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2. Long-term lifestyle change and risk of mortality and type 2 diabetes in patients with cardiovascular disease

Author

Interne Geneeskunde Vasculaire, Circulatory Health, Team Medisch, MS Interne Geneeskunde, Neurologen, Brain, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Unit Opleiding Aios, Bonekamp, Nadia E, Visseren, Frank L J, Cramer, Maarten J, Dorresteijn, Jannick A N, van der Meer, Manon G, Ruigrok, Y M, van Sloten, Thomas T, Teraa, Martin, Geleijnse, Johanna M, Koopal, Charlotte, Interne Geneeskunde Vasculaire, Circulatory Health, Team Medisch, MS Interne Geneeskunde, Neurologen, Brain, Zorgeenheid Vaatchirurgie Medisch, Regenerative Medicine and Stem Cells, Unit Opleiding Aios, Bonekamp, Nadia E, Visseren, Frank L J, Cramer, Maarten J, Dorresteijn, Jannick A N, van der Meer, Manon G, Ruigrok, Y M, van Sloten, Thomas T, Teraa, Martin, Geleijnse, Johanna M, and Koopal, Charlotte

Published
2024

3. Anatomical differences of intracranial arteries according to sex: a systematic review and meta-analysis

Author

Projectafdeling CVZ, Beeldverwerking ISI, Cancer, Researchgr. Hart-brein as., Brain, Circulatory Health, Neurologen, Ophelders, M. E.H., van Eldik, M. J.A., Vos, I. N., Beentjes, Y. S., Velthuis, B. K., Ruigrok, Y. M., Projectafdeling CVZ, Beeldverwerking ISI, Cancer, Researchgr. Hart-brein as., Brain, Circulatory Health, Neurologen, Ophelders, M. E.H., van Eldik, M. J.A., Vos, I. N., Beentjes, Y. S., Velthuis, B. K., and Ruigrok, Y. M.

Published
2024

4. Sex differences in modifiable risk factors for stroke incidence and recurrence: the UCC-SMART study.

Author

Rissanen, Ina, Basten, Maartje, Exalto, Lieza G., Peters, Sanne A. E., Visseren, Frank L. J., Geerlings, Mirjam I., For the UCC-SMART-Study Group, Cramer, M. J., van der Meer, M. G., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot-Vonk, M. H., de Jong, P. A., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., and Verhaar, M. C.

Subjects
SEX factors in disease, DISEASE risk factors, DYSLIPIDEMIA, HEMORRHAGIC stroke, PROPORTIONAL hazards models, STROKE
Abstract

Background and purpose: Risk factors for stroke differ between women and men in general populations. However, little is known about sex differences in secondary prevention. We investigated if sex interacted with modifiable risk factors for stroke in a large arterial disease cohort. Methods: Within the prospective UCC-SMART study, 13,898 patients (35% women) with atherosclerotic disease or high-risk factor profile were followed up to 23 years for stroke incidence or recurrence. Hypertension, smoking, diabetes, overweight, dyslipidemia, high alcohol use, and physical inactivity were studied as risk factors. Association between these factors and ischemic and hemorrhagic stroke incidence or recurrence was studied in women and men using Cox proportional hazard models and Poisson regression models. Women-to-men relative hazard ratios (RHR) and rate differences (RD) were estimated for each risk factor. Left-truncated age was used as timescale. Results: The age-adjusted stroke incidence rate was lower in women than men (3.9 vs 4.4 per 1000 person-years), as was the age-adjusted stroke recurrence rate (10.0 vs 11.7). Hypertension and smoking were associated with stroke risk in both sexes. HDL cholesterol was associated with lower stroke incidence in women but not in men (RHR 0.49; CI 0.27–0.88; and RD 1.39; CI − 1.31 to 4.10). Overweight was associated with a lower stroke recurrence in women but not in men (RHR 0.42; CI 0.23–0.80; and RD 9.05; CI 2.78–15.32). Conclusions: In high-risk population, sex modifies the association of HDL cholesterol on stroke incidence, and the association of overweight on stroke recurrence. Our findings highlight the importance of sex-specific secondary prevention. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Author

