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1. Management of patients with hypertension and chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. On behalf of the European Society of Hypertension Working Group on Hypertension and the Kidney

Author: Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Jaén Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Jaén Águila F, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg F, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre I, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, der Niepen PV, Veglio F, Venzin R, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, Vogt L., Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Jaén Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Jaén Águila F, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg F, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre I, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, der Niepen PV, Veglio F, Venzin R, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, and Vogt L.
Abstract: Objective Real-life management of patients with hypertension and chronic kidney disease (CKD) among European Society of Hypertension Excellence Centres (ESH-ECs) is unclear : we aimed to investigate it. Methods A survey was conducted in 2023. The questionnaire contained 64 questions asking ESH-ECs representatives to estimate how patients with CKD are managed. Results Overall, 88 ESH-ECS representatives from 27 countries participated. According to the responders, renin-angiotensin system (RAS) blockers, calcium-channel blockers and thiazides were often added when these medications were lacking in CKD patients, but physicians were more prone to initiate RAS blockers (90% [interquartile range: 70–95%]) than MRA (20% [10–30%]), SGLT2i (30% [20–50%]) or (GLP1-RA (10% [5–15%]). Despite treatment optimisation, 30% of responders indicated that hypertension remained uncontrolled (30% (15–40%) vs 18% [10%–25%]) in CKD and CKD patients, respectively). Hyperkalemia was the most frequent barrier to initiate RAS blockers, and dosage reduction was considered in 45% of responders when kalaemia was 5.5–5.9 mmol/L. Conclusions RAS blockers are initiated in most ESH-ECS in CKD patients, but MRA and SGLT2i initiations are less frequent. Hyperkalemia was the main barrier for initiation or adequate dosing of RAS blockade, and RAS blockers’ dosage reduction was the usual management.
Published: 2024

2. Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire

Author: Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, Van der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Águila FJ, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg FP, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre IM, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, Van der Niepen P, Veglio F, Venzin RM, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, Vogt L, Halimi, J, Sarafidis, P, Azizi, M, Bilo, G, Burkard, T, Bursztyn, M, Camafort, M, Chapman, N, Cottone, S, de Backer, T, Deinum, J, Delmotte, P, Dorobantu, M, Doumas, M, Dusing, R, Duly-Bouhanick, B, Fauvel, J, Fesler, P, Gaciong, Z, Gkaliagkousi, E, Gordin, D, Grassi, G, Grassos, C, Guerrot, D, Huart, J, Izzo, R, Águila, F, Járai, Z, Kahan, T, Kantola, I, Kociánová, E, Limbourg, F, Lopez-Sublet, M, Mallamaci, F, Manolis, A, Marketou, M, Mayer, G, Mazza, A, Macintyre, I, Mourad, J, Muiesan, M, Nasr, E, Nilsson, P, Oliveras, A, Ormezzano, O, Paixão-Dias, V, Papadakis, I, Papadopoulos, D, Perl, S, Polónia, J, Pontremoli, R, Pucci, G, Robles, N, Rubin, S, Ruilope, L, Rump, L, Saeed, S, Sanidas, E, Sarzani, R, Schmieder, R, Silhol, F, Sokolovic, S, Solbu, M, Soucek, M, Stergiou, G, Sudano, I, Tabbalat, R, Tengiz, I, Triantafyllidi, H, Tsioufis, K, Václavík, J, van der Giet, M, Van der Niepen, P, Veglio, F, Venzin, R, Viigimaa, M, Weber, T, Widimsky, J, Wuerzner, G, Zelveian, P, Zebekakis, P, Lueders, S, Persu, A, Kreutz, R, Vogt, L, Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Águila FJ, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg FP, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre IM, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, Van der Niepen P, Veglio F, Venzin RM, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, and Vogt L
Abstract: Objective: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear. Methods: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to estimate preexisting CKD management quality. Results: Overall, 88 ESH-ECs from 27 countries participated (fully completed surveys: 66/88 [75.0%]). ESH-ECs reported that 28% (median, interquartile range: 15-50%) had preexisting CKD, with 10% of them (5-30%) previously referred to a nephrologist, while 30% (15-40%) had resistant hypertension. The reported rate of previous recent (<6 months) estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) testing were 80% (50-95%) and 30% (15-50%), respectively. The reported use of renin-angiotensin system blockers was 80% (70-90%). When a nephrologist was part of the ESH-EC teams the reported rates SGLT2 inhibitors (27.5% [20-40%] vs. 15% [10-25], P = 0.003), GLP1-RA (10% [10-20%] vs. 5% [5-10%], P = 0.003) and mineralocorticoid receptor antagonists (20% [10-30%] vs. 15% [10-20%], P = 0.05) use were greater as compared to ESH-ECs without nephrologist participation. The rate of reported resistant hypertension, recent eGFR and UACR results and management of CKD patients prior to referral varied widely across countries. Conclusions: Our estimation indicates deficits regarding CKD screening, use of nephroprotective drugs and referral to nephrologists before referral to ESH-ECs but results varied widely across countries. This information can be used to build specific programs to improve care in hypertensives with CKD.
Published: 2024

3. Outcomes Following Radiofrequency Renal Denervation According to Antihypertensive Medications: Subgroup Analysis of the Global SYMPLICITY Registry DEFINE

Author: Mahfoud, F, Mancia, G, Schmieder, R, Ruilope, L, Narkiewicz, K, Schlaich, M, Williams, B, Ribichini, F, Weil, J, Almerri, K, Sharif, F, Lauder, L, Wanten, M, Fahy, M, Böhm, M, Mahfoud F., Mancia G., Schmieder R. E., Ruilope L., Narkiewicz K., Schlaich M., Williams B., Ribichini F., Weil J., Almerri K., Sharif F., Lauder L., Wanten M., Fahy M., Böhm M., Mahfoud, F, Mancia, G, Schmieder, R, Ruilope, L, Narkiewicz, K, Schlaich, M, Williams, B, Ribichini, F, Weil, J, Almerri, K, Sharif, F, Lauder, L, Wanten, M, Fahy, M, Böhm, M, Mahfoud F., Mancia G., Schmieder R. E., Ruilope L., Narkiewicz K., Schlaich M., Williams B., Ribichini F., Weil J., Almerri K., Sharif F., Lauder L., Wanten M., Fahy M., and Böhm M.
Abstract: Background: The Global SYMPLICITY Registry DEFINE (Denervation Findings in Real World) investigates radiofrequency renal denervation (RDN) in a broad range of patients with hypertension. We evaluated whether the number or type of antihypertensive medications were associated with increased long-term blood pressure (BP) reductions and cardiovascular outcomes following radiofrequency RDN. Methods: Patients underwent radiofrequency RDN and were categorized by baseline number (0-3 and ≥4) and different combinations of medication classes. BP changes were compared between groups through 36 months. Individual and composite major adverse cardiovascular events were analyzed. Results: Of 2746 evaluable patients, 18% were prescribed 0 to 3 and 82% prescribed ≥4 classes. At 36 months, office systolic BP significantly decreased (P<0.0001) by -19.0±28.3 and -16.2±28.6 mm Hg in the 0 to 3 and ≥4 class groups, respectively. Twenty-four-hour mean systolic BP significantly decreased (P<0.0001) by -10.7±19.7 and -8.9±20.5 mm Hg, respectively. BP reduction was similar between the medication subgroups. Antihypertensive medication classes decreased from 4.6±1.4 to 4.3±1.5 (P<0.0001). Most decreased (31%) or had no changes (47%) to the number of medications, while 22% increased. The number of baseline antihypertensive medication classes was inversely related to the change in prescribed classes at 36 months (P<0.001). Cardiovascular event rates were generally low. More patients in the ≥4 compared with 0 to 3 medication classes had myocardial infarction at 36 months (2.8% versus 0.3%; P=0.009). Conclusions: Radiofrequency RDN reduced BP safely through 36 months, independent of the number and type of baseline antihypertensive medication classes. More patients decreased than increased their number of medications. Radiofrequency RDN is a safe and effective adjunctive therapy regardless of antihypertensive medication regimen. Registration: URL: https://www. Clinicaltrials: gov; Uniqu
Published: 2023

4. Efficacy and safety of finerenone in patients with chronic kidney disease and type 2 diabetes by diuretic use: A FIDELITY analysis

Author: Mentz, R, primary, Anker, S, additional, Pitt, B, additional, Rossing, P, additional, Ruilope, L, additional, Gebel, M, additional, Kolkhof, P, additional, Lawatscheck, R, additional, Rohwedder, K, additional, and Bakris, G, additional
Published: 2023
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5. Effect of finerenone in patients with chronic kidney disease and type 2 diabetes by baseline anaemia status: a FIDELITY analysis

Author: Singh, A, primary, Anker, S D, additional, Filippatos, G, additional, Pitt, B, additional, Rossing, P, additional, Ruilope, L M, additional, Farjat, A E, additional, James, G, additional, Farag, Y M K, additional, Roberts, L, additional, and Bakris, G, additional
Published: 2023
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6. Improved health-related quality of life after renal denervation in patients with resistant hypertension: 3-year outcomes in the global symplicity registry

Author: Mahfoud, F, primary, Weil, J, additional, Mancia, G, additional, Schmieder, R E, additional, Ruilope, L, additional, Schlaich, M, additional, Narkiewicz, K, additional, Williams, B, additional, Fahy, M, additional, and Bohm, M, additional
Published: 2023
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7. Management of hypertension in the very old: aggressive reduction of blood pressure is harmful in most patients

Author: Ruilope, L. M. and Ruiz-Hurtado, G.
Published: 2020
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8. Systemic oxidative stress and circulating long non-coding RNAs as potential novel cardiovascular risk factors in the general population

Author: Sanchez, E. Rodriguez, primary, Mohammed, S., additional, Navarro-García, J., additional, Mercado-García, E., additional, Calvo, E., additional, González-Quintela, A., additional, Ruilope, L., additional, Paneni, F., additional, and Ruiz-Hurtado, G., additional
Published: 2023
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9. Cardiovascular Risk Reduction After Renal Denervation According to Time in Therapeutic Systolic Blood Pressure Range

Author: Mahfoud, F, Mancia, G, Schmieder, R, Ruilope, L, Narkiewicz, K, Schlaich, M, Williams, B, Ribichini, F, Weil, J, Kao, H, Rodriguez-Leor, O, Noory, E, Ong, T, Unterseeh, T, de Araujo Goncalves, P, Zirlik, A, Almerri, K, Sharif, F, Lauder, L, Wanten, M, Fahy, M, Bohm, M, Mahfoud F., Mancia G., Schmieder R. E., Ruilope L., Narkiewicz K., Schlaich M., Williams B., Ribichini F., Weil J., Kao H. -L., Rodriguez-Leor O., Noory E., Ong T. K., Unterseeh T., de Araujo Goncalves P., Zirlik A., Almerri K., Sharif F., Lauder L., Wanten M., Fahy M., Bohm M., Mahfoud, F, Mancia, G, Schmieder, R, Ruilope, L, Narkiewicz, K, Schlaich, M, Williams, B, Ribichini, F, Weil, J, Kao, H, Rodriguez-Leor, O, Noory, E, Ong, T, Unterseeh, T, de Araujo Goncalves, P, Zirlik, A, Almerri, K, Sharif, F, Lauder, L, Wanten, M, Fahy, M, Bohm, M, Mahfoud F., Mancia G., Schmieder R. E., Ruilope L., Narkiewicz K., Schlaich M., Williams B., Ribichini F., Weil J., Kao H. -L., Rodriguez-Leor O., Noory E., Ong T. K., Unterseeh T., de Araujo Goncalves P., Zirlik A., Almerri K., Sharif F., Lauder L., Wanten M., Fahy M., and Bohm M.
Abstract: Background: Renal denervation (RDN) has been shown to lower blood pressure (BP), but its effects on cardiovascular events have only been preliminarily evaluated. Time in therapeutic range (TTR) of BP is associated with cardiovascular events. Objectives: This study sought to assess the impact of catheter-based RDN on TTR and its association with cardiovascular outcomes in the GSR (Global SYMPLICITY Registry). Methods: Patients with uncontrolled hypertension were enrolled and treated with radiofrequency RDN. Office and ambulatory systolic blood pressure (OSBP and ASBP) were measured at 3, 6, 12, 24, and 36 months postprocedure and used to derive TTR. TTR through 6 months was assessed as a predictor of cardiovascular events from 6 to 36 months using a Cox proportional hazard regression model. Results: As of March 1, 2022, 3,077 patients were enrolled: 42.2% were female; mean age was 60.5 ± 12.2 years; baseline OSBP was 165.6 ± 24.8 mm Hg; and baseline ASBP was 154.3 ± 18.7 mm Hg. Patients were prescribed 4.9 ± 1.7 antihypertensive medications at baseline and 4.8 ± 1.9 at 36 months. At 36 months, mean changes were −16.7 ± 28.4 and −9.0 ± 20.2 mm Hg for OSBP and ASBP, respectively. TTR through 6 months was 30.6%. A 10% increase in TTR after RDN through 6 months was associated with significant risk reductions from 6 to 36 months of 15% for major adverse cardiovascular events (P < 0.001), 11% cardiovascular death (P = 0.010), 15% myocardial infarction (P = 0.023), and 23% stroke (P < 0.001). Conclusions: There were sustained BP reductions and higher TTR through 36 months after RDN. A 10% increase in TTR through 6 months was associated with significant risk reductions in major cardiovascular events from 6 to 36 months. (Global SYMPLICITY Registry [GSR] DEFINE; NCT01534299)
Published: 2022

