373 results on '"Ruiz MC"'
Search Results
2. Multi-year regional infrasound detection of Tungurahua, El Reventador, and Sangay volcanoes in Ecuador from 2006 to 2013
- Author
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Ortiz, HD, Matoza, RS, Garapaty, C, Rose, K, Ramón, P, and Ruiz, MC
- Abstract
As part of the Acoustic Surveillance for Hazardous Eruptions project, two infrasound arrays were installed in northern and central Ecuador. The RIOE and LITE arrays were operational between 2006 and 2013, recording thousands of infrasound signals originating from eruptions of Tungurahua, El Reventador, and Sangay. We use Progressive Multi-Channel Correlation array processing together with hierarchical clustering to identify and associate impulsive infrasound signals with each volcano. Infrasound detections correspond to quasi-continuous activity of Sangay between mid 2006 and mid 2012, at least thirteen periods of activity of Tungurahua between 2006 and mid 2012, and strong signals from El Reventador in early 2008. We validate our detections using satellite observations from the MODIS (Moderate Resolution Imaging Spectroradiometer) volcano detection algorithm (MODVOLC) and independent eruption catalogs. For Sangay, we find a good agreement between our infrasound detections and MODVOLC triggers, whereas for El Reventador the agreement is fair. We attribute the fair correspondence at El Reventador to the low-temporal resolution of MODIS data and frequent cloud cover in the region that reduce satellite observational capability. Finally, our study highlights the benefits of infrasound arrays for monitoring volcanoes in Ecuador at regional distances, while further investigating the processes that limit volcanic infrasound detection.
- Published
- 2020
3. Digital tumor in a woman with metastatic melanoma
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Moneva-Leniz LM, Garrido-Ruiz MC, and Rodriguez-Peralto JL
- Published
- 2020
4. Tuberculosis incidence among infected contacts detected through contact tracing of smear-positive patients
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Martin-Sanchez, M, Brugueras, S, de Andres, A, Simon, P, Gorrindo, P, Ros, M, Masdeu, E, Millet, JP, Cayla, JA, Orcau, A, Ospina, J, Rafi, T, Abdelkarim, S, Lin, XM, Burcea, I, Diatta, O, Clos, R, Santoma, MJ, Badosa, I, Rovira, G, Martinez, JA, Ligero, C, Vilella, A, Pomar, V, Fontanet, A, Molina, I, Salvador, F, Sanchez-Montalva, A, Saborit, N, Rodrigo, JA, Martinez, X, Jimenez, MA, Mila, C, Solsona, J, de Souza, ML, Cantos, A, Knobel, H, Jove, N, Sanchez, F, Gracia, XC, Ruiz, MC, and Rius, C
- Abstract
Background The contacts of people with pulmonary tuberculosis (PTB) have a high risk of becoming infected and developing tuberculosis (TB). Our aim was to determine the incidence of TB and its risk factors in a cohort of contacts with latent TB infection (LTBI) detected through contact tracing of smear-positive PTB cases. Methods and findings We performed a population-based retrospective cohort study including contacts that had LTBI, and were contacts of people with PTB who started treatment between 2008 and 2014. We followed up contacts until they developed TB or until the end date for follow-up (31st December 2016). We used Kaplan-Meier curves to compute incidence at 2 and 5 years, and Cox regression to compute hazard ratios (HR) and their 95% confidence intervals (CI). We analyzed 3097 close contacts of 565 PTB cases. After exclusion of 81 coprevalent TB cases, 953 contacts had LTBI, of which 14 developed TB. Their risk of developing TB after two and five years was 0.7% (CI: 0.3-1.6) and 1.8% (CI: 1.1-3.1) respectively. Contacts who had not been referred for LTBI treatment had a 1.0% (CI: 0.24.0) risk at 5 years. Risk of developing TB at 5 years was 1.2% (CI: 0.5-3.0) among people who completed treatment, and 11.1% (CI: 5.1-23.3) for those who did not. Risk factors for TB were not completing LTBI treatment (HR 9.4, CI: 2.9-30.8) and being female (HR 3.5, CI: 1.1-11-3). Conclusions LTBI treatment plays a fundamental role in decreasing the risk of developing TB. It is necessary to achieve a maximum contact tracing coverage and the highest possible compliance with LTBI treatment.
- Published
- 2019
5. Understanding cyclic seismicity and ground deformation patterns at volcanoes: intriguing lessons from Tungurahua volcano, Ecuador
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Neuberg, JW, Collinson, ASD, Mothes, PA, Ruiz, MC, Aguaiza, S, and Mather, TA
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Physics::Geophysics - Abstract
Cyclic seismicity and ground deformation patterns are observed on many volcanoes worldwide where seismic swarms and the tilt of the volcanic flanks provide sensitive tools to assess the state of volcanic activity. Ground deformation at active volcanoes is often interpreted as pressure changes in a magmatic reservoir, and tilt is simply translated accordingly into inflation and deflation of such a reservoir. Tilt data recorded by an instrument in the summit area of Tungurahua volcano in Ecuador, however, show an intriguing and unexpected behaviour on several occasions: prior to a Vulcanian explosion when a pressurisation of the system would be expected, the tilt signal declines significantly, hence indicating depressurisation. At the same time, seismicity increases drastically. Envisaging that such a pattern could carry the potential to forecast Vulcanian explosions on Tungurahua, we use numerical modelling and reproduce the observed tilt patterns in both space and time. We demonstrate that the tilt signal can be more easily explained as caused by shear stress due to viscous flow resistance, rather than by pressurization of the magmatic plumbing system. In general, our numerical models prove that if magma shear viscosity and ascent rate are high enough, the resulting shear stress is sufficient to generate a tilt signal as observed on Tungurahua. Furthermore, we address the interdependence of tilt and seismicity through shear stress partitioning and suggest that a joint interpretation of tilt and seismicity can shed new light on the eruption potential of silicic volcanoes.
- Published
- 2018
6. Exposure to ambient particulate matter induces oxidative stress in lung and aorta in a size- and time-dependent manner in rats
- Author
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Aztatzi-Aguilar, OG, primary, Valdés-Arzate, A, additional, Debray-García, Y, additional, Calderón-Aranda, ES, additional, Uribe-Ramirez, M, additional, Acosta-Saavedra, L, additional, Gonsebatt, ME, additional, Maciel-Ruiz, JA, additional, Petrosyan, P, additional, Mugica-Alvarez, V, additional, Gutiérrez-Ruiz, MC, additional, Gómez-Quiroz, LE, additional, Osornio-Vargas, A, additional, Froines, J, additional, Kleinman, MT, additional, and De Vizcaya-Ruiz, A, additional
- Published
- 2018
- Full Text
- View/download PDF
7. Management of Temporo-Mandibular Disorders in children and adolescents: A literature review
- Author
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Rosales ME, Miguel, Garrocho DC, José, Ruiz MC, María, Márquez, Raúl, Pozos PhD, Amaury, Rosales ME, Miguel, Garrocho DC, José, Ruiz MC, María, Márquez, Raúl, and Pozos PhD, Amaury
- Abstract
The purpose of this review is to provide the fundamental information for the early diagnosis of temporomandibular disorders (TMD) in children and adolescents, taking in account that the general trend among Dentists is to believe that these kind of disorders do not occur in the pediatric patient, or that they are present very rarely. However, this is not true; therefore, it is mandatory that, during the comprehensive clinical exam of the pediatric patient, a meticulous evaluation of the developing temporomandibular joint is included. The present paper pretends to serve as encourage interested to general and specialist Dentists on this important issue, and capable to advise, guide or treat their own patients, particularly young children; these patients cannot often communicate sufficiently their symptoms, because of their immaturity. Thus, only through a full exam, temporomandibular disturbances can be properly assessed, diagnosed and treated.
- Published
- 2016
8. Management of Temporo-Mandibular Disorders in children and adolescents: A literature review
- Author
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Rosales ME, Miguel, primary, Garrocho DC, José, additional, Ruiz MC, María, additional, Márquez MC, Raúl, additional, and Pozos DC, Amaury, additional
- Published
- 2016
- Full Text
- View/download PDF
9. Management of Temporo-Mandibular Disorders in children and adolescents: A literature review
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Raúl Márquez Mc, María Ruiz Mc, Miguel Rosales Me, Amaury de J. Pozos, and José Garrocho Dc
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Mixed ,medicine.medical_specialty ,Pediatric dentistry ,Adolescent ,Mandibular Disorders ,Dentition ,business.industry ,Clinical exam ,Temporomandibular joint ,Temporomandibular joint dysfunction syndrome ,stomatognathic diseases ,Pediatric patient ,medicine.anatomical_structure ,medicine ,Physical therapy ,Temporomandibular Joint Dysfunction Syndrome ,Child ,business - Abstract
The purpose of this review is to provide the fundamental information for the early diagnosis of temporomandibular disorders (TMD) in children and adolescents, taking in account that the general trend among Dentists is to believe that these kind of disorders do not occur in the pediatric patient, or that they are present very rarely. However, this is not true; therefore, it is mandatory that, during the comprehensive clinical exam of the pediatric patient, a meticulous evaluation of the developing temporomandibular joint is included. The present paper pretends to serve as encourage interested to general and specialist Dentists on this important issue, and capable to advise, guide or treat their own patients, particularly young children; these patients cannot often communicate sufficiently their symptoms, because of their immaturity. Thus, only through a full exam, temporomandibular disturbances can be properly assessed, diagnosed and treated.
