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1. Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008–2017)

Author

Sánchez, Fernando Fernández, Noureddine, Mariam, Rosas, Gabriel, Lima, Javier de la Torre, Blanco, Roberto, Boado, María Victoria, Lázaro, Marta Campaña, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, López, Ma Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Goenaga, Miguel Ángel, Idígoras, Pedro, Iribarren, José Antonio, Yarza, Alberto Izaguirre, Urkola, Xabier Kortajarena, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Rey, Enrique Miguez, Mayo, María Rodríguez, Sánchez, Efrén, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, Ma, Castro, Beatriz, Rosado, Dácil García, del Carmen Durán, Ma, Gómez, Ma Antonia Miguel, Lacalzada, Juan, Nassar, Ibrahim, Ciezar, Antonio Plata, Iglesias, José Ma Reguera, Álvarez, Víctor Asensi, Costas, Carlos, Hera, Jesús de la, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, García-Pares, Delia, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Caballero, Gregorio Cuerpo, Montero, Antonia Delgado, Mansilla, Ana García, Leoni, Ma Eugenia García, Ramallo, Víctor González, Hernández, Martha Kestler, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Muñoz, Patricia, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, Antorrena, Isabel, Loeches, Belén, Quirós, Alejandro Martín, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Saldaña, Araceli, Balbín, Jesús Agüero, Castillo, Carlos Armiñanzas, Arnaiz, Ana, de las Revillas, Francisco Arnaiz, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Izquierdo, Rubén Gómez, García, Iván, Rico, Claudia González, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Calderón Parra, Jorge, Cobo, Marta, Domínguez, Fernando, Fortaleza, Alberto, Pavía, Pablo García, González, Jesús, Cruz, Ana Fernández, Múñez, Elena, Ramos, Antonio, Romero, Isabel Sánchez, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, Río, Alejandro del, Rodríguez-Roda Stuart, Jorge, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, Villegas, Antonio Cabrera, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Blasco, Andrés Canut, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, Uriarte, Oscar García, López, Alejandro Martín, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, Gloria, García-Domínguez, Antonio, Sánchez-Porto, Leal, José Ma Arribas, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, Valenzuela, Gonzalo de la Morena, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Rodríguez, Anai Moreno, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, Ma Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Yañez, Ivan Keituqwa, Martínez, Julián Navarro, Ballesta, Ana Peláez, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Seco, Ma Cruz Pérez, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Ruiz, Ma Pilar Palacián, Porres, Juan Carlos, Vidal, Begoña Alcaraz, Trigueros, Nazaret Cobos, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Sánchez, Roberto Jiménez, Almazán, Amaya Jimeno, Freire, Alejandro Ortín, González, Monserrat Viqueira, Ramis, Pere Pericás, Blanco, Ma Ángels Ribas, Ruiz de Gopegui Bordes, Enrique, Bonet, Laura Vidal, Munera, Ma Carmen Bellón, Garaizabal, Elena Escribano, Martínez, Antonia Tercero, Segura Luque, Juan Carlos, Badía, Cristina, Palop, Lucía Boix, Xercavins, Mariona, Eloy Gómez Nebreda, Sónia Ibars., Herrera, Ibalia Horcajada, Gallego Héctor Marrero Santiago, Irene Menduiña, de Miguel Martínez, Isabel, Álamo, Elena Pisos, Pericàs, Juan M., Kestler, Martha, Mari-Hualde, Amaia, Goenaga, Miguel Á., Fariñas, M. Carmen, Rodríguez-Álvarez, Regino, Ojeda-Burgos, Guillermo, Gálvez-Acebal, Juan, and Hidalgo-Tenorio, Carmen

Published
2021
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2. Role of age and comorbidities in mortality of patients with infective endocarditis

Author

Armiñanzas, Carlos, Fariñas-Alvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez Sellés, Manuel, Miró Meda, José Mª., Pericás, Juan Manuel, Goenaga, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez Álvarez, Regino, Castelo Corral, Laura, Gálvez-Acebal, Juan, Martínez Marcos, Francisco Javier, Fariñas, Maria Carmen, Fernández Sánchez, Fernando, Noureddine, Mariam, Rosas, Gabriel, de la Torre Lima, Javier, Aramendi, José, Bereciartua, Elena, Blanco, María José, Blanco, Roberto, Boado, María Victoria, Campaña Lázaro, Marta, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Irurzun Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García López, Mª. Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez Bailón, Isabel, Ruiz Morales, Josefa, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Idígoras, Pedro, Iribarren, José Antonio, Izaguirre Yarza, Alberto, Kortajarena Urkola, Xabier, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez Rey, Enrique, Rodríguez Mayo, María, Sánchez, Efrén, Sousa Regueiro, Dolores, Martínez, Francisco Javier, Alonso, Mª. del Mar, Castro, Beatriz, García Rosado, Dácil, Durán, Mª. del Carmen, Miguel Gómez, Mª. Antonia, Lacalzada, Juan, Nassar, Ibrahim, Plata Ciezar, Antonio, Reguera Iglesias, José Mª., Asensi Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández Suárez, Jonnathan, Iglesias Fraile, Lisardo, León Arguero, Víctor, López Menéndez, José, Mencia Bajo, Pilar, Morales, Carlos, Moreno Torrico, Alfonso, Palomo, Carmen, Paya Martínez, Begoña, Rodríguez Esteban, Ángeles, Rodríguez García, Raquel, Telenti Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Cuerpo Caballero, Gregorio, Delgado Montero, Antonia, Fernández Cruz, Ana, García Mansilla, Ana, García Leoni, Mª. Eugenia, Kestler Hernández, Martha, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Menárguez, Mª. Cruz, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Verde Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Martín Quirós, Alejandro, Moreno, Mar, Ramírez, Ulises, Rial Bastón, Verónica, Romero, María, Saldaña, Araceli, Agüero Balbín, Jesús, Amado, Cristina, Armiñanzas Castillo, Carlos, Arnaiz García, Ana, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Gómez Izquierdo, Rubén, García, Iván, González-Rico, Claudia, Gutiérrez-Cuadra, Manuel, Gutiérrez Díez, José, Pajarón, Marcos, Parra, José Antonio, Sarralde, Aurelio, Teira, Ramón, Domínguez, Fernando, García Pavía, Pablo, González, Jesús, Orden, Beatriz, Ramos, Antonio, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Ruiz, Soledad, Hidalgo Tenorio, Carmen, Almendro Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo Jambrina, Román, de Cueto, Marina, Gálvez Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Canut Blasco, Andrés, Cordo Mollar, José, Gainzarain Arana, Juan Carlos, García Uriarte, Oscar, Martín López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, García Domínguez, Gloria, Sánchez-Porto, Antonio, Arribas Leal, José Mª., García Vázquez, Elisa, Hernández Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero Gálvez, Eva, Maicas Bellido, Carolina, Largo Pau, José, Sepúlveda, Mª. Antonia, Toledano Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales Alcolea, Eva, Egea Serrano, Pilar, Hernández Roca, José Joaquín, Keituqwa Yañez, Ivan, Peláez Ballesta, Ana, Soriano, Víctor, Moreno Escobar, Eduardo, Peña Monje, Alejandro, Sánchez Cabrera, Valme, Vinuesa García, David, Arrizabalaga Asenjo, María, Cifuentes Luna, Carmen, Núñez Morcillo, Juana, Pérez Seco, Mª. Cruz, Villoslada Gelabert, Aroa, Aured Guallar, Carmen, Fernández Abad, Nuria, García Mangas, Pilar, Matamala Adell, Marta, Palacián Ruiz, Mª. Pilar, Porres, Juan Carlos, Alcaraz Vidal, Begoña, Cobos Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Jiménez Sánchez, Roberto, Jimeno Almazán, Amaya, Ortín Freire, Alejandro, Viqueira González, Monserrat, Pericás Ramis, Pere, Ribas Blanco, Mª. Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal Bonet, Laura, Bellón Munera, Mª. Carmen, Escribano Garaizabal, Elena, Tercero Martínez, Antonia, and Segura Luque, Juan Carlos

Published
2019
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4. An increase in erythromycin resistance in methicillin-susceptible Staphylococcus aureus from blood correlates with the use of macrolide/lincosamide/streptogramin antibiotics. EARS-Net Spain (2004–2020)

Author

El Mammery, Achraf, primary, Ramírez de Arellano, Eva, additional, Cañada-García, Javier E., additional, Cercenado, Emilia, additional, Villar-Gómara, Laura, additional, Casquero-García, Verónica, additional, García-Cobos, Silvia, additional, Lepe, José Antonio, additional, Ruiz de Gopegui Bordes, Enrique, additional, Calvo-Montes, Jorge, additional, Larrosa Escartín, Nieves, additional, Cantón, Rafael, additional, Pérez-Vázquez, María, additional, Aracil, Belén, additional, and Oteo-Iglesias, Jesús, additional

Published
2023
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6. Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study

Author

Yahav, Dafna [0000-0003-3181-9791], Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Rubén, Rivera, Alba, Pulcini, Céline, Fattah, Manal Abdel, Haquin, Justine, Macgowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ami, Ronen Ben, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, Cueto, Marina de, Oliver, Antonio, Ruiz de Gopegui Bordes, Enrique, Cano, Ángela, Machuca, Isabel, Gozalo-Margüello, Mónica, Martínez-Martínez, Luis, González-Barbera, Eva M., Gómez Alfaro, Iris, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller-Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, Yahav, Dafna, Yahav, Dafna [0000-0003-3181-9791], Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Rubén, Rivera, Alba, Pulcini, Céline, Fattah, Manal Abdel, Haquin, Justine, Macgowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ami, Ronen Ben, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, Cueto, Marina de, Oliver, Antonio, Ruiz de Gopegui Bordes, Enrique, Cano, Ángela, Machuca, Isabel, Gozalo-Margüello, Mónica, Martínez-Martínez, Luis, González-Barbera, Eva M., Gómez Alfaro, Iris, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller-Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, and Yahav, Dafna

Abstract

[Introduction] There is no consensus regarding optimal duration of antibiotic therapy for Pseudomonas aeruginosa bacteremia. We aimed to evaluate the impact of short antibiotic course., [Methods] We present a retrospective multicenter study including patients with P. aeruginosa bacteremia during 2009–2015. We evaluated outcomes of patients treated with short (6–10 days) versus long (11–15 days) antibiotic courses. The primary outcome was a composite of 30-day mortality or bacteremia recurrence and/or persistence. Univariate and inverse probability treatment-weighted (IPTW) adjusted multivariate analysis for the primary outcome was performed. To avoid immortal time bias, the landmark method was used., [Results] We included 657 patients; 273 received a short antibiotic course and 384 a long course. There was no significant difference in baseline characteristics of patients. The composite primary outcome occurred in 61/384 patients in the long-treatment group (16%) versus 32/273 in the short-treatment group (12%) (p = 0.131). Mortality accounted for 41/384 (11%) versus 25/273 (9%) of cases, respectively. Length of hospital stay was significantly shorter in the short group [median 13 days, interquartile range (IQR) 9–21 days, versus median 15 days, IQR 11–26 days, p = 0.002]. Ten patients in the long group discontinued antibiotic therapy owing to adverse events, compared with none in the short group. On univariate and multivariate analyses, duration of therapy was not associated with the primary outcome., [Conclusions] In this retrospective study, 6–10 days of antibiotic course for P. aeruginosa bacteremia were as effective as longer courses in terms of survival and recurrence. Shorter therapy was associated with reduced length of stay and less drug discontinuation.

