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The wettability of coal is of great significance to coal seam water injection and dust prevention. In order to study the influence mechanism of surfactant on the wettability of coal dust surface, the coal dust deposition experiment was carried out with the anthracite in Guizhou mining areas as the research object, and the surfactant solution with the best wetting effect was selected. With the help of infrared spectroscopy experiment and Zeta potential measurement experiment, the change law of coal surface wettability under the action of surfactants was explored. The results show that: the four surfactants used in the experiment can greatly improve the wettability of coal dust. Among them, 1% APG has the best wetting effect on coal dust; after modification, the hydrophilic groups and hydrophobic groups of the experimental coal samples increased, but the increase of hydrophilic groups was significantly greater than that of hydrophobic groups. It shows that the effect of surfactant modification on hydrophilic groups is more significant, which is beneficial to improve the hydrophilicity of coal dust surface; after modification, the surface negative charge of the experimental coal sample increased by about 7.68 times, causing the shear surface in the electric double layer to slide to the liquid surface, and strengthening the dipole force between the oxygen-containing functional groups and the water molecules, resulting in the thickening of the hydration layer and the improvement of the surface wettability of the coal sample.

At present, sulfur dioxide (SO2) treatment is the most widely used storage and fresh-keeping method of grape fruits, which has many advantages such as good bacteriostatic effect, convenient use and low cost. However, excessive SO2 in the environment will lead to serious damage to grape fruits, especially the phenomenon of fruit shattering and bleaching, resulting in greater losses. In view of the problem of grape berry abscission caused by excessive SO2 in the environment, this paper reviewes the relevant research progress at home and abroad, and discussed the mechanism of grape berry abscission from five aspects: Affecting stomata opening, damaging tissue structure, changing cell wall degrading enzyme activity, affecting hormone content and reactive oxygen species level. Finally, the research and application prospects of SO2 in grape fruit preservation are prospected in order to provide a theoretical basis for the accurate application of SO2 in grape preservation and the realization of loss reduction and efficiency improvement.

The concept of urban resilience focuses on understanding the process and mechanisms of disaster occurrence, providing innovative approaches to address stormwater flooding. However, existing studies primarily concentrate on enhancing overall system resilience, with limited research examining the temporal progression from stormwater disturbance to flood generation. To fill this gap, this study categorizes the development process of stormwater flooding into three periods: disturbance resistance (DR), adjustment and adaptation (AA), and rapid recovery (RR). Using the SWMM (Storm Water Management Model) software, 27 representative parcels in the Beijing-Tianjin-Hebei region of China were simulated. By sequentially considering single-indicator control variables, resilience indicators that significantly impact the three periods were identified through the construction of a stormwater flooding resilience indicator library. Subsequently, resilience models for each disaster phase were constructed using the BP (Back Propagation) neural network, and genetic algorithms were employed to optimize the models and determine the optimal values of resilience indicators for each period. Finally, the research findings were summarized into a resilience design method for the built environment to address stormwater flooding, accompanied by a guide for improving stormwater flooding resilience.The study reveals the following key findings: (1) the influence of physical and spatial elements in the built environment on stormwater flooding formation varies across different stages of the disaster process; (2) distinct resilience indicators operate at different times and in different ways throughout the entire stormwater flooding resilience process; (3) enhancing stormwater flooding resilience in the built environment does not necessarily require setting specific threshold values for each influencing indicator; instead, an optimal single value emerges when multiple indicators interact. Moreover, when multiple indicators interact, an optimal combination module with the best value for a single indicator exists. This study investigates the complete cycle from storm disturbance to flood disaster formation, offering both solutions for cities to mitigate storm flood disasters and advancing theoretical research on urban storm flood resilience while fostering interdisciplinary integration.

Drug resistance is one of the major causes of cancer treatment failures. In recent years, to combat the issue of drug resistance, a large volume of strategies has been established along the development of biomedical nanomaterials. Compared with traditional nanocarrier-based drug delivery strategies, in situ supramolecular self-assembly has emerged as a promising strategy to overcome drug resistance. This review first introduced the concept of in situ supramolecular self-assembly. The second part illustrated the mechanisms of constructing in situ supramolecular self-assembly as a multi-step process. The third part elucidated the role of in situ supramolecular self-assembly to reverse drug resistance, which included three categories: active self-assembly materials, drug-carrier self-assembly materials and drug-coupled self-assembly materials. At last, we summarized the current development of in situ supramolecular self-assembly for the reversal of drug resistance and the remaining concerns to be addressed.

