response as a biomarker for early diagnosis and outcome prediction of stem cell transplant recipients and acute leukemia patients with invasive aspergillosis

Author

Puerta-Alcalde, Pedro, primary, Ruiz-Camps, Isabel, additional, Gudiol, Carlota, additional, Salavert, Miquel, additional, Barba, Pere, additional, Morandeira, Francisco, additional, Jarque, Isidro, additional, Cuervo, Guillermo, additional, Ayats, Josefina, additional, Carratalà, Jordi, additional, and Garcia-Vidal, Carolina, additional

Published
2022
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45. Clinical assessment of the Omicron outbreak in Europe and trends in morbidity and mortality from COVID-19 and cancer.

Author

Cortellini, Alessio, primary, Aguilar-Company, Juan, additional, Sharkey, Rachel, additional, Sureda Balari, Anna, additional, Bertuzzi, Alexia Francesca, additional, Brunet, Joan, additional, Rizzo, Gianpiero, additional, Perachino, Marta, additional, Lee, Alvin Jun Xing, additional, Chowdhury, Amani, additional, Ruiz-Camps, Isabel, additional, Plaja, Andrea, additional, Hanbury, Georgina Helen, additional, Van Hemelrijck, Mieke, additional, Diamantis, Nikolaos, additional, Gaidano, Gianluca, additional, Grosso, Federica, additional, Gennari, Alessandra, additional, Tabernero, Josep, additional, and Pinato, David J. James, additional

Published
2022
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46. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

Author

Albasanz-Puig, Adaia, Durà-Miralles, Xavier, Laporte-Amargós, Júlia, Mussetti, Alberto, Ruiz-Camps, Isabel, Puerta-Alcalde, Pedro, Abdala, Edson, Oltolini, Chiara, Akova, Murat, Montejo, José Miguel, Mikulska, Malgorzata, Martín-Dávila, Pilar, Herrera, Fabián, Gasch, Oriol, Drgona, Lubos, Morales, Hugo Manuel Paz, Brunel, Anne-Sophie, García, Estefanía, Isler, Burcu, Kern, Winfried V, Retamar-Gentil, Pilar, Aguado, José María, Montero, Milagros, Kanj, Souha S, Sipahi, Oguz R, Calik, Sebnem, Márquez-Gómez, Ignacio, Marin, Jorge I, Gomes, Marisa Z R, Hemmati, Philipp, Araos, Rafael, Peghin, Maddalena, Del Pozo, José Luis, Yáñez, Lucrecia, Tilley, Robert, Manzur, Adriana, Novo, Andres, Pallarès, Natàlia, Bergas, Alba, Carratalà, Jordi, Gudiol, Carlota, On Behalf Of The Ironic Study Group, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), European Society of Clinical Microbiology and Infectious Diseases, and Generalitat de Catalunya

Subjects
Microbiology (medical), Hematologic Malignancies, Resistance, Pseudomonas aeruginosa, bloodstream infection, pneumonia, septic shock, neutropenia, Pneumònia, Antibiòtics, Bacteremia, Guidelines, Monotherapy, Microbiology, Oncología, Infectious-Diseases Society, Antibiotics, Virology, Risk-Factors
Abstract

To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006-2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) vs. 30/242 (12.4%); p < 0.001]. The 30-day case-fatality rate was higher in patients with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%; p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01-2.03]; p = 0.042), whereas the use of appropriate combination empirical treatment was independently associated with improved survival (aHR 0.46 [95%CI 0.27-0.78]; p = 0.004). Appropriate empirical monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76-2.05]; p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile neutropenic patients with suspected pneumonia as the source of infection., Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad, Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain [CB21/13/00009, CB21/13/00079, CB21/13/00054, CB21/13/00086, CB21/13/00012], This work was supported by the Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad, Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC) [CB21/13/00009, CB21/13/00079, CB21/13/00054, CB21/13/00086, CB21/13/00012], Madrid, Spain.