- Published
- 2016
- Full Text
- View/download PDF
10. Studies on the mechanisms of tumour inhibition by fractions from two species of Cat's Claw
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Urdanibia, I, primary, Ibarra, C, additional, Michelangeli, F, additional, Ruiz, MC, additional, Milano, B, additional, and Taylor, P, additional
- Published
- 2014
- Full Text
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11. Screening of Venezuelan medicinal plant extracts for cytostatic and cytotoxic activity against tumour cell lines
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Taylor, P, primary, Arsenak, M, additional, Abad, MJ, additional, Fernández, Á, additional, Gonto, R, additional, Ruiz, MC, additional, Fraile, S, additional, Taylor, S, additional, and Michelangeli, OEF, additional
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- 2012
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12. Anti-inflammatory effects of Byrsonima crassifolia
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García, M, primary, Villamizar, JE, additional, Salazar, F, additional, Ibarra, C, additional, Michelangeli, F, additional, Ruiz, MC, additional, and Taylor, P, additional
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- 2012
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13. Anti-inflammatory effects of different preparations of cat's claw
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Urdanibia, I, primary, Estrada, O, additional, Ibarra, C, additional, Michelangeli, F, additional, Ruiz, MC, additional, and Taylor, P, additional
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- 2012
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14. Study of the anti-inflammatory and antitumour effects of a hydroethanolic extract of the plant Piper marginatum
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Contreras, A, primary, Villasmil, J, additional, Abad, MJ, additional, Arsenak, M, additional, Michelangeli, F, additional, Fernández, A, additional, Ruiz, MC, additional, Fraile, S, additional, and Taylor, P, additional
- Published
- 2009
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15. The effect of chronic and acute ethanol treatment on morphology, lipid peroxidation, enzyme activities and Na+ transport systems on WRL-68 cells
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Gutiérrez-Ruiz, MC, primary, Bucio, L., additional, Souza, V., additional, and Cárabez, A., additional
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- 1995
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16. On preservation of some,shifted and proportional orders by systems
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Belzunce, H., José Ruiz, and Ruiz, Mc
17. On closure of the IFR(2) and NBU(2) classes
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Franco, M., José Ruiz, and Ruiz, Mc
18. Images in clinical medicine. Unfortunate ingestion.
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Ruiz MC, Soler-Gonzalez J, Ruiz, M C, and Soler-Gonzalez, J
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- 2005
19. Images in clinical medicine. Mondor's disease.
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Soler-González J and Ruiz MC
- Published
- 2005
20. School-based hepatitis B immunization program in adolescents.
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Kershenobich D, Gutierrez-Ruiz MC, Olivera-Martínez MA, Santos I, Cortina-De la Fuente D, Fuentes-Ugalde AP, Pérez-Pruna CA, Gonzalez Teissier J, Ficachi M, and Ariza Cañadilla A
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- 2002
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21. Prevenció i actuació davant el risc de caigudes en pediatria a l’àmbit hospitalari
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[Agustín C, Troyano, MJ] Hospital Universitari Maternoinfantil Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. [Bringué J] Hospital Comarcal del Pallars, Tremp, Lleida, Spain. [Gargallo E, Ortiz I] Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Jiménez-Ordoñez M] Servei de Promoció de la Qualitat i la Bioètica, Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Planella M] Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut, Girona, Spain. [Pujol M] Hospital de la Sant Creu i Sant Pau, Barcelona, Spain. [Ruiz MC] Consorci Sanitari del Maresme, Mataró, Spain. [Sagrera C] Hospital Universitari General de Catalunya, Quironsalud, Sant Cugat del Vallès, Spain. [Tapia V] Hospital Universitari Arnau de Vilanova, Lleida, Spain and Departament de Salut
- Subjects
Other subheadings::Other subheadings::/prevention & control [Other subheadings] ,Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores] ,Pediatria ,Empleos en Salud::Medicina::Pediatría [DISCIPLINAS Y OCUPACIONES] ,Environment and Public Health::Public Health::Accidents::Accidental Falls [HEALTH CARE] ,Health Occupations::Medicine::Pediatrics [DISCIPLINES AND OCCUPATIONS] ,Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals::Hospitals, Special::Hospitals, Pediatric [HEALTH CARE] ,ambiente y salud pública::salud pública::accidentes::caídas accidentales [ATENCIÓN DE SALUD] ,Caigudes (Accidents) - Prevenció ,Hospitals infantils - Catalunya ,Instalaciones para Atención de Salud, Recursos Humanos y Servicios::Instituciones de Salud::Hospitales::Hospitales Especializados::Hospitales Pediátricos [ATENCIÓN DE SALUD] - Published
- 2021
22. Prevenció i actuació davant del risc de caigudes a l’àrea maternal i neonatal
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Agustín, Concepció, Bringué, Judith, Gargallo, Estrella, Jiménez-Ordoñez, Marisa, Ortiz, Irene, Planella, Montserrat, Pujol, Montserrat, Ruiz, Maria C., Sagrera, Cristina, Tapia, Violeta, Troyano, Maria J., [Agustín C, Troyano, MJ] Hospital Universitari Maternoinfantil Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. [Bringué J] Hospital Comarcal del Pallars, Tremp, Lleida, Spain. [Gargallo E, Ortiz I] Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Jiménez-Ordoñez M] Servei de Promoció de la Qualitat i la Bioètica, Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Planella M] Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut, Girona, Spain. [Pujol M] Hospital de la Sant Creu i Sant Pau, Barcelona, Spain. [Ruiz MC] Consorci Sanitari del Maresme, Mataró, Spain. [Sagrera C] Hospital Universitari General de Catalunya, Quironsalud, Sant Cugat del Vallès, Spain. [Tapia V] Hospital Universitari Arnau de Vilanova, Lleida, Spain, and Departament de Salut
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Other subheadings::Other subheadings::/prevention & control [Other subheadings] ,Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores] ,Environment and Public Health::Public Health::Accidents::Accidental Falls [HEALTH CARE] ,ambiente y salud pública::salud pública::accidentes::caídas accidentales [ATENCIÓN DE SALUD] ,Caigudes (Accidents) - Prevenció ,Health Occupations::Medicine::Pediatrics::Neonatology [DISCIPLINES AND OCCUPATIONS] ,profesiones sanitarias::medicina::pediatría::neonatología [DISCIPLINAS Y OCUPACIONES] ,Neonatologia - Abstract
Risc de caigudes; Prevenció; Àrea maternal Riesgo de caídas; Prevención; Área maternal Risk of falls; Prevention; Maternal area En aquest article es presenta part del treball realitzat pel Grup de treball de caigudes amb l’objectiu de proporcionar recomanacions per prevenir caigudes tant en els nadons sans a terme com en els nadons que es troben en una situació de vulnerabilitat, des del moment del naixement i durant tota l’estada hospitalària.