10. Renal denervation in patients with versus without chronic kidney disease: Results from the Global SYMPLICITY Registry with follow-up data of 3 years

Author: Ott, C, Mahfoud, F, Mancia, G, Narkiewicz, K, Ruilope, L, Fahy, M, Schlaich, M, Bohm, M, Schmieder, R, Ott C., Mahfoud F., Mancia G., Narkiewicz K., Ruilope L. M., Fahy M., Schlaich M. P., Bohm M., Schmieder R. E., Ott, C, Mahfoud, F, Mancia, G, Narkiewicz, K, Ruilope, L, Fahy, M, Schlaich, M, Bohm, M, Schmieder, R, Ott C., Mahfoud F., Mancia G., Narkiewicz K., Ruilope L. M., Fahy M., Schlaich M. P., Bohm M., and Schmieder R. E.
Abstract: Background: Activity of the sympathetic nervous system is increased in patients with hypertension and chronic kidney disease (CKD). Here we compare short-and long-term blood pressure (BP)-lowering effects of renal denervation (RDN) between hypertensive patients with or without CKD in the Global SYMPLICITY Registry. Methods: Office and 24-h ambulatory BP (ABP) were assessed at prespecified time points after RDN. The presence of CKD was defined according to the estimated glomerular filtration rate (eGFR) and enrolled patients were stratified based on the presence (n = 475, eGFR <60 mL/min/1.73 m2) or absence (n = 1505, eGFR ≥60mL/min/1.73 m2) of CKD. Results: Patients with CKD were older (P < 0.001) and were prescribed more antihypertensive medications (P < 0.001). eGFR decline per year was not significantly different between groups after the first year. Office and 24-h ABP were significantly reduced from baseline at all time points after RDN in both groups (all P < 0.001). After adjusting for baseline data, patients without CKD had a greater reduction in office systolic BP (-17.3 ± 28.3 versus-11.7 ± 29.9 mmHg; P = 0.009) but not diastolic BP at 36 months compared with those with CKD. Similar BP and eGFR results were found when the analysis was limited to patients with both baseline and 36-month BP data available. There was no difference in the safety profile of the RDN procedure between groups. Conclusions: After adjusting for baseline data, 24-h systolic and diastolic ABP reduction were similar in patients with and without CKD after RDN, whereas office systolic but not diastolic BP was reduced less in patients with CKD. We conclude that RDN is an effective antihypertensive treatment option in CKD patients.
Published: 2022

11. IDF2022-1255 Efficacy and safety of finerenone by age and sex subgroups in patients with chronic kidney disease and type 2 diabetes

Author: Bansal, S., primary, Anker, S., additional, Bakris, G., additional, Filippatos, G., additional, Rossing, P., additional, Ruilope, L., additional, Birne, R., additional, Canziani, M., additional, Farjat, A., additional, Brinker, M., additional, and Pitt, B., additional
Published: 2023
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12. Clinical event reductions in high-risk patients after renal denervation projected from the global SYMPLICITY registry

Author: Schmieder, R, Mahfoud, F, Mancia, G, Narkiewicz, K, Ruilope, L, Hutton, D, Cao, K, Hettrick, D, Fahy, M, Schlaich, M, Böhm, M, Pietzsch, J, Schmieder, RE, Hettrick, DA, Schlaich, MP, Pietzsch, JB, Schmieder, R, Mahfoud, F, Mancia, G, Narkiewicz, K, Ruilope, L, Hutton, D, Cao, K, Hettrick, D, Fahy, M, Schlaich, M, Böhm, M, Pietzsch, J, Schmieder, RE, Hettrick, DA, Schlaich, MP, and Pietzsch, JB
Abstract: Aims: Renal denervation has been shown to lower blood pressure in sham-controlled trials and represents a device-based treatment option for hypertension. We sought to project clinical event reductions after radiofrequency renal denervation using a novel modelling approach. Methods and results: The Global SYMPLICITY Registry is a global, prospective all-comer registry to evaluate safety and efficacy after renal denervation. For this analysis, change in office systolic blood pressure from baseline was calculated from reported follow-up in the Global SYMPLICITY Registry. Relative risks for death and other cardiovascular events as well as numbers needed to treat for event avoidance were obtained for the respective blood pressure reductions based on previously reported meta-regression analyses for the full cohort and high-risk subgroups including type 2 diabetes, chronic kidney disease, resistant hypertension, and high basal cardiovascular risk. Average baseline office systolic blood pressure and reduction estimates for the full cohort (N = 2651) were 166±25 and -14.8 ± 0.4 mmHg, respectively. Mean reductions in blood pressure ranged from -11.0 - 21.8 mmHg for the studied high-risk subgroups. Projected relative risks ranged from 0.57 for stroke in the resistant hypertension cohort to 0.92 for death in the diabetes cohort. Significant absolute reductions in major adverse cardiovascular events over 3 years compared with the projected control (8.6 ± 0.7% observed vs. 11.7 ± 0.9% for projected control; P < 0.01) were primarily due to reduced stroke incidence. The robustness of findings was confirmed in sensitivity and scenario analyses. Conclusion: Model-based projections suggest radiofrequency renal denervation for patients with uncontrolled hypertension adds considerable clinical benefit across a spectrum of different cohort characteristics.
Published: 2023

13. Long-Term Safety and Efficacy of Renal Denervation in the Global Symplicity Registry Using the Symplicity Spyral Catheter

Author: Wang, T, Schlaich, M, Mahfoud, F, Wiliams, B, Ruilope, L, Narkiewicz, K, Fahy, M, Mancia, G, Böhm, M, Wang, TD, Wang, T, Schlaich, M, Mahfoud, F, Wiliams, B, Ruilope, L, Narkiewicz, K, Fahy, M, Mancia, G, Böhm, M, and Wang, TD
Published: 2023

14. In patients with type 2 diabetes chronic kidney disease is a modifiable cardiovascular risk factor

Author: Agarwal, R, primary, Pitt, B, additional, Rossing, P, additional, Anker, S D, additional, Filippatos, G, additional, Ruilope, L M, additional, Kovesdy, C P, additional, Tuttle, K, additional, Vaduganathan, M, additional, Wanner, C, additional, Bansilal, S, additional, Gebel, M, additional, Joseph, A, additional, Lawatscheck, R, additional, and Bakris, G, additional
Published: 2022
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15. Blood pressure reduction in higher cardiovascular risk patients in the Global SYMPLICITY Registry

Author: Rodriguez, O, primary, Mahfoud, F, additional, Schmieder, R, additional, Schlaich, M, additional, Narkiewicz, K, additional, Ruilope, L, additional, Williams, B, additional, Fahy, M, additional, Mancia, G, additional, and Boehm, M, additional
Published: 2022
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16. A COMPARISON BETWEEN USUAL OFFICE AND FOUR OTHER METHODS TO EVALUATE BLOOD PRESSURE (BP-TRUE, HBPM, ABPM AND CBP) DURING 3 YEARS FOLLOW-UP

Author: Ruilope, L.-M., Brotons, C., Quevedo-Aguado, L., Segura, J., Martinez, P., Ruiz-Hurtado, G., Moral, I., and Calvo-Bonacho, E.
Published: 2018
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17. Modification over time of pulse wave velocity parallel to changes in aortic BP, as well as in 24-h ambulatory brachial BP

Author: Oliveras, A, Segura, J, Suarez, C, García-Ortiz, L, Abad-Cardiel, M, Vigil, L, Gómez-Marcos, M A, Sans Atxer, L, Martell-Claros, N, Ruilope, L M, and de la Sierra, A
Published: 2016
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18. Renal Denervation in High-Risk Patients With Hypertension

Author: Mahfoud, F, Mancia, G, Schmieder, R, Narkiewicz, K, Ruilope, L, Schlaich, M, Whitbourn, R, Zirlik, A, Zeller, T, Stawowy, P, Cohen, S, Fahy, M, Bohm, M, Mahfoud F., Mancia G., Schmieder R., Narkiewicz K., Ruilope L., Schlaich M., Whitbourn R., Zirlik A., Zeller T., Stawowy P., Cohen S. A., Fahy M., Bohm M., Mahfoud, F, Mancia, G, Schmieder, R, Narkiewicz, K, Ruilope, L, Schlaich, M, Whitbourn, R, Zirlik, A, Zeller, T, Stawowy, P, Cohen, S, Fahy, M, Bohm, M, Mahfoud F., Mancia G., Schmieder R., Narkiewicz K., Ruilope L., Schlaich M., Whitbourn R., Zirlik A., Zeller T., Stawowy P., Cohen S. A., Fahy M., and Bohm M.
Abstract: Background: Renal denervation (RDN) is under investigation for treatment of uncontrolled hypertension and might represent an attractive treatment for patients with high cardiovascular (CV) risk. It is important to determine whether baseline CV risk affects the efficacy of RDN. Objectives: The purpose of this study was to assess blood pressure (BP) reduction and event rates after RDN in patients with various comorbidities, testing the hypothesis that RDN is effective and durable in these high-risk populations. Methods: BP reduction and adverse events over 3 years were evaluated for several high-risk subgroups in the GSR (Global proSpective registrY for syMPathetic renaL denervatIon in seleCted IndicatIons Through 3 Years Registry), an international registry of RDN in patients with uncontrolled hypertension (n = 2,652). Comparisons were made for patients age ≥65 years versus age <65 years, with versus without isolated systolic hypertension, with versus without atrial fibrillation, and with versus without diabetes mellitus. Baseline cardiovascular risk was estimated using the American Heart Association (AHA)/American College of Cardiology (ACC) atherosclerosis cardiovascular disease (ASCVD) risk score. Results: Reduction in 24-h systolic BP at 3 years was −8.9 ± 20.1 mm Hg for the overall cohort, and for high-risk subgroups, BP reduction was −10.4 ± 21.0 mm Hg for resistant hypertension, −8.7 ± 17.4 mm Hg in patients age ≥65 years, −10.2 ± 17.9 mm Hg in patients with diabetes, −8.6 ± 18.7 mm Hg in isolated systolic hypertension, −10.1 ± 20.3 mm Hg in chronic kidney disease, and −10.0 ± 19.1 mm Hg in atrial fibrillation (p < 0.0001 compared with baseline for all). BP reduction in patients with measurements at 6, 12, 24, and 36 months showed similar reductions in office and 24-h BP for patients with varying baseline ASCVD risk scores, which was sustained to 3 years. Adverse event rates at 3 years were higher for patients with higher baseline CV risk. Conclusions: B
Published: 2020

19. Blood Pressure Reduction After Catheter-based Renal Denervation in Patients with Cardiovascular Disease in the Global Symplicity Registry

Author: Mahfoud, F, Schmieder, R, Schlaich, M, Narkiewicz, K, Ruilope, L, Williams, B, Fahy, M, Mancia, G, Bohm, M, Mahfoud, F, Schmieder, R, Schlaich, M, Narkiewicz, K, Ruilope, L, Williams, B, Fahy, M, Mancia, G, and Bohm, M
Published: 2022

20. Blood pressure reduction after catheter-based radiofrequency renal denervation in the Global SYMPLICITY Registry

Author: Sharif, F, Schlaich, M, Mahfoud, F, Williams, B, Ruilope, L, Narkiewicz, K, Fahy, M, Mancia, G, Böhm, M, Sharif, F, Schlaich, M, Mahfoud, F, Williams, B, Ruilope, L, Narkiewicz, K, Fahy, M, Mancia, G, and Böhm, M
Published: 2022

21. Reduction of Clinical Events in High-Risk Hypertension Patients Treated With Renal Denervation: A Modeled Estimate From 36-Month Global SYMPLICTY Registry Data

Author: Schlaich, M, Pietzsch, J, Mahfoud, F, Wiliams, B, Mancia, G, Narkiewicz, K, Ruilope, L, Hettrick, D, Böhm, M, Schmieder, R, Pietzsch, JB, Schmieder, RE, Schlaich, M, Pietzsch, J, Mahfoud, F, Wiliams, B, Mancia, G, Narkiewicz, K, Ruilope, L, Hettrick, D, Böhm, M, Schmieder, R, Pietzsch, JB, and Schmieder, RE
Published: 2022

22. New approach to measurement of blood pressure in the office

Author: Myers, M.G. and Ruilope, L.
Published: 2012
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23. Heart rate and heart rate variability in resistant versus controlled hypertension and in true versus white-coat resistance