Bakker, M, Kanning, J, Abraham, G, Martinsen, A, Winsvold, B, Zwart, J, Bourcier, R, Sawada, T, Koido, M, Kamatani, Y, Morel, S, Amouyel, P, Debette, S, Bijlenga, P, Berrandou, T, Ganesh, S, Bouatia-Naji, N, Jones, G, Bown, M, Rinkel, G, Veldink, J, Ruigrok, Y, Hege Aamodt, A, Heidi Skogholt, A, Brumpton, B, Willer, C, Sandset, E, Kristoffersen, E, Ellekjær, H, Heuch, I, Nielsen, J, Hagen, K, Hveem, K, Fritsche, L, Thomas, L, Pedersen, L, Gabrielsen, M, Holmen, O, Børte, S, Zhou, W, Abboud, S, Pandolfo, M, Thijs, V, Leys, D, Bodenant, M, Louillet, F, Touzé, E, Mas, J, Samson, Y, Leder, S, Léger, A, Deltour, S, Crozier, S, Méresse, I, Canaple, S, Godefroy, O, Giroud, M, Béjot, Y, Decavel, P, Medeiros, E, Montiel, P, Moulin, T, Vuillier, F, Dallongeville, J, Metso, A, Metso, T, Tatlisumak, T, Grond-Ginsbach, C, Lichy, C, Kloss, M, Werner, I, Arnold, M, Dos Santos, M, Grau, A, Dichgans, M, Thomas-Feles, C, Weber, R, Brandt, T, Pezzini, A, De Giuli, V, Caria, F, Poli, L, Padovani, A, Bersano, A, Lanfranconi, S, Beretta, S, Ferrarese, C, Giacolone, G, Paolucci, S, Lyrer, P, Engelter, S, Fluri, F, Hatz, F, Gisler, D, Bonati, L, Gensicke, H, Amort, M, Markus, H, Majersik, J, Worrall, B, Bakker M. K., Kanning J. P., Abraham G., Martinsen A. E., Winsvold B. S., Zwart J. A., Bourcier R., Sawada T., Koido M., Kamatani Y., Morel S., Amouyel P., Debette S., Bijlenga P., Berrandou T., Ganesh S. K., Bouatia-Naji N., Jones G., Bown M., Rinkel G. J. E., Veldink J. H., Ruigrok Y. M., Hege Aamodt A., Heidi Skogholt A., Brumpton B. M., Willer C. J., Sandset E. C., Kristoffersen E. S., Ellekjær H., Heuch I., Nielsen J. B., Hagen K., Hveem K., Fritsche L. G., Thomas L. F., Pedersen L. M., Gabrielsen M. E., Holmen O. L., Børte S., Zhou W., Abboud S., Pandolfo M., Thijs V., Leys D., Bodenant M., Louillet F., Touzé E., Mas J. L., Samson Y., Leder S., Léger A., Deltour S., Crozier S., Méresse I., Canaple S., Godefroy O., Giroud M., Béjot Y., Decavel P., Medeiros E., Montiel P., Moulin T., Vuillier F., Dallongeville J., Metso A. J., Metso T., Tatlisumak T., Grond-Ginsbach C., Lichy C., Kloss M., Werner I., Arnold M. L., Dos Santos M., Grau A., Dichgans M., Thomas-Feles C., Weber R., Brandt T., Pezzini A., De Giuli V., Caria F., Poli L., Padovani A., Bersano A., Lanfranconi S., Beretta S., Ferrarese C., Giacolone G., Paolucci S., Lyrer P., Engelter S., Fluri F., Hatz F., Gisler D., Bonati L., Gensicke H., Amort M., Markus H., Majersik J., Worrall B., Bakker, M, Kanning, J, Abraham, G, Martinsen, A, Winsvold, B, Zwart, J, Bourcier, R, Sawada, T, Koido, M, Kamatani, Y, Morel, S, Amouyel, P, Debette, S, Bijlenga, P, Berrandou, T, Ganesh, S, Bouatia-Naji, N, Jones, G, Bown, M, Rinkel, G, Veldink, J, Ruigrok, Y, Hege Aamodt, A, Heidi Skogholt, A, Brumpton, B, Willer, C, Sandset, E, Kristoffersen, E, Ellekjær, H, Heuch, I, Nielsen, J, Hagen, K, Hveem, K, Fritsche, L, Thomas, L, Pedersen, L, Gabrielsen, M, Holmen, O, Børte, S, Zhou, W, Abboud, S, Pandolfo, M, Thijs, V, Leys, D, Bodenant, M, Louillet, F, Touzé, E, Mas, J, Samson, Y, Leder, S, Léger, A, Deltour, S, Crozier, S, Méresse, I, Canaple, S, Godefroy, O, Giroud, M, Béjot, Y, Decavel, P, Medeiros, E, Montiel, P, Moulin, T, Vuillier, F, Dallongeville, J, Metso, A, Metso, T, Tatlisumak, T, Grond-Ginsbach, C, Lichy, C, Kloss, M, Werner, I, Arnold, M, Dos Santos, M, Grau, A, Dichgans, M, Thomas-Feles, C, Weber, R, Brandt, T, Pezzini, A, De Giuli, V, Caria, F, Poli, L, Padovani, A, Bersano, A, Lanfranconi, S, Beretta, S, Ferrarese, C, Giacolone, G, Paolucci, S, Lyrer, P, Engelter, S, Fluri, F, Hatz, F, Gisler, D, Bonati, L, Gensicke, H, Amort, M, Markus, H, Majersik, J, Worrall, B, Bakker M. K., Kanning J. P., Abraham G., Martinsen A. E., Winsvold B. S., Zwart J. A., Bourcier R., Sawada T., Koido M., Kamatani Y., Morel S., Amouyel P., Debette S., Bijlenga P., Berrandou T., Ganesh S. K., Bouatia-Naji N., Jones G., Bown M., Rinkel G. J. E., Veldink J. H., Ruigrok Y. M., Hege Aamodt A., Heidi Skogholt A., Brumpton B. M., Willer C. J., Sandset E. C., Kristoffersen E. S., Ellekjær H., Heuch I., Nielsen J. B., Hagen K., Hveem K., Fritsche L. G., Thomas L. F., Pedersen L. M., Gabrielsen M. E., Holmen O. L., Børte S., Zhou W., Abboud S., Pandolfo M., Thijs V., Leys D., Bodenant M., Louillet F., Touzé E., Mas J. L., Samson Y., Leder S., Léger A., Deltour S., Crozier S., Méresse I., Canaple S., Godefroy O., Giroud M., Béjot Y., Decavel P., Medeiros E., Montiel P., Moulin T., Vuillier F., Dallongeville J., Metso A. J., Metso T., Tatlisumak T., Grond-Ginsbach C., Lichy C., Kloss M., Werner I., Arnold M. L., Dos Santos M., Grau A., Dichgans M., Thomas-Feles C., Weber R., Brandt T., Pezzini A., De Giuli V., Caria F., Poli L., Padovani A., Bersano A., Lanfranconi S., Beretta S., Ferrarese C., Giacolone G., Paolucci S., Lyrer P., Engelter S., Fluri F., Hatz F., Gisler D., Bonati L., Gensicke H., Amort M., Markus H., Majersik J., and Worrall B.