- Published
- 2019
23. Prevenció i actuació davant el risc de caigudes en pediatria a l’àmbit hospitalari
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Agustín, Concepció, Bringué, Judith, Gargallo, Estrella, Jiménez-Ordoñez, Marisa, Ortiz, Irene, Planella, Montserrat, Pujol, Montserrat, Ruiz, Maria C., Sagrera, Cristina, Tapia, Violeta, Troyano, Maria J., [Agustín C, Troyano, MJ] Hospital Universitari Maternoinfantil Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain. [Bringué J] Hospital Comarcal del Pallars, Tremp, Lleida, Spain. [Gargallo E, Ortiz I] Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Jiménez-Ordoñez M] Servei de Promoció de la Qualitat i la Bioètica, Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Planella M] Hospital Universitari de Girona Doctor Josep Trueta, Institut Català de la Salut, Girona, Spain. [Pujol M] Hospital de la Sant Creu i Sant Pau, Barcelona, Spain. [Ruiz MC] Consorci Sanitari del Maresme, Mataró, Spain. [Sagrera C] Hospital Universitari General de Catalunya, Quironsalud, Sant Cugat del Vallès, Spain. [Tapia V] Hospital Universitari Arnau de Vilanova, Lleida, Spain, and Departament de Salut
- Subjects
Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores] ,Empleos en Salud::Medicina::Pediatría [DISCIPLINAS Y OCUPACIONES] ,Pediatria ,instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::hospitales::hospitales especializados::hospitales pediátricos [ATENCIÓN DE SALUD] ,Environment and Public Health::Public Health::Accidents::Accidental Falls [HEALTH CARE] ,Health Occupations::Medicine::Pediatrics [DISCIPLINES AND OCCUPATIONS] ,Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals::Hospitals, Special::Hospitals, Pediatric [HEALTH CARE] ,ambiente y salud pública::salud pública::accidentes::caídas accidentales [ATENCIÓN DE SALUD] ,Medio Ambiente y Salud Pública::Salud Pública::Accidentes::Accidentes por Caídas [ATENCIÓN DE SALUD] ,Other subheadings::Other subheadings::/prevention & control [Other subheadings] ,Caigudes (Accidents) - Prevenció ,Hospitals infantils - Catalunya ,profesiones sanitarias::medicina::pediatría [DISCIPLINAS Y OCUPACIONES] ,Instalaciones para Atención de Salud, Recursos Humanos y Servicios::Instituciones de Salud::Hospitales::Hospitales Especializados::Hospitales Pediátricos [ATENCIÓN DE SALUD] - Abstract
Risk of falls; Prevention; Hospital paediatrics Riesgo de caidas; Prevención; Pediatria hospitalaria Risc de caigudes; Prevenció; Pediatria hospitalària El setembre de 2015 es va crear un Grup de treball de caigudes, format per infermers experts en les àrees maternal, neonatal, pediàtrica i de seguretat del pacient de diferents centres hospitalaris de Catalunya. En aquest article es presenta part del treball realitzat per aquest grup amb els següents objectius: 1) conèixer la prevalença del risc de caigudes a l’àmbit hospitalari pediàtric en els hospitals de Catalunya i 2) realitzar recomanacions per reduir les caigudes en pacients ingressats en les unitats de pediatria dels hospitals de Catalunya. In September 2015, a Falling Work Group was formed, consisting of expert nurses in the maternal, neonatal, pediatric and patient health areas of different hospitals in Catalonia. This article presents part of the work carried out by this group with the following objectives: 1) to know the prevalence of the risk of falls in the pediatric hospital setting in the hospitals of Catalonia and 2) to make recommendations to reduce the falls in patients admitted to pediatric units of hospitals in Catalonia. En septiembre de 2015 se creó un Grupo de trabajo de caídas, formado por enfermeros expertos en las áreas maternal, neonatal, pediátrica y de seguridad del paciente de diferentes centros hospitalarios de Cataluña. En este artículo se presenta parte del trabajo realizado por este grupo con los siguientes objetivos: 1) conocer la prevalencia del riesgo de caídas en el ámbito hospitalario pediátrico en los hospitales de Cataluña y 2) realizar recomendaciones para reducir las caídas en pacientes ingresados en las unidades de pediatría de los hospitales de Cataluña.
- Published
- 2018
24. Osteoporosis e índice de masa corporal en el trasplantado renal
- Author
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López Ruiz,María del Carmen, Ortega Martínez,Ana Raquel, Fernández Castillo,Rafael, Esteban de la Rosa,Rafael José, Bravo Soto,Juan Antonio, [López Ruiz,MC] Departamento de Ciencias de la Salud, Universidad de Jaén, Jaén, España. [Ortega Martínez,AR] Departamento de Psicología, Universidad de Jaén, Jaén, España. [Fernández Castillo,R] Departamento de Enfermería, Universidad de Granada, Granada, España. [Esteban de la Rosa,RJ, and Bravo Soto,JA] Servicio de Nefrología, Hospital Universitario Virgen de las Nieves, Granada, España.
- Subjects
Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] ,Obesidad ,Renal transplantation ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings] ,Índice de masa corporal ,Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Metabolic::Osteoporosis [Medical Subject Headings] ,Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings] ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Trasplante renal ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Organ Transplantation::Kidney Transplantation [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies [Medical Subject Headings] ,Osteoporosis ,Obesity ,Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings] ,Body mass index - Abstract
Introducción y objetivos: tras el trasplante renal es frecuente un aumento de peso, así como un elevado porcentaje de obesidad en estos pacientes. Por otro lado, tras el trasplante se produce una pérdida de la masa ósea, siendo la prevalencia de osteoporosis y fracturas óseas mayor que en la población general. Objetivos: explorar la relación entre el índice de masa corporal y la prevalencia de osteopenia y osteoporosis en una población de trasplantados renales. Material y método: estudio longitudinal prospectivo sobre una muestra de 306 trasplantados renales. Se exploraron las relaciones entre el peso y el índice de masa corporal con la prevalencia de osteopenia y osteoporosis a nivel femoral y lumbar en el momento del trasplante y a los 12 meses del mismo. Resultados: se halló una alta prevalencia de sobrepeso (35,6%) y obesidad (14,1%) tras el trasplante renal y al año del mismo (42,2% y 24,2%, respectivamente). Se hallaron diferencias estadísticamente significativas (p = 0,049) entre el peso en el momento del trasplante y la presencia de osteopenia u osteoporosis al año del mismo a nivel lumbar, siendo el peso medio más elevado entre los pacientes con osteoporosis. La media del IMC fue más elevada (p = 0,028) en los pacientes osteoporóticos (26,59 kg/m2) que en los pacientes con osteopenia (24,23 kg/m2). Conclusiones: nuestros resultados parecen estar en concordancia con recientes estudios realizados en la población general, que muestran el sobrepeso como un posible factor perjudicial para el hueso. Introduction: frequently after kidney transplantation there is an increase in weight with a resulting high percent of obesity in these recipients. This combined with a rapid loss of bone mass, a higher prevalence of osteoporosis and fractures is evident than in normal populations. Objectives: to explore the relationship between body mass index (BMI) and prevalence of osteoporosis in a population of renal transplant recipients. Methods: prospective longitudinal study design. The study was conducted on 306 kidney transplant recipients. The relationship between weigh and body mass index with femoral and lumbar osteopenia and osteoporosis prevalence at the moment of transplant and at 12 months post was explored. Results: there was a high prevalence of overweight (35.6%) and obese (14.1%) recipients after renal transplant and 1 year after (42.2% and 24.2% respectively). Significant differences were found(p = 0.049) between the weight at the time of transplant and the presence of osteopenia or osteoporosis at the lumbar level one year after, the highest weights were in recipients with osteoporosis. The mean BMI was higher (p = 0.028) in osteoporotic patients (26.59 kg/m2) than in patients with osteopenia (24.23 kg/m2). Conclusion: results seem to be consistent with recent studies in the general population showing excessive weight as a possible factor detrimental to the bone health.
- Published
- 2015
25. Combinative effects of thinning and prescribed burning on fuel reduction and soil arthropods: A case study in a Mediterranean pine forest.
- Author
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Longeard P, Santonja M, Morandini F, Gibernau M, Nadarajah S, Belliard P, Feignier N, Massaiu A, Andrei-Ruiz MC, and Ferrat L
- Abstract
Wildfire pressure involves today to implement silvicultural practices that provide a good compromise between reducing fire risk and maintaining ecological functioning. Thinning reduces tree density and low branches, but results in the deposition of a considerable biomass of woody debris on the ground (up to 4800 g m
2 in this study). They can be eliminated by prescribed burning, but this raises questions about the fire intensity that can be generated and the impact on soil fauna. We undertook the monitoring of a thinning and prescribed burning operation, separated and combined, in November 2020, in a Pinus laricio stand prone to fire risk, located in Bavella, Corsica. Fuel load was determined, and temperature measurements in the soil were performed using K-type thermocouples. Soil arthropod populations were monitored using pitfall traps, in particular Collembola, Acari, Aranae, and Coleoptera. The combination of thinning and burning resulted in a fire intensity of 75.8 versus 8.4 kW m-1 for burning alone. Maximum temperature rise measured at -2 cm below the surface was less than 5°C for both treatments. The combination of thinning and burning did not result in higher fire intensity at ground level than burning alone, and the soil showed high insulation capacity. Most of the woody debris that burned was small-diameter, and large-diameter debris remained unconsumed. This burning, performed during a period of low biological activity, had no effect on soil arthropods, and the presence of large debris may have provided refuge areas. Collembola group was the faster to recover, and were followed by cohorts of predators in summer, especially Acari. Our results suggest that a combination of burning and thinning in autumn may be beneficial for fire prevention. However, the decomposition of woody debris in relation to fire risk, and the occurrence of pests after these treatments need to be monitored., Competing Interests: The authors declare that they have no conflict of interest., (© 2024 The Author(s). Ecology and Evolution published by John Wiley & Sons Ltd.)- Published
- 2024
- Full Text
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26. The ecto-enzyme CD38 modulates CD4T cell immunometabolic responses and participates in HIV pathogenesis.
