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7 results on '"Ruiz De Assin Alonso, R."'

1. OOCYTE VITRIFICATION IMPACTS THE EMBRYO DEVELOPMENT BUT NOT THE EUPLOIDY RATE

Author

Rubino, P., primary, Ruiz de Assin Alonso, R., additional, Konate, N., additional, Tapia, L., additional, Mazmanian, K., additional, Guan, L., additional, Dearden, L., additional, Thiel, A., additional, Moon, C., additional, Kolb, B., additional, Norian, J.M., additional, Nelson, J., additional, Wilcox, J., additional, and Tan, T., additional

Published
2020
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2. The blastocyst re-expansion status after thawing do not seem to affect the clinical outcomes in freeze all preimplantation genetic testing (PGT) cycles

Author

Rubino, P., primary, Ruiz de Assin Alonso, R., additional, Dearden, L., additional, Guan, L., additional, Mazmanian, K., additional, Tapia, L., additional, Thiel, A., additional, Kolb, B., additional, Wilcox, J., additional, Nelson, J., additional, Norian, J., additional, and Tan, T., additional

Published
2019
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3. Embryos classified as low-grade mosaic (<50%) after preimplantation genetic screening (PGS) can have the same competence of producing healthy newborns as euploid embryos

Author

Rubino, P., primary, Dearden, L., additional, Ruiz de Assin Alonso, R., additional, Guan, L., additional, Mazmanian, K.N., additional, Thiel, A., additional, Hernandez, L., additional, Li, X., additional, Sinogaya, P., additional, Lew, J., additional, Nelson, J., additional, Norian, J.M., additional, Kolb, B., additional, Wilcox, J.G., additional, and Tan, T., additional

Published
2018
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5. Embryos classified as low-grade mosaic (<50%) after preimplantation genetic screening (PGS) by means of high resolution next-generation screening (hr-NGS), can have the same competence of producing healthy newborns as euploid embryos

Author

Rubino, P., primary, Li, X., additional, Ruiz De Assin Alonso, R., additional, Mazmanian, K., additional, Guan, L., additional, Dearden, L., additional, Tapia, L., additional, Thiel, A., additional, Kolb, B., additional, Nelson, J., additional, Norian, J., additional, Wilcox, J., additional, Lew, J., additional, Sinogaya, P., additional, and Tih, Tan, additional

Published
2018
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6. Preimplantation genetic screening (PGS) in egg donor (ED) cycles: is it a valid option?

Author

Ruiz De Assin Alonso, R., primary, Rubino, P., additional, Mazmanian, K., additional, Guan, L., additional, Dearden, L., additional, Tapia, L., additional, Thiel, A., additional, Kolb, B., additional, Nelson, J., additional, Norian, J., additional, Wilcox, J., additional, Li, X., additional, Lew, J., additional, Sinogaya, P., additional, and Tih, Tan, additional

Published
2018
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7. Trophectoderm biopsy protocols can affect clinical outcomes: time to focus on the blastocyst biopsy technique.

Author

Rubino P, Tapia L, Ruiz de Assin Alonso R, Mazmanian K, Guan L, Dearden L, Thiel A, Moon C, Kolb B, Norian JM, Nelson J, Wilcox J, and Tan T

Subjects
Aneuploidy, Female, Humans, Live Birth, Predictive Value of Tests, Pregnancy, Pregnancy Rate, Retrospective Studies, Risk Assessment, Risk Factors, Treatment Outcome, Biopsy adverse effects, Blastocyst pathology, Embryo Transfer adverse effects, Fertilization in Vitro adverse effects, Genetic Testing, Preimplantation Diagnosis adverse effects
Abstract

Objective: To compare two different blastocyst biopsy protocols., Design: Retrospective single-center cohort study., Settings: Private in vitro fertilization center., Patient(s): The study included 1,670 frozen-thawed embryo transfers (FETs) with preimplantation genetic testing for aneuploidy (PGT-A)., Intervention: None., Main Outcome Measure(s): Survival rate (SR) after thawing, clinical pregnancy rate (CPR), ongoing implantation rate (IR), and live birth rate (LBR)., Result(s): Eight hundred thirty-five FETs with PGT-A cycles including only embryos biopsied in the sequential blastocyst hatching and biopsy protocol paired with the ablation of one-fourth of the zona pellucida (ZP) were matched with 835 FETs with PGT-A cycles including only embryos biopsied in the day 3 prehatching protocol by female age (±1 year), number of embryos transferred, use of gestational carrier or egg donor, and day of blastocyst transfer. Only FETs with euploid blastocysts graded no lower than 4BB were included, and cycles with fewer than five oocytes were excluded. SR after thawing, CPR, ongoing IR, and LBR were significantly higher in the FET cycles with the embryos biopsied in the sequential hatching and biopsy protocol. Four cases of monozygotic twin pregnancies were reported with the day 3 prehatching protocol and none with the sequential hatching and biopsy protocol., Conclusion(s): Our results show, for the first time, that using different blastocyst biopsy protocols can affect clinical outcomes. Because the study was retrospective, our findings should be validated in a prospective trial., (Copyright © 2019 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2020
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