183 results on '"Ruifang Chen"'
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2. Comparative genomics analysis of Streptococcus iniae isolated from Trachinotus ovatus: novel insight into antimicrobial resistance and virulence differentiation
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Xiangying Xiong, Ruifang Chen, and Junxiang Lai
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Streptococcus iniae ,Comparative genomics ,Antibiotic resistance ,Virulence ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background Streptococcus iniae is an important fish pathogen that cause significant economic losses to the global aquaculture industry every year. Although there have some reports on the genotype of S.iniae and its relationship with virulence, no genome-scale comparative analysis has been performed so far. In our previous work, we characterized 17 isolates of S.iniae from Trachinotus ovatus and divided them into two genotypes using RAPD and rep-PCR methods. Among them, BH15-2 was classified as designated genotype A (in RAPD) and genotype 1 (in rep-PCR), while BH16-24 was classified as genotype B and genotype 2. Herein, we compared the differences in growth, drug resistance, virulence, and genome between BH15-2 and BH16-24. Results The results showed that the growth ability of BH16-24 was significantly faster than that of BH15-2 at the exponential stage. Antimicrobial tests revealed that BH15-2 was susceptible to most of the tested antibiotics except neomycin and gentamycin. In contrast, BH16-24 was resistant to 7 antibiotics including penicillin, sulfasomizole, compound sulfamethoxazole tablets, polymyxin B, spectinomycin, rifampin and ceftazidime. Intraperitoneal challenge of T.ovatus, showed that the LD50 value of BH15-2 was 4.0 × 102 CFU/g, while that of BH16-24 was 1.2 × 105 CFU/g. The genome of S.iniae BH15-2 was 2,175,659 bp with a GC content of 36.80%. Meanwhile, the genome of BH16-24 was 2,153,918 bp with a GC content of 36.83%. Comparative genome analysis indicated that compared with BH15-2, BH16-24 genome had a large-scale genomic inversion fragment, at the location from 502,513 bp to 1,788,813 bp, resulting in many of virulence and resistance genes differentially expression. In addition, there was a 46 kb length, intact phage sequence in BH15-2 genome, which was absent in BH16-24. Conclusion Comparative genomic studies of BH15-2 and BH16-24 showed that the main difference is a 1.28 Mbp inversion fragment. The inversion fragment may lead to abnormal expression of drug resistant and virulence genes, which is believed to be the main reason for the multiple resistance and weakened virulence of BH16-24. Our study revealed the potential mechanisms in underlying the differences of multidrug resistance and virulence among different genotypes of S.iniae.
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- 2023
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3. Prognostic significance and risk factors for pelvic and para-aortic lymph node metastasis in type I and type II ovarian cancer: a large population-based database analysis
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Hailin Yu, Jieyu Wang, Beibei Wu, Jun li, and Ruifang Chen
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Ovarian cancer ,Two-tier classification system ,Lymph node metastasis ,Para-aortic lymph nodes ,Pelvic lymph nodes ,Prognosis ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background To compare the prognosis of lymphatic metastasis in type I and type II epithelial ovarian cancer (OC) and to identify the risk factors for pelvic lymph node metastases (PLNs) and para-aortic lymph node metastases (PALNs). Methods Patients diagnosed with epithelial OC were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and cancer-specific survival (CSS) were estimated. The Cox proportional hazards regression model was used to identify independent predictors of survival. Results A total of 11,275 patients with OC were enrolled, including 31.2% with type I and 68.8% with type II. Type II and high tumour stage were risk factors for lymph node involvement (p 0.05). For the type II group, the 10-year CSS rates of LN(-), PLN( +), PALN( +), and PLN + PALN( +) were 55.6%, 18.5%, 25.7%, and 18.2%, respectively. PALN ( +) had a significantly better prognosis than PLN ( +) in the type II group (p
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- 2023
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4. Towards effective wildlife protection law for marine species in China: A stakeholders’ perspective
