109 results on '"Ruijs, M."'
Search Results
2. TP53 germline mutation testing in early-onset breast cancer: findings from a nationwide cohort
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Bakhuizen, J. J., Hogervorst, F. B., Velthuizen, M. E., Ruijs, M. W., van Engelen, K., van Os, T. A., Gille, J. J., Collée, M., van den Ouweland, A. M., van Asperen, C. J., Kets, C. M., Mensenkamp, A. R., Leter, E. M., Blok, M. J., de Jong, M. M., and Ausems, M. G.
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- 2019
- Full Text
- View/download PDF
3. AgTech Ecosystem Kentucky: inception study
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Ruijs, M., Hennen, W., Ravensbergen, P., Ruijs, M., Hennen, W., and Ravensbergen, P.
- Abstract
An inception study has been conducted of an intended feasibility study into the opportunities of AgTech ecosystem development, in particular greenhouse horticulture, in Kentucky. The current situation and possible follow-up steps have been mapped out by means of a spatial analysis of production locations for greenhouse horticulture, a market and value chain analysis, technical analysis of making production more sustainable and the governance aspect. Obstacles and opportunities for the Dutch and Kentucky (horticultural) industry are also described. The study provides recommendations on these aspects for follow-up activities to enable AgTech ecosystem development., Een inceptie studie is uitgevoerd van een voorgenomen haalbaarheidsstudie naar de kansen van AgTech ecosysteem ontwikkeling, in het bijzonder de glastuinbouw, in Kentucky. De huidige situatie en mogelijke vervolgstappen zijn in kaart gebracht door een ruimtelijke analyse van productielocaties voor de glastuinbouw, een markt en ketenanalyse, technische analyse van verduurzaming van de productie en het governance aspect. Tevens zijn obstakels en kansen voor het Nederlands en Kentucky (tuinbouw)bedrijfsleven beschreven. De studie levert op genoemde aspecten aanbevelingen op voor vervolg activiteiten om de AgTech ecosysteem ontwikkeling mogelijk te maken.
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- 2021
4. Regular surveillance for Li-fraumeni syndrome: advice, adherence and perceived benefits
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Lammens, C. R. M., Bleiker, E. M. A., Aaronson, N. K., Wagner, A., Sijmons, R. H., Ausems, M. G. E. M., Vriends, A. H. J. T., Ruijs, M. W. G., van Os, T. A. M., Spruijt, L., Gómez García, E. B., Cats, A., Nagtegaal, T., and Verhoef, S.
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- 2010
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5. Schadebeeld sierteelt als gevolg van coronacrisis
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Smit, P., Stokkers, R., Ruijs, M., Jukema, G., Benninga, J., Asseldonk, M. van, Smit, P., Stokkers, R., Ruijs, M., Jukema, G., Benninga, J., and Asseldonk, M. van
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- 2020
6. Abstracts of Papers presented at a Workshop on Ecology of Botrytis and Sclerotinia and their Interaction With Other Microorganisms Abstracts of Papers Presented at a Workshop on Genetic Aspects ofFusarium oxysporum and Related Species Abstracts of Papers and Discussion Contributions Presented at the Dutch-Israeli (Diarp) Workshop on Environment-Friendly Crop Protection of the Flower Industry to Suit Future Market Trends
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Ten Have, A., Breuil, W. Oude, Wubben, J., Mulder, W., Visser, J., van Kan, J., Quidde, T., Tudzynski, P., O’Neill, T. M., Meyer, G. De, Audenaert, K., Bigirimana, J., Höfte, M., Sesan, Tatiana Eugenia, Oprea, Maria, Csep, N., Procopovici, Emilia, Guran, Maria, Tica, C., Cristescu, Aurelia Podosu, Oancea, F., Elad, Y., David, D. Rav, Levi, T., Kapat, A., Kirshner, B., Govrin, E., Levine, A., Boland, G. J., O’Donnell, K., Cigelnik, E., Chiocchetti, A., Ghignone, S., Bernardo, I., Sciaudone, L., Gullino, M. L., Garibaldi, A., Migheli, Q., Kung’u, J. N., Jeffries, P., Baayen, R. P., O’Donnell, K., Waalwijk, C., Bonants, P. J. M., Cigelnik, E., Roebroeck, E. J. A., Rosewich, U. L., Pettway, R. E., Katan, Talma, Kistler, H. C., van Steekelenburg, N. A. M., Fransen, Joanne J., Ausher, R., Gokkes, M., Blind, M. P., Horowitz, A. R., Ishaaya, I., Gokkes, M., Antignus, Y., Lapidot, M., Cohen, S., Gottlieb, Y., Amsalem, D., Yad-Shalom, A., Gera, A., Dik, A. J., Kerssies, A., Bélanger, R. R., Elad, Y., Valentijn-Benz, M., Lanser, C., Elad, Y., Fischer, E., Kerssies, A., Amsing, J., Numansen, A., Paternotte, P., Runia, W., Lanser, C., van der Sar, M., Gamliel, A., Ben-Yephet, Y, Katan, J., Elad, Y, Kirshner, B., David, D. Rav, Bar-Tal, A., Silber, A., Fischer, E., Dik, A. J., Freidkin, T., Murira, Y., Gokkes, M., Kostyukovsky, M., Shaaya, E., Carmi, Y., Atzmi, Shulamit, Blind, M. P., Ausher, R., Hameiri, Y., Horowitz, A. R., Ishaaya, I., Austerweil, Miriam, de Groot, Theo, Israel, S., van der Maas, A. A., van Uffelen, R. L. M., Ammerlaan, J. C. J., van Uffelen, R. L. M., Splinter, G. M., Ammerlaan, J. C. J., Ruijs, M. N. A., and Kramer, K. -J.
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- 1999
- Full Text
- View/download PDF
7. The relation between neurological trauma parameters and long-term outcome in children with closed head injury
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Ruijs, M. B. M., Gabreëls, F. J. M., and Keyser, A.
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- 1993
- Full Text
- View/download PDF
8. Inkomensraming land- en tuinbouw 2019 - Marc Ruijs licht de glastuinbouw sector toe
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Ruijs, M. and Ruijs, M.
- Abstract
Inkomensraming land- en tuinbouw 2019 - Marc Ruijs licht de glastuinbouw sector toe. Lees meer over de inkomensraming op: https://www.wur.nl/nl/Onderzoek-Resultaten/Onderzoeksinstituten/Economic-Research/show-wecr/Gemiddeld-inkomen-land-en-tuinbouw-stijgt-licht-grote-verschillen-tussen-sectoren.htm
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- 2019
9. Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition (vol 118, pg 266, 2018)
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Mikropoulos, C., Selkirk, C.G.H., Saya, S., Bancroft, E., Vertosick, E., Dadaev, T., Brendler, C., Page, E., Dias, A., Evans, D.G., Rothwell, J., Maehle, L., Axcrona, K., Richardson, K., Eccles, D., Jensen, T., Osther, P.J., Asperen, C.J. van, Vasen, H., Kiemeney, L.A., Ringelberg, J., Cybulski, C., Wokolorczyk, D., Hart, R., Glover, W., Lam, J., Taylor, L., Salinas, M., Feliubadalo, L., Oldenburg, R., Cremers, R., Verhaegh, G., Zelst-Stams, W.A. van, Oosterwijk, J.C., Cook, J., Rosario, D.J., Buys, S.S., Conner, T., Domchek, S., Powers, J., Ausems, M.G.E.M., Teixeira, M.R., Maia, S., Izatt, L., Schmutzler, R., Rhiem, K., Foulkes, W.D., Boshari, T., Davidson, R., Ruijs, M., Helderman-van den Enden, A.T.J.M., Andrews, L., Walker, L., Snape, K., Henderson, A., Jobson, I., Lindeman, G.J., Liljegren, A., Harris, M., Adank, M.A., Kirk, J., Taylor, A., Susman, R., Chen-Shtoyerman, R., Pachter, N., Spigelman, A., Side, L., Zgajnar, J., Mora, J., Brewer, C., Gadea, N., Brady, A.F., Gallagher, D., Os, T. van, Donaldson, A., Stefansdottir, V., Barwell, J., James, P.A., Murphy, D., Friedman, E., Nicolai, N., Greenhalgh, L., Obeid, E., Murthy, V., Copakova, L., McGrath, J., Teo, S.H., Strom, S., Kast, K., Leongamornlert, D.A., Chamberlain, A., Pope, J., Newlin, A.C., Aaronson, N., Ardern-Jones, A., Bangma, C., Castro, E., Dearnaley, D., Eyfjord, J., Falconer, A., Foster, C.S., Gronberg, H., Hamdy, F.C., Johannsson, O., Khoo, V., Lubinski, J., Grindedal, E.M., McKinley, J., Shackleton, K., Mitra, A.V., Moynihan, C., Rennert, G., Suri, M., Tricker, K., Moss, S., Kote-Jarai, Z., Vickers, A., Lilja, H., Helfand, B.T., Eeles, R.A., and IMPACT Study Collaborators
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- 2018
10. Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
- Author
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Mikropoulos, C., Selkirk, C.G.H., Saya, S., Bancroft, E., Vertosick, E., Dadaev, T., Brendler, C., Page, E., Dias, A., Evans, D.G., Rothwell, J., Maehle, L., Axcrona, K., Richardson, K., Eccles, D., Jensen, T., Osther, P.J., Asperen, C.J. van, Vasen, H., Kiemeney, L.A., Ringelberg, J., Cybulski, C., Wokolorczyk, D., Hart, R., Glover, W., Lam, J., Taylor, L., Salinas, M., Feliubadalo, L., Oldenburg, R., Cremers, R., Verhaegh, G., Zelst-Stams, W.A. van, Oosterwijk, J.C., Cook, J., Rosario, D.J., Buys, S.S., Conner, T., Domchek, S., Powers, J., Ausems, M.G.E.M., Teixeira, M.R., Maia, S., Izatt, L., Schmutzler, R., Rhiem, K., Foulkes, W.D., Boshari, T., Davidson, R., Ruijs, M., Helderman-van den Enden, A.T.J.M., Andrews, L., Walker, L., Snape, K., Henderson, A., Jobson, I., Lindeman, G.J., Liljegren, A., Harris, M., Adank, M.A., Kirk, J., Taylor, A., Susman, R., Chen-Shtoyerman, R., Pachter, N., Spigelman, A., Side, L., Zgajnar, J., Mora, J., Brewer, C., Gadea, N., Brady, A.F., Gallagher, D., Os, T. van, Donaldson, A., Stefansdottir, V., Barwell, J., James, P.A., Murphy, D., Friedman, E., Nicolai, N., Greenhalgh, L., Obeid, E., Murthy, V., Copakova, L., McGrath, J., Teo, S.H., Strom, S., Kast, K., Leongamornlert, D.A., Chamberlain, A., Pope, J., Newlin, A.C., Aaronson, N., Ardern-Jones, A., Bangma, C., Castro, E., Dearnaley, D., Eyfjord, J., Falconer, A., Foster, C.S., Gronberg, H., Hamdy, F.C., Johannsson, O., Khoo, V., Lubinski, J., Grindedal, E.M., McKinley, J., Shackleton, K., Mitra, A.V., Moynihan, C., Rennert, G., Suri, M., Tricker, K., Moss, S., Kote-Jarai, Z., Vickers, A., Lilja, H., Helfand, B.T., Eeles, R.A., and IMPACT Study Collaborators
- Subjects
predictive model ,prostate cancer ,BRCA1 ,urologic and male genital diseases ,genetic predisposition ,BRCA2 ,PSA velocity - Abstract
Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. Methods: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV. Results: 1634 participants had >= 3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml(-1), PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P = 0.031) and BRCA2 status and PSAV (P = 0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers. Conclusions: PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.