Published
2022

8. Mural Endocarditis: The GAMES Registry Series and Review of the Literature

Author

Gutiérrez-Villanueva, Andrea, Muñoz, Patricia, Delgado-Montero, Antonia, Olmedo-Samperio, María, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Zarauza, Jesús, García i Pares, Delia, Goenaga, Miguel Ángel, Ojeda-Burgos, Guillermo, Goikoetxea-Agirre, Ane Josune, Reguera-Iglesias, José Mª, Ramos, Antonio, Fernández-Cruz, Ana, Fernández-Sánchez, Fernando, García de Lomas, José Mª, Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Blanco-Vidal, María José, Blanco, Roberto, Boado, María Victoria, Campaña-Lázaro, Marta, Crespo, Alejandro, Guio-Carrión, Laura, del Álamo Martínez-Lagos, Mikel, Euba-Ugarte, Gorane, Goikoetxea, Ane Josune, Ibarrola-Hierro, Marta, Iruretagoyena, José Ramón, Irurzun-Zuazabal, Josu, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García-López, Mª Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Rodríguez-Bailón, Isabel, Ruiz-Morales, Josefa, Azkune-Galparsoro, Harkaitz, Berritu-Boronat, Elisa, Bustinduy-Odriozola, Mª Jesús, del Bosque Martín, Cristina, Echeverría, Tomás, Eizaguirre-Yarza, Alberto, Fuentes, Ana, Goyeneche del Río, Muskilda, Granda-Bauza, Ángela, Iribarren, José Antonio, Kortajarena-Urkola, Xabier, Pérez-Moreiras López, José Ignacio, Rengel-Jiménez, Ainhoa, Reviejo, Karlos, Sáez-Berbejillo, Alberto, Sánchez-Haza, Elou, Sebastián-Alda, Rosa, Solla-Ruiz, Itziar, Unamuno-Ugartemendia, Irati, Anza, Diego Vicente, Villanueva-Benito, Iñaki, Zabalo-Arrieta, Mar, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Miguez-Rey, Enrique, Rodríguez-Mayo, María, Sánchez, Efrén, Sousa-Regueiro, Dolores, Martínez, Francisco Javier, del Mar Alonso, null, Castro, Beatriz, Delgado-Melian, Teresa, Fernández-Sarabia, Javier, García-Rosado, Dácil, González-González, Julia, Lacalzada, Juan, Lorenzo de la Peña, Lissete, Pérez-Ramírez, Alina, Prada-Arrondo, Pablo, Rodríguez-Moreno, Fermín, Plata-Ciezar, Antonio, Asensi-Álvarez, Víctor, Costas, Carlos, de la Hera, Jesús, Fernández-Suárez, Jonnathan, Iglesias-Fraile, Lisardo, León-Arguero, Víctor, López-Menéndez, José, Mencia-Bajo, Pilar, Morales, Carlos, Moreno-Torrico, Alfonso, Palomo, Carmen, Paya-Martínez, Begoña, Rodríguez-Esteban, Ángeles, Rodríguez-García, Raquel, Telenti-Asensio, Mauricio, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, Hernández-Meneses, Marta, Llopis-Pérez, Jaume, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Cuerpo-Caballero, Gregorio, González-Mansilla, Ana, García-Leoni, Mª Eugenia, Gargallo, Esther, González-Ramallo, Víctor, Kestler-Hernández, Martha, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Verde-Moreno, Eduardo, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Rial-Bastón, Verónica, Romero, María, Rosillo, Sandra, Agüero-Balbín, Jesús, Amado, Cristina, Armiñanzas-Castillo, Carlos, Arnaiz, Ana, Arnaiz de las Revillas, Francisco, Cobo Belaustegui, Manuel, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Fernández-Sampedro, Marta, García, Iván, González-Rico, Claudia, Gutierrez-Fernandez, Laura, Gutiérrez-Cuadra, Manuel, Gutiérrez-Díez, José, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Calderón-Parra, Jorge, Cobo, Marta, Domínguez, Fernando, García-Pavía, Pablo, Ramos-Martínez, Antonio, Sánchez-Romero, Isabel, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Rodríguez-Roda Stuart, Jorge, Ruiz, Soledad, Hidalgo-Tenorio, Carmen, Almendro-Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo-Jambrina, Román, de Cueto, Marina, Gálvez-Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Azcona-Gutiérrez, José Manuel, Blanco, José Ramón, Cabrera-Villegas, Antonio, García-Álvarez, Lara, García-García, Concepción, Oteo, José Antonio, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, null, Fernández, null, Martínez, Amparo, Prieto, null, Regueiro, Benito, Tijeira, null, Vega, Marino, Canut-Blasco, Andrés, Mollar, José Cordo, Gainzarain-Arana, Juan Carlos, García-Uriarte, Oscar, Martín-López, Alejandro, Ortiz de Zárate, Zuriñe, Urturi-Matos, José Antonio, Sánchez-Porto, Antonio, Úbeda-Iglesias, Alejandro, Arribas-Leal, José Mª, García-Vázquez, Elisa, Hernández-Torres, Alicia, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Moreno-Rodríguez, Anai, Tarabini-Castellani, Paola, Heredero-Gálvez, Eva, Maicas-Bellido, Carolina, Largo-Pau, José, Sepúlveda, Mª Antonia, Toledano-Sierra, Pilar, Iqbal-Mirza, Sadaf Zafar, Cascales-Alcolea, Eva, Keituqwa-Yañez, Ivan, Navarro-Martínez, Julián, Peláez-Ballesta, Ana, Moreno-Escobar, Eduardo, Peña-Monje, Alejandro, Sánchez-Cabrera, Valme, Vinuesa-García, David, Arrizabalaga-Asenjo, María, Cifuentes-Luna, Carmen, Núñez-Morcillo, Juana, Pérez-Seco, Mª Cruz, Villoslada-Gelabert, Aroa, Aured-Guallar, Carmen, Fernández-Abad, Nuria, García-Mangas, Pilar, Matamala-Adell, Marta, Palacián-Ruiz, Mª Pilar, Porres, Juan Carlos, Alcaraz-Vidal, Begoña, Cobos-Trigueros, Nazaret, Del Amor Espín, María Jesús, Giner-Caro, José Antonio, Jiménez-Sánchez, Roberto, Jimeno-Almazán, Amaya, Ortín-Freire, Alejandro, Viqueira-González, Monserrat, Pericás-Ramis, Pere, Ribas-Blanco, Mª Ángels, Ruiz de Gopegui Bordes, Enrique, Vidal-Bonet, Laura, Bellón-Munera, Mª Carmen, Escribano-Garaizabal, Elena, Tercero-Martínez, Antonia, Segura-Luque, Juan Carlos, Badía, Cristina, Boix-Palop, Lucía, Xercavins, Mariona, Ibars, Sónia, Bosch, Xerach, Gómez-Nebreda, Eloy, Horcajada-Herrera, Ibalia, Menduiña-Gallego, Irene, Pulido, Imanol, Marrero-Santiago, Héctor, de Miguel Martínez, Isabel, Pisos-Álamo, Elena, Aguilar-Blanco, Eva Mª, Catalán-González, Mercedes, Corres-Peiretti, María Angélica, Eixerés-Esteve, Andrea, Domínguez-Pérez, Laura, de Cossío Tejido, Santiago, Galván-Román, Francisco, García-Robles, José Antonio, López-Medrano, Francisco, López-Gude, Mª Jesús, Orellana-Miguel, Mª Ángeles, Pilkington, Patrick, Revilla-Ostalaza, Yolanda, Morales, Juan Ruiz, Ruiz-Solís, Sebastián, Collado, Ana Sabín, Sánchez-Fernández, Marcos, Rallo, Javier Solera, Martín, Jorge Solís, Cuervo, Guillermo, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Inmaculada, Grillo, Sara, Ardanuy, Carmen, Berbel, Dámaris, Sánchez-Salado, José Carlos, Alegre, Oriol, Ruiz-Majoral, Alejandro, Sbraga, Fabrizio, Blasco, Arnau, Sánchez, Laura Gracia, Sánchez-Rodríguez, Iván, Álvarez, Beatriz, Cabello-Úbeda, Alfonso, Fernández-Roblas, Ricardo, Navas-Lobato, Miguel Ángel, Pello, Ana María, de la Peña Triguero, Mireia, Figueroa-Cerón, Ruth Esther, Ruiz-Gómez, Lara, Ble, Mireia, Horcajada-Gallego, Juan Pablo, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, 0000-0003-1189-1120, and Universidad de Cantabria

Subjects
Microbiology (medical), medicine.medical_specialty, medicine.medical_treatment, Charlson index, Infections, Hospital patients, Mural, Internal medicine, medicine, Endocarditis, Malalts hospitalitzats, business.industry, Brief Report, medicine.disease, Infeccions, Transplantation, Catheter, Non-valvular endocarditis, Infectious Diseases, Infective endocarditis, Etiology, Hemodialysis, Complication, business, human activities
Abstract

Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES)., [Introduction] Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis., [Methods] Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series., [Results] Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p, [Conclusion] MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.

Published
2021

9. Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008–2017)