Author: de la Sierra, A, Calhoun, D A, Vinyoles, E, Banegas, J R, de la Cruz, J J, Gorostidi, M, Segura, J, and Ruilope, L M
Published: 2014
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24. Interpreting treatment-induced blood pressure reductions measured by ambulatory blood pressure monitoring

Author: Schmieder, R E, Ruilope, L M, Ott, C, Mahfoud, F, and Böhm, M
Published: 2013
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25. Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry

Author: Mahfoud, F, Bohm, M, Schmieder, R, Narkiewicz, K, Ewen, S, Ruilope, L, Schlaich, M, Williams, B, Fahy, M, Mancia, G, Mahfoud F., Bohm M., Schmieder R., Narkiewicz K., Ewen S., Ruilope L., Schlaich M., Williams B., Fahy M., Mancia G., Mahfoud, F, Bohm, M, Schmieder, R, Narkiewicz, K, Ewen, S, Ruilope, L, Schlaich, M, Williams, B, Fahy, M, Mancia, G, Mahfoud F., Bohm M., Schmieder R., Narkiewicz K., Ewen S., Ruilope L., Schlaich M., Williams B., Fahy M., and Mancia G.
Abstract: Aims: Several studies and registries have demonstrated sustained reductions in blood pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in real-world patients with uncontrolled hypertension, however, remains unknown. The objective of this study was to assess the long-term safety and efficacy of RDN, including its effects on renal function. Methods and results: The Global SYMPLICITY Registry is a prospective, open-label registry conducted at 196 active sites worldwide in hypertensive patients receiving RDN treatment. Among 2237 patients enrolled and treated with the SYMPLICITY Flex catheter, 1742 were eligible for follow-up at 3 years. Baseline office and 24-h ambulatory systolic BP (SBP) were 166 ± 25 and 154 ± 18 mmHg, respectively. SBP reduction after RDN was sustained over 3 years, including decreases in both office (-16.5 ± 28.6 mmHg, P < 0.001) and 24-h ambulatory SBP (-8.0 ± 20.0 mmHg; P < 0.001). Twenty-one percent of patients had a baseline estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Between baseline and 3 years, renal function declined by 7.1 mL/min/1.73 m2 in patients without chronic kidney disease (CKD; eGFR ≥60 mL/min/1.73 m2; baseline eGFR 87 ± 17 mL/min/1.73 m2) and by 3.7 mL/min/1.73 m2 in patients with CKD (eGFR <60 mL/min/1.73 m2; baseline eGFR 47 ± 11 mL/min/1.73 m2). No long-term safety concerns were observed following the RDN procedure. Conclusion: Long-term data from the Global SYMPLICITY Registry representing the largest available cohort of hypertensive patients receiving RDN in a real-world clinical setting demonstrate both the safety and efficacy of the procedure with significant and sustained office and ambulatory BP reductions out to 3 years.
Published: 2019

26. Ghidul ESC/ESH 2018 pentru managementul hipertensiunii arteriale

Author: Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, de Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., de Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, de Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., de Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., and Desormais I.
Published: 2019

27. Wytyczne ESC/ESH dotyczace postȩpowania w nadciśnieniu tȩtniczym (2018): Grupa Robocza Europejskiego Towarzystwa Kardiologicznego (ESC) i Europejskiego Towarzystwa Nadciśnienia Tȩtniczego (ESH) do spraw postȩpowania w nadciśnieniu tȩtniczym

Author: Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Windecker, S, Agewall, S, Barbato, E, Bueno, H, Collet, J, Coman, I, Dean, V, Delgado, V, Fitzsimons, D, Gaemperli, O, Hindricks, G, Iung, B, Juni, P, Katus, H, Knuuti, J, Lancellotti, P, Leclercq, C, Mcdonagh, T, Piepoli, M, Ponikowski, P, Richter, D, Roffi, M, Simpson, I, Sousa-Uva, M, Zamorano, J, Lurbe, E, Bochud, M, Jelakovic, B, Januszewicz, A, Polonia, J, Van De Borne, P, Borghi, C, Parati, G, Manolis, A, Lovic, D, Benkhedda, S, Zelveian, P, Siostrzonek, P, Najafov, R, Pavlova, O, De Pauw, M, Dizdarevic-Hudic, L, Raev, D, Karpettas, N, Olsen, M, Shaker, A, Viigimaa, M, Baranova, E, Metsarinne, K, Halimi, J, Pagava, Z, Thomopoulos, C, Bertomeu-Martinez, V, Wittekoek, J, Andersen, K, Shechter, M, Romanova, T, Bajraktari, G, Saade, G, Sakalyte, G, Noppe, S, Trusinskis, K, Vavlukis, M, Demarco, D, Caraus, A, Schunkert, H, Aksnes, T, Jankowski, P, Linhart, A, Vinereanu, D, Foscoli, M, Dikic, A, Filipova, S, Fras, Z, Burkard, T, Carlberg, B, Sdiri, W, Aydogdu, S, Sirenko, Y, Pall, D, Brady, A, Mercuro, G, Weber, T, Lazareva, I, De Backer, T, Sokolovic, S, Chazova, I, Porsti, I, Denolle, T, Stergiou, G, Segura, J, Miglinas, M, Kramer, B, Gerdts, E, Tykarski, A, De Carvalho Rodrigues, M, Widimsky, J, Dorobantu, M, Brguljan, J, Pechere-Bertschi, A, Gottsater, A, Erdine, S, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., Windecker S., Agewall S., Barbato E., Bueno H., Collet J. -P., Coman I. M., Dean V., Delgado V., Fitzsimons D., Gaemperli O., Hindricks G., Iung B., Juni P., Katus H. A., Knuuti J., Lancellotti P., Leclercq C., McDonagh T. A., Piepoli M. F., Ponikowski P., Richter D. J., Roffi M., Simpson I. A., Sousa-Uva M., Zamorano J. L., Lurbe E., Bochud M., Jelakovic B., Januszewicz A., Polonia J., Van De Borne P., Borghi C., Parati G., Manolis A., Lovic D., Benkhedda S., Zelveian P., Siostrzonek P., Najafov R., Pavlova O., De Pauw M., Dizdarevic-Hudic L., Raev D., Karpettas N., Olsen M. H., Shaker A. F., Viigimaa M., Baranova E. I., Metsarinne K., Halimi J. -M., Pagava Z., Thomopoulos C., Bertomeu-Martinez V., Wittekoek J., Andersen K., Shechter M., Romanova T., Bajraktari G., Saade G. A., Sakalyte G., Noppe S., Trusinskis K., Vavlukis M., DeMarco D. C., Caraus A., Schunkert H., Aksnes T. A., Jankowski P., Linhart A., Vinereanu D., Foscoli M., Dikic A. D., Filipova S., Fras Z., Burkard T., Carlberg B., Sdiri W., Aydogdu S., Sirenko Y., Pall D., Brady A., Mercuro G., Weber T., Lazareva I., De Backer T., Sokolovic S., Chazova I., Porsti I., Denolle T., Stergiou G. S., Segura J., Miglinas M., Kramer B. K., Gerdts E., Tykarski A., De Carvalho Rodrigues M., Widimsky J., Dorobantu M., Brguljan J., Pechere-Bertschi A., Gottsater A., Erdine S., Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Windecker, S, Agewall, S, Barbato, E, Bueno, H, Collet, J, Coman, I, Dean, V, Delgado, V, Fitzsimons, D, Gaemperli, O, Hindricks, G, Iung, B, Juni, P, Katus, H, Knuuti, J, Lancellotti, P, Leclercq, C, Mcdonagh, T, Piepoli, M, Ponikowski, P, Richter, D, Roffi, M, Simpson, I, Sousa-Uva, M, Zamorano, J, Lurbe, E, Bochud, M, Jelakovic, B, Januszewicz, A, Polonia, J, Van De Borne, P, Borghi, C, Parati, G, Manolis, A, Lovic, D, Benkhedda, S, Zelveian, P, Siostrzonek, P, Najafov, R, Pavlova, O, De Pauw, M, Dizdarevic-Hudic, L, Raev, D, Karpettas, N, Olsen, M, Shaker, A, Viigimaa, M, Baranova, E, Metsarinne, K, Halimi, J, Pagava, Z, Thomopoulos, C, Bertomeu-Martinez, V, Wittekoek, J, Andersen, K, Shechter, M, Romanova, T, Bajraktari, G, Saade, G, Sakalyte, G, Noppe, S, Trusinskis, K, Vavlukis, M, Demarco, D, Caraus, A, Schunkert, H, Aksnes, T, Jankowski, P, Linhart, A, Vinereanu, D, Foscoli, M, Dikic, A, Filipova, S, Fras, Z, Burkard, T, Carlberg, B, Sdiri, W, Aydogdu, S, Sirenko, Y, Pall, D, Brady, A, Mercuro, G, Weber, T, Lazareva, I, De Backer, T, Sokolovic, S, Chazova, I, Porsti, I, Denolle, T, Stergiou, G, Segura, J, Miglinas, M, Kramer, B, Gerdts, E, Tykarski, A, De Carvalho Rodrigues, M, Widimsky, J, Dorobantu, M, Brguljan, J, Pechere-Bertschi, A, Gottsater, A, Erdine, S, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., Windecker S., Agewall S., Barbato E., Bueno H., Collet J. -P., Coman I. M., Dean V., Delgado V., Fitzsimons D., Gaemperli O., Hindricks G., Iung B., Juni P., Katus H. A., Knuuti J., Lancellotti P., Leclercq C., McDonagh T. A., Piepoli M. F., Ponikowski P., Richter D. J., Roffi M., Simpson I. A., Sousa-Uva M., Zamorano J. L., Lurbe E., Bochud M., Jelakovic B., Januszewicz A., Polonia J., Van De Borne P., Borghi C., Parati G., Manolis A., Lovic D., Benkhedda S., Zelveian P., Siostrzonek P., Najafov R., Pavlova O., De Pauw M., Dizdarevic-Hudic L., Raev D., Karpettas N., Olsen M. H., Shaker A. F., Viigimaa M., Baranova E. I., Metsarinne K., Halimi J. -M., Pagava Z., Thomopoulos C., Bertomeu-Martinez V., Wittekoek J., Andersen K., Shechter M., Romanova T., Bajraktari G., Saade G. A., Sakalyte G., Noppe S., Trusinskis K., Vavlukis M., DeMarco D. C., Caraus A., Schunkert H., Aksnes T. A., Jankowski P., Linhart A., Vinereanu D., Foscoli M., Dikic A. D., Filipova S., Fras Z., Burkard T., Carlberg B., Sdiri W., Aydogdu S., Sirenko Y., Pall D., Brady A., Mercuro G., Weber T., Lazareva I., De Backer T., Sokolovic S., Chazova I., Porsti I., Denolle T., Stergiou G. S., Segura J., Miglinas M., Kramer B. K., Gerdts E., Tykarski A., De Carvalho Rodrigues M., Widimsky J., Dorobantu M., Brguljan J., Pechere-Bertschi A., Gottsater A., and Erdine S.
Published: 2019

28. Application of win ratio methodology in the Global SYMPLICITY Registry for patients with atrial fibrillation or obstructive sleep apnea

Author: Mahfoud, F, primary, Mancia, G, additional, Ukena, C, additional, Schmieder, R, additional, Narkiewicz, K, additional, Ruilope, L, additional, Schlaich, M, additional, Williams, B, additional, Fahy, M, additional, and Boehm, M, additional
Published: 2021
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29. CLINICAL EVENT REDUCTIONS IN HIGH-RISK HYPERTENSION PATIENTS TREATED WITH RENAL DENERVATION: A MODEL-BASED ESTIMATE BASED ON 36-MONTH DATA FROM THE GLOBAL SYMPLICITY REGISTRY

Author: Pietzsch, J, Mahfoud, F, Williams, B, Mancia, G, Narkiewicz, K, Ruilope, L, Schlaich, M, Hettrick, D, Boehm, M, Schmieder, R, Pietzsch, J, Mahfoud, F, Williams, B, Mancia, G, Narkiewicz, K, Ruilope, L, Schlaich, M, Hettrick, D, Boehm, M, and Schmieder, R
Published: 2021

30. Joint association of physical activity and body mass index with cardiovascular risk: a nationwide population-based cross-sectional study

Author: Valenzuela, P. L., Santos-Lozano, A., Barrán, A. T., Fernández-Navarro, Pablo, Castillo-García, A., Ruilope, L. M., Ríos Insua, David, Ordovás, José M., Ley, Victoria, Lucia, Alejandro, Valenzuela, P. L., Santos-Lozano, A., Barrán, A. T., Fernández-Navarro, Pablo, Castillo-García, A., Ruilope, L. M., Ríos Insua, David, Ordovás, José M., Ley, Victoria, and Lucia, Alejandro
Published: 2021