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Díaz-Basilio F, Vergara-Mendoza M, Romero-Rodríguez J, Hernández-Rizo S, Escobedo-Calvario A, Fuentes-Romero LL, Pérez-Patrigeon S, Murakami-Ogasawara A, Gomez-Palacio M, Reyes-Terán G, Jiang W, Vázquez-Pérez JA, Marín-Hernández Á, Romero-Rodríguez DP, Gutiérrez-Ruiz MC, Viveros-Rogel M, and Espinosa E
- Subjects
- Humans, Jurkat Cells, Receptors, Antigen, T-Cell metabolism, Receptors, Antigen, T-Cell immunology, Membrane Glycoproteins metabolism, Glycolysis, Mitochondria metabolism, ADP-ribosyl Cyclase 1 metabolism, HIV Infections immunology, HIV Infections pathology, CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes metabolism
- Abstract
Despite abundant evidence correlating T cell CD38 expression and HIV infection pathogenesis, its role as a CD4T cell immunometabolic regulator remains unclear. We find that CD38's extracellular glycohydrolase activity restricts metabolic reprogramming after T cell receptor (TCR)-engaging stimulation in Jurkat T CD4 cells, together with functional responses, while reducing intracellular nicotinamide adenine dinucleotide and nicotinamide mononucleotide concentrations. Selective elimination of CD38's ectoenzyme function licenses them to decrease the oxygen consumption rate/extracellular acidification rate ratio upon TCR signaling and to increase cycling, proliferation, survival, and CD40L induction. Pharmacological inhibition of ecto-CD38 catalytic activity in TM cells from chronic HIV-infected patients rescued TCR-triggered responses, including differentiation and effector functions, while reverting abnormally increased basal glycolysis, cycling, and spontaneous proinflammatory cytokine production. Additionally, ecto-CD38 blockage normalized basal and TCR-induced mitochondrial morphofunctionality, while increasing respiratory capacity in cells from HIV+ patients and healthy individuals. Ectoenzyme CD38's immunometabolic restriction of TCR-involving stimulation is relevant to CD4T cell biology and to the deleterious effects of CD38 overexpression in HIV disease., Competing Interests: Conflict of interest statement. E.E. is the inventor of a submitted patent application by the National Institute of Respiratory Diseases Ismael Cosío Villegas covering CD38 ectoenzymatic inhibition (Instituto Mexicano de la Propiedad Industrial, 26 September 2018, application number MX/E/2018/072036)., (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
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- 2024
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27. Health inequalities and their relationship with socioeconomic indicators in the Maresme region (Catalonia): A cross-sectional ecological study.
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Ruiz MC, Serra-Prat M, Palomera E, Yildirim M, and Valls J
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- Humans, Cross-Sectional Studies, Male, Female, Middle Aged, Spain epidemiology, Aged, Adult, Hospitalization statistics & numerical data, Health Status Disparities, Socioeconomic Factors
- Abstract
Objective: Health inequalities are universal, but their magnitude and determinants vary according to geographic areas, and understanding variations is essential to designing and implementing preventive and corrective policies. Our objective was to evaluate health inequalities in the Maresme region (Catalonia, Spain) and the relationship with socioeconomic indicators., Design: Cross-sectional ecological study (2017). SITE: Maresme region., Participants: Population assigned to any of the Maresme's 21 basic health areas (BHAs)., Measures: Sociodemographic, socioeconomic, health, and health resource use indicators published by the Catalan Health Service's Information and Knowledge Unit., Results: Differences observed between BHAs were 49% in mortality, 266% in diabetes incidence, 348% in stroke incidence, and 89% in hospitalizations. In the most compared to the least disadvantaged BHAs, socioeconomic deprivation, as measured by the socioeconomic index (SEI), was 4.6 times greater and the percentage population with low educational attainment (EA) was 3.7 times higher. Greater deprivation was associated with greater prevalence of diabetes, chronic obstructive pulmonary disease, and high blood pressure, and greater incidence of diabetes, ischemic heart disease, and cancer. Likewise, a greater percentage population with low EA was associated with higher premature mortality and avoidable hospitalizations., Conclusion: Great variation exists in socioeconomic, health, and health resource use between the different Maresme BHAs. Socioeconomic deprivation is strongly correlated with the prevalence and incidence of certain chronic diseases, and low EA is correlated with premature mortality and avoidable hospitalizations. Our findings point to the urgency of taking health inequalities into account in designing and implementing healthcare strategies, programs, and policies., (© 2024 The Author(s). Public Health Nursing published by Wiley Periodicals LLC.)
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- 2024
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28. Neurotransmitters and Networks Interplay in Cognition and Gait Disturbances in Patients With Parkinson Disease: Beyond Lesion Localization.
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Merino Ruiz MC and Mortari MR
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- Humans, Cognition physiology, Parkinson Disease complications, Parkinson Disease physiopathology, Gait Disorders, Neurologic etiology, Gait Disorders, Neurologic physiopathology, Neurotransmitter Agents metabolism
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- 2024
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29. Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia.
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Rojas-Torres M, Beltrán-Camacho L, Martínez-Val A, Sánchez-Gomar I, Eslava-Alcón S, Rosal-Vela A, Jiménez-Palomares M, Doiz-Artázcoz E, Martínez-Torija M, Moreno-Luna R, Olsen JV, and Duran-Ruiz MC
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- Animals, Mice, Umbilical Cord cytology, Male, Mesenchymal Stem Cell Transplantation methods, Neovascularization, Physiologic, Endothelial Cells, Humans, Adipose Tissue, Mice, Nude, Mice, Inbred BALB C, Disease Models, Animal, Mesenchymal Stem Cells, Ischemia therapy, Ischemia physiopathology
- Abstract
Background: Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by atherosclerosis. CLTI patients suffer from high risk of amputation of the lower extremities and elevated mortality rates, while they have low options for surgical revascularization due to associated comorbidities. Alternatively, cell-based therapeutic strategies represent an effective and safe approach to promote revascularization. However, the variability seen in several factors such as cell combinations or doses applied, have limited their success in clinical trials, being necessary to reach a consensus regarding the optimal "cellular-cocktail" prior further application into the clinic. To achieve so, it is essential to understand the mechanisms by which these cells exert their regenerative properties. Herein, we have evaluated, for the first time, the regenerative and vasculogenic potential of a combination of endothelial colony forming cells (ECFCs) and mesenchymal stem cells (MSCs) isolated from adipose-tissue (AT), compared with ECFCs from umbilical cord blood (CB-ECFCs) and AT-MSCs, in a murine model of CLTI., Methods: Balb-c nude mice (n:32) were distributed in four different groups (n:8/group): control shams, and ischemic mice (after femoral ligation) that received 50 µl of physiological serum alone or a cellular combination of AT-MSCs with either CB-ECFCs or AT-ECFCs. Follow-up of blood flow reperfusion and ischemic symptoms was carried out for 21 days, when mice were sacrificed to evaluate vascular density formation. Moreover, the long-term molecular changes in response to CLTI and both cell combinations were analyzed in a proteomic quantitative approach., Results: AT-MSCs with either AT- or CB-ECFCs, promoted a significant recovery of blood flow in CLTI mice 21 days post-ischemia. Besides, they modulated the inflammatory and necrotic related processes, although the CB group presented the slowest ischemic progression along the assay. Moreover, many proteins involved in the repairing mechanisms promoted by cell treatments were identified., Conclusions: The combination of AT-MSCs with AT-ECFCs or with CB-ECFCs promoted similar revascularization in CLTI mice, by restoring blood flow levels, together with the modulation of the inflammatory and necrotic processes, and reduction of muscle damage. The protein changes identified are representative of the molecular mechanisms involved in ECFCs and MSCs-induced revascularization (immune response, vascular repair, muscle regeneration, etc.)., (© 2024. The Author(s).)
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- 2024
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30. Small concentrations, big results: μM addition of photoactive iron oxides with PMS, PDS, or H 2 O 2 , leads to enhanced removal of viruses at near-neutral pH.
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Jia J, Minella M, Ruiz MC, Decker J, Li D, Gonçalves NPF, Prevot AB, Lin T, and Giannakis S
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- Hydrogen-Ion Concentration, Water Purification methods, Sulfates chemistry, Peroxides chemistry, Hydrogen Peroxide chemistry, Ferric Compounds chemistry
- Abstract
The photo-Fenton process is effective for pathogen removal, and its low-cost versions can be applied in resource-poor contexts. Herein, a photo-Fenton-like system was proposed using low concentrations of iron oxides (hematite and magnetite) and persulfates (peroxymonosulfate - PMS, and peroxydisulfate - PDS), which exhibited excellent inactivation performance towards MS2 bacteriophages. In the presence of bacteria, MS2 inactivation was inhibited in H
2 O2 and PDS systems but promoted in PMS-involved systems. The inactivation efficacy of all the proposed systems for mixed bacteria and viruses was greater than that of the sole bacteria, showing potential practical applications. The inactivation performance of humic acid-incorporated iron oxides mediating photo-Fenton-like processes was also studied; except for the PMS-involved system, the inactivation efficacy of the H2 O2 - and PDS-involved systems was inhibited, but the PDS-involved system was still acceptable (< 2 h). Reactive species exploration experiments indicated that ·OH was the main radical in the H2 O2 and PDS systems, whereas1 O2 played a key role in the PMS-involved system. In summary, hematite- and magnetite-mediated persulfate-assisted photo-Fenton-like systems at low concentrations can be used as alternatives to the photo-Fenton process for virus inactivation in sunny areas, providing more possibilities for point-of-use drinking water treatment in developing countries., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Ltd.)- Published
- 2024
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31. Responses of underground air and drip water geochemistry to meteorological factors: A multi-parameter approach in the Rull Cave (Spain).