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- 2018
11. Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.
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Izatt L., Davidson R., Ruijs M., Helderman-Van Den Enden A.T., Andrews L., Walker L., Snape K., Henderson A., Jobson I., Lindeman G.J., Liljegren A., Harris M., Adank M.A., Kirk J., Taylor A., Susman R., Chen-Shtoyerman R., Pachter N., Spigelman A., Side L., Zgajnar J., Mora J., Brewer C., Gadea N., Brady A.F., Gallagher D., Van Os T., Donaldson A., Stefansdottir V., Barwell J., James P.A., Murphy D., Friedman E., Nicolai N., Greenhalgh L., Obeid E., Murthy V., Copakova L., McGrath J., Teo S.-H., Strom S., Kast K., Leongamornlert D.A., Chamberlain A., Pope J., Newlin A.C., Aaronson N., Ardern-Jones A., Bangma C., Castro E., Dearnaley D., Eyfjord J., Falconer A., Foster C.S., Gronberg H., Hamdy F.C., Johannsson O., Khoo V., Lubinski J., Grindedal E.M., McKinley J., Shackleton K., Mitra A.V., Moynihan C., Rennert G., Suri M., Tricker K., Moss S., Kote-Jarai Z., Vickers A., Lilja H., Helfand B.T., Eeles R.A., Mikropoulos C., Selkirk C.G.H., Saya S., Bancroft E., Vertosick E., Dadaev T., Brendler C., Page E., Dias A., Evans D.G., Rothwell J., Maehle L., Axcrona K., Richardson K., Eccles D., Jensen T., Osther P.J., Van Asperen C.J., Vasen H., Kiemeney L.A., Ringelberg J., Cybulski C., Wokolorczyk D., Hart R., Glover W., Lam J., Taylor L., Salinas M., Feliubadalo L., Oldenburg R., Cremers R., Verhaegh G., Van Zelst-Stams W.A., Oosterwijk J.C., Cook J., Rosario D.J., Buys S.S., Conner T., Domchek S., Powers J., Ausems M.G., Teixeira M.R., Maia S., Schmutzler R., Rhiem K., Foulkes W.D., Boshari T., Izatt L., Davidson R., Ruijs M., Helderman-Van Den Enden A.T., Andrews L., Walker L., Snape K., Henderson A., Jobson I., Lindeman G.J., Liljegren A., Harris M., Adank M.A., Kirk J., Taylor A., Susman R., Chen-Shtoyerman R., Pachter N., Spigelman A., Side L., Zgajnar J., Mora J., Brewer C., Gadea N., Brady A.F., Gallagher D., Van Os T., Donaldson A., Stefansdottir V., Barwell J., James P.A., Murphy D., Friedman E., Nicolai N., Greenhalgh L., Obeid E., Murthy V., Copakova L., McGrath J., Teo S.-H., Strom S., Kast K., Leongamornlert D.A., Chamberlain A., Pope J., Newlin A.C., Aaronson N., Ardern-Jones A., Bangma C., Castro E., Dearnaley D., Eyfjord J., Falconer A., Foster C.S., Gronberg H., Hamdy F.C., Johannsson O., Khoo V., Lubinski J., Grindedal E.M., McKinley J., Shackleton K., Mitra A.V., Moynihan C., Rennert G., Suri M., Tricker K., Moss S., Kote-Jarai Z., Vickers A., Lilja H., Helfand B.T., Eeles R.A., Mikropoulos C., Selkirk C.G.H., Saya S., Bancroft E., Vertosick E., Dadaev T., Brendler C., Page E., Dias A., Evans D.G., Rothwell J., Maehle L., Axcrona K., Richardson K., Eccles D., Jensen T., Osther P.J., Van Asperen C.J., Vasen H., Kiemeney L.A., Ringelberg J., Cybulski C., Wokolorczyk D., Hart R., Glover W., Lam J., Taylor L., Salinas M., Feliubadalo L., Oldenburg R., Cremers R., Verhaegh G., Van Zelst-Stams W.A., Oosterwijk J.C., Cook J., Rosario D.J., Buys S.S., Conner T., Domchek S., Powers J., Ausems M.G., Teixeira M.R., Maia S., Schmutzler R., Rhiem K., Foulkes W.D., and Boshari T.
- Abstract
Background:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. Method(s):PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV. Result(s):1634 participants had 3/43 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml -l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers. Conclusion(s):PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.
- Published
- 2018
12. Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition (vol 118, pg 266, 2018)
- Author
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Mikropoulos, C, Selkirk, CGH, Saya, S, Bancroft, E, Vertosick, E, Dadaev, T, Brendler, C, Page, E, Dias, A, Evans, DG, Rothwell, J, Maehle, L, Axcrona, K, Richardson, K, Eccles, D, Jensen, T, Osther, PJ, van Asperen, CJ, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Hart, R, Glover, W, Lam, J, Taylor, L, Salinas, M, Feliubadalo, L, Oldenburg, R, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Cook, J, Rosario, DJ, Buys, SS, Conner, T, Domchek, S, Powers, J, Ausems, MGEM, Teixeira, MR, Maia, S, Izatt, L, Schmutzler, R, Rhiem, K, Foulkes, WD, Boshari, T, Davidson, R, Ruijs, M, Helderman-van den Enden, ATJM, Andrews, L, Walker, L, Snape, K, Henderson, A, Jobson, I, Lindeman, GJ, Liljegren, A, Harris, M, Adank, MA, Kirk, J, Taylor, A, Susman, R, Chen-Shtoyerman, R, Pachter, N, Spigelman, A, Side, L, Zgajnar, J, Mora, J, Brewer, C, Gadea, N, Brady, AF, Gallagher, D, van Os, T, Donaldson, A, Stefansdottir, V, Barwell, J, James, PA, Murphy, D, Friedman, E, Nicolai, N, Greenhalgh, L, Obeid, E, Murthy, V, Copakova, L, McGrath, J, Teo, S-H, Strom, S, Kast, K, Leongamornlert, DA, Chamberlain, A, Pope, J, Newlin, AC, Aaronson, N, Ardern-Jones, A, Bangma, C, Castro, E, Dearnaley, D, Eyfjord, J, Falconer, A, Foster, CS, Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Lubinski, J, Grindedal, EM, McKinley, J, Shackleton, K, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Tricker, K, Moss, S, Kote-Jarai, Z, Vickers, A, Lilja, H, Helfand, BT, Eeles, RA, Mikropoulos, C, Selkirk, CGH, Saya, S, Bancroft, E, Vertosick, E, Dadaev, T, Brendler, C, Page, E, Dias, A, Evans, DG, Rothwell, J, Maehle, L, Axcrona, K, Richardson, K, Eccles, D, Jensen, T, Osther, PJ, van Asperen, CJ, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Hart, R, Glover, W, Lam, J, Taylor, L, Salinas, M, Feliubadalo, L, Oldenburg, R, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Cook, J, Rosario, DJ, Buys, SS, Conner, T, Domchek, S, Powers, J, Ausems, MGEM, Teixeira, MR, Maia, S, Izatt, L, Schmutzler, R, Rhiem, K, Foulkes, WD, Boshari, T, Davidson, R, Ruijs, M, Helderman-van den Enden, ATJM, Andrews, L, Walker, L, Snape, K, Henderson, A, Jobson, I, Lindeman, GJ, Liljegren, A, Harris, M, Adank, MA, Kirk, J, Taylor, A, Susman, R, Chen-Shtoyerman, R, Pachter, N, Spigelman, A, Side, L, Zgajnar, J, Mora, J, Brewer, C, Gadea, N, Brady, AF, Gallagher, D, van Os, T, Donaldson, A, Stefansdottir, V, Barwell, J, James, PA, Murphy, D, Friedman, E, Nicolai, N, Greenhalgh, L, Obeid, E, Murthy, V, Copakova, L, McGrath, J, Teo, S-H, Strom, S, Kast, K, Leongamornlert, DA, Chamberlain, A, Pope, J, Newlin, AC, Aaronson, N, Ardern-Jones, A, Bangma, C, Castro, E, Dearnaley, D, Eyfjord, J, Falconer, A, Foster, CS, Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Lubinski, J, Grindedal, EM, McKinley, J, Shackleton, K, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Tricker, K, Moss, S, Kote-Jarai, Z, Vickers, A, Lilja, H, Helfand, BT, and Eeles, RA
- Abstract
This corrects the article DOI: 10.1038/bjc.2017.429.