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Kit Yue Kwan, Ruifang Chen, Chun-Chieh Wang, Shuhao Lin, Lv Wu, Xiaoyong Xie, Zhaohong Weng, Menghong Hu, Haichao Zhou, Zhou Wu, Yijian Fu, Wenquan Zhen, Xin Yang, and Yulong Wen
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biodiversity conservation ,biological resources ,bottom-up approach ,fisher ,legislative intervention ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
IntroductionAs one of the megadiverse countries, the effectiveness of wildlife protection in China is of great significance to global biodiversity conservation. With continued evolution and revisions, China’s Wildlife Protection Law has listed over 140 marine species; however, it is still inclined toward terrestrial animals.MethodsTo narrow the gap between compliance and enforcement, we collected 1,309 effective responses from various coastal cities of China through an anonymous online questionnaire survey, to investigate their exposure, understanding and attitudes toward Wildlife Protection Law for marine species (mWPL).ResultsMost respondents demonstrated an overall good understanding about the context, necessity and effectiveness of mWPL. The fisher communities were found to be more aware of the dissemination and implementation of mWPL. However, they understood less of the penal system, and exhibited negative attitudes toward the necessity and punishment of the legislation, probably due to the conflicts between resource utilizations and legislative interventions. The participants also indicated that seahorses, horseshoe crabs and corals were commonly subjected to illegal exploitations.DiscussionWhile most respondents suggested greater fines, tighter laws and better public enforcement, we advocate the exploration of bottom-up options such as community engagement and environmental education to improve compliance and implementation of mWPL for the benefit of marine wildlife conservation in China.
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- 2023
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5. Quantitative Analysis of the Uncertainty of Drought Process Simulation Based on Atmospheric–Hydrological Coupling in Different Climate Zones
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Huating Xu, Zhiyong Wu, Hai He, Ruifang Chen, and Xiaotao Wu
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uncertainty of drought simulation ,soil moisture ,atmospheric–hydrological coupling ,quantitative analysis ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
Droughts can lead to drought disasters, which have become one of the main natural disasters affecting the development of social economies and ecological environments around the world. Timely and effective drought process simulation and prediction based on atmospheric–hydrological coupling is crucial for drought prevention and resistance. The initial condition (IC) is one source causing uncertainty in drought process simulation and prediction, and the impacts are different with drought duration, basin size and region. Therefore, a quantitative method that measures the uncertainty caused by ICs on the drought process simulation in different climate zones is proposed in this study. In this study, the VIC (Variable Infiltration Capacity) model at a resolution of 0.05°, which is proven as an ideal model to reflect drought processes, was used as the hydrological model to obtain soil moisture. By analyzing the Soil Moisture Anomaly Percentage Index (SMAPI) error characteristics that were simulated based on different ICs, an uncertainty index for drought process simulation was constructed in different climate zones. It was found that with the development of a drought process, the uncertainty converges, and it decreases to within 10% after a drought occurs for 5 to 6 months, while it is less than 5% in the particular basin in a humid region. In climate transition zones, both the uncertainty and its decrease rate are greater than those in humid regions. Climate characteristics, as well as soil types and vegetation types, are fundamental factors that cause differences in drought process simulation and uncertainty changes. The precipitation and temperature distribution more obviously vary spatially and temporally, a greater uncertainty is caused by ICs. This quantitative method reveals the impact of ICs on drought process simulation in different climate regions and provides a basis for the further improvement of drought simulation and prediction based on atmospheric–hydrological coupling.