Author

Pericàs, Juan M., primary, Ambrosioni, Juan, additional, Muñoz, Patricia, additional, de Alarcón, Arístides, additional, Kestler, Martha, additional, Mari-Hualde, Amaia, additional, Moreno, Asunción, additional, Goenaga, Miguel Á., additional, Fariñas, M. Carmen, additional, Rodríguez-Álvarez, Regino, additional, Ojeda-Burgos, Guillermo, additional, Gálvez-Acebal, Juan, additional, Hidalgo-Tenorio, Carmen, additional, Noureddine, Mariam, additional, Miró, José M., additional, Sánchez, Fernando Fernández, additional, Rosas, Gabriel, additional, Lima, Javier de la Torre, additional, Blanco, Roberto, additional, Boado, María Victoria, additional, Lázaro, Marta Campaña, additional, Crespo, Alejandro, additional, Goikoetxea, Josune, additional, Iruretagoyena, José Ramón, additional, Zuazabal, Josu Irurzun, additional, López-Soria, Leire, additional, Montejo, Miguel, additional, Nieto, Javier, additional, Rodrigo, David, additional, Rodríguez, Regino, additional, Vitoria, Yolanda, additional, Voces, Roberto, additional, López, Ma Victoria García, additional, Georgieva, Radka Ivanova, additional, Ojeda, Guillermo, additional, Bailón, Isabel Rodríguez, additional, Morales, Josefa Ruiz, additional, Cuende, Ana María, additional, Echeverría, Tomás, additional, Fuerte, Ana, additional, Gaminde, Eduardo, additional, Goenaga, Miguel Ángel, additional, Idígoras, Pedro, additional, Iribarren, José Antonio, additional, Yarza, Alberto Izaguirre, additional, Urkola, Xabier Kortajarena, additional, Reviejo, Carlos, additional, Carrasco, Rafael, additional, Climent, Vicente, additional, Llamas, Patricio, additional, Merino, Esperanza, additional, Plazas, Joaquín, additional, Reus, Sergio, additional, Álvarez, Nemesio, additional, Bravo-Ferrer, José María, additional, Castelo, Laura, additional, Cuenca, José, additional, Llinares, Pedro, additional, Rey, Enrique Miguez, additional, Mayo, María Rodríguez, additional, Sánchez, Efrén, additional, Regueiro, Dolores Sousa, additional, Martínez, Francisco Javier, additional, del Mar Alonso, Ma, additional, Castro, Beatriz, additional, Rosado, Dácil García, additional, del Carmen Durán, Ma, additional, Gómez, Ma Antonia Miguel, additional, Lacalzada, Juan, additional, Nassar, Ibrahim, additional, Ciezar, Antonio Plata, additional, Iglesias, José Ma Reguera, additional, Álvarez, Víctor Asensi, additional, Costas, Carlos, additional, Hera, Jesús de la, additional, Suárez, Jonnathan Fernández, additional, Fraile, Lisardo Iglesias, additional, Arguero, Víctor León, additional, Menéndez, José López, additional, Bajo, Pilar Mencia, additional, Morales, Carlos, additional, Torrico, Alfonso Moreno, additional, Palomo, Carmen, additional, Martínez, Begoña Paya, additional, Esteban, Ángeles Rodríguez, additional, García, Raquel Rodríguez, additional, Asensio, Mauricio Telenti, additional, Almela, Manuel, additional, Azqueta, Manuel, additional, Brunet, Mercè, additional, Bodro, Marta, additional, Cartañá, Ramón, additional, Falces, Carlos, additional, Fita, Guillermina, additional, Fuster, David, additional, García de la Mària, Cristina, additional, García-Pares, Delia, additional, Hernández-Meneses, Marta, additional, Pérez, Jaume Llopis, additional, Marco, Francesc, additional, Nicolás, David, additional, Ninot, Salvador, additional, Quintana, Eduardo, additional, Paré, Carlos, additional, Pereda, Daniel, additional, Pericás, Juan M., additional, Pomar, José L., additional, Ramírez, José, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Soy, Dolors, additional, Téllez, Adrián, additional, Tolosana, José M., additional, Vidal, Bárbara, additional, Vila, Jordi, additional, Adán, Iván, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Celemín, Daniel, additional, Caballero, Gregorio Cuerpo, additional, Montero, Antonia Delgado, additional, Mansilla, Ana García, additional, Leoni, Ma Eugenia García, additional, Ramallo, Víctor González, additional, Hernández, Martha Kestler, additional, Hualde, Amaia Mari, additional, Marín, Mercedes, additional, Martínez-Sellés, Manuel, additional, Rincón, Cristina, additional, Rodríguez-Abella, Hugo, additional, Rodríguez-Créixems, Marta, additional, Pinilla, Blanca, additional, Pinto, Ángel, additional, Valerio, Maricela, additional, Vázquez, Pilar, additional, Moreno, Eduardo Verde, additional, Antorrena, Isabel, additional, Loeches, Belén, additional, Quirós, Alejandro Martín, additional, Moreno, Mar, additional, Ramírez, Ulises, additional, Bastón, Verónica Rial, additional, Romero, María, additional, Saldaña, Araceli, additional, Balbín, Jesús Agüero, additional, Castillo, Carlos Armiñanzas, additional, Arnaiz, Ana, additional, de las Revillas, Francisco Arnaiz, additional, Belaustegui, Manuel Cobo, additional, Fariñas, María Carmen, additional, Fariñas-Álvarez, Concepción, additional, Izquierdo, Rubén Gómez, additional, García, Iván, additional, Rico, Claudia González, additional, Gutiérrez-Cuadra, Manuel, additional, Díez, José Gutiérrez, additional, Pajarón, Marcos, additional, Parra, José Antonio, additional, Teira, Ramón, additional, Zarauza, Jesús, additional, Calderón Parra, Jorge, additional, Cobo, Marta, additional, Domínguez, Fernando, additional, Fortaleza, Alberto, additional, Pavía, Pablo García, additional, González, Jesús, additional, Cruz, Ana Fernández, additional, Múñez, Elena, additional, Ramos, Antonio, additional, Romero, Isabel Sánchez, additional, Centella, Tomasa, additional, Hermida, José Manuel, additional, Moya, José Luis, additional, Martín-Dávila, Pilar, additional, Navas, Enrique, additional, Oliva, Enrique, additional, Río, Alejandro del, additional, Rodríguez-Roda Stuart, Jorge, additional, Ruiz, Soledad, additional, Tenorio, Carmen Hidalgo, additional, Delia, Manuel Almendro, additional, Araji, Omar, additional, Barquero, José Miguel, additional, Jambrina, Román Calvo, additional, de Cueto, Marina, additional, Acebal, Juan Gálvez, additional, Méndez, Irene, additional, Morales, Isabel, additional, López-Cortés, Luis Eduardo, additional, García, Emilio, additional, Haro, Juan Luis, additional, Lepe, José Antonio, additional, López, Francisco, additional, Luque, Rafael, additional, Alonso, Luis Javier, additional, Azcárate, Pedro, additional, Azcona Gutiérrez, José Manuel, additional, Blanco, José Ramón, additional, Villegas, Antonio Cabrera, additional, García-Álvarez, Lara, additional, Oteo, José Antonio, additional, Sanz, Mercedes, additional, de Benito, Natividad, additional, Gurguí, Mercé, additional, Pacho, Cristina, additional, Pericas, Roser, additional, Pons, Guillem, additional, Álvarez, M., additional, Fernández, A.L., additional, Martínez, Amparo, additional, Prieto, A., additional, Regueiro, Benito, additional, Tijeira, E., additional, Vega, Marino, additional, Blasco, Andrés Canut, additional, Mollar, José Cordo, additional, Gainzarain Arana, Juan Carlos, additional, Uriarte, Oscar García, additional, López, Alejandro Martín, additional, Ortiz de Zárate, Zuriñe, additional, Urturi Matos, José Antonio, additional, Gloria, García-Domínguez, additional, Antonio, Sánchez-Porto, additional, Leal, José Ma Arribas, additional, Vázquez, Elisa García, additional, Torres, Alicia Hernández, additional, Blázquez, Ana, additional, Valenzuela, Gonzalo de la Morena, additional, Alonso, Ángel, additional, Aramburu, Javier, additional, Calvo, Felicitas Elena, additional, Rodríguez, Anai Moreno, additional, Tarabini-Castellani, Paola, additional, Gálvez, Eva Heredero, additional, Bellido, Carolina Maicas, additional, Pau, José Largo, additional, Sepúlveda, Ma Antonia, additional, Sierra, Pilar Toledano, additional, Iqbal-Mirza, Sadaf Zafar, additional, Alcolea, Eva Cascales, additional, Yañez, Ivan Keituqwa, additional, Martínez, Julián Navarro, additional, Ballesta, Ana Peláez, additional, Escobar, Eduardo Moreno, additional, Monje, Alejandro Peña, additional, Cabrera, Valme Sánchez, additional, García, David Vinuesa, additional, Asenjo, María Arrizabalaga, additional, Luna, Carmen Cifuentes, additional, Morcillo, Juana Núñez, additional, Seco, Ma Cruz Pérez, additional, Gelabert, Aroa Villoslada, additional, Guallar, Carmen Aured, additional, Abad, Nuria Fernández, additional, Mangas, Pilar García, additional, Adell, Marta Matamala, additional, Ruiz, Ma Pilar Palacián, additional, Porres, Juan Carlos, additional, Vidal, Begoña Alcaraz, additional, Trigueros, Nazaret Cobos, additional, Del Amor Espín, María Jesús, additional, Giner Caro, José Antonio, additional, Sánchez, Roberto Jiménez, additional, Almazán, Amaya Jimeno, additional, Freire, Alejandro Ortín, additional, González, Monserrat Viqueira, additional, Ramis, Pere Pericás, additional, Blanco, Ma Ángels Ribas, additional, Ruiz de Gopegui Bordes, Enrique, additional, Bonet, Laura Vidal, additional, Munera, Ma Carmen Bellón, additional, Garaizabal, Elena Escribano, additional, Martínez, Antonia Tercero, additional, Segura Luque, Juan Carlos, additional, Badía, Cristina, additional, Palop, Lucía Boix, additional, Xercavins, Mariona, additional, Eloy Gómez Nebreda, Sónia Ibars., additional, Herrera, Ibalia Horcajada, additional, Gallego Héctor Marrero Santiago, Irene Menduiña, additional, de Miguel Martínez, Isabel, additional, and Álamo, Elena Pisos, additional

Published
2021
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10. Risk factors for mortality among patients with Pseudomonas aeruginosa bacteraemia: a retrospective multicentre study

Author

Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Rubén, Rivera, Alba, Pulcini, Céline, Abdel Fattah, Manal, Haquin, Justine, Macgowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ben Ami, Ronen, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, Morales, Isabel, Oliver, Antonio, Ruiz de Gopegui Bordes, Enrique, Cano, Ángela, Machuca, Isabel, Gozalo-Margüello, Mónica, Martínez-Martínez, Luis, González-Barbera, Eva M., Gómez Alfaro, Iris, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller-Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, Yahav, Dafna, Babich, Tanya, Naucler, Pontus, Valik, John Karlsson, Giske, Christian G., Benito, Natividad, Cardona, Rubén, Rivera, Alba, Pulcini, Céline, Abdel Fattah, Manal, Haquin, Justine, Macgowan, Alasdair, Grier, Sally, Chazan, Bibiana, Yanovskay, Anna, Ben Ami, Ronen, Landes, Michal, Nesher, Lior, Zaidman-Shimshovitz, Adi, McCarthy, Kate, Paterson, David L., Tacconelli, Evelina, Buhl, Michael, Mauer, Susanna, Rodríguez-Baño, Jesús, Morales, Isabel, Oliver, Antonio, Ruiz de Gopegui Bordes, Enrique, Cano, Ángela, Machuca, Isabel, Gozalo-Margüello, Mónica, Martínez-Martínez, Luis, González-Barbera, Eva M., Gómez Alfaro, Iris, Salavert, Miguel, Beovic, Bojana, Saje, Andreja, Mueller-Premru, Manica, Pagani, Leonardo, Vitrat, Virginie, Kofteridis, Diamantis, Zacharioudaki, Maria, Maraki, Sofia, Weissman, Yulia, Paul, Mical, Dickstein, Yaakov, Leibovici, Leonard, and Yahav, Dafna

Abstract

This study aimed to evaluate risk factors for 30-day mortality among hospitalised patients with Pseudomonas aeruginosa bacteraemia, a highly fatal condition. A retrospective study was conducted between 1 January 2009 and 31 October 2015 in 25 centres (9 countries) including 2396 patients. Univariable and multivariable analyses of risk factors were conducted for the entire cohort and for patients surviving ≥48 h. A propensity score for predictors of appropriate empirical therapy was introduced into the analysis. Of the 2396 patients, 636 (26.5%) died within 30 days. Significant predictors (odds ratio and 95% confidence interval) of mortality in the multivariable analysis included patient-related factors: age (1.02, 1.01–1.03); female sex (1.34, 1.03–1.77); bedridden functional capacity (1.99, 1.24–3.21); recent hospitalisation (1.43, 1.07–1.92); concomitant corticosteroids (1.33, 1.02–1.73); and Charlson comorbidity index (1.05, 1.01–1.93). Infection-related factors were multidrug-resistant Pseudomonas (1.52, 1.15–2.1), non-urinary source (2.44, 1.54–3.85) and Sequential Organ Failure Assessment (SOFA) score (1.27, 1.18–1.36). Inappropriate empirical therapy was not associated with increased mortality (0.81, 0.49–1.33). Among 2135 patients surviving ≥48 h, hospital-acquired infection (1.59, 1.21–2.09), baseline endotracheal tube (1.63, 1.13–2.36) and ICU admission (1.53, 1.02–2.28) were additional risk factors. Risk factors for mortality among patients with P. aeruginosa were mostly irreversible. Early appropriate empirical therapy was not associated with reduced mortality. Further research should be conducted to explore subgroups that may not benefit from broad-spectrum antipseudomonal empirical therapy. Efforts should focus on prevention of infection, mainly hospital-acquired infection and multidrug-resistant pseudomonal infection.

