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176 results on '"Ruiz-Bermejo, Marta"'

34. Detecting Nonvolatile Life- and Nonlife-Derived Organics in a Carbonaceous Chondrite Analogue with a New Multiplex Immunoassay and Its Relevance for Planetary Exploration

Author

Moreno-Paz, Mercedes, Gómez-Cifuentes, Ana, Ruiz-Bermejo, Marta, Hofstetter, Oliver, Maquieira Catala, Angel, Manchado, Juan M., Morais, Sergi, Sephton, Mark A., Niessner, Reinhard, Knopp, Dietmar, and Parro, Victor

Subjects
Immunoassay, Models, Molecular, Molecular biomarkers, Multiplex inhibitory/competitive immunoassay, Planets, Meteoroids, D- and L- aromatic amino acids, Kerogen type IV, Antibodies, Amino Acids, Aromatic, Planetary exploration, Life detection, Calibration, Exobiology, QUIMICA ANALITICA, Benzo(a)pyrene, D- and L-aromatic amino acids, Organic Chemicals, Volatilization, Research Articles
Abstract

[EN] Potential martian molecular targets include those supplied by meteoritic carbonaceous chondrites such as amino acids and polycyclic aromatic hydrocarbons and true biomarkers stemming from any hypothetical martian biota (organic architectures that can be directly related to once living organisms). Heat extraction and pyrolysis-based methods currently used in planetary exploration are highly aggressive and very often modify the target molecules making their identification a cumbersome task. We have developed and validated a mild, nondestructive, multiplex inhibitory microarray immunoassay and demonstrated its implementation in the SOLID (Signs of Life Detector) instrument for simultaneous detection of several nonvolatile life- and nonlife-derived organic molecules relevant in planetary exploration and environmental monitoring. By utilizing a set of highly specific antibodies that recognize D- or L- aromatic amino acids (Phe, Tyr, Trp), benzo[a]pyrene (B[a]P), pentachlorophenol, and sulfone-containing aromatic compounds, respectively, the assay was validated in the SOLID instrument for the analysis of carbon-rich samples used as analogues of the organic material in carbonaceous chondrites or even Mars samples. Most of the antibodies enabled sensitivities at the 1-10ppb level and some even at the ppt level. The multiplex immunoassay allowed the detection of B[a]P as well as aromatic sulfones in a water/methanol extract of an Early Cretaceous lignite sample (c.a., 140 Ma) representing type IV kerogen. No L- or D-aromatic amino acids were detected, reflecting the advanced diagenetic stage and the fossil nature of the sample. The results demonstrate the ability of the liquid extraction by ultrasonication and the versatility of the multiplex inhibitory immunoassays in the SOLID instrument to discriminate between organic matter derived from life and nonlife processes, an essential step toward life detection outside Earth., This work was supported by granted projects AYA2011-24803, ESP2014-51989-P, and ESP2015-69540-R, from the Ministry of Economy and Competitiveness (MINECO) of Spain, and by Grant No. ST/N000803/1 (United Kingdom). A. G-C was a fellow of Plan de Formación from INTA.

Published
2018

37. Prokaryotic Community Structure and Metabolisms in Shallow Subsurface of Atacama Desert Playas and Alluvial Fans After Heavy Rains: Repairing and Preparing for Next Dry Period

Author

Fernández-Martínez, Miguel Ángel, primary, dos Santos Severino, Rita, additional, Moreno-Paz, Mercedes, additional, Gallardo-Carreño, Ignacio, additional, Blanco, Yolanda, additional, Warren-Rhodes, Kimberley, additional, García-Villadangos, Miriam, additional, Ruiz-Bermejo, Marta, additional, Barberán, Albert, additional, Wettergreen, David, additional, Cabrol, Nathalie, additional, and Parro, Víctor, additional

Published
2019
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38. Environmental parameters, and not phylogeny, determine the composition of extracellular polymeric substances in microbial mats from extreme environments

Author

Blanco, Yolanda, primary, Rivas, Luis Alfonso, additional, González-Toril, Elena, additional, Ruiz-Bermejo, Marta, additional, Moreno-Paz, Mercedes, additional, Parro, Víctor, additional, Palacín, Arantxa, additional, Aguilera, Ángeles, additional, and Puente-Sánchez, Fernando, additional

Published
2019
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39. Detecting Nonvolatile Life- and Nonlife-Derived Organics in a Carbonaceous Chondrite Analogue with a New Multiplex Immunoassay and Its Relevance for Planetary Exploration

Author

Moreno-Paz, Mercedes, primary, Gómez-Cifuentes, Ana, additional, Ruiz-Bermejo, Marta, additional, Hofstetter, Oliver, additional, Maquieira, Ángel, additional, Manchado, Juan M., additional, Morais, Sergi, additional, Sephton, Mark A., additional, Niessner, Reinhard, additional, Knopp, Dietmar, additional, and Parro, Victor, additional

Published
2018
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43. A Comparative Study on HCN Polymers Synthesized by Polymerization of NH4CN or Diaminomaleonitrile in Aqueous Media: New Perspectives for Prebiotic Chemistry and Materials Science.

Author

Ruiz‐Bermejo, Marta, de la Fuente, José L., Carretero‐González, Javier, García‐Fernández, Luis, and Aguilar, M. Rosa

Subjects
*POLYMERS, *MATERIALS science, *CHEMISTRY, *COMPARATIVE studies, *REACTION time
Abstract

HCN polymers are a group of complex and heterogeneous substances that are widely known in the fields of astrobiology and prebiotic chemistry. In addition, they have recently received considerable attention as potential functional material coatings. However, the real nature and pathways of formation of HCN polymers remain open questions. It is well established that the tuning of macromolecular structures determines the properties and practical applications of a polymeric material. Herein, different synthetic conditions were explored for the production of HCN polymers from NH4CN or diaminomaleonitrile in aqueous media with different concentrations of the starting reactants and several reaction times. By using a systematic methodology, both series of polymers were shown to exhibit similar, but not identical, spectroscopic and thermal fingerprints, which resulted in a clear differentiation of their morphological and electrochemical properties. New macrostructures are proposed for HCN polymers, and promising insights are discussed for prebiotic chemistry and materials science on the basis of the experimental results. [ABSTRACT FROM AUTHOR]

Published
2019
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48. Method for crystallisation from a solution

Author

Osuna-Esteban, Susana, Zorzano, María Paz, Menor-Salván, César, Ruiz Bermejo, Marta, and Veintemillas-Verdaguer, S.

Abstract

The present invention relates to a novel method and to a device for obtaining crystals from a substance, comprising: (i) preparing a saturated dissolution of the substance to be crystallized in a suitable solvent in a reaction vessel; (ii) generating an aerosol in the reaction vessel; (iii) crystallizing the substance; and (iv) recovering the crystals at the bottom of the reaction vessel. The method is especially suitable for crystallizing substances which are typically difficult to crystallize and can lead to a chiral amplification result., La presente invención relaciona a un nuevo método y a un dispositivo para obtener los cristales de una sustancia, comprendiendo: (i) preparando una disolución saturada de la sustancia que se cristalizará en un disolvente adecuado en un recipiente de reacción (ii) generar un aerosol en el recipiente de reacción (iii) cristalizar la sustancia y (iv) recuperando los cristales en el fondo del recipiente de reacción. El método es especialmente adecuado para cristalizar las sustancias que el son típicamente difícil cristalizar y el bote conducen a un resultado de la amplificación del quiral., Consejo Superior de Investigaciones Científicas (España), A1 Solicitud de patentes con informe sobre el estado de la técnica

Published
2008

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