31. Association between physical activity and cardiovascular risk factors: dose and sex matter

Author: Ministerio de Economía y Competitividad (España), European Commission, Santos-Lozano, A., Barrán, A.T., Fernández-Navarro, Pablo, Valenzuela, P.L., Castillo-Garcia, A., Ruilope, L. M., Ríos Insua, David, Ordovás, José M., Ley, Victoria, Lucía, A., Ministerio de Economía y Competitividad (España), European Commission, Santos-Lozano, A., Barrán, A.T., Fernández-Navarro, Pablo, Valenzuela, P.L., Castillo-Garcia, A., Ruilope, L. M., Ríos Insua, David, Ordovás, José M., Ley, Victoria, and Lucía, A.
Abstract: descripción no proporcionada por scopus
Published: 2021

32. Office and ambulatory pulse pressure—association with clinical characteristics and cardiovascular risk factors in normoalbuminuric patients with type 2 diabetes (ROADMAP study)

Author: Januszewicz, A, Ritz, E, Viberti, G, Mimran, A, Rabelink, A J, Rump, L C, Ruilope, L M, Katayama, S, Ito, S, Izzo, Jr, J L, and Haller, H
Published: 2011
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33. European Society of Hypertension Practice Guidelines for home blood pressure monitoring

Author: Parati, G, Stergiou, G S, Asmar, R, Bilo, G, de Leeuw, P, Imai, Y, Kario, K, Lurbe, E, Manolis, A, Mengden, T, O'Brien, E, Ohkubo, T, Padfield, P, Palatini, P, Pickering, T G, Redon, J, Revera, M, Ruilope, L M, Shennan, A, Staessen, J A, Tisler, A, Waeber, B, Zanchetti, A, and Mancia, G
Published: 2010
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34. Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study

Author: Ritz, E., Viberti, G. C., Ruilope, L. M., Rabelink, A. J., Izzo, Jr, J. L., Katayama, S., Ito, S., Mimran, A., Menne, J., Rump, L. C., Januszewicz, A., and Haller, H.
Published: 2010
Full Text: View/download PDF

35. Decision Terapeutica Basada en Hemodinamia no Invasiva (Hotman®) en Hipertensos no Controlados: 0290

Author: Márquez, D., Cerezo, C., Romero, C., Fernandez, L., Guerrero, L., Ruilope, L M., and Segura, J.
Published: 2014

36. ¿Influye el Fenotipo del Paciente Hipertenso a la Hora de Elegir la Mejor Combinacion de dos Farmacos Antihipertensivos?: 0293

Author: Márquez, D., Cerezo, C., Sevillano, A., Fernandez, L., Guerrero, L., Praga, M., Ruilope, L M., and Segura, J.
Published: 2014

37. Wytyczne ESC/ESH dotyczace postȩpowania w nadciśnieniu tȩtniczym (2018): Grupa Robocza Europejskiego Towarzystwa Kardiologicznego (ESC) i Europejskiego Towarzystwa Nadciśnienia Tȩtniczego (ESH) do spraw postȩpowania w nadciśnieniu tȩtniczym

Author: Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., Windecker S., Agewall S., Barbato E., Bueno H., Collet J. -P., Coman I. M., Dean V., Delgado V., Fitzsimons D., Gaemperli O., Hindricks G., Iung B., Juni P., Katus H. A., Knuuti J., Lancellotti P., Leclercq C., McDonagh T. A., Piepoli M. F., Ponikowski P., Richter D. J., Roffi M., Simpson I. A., Sousa-Uva M., Zamorano J. L., Lurbe E., Bochud M., Jelakovic B., Januszewicz A., Polonia J., Van De Borne P., Borghi C., Parati G., Manolis A., Lovic D., Benkhedda S., Zelveian P., Siostrzonek P., Najafov R., Pavlova O., De Pauw M., Dizdarevic-Hudic L., Raev D., Karpettas N., Olsen M. H., Shaker A. F., Viigimaa M., Baranova E. I., Metsarinne K., Halimi J. -M., Pagava Z., Thomopoulos C., Bertomeu-Martinez V., Wittekoek J., Andersen K., Shechter M., Romanova T., Bajraktari G., Saade G. A., Sakalyte G., Noppe S., Trusinskis K., Vavlukis M., DeMarco D. C., Caraus A., Schunkert H., Aksnes T. A., Jankowski P., Linhart A., Vinereanu D., Foscoli M., Dikic A. D., Filipova S., Fras Z., Burkard T., Carlberg B., Sdiri W., Aydogdu S., Sirenko Y., Pall D., Brady A., Mercuro G., Weber T., Lazareva I., De Backer T., Sokolovic S., Chazova I., Porsti I., Denolle T., Stergiou G. S., Segura J., Miglinas M., Kramer B. K., Gerdts E., Tykarski A., De Carvalho Rodrigues M., Widimsky J., Dorobantu M., Brguljan J., Pechere-Bertschi A., Gottsater A., Erdine S., Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Windecker, S, Agewall, S, Barbato, E, Bueno, H, Collet, J, Coman, I, Dean, V, Delgado, V, Fitzsimons, D, Gaemperli, O, Hindricks, G, Iung, B, Juni, P, Katus, H, Knuuti, J, Lancellotti, P, Leclercq, C, Mcdonagh, T, Piepoli, M, Ponikowski, P, Richter, D, Roffi, M, Simpson, I, Sousa-Uva, M, Zamorano, J, Lurbe, E, Bochud, M, Jelakovic, B, Januszewicz, A, Polonia, J, Van De Borne, P, Borghi, C, Parati, G, Manolis, A, Lovic, D, Benkhedda, S, Zelveian, P, Siostrzonek, P, Najafov, R, Pavlova, O, De Pauw, M, Dizdarevic-Hudic, L, Raev, D, Karpettas, N, Olsen, M, Shaker, A, Viigimaa, M, Baranova, E, Metsarinne, K, Halimi, J, Pagava, Z, Thomopoulos, C, Bertomeu-Martinez, V, Wittekoek, J, Andersen, K, Shechter, M, Romanova, T, Bajraktari, G, Saade, G, Sakalyte, G, Noppe, S, Trusinskis, K, Vavlukis, M, Demarco, D, Caraus, A, Schunkert, H, Aksnes, T, Jankowski, P, Linhart, A, Vinereanu, D, Foscoli, M, Dikic, A, Filipova, S, Fras, Z, Burkard, T, Carlberg, B, Sdiri, W, Aydogdu, S, Sirenko, Y, Pall, D, Brady, A, Mercuro, G, Weber, T, Lazareva, I, De Backer, T, Sokolovic, S, Chazova, I, Porsti, I, Denolle, T, Stergiou, G, Segura, J, Miglinas, M, Kramer, B, Gerdts, E, Tykarski, A, De Carvalho Rodrigues, M, Widimsky, J, Dorobantu, M, Brguljan, J, Pechere-Bertschi, A, Gottsater, A, and Erdine, S
Subjects: Antihypertensive Agent, Cardiology, Disease Management
Published: 2019

38. Achieving blood pressure goals globally: five core actions for health-care professionals. A worldwide call to action

Author: Bakris, G, Hill, M, Mancia, G, Steyn, K, Black, H R, Pickering, T, De Geest, S, Ruilope, L, Giles, T D, Morgan, T, Kjeldsen, S, Schiffrin, E L, Coenen, A, Mulrow, P, Loh, A, and Mensah, G
Published: 2008
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39. May Measurement Month 2017: an analysis of blood pressure screening results worldwide