Published
2020

11. A Contemporary Picture of Enterococcal Endocarditis

Author

Pericàs, Juan M., primary, Llopis, Jaume, additional, Muñoz, Patricia, additional, Gálvez-Acebal, Juan, additional, Kestler, Martha, additional, Valerio, Maricela, additional, Hernández-Meneses, Marta, additional, Goenaga, Miguel Á., additional, Cobo-Belaustegui, Manuel, additional, Montejo, Miguel, additional, Ojeda-Burgos, Guillermo, additional, Sousa-Regueiro, M. Dolores, additional, de Alarcón, Arístides, additional, Ramos-Martínez, Antonio, additional, Miró, José M., additional, Sánchez, Fernando Fernández, additional, Noureddine, Mariam, additional, Rosas, Gabriel, additional, de la Torre Lima, Javier, additional, Blanco, Roberto, additional, Boado, María Victoria, additional, Campaña Lázaro, Marta, additional, Crespo, Alejandro, additional, Goikoetxea, Josune, additional, Iruretagoyena, José Ramón, additional, Irurzun Zuazabal, Josu, additional, López-Soria, Leire, additional, Nieto, Javier, additional, Rodrigo, David, additional, Rodríguez, Regino, additional, Vitoria, Yolanda, additional, Voces, Roberto, additional, García López, Ma Victoria, additional, Georgieva, Radka Ivanova, additional, Ojeda, Guillermo, additional, Rodríguez Bailón, Isabel, additional, Ruiz Morales, Josefa, additional, María Cuende, Ana, additional, Echeverría, Tomás, additional, Fuerte, Ana, additional, Gaminde, Eduardo, additional, Goenaga, Miguel Ángel, additional, Idígoras, Pedro, additional, Antonio Iribarren, José, additional, Izaguirre Yarza, Alberto, additional, Kortajarena Urkola, Xabier, additional, Reviejo, Carlos, additional, Carrasco, Rafael, additional, Climent, Vicente, additional, Llamas, Patricio, additional, Merino, Esperanza, additional, Plazas, Joaquín, additional, Reus, Sergio, additional, Álvarez, Nemesio, additional, Bravo-Ferrer, José María, additional, Castelo, Laura, additional, Cuenca, José, additional, Llinares, Pedro, additional, Miguez Rey, Enrique, additional, Rodríguez Mayo, María, additional, Sánchez, Efrén, additional, Sousa Regueiro, Dolores, additional, Javier Martínez, Francisco, additional, Alonso, Ma del Mar, additional, Castro, Beatriz, additional, García Rosado, Dácil, additional, Durán, Ma del Carmen, additional, Miguel Gómez, Ma Antonia, additional, Lacalzada, Juan, additional, Nassar, Ibrahim, additional, Plata Ciezar, Antonio, additional, Reguera Iglesias, José Ma, additional, Asensi Álvarez, Víctor, additional, Costas, Carlos, additional, de la Hera, Jesús, additional, Fernández Suárez, Jonnathan, additional, Iglesias Fraile, Lisardo, additional, León Arguero, Víctor, additional, López Menéndez, José, additional, Mencia Bajo, Pilar, additional, Morales, Carlos, additional, Moreno Torrico, Alfonso, additional, Palomo, Carmen, additional, Paya Martínez, Begoña, additional, Rodríguez Esteban, Ángeles, additional, Rodríguez García, Raquel, additional, Telenti Asensio, Mauricio, additional, Almela, Manuel, additional, Ambrosioni, Juan, additional, Azqueta, Manuel, additional, Brunet, Mercè, additional, Bodro, Marta, additional, Cartañá, Ramón, additional, Falces, Carlos, additional, Fita, Guillermina, additional, Fuster, David, additional, García de la Mària, Cristina, additional, García-Pares, Delia, additional, Llopis Pérez, Jaume, additional, Marco, Francesc, additional, Moreno, Asunción, additional, Nicolás, David, additional, Ninot, Salvador, additional, Quintana, Eduardo, additional, Paré, Carlos, additional, Pereda, Daniel, additional, Pericás, Juan M., additional, Pomar, José L., additional, Ramírez, José, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Soy, Dolors, additional, Téllez, Adrián, additional, Tolosana, José M., additional, Vidal, Bárbara, additional, Vila, Jordi, additional, Adán, Iván, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Celemín, Daniel, additional, Cuerpo Caballero, Gregorio, additional, Delgado Montero, Antonia, additional, García Mansilla, Ana, additional, García Leoni, Ma Eugenia, additional, González Ramallo, Víctor, additional, Kestler Hernández, Martha, additional, Hualde, Amaia Mari, additional, Marín, Mercedes, additional, Martínez-Sellés, Manuel, additional, Rincón, Cristina, additional, Rodríguez-Abella, Hugo, additional, Rodríguez-Créixems, Marta, additional, Pinilla, Blanca, additional, Pinto, Ángel, additional, Vázquez, Pilar, additional, Verde Moreno, Eduardo, additional, Antorrena, Isabel, additional, Loeches, Belén, additional, Martín Quirós, Alejandro, additional, Moreno, Mar, additional, Ramírez, Ulises, additional, Rial Bastón, Verónica, additional, Romero, María, additional, Saldaña, Araceli, additional, Agüero Balbín, Jesús, additional, Armiñanzas Castillo, Carlos, additional, Arnaiz, Ana, additional, Arnaiz de las Revillas, Francisco, additional, Cobo Belaustegui, Manuel, additional, Fariñas, María Carmen, additional, Fariñas-Álvarez, Concepción, additional, Gómez Izquierdo, Rubén, additional, García, Iván, additional, González Rico, Claudia, additional, Gutiérrez-Cuadra, Manuel, additional, Gutiérrez Díez, José, additional, Pajarón, Marcos, additional, Parra, José Antonio, additional, Teira, Ramón, additional, Zarauza, Jesús, additional, Calderón Parra, Jorge, additional, Cobo, Marta, additional, Domínguez, Fernando, additional, Fortaleza, Alberto, additional, García Pavía, Pablo, additional, González, Jesús, additional, Fernández Cruz, Ana, additional, Múñez, Elena, additional, Ramos, Antonio, additional, Sánchez Romero, Isabel, additional, Centella, Tomasa, additional, Hermida, José Manuel, additional, Moya, José Luis, additional, Martín-Dávila, Pilar, additional, Navas, Enrique, additional, Oliva, Enrique, additional, del Río, Alejandro, additional, Rodríguez-Roda Stuart, Jorge, additional, Ruiz, Soledad, additional, Hidalgo Tenorio, Carmen, additional, Almendro Delia, Manuel, additional, Araji, Omar, additional, Barquero, José Miguel, additional, Calvo Jambrina, Román, additional, de Cueto, Marina, additional, Gálvez Acebal, Juan, additional, Méndez, Irene, additional, Morales, Isabel, additional, López-Cortés, Luis Eduardo, additional, García, Emilio, additional, Haro, Juan Luis, additional, Lepe, José Antonio, additional, López, Francisco, additional, Luque, Rafael, additional, Alonso, Luis Javier, additional, Azcárate, Pedro, additional, Azcona Gutiérrez, José Manuel, additional, Blanco, José Ramón, additional, Cabrera Villegas, Antonio, additional, García-Álvarez, Lara, additional, Oteo, José Antonio, additional, Sanz, Mercedes, additional, de Benito, Natividad, additional, Gurguí, Mercé, additional, Pacho, Cristina, additional, Pericas, Roser, additional, Pons, Guillem, additional, Álvarez, M., additional, Fernández, A.L., additional, Martínez, Amparo, additional, Prieto, A., additional, Regueiro, Benito, additional, Tijeira, E., additional, Vega, Marino, additional, Canut Blasco, Andrés, additional, Cordo Mollar, José, additional, Gainzarain Arana, Juan Carlos, additional, García Uriarte, Oscar, additional, Martín López, Alejandro, additional, Ortiz de Zárate, Zuriñe, additional, Urturi Matos, José Antonio, additional, Gloria, García-Domínguez, additional, Antonio, Sánchez-Porto, additional, Arribas Leal, José Ma, additional, García Vázquez, Elisa, additional, Hernández Torres, Alicia, additional, Blázquez, Ana, additional, de la Morena Valenzuela, Gonzalo, additional, Alonso, Ángel, additional, Aramburu, Javier, additional, Calvo, Felicitas Elena, additional, Moreno Rodríguez, Anai, additional, Tarabini-Castellani, Paola, additional, Heredero Gálvez, Eva, additional, Maicas Bellido, Carolina, additional, Largo Pau, José, additional, Sepúlveda, Ma Antonia, additional, Toledano Sierra, Pilar, additional, Iqbal-Mirza, Sadaf Zafar, additional, Cascales Alcolea, Eva, additional, Keituqwa Yañez, Ivan, additional, Martínez, Julián Navarro, additional, Ballesta, Ana Peláez, additional, Moreno Escobar, Eduardo, additional, Peña Monje, Alejandro, additional, Sánchez Cabrera, Valme, additional, Vinuesa García, David, additional, Arrizabalaga Asenjo, María, additional, Cifuentes Luna, Carmen, additional, Núñez Morcillo, Juana, additional, Pérez Seco, Ma Cruz, additional, Villoslada Gelabert, Aroa, additional, Aured Guallar, Carmen, additional, Fernández Abad, Nuria, additional, García Mangas, Pilar, additional, Matamala Adell, Marta, additional, Palacián Ruiz, Ma Pilar, additional, Porres, Juan Carlos, additional, Alcaraz Vidal, Begoña, additional, Cobos Trigueros, Nazaret, additional, Del Amor Espín, María Jesús, additional, Giner Caro, José Antonio, additional, Jiménez Sánchez, Roberto, additional, Jimeno Almazán, Amaya, additional, Ortín Freire, Alejandro, additional, Viqueira González, Monserrat, additional, Pericás Ramis, Pere, additional, Ribas Blanco, Ma Ángels, additional, Ruiz de Gopegui Bordes, Enrique, additional, Vidal Bonet, Laura, additional, Bellón Munera, Ma Carmen, additional, Escribano Garaizabal, Elena, additional, Tercero Martínez, Antonia, additional, Segura Luque, Juan Carlos, additional, Badía, Cristina, additional, Boix Palop, Lucía, additional, Xercavins, Mariona, additional, Ibars, Sónia, additional, Nebreda, Eloy Gómez, additional, Horcajada Herrera, Ibalia, additional, Menduiña Gallego, Irene, additional, Marrero Santiago, Héctor, additional, de Miguel Martínez, Isabel, additional, Pisos Álamo, Elena, additional, Díaz Pedroche, Carmen, additional, Chaves, Fernando, additional, de Cossío, Santiago, additional, López Medrano, Francisco, additional, López, Ma Jesús, additional, Solera, Javier, additional, Solís, Jorge, additional, Ardanuy, Carmen, additional, Cuervo Requena, Guillermo, additional, Grillo, Sara, additional, and Ruiz Majoral, Alejandro, additional

Published
2020
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12. Role of age and comorbidities in mortality of patients with infective endocarditis