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Ruiz MC, Pla C, Fernandez-Cortes A, and Benavente D
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Our research aims to assess the complex interactions between the elements that constitute and influence a cave system through the analysis of an extensive dataset of climatic and environmental parameters (
222 Rn, CO2 , drip rates, chemical composition, and environmental isotopes) measured in air, water, and solid in the Rull Cave (southeastern Spain). Of particular importance is understanding the effect of rainfall and temperature on water and gas transport through the epikarst and the involved processes. Our results show that the cave gaseous concentration patterns do not only depend on the temperature-caused movement of air masses, but they can also be affected by abundant rainfall. The δ18 O and δD composition of cave water also relies on such precipitations for the effective transfer of the rainfall signal into the cave, which can take between 3 and 7 days. The elemental ratios (Sr/Ca and Mg/Ca) show high responsiveness to the water drip rate, hinting that enhanced prior calcite precipitation (PCP) occurs at slower drip rates. Despite this, and regardless of drip rates, calcite saturation indices follow a seasonal variation pattern inversely proportional to the cave air CO2 concentration, while δ13 C-DIC is proportional. Our results show how the interlinkage between these multiple components defines the dynamics of the atmosphere-soil-cave system. Cave monitoring is then essential to understand the karstic vadose zone, which is highly sensitive to climatic influence and its changes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2024
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32. A Web-Based Physical Activity Promotion Intervention for Inactive Parent-Child Dyads: Protocol for a Randomized Controlled Trial.
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Phipps D, Green WT, Aho R, Kettunen E, Biddle S, Hamilton K, Laukkanen A, Aunola K, Chan DK, Hankonen N, Hassandra M, Kärkkäinen T, Kykyri VL, Polet J, Rhodes R, Ruiz MC, Sääkslahti A, Schneider J, Toivonen HM, Lintunen T, Hagger M, and Knittle K
- Abstract
Background: Low levels of physical activity are associated with numerous adverse health outcomes, yet sedentary lifestyles are common among both children and adults. Physical activity levels tend to decline steeply among children aged between 8 and 12 years, even though children's behavioral patterns are largely governed by familial structures. Similarly, parents' activity levels have been generally reported as lower than those of nonparents of comparable age. For this reason, family-based physical activity promotion interventions are a potentially valuable and relatively underresearched method for mitigating physical activity declines as children develop into adolescents and for increasing physical activity in parents., Objective: This study aims to assess the efficacy, feasibility, and acceptability of a novel theory-based web-based physical activity promotion intervention among parent-child dyads in Finland who do not meet physical activity recommendations at baseline., Methods: Participants (target N=254) will be recruited from the general population using a panel company and advertisements on social media and randomly assigned to either an immediate intervention group or a waitlist control group. The intervention consists of 4 web-based group workshops over the course of 10 weeks, web-based tasks and resources, and a social support chat group. Data on physical activity behavior and constructs from the integrated behavior change model will be collected through self-report surveys assessing physical activity, autonomy support, autonomous motivation, attitude, subjective norm, perceived behavioral control, intention, self-monitoring, habit, and accelerometer measurements at baseline, post intervention, and 3 months post intervention. Exit interviews with participants will assess the feasibility and acceptability of the intervention procedures., Results: This study will reveal whether the intervention changes leisure-time physical activity among intervention participants relative to the control group and will examine the intervention's effects on important theoretical predictors of physical activity. It will also yield data that can be used to refine intervention materials and inform further implementation. Trial recruitment commenced in September 2023, and data collection should be completed by December 2024., Conclusions: The planned intervention has potential implications for both theory and practice. Practically, the use of an entirely web-based intervention may have scalable future uses for improving physical activity in 2 key populations, while also potentially informing on the value of dyadic, family-based strategies for encouraging an active lifestyle as an alternative to strategies that target either parents or children independently. Further, by assessing change in psychological constructs alongside potential change in behavior, the intervention also allows for important tests of theory regarding which constructs are most linked to favorable behavior change outcomes., Trial Registration: ClinicalTrials.gov NCT06070038; https://clinicaltrials.gov/study/NCT06070038., International Registered Report Identifier (irrid): DERR1-10.2196/55960., (©Daniel Phipps, Weldon Thomas Green, Reetta Aho, Eeva Kettunen, Stuart Biddle, Kyra Hamilton, Arto Laukkanen, Kaisa Aunola, Derwin King Chan, Nelli Hankonen, Mary Hassandra, Tommi Kärkkäinen, Virpi-Liisa Kykyri, Juho Polet, Ryan Rhodes, Montse C Ruiz, Arja Sääkslahti, Jekaterina Schneider, Hanna-Mari Toivonen, Taru Lintunen, Martin Hagger, Keegan Knittle. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 21.03.2024.)
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- 2024
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33. The influence of interactions with pet dogs on psychological distress.
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Matijczak A, Yates MS, Ruiz MC, Santos LR, Kazdin AE, and Raila H
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- Humans, Male, Dogs, Female, Animals, Adult, Middle Aged, Aged, Self Report, Attitude, Anxiety, Human-Animal Bond, Psychological Distress
- Abstract
Many people, including nearly half of American households, own a pet dog. Previous work has found that therapy dog interactions reduce distress, but little work to date has empirically established the mood-enhancing effects of interaction with one's own pet dog. In this study, dog owners ( N = 73; 86.3% female, 13.7% male; age 25-77 years) underwent a stress-inducing task followed by random assignment to either (a) interacting with their dog ( n = 24), (b) an expectancy control ( n = 25; "stress-reducing" coloring books), or (c) a waiting control ( n = 24). We compared the effects of each condition on affect and state anxiety. Participants assigned to the dog interaction showed greater increases in positive affect, as well as greater reductions in anxiety compared to both expectancy and waiting controls ( d s > 0.72, p s < .018). No significant reductions in negative affect were detected. Second, we found that self-reported experiences with animals, attitudes toward animals, or bondedness with their dog did not differentially predict the condition's impact on the owner's mood. Finally, we coded participants' degree of engagement (e.g., time spent playing) with the dog and found that higher engagement predicted reduced negative affect. Overall, interacting with one's own pet dog reduced owners' distress. Such interactions, which occur commonly in daily life, may have the potential to alleviate distress at a large scale. Precisely how this works and for whom it is especially well suited remain intriguing open questions. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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- 2024
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34. Burnout syndrome in Spanish, Portuguese and Latin American ophthalmologists: a cross-sectional analysis.
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Garrido-Hermosilla AM, Soto-Sierra M, Díaz-Ruiz MC, Gutiérrez-Sánchez E, and Rodríguez-de-la-Rúa-Franch E
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- Humans, Cross-Sectional Studies, Portugal epidemiology, Latin America epidemiology, Burnout, Psychological, Surveys and Questionnaires, Ophthalmologists, Burnout, Professional epidemiology, Burnout, Professional psychology, Psychological Tests, Self Report
- Abstract
Purpose: Despite the well-known consequences of burnout syndrome, there has been little research into this syndrome in the field of ophthalmology. Our objective is to determine the frequency of burnout syndrome between Spanish, Portugal and Latin-American ophthalmologists, as well as to analyse its relationship with different sociodemographic variables., Methods: This is an observational cross-sectional descriptive study including ophthalmologists from Spain, Portugal and 15 Latin American countries. Burnout syndrome was evaluated by the Maslach Burnout Inventory-Human Services Survey. Burnout syndrome was defined as high emotional exhaustion, high depersonalization or low personal accomplishment. In addition, we recorded sociodemographic variables and aspects related to the type of work. A conditional backwards stepwise multivariate binomial logistic regression analysis was run to assess the variables associated with burnout syndrome, expressed as an odds ratio (OR)., Results: A total of 527 surveys were analysed, the majority from Spain (401; 76.1%), followed by Argentina (45; 8.5%), and Mexico (31; 5.9%). The number of ophthalmologists with burnout syndrome was 351 (66.6%). The results show the profile of a young ophthalmologist (age OR 0.985), carrying out a public activity (OR 2.118) and dedicated to general ophthalmology (OR 1.860)., Conclusions: The frequency detected in this study confirms a steady increase in rates of burnout among ophthalmologists. As the consequences of this are well known, it is vital for health centre managers to develop a strategic plan to allow the causes to be understood better and to implement steps to improve the situation in each medical centre., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2024
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35. Evisceration of a globe with large scleromalacia and uveal prolapse after vegetal chemical burn.