Author: Beaney, T, Schutte, A, Tomaszewski, M, Ariti, C, Burrell, L, Castillo, R, Charchar, F, Damasceno, A, Kruger, R, Lackland, D, Nilsson, P, Prabhakaran, D, Ramirez, A, Schlaich, M, Wang, J, Weber, M, Poulter, N, Napiza-Granada, C, Sevilla, M, Atilano, A, Ona, D, More, A, Jose, A, Maheshwari, A, Kondal, D, Yu, W, Li, W, Xu, S, Yu, J, Zhang, H, Widyantoro, B, Turana, Y, Situmorang, T, Sofiatin, Y, Barack, R, Lin, H, Wang, T, Chen, W, Sirenko, Y, Evstigneeva, O, Negresku, E, Yousif, M, Medani, S, Beheiry, H, Ali, I, Zilberman, J, Marin, M, Rodriguez, P, Garcia-Vasquez, F, Kramoh, K, Ekoua, D, Lopez-Jaramillo, P, Otero, J, Sanchez, G, Narvaez, C, Accini, J, Hernandez-Hernandez, R, Octavio, J, Morr, I, Lopez-Rivera, J, Ojji, D, Arije, A, Babatunte, A, Wahab, K, REIS FERNANDES, M, Pereira, S, Valentim, M, Dzudie, A, Kingue, S, Djomou Ngongang, D, Ogola, E, Barasa, F, Gitura, B, Malik, F, Choudhury, S, Al Mamun, M, Minh, V, Viet, N, Cao Truong, S, Ferri, C, Parati, G, Torlasco, C, Borghi, C, Goma, F, Syatalimi, C, Zelveian, P, Barbosa, E, Sebba Barroso, W, Penaherrera, E, Jarrin, E, Yusufali, A, Bazargani, N, Tsinamdzgvrishvili, B, Trapaidze, D, Neupane, D, Mishra, S, Jozwiak, J, Malyszko, J, Konradi, A, Chazova, I, Ishaq, M, Memon, F, Heagerty, A, Keitley, J, Brady, A, Cockcroft, J, Mcdonnell, B, Lanas, F, Chia, Y, Ndhlovu, H, Kiss, I, Ruilope, L, Ellenga Mbolla, B, Milhailidou, A, Woodiwiss, A, Perl, S, Dolan, E, Azevedo, V, Garre, L, Boggia, J, Lee, V, Kowlessur, S, Miglinas, M, Sukackiene, D, Wainford, R, Habonimana, D, Masupe, T, Ortellado, J, Wuerzner, G, Alcocer, L, Burazeri, G, Sanchez Delgado, E, Lovic, D, Mondo, C, Mostafa, A, Nadar, S, Valdez Tiburcio, O, Leiba, A, Dorobantu, M, De Backer, T, Chifamba, J, Stergiou, G, Nwokocha, C, Sokolovic, S, Toure, A, Connell, K, Khan, N, Burger, D, De Carvalho Rodrigues, M, Kramer, B, Schmieder, R, Unger, T, Wyss, F, Yameogo, N, Beistline, H, Kenerson, J, Alfonso, B, Olsen, M, Soares, M, Beaney, Thomas, Schutte, Aletta E, Tomaszewski, Maciej, Ariti, Cono, Burrell, Louise M, Castillo, Rafael R, Charchar, Fadi J, Damasceno, Albertino, Kruger, Ruan, Lackland, Daniel T, Nilsson, Peter M, Prabhakaran, Dorairaj, Ramirez, Agustin J, Schlaich, Markus P, Wang, Jiguang, Weber, Michael A, Poulter, Neil R, Napiza-Granada, C., Sevilla, Ma. RC, Atilano, A. A., Ona, D. I. D., More, A., Jose, A. P., Maheshwari, A., Kondal, D., Yu, W., Li, W., Xu, S., Yu, J., Zhang, H., Widyantoro, B., Turana, Y., Situmorang, T. D., Sofiatin, Y., Barack, R., Lin, H. -J., Wang, T. -D., Chen, W. -J., Sirenko, Y., Evstigneeva, O., Negresku, E., Yousif, M. E., Medani, S. A., Beheiry, H. M., Ali, I. A., Zilberman, J. M., Marin, M. J., Rodriguez, P. D., Garcia-Vasquez, F., Kramoh, K. E., Ekoua, D., Lopez-Jaramillo, P., Otero, J., Sanchez, G., Narvaez, C., Accini, J. L., Hernandez-Hernandez, R., Octavio, J. A., Morr, I., Lopez-Rivera, J., Ojji, D., Arije, A., Babatunte, A., Wahab, K. W., REIS FERNANDES, MARCOS ANTONIO, Pereira, S. V., Valentim, M., Dzudie, A., Kingue, S., Djomou Ngongang, D. A., Ogola, E. N., Barasa, F. A., Gitura, B., Malik, F-T-N, Choudhury, S. R., Al Mamun, M. A., Minh, V. H., Viet, N. L., Cao Truong, S., Ferri, C., Parati, G., Torlasco, C., Borghi, C., Goma, F. M., Syatalimi, C., Zelveian, P. H., Barbosa, E., Sebba Barroso, W., Penaherrera, E., Jarrin, E., Yusufali, A., Bazargani, N., Tsinamdzgvrishvili, B., Trapaidze, D., Neupane, D., Mishra, S. R., Jozwiak, J., Malyszko, J., Konradi, A., Chazova, I., Ishaq, M., Memon, F., Heagerty, A. M., Keitley, J., Brady, A. J. B., Cockcroft, J. R., McDonnell, B. J., Lanas, F., Chia, Y. -C., Ndhlovu, H., Kiss, I., Ruilope, L. M., Ellenga Mbolla, B. F., Milhailidou, A. S., Woodiwiss, A. J., Perl, S., Dolan, E., Azevedo, V., Garre, L., Boggia, J. G., Lee, V. W. Y., Kowlessur, S., Miglinas, M., Sukackiene, D., Wainford, R. D., Habonimana, D., Masupe, T., Ortellado, J., Wuerzner, G., Alcocer, L., Burazeri, G., Sanchez Delgado, E., Lovic, D., Mondo, C. K., Mostafa, A., Nadar, S. K., Valdez Tiburcio, O., Leiba, A., Dorobantu, M., De Backer, T., Chifamba, J., Stergiou, G., Nwokocha, C. R., Sokolovic, S., Toure, A. I., Connell, K. L., Khan, N. A., Burger, D., De Carvalho Rodrigues, M., Kramer, B. K., Schmieder, R. E., Unger, T., Wyss, F. S., Yameogo, N. V., Beistline, H., Kenerson, J. G., Alfonso, B., Olsen, M. H., Soares, M., Beaney, T, Schutte, A, Tomaszewski, M, Ariti, C, Burrell, L, Castillo, R, Charchar, F, Damasceno, A, Kruger, R, Lackland, D, Nilsson, P, Prabhakaran, D, Ramirez, A, Schlaich, M, Wang, J, Weber, M, Poulter, N, Napiza-Granada, C, Sevilla, M, Atilano, A, Ona, D, More, A, Jose, A, Maheshwari, A, Kondal, D, Yu, W, Li, W, Xu, S, Yu, J, Zhang, H, Widyantoro, B, Turana, Y, Situmorang, T, Sofiatin, Y, Barack, R, Lin, H, Wang, T, Chen, W, Sirenko, Y, Evstigneeva, O, Negresku, E, Yousif, M, Medani, S, Beheiry, H, Ali, I, Zilberman, J, Marin, M, Rodriguez, P, Garcia-Vasquez, F, Kramoh, K, Ekoua, D, Lopez-Jaramillo, P, Otero, J, Sanchez, G, Narvaez, C, Accini, J, Hernandez-Hernandez, R, Octavio, J, Morr, I, Lopez-Rivera, J, Ojji, D, Arije, A, Babatunte, A, Wahab, K, REIS FERNANDES, M, Pereira, S, Valentim, M, Dzudie, A, Kingue, S, Djomou Ngongang, D, Ogola, E, Barasa, F, Gitura, B, Malik, F, Choudhury, S, Al Mamun, M, Minh, V, Viet, N, Cao Truong, S, Ferri, C, Parati, G, Torlasco, C, Borghi, C, Goma, F, Syatalimi, C, Zelveian, P, Barbosa, E, Sebba Barroso, W, Penaherrera, E, Jarrin, E, Yusufali, A, Bazargani, N, Tsinamdzgvrishvili, B, Trapaidze, D, Neupane, D, Mishra, S, Jozwiak, J, Malyszko, J, Konradi, A, Chazova, I, Ishaq, M, Memon, F, Heagerty, A, Keitley, J, Brady, A, Cockcroft, J, Mcdonnell, B, Lanas, F, Chia, Y, Ndhlovu, H, Kiss, I, Ruilope, L, Ellenga Mbolla, B, Milhailidou, A, Woodiwiss, A, Perl, S, Dolan, E, Azevedo, V, Garre, L, Boggia, J, Lee, V, Kowlessur, S, Miglinas, M, Sukackiene, D, Wainford, R, Habonimana, D, Masupe, T, Ortellado, J, Wuerzner, G, Alcocer, L, Burazeri, G, Sanchez Delgado, E, Lovic, D, Mondo, C, Mostafa, A, Nadar, S, Valdez Tiburcio, O, Leiba, A, Dorobantu, M, De Backer, T, Chifamba, J, Stergiou, G, Nwokocha, C, Sokolovic, S, Toure, A, Connell, K, Khan, N, Burger, D, De Carvalho Rodrigues, M, Kramer, B, Schmieder, R, Unger, T, Wyss, F, Yameogo, N, Beistline, H, Kenerson, J, Alfonso, B, Olsen, M, Soares, M, Beaney, Thomas, Schutte, Aletta E, Tomaszewski, Maciej, Ariti, Cono, Burrell, Louise M, Castillo, Rafael R, Charchar, Fadi J, Damasceno, Albertino, Kruger, Ruan, Lackland, Daniel T, Nilsson, Peter M, Prabhakaran, Dorairaj, Ramirez, Agustin J, Schlaich, Markus P, Wang, Jiguang, Weber, Michael A, Poulter, Neil R, Napiza-Granada, C., Sevilla, Ma. RC, Atilano, A. A., Ona, D. I. D., More, A., Jose, A. P., Maheshwari, A., Kondal, D., Yu, W., Li, W., Xu, S., Yu, J., Zhang, H., Widyantoro, B., Turana, Y., Situmorang, T. D., Sofiatin, Y., Barack, R., Lin, H. -J., Wang, T. -D., Chen, W. -J., Sirenko, Y., Evstigneeva, O., Negresku, E., Yousif, M. E., Medani, S. A., Beheiry, H. M., Ali, I. A., Zilberman, J. M., Marin, M. J., Rodriguez, P. D., Garcia-Vasquez, F., Kramoh, K. E., Ekoua, D., Lopez-Jaramillo, P., Otero, J., Sanchez, G., Narvaez, C., Accini, J. L., Hernandez-Hernandez, R., Octavio, J. A., Morr, I., Lopez-Rivera, J., Ojji, D., Arije, A., Babatunte, A., Wahab, K. W., REIS FERNANDES, MARCOS ANTONIO, Pereira, S. V., Valentim, M., Dzudie, A., Kingue, S., Djomou Ngongang, D. A., Ogola, E. N., Barasa, F. A., Gitura, B., Malik, F-T-N, Choudhury, S. R., Al Mamun, M. A., Minh, V. H., Viet, N. L., Cao Truong, S., Ferri, C., Parati, G., Torlasco, C., Borghi, C., Goma, F. M., Syatalimi, C., Zelveian, P. H., Barbosa, E., Sebba Barroso, W., Penaherrera, E., Jarrin, E., Yusufali, A., Bazargani, N., Tsinamdzgvrishvili, B., Trapaidze, D., Neupane, D., Mishra, S. R., Jozwiak, J., Malyszko, J., Konradi, A., Chazova, I., Ishaq, M., Memon, F., Heagerty, A. M., Keitley, J., Brady, A. J. B., Cockcroft, J. R., McDonnell, B. J., Lanas, F., Chia, Y. -C., Ndhlovu, H., Kiss, I., Ruilope, L. M., Ellenga Mbolla, B. F., Milhailidou, A. S., Woodiwiss, A. J., Perl, S., Dolan, E., Azevedo, V., Garre, L., Boggia, J. G., Lee, V. W. Y., Kowlessur, S., Miglinas, M., Sukackiene, D., Wainford, R. D., Habonimana, D., Masupe, T., Ortellado, J., Wuerzner, G., Alcocer, L., Burazeri, G., Sanchez Delgado, E., Lovic, D., Mondo, C. K., Mostafa, A., Nadar, S. K., Valdez Tiburcio, O., Leiba, A., Dorobantu, M., De Backer, T., Chifamba, J., Stergiou, G., Nwokocha, C. R., Sokolovic, S., Toure, A. I., Connell, K. L., Khan, N. A., Burger, D., De Carvalho Rodrigues, M., Kramer, B. K., Schmieder, R. E., Unger, T., Wyss, F. S., Yameogo, N. V., Beistline, H., Kenerson, J. G., Alfonso, B., Olsen, M. H., and Soares, M.
Abstract: Background: Increased blood pressure is the biggest contributor to the global burden of disease and mortality. Data suggest that less than half of the population with hypertension is aware of it. May Measurement Month was initiated to raise awareness of the importance of blood pressure and as a pragmatic interim solution to the shortfall in screening programmes. Methods: This cross-sectional survey included volunteer adults (≥18 years) who ideally had not had their blood pressures measured in the past year. Each participant had their blood pressure measured three times and received a a questionnaire about demographic, lifestyle, and environmental factors. The primary objective was to raise awareness of blood pressure, measured by number of countries involved, number of people screened, and number of people who have untreated or inadequately treated hypertension (defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg, or both, or on the basis of receiving antihypertensive medication). Multiple imputation was used to estimate the mean of the second and third blood pressure readings if these were not recorded. Measures of association were analysed using linear mixed models. Findings: Data were collected from 1 201 570 individuals in 80 countries. After imputation, of the 1 128 635 individuals for whom a mean of the second and third readings was available, 393 924 (34·9%) individuals had hypertension. 153 905 (17·3%) of 888 616 individuals who were not receiving antihypertensive treatment were hypertensive, and 105 456 (46·3%) of the 227 721 individuals receiving treatment did not have controlled blood pressure. Significant differences in adjusted blood pressures and hypertension prevalence were apparent between regions. Adjusted blood pressure was higher in association with antihypertensive medication, diabetes, cerebrovascular disease, smoking, and alcohol consumption. Blood pressure was higher when measured on the right arm than on the le
Published: 2018

40. 2018 ESC/ESH guidelines for the diagnosis and treatment of arterial hypertension: The Task Force for the Diagnosis and Treatment of Arterial Hypertension of the European Society of Cardiology (ESC) and of the European Society of Hypertension (ESH)

Author: Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, De Backer, G, Heagerty, A, Agewall, S, Bochud, M, Borghi, C, Boutouyrie, P, Brguljan, J, Bueno, H, Caiani, E, Carlberg, B, Chapman, N, Cifkova, R, Cleland, J, Collet, J, Coman, I, De Leeuw, P, Delgado, V, Dendale, P, Diener, H, Dorobantu, M, Fagard, R, Farsang, C, Ferrini, M, Graham, I, Grassi, G, Haller, H, Richard Hobbs, F, Jelakovic, B, Jennings, C, Katus, H, Kroon, A, Leclercq, C, Lovic, D, Lurbe, E, Manolis, A, Mcdonagh, T, Messerli, F, Muiesan, M, Nixdorff, U, Olsen, M, Parati, G, Perk, J, Piepoli, M, Polonia, J, Ponikowski, P, Richter, D, Rimoldi, S, Roffi, M, Sattar, N, Seferovic, P, Simpson, I, Sousa-Uva, M, Stanton, A, Van De Borne, P, Vardas, P, Volpe, M, Wassmann, S, Windecker, S, Zamorano, J, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., De Backer G., Heagerty A. M., Agewall S., Bochud M., Borghi C., Boutouyrie P., Brguljan J., Bueno H., Caiani E. G., Carlberg B., Chapman N., Cifkova R., Cleland J. G. F., Collet J. -P., Coman I. M., De Leeuw P. W., Delgado V., Dendale P., Diener H. -C., Dorobantu M., Fagard R., Farsang C., Ferrini M., Graham I. M., Grassi G., Haller H., Richard Hobbs F. D., Jelakovic B., Jennings C., Katus H. A., Kroon A. A., Leclercq C., Lovic D., Lurbe E., Manolis A. J., McDonagh T. A., Messerli F., Muiesan M. L., Nixdorff U., Olsen M. H., Parati G., Perk J., Piepoli M. F., Polonia J., Ponikowski P., Richter D. J., Rimoldi S. F., Roffi M., Sattar N., Seferovic P. M., Simpson I. A., Sousa-Uva M., Stanton A. V., Van De Borne P., Vardas P., Volpe M., Wassmann S., Windecker S., Zamorano J. L., Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, De Backer, G, Heagerty, A, Agewall, S, Bochud, M, Borghi, C, Boutouyrie, P, Brguljan, J, Bueno, H, Caiani, E, Carlberg, B, Chapman, N, Cifkova, R, Cleland, J, Collet, J, Coman, I, De Leeuw, P, Delgado, V, Dendale, P, Diener, H, Dorobantu, M, Fagard, R, Farsang, C, Ferrini, M, Graham, I, Grassi, G, Haller, H, Richard Hobbs, F, Jelakovic, B, Jennings, C, Katus, H, Kroon, A, Leclercq, C, Lovic, D, Lurbe, E, Manolis, A, Mcdonagh, T, Messerli, F, Muiesan, M, Nixdorff, U, Olsen, M, Parati, G, Perk, J, Piepoli, M, Polonia, J, Ponikowski, P, Richter, D, Rimoldi, S, Roffi, M, Sattar, N, Seferovic, P, Simpson, I, Sousa-Uva, M, Stanton, A, Van De Borne, P, Vardas, P, Volpe, M, Wassmann, S, Windecker, S, Zamorano, J, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., De Backer G., Heagerty A. M., Agewall S., Bochud M., Borghi C., Boutouyrie P., Brguljan J., Bueno H., Caiani E. G., Carlberg B., Chapman N., Cifkova R., Cleland J. G. F., Collet J. -P., Coman I. M., De Leeuw P. W., Delgado V., Dendale P., Diener H. -C., Dorobantu M., Fagard R., Farsang C., Ferrini M., Graham I. M., Grassi G., Haller H., Richard Hobbs F. D., Jelakovic B., Jennings C., Katus H. A., Kroon A. A., Leclercq C., Lovic D., Lurbe E., Manolis A. J., McDonagh T. A., Messerli F., Muiesan M. L., Nixdorff U., Olsen M. H., Parati G., Perk J., Piepoli M. F., Polonia J., Ponikowski P., Richter D. J., Rimoldi S. F., Roffi M., Sattar N., Seferovic P. M., Simpson I. A., Sousa-Uva M., Stanton A. V., Van De Borne P., Vardas P., Volpe M., Wassmann S., Windecker S., and Zamorano J. L.
Published: 2018