Abstract Histone lysine demethylases (KDMs) have been reported in various malignances, which affect transcriptional regulation of tumor suppressor or oncogenes. However, the relationship between KDMs and formation of tumor microenvironment (TME) in gastric cancer (GC) remain unclear and need to be comprehensively analyzed. In the present study, 24 KDMs were obtained and consensus molecular subtyping was performed using the "NMF" method to stratify TCGA-STAD into three clusters. The ssGSEA and CIBERSORT algorithms were employed to assess the relative infiltration levels of various cell types in the TME. The KDM_score was devised to predict patient survival outcomes and responses to both immunotherapy and chemotherapy. Three KDM genes-related molecular subtypes were Figured out in GC with distinctive clinicopathological and prognostic features. Based on the robust KDM genes-related risk_score and nomogram, established in our work, GC patients’ clinical outcome can be well predicted. Furthermore, low KDM genes-related risk_score exhibited the more effective response to immunotherapy and chemotherapy. This study characterized three KDM genes-related TME pattern with unique immune infiltration and prognosis by comprehensively analyses of transcriptomic profiling. Risk_score was also built to help clinicians decide personalized anticancer treatment for GC patients, including in prediction of immunotherapy and chemotherapy response for patients.

β-Ga2O3 is a promising material for the development of next-generation power electronic and optoelectronic devices due to its exceptional properties, including ultrawide bandgap and thermodynamic stability. Strain engineering has emerged as a powerful method to modulate the physical properties of materials and has been widely employed in semiconductor devices to enhance their performance and functionality. Our study focuses on the effects of strain engineering on the electronic properties of β-Ga2O3. Using density functional theory, we calculated the band structures and electron effective masses of β-Ga2O3 under different strain states. Our investigation revealed that strain manipulation can induce an indirect-direct bandgap transition. Strain can also lead to changes in effective masses and anisotropy of electron mobility. Our calculations provide important insights into the potential of strain engineering as a powerful tool for modulating the electronic properties of β-Ga2O3, with important implications for practical device applications.

In this study, octadecylamine/graphite foam composite phase change materials (ODA/GF CPCMs) were prepared by vacuum impregnation; octadecylamine (ODA) was used as the phase change materials (PCMs), and graphite foam (GF) was used as the support material. Polyurethane (PU) foam obtained after hydrolysis in 40 wt% NaOH solution at 80 °C for 30 min was the template for the GF; therefore, the prepared GF has many interpenetrating pore structures, providing many adsorption sites for PCMs. For the ODA/GF-3 CPCMs with 15 wt% graphite addition, the loading of ODA is as high as 92.3%, the thermal stability is excellent, the melting temperature is 52.1 °C, and the latent heat of fusion is 218. 1 J/g, which is 1.1 times that of pure ODA. The thermal conductivity of ODA/GF-3 CPCMs is 0.725 W/m•K, which is 2.2 times that of pure ODA. These results indicate that ODA/GF CPCMs have good thermal properties, and their competitiveness in the field of energy storage is greatly improved due to their excellent performance.

Summary: Flexible perovskite solar cells (PSCs) are highly promising photovoltaic technologies due to the prospect of integration with wearable devices. However, conventional encapsulation strategies for flexible devices often cause secondary damage to the perovskite crystals, which affects device performance. Here, we present self-encapsulated flexible PSCs realized by lamination technology. The conversion of perovskite crystals is achieved by the diffusion of lead iodide and ammonium halide under the effect of temperature and pressure. In addition, the hydrogen bonding of the introduced polyacrylamide enhances the connections of the integral device while improving the crystal quality. The self-encapsulated flexible PSCs achieve an outstanding photovoltaic conversion efficiency of 22.33%, and comprehensive stability tests are conducted based on wearable device application scenarios to verify the feasibility. Finally, 25 cm2 wearable perovskite modules are successfully applied into the neuro-assisted wearable devices.