- Published
- 2018
13. Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
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Mikropoulos, C, Selkirk, CGH, Saya, S, Bancroft, E, Vertosick, E, Dadaev, T, Brendler, C, Page, E, Dias, A, Evans, DG, Rothwell, J, Maehle, L, Axcrona, K, Richardson, K, Eccles, D, Jensen, T, Osther, PJ, van Asperen, CJ, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Hart, R, Glover, W, Lam, J (Jan), Taylor, L, Salinas, M, Feliubadalo, L, Oldenburg, Rogier, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Cook, J, Rosario, DJ, Buys, SS, Conner, T, Domchek, S, Powers, J, Ausems, M, Teixeira, MR, Maia, S, Izatt, L, Schmutzler, R, Rhiem, K, Foulkes, WD, Boshari, T, Davidson, R, Ruijs, M, Helderman-van d Enden, A, Andrews, L, Walker, L, Snape, K, Henderson, A, Jobson, I, Lindeman, GJ, Liljegren, A, Harris, M, Adank, MA (Muriel), Kirk, J, Taylor, A, Susman, R, Chen-Shtoyerman, R, Pachter, N, Spigelman, A, Side, L, Zgajnar, J, Mora, J, Brewer, C, Gadea, N, Brady, AF, Gallagher, D, Van Os, T, Donaldson, A, Stefansdottir, V, Barwell, J, James, PA, Murphy, D, Friedman, E, Nicolai, N, Greenhalgh, L, Obeid, E, Murthy, V, Copakova, L, McGrath, J, Teo, SH, Strom, S, Kast, K, Leongamornlert, DA, Chamberlain, A, Pope, J, Newlin, AC, Aaronson, N, Ardern-Jones, A, Bangma, C.H., Castro, E, Dearnaley, D, Eyfjord, J, Falconer, A, Foster, CS (Christopher), Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Lubinski, J, Grindedal, EM, McKinley, J, Shackleton, K, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Tricker, K, Moss, S, Kote-Jarai, Z, Vickers, A, Lilja, H, Helfand, BT, Eeles, RA, Mikropoulos, C, Selkirk, CGH, Saya, S, Bancroft, E, Vertosick, E, Dadaev, T, Brendler, C, Page, E, Dias, A, Evans, DG, Rothwell, J, Maehle, L, Axcrona, K, Richardson, K, Eccles, D, Jensen, T, Osther, PJ, van Asperen, CJ, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Hart, R, Glover, W, Lam, J (Jan), Taylor, L, Salinas, M, Feliubadalo, L, Oldenburg, Rogier, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Cook, J, Rosario, DJ, Buys, SS, Conner, T, Domchek, S, Powers, J, Ausems, M, Teixeira, MR, Maia, S, Izatt, L, Schmutzler, R, Rhiem, K, Foulkes, WD, Boshari, T, Davidson, R, Ruijs, M, Helderman-van d Enden, A, Andrews, L, Walker, L, Snape, K, Henderson, A, Jobson, I, Lindeman, GJ, Liljegren, A, Harris, M, Adank, MA (Muriel), Kirk, J, Taylor, A, Susman, R, Chen-Shtoyerman, R, Pachter, N, Spigelman, A, Side, L, Zgajnar, J, Mora, J, Brewer, C, Gadea, N, Brady, AF, Gallagher, D, Van Os, T, Donaldson, A, Stefansdottir, V, Barwell, J, James, PA, Murphy, D, Friedman, E, Nicolai, N, Greenhalgh, L, Obeid, E, Murthy, V, Copakova, L, McGrath, J, Teo, SH, Strom, S, Kast, K, Leongamornlert, DA, Chamberlain, A, Pope, J, Newlin, AC, Aaronson, N, Ardern-Jones, A, Bangma, C.H., Castro, E, Dearnaley, D, Eyfjord, J, Falconer, A, Foster, CS (Christopher), Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Lubinski, J, Grindedal, EM, McKinley, J, Shackleton, K, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Tricker, K, Moss, S, Kote-Jarai, Z, Vickers, A, Lilja, H, Helfand, BT, and Eeles, RA
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- 2018
14. Nederlandse handel in agrarische producten
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Ruijs, M., Jukema, G., Ruijs, M., and Jukema, G.
- Abstract
Agrarische export van Nederland in 2016 stijgt en het handelsoverschot neemt toe Uit ramingen1 blijkt dat de Nederlandse agrarische export, inclusief wederuitvoer, in 2016 stijgt met 4,4% naar € 85 mld. Zowel de uitvoer van Nederlandse makelij als de wederuitvoer namen toe. De import van agrarische producten stijgt minder sterk (1,6%) dan de export en komt uit op € 57,1 mld. Het aandeel van Duitsland in de totale Nederlandse agrarische export blijft in 2016 stabiel op ruim 25%. Het handelsoverschot van agrarische producten neemt toe in 2016 met € 2,7 mld. naar € 27,9 mld. en heeft hiermee een aandeel van 55% in de totale handelsbalans van Nederland. Het aandeel van agrarische producten in de totale Nederlandse exportwaarde is in 2016 gestegen met 0,8%-punten naar 19,9%. Dit is mede het gevolg van een groeiende export van landbouwproducten bij een gelijkblijvende totale Nederlandse exportwaarde. Het totale Nederlandse handelsoverschot stijgt daardoor naar verwachting in 2016 naar € 51,1 mld. (€ 44,1 mld. in 2015). Nederland blijft in 2015 na de Verenigde Staten de belangrijkste exporteur van agrarische producten in de wereld.
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- 2017
15. Delft Delta Design: The Houston Galveston Bay Region, Texas, USA
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Bedient, P.B., Berchum, E., Blackburn, J.B., De Boer, R., Van Brakel, S., Van Breukelen, M., Brody, S.D., Cao, Q., Colbert, T.M., Cunningham, S.W., Dupuits, G., Van den Ende, I., Gunnewijk, R., Heeringa, T., Hogendoorn, D., Bubu Hsun Ho, T., Huang, S.Y., Janssen, M., Karimi, I., Kelderman, R., Kok, M., Kuipers, A., Van Ledden, M., Lendering, K.T., Liao, Y.C., Liu, F., Van Loon-Steensma, J., De Milliano, A., Merrell, W.J., Meyer, V.J., Mooyaart, L., Newman, G., Stoeten, K., Rippi, K., Roukens, G., Ruijs, M., Samson, K., Schlepers, M., Slinger, J.H., Smulders, J., Van der Toorn, A., Van Boxelaere, H., De Vries, P., Wang, D., Yam, A.A., Kothuis, B.L.M., Brand, A.D., Sebastian, A.G., Nillesen, A.L., and Jonkman, S.N.
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flood risk reduction ,delta urbanism ,water governance ,Houston Galveston Bay ,Delta Interventions Studio ,multidisciplinary research ,multifunctional Flood Defenses ,Texas ,hydraulic infrastructure design - Abstract
In 2008, Hurricane Ike devastated Bolivar Peninsula, narrowly missing the more heavily industrialized and populated areas in the region. In the aftermath of the hurricane, the Severe Storm Prediction, Education and Evacuation from Disasters (SSPEED) Center at Rice University in Houston, and Texas A&M University in Galveston (TAMUG) led initiatives to propose and design flood mitigation strategies. In collaboration with TAMUG and the SSPEED Center, students and researchers at Delft University of Technology in the Netherlands have been investigating regional strategies for flood risk reduction. In this publication they and their Texas counterparts reflect on the research, design, and insight that has sprouted from this collective endeavor.
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- 2015
16. Nederlandse handelsbalans agrarische producten
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Ruijs, M., Jukema, G., Ruijs, M., and Jukema, G.