Author

Armiñanzas Castillo, Carlos, Fariñas-Álvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez-Sellés, Manuel, Miró, José María, Pericás Pulico, Juan Manuel, Goenaga Sánchez, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez-Álvarez, Regino José, Moreno, Asunción, Morales, Carlos, Montejo, Miguel, Largo Pau, José, Cascales Alcolea, Eva, Ruiz de Gopegui Bordes, Enrique, Vinuesa García, David, Viqueira González, Monserrat, Goikoetxea-Aguirre, Josune, Azqueta, Manuel, Rosas, Gabriel, Fuster, David, Paya Martínez, Begoña, Marín-Arriaza, Mercedes, Arrizabalaga Asenjo, María, Loeches, Belén, Sarralde, Aurelio, Pajarón, Marcos, Alonso, Mª. del Mar, Gutiérrez-Cuadra, Manuel, Sepúlveda, M. A., Alcaraz Vidal, Begoña, Azcárate, Pedro, Fariñas, María del Carmen, López-Cortés, Luis Eduardo, Sitges, Marta, Cifuentes Luna, Carmen, Barquero, José M., Rodrigo, David, Gutiérrez Díez, José, Almendro Delia, Manuel, Río, A. del, Pericas, Roser, Pacho, Cristina, Núñez Morcillo, Juana, Agüero, Jesús, Aured Guallar, Carmen, Celemín, Daniel, Paré, Carlos, Llamas, Patricio, García Rosado, Dácil, Palomo, Carmen, Araji, Omar, García, Iván, Oteo, José Antonio, Giner Caro, José Antonio, Benito, Natividad, Canut, Andrés, Vidal Bonet, Laura, Ramos, Antonio, Rodríguez, David, Menárguez, Mª. Cruz, Castelo Corral, Laura, Echeverría, Tomás, García-López, María Victoria, Plazas, Joaquín, Pereda, Daniel, Fuerte, Ana, Rincón, Cristina, Aramendi, José, Prieto, A., Alonso, Ángel, Menéndez, José López, Blázquez, Ana, Rodríguez, Regino, Blanco, José Ramón, López, Francisco, Gaminde, Eduardo, Noureddine, Mariam, Jiménez Sánchez, Roberto, Miguel Gómez, Mª. Antonia, Durán, Mª. del Carmen, Rodríguez-García, Raquel, Reus, Sergio, Álvarez, Nemesio, Hermida, José Manuel, Porres, Juan Carlos, Sanz, Mercedes, Sánchez-Porto, Antonio, Soriano, Víctor, Hernández Torres, Alicia, Brunet, Mercè, Keituqwa Yañez, Iván, Idígoras, Pedro, Pons, Guillem, Bravo-Ferrer, José, Luque-Márquez, Rafael, Cueto, Marina de, Teira Cobo, Ramón, Castelo, Laura, Crespo, Alejandro, Lacalzada, Juan, Rodríguez Mayo, María, Iqbal-Mirza, Sadaf Zafar, Almela, Manel, Ramírez, José, Nassar, Ibrahim, Moya, José Luis, Ruiz, Soledad, Torre, Javier de la, Regueiro, Benito, Toledano Sierra, Pilar, Arribas, José Ramón, Egea Serrano, Pilar, Téllez, Adrián, Rial Bastón, Verónica, Cobos-Trigueros, Nazaret, Cuenca, José, Irurzun Zuazabal, Josu, Marco, Francesc, Plata-Ciezar, Antonio, Alonso, Luis Javier, Reguera-Iglesias, J. M., Matamala Adell, Marta, García Pavía, Pablo, Abad, Nuria Fernández, Hera, Jesús de la, Pérez Seco, Mª. Cruz, López-Soria, Leire, Asensi, Víctor, Aramburu, Javier, Bereciartúa, Elena, Gurguí, Mercè, Bodro, Marta, Rodríguez-Abella, Hugo, García Mansilla, Ana, García Mangas, Pilar, Gálvez-Acebal, Juan, Bellón Munera, Mª. Carmen, Ruiz Morales, Josefa, Tercero Martínez, Antonia, Rodríguez Bailón, Isabel, Cartañá, Ramón, Peña Monje, Alejandro, García-de-la-Mària, Cristina, Vega, Marino, Vidal, Bárbara, Saldaña, Araceli, Rodríguez-Créixems, Marta, Alarcón González, Arístides de, Martínez-Marcos, Francisco Javier, Cordo Mollar, José, Ninot, Salvador, Vitoria, Yolanda, Parra, José Antonio, Carrasco, Rafael, Vila, Jordi, Ortín Freire, Alejandro, García Leoni, Mª. Eugenia, Izaguirre Yarza, Alberto, Orden, Beatriz, Amado, Cristina, Pinilla, Blanca, Pinto, A., Mencia Bajo, Pilar, Escribano Garaizabal, Elena, Iribarren, José A., Castro, Beatriz, Calvo Jambrina, Román, Martín-Dávila, Pilar, Martínez, Francisco Javier, Kestler Hernández, Martha, Nieto, Javier, Valerio, Maricela, Iruretagoyena, José Ramón, Hernández Roca, José Joaquín, Vázquez, Pilar, Pomar, José L., Martín Quirós, Alejandro, Miguez Rey, Enrique, Centella, Tomasa, Lepe, José A., Arnaiz, A., Villoslada Gelabert, Aroa, Nicolás, David, Voces, Roberto, Llinares, Pedro, Rodríguez Esteban, Ángeles, Sánchez, Efrén, Azcona-Gutiérrez, José Manuel, Morena Valenzuela, Gonzalo de la, Moreno Torrico, Alfonso, Verde Moreno, Eduardo, Cuende, Ana María, Cobo Belaustegui, Manuel, Pericás Ramis, Pere, Gómez Izquierdo, Rubén, León Arguero, Víctor, Peláez Ballesta, Ana, Fernández Suárez, Jonathan, González-Rico, Claudia, Morales, Isabel, Soy, Dolors, Merino, Esperanza, Quintana, Eduardo, Segura Luque, Juan Carlos, Navas, Enrique, Gainzarain Arana, Juan Carlos, Álvarez, M., Iglesias Fraile, Lisardo, Hernández-Meneses, Marta, Falces, Carlos, Delgado Montero, Antonia, Cuerpo Caballero, Gregorio, Oliva, Enrique, Kortajarena Urkola, Xabier, Hidalgo-Tenorio, Carmen, Ivanova-Georgieva, Radka, Blanco, María José, Campaña Lázaro, Marta, García Uriarte, Óscar, Amor Espín, María Jesús Del, Llopis, Jaume, Costas, Carlos, Adán, Iván, García, Emilio, Bouza Santiago, Emilio, Muñoz García, Patricia, García-Álvarez, Lara, Telenti Asensio, Mauricio, Fernández, A.L., Reviejo, Carlos, Blanco, Roberto, Moreno Escobar, Eduardo, Tijeira, E., Calvo, Felicitas Elena, Martín López, Alejandro, Boado, María Victoria, Climent, Vicente, Fita, Guillermina, Mari Hualde, Amaia, Romero, María, Palacián Ruiz, Mª. Pilar, Ramírez, Ulises, Martínez, Amparo, Tolosana, José M., Ortiz de Zárate, Zuriñe, Rovira, Irene, Sousa Regueiro, Dolores, Urturi Matos, José Antonio, Haro, Juan Luis, Moreno-Rodríguez, Anai, García Vázquez, Elisa, Sánchez Cabrera, Valme, Jimeno Almazán, Amaya, Tarabini-Castellani, Paola, Ambrosioni, Juan, Méndez, Irene, Bermejo, Javier, Antorrena Miranda, Isabel, González, Jesús, Moreno, Mar, Ribas Blanco, Mª. Ángels, Domínguez, Fernando, García Domínguez, Gloria, Fernández Cruz, Ana, Heredero Gálvez, Eva, Sandoval, Elena, Maicas Bellido, Carolina, Armiñanzas Castillo, Carlos, Fariñas-Álvarez, Concepción, Zarauza, Jesús, Muñoz, Patricia, González Ramallo, Víctor, Martínez-Sellés, Manuel, Miró, José María, Pericás Pulico, Juan Manuel, Goenaga Sánchez, Miguel Ángel, Ojeda Burgos, Guillermo, Rodríguez-Álvarez, Regino José, Moreno, Asunción, Morales, Carlos, Montejo, Miguel, Largo Pau, José, Cascales Alcolea, Eva, Ruiz de Gopegui Bordes, Enrique, Vinuesa García, David, Viqueira González, Monserrat, Goikoetxea-Aguirre, Josune, Azqueta, Manuel, Rosas, Gabriel, Fuster, David, Paya Martínez, Begoña, Marín-Arriaza, Mercedes, Arrizabalaga Asenjo, María, Loeches, Belén, Sarralde, Aurelio, Pajarón, Marcos, Alonso, Mª. del Mar, Gutiérrez-Cuadra, Manuel, Sepúlveda, M. A., Alcaraz Vidal, Begoña, Azcárate, Pedro, Fariñas, María del Carmen, López-Cortés, Luis Eduardo, Sitges, Marta, Cifuentes Luna, Carmen, Barquero, José M., Rodrigo, David, Gutiérrez Díez, José, Almendro Delia, Manuel, Río, A. del, Pericas, Roser, Pacho, Cristina, Núñez Morcillo, Juana, Agüero, Jesús, Aured Guallar, Carmen, Celemín, Daniel, Paré, Carlos, Llamas, Patricio, García Rosado, Dácil, Palomo, Carmen, Araji, Omar, García, Iván, Oteo, José Antonio, Giner Caro, José Antonio, Benito, Natividad, Canut, Andrés, Vidal Bonet, Laura, Ramos, Antonio, Rodríguez, David, Menárguez, Mª. Cruz, Castelo Corral, Laura, Echeverría, Tomás, García-López, María Victoria, Plazas, Joaquín, Pereda, Daniel, Fuerte, Ana, Rincón, Cristina, Aramendi, José, Prieto, A., Alonso, Ángel, Menéndez, José López, Blázquez, Ana, Rodríguez, Regino, Blanco, José Ramón, López, Francisco, Gaminde, Eduardo, Noureddine, Mariam, Jiménez Sánchez, Roberto, Miguel Gómez, Mª. Antonia, Durán, Mª. del Carmen, Rodríguez-García, Raquel, Reus, Sergio, Álvarez, Nemesio, Hermida, José Manuel, Porres, Juan Carlos, Sanz, Mercedes, Sánchez-Porto, Antonio, Soriano, Víctor, Hernández Torres, Alicia, Brunet, Mercè, Keituqwa Yañez, Iván, Idígoras, Pedro, Pons, Guillem, Bravo-Ferrer, José, Luque-Márquez, Rafael, Cueto, Marina de, Teira Cobo, Ramón, Castelo, Laura, Crespo, Alejandro, Lacalzada, Juan, Rodríguez Mayo, María, Iqbal-Mirza, Sadaf Zafar, Almela, Manel, Ramírez, José, Nassar, Ibrahim, Moya, José Luis, Ruiz, Soledad, Torre, Javier de la, Regueiro, Benito, Toledano Sierra, Pilar, Arribas, José Ramón, Egea Serrano, Pilar, Téllez, Adrián, Rial Bastón, Verónica, Cobos-Trigueros, Nazaret, Cuenca, José, Irurzun Zuazabal, Josu, Marco, Francesc, Plata-Ciezar, Antonio, Alonso, Luis Javier, Reguera-Iglesias, J. M., Matamala Adell, Marta, García Pavía, Pablo, Abad, Nuria Fernández, Hera, Jesús de la, Pérez Seco, Mª. Cruz, López-Soria, Leire, Asensi, Víctor, Aramburu, Javier, Bereciartúa, Elena, Gurguí, Mercè, Bodro, Marta, Rodríguez-Abella, Hugo, García Mansilla, Ana, García Mangas, Pilar, Gálvez-Acebal, Juan, Bellón Munera, Mª. Carmen, Ruiz Morales, Josefa, Tercero Martínez, Antonia, Rodríguez Bailón, Isabel, Cartañá, Ramón, Peña Monje, Alejandro, García-de-la-Mària, Cristina, Vega, Marino, Vidal, Bárbara, Saldaña, Araceli, Rodríguez-Créixems, Marta, Alarcón González, Arístides de, Martínez-Marcos, Francisco Javier, Cordo Mollar, José, Ninot, Salvador, Vitoria, Yolanda, Parra, José Antonio, Carrasco, Rafael, Vila, Jordi, Ortín Freire, Alejandro, García Leoni, Mª. Eugenia, Izaguirre Yarza, Alberto, Orden, Beatriz, Amado, Cristina, Pinilla, Blanca, Pinto, A., Mencia Bajo, Pilar, Escribano Garaizabal, Elena, Iribarren, José A., Castro, Beatriz, Calvo Jambrina, Román, Martín-Dávila, Pilar, Martínez, Francisco Javier, Kestler Hernández, Martha, Nieto, Javier, Valerio, Maricela, Iruretagoyena, José Ramón, Hernández Roca, José Joaquín, Vázquez, Pilar, Pomar, José L., Martín Quirós, Alejandro, Miguez Rey, Enrique, Centella, Tomasa, Lepe, José A., Arnaiz, A., Villoslada Gelabert, Aroa, Nicolás, David, Voces, Roberto, Llinares, Pedro, Rodríguez Esteban, Ángeles, Sánchez, Efrén, Azcona-Gutiérrez, José Manuel, Morena Valenzuela, Gonzalo de la, Moreno Torrico, Alfonso, Verde Moreno, Eduardo, Cuende, Ana María, Cobo Belaustegui, Manuel, Pericás Ramis, Pere, Gómez Izquierdo, Rubén, León Arguero, Víctor, Peláez Ballesta, Ana, Fernández Suárez, Jonathan, González-Rico, Claudia, Morales, Isabel, Soy, Dolors, Merino, Esperanza, Quintana, Eduardo, Segura Luque, Juan Carlos, Navas, Enrique, Gainzarain Arana, Juan Carlos, Álvarez, M., Iglesias Fraile, Lisardo, Hernández-Meneses, Marta, Falces, Carlos, Delgado Montero, Antonia, Cuerpo Caballero, Gregorio, Oliva, Enrique, Kortajarena Urkola, Xabier, Hidalgo-Tenorio, Carmen, Ivanova-Georgieva, Radka, Blanco, María José, Campaña Lázaro, Marta, García Uriarte, Óscar, Amor Espín, María Jesús Del, Llopis, Jaume, Costas, Carlos, Adán, Iván, García, Emilio, Bouza Santiago, Emilio, Muñoz García, Patricia, García-Álvarez, Lara, Telenti Asensio, Mauricio, Fernández, A.L., Reviejo, Carlos, Blanco, Roberto, Moreno Escobar, Eduardo, Tijeira, E., Calvo, Felicitas Elena, Martín López, Alejandro, Boado, María Victoria, Climent, Vicente, Fita, Guillermina, Mari Hualde, Amaia, Romero, María, Palacián Ruiz, Mª. Pilar, Ramírez, Ulises, Martínez, Amparo, Tolosana, José M., Ortiz de Zárate, Zuriñe, Rovira, Irene, Sousa Regueiro, Dolores, Urturi Matos, José Antonio, Haro, Juan Luis, Moreno-Rodríguez, Anai, García Vázquez, Elisa, Sánchez Cabrera, Valme, Jimeno Almazán, Amaya, Tarabini-Castellani, Paola, Ambrosioni, Juan, Méndez, Irene, Bermejo, Javier, Antorrena Miranda, Isabel, González, Jesús, Moreno, Mar, Ribas Blanco, Mª. Ángels, Domínguez, Fernando, García Domínguez, Gloria, Fernández Cruz, Ana, Heredero Gálvez, Eva, Sandoval, Elena, and Maicas Bellido, Carolina