Tumor cell migration induced by arsenite (iAsIII) is closely associated with cancer progression. However, transcriptomic and metabolic traits of migrative human cells exposed to iAsIII remain to be well characterized. Here, the combination of transcriptomics and metabolomics approaches were employed to construct interactive networks of functional genes and metabolites in human colorectal cancer (DLD-1) cells exposed to iAsIII. The number of DLD-1 cells passing through the Transwell membrane was at least 6 times greater in the iAsIII-treated groups than in controls. Following iAsIII treatment, the expression of ZEB1 and SLUG protein was significantly upregulated while the expression of CRB2 was downregulated (p

Introduction: In the development of atherosclerosis, the remodeling of blood vessels is a key process involving plaque formation and rupture. So far, most reports mainly believe that macrophages, smooth muscle cells, and endothelial cells located at the intima and media of artery play the key role in this process. Few studies had focused on whether fibroblasts located at adventitia are involved in regulating disease process.Methods and results: In this study, we conducted in-depth analysis of single-cell RNA-seq data of the total of 18 samples from healthy and atherosclerotic arteries. This study combines several analysis methods including transcription regulator network, cell-cell communication network, pseudotime trajectory, gene set enrichment analysis, and differential expression analysis. We found that SERPINF1 is highly expressed in fibroblasts and is involved in the regulation of various signaling pathways.Conclusion: Our research reveals a potential mechanism of atherosclerosis, SERPINF1 regulates the formation and rupture of plaques through the Jak-STAT signaling pathway, which may provide new insights into the pathological study of disease. Moreover, we suggest that SRGN and IGKC as potential biomarkers for unstable arterial plaques.

Abstract Extensive investigation of the passivating agents has been performed to suppress the perovskite defects. However, very few attentions have been paid to rationally design the passivating agents for the balance of the carrier confinement and transfer in quasi-2D perovskites, which is essential to achieve high-performance perovskite LEDs (PeLEDs). In this work, tributylphosphine oxide (TBPO) with moderate carbon chain length is demonstrated as a decent passivator for the quasi-2D perovskites by strengthening the carrier confinement for massive radiative recombination within the perovskites, and more importantly providing efficient carrier transfer in the quasi-2D perovskites. Benefiting from these interesting optoelectronic properties of TBPO-incorporated perovskites, we achieve high-efficient blue PeLEDs with an external quantum efficiency up to 11.5% and operational stability as long as 41.1 min without any shift of the electroluminescence spectra. Consequently, this work contributes an effective approach to promote the carrier confinement and transfer for high-performance and stable blue PeLEDs.

Abstract Background The association between tumour microenvironment (TME) in colorectal cancer (CRC) and cell death patterns requires further exploration. Cuproptosis may provide new insight into analyzing CRC's TME. Methods We used cuproptosis‐related genes (CRGs) to stratify the meta‐Gene‐Expression Omnibus cohort by the “non‐negative matrix factorization” consistency matrix algorithm. To clarify the relative abundance of different cells in TME, CIBERSORT and single‐sample gene set enrichment methods were performed. Then, CRGs’ transcription in different cell types and the spatial position of CRGs’ enrichment were demonstrated through single‐cell spatial transcriptomics (STs) analysis. Prediction of clinical outcomes and response rate of immunotherapy was also conducted by constructing CRG_score. Results Three cuproptosis‐related TME phenotypes were figured out in CRC with distinctive clinicopathological and prognostic features. Three phenotypes were identical to immune‐inflamed, immune‐desert and immune‐excluded profiles, respectively. Interestingly, cuproptosis‐related cluster 3 (CPRC3) phenotype‐related gene_score was predominantly upregulated in the fibroblast region, consisting of stromal cells. This result was in line with CPRC3's immune‐excluded profile. Based on the robust cuproptosis‐related risk_score and nomogram, CRC patients’ clinical outcome and response to PD1/PD‐L1 immunotherapy can be well predicted. Conclusions This study characterized three cuproptosis‐related TME patterns with unique immune infiltration and prognosis in both bulk and single‐cell ST profiling. Risk_score was also built to help clinicians decide on personalized anticancer treatment and immunotherapy applications for CRC patients.