41. 2018 ESC/ESHGuidelines for themanagement of arterial hypertension

Author: Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., Mcmanus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., Desormais I., Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D. L., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S. E., Kreutz R., Laurent S., Lip G. Y. H., Mcmanus R., Narkiewicz K., Ruschitzka F., Schmieder R. E., Shlyakhto E., Tsioufis C., Aboyans V., and Desormais I.
Abstract: Document reviewers: Guy De Backer (ESC Review Coordinator) (Belgium), Anthony M. Heagerty (ESH Review Co-ordinator) (UK), Stefan Agewall (Norway), Murielle Bochud (Switzerland), Claudio Borghi (Italy), Pierre Boutouyrie (France), Jana Brguljan (Slovenia), Hé ctor Bueno (Spain), Enrico G. Caiani (Italy), Bo Carlberg (Sweden), Neil Chapman (UK), Renata Cifkova (Czech Republic), John G. F. Cleland (UK), Jean-Philippe Collet (France), Ioan Mircea Coman (Romania), Peter W. de Leeuw (The Netherlands), Victoria Delgado (The Netherlands), Paul Dendale (Belgium), Hans-Christoph Diener (Germany), Maria Dorobantu (Romania), Robert Fagard (Belgium), Csaba Farsang (Hungary), Marc Ferrini (France), Ian M. Graham (Ireland), Guido Grassi (Italy), Hermann Haller (Germany), F. D. Richard Hobbs (UK), Bojan Jelakovic (Croatia), Catriona Jennings (UK), Hugo A. Katus (Germany), Abraham A. Kroon (The Netherlands), Christophe Leclercq (France), Dragan Lovic (Serbia), Empar Lurbe (Spain), Athanasios J. Manolis (Greece), Theresa A. McDonagh (UK), Franz Messerli (Switzerland), Maria Lorenza Muiesan (Italy), Uwe Nixdorff (Germany), Michael Hecht Olsen (Denmark), Gianfranco Parati (Italy), Joep Perk (Sweden), Massimo Francesco Piepoli (Italy), Jorge Polonia (Portugal), Piotr Ponikowski (Poland), Dimitrios J. Richter (Greece), Stefano F. Rimoldi (Switzerland), Marco Roffi (Switzerland), Naveed Sattar (UK), Petar M. Seferovic (Serbia), Iain A. Simpson (UK), Miguel Sousa-Uva (Portugal), Alice V. Stanton (Ireland), Philippe van de Borne (Belgium), Panos Vardas (Greece), Massimo Volpe (Italy), Sven Wassmann (Germany), Stephan Windecker (Switzerland), Jose Luis Zamorano (Spain). The disclosure forms of all experts involved in the development of these Guidelines are available on the ESC website www.escardio.org/guidelines.
Published: 2018

42. 2018 practice guidelines for the management of arterial hypertension of the European society of cardiology and the European society of hypertension ESC/ESH task force for the management of arterial hypertension

Author: Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, K, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R., Shlyakhto E., Tsioufis K., Aboyans V., Desormais I., Williams, B, Mancia, G, Spiering, W, Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, K, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Rosei E. A., Azizi M., Burnier M., Clement D., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R., Shlyakhto E., Tsioufis K., Aboyans V., and Desormais I.
Abstract: Blood pressure, epidemiology and risk. Globally, over 1 billion people have hypertension. As populations age and adopt more sedentary lifestyles, the worldwide prevalence of hypertension will continue to rise towards 1.5 billion by 2025. Elevated blood pressure (BP) is the leading global contributor to premature death, accounting for almost 10 million deaths in 2015, 4.9 million due to ischaemic heart disease and 3.5 million due to stroke. Hypertension is also a major risk factor for heart failure, atrial fibrillation, chronic kidney disease (CKD), peripheral artery disease (PAD) and cognitive decline. 2. Definition of hypertension. The classification of BP and the definition of hypertension is unchanged from previous European guidelines, and is defined as an office SBP at least 140 mmHg and/or DBP at least 90 mmHg, which is equivalent to a 24-h ABPM average of at least 130/80 mmHg, or a home blood pressure monitoring (HBPM) average at least 135/ 85 mmHg. 3. Screening and diagnosis of hypertension. Hypertension is usually asymptomatic (hence the term 'silent killer'). Because of its high prevalence, screening programmes should be established to ensure that BP is measured in all adults, at least every 5 years and more frequently in people with a high-normal BP. When hypertension is suspected because of an elevated screening BP, the diagnosis of hypertension should be confirmed either by repeated office BP measurements, over a number of visits, or by out-of-office BP measurement using 24-h ABPM or by HBPM. 4. The importance of cardiovascular risk assessment and detection of HMOD. Other cardiovascular risk factors such as dyslipidaemia and metabolic syndrome frequently cluster with hypertension. Thus, unless the patient is already at high or very high risk due to established CVD, formal cardiovascular risk assessment is recommended using the SCORE system. It is important to recognize, however, that the presence of HMOD, especially left ventricular hypertrophy (LVH), ch
Published: 2018

43. 2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC)

Author: Williams, B, Mancia, G, Spiering, W, Agabiti Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, K, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Agabiti Rosei E., Azizi M., Burnier M., Clement D., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R., Shlyakhto E., Tsioufis K., Aboyans V., Desormais I., Williams, B, Mancia, G, Spiering, W, Agabiti Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, De Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, K, Aboyans, V, Desormais, I, Williams B., Mancia G., Spiering W., Agabiti Rosei E., Azizi M., Burnier M., Clement D., Coca A., De Simone G., Dominiczak A., Kahan T., Mahfoud F., Redon J., Ruilope L., Zanchetti A., Kerins M., Kjeldsen S., Kreutz R., Laurent S., Lip G. Y. H., McManus R., Narkiewicz K., Ruschitzka F., Schmieder R., Shlyakhto E., Tsioufis K., Aboyans V., and Desormais I.
Abstract: These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and the European Society of Cardiology. These guidelines have been prepared on the basis of the best available evidence on all issues deserving recommendations; their role must be educational and not prescriptive or coercive for the management of individual subjects who may differ widely in their personal, medical and cultural characteristics. The members of the Task Force have participated independently in the preparation of these guidelines, drawing on their academic and clinical experience and by objective examination and interpretation of all available literature.
Published: 2018

44. Cardiovascular risk profile and risk stratification of the hypertensive population attended by general practitioners and specialists in Spain. The CONTROLRISK study

Author: Barrios, V, Escobar, C, Calderón, A, Echarri, R, González-Pedel, V, and Ruilope, L M
Published: 2007
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45. Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies

Author: Mahfoud, F. Azizi, M. Ewen, S. Pathak, A. Ukena, C. Blankestijn, P.J. Böhm, M. Burnier, M. Chatellier, G. Durand Zaleski, I. Grassi, G. Joner, M. Kandzari, D.E. Kirtane, A. Kjeldsen, S.E. Lobo, M.D. Lüscher, T.F. McEvoy, J.W. Parati, G. Rossignol, P. Ruilope, L. Schlaich, M.P. Shahzad, A. Sharif, F. Sharp, A.S.P. Sievert, H. Volpe, M. Weber, M.A. Schmieder, R.E. Tsioufis, C. Wijns, W.
Published: 2020

46. Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

Author: Bakris G, Agarwal R, Anker S, Pitt B, Ruilope L, Rossing P, Kolkhof P, Nowack C, Schloemer P, Joseph A, Filippatos G, and FIDELIO-DKD Investigators
Abstract: BACKGROUND: Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials involving patients with chronic kidney disease (CKD) and type 2 diabetes. However, its long-term effects on kidney and cardiovascular outcomes are unknown. METHODS: In this double-blind trial, we randomly assigned 5734 patients with CKD and type 2 diabetes in a 1:1 ratio to receive finerenone or placebo. Eligible patients had a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of 30 to less than 300, an estimated glomerular filtration rate (eGFR) of 25 to less than 60 ml per minute per 1.73 m2 of body-surface area, and diabetic retinopathy, or they had a urinary albumin-to-creatinine ratio of 300 to 5000 and an eGFR of 25 to less than 75 ml per minute per 1.73 m2. All the patients were treated with renin-angiotensin system blockade that had been adjusted before randomization to the maximum dose on the manufacturer's label that did not cause unacceptable side effects. The primary composite outcome, assessed in a time-to-event analysis, was kidney failure, a sustained decrease of at least 40% in the eGFR from baseline, or death from renal causes. The key secondary composite outcome, also assessed in a time-to-event analysis, was death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. RESULTS: During a median follow-up of 2.6 years, a primary outcome event occurred in 504 of 2833 patients (17.8%) in the finerenone group and 600 of 2841 patients (21.1%) in the placebo group (hazard ratio, 0.82; 95% confidence interval [CI], 0.73 to 0.93; P=0.001). A key secondary outcome event occurred in 367 patients (13.0%) and 420 patients (14.8%) in the respective groups (hazard ratio, 0.86; 95% CI, 0.75 to 0.99; P=0.03). Overall, the frequency of adverse events was similar in the two groups. The incidence of hyperkalemia-related discontinuation of the trial regimen was higher with finerenone than with placebo (2.3% and 0.9%, respectively). CONCLUSIONS: In patients with CKD and type 2 diabetes, treatment with finerenone resulted in lower risks of CKD progression and cardiovascular events than placebo. (Funded by Bayer; FIDELIO-DKD ClinicalTrials.gov number, NCT02540993.).
Published: 2020

47. Rationale and design of a study to evaluate management of proteinuria in patients at high risk for vascular events: the IMPROVE trial

Author: Bakris, G L, Ruilope, L, Locatelli, F, Ptaszynska, A, Pieske, B, Raz, I, Voors, A A, Dechamplain, J, and Weber, M A
Published: 2006
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48. Patients With Resistant Hypertension in the Global SYMPLICITY Registry: Antihypertensive Medication Burden and Changes in Blood Pressure out to 3 Years

Author: Schlaich, M, Böhm, M, Mancia, G, Schmieder, R, Narkiewicz, K, Ruilope, L, Williams, B, Shen, C, Mahfoud, F, Schlaich, M, Böhm, M, Mancia, G, Schmieder, R, Narkiewicz, K, Ruilope, L, Williams, B, Shen, C, and Mahfoud, F
Published: 2020

49. May measurement month 2019: The global blood pressure screening campaign of the international society of hypertension