Abstract

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group.

Published
2019

13. Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse

Author

Zegri-Reiriz, Isabel, primary, de Alarcón, Arístides, additional, Muñoz, Patricia, additional, Martínez Sellés, Manuel, additional, González-Ramallo, Victor, additional, Miro, Jose M., additional, Falces, Carles, additional, Gonzalez Rico, Claudia, additional, Kortajarena Urkola, Xabier, additional, Lepe, José Antonio, additional, Rodriguez Alvarez, Regino, additional, Reguera Iglesias, Jose Maria, additional, Navas, Enrique, additional, Dominguez, Fernando, additional, Garcia-Pavia, Pablo, additional, Fernández Sánchez, Fernando, additional, Noureddine, Mariam, additional, Rosas, Gabriel, additional, de la Torre Lima, Javier, additional, Aramendi, José, additional, Bereciartua, Elena, additional, Blanco, María José, additional, Blanco, Roberto, additional, Boado, María Victoria, additional, Campaña Lázaro, Marta, additional, Crespo, Alejandro, additional, Goikoetxea, Josune, additional, Iruretagoyena, José Ramón, additional, Irurzun Zuazabal, Josu, additional, López-Soria, Leire, additional, Montejo, Miguel, additional, Nieto, Javier, additional, Rodrigo, David, additional, Rodríguez, David, additional, Rodríguez, Regino, additional, Vitoria, Yolanda, additional, Voces, Roberto, additional, García López, María Victoria, additional, Ivanova Georgieva, Radka, additional, Ojeda, Guillermo, additional, Rodríguez Bailón, Isabel, additional, Ruiz Morales, Josefa, additional, Cuende, Ana María, additional, Echeverría, Tomás, additional, Fuerte, Ana, additional, Gaminde, Eduardo, additional, Goenaga, Miguel Ángel, additional, Idígoras, Pedro, additional, Iribarren, José Antonio, additional, Izaguirre Yarza, Alberto, additional, Reviejo, Carlos, additional, Carrasco, Rafael, additional, Climent, Vicente, additional, Llamas, Patricio, additional, Merino, Esperanza, additional, Plazas, Joaquín, additional, Reus, Sergio, additional, Álvarez, Nemesio, additional, Bravo-Ferrer, José María, additional, Castelo, Laura, additional, Cuenca, José, additional, Llinares, Pedro, additional, Miguez Rey, Enrique, additional, Rodríguez Mayo, María, additional, Sánchez, Efrén, additional, Sousa Regueiro, Dolores, additional, Martínez, Francisco Javier, additional, Alonso, María del Mar, additional, Castro, Beatriz, additional, García Rosado, Dácil, additional, Durán, Mª del Carmen, additional, Miguel Gómez, Mª Antonia, additional, Lacalzada, Juan, additional, Nassar, Ibrahim, additional, Plata Ciezar, Antonio, additional, Reguera Iglesias, José Mª, additional, Asensi Álvarez, Víctor, additional, Costas, Carlos, additional, de la Hera, Jesús, additional, Fernández Suárez, Jonnathan, additional, Iglesias Fraile, Lisardo, additional, León Arguero, Víctor, additional, López Menéndez, José, additional, Mencia Bajo, Pilar, additional, Morales, Carlos, additional, Moreno Torrico, Alfonso, additional, Palomo, Carmen, additional, Paya Martínez, Begoña, additional, Rodríguez Esteban, Ángeles, additional, Rodríguez García, Raquel, additional, Telenti Asensio, Mauricio, additional, Almela, Manuel, additional, Ambrosioni, Juan, additional, Azqueta, Manuel, additional, Brunet, Mercè, additional, Bodro, Marta, additional, Cartañá, Ramón, additional, Falces, Carlos, additional, Fita, Guillermina, additional, Fuster, David, additional, García de la Mària, Cristina, additional, Hernández-Meneses, Marta, additional, Llopis Pérez, Jaume, additional, Marco, Francesc, additional, Miró, José María, additional, Moreno, Asunción, additional, Nicolás, David, additional, Ninot, Salvador, additional, Quintana, Eduardo, additional, Paré, Carlos, additional, Pereda, Daniel, additional, Pericás, Juan Manuel, additional, Pomar, José Luis, additional, Ramírez, José, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Soy, Dolors, additional, Téllez, Adrián, additional, Tolosana, José M., additional, Vidal, Bárbara, additional, Vila, Jordi, additional, Adán, Iván, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Celemín, Daniel, additional, Cuerpo Caballero, Gregorio, additional, Delgado Montero, Antonia, additional, Fernández Cruz, Ana, additional, García Mansilla, Ana, additional, García Leoni, María Eugenia, additional, González Ramallo, Víctor, additional, Kestler Hernández, Martha, additional, Hualde, Amaia Mari, additional, Marín, Mercedes, additional, Martínez-Sellés, Manuel, additional, Menárguez, María Cruz, additional, Rincón, Cristina, additional, Rodríguez-Abella, Hugo, additional, Rodríguez-Créixems, Marta, additional, Pinilla, Blanca, additional, Pinto, Ángel, additional, Valerio, Maricela, additional, Vázquez, Pilar, additional, Verde Moreno, Eduardo, additional, Antorrena, Isabel, additional, Loeches, Belén, additional, Martín Quirós, Alejandro, additional, Moreno, Mar, additional, Ramírez, Ulises, additional, Rial Bastón, Verónica, additional, Romero, María, additional, Saldaña, Araceli, additional, Agüero Balbín, Jesús, additional, Armiñanzas Castillo, Carlos, additional, Arnaiz, Ana, additional, Arnaiz de las Revillas, Francisco, additional, Cobo Belaustegui, Manuel, additional, Fariñas, María Carmen, additional, Fariñas-Álvarez, Concepción, additional, Gómez Izquierdo, Rubén, additional, García, Iván, additional, González Rico, Claudia, additional, Gutiérrez-Cuadra, Manuel, additional, Gutiérrez Díez, José, additional, Pajarón, Marcos, additional, Parra, José Antonio, additional, Teira, Ramón, additional, Zarauza, Jesús, additional, Domínguez, Fernando, additional, García-Pavía, Pablo, additional, Mirelis, Jesús González, additional, Orden, Beatriz, additional, Ramos, Antonio, additional, Cobo-Marcos, Marta, additional, Centella, Tomasa, additional, Hermida, José Manuel, additional, Moya, José Luis, additional, Martín-Dávila, Pilar, additional, Oliva, Enrique, additional, del Río, Alejandro, additional, Ruiz, Soledad, additional, Hidalgo Tenorio, Carmen, additional, Almendro Delia, Manuel, additional, Araji, Omar, additional, Barquero, José Miguel, additional, Calvo Jambrina, Román, additional, de Cueto, Marina, additional, Gálvez Acebal, Juan, additional, Méndez, Irene, additional, Morales, Isabel, additional, López-Cortés, Luis Eduardo, additional, García, Emilio, additional, Haro, Juan Luis, additional, López, Francisco, additional, Luque, Rafael, additional, Alonso, Luis Javier, additional, Azcárate, Pedro, additional, Azcona Gutiérrez, José Manuel, additional, Blanco, José Ramón, additional, García-Álvarez, Lara, additional, Oteo, José Antonio, additional, Sanz, Mercedes, additional, de Benito, Natividad, additional, Gurguí, Mercé, additional, Pacho, Cristina, additional, Pericas, Roser, additional, Pons, Guillem, additional, Fernández, Ángel Luis, additional, Martínez, Amparo, additional, Prieto, Arturo, additional, Regueiro, Benito, additional, Vega, Marino, additional, Blasco, Andrés Canut, additional, Mollar, José Cordo, additional, Gainzarain Arana, Juan Carlos, additional, García Uriarte, Oscar, additional, Martín López, Alejandro, additional, Ortiz de Zárate, Zuriñe, additional, Urturi Matos, José Antonio, additional, García Domínguez, Gloria, additional, Sánchez-Porto, Antonio, additional, Arribas Leal, José Mª, additional, García Vázquez, Elisa, additional, Hernández Torres, Alicia, additional, Blázquez, Ana, additional, de la Morena Valenzuela, Gonzalo, additional, Alonso, Ángel, additional, Aramburu, Javier, additional, Calvo, Felicitas Elena, additional, Moreno Rodríguez, Anai, additional, Tarabini-Castellani, Paola, additional, Heredero Gálvez, Eva, additional, Maicas Bellido, Carolina, additional, Largo Pau, José, additional, Sepúlveda, María Antonia, additional, Toledano Sierra, Pilar, additional, Iqbal-Mirza, Sadaf Zafar, additional, Cascales Alcolea, Eva, additional, Egea Serrano, Pilar, additional, Hernández Roca, José Joaquín, additional, Keituqwa Yañez, Ivan, additional, Peláez Ballesta, Ana, additional, Soriano, Víctor, additional, Moreno Escobar, Eduardo, additional, Peña Monje, Alejandro, additional, Sánchez Cabrera, Valme, additional, Vinuesa García, David, additional, Arrizabalaga Asenjo, María, additional, Cifuentes Luna, Carmen, additional, Núñez Morcillo, Juana, additional, Pérez Seco, Mª Cruz, additional, Villoslada Gelabert, Aroa, additional, Aured Guallar, Carmen, additional, Fernández Abad, Nuria, additional, García Mangas, Pilar, additional, Matamala Adell, Marta, additional, Palacián Ruiz, Mª Pilar, additional, Porres, Juan Carlos, additional, Alcaraz Vidal, Begoña, additional, Cobos Trigueros, Nazaret, additional, Del Amor Espín, María Jesús, additional, Giner Caro, José Antonio, additional, Jiménez Sánchez, Roberto, additional, Jimeno Almazán, Amaya, additional, Ortín Freire, Alejandro, additional, Viqueira González, Monserrat, additional, Pericás Ramis, Pere, additional, Ribas Blanco, Mª Ángels, additional, Ruiz de Gopegui Bordes, Enrique, additional, Vidal Bonet, Laura, additional, Bellón Munera, Mª Carmen, additional, Escribano Garaizabal, Elena, additional, Tercero Martínez, Antonia, additional, and Segura Luque, Juan Carlos, additional