- Abstract
Uit ramingen1 blijkt dat de Nederlandse agrarische export, inclusief wederuitvoer, in 2015 stijgt met 0,9% naar € 82,4 mld. De import van agrarische producten zal sterker stijgen (5,9%) dan de export en komt uit op € 56,1 mld. Het aandeel van Duitsland in de totale Nederlandse agrarische export in 2015 daalt met 0,1% naar 25,3%. Het totale Nederlandse handelsoverschot daalt naar verwachting in 2015 naar € 46,3 mld. (€ 51 mld. in 2014). Het handelsoverschot van agrarische producten neemt in 2015 af met € 2,4 mld. naar € 26,4 mld.
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- 2016
17. Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study
- Author
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Bancroft, EK, Page, EC, Castro, E, Lilja, H, Vickers, A, Sjoberg, D, Assel, M, Foster, CS, Mitchell, G, Drew, K, Maehle, L, Axcrona, K, Evans, DG, Bulman, B, Eccles, D, McBride, D, van Asperen, C, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Selkirk, C, Hulick, PJ, Bojesen, A, Skytte, AB, Lam, J, Taylor, L, Oldenburg, R, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Blanco, I, Salinas, M, Cook, J, Rosario, DJ, Buys, S, Conner, T, Ausems, MG, Ong, KR, Hoffman, J, Domchek, S, Powers, J, Teixeira, MR, Maia, S, Foulkes, WD, Taherian, N, Ruijs, M, Helderman-van den Enden, AT, Izatt, L, Davidson, R, Adank, MA, Walker, L, Schmutzler, R, Tucker, K, Kirk, J, Hodgson, S, Harris, M, Douglas, F, Lindeman, GJ, Zgajnar, J, Tischkowitz, M, Clowes, VE, Susman, R, Cajal, TRY, Patcher, N, Gadea, N, Spigelman, A, van Os, T, Liljegren, A, Side, L, Brewer, C, Brady, AF, Donaldson, A, Stefansdottir, V, Friedman, E, Chen-Shtoyerman, R, Amor, DJ, Copakova, L, Barwell, J, Giri, VN, Murthy, V, Nicolai, N, Teo, SH, Greenhalgh, L, Strom, S, Henderson, A, McGrath, J, Gallagher, D, Aaronson, N, Ardern-Jones, A, Bangma, C, Dearnaley, D, Costello, P, Eyfjord, J, Rothwell, J, Falconer, A, Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Kote-Jarai, Z, Lubinski, J, Axcrona, U, Melia, J, McKinley, J, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Wilson, P, Killick, E, Moss, S, Eeles, RA, Taylor, N, Pope, J, Saya, S, Martin, S, Keating, D, Petelin, L, Murphy, M, Doherty, R, Pratt, S, Murphy, D, Cleeve, L, Miller, C, Stapleton, A, Chong, M, Suthers, G, Andrews, L, Duffy, J, Millard, R, Ward, R, Williams, R, Stricker, P, Bowman, M, Patel, M, O'Connell, S, Hunt, C, Smyth, C, Frydenberg, M, Shackleton, K, McGaughran, J, Boon, M, Pachter, N, Townshend, S, Schofield, L, Gleeson, M, Scott, R, Burke, J, Patterson, B, Bacic, S, Swindle, P, Aprikian, A, Bojeson, A, Cruger, D, Osther, P, Gerdes, AM, Rhiem, K, Luedtke-Heckenkamp, K, Ochsendorf, N, Fiddike, K, Sarin, R, Awatagiri, K, Ghonge, S, Kowtal, P, Mulgund, G, Bambury, R, Farrell, M, Gallagher, F, Ben-Yehoshua, SJ, Nissani, R, Appelman, Z, Moriel, E, Radice, P, Valdagni, R, Magnani, T, Meng, TH, Yoon, SY, Thong, MK, Kiemeney, B, Van der Luijt, RB, Moller, P, Brennhovd, B, Medvik, H, Hanslien, E, Peixoto, A, Henrique, R, Oliveira, J, Goncalves, N, Araujo, L, Seixas, M, Joao, PS, Nogueira, P, Krajc, M, Vrecar, A, Capella, G, Fisas, D, Balmana, J, Morote, J, Hjalm-Eriksson, M, Ekdahl, KJ, Carlsson, S, Hanson, H, Shanley, S, Goh, C, Wiggins, J, Kohut, K, Van As, N, Thompson, A, Ogden, C, Borley, N, Woodhouse, C, Kumar, P, Mercer, C, Paterson, J, Taylor, A, Newcombe, B, Halliday, D, Stayner, B, Fleming-Brown, D, Brice, G, Homfray, T, Hammond, C, Potter, A, Renton, C, Searle, A, Hill, K, Goodman, S, Garcia, L, Devlin, G, Everest, S, Nadolski, M, Jobson, I, Paez, E, Tomkins, S, Pichert, G, Jacobs, C, Langman, C, Weston, M, Dorkins, H, Melville, A, Kosicka-Slawinska, M, Cummings, C, Kiesel, V, Bartlett, M, Randhawa, K, Ellery, N, Male, A, Simon, K, Rees, K, Compton, C, Tidey, L, Nevitt, L, Ingram, S, Catto, J, Howson, J, Chapman, C, Cole, T, Heaton, T, Burgess, L, Longmuir, M, Watt, C, Duncan, A, Kockelbergh, R, Sattar, A, Kaemba, B, Sidat, Z, Patel, N, Siguake, K, Birt, A, Poultney, U, Umez-Eronini, N, Mom, J, Roberts, G, Woodward, A, Sutton, V, Cornford, P, Treherne, K, Griffiths, J, Cogley, L, Rubinstein, W, Brendler, C, Helfand, B, McGuire, M, Kaul, K, Shevrin, D, Weissman, S, Newlin, A, Vogel, K, Weiss, S, Goldgar, D, Venne, V, Stephenson, R, Dechet, C, Arun, B, Davis, JW, Yamamura, Y, and Gross, L
- Subjects
Prostate cancer ,BRCA1 ,BRCA2 ,Prostate-specific antigen ,Targeted screening - Abstract
Background: Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations. Objective: To report the first year's screening results for all men at enrolment in the study. Design, setting and participants: We recruited men aged 40-69 yr with germline BRCA1/2 mutations and a control group of men who have tested negative for a pathogenic BRCA1 or BRCA2 mutation known to be present in their families. All men underwent prostate-specific antigen (PSA) testing at enrolment, and those men with PSA > 3 ng/ml were offered prostate biopsy. Outcome measurements and statistical analysis: PSA levels, PCa incidence, and tumour characteristics were evaluated. The Fisher exact test was used to compare the number of PCa cases among groups and the differences among disease types. Results and limitations: We recruited 2481 men (791 BRCA1 carriers, 531 BRCA1 controls; 731 BRCA2 carriers, 428 BRCA2 controls). A total of 199 men (8%) presented with PSA > 3.0 ng/ml, 162 biopsies were performed, and 59 PCas were diagnosed (18 BRCA1 carriers, 10 BRCA1 controls; 24 BRCA2 carriers, 7 BRCA2 controls); 66% of the tumours were classified as intermediate-or high-risk disease. The positive predictive value (PPV) for biopsy using a PSA threshold of 3.0 ng/ml in BRCA2 mutation carriers was 48%-double the PPV reported in population screening studies. A significant difference in detecting intermediate-or high-risk disease was observed in BRCA2 carriers. Ninety-five percent of the men were white, thus the results cannot be generalised to all ethnic groups. Conclusions: The IMPACT screening network will be useful for targeted PCa screening studies in men with germline genetic risk variants as they are discovered. These preliminary results support the use of targeted PSA screening based on BRCA genotype and show that this screening yields a high proportion of aggressive disease. Patient summary: In this report, we demonstrate that germline genetic markers can be used to identify men at higher risk of prostate cancer. Targeting screening at these men resulted in the identification of tumours that were more likely to require treatment. (C) 2014 European Association of Urology. Published by Elsevier B. V. All rights reserved.
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- 2014
18. Performance of BRCA1/2 mutation prediction models in male breast cancer patients.
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Moghadasi, S., Grundeken, V., Janssen, L. A. M., Dijkstra, N. H., Rodríguez‐Girondo, M., van Zelst‐Stams, W. A. G., Oosterwijk, J. C., Ausems, M. G. E. M., Oldenburg, R. A., Adank, M. A., Blom, E. W., Ruijs, M. W. G., van Os, T. A. M., van Deurzen, C. H. M., Martens, J. W. M., Schroder, C. P., Wijnen, J. T., Vreeswijk, M. P. G., and van Asperen, C. J.