Published
2022
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47. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

Author

Universidad de Sevilla. Departamento de Medicina, Instituto de Salud Carlos III, Ministerio de Economia, Industria y Competitividad (MINECO). España, Albasanz-Puig, Adaia, Durà-Miralles, Xavier, Laporte-Amargós, Júlia, Mussetti, Alberto, Ruiz-Camps, Isabel, Puerta-Alcalde, Pedro, Retamar Gentil, Pilar, Gudiol, Carlota, Universidad de Sevilla. Departamento de Medicina, Instituto de Salud Carlos III, Ministerio de Economia, Industria y Competitividad (MINECO). España, Albasanz-Puig, Adaia, Durà-Miralles, Xavier, Laporte-Amargós, Júlia, Mussetti, Alberto, Ruiz-Camps, Isabel, Puerta-Alcalde, Pedro, Retamar Gentil, Pilar, and Gudiol, Carlota

Abstract

To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA blood stream infection (BSI) (2006–2018). The effect of appropriate empirical combination therapy, appropri ate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) vs. 30/242 (12.4%); p < 0.001]. The 30-day case-fatality rate was higher in patients with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%; p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01–2.03]; p = 0.042), whereas the use of appropriate combination empirical treatment was independently associated with improved survival (aHR 0.46 [95%CI 0.27–0.78]; p = 0.004). Appropriate empiri cal monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76–2.05]; p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile neutropenic patients with suspected pneumonia as the source of infection.

Published
2022

48. The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments:Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021

Author

Tur, Carmen, Dubessy, Anne Laure, Otero-Romero, Susana, Amato, Maria Pia, Derfuss, Tobias, Di Pauli, Franziska, Iacobaeus, Ellen, Mycko, Marcin, Abboud, Hesham, Achiron, Anat, Bellinvia, Angelo, Boyko, Alexey, Casanova, Jean Laurent, Clifford, David, Dobson, Ruth, Farez, Mauricio F., Filippi, Massimo, Fitzgerald, Kathryn C., Fonderico, Mattia, Gouider, Riadh, Hacohen, Yael, Hellwig, Kerstin, Hemmer, Bernhard, Kappos, Ludwig, Ladeira, Filipa, Lebrun-Frénay, Christine, Louapre, Céline, Magyari, Melinda, Mehling, Matthias, Oreja-Guevara, Celia, Pandit, Lekha, Papeix, Caroline, Piehl, Fredrik, Portaccio, Emilio, Ruiz-Camps, Isabel, Selmaj, Krzysztof, Simpson-Yap, Steve, Siva, Aksel, Sorensen, Per Soelberg, Sormani, Maria Pia, Trojano, Maria, Vaknin-Dembinsky, Adi, Vukusic, Sandra, Weinshenker, Brian, Wiendl, Heinz, Winkelmann, Alexander, Zuluaga Rodas, María Isabel, Tintoré, Mar, Stankoff, Bruno, Tur, Carmen, Dubessy, Anne Laure, Otero-Romero, Susana, Amato, Maria Pia, Derfuss, Tobias, Di Pauli, Franziska, Iacobaeus, Ellen, Mycko, Marcin, Abboud, Hesham, Achiron, Anat, Bellinvia, Angelo, Boyko, Alexey, Casanova, Jean Laurent, Clifford, David, Dobson, Ruth, Farez, Mauricio F., Filippi, Massimo, Fitzgerald, Kathryn C., Fonderico, Mattia, Gouider, Riadh, Hacohen, Yael, Hellwig, Kerstin, Hemmer, Bernhard, Kappos, Ludwig, Ladeira, Filipa, Lebrun-Frénay, Christine, Louapre, Céline, Magyari, Melinda, Mehling, Matthias, Oreja-Guevara, Celia, Pandit, Lekha, Papeix, Caroline, Piehl, Fredrik, Portaccio, Emilio, Ruiz-Camps, Isabel, Selmaj, Krzysztof, Simpson-Yap, Steve, Siva, Aksel, Sorensen, Per Soelberg, Sormani, Maria Pia, Trojano, Maria, Vaknin-Dembinsky, Adi, Vukusic, Sandra, Weinshenker, Brian, Wiendl, Heinz, Winkelmann, Alexander, Zuluaga Rodas, María Isabel, Tintoré, Mar, and Stankoff, Bruno

Abstract

Over the recent years, the treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) has evolved very rapidly and a large number of disease-modifying treatments (DMTs) are now available. However, most DMTs are associated with adverse events, the most frequent of which being infections. Consideration of all DMT-associated risks facilitates development of risk mitigation strategies. An international focused workshop with expert-led discussions was sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and was held in April 2021 to review our current knowledge about the risk of infections associated with the use of DMTs for people with MS and NMOSD and corresponding risk mitigation strategies. The workshop addressed DMT-associated infections in specific populations, such as children and pregnant women with MS, or people with MS who have other comorbidities or live in regions with an exceptionally high infection burden. Finally, we reviewed the topic of DMT-associated infectious risks in the context of the current SARS-CoV-2 pandemic. Herein, we summarize available evidence and identify gaps in knowledge which justify further research.