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- 2023
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6. Dynamic changes in species richness and community diversity of symbiotic bacteria in five reproductive morphs of cotton aphid Aphis gossypii Glover (Hemiptera: Aphididae)
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Ruifang Chen, Junyu Luo, Xiangzhen Zhu, Li Wang, Kaixin Zhang, Dongyang Li, Xueke Gao, Lin Niu, Ningbo Huangfu, Xiaoyan Ma, Jichao Ji, and Jinjie Cui
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symbiotic bacteria ,16S rRNA ,Arsenophonus ,Aphis gossypii ,reproductive polymorphism ,Microbiology ,QR1-502 - Abstract
IntroductionReproductive polymorphism and symbiotic bacteria are commonly observed in aphids, but their interaction remains largely unclear. In polymorphic aphid species (Aphis gossypii), offspring of parthenogenetic females (PFs) develops into sexuparae which produces gynoparae and males successively. Gynoparae further produces sexual females (SFs), and these sexual females mate with males to produce offspring.MethodsIn this study, we investigated the dynamic changes of symbiotic bacteria during the above-mentioned five reproductive morph switch in A. gossypii via 16S rRNA sequencing technology.ResultsThe results showed that species richness and community diversity of symbiotic bacteria in males were the highest. Proteobacteria was absolutely dominant bacterial phylum (with relative abundance of more than 90%) in the five reproductive morphs of A. gossypii, and Buchnera was absolutely dominant genus (with relative abundance of >90%), followed by Rhodococcus, Pseudomonas, and Pantoea. Male-killing symbiont Arsenophonus presented the highest relative abundance in gynoparae, a specific morph whose offsprings were exclusively sexual females. Both principal component analysis (PCA) and clustering analysis showed trans-generation similarity in microbial community structure between sexuparae and sexual females, between PFs and gynoparae. PICRUSt 2 analysis showed that symbiotic bacteria in the five reproductive morphs were mainly enriched in metabolic pathways.DiscussionReproductive morph switch induced by environmental changes might be associated with bacterial community variation and sexual polymorphism of aphids. This study provides a new perspective for further deciphering the interactions between microbes and reproductive polymorphism in host aphids.
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- 2023
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7. Bevacizumab confers significant improvements in survival for ovarian cancer patients with low miR-25 expression and high miR-142 expression
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Jun Li, Huiran Yue, Wenzhi Li, Guohua Zhu, Tingting Zhu, Ruifang Chen, and Xin Lu
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Ovarian cancer ,Lymphovascular space invasion ,MicroRNA ,Bevacizumab ,Prognosis ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Lymphovascular space invasion (LVSI) is the first step of hematogenous metastasis. Exploration of the differential miRNA expression profiles between LVSI-positive and LVSI-negative ovarian cancer tissues may help to identify key miRNAs involved in the hematogenous metastasis of ovarian cancer. This study is aimed to identify microRNAs (miRNAs) that are differentially expressed between LVSI-positive and LVSI-negative ovarian cancer tissues, followed by exploring their association with bevacizumab response in ovarian cancer patients. Methods The Cancer Genome Altas (TGGA) dataset was used to identify the differentially expressed miRNAs between LVSI-positive and LVSI-negative ovarian cancer tissues. The prognostic value of the differentially expressed miRNAs was determined using GSE140082 dataset. Results We showed that miR-25 and miR-142 were differentially expressed between LVSI-positive and LVSI-negative ovarian cancer tumors. Kaplan-Meier analysis indicated that high miR-25 expression was associated with increased progression free survival (PFS) and extended overall survival (OS). Moreover, patients with low miR-25 expression benefited significantly from bevacizumab treatment in terms of PFS. A similar trend was observed in terms of OS though without reaching statistical significance. In contrast, no significant survival benefits from bevacizumab were observed in patients with high miR-25 expression in terms of PFS and OS. There was no significant correlation between miR-142 expression and PFS. In contrast, high miR-142 expression was associated with reduced OS. Moreover, patients with high miR-142 expression benefited significantly from bevacizumab treatment in terms of PFS and OS. However, bevacizumab treatment conferred no significant improvements in both PFS and OS in patients with low miR-142 expression. The nomogram for PFS indicated that miR-25 expression had a larger contribution to PFS than debulking status and bevacizumab treatment. And the nomogram for OS illustrated both miR-25 expression and miR-142 expression as sharing a larger contribution to OS than bevacizumab treatment and debulking status. Conclusion In conclusion, miR-25 expression correlates with a better PFS and OS in ovarian cancer. Patients with low miR-25 expression and high miR-142 expression could benefit from bevacizumab treatment significantly.