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GENETIC mutation ,BREAST cancer patients ,BREAST cancer ,CANCER prevention ,DISEASE incidence ,BREAST cancer treatment - Abstract
To establish whether existing mutation prediction models can identify which male breast cancer ( MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm), BRCAPRO (BRCA probability) and the Myriad prevalence table ('Myriad'). These models were evaluated using the family data of 307 Dutch MBC probands tested for BRCA1/2, 58 (19%) of whom were carriers. We compared the numbers of observed vs predicted carriers and assessed the Area Under the Receiver Operating Characteristic ( ROC) Curve ( AUC) for each model. BOADICEA predicted the total number of BRCA1/2 mutation carriers quite accurately (observed/predicted ratio: 0.94). When a cut-off of 10% and 20% prior probability was used, BRCAPRO showed a non-significant better performance (observed/predicted ratio BOADICEA: 0.81, 95% confidence interval [ CI]: [0.60-1.09] and 0.79, 95% CI: [0.57-1.09], vs. BRCAPRO: 1.02, 95% CI: [0.75-1.38] and 0.94, 95% CI: [0.68-1.31], respectively). Myriad underestimated the number of carriers in up to 69% of the cases. BRCAPRO showed a non-significant, higher AUC than BOADICEA (0.798 vs 0.776). Myriad showed a significantly lower AUC (0.671). BRCAPRO and BOADICEA can efficiently identify MBC patients as BRCA1/2 mutation carriers. Besides their general applicability, these tools will be of particular value in countries with limited healthcare resources. [ABSTRACT FROM AUTHOR]
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- 2018
- Full Text
- View/download PDF
19. Verkassen? Maatschappelijke kosten en baten van het verplaatsen van tuinbouw ten behoeve van woningbouw
- Author
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Koopmans, C., van der Knijff, A., Marlet, G., Ruijs, M., Smit, P., Stokkers, R., Willebrands, D., van Woerkens, C., Spatial Economics, Economics, and SEO Economisch Onderzoek
- Subjects
LEI SECT & OND - Duurzame Ontwikkeling Agrosectoren ,LEI Sector & Ondernemerschap ,Wageningen UR Greenhouse Horticulture ,tuinbouw ,horticulture ,ornamental bulbs ,westland ,bollenstreek ,land use planning ,bloembollen ,location of production ,LEI SECT & OND - Prestatie en Perspectief Agrosectoren ,Wageningen UR Glastuinbouw ,landgebruiksplanning ,LEI Agricultural sector & entrepreneurship ,cost benefit analysis ,glastuinbouw ,vestigingsplaats van de productie ,kosten-batenanalyse ,greenhouse horticulture - Abstract
Het bouwen van woningen in de Bollenstreek is maatschappelijk rendabel als de bollenteelt geleidelijk wordt verplaatst naar elders in Nederland. Woningbouw in het Westland is mogelijk rendabel als het om extra woningen gaat. Dat blijkt uit een kengetallen kosten-batenanalyse (KKBA) van een toekomst waarin in 2040 een kwart van deze huidige ‘greenports’ wordt gebruikt voor woningbouw. Het onderzoek is uitgevoerd in samenwerking met het LEI en Atlas voor gemeenten. Zowel bij de tuinbouw als bij woningen geldt dat het voordelig is om dicht bij elkaar te zitten. Tuinbouwbedrijven profiteren van elkaars nabijheid door de aanwezigheid van voorzieningen, toe-leveranciers en kennis: de zogenaamde clustereffecten. Waar veel woningen geconcentreerd zijn in agglomeraties, ontstaan voordelen voor bedrijven en consumenten: meer keuze uit werknemers en klanten enerzijds, en meer keuze uit voorzieningen anderzijds. Dit komt tot uiting in de lonen en de woningprijzen. Door de ligging van de greenports nabij de grote steden in de Randstad, zullen naar verwachting de agglomeratie effecten van de woningbouw op deze locaties aanzienlijk zijn. Het onderzoek analyseert of deze agglomeratie baten opwegen tegen het verlies aan clustereffecten en de kosten van verplaatsing van de tuinbouw. Daarnaast zijn gevolgen voor open ruimte en natuur meegenomen, via hun invloed op de prijzen van woningen. Verplaatsing vanuit de Bollenstreek brengt aanzienlijk minder kosten met zich mee dan verplaatsing vanuit het Westland. Dit hangt samen met de extra investeringen in kassen en infrastructuur die gepaard gaan met verplaatsing van glastuinbouw. De woningbouwbaten van verplaatsing zijn bovendien per hectare en per woning groter in de Bollenstreek. De kosten en baten laten daardoor in de Bollenstreek een positiever beeld zien dan in het Westland. Bovendien kan in de Bollenstreek ook worden gekozen om deels weiland te gebruiken in plaats van tuinbouwgrond.
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- 2011
20. Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study
- Author
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Bancroft, E.K., Page, E.C., Castro, E., Lilja, H., Vickers, A., Sjoberg, D., Assel, M., Foster, C.S., Mitchell, G., Drew, K., Maehle, L., Axcrona, K., Evans, D.G., Bulman, B., Eccles, D., McBride, D., Asperen, C. van, Vasen, H., Kiemeney, B., Ringelberg, J., Cybulski, C., Wokolorczyk, D., Selkirk, C., Hulick, P.J., Bojesen, A., Skytte, A.B., Lam, J., Taylor, L., Oldenburg, R., Cremers, R., Verhaegh, G., Zelst-Stams, W.A.G. van, Oosterwijk, J.C., Blanco, I., Salinas, M., Cook, J., Rosario, D.J., Buys, S., Conner, T., Ausems, M.G., Ong, K.R., Hoffman, J., Domchek, S., Powers, J., Teixeira, M.R., Maia, S., Foulkes, W.D., Taherian, N., Ruijs, M., Enden, A.T. den, Izatt, L., Davidson, R., Adank, M.A., Walker, L., Schmutzler, R., Tucker, K., Kirk, J., Hodgson, S., Harris, M., Douglas, F., Lindeman, G.J., Zgajnar, J., Tischkowitz, M., Clowes, V.E., Susman, R., Ramon, Y.C.T., Patcher, N., Gadea, N., Spigelman, A., Os, T. van, Liljegren, A., Side, L., Brewer, C., Brady, A.F., Donaldson, A., Stefansdottir, V., Friedman, E., Chen-Shtoyerman, R., Amor, D.J., Copakova, L., Barwell, J., Giri, V.N., Murthy, V., Nicolai, N., Teo, S.H., Greenhalgh, L., Strom, S., Henderson, A., McGrath, J., Gallagher, D., Aaronson, N., Ardern-Jones, A., Bangma, C., Dearnaley, D., Costello, P., Eyfjord, J., Rothwell, J., Falconer, A., Gronberg, H., Hamdy, F.C., Bancroft, E.K., Page, E.C., Castro, E., Lilja, H., Vickers, A., Sjoberg, D., Assel, M., Foster, C.S., Mitchell, G., Drew, K., Maehle, L., Axcrona, K., Evans, D.G., Bulman, B., Eccles, D., McBride, D., Asperen, C. van, Vasen, H., Kiemeney, B., Ringelberg, J., Cybulski, C., Wokolorczyk, D., Selkirk, C., Hulick, P.J., Bojesen, A., Skytte, A.B., Lam, J., Taylor, L., Oldenburg, R., Cremers, R., Verhaegh, G., Zelst-Stams, W.A.G. van, Oosterwijk, J.C., Blanco, I., Salinas, M., Cook, J., Rosario, D.J., Buys, S., Conner, T., Ausems, M.G., Ong, K.R., Hoffman, J., Domchek, S., Powers, J., Teixeira, M.R., Maia, S., Foulkes, W.D., Taherian, N., Ruijs, M., Enden, A.T. den, Izatt, L., Davidson, R., Adank, M.A., Walker, L., Schmutzler, R., Tucker, K., Kirk, J., Hodgson, S., Harris, M., Douglas, F., Lindeman, G.J., Zgajnar, J., Tischkowitz, M., Clowes, V.E., Susman, R., Ramon, Y.C.T., Patcher, N., Gadea, N., Spigelman, A., Os, T. van, Liljegren, A., Side, L., Brewer, C., Brady, A.F., Donaldson, A., Stefansdottir, V., Friedman, E., Chen-Shtoyerman, R., Amor, D.J., Copakova, L., Barwell, J., Giri, V.N., Murthy, V., Nicolai, N., Teo, S.H., Greenhalgh, L., Strom, S., Henderson, A., McGrath, J., Gallagher, D., Aaronson, N., Ardern-Jones, A., Bangma, C., Dearnaley, D., Costello, P., Eyfjord, J., Rothwell, J., Falconer, A., Gronberg, H., and Hamdy, F.C.
- Abstract
Contains fulltext : 136921.pdf (publisher's version ) (Closed access), BACKGROUND: Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations. OBJECTIVE: To report the first year's screening results for all men at enrolment in the study. DESIGN, SETTING AND PARTICIPANTS: We recruited men aged 40-69 yr with germline BRCA1/2 mutations and a control group of men who have tested negative for a pathogenic BRCA1 or BRCA2 mutation known to be present in their families. All men underwent prostate-specific antigen (PSA) testing at enrolment, and those men with PSA >3 ng/ml were offered prostate biopsy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: PSA levels, PCa incidence, and tumour characteristics were evaluated. The Fisher exact test was used to compare the number of PCa cases among groups and the differences among disease types. RESULTS AND LIMITATIONS: We recruited 2481 men (791 BRCA1 carriers, 531 BRCA1 controls; 731 BRCA2 carriers, 428 BRCA2 controls). A total of 199 men (8%) presented with PSA >3.0 ng/ml, 162 biopsies were performed, and 59 PCas were diagnosed (18 BRCA1 carriers, 10 BRCA1 controls; 24 BRCA2 carriers, 7 BRCA2 controls); 66% of the tumours were classified as intermediate- or high-risk disease. The positive predictive value (PPV) for biopsy using a PSA threshold of 3.0 ng/ml in BRCA2 mutation carriers was 48%-double the PPV reported in population screening studies. A significant difference in detecting intermediate- or high-risk disease was observed in BRCA2 carriers. Ninety-five percent of the men were white, thus the results cannot be generalised to all ethnic groups. CONCLUSIONS: The IMPACT screening network will be useful
- Published
- 2014
21. Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: Results from the initial screening round of the IMPACT study.