Published
2018
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14. Epidemiologia molecular y resistencia a los antimicrobianos en Staphylococcus spp. en centros sanitarios de Mallorca durante los últimos 15 años (1999-2013)

Author

Ruiz de Gopegui Bordes, Enrique, Oliver Palomo, Antonio, Pérez Sáenz, José Luis, and Universitat de les Illes Balears. Departament de Biologia

Subjects
Methicillin-resistant Staphylococcus aureus, Majorca, Epidemiology, Panton-Valentine leucocidin, Geriatrics, Long-term care, Staphylococcus hominis, Linezolid resistance, 23S rRNA, cfr, Plasmid, Conjugation, Staphylococcus aureus resistent a la meticil·lina, Mallorca, Epidemiologia, Leucocidina de Panton-Valentine, Residència geriàtrica, Staphylococcus hominis, Resistència a la linezolida, ARNr 23S, cfr, Plasmidi, Conjugació, Microbiología clínica, Staphylococcus aureus resistente a la meticilina, Mallorca, Epidemiología, Leucocidina de Panton-Valentine, Residencia geriátrica, Staphylococcus hominis, Resistencia a la linezolida, ARNr 23S, cfr, Plásmido, Conjugación
Abstract

Introducción Las primeras cepas de Staphylococcus aureus resistentes a la meticilina (SARM) se detectaron en el Reino Unido en 1960. Posteriormente, se diseminaron por todo el mundo. Al principio, el SARM era un patógeno nosocomial; pero, progresivamente, se fue extendiendo a pacientes no ingresados, la mayoría de ellos relacionados con el sistema sanitario, como es el caso de los residentes geriátricos. A partir del año 2000, se detectaron cepas de SARM comunitario, con características clínicas y microbiológicas peculiares, como la presencia de genes codificantes de la leucocidina de Panton-Valentine (LPV). Uno de los antimicrobianos alternativos para tratar el SARM es la linezolida, pero se han detectado cepas de estafilococos resistentes a este antimicrobiano. Objetivos Estudiar la relación clonal de los aislados de SARM detectados en el Hospital Universitari Son Dureta-Son Espases, hospital de referencia de las Islas Baleares, durante cuatro períodos: 1999-2000, 2002-2004, 2008 y 2012-2013. Comparar la relación clonal de los aislados de SARM del hospital de referencia con los de otros hospitales de Mallorca. Determinar la frecuencia de LPV. Estudiar la prevalencia de la colonización por SARM en exudados nasales y de úlcera de los residentes en el mayor centro geriátrico de Mallorca. Determinar los factores de riesgo de colonización y evaluar su evolución temporal. Estudiar la epidemiología molecular y el mecanismo de resistencia a la linezolida en cepas de SARM, Staphylococcus epidermidis y Staphylococcus hominis, resistentes a este antimicrobiano detectadas en dos hospitales de Mallorca. Metodología Se documentaron todos los pacientes con SARM en muestras clínicas en los cuatro períodos de estudio. La relación clonal se determinó mediante electroforesis en campo pulsado y multilocus sequence typing. Se realizaron diversos ensayos de PCR para la detección de los genes de LPV, tipificación del casete cromosómico estafilocócico mec (SCCmec) y subtipificación del SCCmec tipo IV. En el estudio de prevalencia de SARM en geriátricos, se recogieron muestras de exudado nasal y de úlcera durante los meses de octubre y noviembre de 2005. Para determinar los factores de riesgo de colonización, se cumplimentó un formulario estandarizado con datos clínicos de cada participante. Se realizó seguimiento clínico y de la colonización a los 8, 12 y 18 meses, tanto en los pacientes colonizados por SARM (casos), como en un grupo de residentes no colonizados (controles). En los aislados de SARM, S. epidermidis y S. hominis resistentes a la linezolida, se realizaron diversos ensayos de PCR y de transferencia del plásmido. Se procedió a la caracterización del plásmido de multirresistencia (pERGB) tras la clonación de los distintos fragmentos en pUCP24. Resultados y conclusiones La situación epidemiológica de SARM en nuestro hospital se caracterizó por la presencia endémica de 3 clones mayoritarios en 1999-2004 (ST125-IVc, ST228-I y ST22-IVh). Los clones ST125-IVc y ST228-I predominaban también en muchos hospitales españoles, mientras que el ST22-IVh (EMRSA-15), prevalente en el Reino Unido, era prácticamente inexistente en el territorio peninsular español. Estos tres clones predominaban en otros hospitales de Mallorca. En 2008, un 7% de las cepas de SARM hospitalarias fueron productoras de LPV. La prevalencia de SARM en exudados nasales de los residentes geriátricos fue del 8%, relativamente baja y generalmente transitoria. Los factores de riesgo asociados con la colonización fueron el ingreso hospitalario previo, la enfermedad vascular, la diabetes, la presencia de úlceras de decúbito y el tratamiento antibiótico previo. La gran mayoría de residentes colonizados no desarrollaron una infección subsiguiente por SARM. Se detectó la presencia de dos clones distintos, también encontrados en el hospital de referencia. Por primera vez, se describe un plásmido de multirresistencia conjugativo portador de los genes cfr, ant(4’)-Ia, tet(L) y dfrK en S. aureus y S. epidermidis que determina la resistencia a la linezolida y a otros antibióticos. Todas las cepas de S. hominis resistentes a la linezolida pertenecían al mismo clon y presentaban la mutación G2576T en el gen ARNr 23S., Introducció Les primeres soques de Staphylococcus aureus resistents a la meticil·lina (SARM) es detectaren al Regne Unit l’any 1960. Posteriorment, es disseminaren per tot el món. Al començament, el SARM era un patogen nosocomial; però, progressivament, es va estendre a malalts no ingressats, la majoria d’ells relacionats amb el sistema sanitari, com ara els residents geriàtrics. A partir de l’any 2000, es detectaren soques de SARM comunitari, amb característiques clíniques i microbiològiques peculiars, com la presència de gens codificants de la leucocidina de Panton-Valentine (LPV). Un dels antimicrobians alternatius per tractar el SARM és la linezolida, encara que també s’han detectat soques d’estafilococs resistents a aquest antimicrobià. Objectius Estudiar la relació clonal dels aïllats de SARM detectats a l’Hospital Universitari Son Dureta-Son Espases, hospital de referència de les Illes Balears, durant quatre períodes: 1999-2000, 2002-2004, 2008 i 2012-2013. Comparar la relació clonal dels aïllats de SARM de l’hospital de referència amb els d’altres hospitals de Mallorca. Determinar la freqüència de LPV. Estudiar la prevalença de la colonització per SARM en exsudats nasals i d’úlcera dels residents al centre geriàtric més gran de Mallorca. Determinar els factors de risc d’aquesta colonització i avaluar-ne l’evolució temporal. Estudiar l’epidemiologia molecular i el mecanisme de resistència a la linezolida en soques de SARM, Staphylococcus epidermidis i Staphylococcus hominis, resistents a aquest antimicrobià detectades a dos hospitals de Mallorca. Metodologia Es documentaren tots els malalts amb SARM detectat en mostres clíniques durant els quatre períodes d’estudi. La relació clonal es determinà mitjançant electroforesi en camp polsant i multilocus sequence typing. Es dugueren a terme diferents assajos de PCR per a la detecció dels gens de LPV, tipificació del casset cromosòmic estafilocòccic mec (SCCmec) i subtipificació de l’SCCmec tipus IV. A l’estudi de prevalença de SARM en geriàtrics, es recolliren exsudats nasals i d’úlcera durant els mesos d’octubre i novembre de 2005. Per determinar els factors de risc de colonització, s’emplenà un formulari estandarditzat amb les dades clíniques de cada participant. Es va fer el seguiment clínic i de la colonització als 8, 12 i 18 mesos, tant en els malalts colonitzats per SARM (casos), com en un grup de residents no colonitzats (controls). En els aïllats de SARM, S. epidermidis i S. hominis resistents a la linezolida, s’efectuaren diversos assajos de PCR i de transferència del plasmidi. Es procedí a la caracterització del plasmidi de multiresistència (pERGB) després de la clonació dels diferents fragments en pUCP24. Resultats i conclusions La situació epidemiològica de SARM al nostre hospital es caracteritza per la presència endèmica de 3 clons majoritaris en 1999-2004 (ST125-IVc, ST228-I i ST22-IVh). Els clons ST125-IVc i ST228-I predominaven també en molts hospitals espanyols mentre que el ST22-IVh (EMRSA-15), prevalent al Regne Unit, era pràcticament inexistent en el territori peninsular espanyol. Aquests tres clons van ser els més freqüents en els altres hospitals de Mallorca. L’any 2008, un 7% de les soques de SARM de l’hospital foren productores de LPV. La prevalença de SARM en exsudats nasals dels residents geriàtrics fou del 8%, relativament baixa i generalment transitòria. Els factors de risc associats amb la colonització foren l’ingrés hospitalari previ, la malaltia vascular, la diabetis, la presència d’úlceres de decúbit i el tractament antibiòtic previ. La gran majoria dels residents colonitzats no desenvoluparen una infecció subsegüent per SARM. Es detectà la presència dos clons diferents, trobats també a l’hospital de referència. Per primera vegada, es descriu un plasmidi de multiresistència conjugatiu portador dels gens cfr, ant(4’)-Ia, tet(L) i dfrK en S. aureus i S. epidermidis que determina la resistència a la linezolida i a altres antimicrobians. Totes les soques de S. hominis resistents a la linezolida pertanyien al mateix clon i presentaven la mutació G2576T al gen ARNr 23S., Introduction Methicillin-resistant Staphylococcus aureus (MRSA) strains were first detected in the United Kingdom in the sixties of the past century, and then spread all over the world. At the beginning, MRSA behaved as nosocomial pathogen but progressively was detected outside the hospital, mostly in health-care associated patients. Since year 2000, community-acquired MRSA strains showing a particular clinical and microbiological profile emerged; most of these strains typically contain two genes encoding the Panton-Valentine leucocidin (PVL). Linezolid is a useful alternative for treating patients with staphylococcal infections but resistance to this antimicrobial has arisen. Objectives To study the clonal relatedness of MRSA isolates detected at the Hospital Universitari Son Dureta-Son Espases, along four periods: 1999-2000, 2002-2004, 2008, and 2012-2013; to compare the clonal relatedness of these MRSA isolates with those from other Majorcan hospitals; to determine the frequency of PVL gene detection in the MRSA strains. To study the prevalence of MRSA colonization (nasal and ulcer swabs) in the residents admitted at the major geriatric center of Majorca. To determine the risk factors for colonization, and to evaluate its evolution in over time. To study the molecular epidemiology and the mechanisms of resistance in linezolid-resistant MRSA, Staphylococcus epidermidis and Staphylococcus hominis strains detected at two Majorcan hospitals. Methodology Clonal relatedness was determined by pulsed-field gel electrophoresis and multilocus sequence typing. Several PCR assays were carried out for detection of PVL genes, typing of staphylococcal chromosomal cassette mec (SCCmec), and subtyping of SCCmec type IV isolates. Regarding the prevalence of MRSA carriage in geriatric patients, nasal and ulcer swabs were collected from the study participants in October-November 2005. In order to determine the risk factors for MRSA colonization, a standardized questionnaire with clinical data from each resident was completed. Two cohorts of residents (MRSA carriers and non-carriers) were followed up to 18 months, with nasal cultures performed every six months. PCR detection of several genes and plasmid transfer assays were done in MRSA, S. epidermidis and S. hominis linezolid-resistant isolates to decipher the determinants of this resistance. The multidrug resistance plasmid (pERGB) was characterized after cloning different gene fragments in pUCP24. Results and conclusions The epidemiologic profile of MRSA strains from our hospital was characterized for the endemic presence of 3 major clones during 1999-2004 (ST125-IVc, ST228-I and ST22-IVh). The ST125-IVc and ST228-I clones were also predominant in many Spanish hospitals at that time, whereas the ST22-IVh (EMRSA-15), the most prevalent in British hospitals, was almost nonexistent in centers of the Iberian Peninsula in that period. These three clones were also predominant in the others Majorcan hospitals. In 2008, 7% of MRSA isolates were PVL-producers. MRSA carriage in participants living in the geriatric facility was 8%, lower in comparison with other studies, and generally intermittent. Previous hospital admission, vascular disease, diabetes mellitus, presence of decubitus ulcers and previous antibiotic treatment were the risk factors for MRSA colonization. Most of the residents carrying MRSA did not develop subsequent MRSA infections. MRSA isolates belonged to two different clones, both found also in the reference hospital. A multidrug resistance conjugative plasmid was described for the first time carriyng cfr, ant(4’)-Ia, tet(L) and dfrK genes driving resistance to linezolid and other antimicrobials in S. aureus and S. epidermidis strains. All the linezolid-resistant S. hominis strains belonged to the same clone and presented the G2576T mutation at the 23S rRNA gene.