Published
2023

7. Relationship between diameter asymmetry and blood flow in the pre-communicating (A1) segment of the anterior cerebral arteries

Author

Onderzoek Beeld, Neurologen, Brain, Circulatory Health, Beeldverwerking ISI, Cancer, MS Radiologie, Regenerative Medicine and Stem Cells, Highfield Research Group, Researchgr. Hart-brein as., van Tuijl, R J, Ruigrok, Y M, Ophelders, MEH, Vos, I N, van der Schaaf, I C, Zwanenburg, JJM, Velthuis, B K, Onderzoek Beeld, Neurologen, Brain, Circulatory Health, Beeldverwerking ISI, Cancer, MS Radiologie, Regenerative Medicine and Stem Cells, Highfield Research Group, Researchgr. Hart-brein as., van Tuijl, R J, Ruigrok, Y M, Ophelders, MEH, Vos, I N, van der Schaaf, I C, Zwanenburg, JJM, and Velthuis, B K

Published
2023

8. Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease

Author

Hageman, Steven H. J., McKay, Ailsa J., Ueda, Peter, Gunn, Laura H., Jernberg, Tomas, Hagström, Emil, Bhatt, Deepak L., Steg, Ph. Gabriel, Läll, Kristi, Mägi, Reedik, Gynnild, Mari Nordbø, Ellekjær, Hanne, Saltvedt, Ingvild, Tuñón, José, Mahíllo, Ignacio, Aceña, Álvaro, Kaminski, Karol, Chlabicz, Malgorzata, Sawicka, Emilia, Tillman, Taavi, McEvoy, John W., di Angelantonio, Emanuele, Graham, Ian, de Bacquer, Dirk, Ray, Kausik K., Dorresteijn, Jannick A. N., Visseren, Frank L. J., Asselbergs, F. W., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L. J., Westerink, J., Halle, Martin, Timmis, Adam D., Lettino, Maddalena, Vardas, Panos E., McEvoy, John William, Graham, Ian M., and Academic Medical Center

Subjects
Cardiac & Cardiovascular Systems, PREDICTION, Myocardial Infarction, Residual risk, Risk Assessment, ARTERIAL-DISEASE, Recurrent risk, Risk Factors, Medicine and Health Sciences, Humans, Cardiac and Cardiovascular Systems, 1102 Cardiorespiratory Medicine and Haematology, METAANALYSIS, Science & Technology, Kardiologi, Secondary prevention, 1103 Clinical Sciences, ASSOCIATION, Atherosclerosis, Established ASCVD, COMPETING RISKS, PREVENTION, Risk prediction, Stroke, ASPIRIN, Cardiovascular System & Hematology, Cardiovascular Diseases, CLINICAL-PRACTICE, Personalized treatment, Cardiovascular System & Cardiology, Cardiology and Cardiovascular Medicine, OUTPATIENTS, Life Sciences & Biomedicine, Algorithms, Biomarkers, TASK-FORCE
Abstract