Cardiac remodelling is widely accepted as a common characteristic for many heart diseases, especially in heart failure (HF). Ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are associated with cardiac remodelling. Both mRNA and microRNA are potential diagnostic markers and therapeutic targets of cardiac remodelling in HF. However, the mechanisms of microRNA-mRNA joint regulation in HF are still unclear. In this study, 3 gene expression profiles from patients with and without HF were analysed to harvest shared differentially expressed genes (microRNA and mRNA) with significant major biological function. Moreover, key genes highly related to ICM and DCM-induced HF were screened out through a Weighted Genes Co-Expression Network Analysis (WGCNA). Based on microRNA-mRNA analysis, several microRNAs and target genes were identified. Combined with pathway analysis, we found that miR-542-3p and its target gene CILP were likely involved in the regulation of TGF-β signalling pathway in ICM induced HF. Collectively, the microRNA–mRNA interaction network analysis revealed that miR-542-3p-CILP as mediator of TGF-β signalling pathway might be a new mechanism to mediate ICM induced HF. This study provides certain novel targets for diagnosis and therapeutic treatment of ICM- and DCM-induced HF.

Abstract Background The elevation of plasma D‐dimer levels may predict a higher risk of thrombosis and play a role in the pathological process of patients after spontaneous intracerebral hemorrhage (ICH). However, its function in predicting the prognosis of ICH has not been verified on large cases. Patients and Methods Retrospective cohort study of 1,332 consecutive patients with spontaneous ICH at an academic medical center was conducted. Functional outcome at three months after ICH was dichotomized using the modified Rankin Scale (0–2 versus 3–6). D‐dimer level in blood was analyzed within 1 hr of admission. An ICH outcome score combining D‐dimer level for evaluating poor functional outcome and mortality was tested. Results The proportion of patients with poor functional outcome and mortality at three months was significantly higher in patients with elevated D‐dimer level (p

In this work, oil-in-water emulsions stabilised by milk protein concentrate (MPC70) were investigated. The MPC70 concentration was kept constant at 5% (close to the protein content found in skim milk) and the oil volume fraction was varied from 20 to 65%. Sonication was performed at 20 kHz and at a constant power of 14.4 W for a total emulsion volume of 10 mL. Under certain oil concentration (≥35%) and sonication times (≥3s) the emulsion aggregated and formed high-viscosity pseudo plastic materials. However, the viscosity behaviour of the emulsion made with 35% oil reverted to that of a liquid if sonicated for longer times (≥15 s). Confocal laser scanning microscopy showed clearly that the oil droplets are aggregated under the sonication conditions and oil concentrations indicated above. An attempt to explain this behaviour through a simple model based on the bridging of oil droplets by the MPC70 particles and, taking into account the oil droplet and MPC70 particle sizes as well as the oil volume fraction, was made. The model fails to describe in details the aggregation behaviour of these emulsions, likely due to the inhomogeneous protein layer, where both free caseins and casein micelles are adsorbed, and to the packing of the oil droplets at concentrations ≤55%. Nonetheless, this work demonstrates the potential of ultrasound processing for the formation of dairy emulsions with tailored textures.

Car-hailing service has increasingly become popular and fundamentally changed the way people travel in the era of sharing economy. Although such service brings convenience to people's lives, it also causes safety and property concerns. Many studies have been conducted to access the efficiency and effectiveness of car-hailing, but little has been done on its safety monitoring. However, with the rapid development of information technologies such as Internet of Things (IoT), Geographical Information Science (GIS) and automatic monitoring, a more advantageous approach than the current simple drivers screening and testing is feasible. A new model including five indexes i.e. region dangerous index, offset distance of the origin-destination, real-time speed under traffic conditions, vehicle travel time and passenger information, is therefore proposed in this paper based on big data mining of the historical vehicle GPS trajectory data. Experiments were conducted to validate the model in the Gangzha District of Nantong City, China. Several other types of data were used in the experiments, e.g. points of interest (POI), road network data and urban image. The results showed that the proposed model effectively monitored the vehicle when it was driving in a “potentially dangerous area”. In addition, the model could accurately identify the driver's abnormal driving behaviors, such as bypass and abnormal stop. The prediction accuracy of the experiments was 92.06%, among which the discrimination accuracy of the abnormal stop was 100% and that of the detour was 90.57%. All these validate the applicability of the model for future management systems for car-hailing services.