Published
2015

15. Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalisEndocarditis in the GAMES Cohort (2008–2017)

Author

Pericàs, Juan M., Ambrosioni, Juan, Muñoz, Patricia, de Alarcón, Arístides, Kestler, Martha, Mari-Hualde, Amaia, Moreno, Asunción, Goenaga, Miguel Á., Fariñas, M. Carmen, Rodríguez-Álvarez, Regino, Ojeda-Burgos, Guillermo, Gálvez-Acebal, Juan, Hidalgo-Tenorio, Carmen, Noureddine, Mariam, Miró, José M., Sánchez, Fernando Fernández, Noureddine, Mariam, Rosas, Gabriel, Lima, Javier de la Torre, Blanco, Roberto, Boado, María Victoria, Lázaro, Marta Campaña, Crespo, Alejandro, Goikoetxea, Josune, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, López, Ma Victoria García, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Cuende, Ana María, Echeverría, Tomás, Fuerte, Ana, Gaminde, Eduardo, Goenaga, Miguel Ángel, Idígoras, Pedro, Iribarren, José Antonio, Yarza, Alberto Izaguirre, Urkola, Xabier Kortajarena, Reviejo, Carlos, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Álvarez, Nemesio, Bravo-Ferrer, José María, Castelo, Laura, Cuenca, José, Llinares, Pedro, Rey, Enrique Miguez, Mayo, María Rodríguez, Sánchez, Efrén, Regueiro, Dolores Sousa, Martínez, Francisco Javier, del Mar Alonso, Ma, Castro, Beatriz, Rosado, Dácil García, del Carmen Durán, Ma, Gómez, Ma Antonia Miguel, Lacalzada, Juan, Nassar, Ibrahim, Ciezar, Antonio Plata, Iglesias, José Ma Reguera, Álvarez, Víctor Asensi, Costas, Carlos, Hera, Jesús de la, Suárez, Jonnathan Fernández, Fraile, Lisardo Iglesias, Arguero, Víctor León, Menéndez, José López, Bajo, Pilar Mencia, Morales, Carlos, Torrico, Alfonso Moreno, Palomo, Carmen, Martínez, Begoña Paya, Esteban, Ángeles Rodríguez, García, Raquel Rodríguez, Asensio, Mauricio Telenti, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Falces, Carlos, Fita, Guillermina, Fuster, David, García de la Mària, Cristina, García-Pares, Delia, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Bermejo, Javier, Bouza, Emilio, Celemín, Daniel, Caballero, Gregorio Cuerpo, Montero, Antonia Delgado, Mansilla, Ana García, Leoni, Ma Eugenia García, Ramallo, Víctor González, Hernández, Martha Kestler, Hualde, Amaia Mari, Marín, Mercedes, Martínez-Sellés, Manuel, Muñoz, Patricia, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Pinilla, Blanca, Pinto, Ángel, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, Antorrena, Isabel, Loeches, Belén, Quirós, Alejandro Martín, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Saldaña, Araceli, Balbín, Jesús Agüero, Castillo, Carlos Armiñanzas, Arnaiz, Ana, de las Revillas, Francisco Arnaiz, Belaustegui, Manuel Cobo, Fariñas, María Carmen, Fariñas-Álvarez, Concepción, Izquierdo, Rubén Gómez, García, Iván, Rico, Claudia González, Gutiérrez-Cuadra, Manuel, Díez, José Gutiérrez, Pajarón, Marcos, Parra, José Antonio, Teira, Ramón, Zarauza, Jesús, Calderón Parra, Jorge, Cobo, Marta, Domínguez, Fernando, Fortaleza, Alberto, Pavía, Pablo García, González, Jesús, Cruz, Ana Fernández, Múñez, Elena, Ramos, Antonio, Romero, Isabel Sánchez, Centella, Tomasa, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, Río, Alejandro del, Rodríguez-Roda Stuart, Jorge, Ruiz, Soledad, Tenorio, Carmen Hidalgo, Delia, Manuel Almendro, Araji, Omar, Barquero, José Miguel, Jambrina, Román Calvo, de Cueto, Marina, Acebal, Juan Gálvez, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, García, Emilio, Haro, Juan Luis, Lepe, José Antonio, López, Francisco, Luque, Rafael, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, Villegas, Antonio Cabrera, García-Álvarez, Lara, Oteo, José Antonio, Sanz, Mercedes, de Benito, Natividad, Gurguí, Mercé, Pacho, Cristina, Pericas, Roser, Pons, Guillem, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Blasco, Andrés Canut, Mollar, José Cordo, Gainzarain Arana, Juan Carlos, Uriarte, Oscar García, López, Alejandro Martín, Ortiz de Zárate, Zuriñe, Urturi Matos, José Antonio, Gloria, García-Domínguez, Antonio, Sánchez-Porto, Leal, José Ma Arribas, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, Valenzuela, Gonzalo de la Morena, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Rodríguez, Anai Moreno, Tarabini-Castellani, Paola, Gálvez, Eva Heredero, Bellido, Carolina Maicas, Pau, José Largo, Sepúlveda, Ma Antonia, Sierra, Pilar Toledano, Iqbal-Mirza, Sadaf Zafar, Alcolea, Eva Cascales, Yañez, Ivan Keituqwa, Martínez, Julián Navarro, Ballesta, Ana Peláez, Escobar, Eduardo Moreno, Monje, Alejandro Peña, Cabrera, Valme Sánchez, García, David Vinuesa, Asenjo, María Arrizabalaga, Luna, Carmen Cifuentes, Morcillo, Juana Núñez, Seco, Ma Cruz Pérez, Gelabert, Aroa Villoslada, Guallar, Carmen Aured, Abad, Nuria Fernández, Mangas, Pilar García, Adell, Marta Matamala, Ruiz, Ma Pilar Palacián, Porres, Juan Carlos, Vidal, Begoña Alcaraz, Trigueros, Nazaret Cobos, Del Amor Espín, María Jesús, Giner Caro, José Antonio, Sánchez, Roberto Jiménez, Almazán, Amaya Jimeno, Freire, Alejandro Ortín, González, Monserrat Viqueira, Ramis, Pere Pericás, Blanco, Ma Ángels Ribas, Ruiz de Gopegui Bordes, Enrique, Bonet, Laura Vidal, Munera, Ma Carmen Bellón, Garaizabal, Elena Escribano, Martínez, Antonia Tercero, Segura Luque, Juan Carlos, Badía, Cristina, Palop, Lucía Boix, Xercavins, Mariona, Eloy Gómez Nebreda, Sónia Ibars., Herrera, Ibalia Horcajada, Gallego Héctor Marrero Santiago, Irene Menduiña, de Miguel Martínez, Isabel, and Álamo, Elena Pisos

Abstract

To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalisinfective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection.

Published
2021
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16. Neurocisticercosis: una enfermedad emergente

Author

Peñaranda Vera, María, Leyes García, María, Ruiz de Gopegui Bordes, Enrique, Ribas Del Blanco, Mª Àngels, Mas Bonet, Antoni, Miralbés Celma, Salvador, Serra Farell, Teresa, Peñaranda Vera, María, Leyes García, María, Ruiz de Gopegui Bordes, Enrique, Ribas Del Blanco, Mª Àngels, Mas Bonet, Antoni, Miralbés Celma, Salvador, and Serra Farell, Teresa

Published
2003

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