Aims The 10-year risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events in patients with established ASCVD can be estimated with the Secondary Manifestations of ARTerial disease (SMART) risk score, and may help refine clinical management. To broaden generalizability across regions, we updated the existing tool (SMART2 risk score) and recalibrated it with regional incidence rates and assessed its performance in external populations. Methods and results Individuals with coronary artery disease, cerebrovascular disease, peripheral artery disease, or abdominal aortic aneurysms were included from the Utrecht Cardiovascular Cohort-SMART cohort [n = 8355; 1706 ASCVD events during a median follow-up of 8.2 years (interquartile range 4.2-12.5)] to derive a 10-year risk prediction model for recurrent ASCVD events (non-fatal myocardial infarction, non-fatal stroke, or cardiovascular mortality) using a Fine and Gray competing risk-adjusted model. The model was recalibrated to four regions across Europe, and to Asia (excluding Japan), Japan, Australia, North America, and Latin America using contemporary cohort data from each target region. External validation used data from seven cohorts [Clinical Practice Research Datalink, SWEDEHEART, the international REduction of Atherothrombosis for Continued Health (REACH) Registry, Estonian Biobank, Spanish Biomarkers in Acute Coronary Syndrome and Biomarkers in Acute Myocardial Infarction (BACS/BAMI), the Norwegian COgnitive Impairment After STroke, and Bialystok PLUS/Polaspire] and included 369 044 individuals with established ASCVD of whom 62 807 experienced an ASCVD event. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] in BACS/BAMI to 0.772 (95% CI 0.659-0.886) in REACH Europe high-risk region. The clinical utility of the model was demonstrated across a range of clinically relevant treatment thresholds for intensified treatment options. Conclusion The SMART2 risk score provides an updated, validated tool for the prediction of recurrent ASCVD events in patients with established ASCVD across European and non-European populations. The use of this tool could allow for a more personalized approach to secondary prevention based upon quantitative rather than qualitative estimates of residual risk. Key objective To improve upon prediction of 10-year residual atherosclerotic cardiovascular disease (ASCVD) event risk in individuals with established ASCVD, by taking into account competing risks and geographical differences in ASCVD incidence. Key findings Derivation in 8355 individuals with established ASCVD from the Utrecht Cardiovascular Cohort-Secondary Manifestations of ARTerial disease (SMART) cohort. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] to 0.772 (95% CI 0.659-0.886). Clinical utility was demonstrated across a range of treatment thresholds relevant to therapy intensification. Take-home messages The SMART2 risk score can be used to estimate 10-year residual risk of fatal and non-fatal ASCVD in individuals with established ASCVD. Adapted to the CVD incidence in several global regions. Facilitates shared decision-making on Step 2 prevention goals as recommended by the 2021 ESC Guidelines on cardiovascular prevention.

Published
2022
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10. Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications

Author

MS Interne Geneeskunde, Circulatory Health, MS Radiologie, Arts-assistenten Radiologie, Beeldverwerking ISI, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Cancer, Researchgr. Systems Radiology, Infection & Immunity, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Interne Geneeskunde Vasculaire, Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, Van Der Veen, Pieternella H., Van Ginneken, Bram, Verlaan, Jorrit Jan, De Jong, P. A., Mohamed Hoesein, Firdaus A.A., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L.J., MS Interne Geneeskunde, Circulatory Health, MS Radiologie, Arts-assistenten Radiologie, Beeldverwerking ISI, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Cancer, Researchgr. Systems Radiology, Infection & Immunity, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Interne Geneeskunde Vasculaire, Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, Van Der Veen, Pieternella H., Van Ginneken, Bram, Verlaan, Jorrit Jan, De Jong, P. A., Mohamed Hoesein, Firdaus A.A., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., and Visseren, F. L.J.

Published
2022

11. Residual cardiovascular risk reduction guided by lifetime benefit estimation in patients with symptomatic atherosclerotic disease: Effectiveness and cost-effectiveness

Author

Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CCU Cardiologie, Team Medisch, HEE, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 7a, MS Geriatrie, Researchgr. Systems Radiology, Infection & Immunity, Cancer, MS Radiologie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Hageman, Steven H.J., Dorresteijn, Jannick A.N., Bots, Michiel L., Asselbergs, F. W., Westerink, Jan, Van Der Meulen, Miriam P., Mosterd, Arend, Visseren, F. L.J., Nathoe, H. M., De Borst, G. J., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CCU Cardiologie, Team Medisch, HEE, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 7a, MS Geriatrie, Researchgr. Systems Radiology, Infection & Immunity, Cancer, MS Radiologie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Hageman, Steven H.J., Dorresteijn, Jannick A.N., Bots, Michiel L., Asselbergs, F. W., Westerink, Jan, Van Der Meulen, Miriam P., Mosterd, Arend, Visseren, F. L.J., Nathoe, H. M., De Borst, G. J., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., and Verhaar, M. C.

Published
2022

12. Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications

Author

Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, van der Veen, Pieternella H., van Ginneken, Bram, Verlaan, Jorrit-Jan, de Jong, Pim A., Mohamed Hoesein, Firdaus A. A., Asselbergs, F. W., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L. J., General practice, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration, and APH - Aging & Later Life

Subjects
calcification, All institutes and research themes of the Radboud University Medical Center, Rheumatology, thoracic aortic calcification, atherosclerosis, diffuse idiopathic skeletal hyperostosis, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], bone formation
Abstract

Objectives. DISH has been associated with increased coronary artery calcifications and incident ischaemic stroke. The formation of bone along the spine may share pathways with calcium deposition in the aorta. We hypothesized that patients with DISH have increased vascular calcifications. Therefore we aimed to investigate the presence and extent of DISH in relation to thoracic aortic calcification (TAC) severity. Methods. This cross-sectional study included 4703 patients from the Second Manifestation of ARTerial disease cohort, consisting of patients with cardiovascular events or risk factors for cardiovascular disease. Chest radiographs were scored for DISH using the Resnick criteria. Different severities of TAC were scored arbitrarily from no TAC to mild, moderate or severe TAC. Using multivariate logistic regression, the associations between DISH and TAC were analysed with adjustments for age, sex, BMI, diabetes, smoking status, non-high-density lipoprotein cholesterol, cholesterol lowering drug usage, renal function and blood pressure. Results. A total of 442 patients (9.4%) had evidence of DISH and 1789 (38%) patients had TAC. The prevalence of DISH increased from 6.6% in the no TAC group to 10.8% in the mild, 14.3% in the moderate and 17.1% in the severe TAC group. After adjustments, DISH was significantly associated with the presence of TAC [odds ratio (OR) 1.46 [95% CI 1.17, 1.82)]. In multinomial analyses, DISH was associated with moderate TAC [OR 1.43 (95% CI 1.06, 1.93)] and severe TAC [OR 1.67 (95% CI 1.19, 2.36)]. Conclusions. Subjects with DISH have increased TACs, providing further evidence that patients with DISH have an increased burden of vascular calcifications.