Author: Thomas, B, Aletta E, S, George S, S, Claudio, B, Dylan, B, Fadi, C, Suzie, C, Alejandro, D, Albertino, D, Walter, E, Arun Pulikkottil, J, Nadia, K, Yoshihiro, K, Anuj, M, Marcos J, M, Arun, M, Dinesh, N, Peter, N, Mansi, P, Dorairaj, P, Agustin, R, Pablo, R, Markus, S, Ulrike M, S, Maciej, T, Thomas, U, Richard, W, Jiguang, W, Bryan, W, Neil R, P, H Olsen, M, T West-Gustave, K, D Levy, P, Lee, V, L Connell, K, Hammoudi, N, Bovet, P, Viswanathan, B, Perl, S, K Kramer, B, Brady, A, O Oladapo, O, Chifamba, J, Y Goshu, D, M Kassie, D, A Gebru, S, A Ibrahim, T, Kabirou, S, Tavassoli, E, Zolfaghari, M, Yavari, V, Mishchenko, L, Matova, O, Kolenyk, T, Zelenenka, L, Fedorov, S, Dorobantu, M, Paval, A, Bittman, J, Mangat, B, Melville, S, Leung, A, Jessen, N, Dolan, E, Itoh, H, Pathak, A, De Backer, T, S Postadzhiyan, A, V Valoy-Tiburcio, O, R Gonzalez-Medina, A, G Valdez-Valoy, L, S Wyss, F, Mirrakhimov, E, K Nadar, S, I Barrientos, A, R Nwokocha, C, I Nwokocha, M, Picone, D, Yang, J, C Chia, Y, M Ching, S, F Ellenga Mbolla, B, M Kouala Landa, C, Y Houehanou, C, W Wahab, K, B Omotoso, A, Ortellado, J, Gonzales, G, M Ruilope, L, Rodilla, E, Molinero, A, J Woodiwiss, A, Orchard, A, Kruger, R, Brguljan, J, Bozic, N, O Konradi, A, P Rotar, O, Chazova, I, K Masupe, T, T Tlhakanelo, J, Motlhatlhedi, K, Stergiou, G, Doumas, M, Zebekakis, P, P Cappuccio, F, Barciela, C, Tay, T, Dashdorj, N, Tuvdendarjaa, K, Boldbaatar, K, T Lanas, F, Paccot, M, Ishaq, M, Sidique, S, Memon, F, N Najem, R, K Abu Alfa, A, Mallat, S, J Jozwiak, J, Banach, M, Janowski, P, Twumasi-Ankrah, B, A Myers-Hansen, G, K Tannor, E, F Neto, M, Kowlessur, S, Ori, B, Heecharan, J, A Fageh, H, A Derbi, H, M Msalam, O, M Goma, F, Syatalimi, C, Jr Tembo, P, Mukupa, M, L Ndhlovu, H, L Chirwa, M, M Mbeba, M, H Zelveian, P, N Hakobyan, Z, Gourgenyan, S, Cho, M, Lee, H, Shin, J, Parati, G, Grassi, G, Ferri, C, Tsinamdzgvrishvili, B, Gamkrelidze, A, Trapaidze, D, Barbosa, E, S Barroso, W, M Feitosa, A, M Azevedo, V, A Dias, L, N Garcia, G, Delgado, I, Burazeri, G, Qirjako, G, Ylli, A, Cumashi, R, P Costantini-Olmos, A, Morr, I, Chuki, E, Wang, T, Chen, W, Lin, H, Malik, F, R Choudhury, S, Abdullah Al Mamun, M, Ishraquzzaman, M, S Aljuraiban, G, Y Al Slail, F, K Aldhwailea, S, A Badawi, A, L Viet, N, A Tien, H, Dong, N, T Sinh, C, V Minh, H, K Son, T, K Katamba, F, B Buila, N, Dzudie, A, Kingue, S, Epie, N, Njomou, A, S Ndom, M, M Yusufali, A, M Bazargani, N, Bin Belaila, B, Agrawal, A, M Suhail, A, N Ogola, E, M Gitura, B, Mbau, L, K Nguchu, H, A Barasa, F, Gomez, E, A Alcocer, L, Rosas, M, Palomo, S, J Estrada, A, Lopez-Jaramillo, P, Sanchez-Vallejo, G, E Casanova, M, Arcos, E, Aroca, G, Koirala, B, Bhattarai, H, Pandey, G, Devkota, S, Koirala, S, Ranabhat, K, Khanal, P, B Adhikari, T, D Bonzon, D, D Ona, D, M Asis, L, A Balmores Jr, B, C Castillo, R, J Stisman, D, G Espeche, W, J Marin, M, L Ennis, I, Chen, X, Wang, H, Liu, M, Yin, X, Wang, X, Bhalla, S, Gupta, P, Verma, N, K Gupta, B, Sheikh, S, Wuerzner, G, Garré, L, Boggia, J, M Houenassi, D, A OctavioSeijas, J, M'buyamba-Kabangu, J, M Tshiswaka, T, Páll, D, Járai, Z, Hernández, R, Garcia Vásquez, F, A Lopez-Rivera, J, L Gúzman-Franolic, M, Victoria Pereira, S, J Fernandes, M, S Garcia, M, Gijon, T, Meira Da Cunha, V, Beaney, Thomas, Schutte, Aletta E, Stergiou, George S, Borghi, Claudio, Burger, Dylan, Charchar, Fadi, Cro, Suzie, Diaz, Alejandro, Damasceno, Albertino, Espeche, Walter, Jose, Arun Pulikkottil, Khan, Nadia, Kokubo, Yoshihiro, Maheshwari, Anuj, Marin, Marcos J, More, Arun, Neupane, Dinesh, Nilsson, Peter, Patil, Mansi, Prabhakaran, Dorairaj, Ramirez, Agustin, Rodriguez, Pablo, Schlaich, Markus, Steckelings, Ulrike M, Tomaszewski, Maciej, Unger, Thomas, Wainford, Richard, Wang, Jiguang, Williams, Bryan, Poulter, Neil R, Michael H Olsen, Kristin T West-Gustave, Phillip D Levy, Vivian W. Y. Lee, Kenneth L Connell, Naima N. H. Hammoudi, Pascal Bovet, Bharathi Viswanathan, Sabine Perl, Bernard K Kramer, Adrian J. B. Brady, Olulola O Oladapo, Jephat Chifamba, Dejuma Y Goshu, Desalew M Kassie, Sintayehu A Gebru, Toure A Ibrahim, Soumana Kabirou, Elham Tavassoli, Mahsa Zolfaghari, Vahideh Yavari, Larysa Mishchenko, Olena Matova, Tetiana Kolenyk, Liliiya Zelenenka, Sergiy Fedorov, Maria Dorobantu, Alexandra Paval, Jesse Bittman, Biri Mangat, Sarah Melville, Alexander Leung, Neusa Jessen, Eamon Dolan, Hiroshi N. A. Itoh, Atul Pathak, Tine L. M. De Backer, Arman S Postadzhiyan, Osiris V Valoy-Tiburcio, Angel R Gonzalez-Medina, Laura G Valdez-Valoy, Fernando S Wyss, Erkin Mirrakhimov, Sunil K Nadar, Ana I Barrientos, Chukwuemeka R Nwokocha, Magdalene I Nwokocha, Dean Picone, Jun Yang, Yook C Chia, Siew M Ching, Bertrand F Ellenga Mbolla, Christian M Kouala Landa, Corine Y Houehanou, Kolawole W Wahab, Ayodele B Omotoso, Jose Ortellado, Graciela Gonzales, Luis M Ruilope, Enrique Rodilla, Ana Molinero, Angela J Woodiwiss, Ane Orchard, Ruan Kruger, Jana Brguljan, Nina Bozic, Aleksandra O Konradi, Oxana P Rotar, Irian Chazova, Tiny K Masupe, John T Tlhakanelo, Keneilwe Motlhatlhedi, George Stergiou, Michalis Doumas, Pantelis Zebekakis, Francesco P Cappuccio, Carolina Barciela, Tricia Tay, Naranjargal Dashdorj, Khulan Tuvdendarjaa, Khatantuul Boldbaatar, Fernando T Lanas, Melanie Paccot, Mohammed Ishaq, Saulat Sidique, Feroz Memon, Robert N Najem, Ali K Abu Alfa, Samir M. J. Mallat, Jacek J Jozwiak, Maciej Banach, Piotr Janowski, Betty Twumasi-Ankrah, Gustavus A Myers-Hansen, Elliot K Tannor, Marisa F Neto, Sudhirsen Kowlessur, Bhooshun Ori, Jaysing Heecharan, Hatem A Fageh, Hawa A Derbi, Omara M Msalam, Fastone M Goma, Charity Syatalimi, Penias Jr Tembo, Musawa Mukupa, Henry L Ndhlovu, Maureen L Chirwa, Mary M Mbeba, Parounak H Zelveian, Zoya N Hakobyan, Svetlana Gourgenyan, Myeong-Chan Cho, Hae-Young Lee, Jinho Shin, Gianfranco Parati, Guido Grassi, Claudio Ferri, Bezhan Tsinamdzgvrishvili, Amiran Gamkrelidze, Dali Trapaidze, Eduardo C. D. Barbosa, Weimar S Barroso, Audes M Feitosa, Vanda M Azevedo, Luis A Dias, Glenda N Garcia, Isaulina Delgado, Genc Burazeri, Gentiana Qirjako, Alban Ylli, Rudina Cumashi, Antonieta P Costantini-Olmos, Igor Morr, Elias Chuki, Tzung-Dau Wang, Wen-Jone Chen, Hung-Ju Lin, Fazila-Tun-Nesa Malik, Sohel R Choudhury, Mohammad Abdullah Al Mamun, Mir Ishraquzzaman, Ghadeer S Aljuraiban, Fatima Y Al Slail, Shatha K Aldhwailea, Ann A Badawi, Nguyen L Viet, Hoang A Tien, Nguyen T. A. Dong, Cao T Sinh, Huynh V Minh, Tran K Son, Fortunat K Katamba, Nathan B Buila, Anastase Dzudie, Samuel Kingue, Njume Epie, Armel Njomou, Marie S Ndom, Afzalhussein M Yusufali, Nooshin M Bazargani, Buthaina A. Bin Belaila, Amrish Agrawal, Aisha M Suhail, Elijah N Ogola, Bernard M Gitura, Lilian Mbau, Hellen K Nguchu, Felix A Barasa, Enrique Gomez, Luis A Alcocer, Martin Rosas, Silvia Palomo, Alfredo J Estrada, Patricio Lopez-Jaramillo, Gregorio Sanchez-Vallejo, Maria E Casanova, Edgar Arcos, Gustavo Aroca, Bhagawan Koirala, Harikrishna Bhattarai, Ghanashyam Pandey, Surya Devkota, Sweta Koirala, Kamal Ranabhat, Pratik Khanal, Tara B Adhikari, Dolores D Bonzon, Deborah Ignacia D Ona, Leilani M Asis, Benjamin A Balmores Jr, Rafael C Castillo, Diego J Stisman, Walter G Espeche, Marcos J Marin, Irene L Ennis, Xin Chen, Hongyu Wang, Min Liu, Xinhua Yin, Xiaolong Wang, Sandeep Bhalla, Priyanka Gupta, Narsingh Verma, Bal K Gupta, Shehla Sheikh, Gregoire Wuerzner, Laura Garré, José Boggia, Dédonougbo M Houenassi, José A OctavioSeijas, Jean-René M'buyamba-Kabangu, Trésor M Tshiswaka, Dénes Páll, Zoltán Járai, Rafael Hernández, Fortunato Garcia Vásquez, Jesús A Lopez-Rivera, Monica L Gúzman-Franolic, Savarino Victoria Pereira, Mário J Fernandes, Maria S Garcia, Teresa Gijon, Vitoria V. B. Meira Da Cunha, Thomas, B, Aletta E, S, George S, S, Claudio, B, Dylan, B, Fadi, C, Suzie, C, Alejandro, D, Albertino, D, Walter, E, Arun Pulikkottil, J, Nadia, K, Yoshihiro, K, Anuj, M, Marcos J, M, Arun, M, Dinesh, N, Peter, N, Mansi, P, Dorairaj, P, Agustin, R, Pablo, R, Markus, S, Ulrike M, S, Maciej, T, Thomas, U, Richard, W, Jiguang, W, Bryan, W, Neil R, P, H Olsen, M, T West-Gustave, K, D Levy, P, Lee, V, L Connell, K, Hammoudi, N, Bovet, P, Viswanathan, B, Perl, S, K Kramer, B, Brady, A, O Oladapo, O, Chifamba, J, Y Goshu, D, M Kassie, D, A Gebru, S, A Ibrahim, T, Kabirou, S, Tavassoli, E, Zolfaghari, M, Yavari, V, Mishchenko, L, Matova, O, Kolenyk, T, Zelenenka, L, Fedorov, S, Dorobantu, M, Paval, A, Bittman, J, Mangat, B, Melville, S, Leung, A, Jessen, N, Dolan, E, Itoh, H, Pathak, A, De Backer, T, S Postadzhiyan, A, V Valoy-Tiburcio, O, R Gonzalez-Medina, A, G Valdez-Valoy, L, S Wyss, F, Mirrakhimov, E, K Nadar, S, I Barrientos, A, R Nwokocha, C, I Nwokocha, M, Picone, D, Yang, J, C Chia, Y, M Ching, S, F Ellenga Mbolla, B, M Kouala Landa, C, Y Houehanou, C, W Wahab, K, B Omotoso, A, Ortellado, J, Gonzales, G, M Ruilope, L, Rodilla, E, Molinero, A, J Woodiwiss, A, Orchard, A, Kruger, R, Brguljan, J, Bozic, N, O Konradi, A, P Rotar, O, Chazova, I, K Masupe, T, T Tlhakanelo, J, Motlhatlhedi, K, Stergiou, G, Doumas, M, Zebekakis, P, P Cappuccio, F, Barciela, C, Tay, T, Dashdorj, N, Tuvdendarjaa, K, Boldbaatar, K, T Lanas, F, Paccot, M, Ishaq, M, Sidique, S, Memon, F, N Najem, R, K Abu Alfa, A, Mallat, S, J Jozwiak, J, Banach, M, Janowski, P, Twumasi-Ankrah, B, A Myers-Hansen, G, K Tannor, E, F Neto, M, Kowlessur, S, Ori, B, Heecharan, J, A Fageh, H, A Derbi, H, M Msalam, O, M Goma, F, Syatalimi, C, Jr Tembo, P, Mukupa, M, L Ndhlovu, H, L Chirwa, M, M Mbeba, M, H Zelveian, P, N Hakobyan, Z, Gourgenyan, S, Cho, M, Lee, H, Shin, J, Parati, G, Grassi, G, Ferri, C, Tsinamdzgvrishvili, B, Gamkrelidze, A, Trapaidze, D, Barbosa, E, S Barroso, W, M Feitosa, A, M Azevedo, V, A Dias, L, N Garcia, G, Delgado, I, Burazeri, G, Qirjako, G, Ylli, A, Cumashi, R, P Costantini-Olmos, A, Morr, I, Chuki, E, Wang, T, Chen, W, Lin, H, Malik, F, R Choudhury, S, Abdullah Al Mamun, M, Ishraquzzaman, M, S Aljuraiban, G, Y Al Slail, F, K Aldhwailea, S, A Badawi, A, L Viet, N, A Tien, H, Dong, N, T Sinh, C, V Minh, H, K Son, T, K Katamba, F, B Buila, N, Dzudie, A, Kingue, S, Epie, N, Njomou, A, S Ndom, M, M Yusufali, A, M Bazargani, N, Bin Belaila, B, Agrawal, A, M Suhail, A, N Ogola, E, M Gitura, B, Mbau, L, K Nguchu, H, A Barasa, F, Gomez, E, A Alcocer, L, Rosas, M, Palomo, S, J Estrada, A, Lopez-Jaramillo, P, Sanchez-Vallejo, G, E Casanova, M, Arcos, E, Aroca, G, Koirala, B, Bhattarai, H, Pandey, G, Devkota, S, Koirala, S, Ranabhat, K, Khanal, P, B Adhikari, T, D Bonzon, D, D Ona, D, M Asis, L, A Balmores Jr, B, C Castillo, R, J Stisman, D, G Espeche, W, J Marin, M, L Ennis, I, Chen, X, Wang, H, Liu, M, Yin, X, Wang, X, Bhalla, S, Gupta, P, Verma, N, K Gupta, B, Sheikh, S, Wuerzner, G, Garré, L, Boggia, J, M Houenassi, D, A OctavioSeijas, J, M'buyamba-Kabangu, J, M Tshiswaka, T, Páll, D, Járai, Z, Hernández, R, Garcia Vásquez, F, A Lopez-Rivera, J, L Gúzman-Franolic, M, Victoria Pereira, S, J Fernandes, M, S Garcia, M, Gijon, T, Meira Da Cunha, V, Beaney, Thomas, Schutte, Aletta E, Stergiou, George S, Borghi, Claudio, Burger, Dylan, Charchar, Fadi, Cro, Suzie, Diaz, Alejandro, Damasceno, Albertino, Espeche, Walter, Jose, Arun Pulikkottil, Khan, Nadia, Kokubo, Yoshihiro, Maheshwari, Anuj, Marin, Marcos J, More, Arun, Neupane, Dinesh, Nilsson, Peter, Patil, Mansi, Prabhakaran, Dorairaj, Ramirez, Agustin, Rodriguez, Pablo, Schlaich, Markus, Steckelings, Ulrike M, Tomaszewski, Maciej, Unger, Thomas, Wainford, Richard, Wang, Jiguang, Williams, Bryan, Poulter, Neil R, Michael H Olsen, Kristin T West-Gustave, Phillip D Levy, Vivian W. Y. Lee, Kenneth L Connell, Naima N. H. Hammoudi, Pascal Bovet, Bharathi Viswanathan, Sabine Perl, Bernard K Kramer, Adrian J. B. Brady, Olulola O Oladapo, Jephat Chifamba, Dejuma Y Goshu, Desalew M Kassie, Sintayehu A Gebru, Toure A Ibrahim, Soumana Kabirou, Elham Tavassoli, Mahsa Zolfaghari, Vahideh Yavari, Larysa Mishchenko, Olena Matova, Tetiana Kolenyk, Liliiya Zelenenka, Sergiy Fedorov, Maria Dorobantu, Alexandra Paval, Jesse Bittman, Biri Mangat, Sarah Melville, Alexander Leung, Neusa Jessen, Eamon Dolan, Hiroshi N. A. Itoh, Atul Pathak, Tine L. M. De Backer, Arman S Postadzhiyan, Osiris V Valoy-Tiburcio, Angel R Gonzalez-Medina, Laura G Valdez-Valoy, Fernando S Wyss, Erkin Mirrakhimov, Sunil K Nadar, Ana I Barrientos, Chukwuemeka R Nwokocha, Magdalene I Nwokocha, Dean Picone, Jun Yang, Yook C Chia, Siew M Ching, Bertrand F Ellenga Mbolla, Christian M Kouala Landa, Corine Y Houehanou, Kolawole W Wahab, Ayodele B Omotoso, Jose Ortellado, Graciela Gonzales, Luis M Ruilope, Enrique Rodilla, Ana Molinero, Angela J Woodiwiss, Ane Orchard, Ruan Kruger, Jana Brguljan, Nina Bozic, Aleksandra O Konradi, Oxana P Rotar, Irian Chazova, Tiny K Masupe, John T Tlhakanelo, Keneilwe Motlhatlhedi, George Stergiou, Michalis Doumas, Pantelis Zebekakis, Francesco P Cappuccio, Carolina Barciela, Tricia Tay, Naranjargal Dashdorj, Khulan Tuvdendarjaa, Khatantuul Boldbaatar, Fernando T Lanas, Melanie Paccot, Mohammed Ishaq, Saulat Sidique, Feroz Memon, Robert N Najem, Ali K Abu Alfa, Samir M. J. Mallat, Jacek J Jozwiak, Maciej Banach, Piotr Janowski, Betty Twumasi-Ankrah, Gustavus A Myers-Hansen, Elliot K Tannor, Marisa F Neto, Sudhirsen Kowlessur, Bhooshun Ori, Jaysing Heecharan, Hatem A Fageh, Hawa A Derbi, Omara M Msalam, Fastone M Goma, Charity Syatalimi, Penias Jr Tembo, Musawa Mukupa, Henry L Ndhlovu, Maureen L Chirwa, Mary M Mbeba, Parounak H Zelveian, Zoya N Hakobyan, Svetlana Gourgenyan, Myeong-Chan Cho, Hae-Young Lee, Jinho Shin, Gianfranco Parati, Guido Grassi, Claudio Ferri, Bezhan Tsinamdzgvrishvili, Amiran Gamkrelidze, Dali Trapaidze, Eduardo C. D. Barbosa, Weimar S Barroso, Audes M Feitosa, Vanda M Azevedo, Luis A Dias, Glenda N Garcia, Isaulina Delgado, Genc Burazeri, Gentiana Qirjako, Alban Ylli, Rudina Cumashi, Antonieta P Costantini-Olmos, Igor Morr, Elias Chuki, Tzung-Dau Wang, Wen-Jone Chen, Hung-Ju Lin, Fazila-Tun-Nesa Malik, Sohel R Choudhury, Mohammad Abdullah Al Mamun, Mir Ishraquzzaman, Ghadeer S Aljuraiban, Fatima Y Al Slail, Shatha K Aldhwailea, Ann A Badawi, Nguyen L Viet, Hoang A Tien, Nguyen T. A. Dong, Cao T Sinh, Huynh V Minh, Tran K Son, Fortunat K Katamba, Nathan B Buila, Anastase Dzudie, Samuel Kingue, Njume Epie, Armel Njomou, Marie S Ndom, Afzalhussein M Yusufali, Nooshin M Bazargani, Buthaina A. Bin Belaila, Amrish Agrawal, Aisha M Suhail, Elijah N Ogola, Bernard M Gitura, Lilian Mbau, Hellen K Nguchu, Felix A Barasa, Enrique Gomez, Luis A Alcocer, Martin Rosas, Silvia Palomo, Alfredo J Estrada, Patricio Lopez-Jaramillo, Gregorio Sanchez-Vallejo, Maria E Casanova, Edgar Arcos, Gustavo Aroca, Bhagawan Koirala, Harikrishna Bhattarai, Ghanashyam Pandey, Surya Devkota, Sweta Koirala, Kamal Ranabhat, Pratik Khanal, Tara B Adhikari, Dolores D Bonzon, Deborah Ignacia D Ona, Leilani M Asis, Benjamin A Balmores Jr, Rafael C Castillo, Diego J Stisman, Walter G Espeche, Marcos J Marin, Irene L Ennis, Xin Chen, Hongyu Wang, Min Liu, Xinhua Yin, Xiaolong Wang, Sandeep Bhalla, Priyanka Gupta, Narsingh Verma, Bal K Gupta, Shehla Sheikh, Gregoire Wuerzner, Laura Garré, José Boggia, Dédonougbo M Houenassi, José A OctavioSeijas, Jean-René M'buyamba-Kabangu, Trésor M Tshiswaka, Dénes Páll, Zoltán Járai, Rafael Hernández, Fortunato Garcia Vásquez, Jesús A Lopez-Rivera, Monica L Gúzman-Franolic, Savarino Victoria Pereira, Mário J Fernandes, Maria S Garcia, Teresa Gijon, and Vitoria V. B. Meira Da Cunha
Abstract: Elevated blood pressure remains the single biggest risk factor contributing to the global burden of disease and mortality. May Measurement Month is an annual global screening campaign aiming to improve awareness of blood pressure at the individual and population level. Adults (≥18 years) recruited through opportunistic sampling were screened at sites in 92 countries during May 2019. Ideally, 3 blood pressure readings were measured for each participant, and data on lifestyle factors and comorbidities were collected. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, or a diastolic blood pressure ≥90 mm Hg (mean of the second and third readings) or taking antihypertensive medication. When necessary, multiple imputation was used to estimate participants' mean blood pressure. Mixed-effects models were used to evaluate associations between blood pressure and participant characteristics. Of 1 508 130 screenees 482 273 (32.0%) had never had a blood pressure measurement before and 513 337 (34.0%) had hypertension, of whom 58.7% were aware, and 54.7% were on antihypertensive medication. Of those on medication, 57.8% were controlled to <140/90 mm Hg, and 28.9% to <130/80 mm Hg. Of all those with hypertension, 31.7% were controlled to <140/90 mm Hg, and 350 825 (23.3%) participants had untreated or inadequately treated hypertension. Of those taking antihypertensive medication, half were taking only a single drug, and 25% reported using aspirin inappropriately. This survey is the largest ever synchronized and standardized contemporary compilation of global blood pressure data. This campaign is needed as a temporary substitute for systematic blood pressure screening in many countries worldwide.
Published: 2020

50. Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies

Author: Mahfoud, F, Azizi, M, Ewen, S, Pathak, A, Ukena, C, Blankestijn, P, Böhm, M, Burnier, M, Chatellier, G, Durand Zaleski, I, Grassi, G, Joner, M, Kandzari, D, Kirtane, A, Kjeldsen, S, Lobo, M, Lüscher, T, Mcevoy, J, Parati, G, Rossignol, P, Ruilope, L, Schlaich, M, Shahzad, A, Sharif, F, Sharp, A, Sievert, H, Volpe, M, Weber, M, Schmieder, R, Tsioufis, C, Wijns, W, Mahfoud, Felix, Azizi, Michel, Ewen, Sebastian, Pathak, Atul, Ukena, Christian, Blankestijn, Peter J, Böhm, Michael, Burnier, Michel, Chatellier, Gilles, Durand Zaleski, Isabelle, Grassi, Guido, Joner, Michael, Kandzari, David E, Kirtane, Ajay, Kjeldsen, Sverre E, Lobo, Melvin D, Lüscher, Thomas F, McEvoy, John William, Parati, Gianfranco, Rossignol, Patrick, Ruilope, Luis, Schlaich, Markus P, Shahzad, Atif, Sharif, Faisal, Sharp, Andrew S P, Sievert, Horst, Volpe, Massimo, Weber, Michael A, Schmieder, Roland E, Tsioufis, Costas, Wijns, William, Mahfoud, F, Azizi, M, Ewen, S, Pathak, A, Ukena, C, Blankestijn, P, Böhm, M, Burnier, M, Chatellier, G, Durand Zaleski, I, Grassi, G, Joner, M, Kandzari, D, Kirtane, A, Kjeldsen, S, Lobo, M, Lüscher, T, Mcevoy, J, Parati, G, Rossignol, P, Ruilope, L, Schlaich, M, Shahzad, A, Sharif, F, Sharp, A, Sievert, H, Volpe, M, Weber, M, Schmieder, R, Tsioufis, C, Wijns, W, Mahfoud, Felix, Azizi, Michel, Ewen, Sebastian, Pathak, Atul, Ukena, Christian, Blankestijn, Peter J, Böhm, Michael, Burnier, Michel, Chatellier, Gilles, Durand Zaleski, Isabelle, Grassi, Guido, Joner, Michael, Kandzari, David E, Kirtane, Ajay, Kjeldsen, Sverre E, Lobo, Melvin D, Lüscher, Thomas F, McEvoy, John William, Parati, Gianfranco, Rossignol, Patrick, Ruilope, Luis, Schlaich, Markus P, Shahzad, Atif, Sharif, Faisal, Sharp, Andrew S P, Sievert, Horst, Volpe, Massimo, Weber, Michael A, Schmieder, Roland E, Tsioufis, Costas, and Wijns, William
Published: 2020

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