- Author
-
Domchek S., Blanco I., Salinas M., Cook J., Rosario D.J., Buys S., Conner T., Ausems M.G., Ong K.-R., Hoffman J., Powers J., Teixeira M.R., Maia S., Foulkes W.D., Taherian N., Ruijs M., Den Enden A.T.H.-V., Izatt L., Davidson R., Adank M.A., Walker L., Schmutzler R., Tucker K., Kirk J., Hodgson S., Harris M., Douglas F., Lindeman G.J., Zgajnar J., Tischkowitz M., Clowes V.E., Susman R., Ramon Y Cajal T., Patcher N., Gadea N., Spigelman A., Van Os T., Liljegren A., Side L., Brewer C., Brady A.F., Donaldson A., Stefansdottir V., Friedman E., Chen-Shtoyerman R., Amor D.J., Copakova L., Barwell J., Giri V.N., Murthy V., Nicolai N., Teo S.-H., Greenhalgh L., Strom S., Henderson A., McGrath J., Gallagher D., Aaronson N., Ardern-Jones A., Bangma C., Dearnaley D., Costello P., Eyfjord J., Rothwell J., Falconer A., Gronberg H., Hamdy F.C., Johannsson O., Khoo V., Kote-Jarai Z., Lubinski J., Axcrona U., Melia J., McKinley J., Mitra A.V., Moynihan C., Rennert G., Suri M., Wilson P., Killick E., Moss S., Eeles R.A., Bancroft E.K., Page E.C., Castro E., Lilja H., Vickers A., Sjoberg D., Assel M., Foster C.S., Mitchell G., Drew K., Maehle L., Axcrona K., Evans D.G., Bulman B., Eccles D., McBride D., Van Asperen C., Vasen H., Kiemeney L.A., Ringelberg J., Cybulski C., Wokolorczyk D., Selkirk C., Hulick P.J., Bojesen A., Skytte A.-B., Lam J., Taylor L., Oldenburg R., Cremers R., Verhaegh G., Van Zelst-Stams W.A., Oosterwijk J.C., Domchek S., Blanco I., Salinas M., Cook J., Rosario D.J., Buys S., Conner T., Ausems M.G., Ong K.-R., Hoffman J., Powers J., Teixeira M.R., Maia S., Foulkes W.D., Taherian N., Ruijs M., Den Enden A.T.H.-V., Izatt L., Davidson R., Adank M.A., Walker L., Schmutzler R., Tucker K., Kirk J., Hodgson S., Harris M., Douglas F., Lindeman G.J., Zgajnar J., Tischkowitz M., Clowes V.E., Susman R., Ramon Y Cajal T., Patcher N., Gadea N., Spigelman A., Van Os T., Liljegren A., Side L., Brewer C., Brady A.F., Donaldson A., Stefansdottir V., Friedman E., Chen-Shtoyerman R., Amor D.J., Copakova L., Barwell J., Giri V.N., Murthy V., Nicolai N., Teo S.-H., Greenhalgh L., Strom S., Henderson A., McGrath J., Gallagher D., Aaronson N., Ardern-Jones A., Bangma C., Dearnaley D., Costello P., Eyfjord J., Rothwell J., Falconer A., Gronberg H., Hamdy F.C., Johannsson O., Khoo V., Kote-Jarai Z., Lubinski J., Axcrona U., Melia J., McKinley J., Mitra A.V., Moynihan C., Rennert G., Suri M., Wilson P., Killick E., Moss S., Eeles R.A., Bancroft E.K., Page E.C., Castro E., Lilja H., Vickers A., Sjoberg D., Assel M., Foster C.S., Mitchell G., Drew K., Maehle L., Axcrona K., Evans D.G., Bulman B., Eccles D., McBride D., Van Asperen C., Vasen H., Kiemeney L.A., Ringelberg J., Cybulski C., Wokolorczyk D., Selkirk C., Hulick P.J., Bojesen A., Skytte A.-B., Lam J., Taylor L., Oldenburg R., Cremers R., Verhaegh G., Van Zelst-Stams W.A., and Oosterwijk J.C.
- Abstract
Background Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations. Objective To report the first year's screening results for all men at enrolment in the study. Design, setting and participants We recruited men aged 40-69 yr with germline BRCA1/2 mutations and a control group of men who have tested negative for a pathogenic BRCA1 or BRCA2 mutation known to be present in their families. All men underwent prostate-specific antigen (PSA) testing at enrolment, and those men with PSA >3 ng/ml were offered prostate biopsy. Outcome measurements and statistical analysis PSA levels, PCa incidence, and tumour characteristics were evaluated. The Fisher exact test was used to compare the number of PCa cases among groups and the differences among disease types. Results and limitations We recruited 2481 men (791 BRCA1 carriers, 531 BRCA1 controls; 731 BRCA2 carriers, 428 BRCA2 controls). A total of 199 men (8%) presented with PSA >3.0 ng/ml, 162 biopsies were performed, and 59 PCas were diagnosed (18 BRCA1 carriers, 10 BRCA1 controls; 24 BRCA2 carriers, 7 BRCA2 controls); 66% of the tumours were classified as intermediate- or high-risk disease. The positive predictive value (PPV) for biopsy using a PSA threshold of 3.0 ng/ml in BRCA2 mutation carriers was 48% - double the PPV reported in population screening studies. A significant difference in detecting intermediate- or high-risk disease was observed in BRCA2 carriers. Ninety-five percent of the men were white, thus the results cannot be generalised to all ethnic groups. Conclusions The IMPACT screening network will be useful for
- Published
- 2014
22. Praktijkevaluatie levert waarheden, onderzoek levert verwachtingen; Verkenning Praktijkevaluatie van toegepaste energiebesparingstechnieken in de glastuinbouw
- Author
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Ravensbergen, P. and Ruijs, M.
- Subjects
Wageningen Economic Research ,energy conservation ,evaluation ,energiebehoud ,tuinbouw ,horticulture ,glastuinbouw ,evaluatie ,landbouwkundig onderzoek ,agricultural research ,greenhouse horticulture - Published
- 2001
23. Recreatie & toerisme : zand én veen
- Author
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Kamperman, G., Ruijs, M., Kamperman, G., and Ruijs, M.
- Abstract
In dit rapport wordt enerzijds een theoretisch kader geschetst om een visie voor het buitengebied te vormen. Anderzijds wordt praktisch een suggestie gedaan om de ruimtelijke recreatieve verbinding van zand naar veen tot stand te brengen. En wel binnen de gemeente Twenterand. In samenwerking met Groen Kennispoort Twente. Het landschapsontwikkelingsplan is daarbij richtinggevend.
- Published
- 2012
24. Problemen en uitdagingen voor de glastuinbouw in Nederland
- Author
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Hietbrink, O., Ploeger, C., Alleblas, J., Ruijs, M., van Uffelen, R., and Annevelink, E.
- Subjects
Institute of Agricultural and Environmental Engineering ,Instituut voor Mechanisatie, Arbeid en Gebouwen ,Life Science - Published
- 2000
25. The Effects of the 'Ike Dike' barriers on Galveston Bay
- Author
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Ruijs, M. (author) and Ruijs, M. (author)
- Abstract
In 2008 Hurricane Ike flooded large parts of the barrier islands in front of the Galveston Bay near Houston, Texas. The storm surge also entered the bay through the inlets causing great damage along the bay and the port of Houston. Because of the high probability that a hurricane would strike again the “Ike Dike” was developed. The concept consists of heightening and extending the floodwall on Galveston Island and Bolivar Peninsula. Barriers will be placed at the San Luis Pass and Bolivar Roads inlet whereas the Rollover Pass might be closed completely. The Bolivar Roads barrier will be a combination between a floodgate and a lifting gate structure. During non-storm conditions, when the gates are open, the flow area through the inlets are expected to reduce up to 40-60% due to the barriers. The reduction of flow area can cause a decrease of the tidal prism and tidal range. Also current velocities are expected to increase near the barriers and decrease in the main bay. The residence time of fresh water in the bay is expected to increase and the salinity to decrease. The reduction of the tidal prism, tidal range and current speeds can cause a redistribution of the sediment from marshes and flats to the channels within the bay. The blocking of sediment from the Mexican Gulf by the barriers can further enhance this. Changes of the hydrodynamics, water quality and morphology in the bay could potentially result in loss of habitat and disturb the ecology. A 2D hydrodynamic model has been created in order to investigate the impact of the barriers on the tidal prism, tidal range and circulation in the bay. The morphology and water quality of the bay are investigated qualitatively using literature, reference projects and the outcomes of the 2D model. It is concluded that a 40-60% decrease of the flow area at the Bolivar Roads entrance affects the hydrodynamics of the Galveston Bay. To mitigate or prevent these effects the design could be altered such that the flow area is red, Coastal Engineering, Hydraulic Engineering, Civil Engineering and Geosciences
- Published
- 2011
26. Economie van Het Nieuwe Telen
- Author
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Ruijs, M., Vermeulen, P., Ruijs, M., and Vermeulen, P.