Published
2022
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16. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Author

BAKKER, M. K., VAN DER SPEK, R. A. A., VAN RHEENEN, W., Morel, S., Bourcier, R., HOSTETTLER, I. C., ALG, V. S., VAN EIJK, K. R., KOIDO, M., Akiyama, M., TERAO, C., Matsuda, K., WALTERS, R. G., Lin, K., Li, L., MILLWOOD, I. Y., Chen, Z., Rouleau, G. A., Zhou, S., RANNIKMAE, K., SUDLOW, C. L. M., Houlden, H., VAN DEN BERG, L. H., Dina, C., Naggara, O., GENTRIC, J. C., Shotar, E., Eugene, F., DESAL, H., WINSVOLD, B. S., BORTE, S., JOHNSEN, M. B., BRUMPTON, B. M., SANDVEI, M. S., WILLER, C. J., Hveem, K., ZWART, J. A., VERSCHUREN, W. M. M., Friedrich, C. M., Hirsch, S., Schilling, S., DAUVILLIER, J., Martin, O., Jones, G. T., BOWN, M. J., KO, N. U., Kim, H., COLEMAN, J. R. I., Breen, G., ZAROFF, J. G., KLIJN, C. J. M., Malik, R., DICHGANS, M., Sargurupremraj, Muralidharan, Tatlisumak, T., Amouyel, P., Debette, Stephanie, RINKEL, G. J. E., WORRALL, B. B., Pera, J., SLOWIK, A., GAAL-PAAVOLA, E. I., NIEMELA, M., JAASKELAINEN, J. E., VON UND ZU FRAUNBERG, M., LINDGREN, A., BRODERICK, J. P., WERRING, D. J., Woo, D., REDON, R., Bijlenga, P., Kamatani, Y., VELDINK, J. H., RUIGROK, Y. M., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, cardiovascular diseases
Abstract

Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.

Published
2020
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17. Modifiable risk factors for intracranial aneurysm and aneurysmal subarachnoid hemorrhage:a Mendelian randomization study

Author

Karhunen, V. (Ville), Bakker, M. K. (Mark K.), Ruigrok, Y. M. (Ynte M.), Gill, D. (Dipender), Larsson, S. C. (Susanna C.), Karhunen, V. (Ville), Bakker, M. K. (Mark K.), Ruigrok, Y. M. (Ynte M.), Gill, D. (Dipender), and Larsson, S. C. (Susanna C.)

Abstract

Background: The aim of this study was to assess the associations of modifiable lifestyle factors (smoking, coffee consumption, sleep, and physical activity) and cardiometabolic factors (body mass index, glycemic traits, type 2 diabetes, systolic and diastolic blood pressure, lipids, and inflammation and kidney function markers) with risks of any (ruptured or unruptured) intracranial aneurysm and aneurysmal subarachnoid hemorrhage using Mendelian randomization. Methods and Results: Summary statistical data for the genetic associations with the modifiable risk factors and the outcomes were obtained from meta‐analyses of genome‐wide association studies. The inverse‐variance weighted method was used as the main Mendelian randomization analysis, with additional sensitivity analyses conducted using methods more robust to horizontal pleiotropy. Genetic predisposition to smoking, insomnia, and higher blood pressure was associated with an increased risk of both intracranial aneurysm and aneurysmal subarachnoid hemorrhage. For intracranial aneurysm, the odds ratios were 3.20 (95% CI, 1.93–5.29) per SD increase in smoking index, 1.24 (95% CI, 1.10–1.40) per unit increase in log‐odds of insomnia, and 2.92 (95% CI, 2.49–3.43) per 10 mm Hg increase in diastolic blood pressure. In addition, there was weak evidence for associations of genetically predicted decreased physical activity, higher triglyceride levels, higher body mass index, and lower low‐density lipoprotein cholesterol levels with higher risk of intracranial aneurysm and aneurysmal subarachnoid hemorrhage, with 95% CI overlapping the null for at least 1 of the outcomes. All results were consistent in sensitivity analyses. Conclusions: This Mendelian randomization study suggests that smoking, insomnia, and high blood pressure are major risk factors for intracranial aneurysm and aneurysmal subarachnoid hemorrhage.