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Garrido-Hermosilla AM, Girón-Ortega M, and Díaz-Ruiz MC
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- Humans, Eye Evisceration, Prolapse, Burns, Chemical, Eye Injuries
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- 2023
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36. Perfection behind the whistle: Perfectionism and perceived performance in soccer referees.
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Robazza C, Sivilli P, Bortoli L, and Ruiz MC
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Purpose: The purpose of the study was to examine the relationship between self-oriented perfectionism, socially prescribed perfectionism, cognitive appraisals, psychobiosocial experiences, and self-evaluated performance in soccer referees, using the multi-states (MuSt) theory as the theoretical framework., Method: Participants were 67 soccer referees (57 men and 10 women, M
age = 23.03 years, SD = 2.71) with 3-15 years ( M = 7.36, SD = 2.44) of refereeing experience in first-class, promotion, or excellence matches. They completed questionnaires assessing perfectionism, competitive appraisals, and psychobiosocial experiences two days before a game, and self-evaluated their performance one day after the event., Results: Results revealed significant positive correlations ( r > 0.20) between self-oriented perfectionism and socially prescribed perfectionism with challenge appraisals, functional psychobiosocial experiences, and self-evaluated performance. Serial multiple mediation analyses showed positive indirect effects of both self-oriented and socially prescribed perfectionism on self-evaluated performance via challenge appraisals and psychobiosocial experiences ( β = 0.023, 95 % CI = 0.000, 0.097, and β = 0.097, 95 % CI = 0.003, 0.253, respectively)., Conclusion: The findings suggest that both dimensions of perfectionism may positively influence perceived performance when viewed as a positive challenge and associated with functional experiences. The study advances our understanding of the effects of perfectionism on perceived performance in the context of soccer refereeing. Practical implications for referee training programs are provided., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors. Published by Elsevier Ltd.)- Published
- 2023
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37. Endothelial progenitor cells as biomarkers of diabetes-related cardiovascular complications.
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Benítez-Camacho J, Ballesteros A, Beltrán-Camacho L, Rojas-Torres M, Rosal-Vela A, Jimenez-Palomares M, Sanchez-Gomar I, and Durán-Ruiz MC
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- Humans, Blood Glucose metabolism, Biomarkers metabolism, Endothelial Progenitor Cells metabolism, Diabetes Mellitus metabolism, Diabetic Angiopathies metabolism
- Abstract
Diabetes mellitus (DM) constitutes a chronic metabolic disease characterized by elevated levels of blood glucose which can also lead to the so-called diabetic vascular complications (DVCs), responsible for most of the morbidity, hospitalizations and death registered in these patients. Currently, different approaches to prevent or reduce DM and its DVCs have focused on reducing blood sugar levels, cholesterol management or even changes in lifestyle habits. However, even the strictest glycaemic control strategies are not always sufficient to prevent the development of DVCs, which reflects the need to identify reliable biomarkers capable of predicting further vascular complications in diabetic patients. Endothelial progenitor cells (EPCs), widely known for their potential applications in cell therapy due to their regenerative properties, may be used as differential markers in DVCs, considering that the number and functionality of these cells are affected under the pathological environments related to DM. Besides, drugs commonly used with DM patients may influence the level or behaviour of EPCs as a pleiotropic effect that could finally be decisive in the prognosis of the disease. In the current review, we have analysed the relationship between diabetes and DVCs, focusing on the potential use of EPCs as biomarkers of diabetes progression towards the development of major vascular complications. Moreover, the effects of different drugs on the number and function of EPCs have been also addressed., (© 2023. The Author(s).)
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- 2023
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38. Food-sensitized pediatric patients show colonic cow's milk protein-specific Th2 cells.
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Canziani KE, Ruiz MC, Candia MR, Ilid M, Feregotti E, Curciarello R, Álvarez MC, Guzmán L, Bernedo V, García M, Bohle B, Docena GH, and Muglia CI
- Subjects
- Animals, Female, Child, Humans, Cattle, Infant, Th2 Cells metabolism, Interleukin-4, Interleukin-13 metabolism, Allergens, Milk Proteins, Colon, Immunoglobulin E, Milk Hypersensitivity, Food Hypersensitivity
- Abstract
Food allergies have become a health concern worldwide. Around 6% to 10% of children are allergic to cow's milk proteins. We have previously characterized colorectal polyps in patients sensitized to food allergens. These polyps are classified as inflammatory and present a type 2 environment, with elevated interleukin (IL)-13 and IL-4, and are a site of immunoglobulin E synthesis. In this study, we characterized and isolated cow's milk protein-specific T cell lines and T cell clones from the lamina propria of polyps from patients sensitized to these proteins. Isolated T cells responded to cow's milk proteins similarly to peripheral blood T cells, showing antigen-specific cell proliferation and Th2 cytokines release in vitro. T cell clones obtained were all CD4+ T cells and expressed the membrane TCRαβ receptor and secreted higher IL-4, IL-5, and IL-13 amounts than unstimulated cells, whereas interferon γ secretion remained unchanged. Remarkably, the gut homing chemokine receptor CCR9 was augmented in cow's milk-specific peripheral and lamina propria T cells, and CCL25 was found to be expressed in the inflammatory polyp tissue and not in the adjacent mucosa. In conclusion, we isolated and characterized cow's milk-specific lamina propria CD4+ Th2 cells from colonic inflammatory polyps. CCR9 expression on these cells, along with increase secretion of CCL25 in the polyp, favors recruitment and cow's milk-specific allergic response within the inflammatory polyp tissue. Our findings may be critical to understand the underlying mechanism that promotes immunoglobulin E synthesis in the colon of cow's milk proteins allergic patients, contributing to the development of novel T cell-targeted immunotherapies., Competing Interests: Conflict of interest statement. The authors declare no conflicts of interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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39. Changes in the Acetylcholinesterase Enzymatic Activity in Tumor Development and Progression.
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Pérez-Aguilar B, Marquardt JU, Muñoz-Delgado E, López-Durán RM, Gutiérrez-Ruiz MC, Gomez-Quiroz LE, and Gómez-Olivares JL
- Abstract
Acetylcholinesterase is a well-known protein because of the relevance of its enzymatic activity in the hydrolysis of acetylcholine in nerve transmission. In addition to the catalytic action, it exerts non-catalytic functions; one is associated with apoptosis, in which acetylcholinesterase could significantly impact the survival and aggressiveness observed in cancer. The participation of AChE as part of the apoptosome could explain the role in tumors, since a lower AChE content would increase cell survival due to poor apoptosome assembly. Likewise, the high Ach content caused by the reduction in enzymatic activity could induce cell survival mediated by the overactivation of acetylcholine receptors (AChR) that activate anti-apoptotic pathways. On the other hand, in tumors in which high enzymatic activity has been observed, AChE could be playing a different role in the aggressiveness of cancer; in this review, we propose that AChE could have a pro-inflammatory role, since the high enzyme content would cause a decrease in ACh, which has also been shown to have anti-inflammatory properties, as discussed in this review. In this review, we analyze the changes that the enzyme could display in different tumors and consider the different levels of regulation that the acetylcholinesterase undergoes in the control of epigenetic changes in the mRNA expression and changes in the enzymatic activity and its molecular forms. We focused on explaining the relationship between acetylcholinesterase expression and its activity in the biology of various tumors. We present up-to-date knowledge regarding this fascinating enzyme that is positioned as a remarkable target for cancer treatment.
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- 2023
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40. Passion in hiking guides affects their group management skills and functional psychobiosocial experiences.
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Morsiani M, Robazza C, Di Liborio M, Ruiz MC, and Bortoli L
- Abstract
Using the individual zones of optimal functioning model as a conceptual framework, the purpose of this study was to examine the interplay between passion, perceived group management skills, and functional emotion-related (psychobiosocial) experiences in hiking guides. The participants were 60 Italian hiking guides, 47 men and 13 women, aged 32-74 years ( M = 57.25, SD = 10.49). They were asked to fill in an online questionnaire containing measures of harmonious and obsessive passion, perceived group management skills, and psychobiosocial experiences. Path analysis results showed positive indirect effects of both harmonious passion and obsessive passion on psychobiosocial experiences via group management skills. Additional results from moderated moderation suggest that high levels of obsessive passion, combined with low levels of both harmonious passion and perceived group management skills, are associated with lower intensity levels of psychobiosocial experiences. The findings contribute to increasing our understanding of the overall experience of hiking guides, and the important role they play in motivating people to engage in physical activity in a natural environment., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)
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- 2023
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41. Athletes' basic psychological needs and emotions: the role of cognitive reappraisal.
