1. Anti-retinal Antibodies in Sarcoidosis.
- Author
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Avendaño-Monje, Carmen L., Cordero-Coma, Miguel, Mauriz, José L., Calleja-Antolín, Sara, Fonollosa, Alex, Garrote Llordén, Ana, Martin García-Sancho, Juan, Sánchez-Salazar, María I., and Ruiz de Morales, José G.
- Subjects
CARBONIC anhydrase ,IMMUNOGLOBULINS ,SARCOIDOSIS ,UVEITIS ,AUTOANTIBODIES - Abstract
To measure, characterize, and evaluate the clinical significance of anti-retinal antibodies in patients with sarcoid uveitis. Prospective study of anti-retinal antibodies in 45 patients with biopsy-proven sarcoidosis (25 with and 20 without uveitis). Results were compared with patients with confirmed infectious uveitis (n = 40) and non-infectious uveitis (n = 40). Among sarcoidosis patients, anti-retinal antibodies were positive in 23/25 patients with uveitis and in 15/20 without uveitis [P = ns]. The most common antigens recognized were carbonic anhydrase II (14/23) and α-enolase (6/23). Anti-carbonic anhydrase II autoantibodies were infrequently detected in sarcoidosis patients without uveitis (2 out 15, P <.001), in patients with infectious uveitis (1 out 18, P <.001), and in patients with non-infectious uveitis (8 out 37, P <.001). Anti-retinal antibodies recognizing carbonic anhydrase II are common in sarcoid uveitis. Although not fully sensitive and specific, they might be a useful non-invasive diagnostic tool for the diagnosis of sarcoid uveitis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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