- Abstract
Powerpointpresentatie over het economisch perspectief van geconditioneerd telen op korte en langere termijn, een inventarisatie systeemvarianten in praktijk en onderzoek, focus op systeemvarianten van Het Nieuwe Telen (HTN) en recente resultaten in praktijk en onderzoek.
- Published
- 2010
27. Jetty design at Rio Araranguá
- Author
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Van der Woerdt, W. (author), Van den Bosch, I. (author), Heerema, R. (author), Ruijs, M. (author), Van der Woerdt, W. (author), Van den Bosch, I. (author), Heerema, R. (author), and Ruijs, M. (author)
- Abstract
Master project report. The hydraulic efficiency of the river Araranguá will be increased by the construction of jetties at the mouth of the river. The river tends to migrate from south to north which decreases the hydraulic efficiency and causes flooding upstream during events of high discharge. To stop the migration the construction of jetties at the mouth of river Araranguá is proposed. A design for a jetty system is available (INHP, 1993), but should be updated. Due to the construction of a jetty system longshore sediment transport will be interrupted and this will cause morphological changes. At Araranguá river a large and highly varying longshore sediment transport is present with a high energy wave climate and micro tidal range. These conditions cause increased morphological changes when constructing a jetty system. The objective of this research is to design a jetty system that prevents flooding upstream and induces as less morphological changes as possible. The jetty should be designed at the specified location, using available datasets from previous research and according to modern design standards. Also navigation through the channel should be possible. The channel width and depth are determined by navigational and morphological purposes and are 120 m and 6 m respectively. A weir jetty, which has been implemented in the SW arm of the design, was considered the best sediment bypass system after a multi criteria analysis. Because of the placing of the deposition basin waves could penetrate much further in the jetty channel and lengthening the NE arm to 630 m and a depth of 6,6 m was necessary. The length of the SW arm of the jetty from the previous is kept at 650 meter to a depth of 7,2 meter. The final result of the structural design is a statically stable rubble mound breakwater with granite as construction material. Rock has been applied in the range of 0,4 m (170 kg) to 1,0 m (2,7 tons) in diameter, with a core of quarry run material. In sections where t, Hydraulic Engineering, Civil Engineering and Geosciences
- Published
- 2009
28. Attitude towards pre-implantation genetic diagnosis for hereditary cancer
- Author
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Lammens, C, Bleiker, E, Aaronson, N, Vriends, A, Ausems, M, Jansweijer, M, Wagner, Anja, Sijmons, R, van den Ouweland, Ans, van der Luijt, R, Spruijt, L, Garcia, EG, Ruijs, M, Verhoef, S, Lammens, C, Bleiker, E, Aaronson, N, Vriends, A, Ausems, M, Jansweijer, M, Wagner, Anja, Sijmons, R, van den Ouweland, Ans, van der Luijt, R, Spruijt, L, Garcia, EG, Ruijs, M, and Verhoef, S
- Abstract
The use of pre-implantation genetic diagnosis (PGD) for hereditary cancer is subject to on-going debate, particularly among professionals. This study evaluates the attitude towards PGD and attitude-associated characteristics of those concerned: family members with a hereditary cancer predisposition. Forty-eight Von Hippel-Lindau and 18 Li-Fraumeni Syndrome families were identified via the 9 family cancer clinics in the Netherlands. In total, 216 high risk family members and partners were approached, of whom 179 (83%) completed a self-report questionnaire. Of the high risk family members, 35% expressed a positive attitude towards PGD. Those with a current desire to have children were significantly more likely to have a positive attitude: 48% would consider the use of PGD. No other sociodemographic, medical or psychosocial variables were associated significantly with a positive attitude. The most frequently reported advantage of PGD is the avoidance of a possible pregnancy termination. Uncertainty about late effects was the most frequently reported disadvantage. These results indicate that approximately half of those contemplating a future pregnancy would consider the use of PGD. The actual uptake, however, is expected to be lower. There is no indication that psychosocial factors affect interest in PGD.
- Published
- 2009
29. Reducing the need for external inputs in high value protected horticultural and ornamental crops : Seventh Framework Programme theme KBBE-2007-1-2-04 : WP1 environmental and economic assessment
- Author
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Ruijs, M. and Ruijs, M.
- Abstract
Powerpointpresentatie.
- Published
- 2009
30. Economie van Het Nieuwe Telen : Horti Fair breakfastbriefing 2009
- Author
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Ruijs, M., Raaphorst, M., Ruijs, M., and Raaphorst, M.
- Abstract
Powepointpresentatie over Het Nieuwe Telen (HNT) in de tuinbouw, waarbij aandacht voor de studie economisch perspectief van geconditioneerd telen op korte en langere termijn. een inventarisatie systeemvarianten in praktijk en onderzoek, veel verschillende systeemvarianten, de focus op systeemvarianten van Het Nieuwe telen en de basis: recente resultaten in praktijk en onderzoek.
- Published
- 2009
31. Van klimaatregeling naar plantsturing
- Author
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Huevelink, E., Kempkes, F., Marcelis, L., Bakker, M., Campen, J., Dieleman, A., Maas, F., Garcia, N., Noort, F. van, Ruijs, M., Veenman, J., Huevelink, E., Kempkes, F., Marcelis, L., Bakker, M., Campen, J., Dieleman, A., Maas, F., Garcia, N., Noort, F. van, Ruijs, M., and Veenman, J.
- Abstract
Powerpointpresentatie over de doelstellingen van de teelt, de kasklimaatregeling, horzontale en verticale verschillen in de kas, NIR reflectie en luchtcirculatie.
- Published
- 2009
32. Samen zoeken naar lange termijn oplossingen voor de biologische glastuinbouw
- Author
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Blom, G., Janmaat, L., Os, E. Van, Ruijs, M., Blom, G., Janmaat, L., Os, E. Van, and Ruijs, M.
- Abstract
De prestaties van de biologische glastuinbouw op het gebied van energieverbruik, uitspoeling van mineralen naar het grond- en oppervlaktewater en de onderdrukking van (bodemgebonden) ziekten en plagen zijn nog zeer onvoldoende. De biologische sector wordt echter geacht een koppositie in te nemen op het gebied van duurzaamheid. Dit vraagt grote innovatieve stappen op diverse terreinen. In deze publicatie worden een aantal toekomstbeelden besproken, zoals de Bioproductiekas en de Biostadskas. Voor belangrijke knelpunten binnen de bodemproblematiek zijn een aantal korte en lange termijn oplossingsrichtlijnen gedefinieerd. Een belangrijke conclusie is, dat de huidige teeltwijze met een eenzijdige jaarrondteelt een risicovol en kwetsbaar teeltsysteem is. Omschakeling naar ruime vruchtwisseling en inbouw van rustperioden is voor telers nog onhaalbaar. Innovaties die hiervoor nodig zijn worden momenteel getest in projecten als Biowisselkas en Biobodemvitaalkas.
- Published
- 2008
33. Kansen voor glastuinbouwcomplex Terneuzen?
- Author
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Ruijs, M. and Ruijs, M.
- Abstract
Bij Terneuzen (Westdorpe) is een projectlocatie glastuinbouw (LOG) voorzien van 215 ha. Het LEI heeft in het kader van het Transforum Agro en Groen-project ‘Ontwikkeling van een Agribusiness cluster in de kanaalzone Gent Terneuzen’ onderzocht wat de betekenis is van de huidige glastuinbouwketen in en rondom Terneuzen en welke kansen LOG Terneuzen biedt om uit te groeien tot een toekomstig glastuinbouwcomplex. Wel staan alle overheden positief tegenover de komst van glastuinbouw en zijn er op koter termijn grote kavels beschikbaar.
- Published
- 2008
34. Rentabiliteit geconditioneerd telen, 2 april 2008
- Author
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Raaphorst, M., Ruijs, M., Raaphorst, M., and Ruijs, M.
- Abstract
Powerpoint-presentatie over de rentabiliteit van het geconditioneerde telen met aandacht voor achtergrond, systemen en technische uitvoeringen, economische aspecten, huidige inzichten en kansen
- Published
- 2008
35. Energiekengetallen 1996 : groeianalyse
- Author
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Vermeulen, P. and Ruijs, M.
- Subjects
Proefstation voor Bloemisterij en Glasgroente ,chrysanthemum ,data analysis ,gewassen ,crops ,gegevensanalyse ,energiegebruik ,roses ,komkommers ,cucumbers ,energy consumption ,rozen ,glastuinbouw ,tomaten ,capsicum ,tomatoes ,greenhouse horticulture - Abstract
In dit onderzoek is op basis van door tuinders geregistreerde gegevens de omvang van het energieverbruik en de verschillen daarin geanalyseerd voor de gewassen paprika, tomaat, komkommer, chrysant en roos. Hierbij is gebruik gemaakt van de energiegegevens van 1996 van MPS en de energiegegevens van deelnemers van MBT, die hiervoor toestemming hebben gegeven.