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Robazza C, Morano M, Bortoli L, and Ruiz MC
- Abstract
In sport, where high achievements are at stake, athletes often feel pressure and emotions that hinder their performance. Emotion regulation becomes essential for athletes to handle stress, achieve optimal performance, and enhance their overall well-being. To advance both research and practical applications, it is crucial to examine the antecedents of emotion regulation and the impact on emotions and other feelings associated with performance. Specifically, the purpose of this cross-sectional study was to examine the role of athletes' emotion regulation strategies (i.e., cognitive reappraisal and expressive suppression) in the relationship between basic psychological needs satisfaction, emotions, and psychobiosocial experiences. The sample consisted of 424 competitive athletes (246 men and 178 women) involved in individual sports ( n = 164; e.g., fencing, gymnastics, martial arts, swimming, and tennis) or team sports ( n = 260; e.g., basketball, rugby, soccer, and volleyball), aged 16-36 years ( M = 23.08, SD = 7.65). Their competitive experience ranged from 1 to 21 years ( M = 9.71, SD = 6.34) at regional (71%), national (18%), or international (11%) level, and they practiced their sport on average 3.74 times a week ( SD = 1.73). Participants completed measures of basic needs satisfaction (i.e., competence, autonomy, and relatedness), emotion regulation style, emotions, and psychobiosocial experiences. Structural equation modeling results showed that competence need satisfaction was positively associated with pleasant emotions and psychobiosocial experiences that are perceived as functional for performance, and negatively associated with a maladaptive emotion regulation style (i.e., expressive suppression) and unpleasant emotions. Relatedness need satisfaction was positively related to an adaptive emotion regulation style (i.e., cognitive reappraisal), pleasant emotions, and psychobiosocial experiences, and negatively related to expressive suppression and unpleasant emotions. Finally, mediation analysis showed positive indirect effects from autonomy and relatedness satisfaction to pleasant emotions and psychobiosocial experiences via cognitive reappraisal. Findings suggest that the satisfaction of athletes' basic psychological needs of autonomy and relatedness is related to the experience of pleasant emotions and functional psychobiosocial states when they adopt an adaptive emotion regulation style., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Robazza, Morano, Bortoli and Ruiz.)
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- 2023
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42. Women health providers: materials on cures, remedies and sexuality in inquisitorial processes (15th-18th century).
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Espina-Jerez B, Siles-González J, Solano-Ruiz MC, and Gómez-Cantarino S
- Abstract
Background: The first inquisitorial trials were against Muslims and Jews. Later, they focused on women, especially caregivers. Progressively, they were linked to witchcraft and sorcery because of their great care, generational and empirical knowledge. The historiography of health in the 15th-18th centuries still has important bibliographical and interpretative gaps in the care provided by women., Objective: To analyse the care provided by healers as health providers, accused by the Inquisition, justifying the importance of nursing in the diversity of community care in the 15th-18th centuries., Method: A scoping review was conducted following the Dialectical Structural Model of Care (DSMC). A database search was conducted for the period 2013-2022. Bibliographic and legislative resources were used. Cases and convictions from Castilla la Nueva were found in the National Historical Archive and the Diocesan Archive of Cuenca., Results: The concepts of healer, witch and sorceress envolved during the study period. They reflect and reveal the collective imaginary of the social structure. They had healing laboratories, practised psychological and sexual care. They used to accompany their therapeutic action with prayers and amulets. They shared their professional activity with their main denouncers, doctors, apothecaries and priests. They were usually women in socially vulnerable situations, who did not conform to social stereotypes., Conclusions: They were predecessors of today's nursing, they overcame socio-cultural difficulties, although they were condemned for it. Healers did not manage to regulate their profession, but they acted as agents of health in a society that demanded them while participating in the "witch-hunt"., Competing Interests: Misnamed “La Coracha”, she was accused of witchcraft and superstitious cures, which led to a trial of faith in the early 18th century (National Historical Archive, 1703). When the Tribunal is informed of Catalina’s activities, an information letter is sent to the area commissioner, requesting further investigation of the elements of the statement with appropriate witnesses. The original letter states the following against Catalina: ”(.) there is a woman in the Va de Hita who is misnamed la Coracha, who has the custom of sanctifying and cure animals, healing them with different things and the main one is with partridge feathers, and that she makes psalms and that to cure and to know the evil eye they bring her some jewels from the sick person and with them she knows the damage; and lastly, he does and says such nonsense that it has caused a great scandal in the town; and that the Apothecary and the priest of San Pedro and others that they could cite would testify at length about all this (.)”. (National Historical Archive, 1703) [1]. In this statement, in addition to the account of their practices, the complainants, both opponents, one in professional matters and the other in moral-religious matters, stand out. Finally, however, it is equally appropriate to highlight the conclusion of the commissioner who analysed and closed the case, who determined that the witnesses were not telling the truth.The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Espina-Jerez, Siles-González, Solano-Ruiz and Gómez-Cantarino.)
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- 2023
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43. [Some reflections on the mental state of the second victims of COVID-19 in intensive care units].
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Diaz A, Astochado F, Moya-Salazar J, Rojas-Zumaran V, Ruiz MC, Vasquez AN, and Alcarraz C
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- Humans, Intensive Care Units, COVID-19 epidemiology
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- 2023
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44. Brief emotional eating scale: A multinational study of factor structure, validity, and invariance.
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Ruiz MC, Devonport TJ, Chen-Wilson CJ, Nicholls W, Cagas JY, Fernandez-Montalvo J, Choi Y, Gan Y, and Robazza C
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- Psychometrics, Reproducibility of Results, Self Report, Factor Analysis, Statistical, Surveys and Questionnaires, Emotions, Craving
- Abstract
Emotional eating or the tendency to eat in response to emotional states can be assessed using self-report measures. The Emotional Eating Scale-II is a commonly used and reliable instrument that measures the desire to eat in response to a range of unpleasant and pleasant emotions. The current study aimed to corroborate the validity of the EES-II and expand its utility by investigating its dimensionality and testing its measurement invariance in samples from English-speaking and non-English-speaking countries. Convergent and predictive validity in respect of food craving, eating, and health indicators were also examined. This cross-national study included a total of 2485 adult participants recruited from Finland, North America, Philippines, United Kingdom, China, Italy, Spain, and South Korea, who completed the EES-II in six different languages. Factor analyses supported a four-factor structure including valence (pleasant, unpleasant) and activation (high, low) for a 12-item English version and slightly modified non-English adaptations. The model exhibited good fit in all samples, and convergent validity was demonstrated. Full invariance of factor loadings and partial invariance of factor loading, intercepts, and error variances was established across samples. Structural equation models revealed that high activation (pleasant and unpleasant) states predicted food cravings and reported eating. Overall findings across multiple samples and countries supported the factorial structure, reliability, invariance, and validity of the resulting Brief Emotional Eating Scale (BEES)., Competing Interests: Declaration of competing interest None., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2023
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45. The hepatic effects of GDF11 on health and disease.
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Gerardo-Ramírez M, German-Ramirez N, Escobedo-Calvario A, Chávez-Rodríguez L, Bucio-Ortiz L, Souza-Arroyo V, Miranda-Labra RU, Gutiérrez-Ruiz MC, and Gomez-Quiroz LE
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- Heart, Liver metabolism, Growth Differentiation Factors metabolism, Growth Differentiation Factors pharmacology, Muscle, Skeletal metabolism
- Abstract
The growth differentiation factor 11 (GDF11), a member of the superfamily of the transforming growth factor β, has gained relevance in the last few years due to its remarkable effects in cellular biology, particularly in the nervous system, skeletal muscle, the heart, and many epithelial tissues. Some controversies have been raised about this growth factor. Many of them have been related to technical factors but also the nature of the cellular target. In liver biology and pathobiology, the GDF11 has shown to be related in many molecular aspects, with a significant impact on the physiology and the initiation and progression of the natural history of liver diseases. GDF11 has been involved as a critical regulator in lipid homeostasis, which, as it is well known, is the first step in the progression of liver disease. However, also it has been reported that the GDF11 is involved in fibrosis, senescence, and cancer. Although there are some controversies, much of the literature indicates that GDF11 displays effects tending to solve or mitigate pathological states of the liver, with reasonable evidence of correlation with other organs or systems. To a large extent, the controversy, as mentioned, is due to technical problems, such as the specificity of GDF11 antibodies, confusion with its closer family member, myostatin, and the state of differentiation in the tissues. In the present work, we reviewed the specific effects of GDF11 in the biology and pathobiology of the liver as a potential and promising factor for therapeutic intervention shortly., Competing Interests: Declaration of competing interest The authors indicate no conflict of interest., (Copyright © 2022 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.)
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- 2023
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46. Perfectionism and performance-related psychobiosocial states: The mediating role of competition appraisals.