Published
2021

18. Pulsatility attenuation along the carotid siphon in pseudoxanthoma elasticum

Author

Researchgr. Systems Radiology, Onderzoek Beeld, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Radiologie, Brain, Neurologen, Researchgr. Hart-brein as., MS Interne Geneeskunde, Highfield Research Group, Bartstra, J. W., van Tuijl, R. J., de Jong, P. A., Mali, W. P.T.M., van der Schaaf, I. C., Ruigrok, Y. M., Rinkel, G. J.E., Velthuis, B. K., Spiering, W., Zwanenburg, J. J.M., Researchgr. Systems Radiology, Onderzoek Beeld, Circulatory Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Cancer, MS Radiologie, Brain, Neurologen, Researchgr. Hart-brein as., MS Interne Geneeskunde, Highfield Research Group, Bartstra, J. W., van Tuijl, R. J., de Jong, P. A., Mali, W. P.T.M., van der Schaaf, I. C., Ruigrok, Y. M., Rinkel, G. J.E., Velthuis, B. K., Spiering, W., and Zwanenburg, J. J.M.

Published
2021

21. Residual cardiovascular risk reduction guided by lifetime benefit estimation in patients with symptomatic atherosclerotic disease: effectiveness and cost-effectiveness

Author

Hageman, Steven H J, primary, Dorresteijn, Jannick A N, additional, Bots, Michiel L, additional, Asselbergs, Folkert W, additional, Westerink, Jan, additional, van der Meulen, Miriam P, additional, Mosterd, Arend, additional, Visseren, Frank L J, additional, Asselbergs, F W, additional, Nathoe, H M, additional, de Borst, G J, additional, Bots, M L, additional, Geerlings, M I, additional, Emmelot, M H, additional, de Jong, P A, additional, Leiner, T, additional, Lely, A T, additional, van der Kaaij, N P, additional, Kappelle, L J, additional, Ruigrok, Y M, additional, Verhaar, M C, additional, Visseren, F L J, additional, and Westerink, J, additional

Published
2021
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25. The effect of computerized decision support systems on cardiovascular risk factors: a systematic review and meta-analysis

Author

Groenhof, T. Katrien J., Asselbergs, Folkert W., Groenwold, Rolf H. H., Grobbee, Diederick E., Visseren, Frank L. J., Bots, Michiel L., Nathoe, H. M., de Borst, G. J., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., and Westerink, J.

Subjects
medicine.medical_specialty, 020205 medical informatics, Health Informatics, Cardiovascular risk management, 02 engineering and technology, Disease, lcsh:Computer applications to medicine. Medical informatics, Research Support, Clinical decision support system, Health informatics, 03 medical and health sciences, 0302 clinical medicine, Journal Article, 0202 electrical engineering, electronic engineering, information engineering, Medicine, Humans, 030212 general & internal medicine, Medical Informatics Applications, Risk factor, Non-U.S. Gov't, Intensive care medicine, Risk management, Risk Management, business.industry, Research Support, Non-U.S. Gov't, Health Policy, Medical record, Computerized decision support, Decision Support Systems, Clinical, Computer Science Applications, Cardiovascular Diseases, Meta-analysis, Relative risk, lcsh:R858-859.7, CDSS, business, Research Article
Abstract

Background Cardiovascular risk management (CVRM) is notoriously difficult because of multi-morbidity and the different phenotypes and severities of cardiovascular disease. Computerized decision support systems (CDSS) enable the clinician to integrate the latest scientific evidence and patient information into tailored strategies. The effect on cardiovascular risk factor management is yet to be confirmed. Methods We performed a systematic review and meta-analysis evaluating the effects of CDSS on CVRM, defined as the change in absolute values and attainment of treatment goals of systolic blood pressure (SBP), low density lipoprotein cholesterol (LDL-c) and HbA1c. Also, CDSS characteristics related to more effective CVRM were identified. Eligible articles were methodologically appraised using the Cochrane risk of bias tool. We calculated mean differences, relative risks, and if appropriate (I2

Published
2019

26. Higher risk of intracranial aneurysms and subarachnoid haemorrhage in siblings of families with intracranial aneurysms

Author

UMC Utrecht, ZL Cerebrovasculaire Ziekten Medisch, Cardiovasculaire Epi Team 6, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Neurologie, Brain, Zuurbier, C. C.M., Greving, J. P., Rinkel, G. J.E., Ruigrok, Y. M., UMC Utrecht, ZL Cerebrovasculaire Ziekten Medisch, Cardiovasculaire Epi Team 6, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Neurologie, Brain, Zuurbier, C. C.M., Greving, J. P., Rinkel, G. J.E., and Ruigrok, Y. M.

Published
2020

31. Residual cardiovascular risk reduction guided by lifetime benefit estimation in patients with symptomatic atherosclerotic disease: effectiveness and cost-effectiveness

Author

Hageman, Steven H J, Dorresteijn, Jannick A N, Bots, Michiel L, Asselbergs, Folkert W, Westerink, Jan, van der Meulen, Miriam P, Mosterd, Arend, Visseren, Frank L J, Asselbergs, F W, Nathoe, H M, de Borst, G J, Bots, M L, Geerlings, M I, Emmelot, M H, de Jong, P A, Leiner, T, Lely, A T, van der Kaaij, N P, Kappelle, L J, Ruigrok, Y M, Verhaar, M C, Visseren, F L J, and Westerink, J

Published
2022
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32. Added value of cardiovascular calcifications for prediction of recurrent cardiovascular events and cardiovascular interventions in patients with established cardiovascular disease.