- Published
- 1998
36. Productiesystemen met teeltwisseling voor de biologische glasteelt : gebruiksmogelijkheden en perspectief : een eerste verkenning
- Author
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Blom, G., Janmaat, L., Os, E. Van, Ruijs, M., Blom, G., Janmaat, L., Os, E. Van, and Ruijs, M.
- Abstract
In het kader van het project Biologische Kringloopkas is in 2007 uitgebreid overleg gevoerd met telers van biologische groenten over de vraag hoe de toenemende druk van grondgebonden bodemziekten het hoofd geboden kunnen worden. Tijdens deze gesprekken kwam duidelijk naar voren dat de huidige specialisatie in de vruchtgroenteteelt en het jaarrond telen van onderling vergelijkbare gewassen risicovol is vanwege de voortdurende dreiging van opbrenstvermindering of productieverlies ten gevolge van bodemziekten en -plagen. Naast het zoeken van allerlei bodemverbeteraars of het ontwikkelen van minder vatbare onderstammen of gewassen, werden ook andere vormen van wisselteelt als mogelijke opties aangedragen. Hierbij is besproken welke bedrijfs- of teeltsystemen zicht lenen voor een wisselteeltsysteem en welke vormen in aanmerking komen voor verdere uitwerking. In deze studie worden de gebruiksmogelijkheden en perspectieven van tien soorten wisselsystemen op een rij gezet. Ze zijn beoordeeld op de factoren: effecten op de bodemweerbaarheid, technische en economische inpasbaarheid in het huidige bedrijfssysteem en de noodzaak tot samenwerken.
- Published
- 2007
37. biologische kringloopkas : toekomstbeelden voor 2020
- Author
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Blom, G., Os, E. Van, Lans, C. Van Der, Ruijs, M., Janmaat, L., Koopmans, C., Blom, G., Os, E. Van, Lans, C. Van Der, Ruijs, M., Janmaat, L., and Koopmans, C.
- Abstract
Concepten voor de Biologische Productiekas en de Biologische Stadskas in 2020 in het project Biologische Kringloopkas
- Published
- 2007
38. Valt er geld te verdienen met geconditioneerd telen? : Informatiemarkt Tuinbouw – LTO Groeiservice, 8 november 2007
- Author
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Ruijs, M. and Ruijs, M.
- Abstract
Presentatie door Marc Ruijs (LEI / Wageningen UR Glastuinbouw), gehouden op 8 november 2007 tijdens de Informatiemarkt Tuinbouw – LTO Groeiservice. Ruijs belichtte diverse aspecten van geconditioneerd telen; de achtergronden, systemen, verschillen in uitvoering, investeringen, energie en productie, terugverdientijd, huidige inzichten, voorlopige conclusies en de kansen voor geconditioneerd telen
- Published
- 2007
39. Ruimte voor Greenports : een kwalitatieve studie naar de maatschappelijke effecten van infrastructurele en milieutechnische maatregelen in de Greenports
- Author
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Hietbrink, O., Ruijs, M., Vlist, A. van der, Staalduinen, J. van, Hietbrink, O., Ruijs, M., Vlist, A. van der, and Staalduinen, J. van
- Published
- 2006
40. Research guidance : de rode draad bij (systeem)innovaties 'Methodische verdieping in transitie' 6 oktober 2005
- Author
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Ravensbergen, P., Wolfert, S., Smit, B., Geerling-Eiff, F., Poel, M., Prins, H., Ruijs, M., Verstegen, J., Ravensbergen, P., Wolfert, S., Smit, B., Geerling-Eiff, F., Poel, M., Prins, H., Ruijs, M., and Verstegen, J.
- Abstract
Tijdens de Wageningen UR studiedag 'Methodische verdieping in transitie', op 6 oktober 2005, hield Peter Ravensbergen (LEI) een presentatie over 'research guidance' : de rode draad bij (systeem)innovaties, in het kader van 'hoe verder met het methodisch onderzoek binnen Wageningen UR rond transitie'
- Published
- 2005
41. ENVIRONMENTAL IMPACT ASSESSMENT OF DUTCH TOMATO CROP PRODUCTION IN A VENLO GLASSHOUSE
- Author
-
Antón, A., primary, Torrellas, M., additional, Montero, J.I., additional, Ruijs, M., additional, Vermeulen, P., additional, and Stanghellini, C., additional
- Published
- 2012
- Full Text
- View/download PDF
42. Emissievrije kas
- Author
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Ruijs, M. and Ruijs, M.
- Abstract
Wat houdt het onderzoeksproject ´emissievrije kas´ in? Daarover gaat deze factsheet. Emissievrije kas is onderdeel van de onderzoeksprogramma’s Systeeminnovaties plantaardige productiesystemen van Wageningen UR.
- Published
- 2004
43. Innovatie voor intensivering
- Author
-
Poot, E., Kipp, J., Maas, B. Van Der, Roestel, A. Van, Weel, P. Van, Welles, G., Wildschut, J., Bethe, F., Ruijs, M., Dubbeldam, R., Poot, E., Kipp, J., Maas, B. Van Der, Roestel, A. Van, Weel, P. Van, Welles, G., Wildschut, J., Bethe, F., Ruijs, M., and Dubbeldam, R.
- Abstract
In het kader van een onderzoek naar systeeminnovatie in bedekte teelten (biologisch en geïntegreerd) is dit rapport verschenen. Het doet verslag van de zoektocht naar nieuwe ideeën voor de glastuinbouw en het vinden van een wetenschappelijke methode om die ideeën in samenwerking met een hele sector te formuleren.
- Published
- 2004
44. Distress in partners of individuals diagnosed with or at high risk of developing tumors due to rare hereditary cancer syndromes
- Author
-
Lammens, C. R. M., primary, Bleiker, E. M. A., additional, Verhoef, S., additional, Ausems, M. G. E. M., additional, Majoor‐Krakauer, D., additional, Sijmons, R. H., additional, Hes, F. J., additional, Gómez‐García, E. B., additional, Van Os, T. A. M., additional, Spruijt, L., additional, van der Luijt, R. B., additional, van den Ouweland, A. M. W., additional, Ruijs, M. W. G., additional, Gundy, C., additional, Nagtegaal, T., additional, and Aaronson, N. K., additional
- Published
- 2011
- Full Text
- View/download PDF
45. TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes
- Author
-
Ruijs, M. W. G., primary, Verhoef, S., additional, Rookus, M. A., additional, Pruntel, R., additional, van der Hout, A. H., additional, Hogervorst, F. B. L., additional, Kluijt, I., additional, Sijmons, R. H., additional, Aalfs, C. M., additional, Wagner, A., additional, Ausems, M. G. E. M., additional, Hoogerbrugge, N., additional, van Asperen, C. J., additional, Gomez Garcia, E. B., additional, Meijers-Heijboer, H., additional, ten Kate, L. P., additional, Menko, F. H., additional, and van 't Veer, L. J., additional
- Published
- 2010
- Full Text
- View/download PDF
46. ASSESSMENT OF POST-TRAUMATIC AMNESIA IN YOUNG CHILDREN
- Author
-
Ruijs, M. B. M., primary, Keyser, A., additional, and Gabreëls, F. J. M., additional
- Published
- 2008
- Full Text
- View/download PDF
47. Economische en bedrijfskundige aspecten van milieuvriendelijkere bedrijfssystemen in de glastuinbouw. Project B: Simulatie van milieuvriendelijkere bedrijfssystemen in de glastuinbouw. Gewasgroep: eenmalig oogstbare snijbloemen
- Author
-
Ruijs, M.
- Subjects
Proefstation voor de Tuinbouw onder Glas ,Life Science ,Glasshouse Crops Research Station - Published
- 1990
48. Economische en bedrijfskundige aspecten van milieuvriendelijkere bedrijfssystemen in de glastuinbouw : project B: Simulatie van milieuvriendelijkere bedrijfssystemen in de glastuinbouw : gewasgroep: 'eenmalig oogstbare groenten (sla en radijs)'
- Author
-
Ruijs, M., van Os, E., and van der Eijk, C.J.
- Subjects
teelt onder bescherming ,Proefstation voor de Tuinbouw onder Glas ,protected cultivation ,netherlands ,cropping systems ,farm management ,vegetable growing ,nederland ,greenhouses ,kassen ,agrarische economie ,agricultural economics ,Glasshouse Crops Research Station ,agrarische bedrijfsvoering ,groenteteelt ,teeltsystemen - Published
- 1990
49. Assessment of post-traumatic amnesia in young children.
- Author
-
Ruijs, M. B. M., Keyser, A., Gabreëls, F. J. M., Ruijs, M B, and Gabreëls, F J
- Published
- 1992
- Full Text
- View/download PDF
50. Kasklimaat bepalend voor optimaal gasverbruik
- Author
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Ruijs, M., Goossens, H., Ruijs, M., and Goossens, H.
- Abstract
Een groep paprikatuinders uit het Westland en De Kring neemt deel aan het project dat de NTS eind vorig jaar is gestart. De centrale vraag is hoe meer energie kan worden gespaard in de bestaande bedrijfssituatie. Uit de tussenresultaten blijkt dat het binnenklimaat de verschillen in gasverbruik tussen bedrijven meer beinvloedt dan de bedrijfsopzet of het buitenklimaat
- Published
- 1996
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