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Ruiz MC, Appleton PR, Duda JL, Bortoli L, and Robazza C
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- Humans, Male, Female, Adolescent, Young Adult, Adult, Motivation, Personality, Athletes psychology, Perfectionism, Athletic Performance psychology
- Abstract
Using the multi-states (MuSt) theory as a framework, the present study focused on the individual (personality) antecedents of psychobiosocial states. Psychobiosocial states comprise emotional subjective experiences and their correlates (cognitive, motivational, volitional, bodily, motor-behavioural, operational, and communicative), that can be functional for performance (helpful) or dysfunctional (harmful). Specifically, we examined the relationships between two perfectionism dimensions (perfectionistic strivings and concerns) and functional and dysfunctional psychobiosocial states. The hypothesized mediational role of competitive appraisals was also tested. Participants ( N = 271, 138 female, 133 male, M age = 22.74 ± 7.01) completed questionnaires assessing the targeted variables. Structural equation modelling revealed that perfectionistic strivings were positive predictors of functional states directly and via challenge appraisals. On the other hand, perfectionistic concerns were positive predictors of dysfunctional states directly and via threat appraisals. Results provide support to MuSt theory and extend the literature on the antecedents of athletes' performance-related feeling states. Findings also provide support for the holistic conceptualization of psychobiosocial states encompassing the functionality dimension. The results highlight the importance of developing interventions aimed at helping athletes high in perfectionistic concerns evaluate situations as a challenge (and less of a threat) and increasing their perceived resources. Highlights Perfectionistic strivings positively related to functional psychobiosocial statesPerfectionistic concerns positively related to dysfunctional psychobiosocial statesCompetitive challenge appraisals mediated the relationship between perfectionistic strivings and functional psychobiosocial statesCompetitive threat appraisals mediated the relationship between perfectionistic concerns and dysfunctional psychobiosocial states.
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- 2023
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47. Clinical, histopathologic, immunohistochemical, and electron microscopic findings in cutaneous monkeypox: A multicenter retrospective case series in Spain.
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Rodríguez-Cuadrado FJ, Nájera L, Suárez D, Silvestre G, García-Fresnadillo D, Roustan G, Sánchez-Vázquez L, Jo M, Santonja C, Garrido-Ruiz MC, Vicente-Montaña AM, Rodríguez-Peralto JL, and Requena L
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- Humans, Retrospective Studies, Spain, Electrons, Necrosis, Mpox (monkeypox) pathology
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Background: The worldwide outbreak of monkeypox has evidenced the usefulness of the dermatologic manifestations for its diagnosis., Objective: To describe the histopathologic and immunohistochemical findings of monkeypox cutaneous lesions., Methods: This is a retrospective histopathologic and immunohistochemical study of 20 patients with positive Monkeypox virus DNA polymerase chain reaction and immunohistochemical positivity for Vaccinia virus in cutaneous lesions. Four cases were also examined by electron microscopy., Results: The most characteristic histopathologic findings consisted of full-thickness epidermal necrosis with hyperplasia and keratinocytic ballooning at the edges. In some cases, the outer root sheath of the hair follicle and the sebaceous gland epithelium were affected. Intraepithelial cytoplasmic inclusion bodies and scattered multinucleated keratinocytes were occasionally found. Immunohistochemically, strong positivity with anti-Vaccinia virus antibody was seen in the cytoplasm of ballooned keratinocytes. Electron microscopy study demonstrated numerous viral particles of monkeypox in affected keratinocytes., Limitations: Small sample size. Electron microscopic study was only performed in 4 cases., Conclusion: Epidermal necrosis and keratinocytic ballooning are the most constant histopathologic findings. Immunohistochemical positivity for Vaccinia virus was mostly detected in the cytoplasm of the ballooned keratinocytes. These findings support the usefulness of histopathologic and immunohistochemical studies of cutaneous lesions for diagnosis of monkeypox., Competing Interests: Conflicts of interest None disclosed., (Copyright © 2022 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
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- 2023
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48. Erk1/2 signaling mediates the HGF-induced protection against ethanol and acetaldehyde-induced toxicity in the pancreatic RINm5F cell line.
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Palestino-Domínguez M, Escobedo-Calvario A, Salas-Silva S, Vergara-Mendoza M, Souza-Arroyo V, Lazzarini R, Miranda-Labra R, Bucio-Ortiz L, Gutiérrez-Ruiz MC, and Gomez-Quiroz LE
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- Cell Line, Hepatocyte Growth Factor, Pancreas metabolism, MAP Kinase Signaling System, Acetaldehyde toxicity, Acetaldehyde metabolism, Ethanol toxicity
- Abstract
Alcohol-induced pancreas damage remains as one of the main risk factors for pancreatitis development. This disorder is poorly understood, particularly the effect of acetaldehyde, the primary alcohol metabolite, in the endocrine pancreas. Hepatocyte growth factor (HGF) is a protective protein in many tissues, displaying antioxidant, antiapoptotic, and proliferative responses. In the present work, we were focused on characterizing the response induced by HGF and its protective mechanism in the RINm5F pancreatic cell line treated with ethanol and acetaldehyde. RINm5F cells were treated with ethanol or acetaldehyde for 12 h in the presence or not of HGF (50 ng/ml). Cells under HGF treatment decreased the content of reactive oxygen species and lipid peroxidation induced by both toxics, improving cell viability. This effect was correlated to an improvement in insulin expression impaired by ethanol and acetaldehyde. Using a specific inhibitor of Erk1/2 abrogated the effects elicited by the growth factor. In conclusion, the work provides mechanistic evidence of the HGF-induced-protective response to the alcohol-induced damage in the main cellular component of the endocrine pancreas., (© 2023 Wiley Periodicals LLC.)
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- 2023
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49. Spermiogenesis alterations in the absence of CTCF revealed by single cell RNA sequencing.
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Torres-Flores U, Díaz-Espinosa F, López-Santaella T, Rebollar-Vega R, Vázquez-Jiménez A, Taylor IJ, Ortiz-Hernández R, Echeverría OM, Vázquez-Nin GH, Gutierrez-Ruiz MC, De la Rosa-Velázquez IA, Resendis-Antonio O, and Hernández-Hernandez A
- Abstract
CTCF is an architectonic protein that organizes the genome inside the nucleus in almost all eukaryotic cells. There is evidence that CTCF plays a critical role during spermatogenesis as its depletion produces abnormal sperm and infertility. However, defects produced by its depletion throughout spermatogenesis have not been fully characterized. In this work, we performed single cell RNA sequencing in spermatogenic cells with and without CTCF. We uncovered defects in transcriptional programs that explain the severity of the damage in the produced sperm. In the early stages of spermatogenesis, transcriptional alterations are mild. As germ cells go through the specialization stage or spermiogenesis, transcriptional profiles become more altered. We found morphology defects in spermatids that support the alterations in their transcriptional profiles. Altogether, our study sheds light on the contribution of CTCF to the phenotype of male gametes and provides a fundamental description of its role at different stages of spermiogenesis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Torres-Flores, Díaz-Espinosa, López-Santaella, Rebollar-Vega, Vázquez-Jiménez, Taylor, Ortiz-Hernández, Echeverría, Vázquez-Nin, Gutierrez-Ruiz, De la Rosa-Velázquez, Resendis-Antonio and Hernández-Hernandez.)
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- 2023
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50. Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients.
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Beltrán-Camacho L, Bhosale SD, Sánchez-Morillo D, Sánchez-Gomar I, Rojas-Torres M, Eslava-Alcón S, Martínez-Torija M, de Infante MAR, Nieto-Martín MD, Rodríguez-Iglesias MA, Moreno JA, Berrocoso E, Larsen MR, Moreno-Luna R, and Durán-Ruiz MC
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- Humans, Proteomics, SARS-CoV-2, Immunoglobulin G, Cells, Cultured, Membrane Proteins, Calpain, COVID-19, Cardiovascular System
- Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection significantly affects the cardiovascular system, causing vascular damage and thromboembolic events in critical patients. Endothelial dysfunction represents one of the first steps in response to COVID-19 that might lead to cardiovascular complications and long-term sequelae. However, despite the enormous efforts in the last two years, the molecular mechanisms involved in such processes remain poorly understood. Herein, we analyzed the protein changes taking place in endothelial colony forming cells (ECFCs) after the incubation with the serum from individuals infected with COVID-19, whether asymptomatic or critical patients, by application of a label free-quantitative proteomics approach. Specifically, ECFCs from healthy individuals were incubated ex-vivo with the serum of either COVID-19 negative donors (PCR-/IgG-, n:8), COVID-19 asymptomatic donors at different infective stages (PCR+/ IgG-, n:8and PCR-/IgG+, n:8), or hospitalized critical COVID-19 patients (n:8), followed by proteomics analysis. In total, 590 proteins were differentially expressed in ECFCs in response to all infected serums. Predictive analysis highlighted several proteins like CAPN5, SURF4, LAMP2 or MT-ND1, as highly discriminating features between the groups compared. Protein changes correlated with viral infection, RNA metabolism or autophagy, among others. Remarkably, the angiogenic potential of ECFCs in response to the infected serums was impaired, and many of the protein alterations in response to the serum of critical patients were associated with cardiovascular-related pathologies., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)
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- 2023
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