Author

van 't Klooster, Cilie C., van der Graaf, Yolanda, Nathoe, Hendrik M., Bots, Michiel L., de Borst, Gert J., Visseren, Frank L. J., Leiner, Tim, the UCC-SMART-study group, Asselbergs, F. W., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., and Ruigrok, Y. M.

Abstract

The purpose is to investigate the added prognostic value of coronary artery calcium (CAC), thoracic aortic calcium (TAC), and heart valve calcium scores for prediction of a combined endpoint of recurrent major cardiovascular events and cardiovascular interventions (MACE +) in patients with established cardiovascular disease (CVD). In total, 567 patients with established CVD enrolled in a substudy of the UCC-SMART cohort, entailing cardiovascular CT imaging and calcium scoring, were studied. Five Cox proportional hazards models for prediction of 4-year risk of MACE + were developed; traditional CVD risk predictors only (model I), with addition of CAC (model II), TAC (model III), heart valve calcium (model IV), and all calcium scores (model V). Bootstrapping was performed to account for optimism. During a median follow-up of 3.43 years (IQR 2.28–4.74) 77 events occurred (MACE+). Calibration of predicted versus observed 4-year risk for model I without calcium scores was good, and the c-statistic was 0.65 (95%CI 0.59–0.72). Calibration for models II–V was similar to model I, and c-statistics were 0.67, 0.65, 0.65, and 0.68 for model II, III, IV, and V, respectively. NRIs showed improvement in risk classification by model II (NRI 15.24% (95%CI 0.59–29.39)) and model V (NRI 20.00% (95%CI 5.59–34.92)), but no improvement for models III and IV. In patients with established CVD, addition of the CAC score improved performance of a risk prediction model with classical risk factors for the prediction of the combined endpoint MACE+. Addition of the TAC or heart valve score did not improve risk predictions. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Quantification of intracranial aneurysm volume pulsation with 7TMRI

Author

Kleinloog, R., Zwanenburg, J. J.M., Schermers, B., Krikken, E., Ruigrok, Y. M., Luijten, P. R., Visser, F., Regli, L., Rinkel, G. J.E., Verweij, B. H., Kleinloog, R., Zwanenburg, J. J.M., Schermers, B., Krikken, E., Ruigrok, Y. M., Luijten, P. R., Visser, F., Regli, L., Rinkel, G. J.E., and Verweij, B. H.

Published
2018

36. Quantification of intracranial aneurysm volume pulsation with 7TMRI

Author

ZL Cerebrovasculaire Ziekten Medisch, Highfield Research Group, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Brain, Divisie Beeld & Oncologie, Divisie Beeld, Beeldverwerking ISI, Neurologie, ZL Algemene en Acute Nec Medisch, Kleinloog, R., Zwanenburg, J. J.M., Schermers, B., Krikken, E., Ruigrok, Y. M., Luijten, P. R., Visser, F., Regli, L., Rinkel, G. J.E., Verweij, B. H., ZL Cerebrovasculaire Ziekten Medisch, Highfield Research Group, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Brain, Divisie Beeld & Oncologie, Divisie Beeld, Beeldverwerking ISI, Neurologie, ZL Algemene en Acute Nec Medisch, Kleinloog, R., Zwanenburg, J. J.M., Schermers, B., Krikken, E., Ruigrok, Y. M., Luijten, P. R., Visser, F., Regli, L., Rinkel, G. J.E., and Verweij, B. H.

Published
2018

37. The association of intracranial aneurysms and meningiomas: a hospital-based case−control study

Author

UMC Utrecht, ZL Cerebrovasculaire Ziekten Medisch, Hersenen-Medisch 2, Neurologie, Brain, Circulatory Health, Researchgr. Hart-brein as., Sluis, W. M., Rinkel, G. J.E., Velthuis, B. K., Ruigrok, Y. M., UMC Utrecht, ZL Cerebrovasculaire Ziekten Medisch, Hersenen-Medisch 2, Neurologie, Brain, Circulatory Health, Researchgr. Hart-brein as., Sluis, W. M., Rinkel, G. J.E., Velthuis, B. K., and Ruigrok, Y. M.

Published
2018

38. Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study: A Large Multicenter Clinical Biobank with Standardized Collection and Storage

Author

Van Os, H. J. A., primary, Ruigrok, Y. M., additional, Manniën, J., additional, Van Dijk, E. J., additional, Koudstaal, P. J., additional, Luijckx, G. J., additional, Nederkoorn, P. J., additional, Van Oostenbrugge, R. J., additional, Visser, M. C., additional, Kappelle, L. J., additional, Verspaget, H. W., additional, Algra, A., additional, and Wermer, M. J. H., additional

Published
2018
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40. Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain

Author

Kremer, P. H C, Koeleman, B. P C, Pawlikowska, L., Weinsheimer, S., Bendjilali, N., Sidney, S., Zaroff, J. G., Rinkel, G. J E, Van Den Berg, L. H., Ruigrok, Y. M., De Kort, G. A P, Veldink, J. H., Kim, H., Klijn, C. J M, Kremer, P. H C, Koeleman, B. P C, Pawlikowska, L., Weinsheimer, S., Bendjilali, N., Sidney, S., Zaroff, J. G., Rinkel, G. J E, Van Den Berg, L. H., Ruigrok, Y. M., De Kort, G. A P, Veldink, J. H., Kim, H., and Klijn, C. J M