In this study, pure zinc stannate (ZnSnO3) and bismuth (Bi)-doped ZnSnO3 composites (Bi-ZnSnO3) were synthesized via the in situ precipitation method, and their microstructures, morphologies, chemical components, sizes, and specific surface areas were characterized, followed by testing their gas sensing properties. The results revealed that Bi-ZnSnO3 showed superior gas sensing properties to n-butanol gas, with an optimal operating temperature of 300 °C, which was 50 °C lower than that of pure ZnSnO3. At this temperature, moreover, the sensitivity of Bi-ZnSnO3 to n-butanol gas at the concentration of 100 ppm reached as high as 1450.65, which was 35.57 times that (41.01) of ammonia gas, 2.93 times that (495.09) of acetone gas, 6.02 times that (241.05) of methanol gas, 2.54 times that (571.48) of formaldehyde gas, and 2.98 times that (486.58) of ethanol gas. Bi-ZnSnO3 had a highly repeatable performance. The total proportion of oxygen vacancies and chemi-adsorbed oxygen in Bi-ZnSnO3 (4 wt%) was 27.72% to 32.68% higher than that of pure ZnSnO3. Therefore, Bi-ZnSnO3 has considerable potential in detecting n-butanol gas by virtue of its excellent gas-sensing properties.

Probiotic bacteria have been associated with various health benefits and included in overwhelming number of foods. Today, probiotic supplements are consumed with increasing regularity and record a rapidly growing economic value. With billions of heterogeneous populations of probiotics per serving, probiotic supplements contain the largest quantity of probiotics across all functional foods. They often carry antibiotic-resistant determinants that can be transferred to and accumulate in resident bacteria of the gastrointestinal tract and risk their acquisitions by opportunistic pathogens. While the health benefits of probiotics have been widely publicized, this health risk, however, is underrepresented in both scientific studies and public awareness. On the other hand, the human gut presents conditions that are unfavorable for bacteria, including probiotics. It remains uncertain if probiotics from supplements can tolerate acids and bile salts that may undermine their effectiveness in conferring health benefits. Here, we put into perspective the perceived health benefits and the long-term safety of consuming probiotic supplements, specifically bringing intolerance to acids and bile salts, and the long-standing issue of antibiotic-resistant gene transfer into sharp focus. We report that probiotics from supplements examined in this study have poor tolerance to acids and bile salts while also displaying resistance to multiple antibiotics. They could also adapt and gain resistance to streptomycin in vitro. In an environment where consuming supplements is considered a norm, our results and that of others will put in perspective the persisting concerns surrounding probiotic supplements so that the current hype does not overpower the hope.

Probiotic bacteria are known to harbor intrinsic and mobile genetic elements that confer resistance to a wide variety of antibiotics. Their high amounts in dietary supplements can establish a reservoir of antibiotic resistant genes in the human gut. These resistant genes can be transferred to pathogens that share the same intestinal habitat thus resulting in serious clinical ramifications. While antibiotic resistance of probiotic bacteria from food, human and animal sources have been well-documented, the resistant profiles of probiotics from dietary supplements have only been recently studied. These products are consumed with increasing regularity due to their health claims that include the improvement of intestinal health and immune response as well as prevention of acute and antibiotic-associated diarrhea and cancer; but, a comprehensive risk assessment on the spread of resistant genes to human health is lacking. Here, we highlight recent reports of antibiotic resistance of probiotic bacteria isolated from dietary supplements, and propose complementary strategies that can shed light on the risks of consuming such products in the context of a global widespread of antibiotic resistance. In concomitant with a broader screening of antibiotic resistance in probiotic supplements is the use of computational simulations, live imaging and functional genomics to harvest knowledge on the evolutionary behavior, adaptations and dynamics of probiotics studied in conditions that best represent the human gut including in the presence of antibiotics. The underlying goal is to enable the health benefits of probiotics to be exploited in a responsible manner and with minimal risk to human health.