Published
2022

49. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia

Author

Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), European Society of Clinical Microbiology and Infectious Diseases, Generalitat de Catalunya, Albasanz-Puig, Adaia, Durà-Miralles, Xavier, Laporte-Amargós, Júlia, Mussetti, Alberto, Ruiz-Camps, Isabel, Puerta-Alcalde, Pedro, Abdala, Edson, Oltolini, Chiara, Akova, Murat, Montejo, Miguel, Mikulska, Malgorzata, Martín-Dávila, Pilar, Herrera, Fabián, Gasch, Oriol, Drgona, Lubos, Paz Morales, Hugo Manuel, Brunel, Anne-Sophie, García, Estefanía, Isler, Burcu, Kern, Winfried, Retamar Gentil, Pilar, Aguado, José María, Montero, Milagros, Kanj, Souha S., Sipahi, Oguz Resat, Calik, Sebnem, Márquez-Gómez, Ignacio, Marin, Jorge Iván, Gomes, Marisa Z. R., Hemmati, Philipp, Araos, Rafael, Peghin, Maddalena, Pozo, José Luis del, Yáñez, Lucrecia, Tilley, Robert, Manzur, Adriana, Novo, Andres, Pallarès, Natàlia, Bergas, Alba, Carratalà, Jordi, Gudiol, Carlota, Ironic Study Group, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España), European Society of Clinical Microbiology and Infectious Diseases, Generalitat de Catalunya, Albasanz-Puig, Adaia, Durà-Miralles, Xavier, Laporte-Amargós, Júlia, Mussetti, Alberto, Ruiz-Camps, Isabel, Puerta-Alcalde, Pedro, Abdala, Edson, Oltolini, Chiara, Akova, Murat, Montejo, Miguel, Mikulska, Malgorzata, Martín-Dávila, Pilar, Herrera, Fabián, Gasch, Oriol, Drgona, Lubos, Paz Morales, Hugo Manuel, Brunel, Anne-Sophie, García, Estefanía, Isler, Burcu, Kern, Winfried, Retamar Gentil, Pilar, Aguado, José María, Montero, Milagros, Kanj, Souha S., Sipahi, Oguz Resat, Calik, Sebnem, Márquez-Gómez, Ignacio, Marin, Jorge Iván, Gomes, Marisa Z. R., Hemmati, Philipp, Araos, Rafael, Peghin, Maddalena, Pozo, José Luis del, Yáñez, Lucrecia, Tilley, Robert, Manzur, Adriana, Novo, Andres, Pallarès, Natàlia, Bergas, Alba, Carratalà, Jordi, Gudiol, Carlota, and Ironic Study Group

Abstract

To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006−2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) vs. 30/242 (12.4%); p < 0.001]. The 30-day case-fatality rate was higher in patients with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%; p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01−2.03]; p = 0.042), whereas the use of appropriate combination empirical treatment was independently associated with improved survival (aHR 0.46 [95%CI 0.27−0.78]; p = 0.004). Appropriate empirical monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76−2.05]; p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile neutropenic patients with suspected pneumonia as the source of infection.

Published
2022

50. Vaccination Against Sars-Cov-2 Induces Robust Humoral Immune Response in Patients with Previous Hematologic Stem Cell Transplantation

Author

Roldan, Elisa, primary, Del Carmen Jimenez, Moraima, additional, Villacampa, Guillermo, additional, Fernandez-Naval, Candela, additional, Perez, Ana, additional, Fox, Laura, additional, Orti, Guillermo, additional, Salamero, Olga, additional, Barba, Pere, additional, Campins, Magda, additional, Esperalba, Juliana, additional, Ruiz-Camps, Isabel, additional, Crespo, Marta, additional, Hernández-González, Manuel, additional, Bosch, Francesc, additional, Abrisqueta, Pau, additional, and Valcarcel, David, additional

Published
2022
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