Published
2015

41. Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain

Author

Genetica Groep Koeleman, Brain, Child Health, Neurologie, Projectafdeling ALS, ZL Cerebrovasculaire Ziekten Medisch, MS Radiologie, Neurogenetica, Kremer, P. H C, Koeleman, B. P C, Pawlikowska, L., Weinsheimer, S., Bendjilali, N., Sidney, S., Zaroff, J. G., Rinkel, G. J E, Van Den Berg, L. H., Ruigrok, Y. M., De Kort, G. A P, Veldink, J. H., Kim, H., Klijn, C. J M, Genetica Groep Koeleman, Brain, Child Health, Neurologie, Projectafdeling ALS, ZL Cerebrovasculaire Ziekten Medisch, MS Radiologie, Neurogenetica, Kremer, P. H C, Koeleman, B. P C, Pawlikowska, L., Weinsheimer, S., Bendjilali, N., Sidney, S., Zaroff, J. G., Rinkel, G. J E, Van Den Berg, L. H., Ruigrok, Y. M., De Kort, G. A P, Veldink, J. H., Kim, H., and Klijn, C. J M

Published
2015

42. Genome-wide association study of intracranial aneurysm identifies three new risk loci

Author

Yasuno, K., Bilguvar, K., Bijlenga, P., Low, S. K., Krischek, B., Auburger, G., Simon, M., Krex, D., Arlier, Z., Nayak, N., Ruigrok, Y. M., Niemelä, M., Tajima, A., von und zu Fraunberg, M., Dóczi, T., Wirjatijasa, F., Hata, A., Blasco, J., Oszvald, A., Kasuya, H., Zilani, G., Schoch, B., Singh, P., Stüer, C., Risselada, R., Beck, J., Sola, T., Ricciardi, F., Aromaa, A., Illig, T., Schreiber, S., van Duijn, C. M., van den Berg, L. H., Perret, C., Proust, C., Roder, C., Ozturk, A. K., Gaál, E., Berg, D., Geisen, C., Friedrich, C. M., Summers, P., Frangi, A. F., State, M. W., Wichmann, H. E., Breteler, M. M., Wijmenga, C., Mane, S., Peltonen, L., Elio, V., Sturkenboom, M. C., Lawford, P., Byrne, J., Macho, J., Sandalcioglu, E. I., Meyer, B., Raabe, A., Steinmetz, H., Rüfenacht, D., Jääskeläinen, J. E., Hernesniemi, J., Rinkel, G. J., Zembutsu, H., Inoue, I., Palotie, A., Cambien, F., Nakamura, Y., Lifton, R. P., and Günel, M.

Abstract

Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with approximately 832,000 genotyped and imputed SNPs across discovery cohorts. We identified three new loci showing strong evidence for association with intracranial aneurysms in the combined dataset, including intervals near RBBP8 on 18q11.2 (odds ratio (OR) = 1.22, P = 1.1 x 10(-12)), STARD13-KL on 13q13.1 (OR = 1.20, P = 2.5 x 10(-9)) and a gene-rich region on 10q24.32 (OR = 1.29, P = 1.2 x 10(-9)). We also confirmed prior associations near SOX17 (8q11.23-q12.1; OR = 1.28, P = 1.3 x 10(-12)) and CDKN2A-CDKN2B (9p21.3; OR = 1.31, P = 1.5 x 10(-22)). It is noteworthy that several putative risk genes play a role in cell-cycle progression, potentially affecting the proliferation and senescence of progenitor-cell populations that are responsible for vascular formation and repair.

Published
2010

45. Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain

Author

Kremer, P H C, primary, Koeleman, B P C, additional, Pawlikowska, L, additional, Weinsheimer, S, additional, Bendjilali, N, additional, Sidney, S, additional, Zaroff, J G, additional, Rinkel, G J E, additional, van den Berg, L H, additional, Ruigrok, Y M, additional, de Kort, G A P, additional, Veldink, J H, additional, Kim, H, additional, and Klijn, C J M, additional

Published
2014
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46. Genetic risk load according to the site of intracranial aneurysms

Author

van 't Hof, F. N. G., primary, Kurki, M. I., additional, Kleinloog, R., additional, de Bakker, P. I. W., additional, von und zu Fraunberg, M., additional, Jaaskelainen, J. E., additional, Gaal, E. I., additional, Lehto, H., additional, Kivisaari, R., additional, Laakso, A., additional, Niemela, M., additional, Hernesniemi, J., additional, Brouwer, M. C., additional, van de Beek, D., additional, Rinkel, G. J. E., additional, and Ruigrok, Y. M., additional

Published
2014
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47. Association of the TGF-β receptor genes with abdominal aortic aneurysm

Author

Baas, A F, primary, Medic, J, additional, van 't Slot, R, additional, de Kovel, C G, additional, Zhernakova, A, additional, Geelkerken, R H, additional, Kranendonk, S E, additional, van Sterkenburg, S M, additional, Grobbee, D E, additional, Boll, A P, additional, Wijmenga, C, additional, Blankensteijn, J D, additional, and Ruigrok, Y M, additional

Published
2009
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