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- 2021
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8. Significant Improvement of LiMn2O4 Cathode Capacity by Introducing Trace Ni During Rapid Microwave-induced Solution Combustion
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Ruifang CHEN, BiXia WEN, Changwei SU, Wei BAI, and Junming GUO
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microwave ,limn2o4 ,lithium-ion battery ,ni-doping ,Technology ,Physical and theoretical chemistry ,QD450-801 - Abstract
LiMn2O4 cathodes are prepared by a rapid microwave-induced solution combustion method. Their initial discharge capacity is significantly improved by introducing trace Ni. For example, the LiMn1.975Ni0.025O4 (LMNO-0.025) cathode releases an initial discharge capacity of 134.1 mAh g−1 at 1 C, even 144.5 mAh g−1 at 0.5 C, which is far higher than of the pristine LiMn2O4 cathode (119.7 mAh g−1 at 1 C) and close to its theoretical capacity of 148.2 mAh g−1. After 1000 cycles, the capacity retention of the LMNO-0.025 sample reaches 56.53 % at 1 C, and it can be presented the higher capacity retentions of 66.79 % at 5 C and 66.89 % at 20 C. The robust structure stability proved by XRD, SEM and HRTEM data, and the good kinetics testified by CV and EIS data of the Ni-doped material are responsible to improve the high-rate capability and long cycle properties.
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- 2020
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9. The prognostic value of ITGA and ITGB superfamily members in patients with high grade serous ovarian cancer
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Tingting Zhu, Ruifang Chen, Jieyu Wang, Huiran Yue, Xin Lu, and Jun Li
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High grade serous ovarian cancer ,Integrin ,ITGA ,ITGB ,Prognosis ,Nomogram ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Background Deregulation of integrins signaling had been documented to participate in multiple fundamental biological processes, and the aberrant expression of integrin family members were linked to the prognosis of various cancers. However, the role of integrins in predicting progression and prognosis of ovarian cancer patients are still largely elusive. This study is aimed to explore the prognostic values of ITGA and ITGB superfamily members in high grade serous ovarian cancers (HGSOC). Methods GSE26712 dataset was used to determine the differential expression of ITGA and ITGB superfamily member between HGSOC and normal counterparts. The Cancer Genome Altas (TGGA) and GSE9891 datasets were used to determine the prognostic values of ITGA and ITGB superfamily members in HGSOC, followed by the development of nomograms predictive of recurrence free survival (RFS) and overall survival (OS). Results ITGA6 and ITGB5 expression were significantly downregulated in HGSOC compared with that in normal counterparts. In contrast, ITGA2, ITGA5, ITGA7, ITGA8, ITGA9, ITGA10, ITGB3, ITGB4, ITGB6, and ITGB8 were all significantly upregulated in HGSOC compared with that in normal counterparts. Both univariable and multivariable analysis indicated that ITGB1 was associated with extended RFS. The ITGB1-related nomogram indicated that ITGB1 had the largest contribution to RFS, followed by FIGO stage and debulking status. The C-index for predicting RFS was 0.55 (95% CI 0.50–0.59) in TCGA dataset (training dataset) and 0.65 (95% CI 0.59–0.72) in GSE9891 dataset (validation dataset), respectively. Regarding OS, ITGB8 was associated with reduced survival suggested by both univariable and multivariable analysis. ITGA7 appeared to be associated with improved survival though without reaching statistical significance. The ITGA7/ITGB8-based nomogram showed that age at initial diagnosis had the largest contribution to OS, followed by ITGB8 and ITGA7 expression. The C-index for predicting OS was 0.65 (95% CI 0.60–0.69) in TCGA dataset (training dataset) and 0.59 (95% CI 0.51–0.66) in GSE9891 dataset (validation dataset), respectively. Conclusion In conclusion, ITGB1, ITGA7 and ITGB8 added prognostic value to the traditional clinical risk factors used to assess the clinical outcomes of HGSOC.
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- 2020
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10. Health Effects of Metabolic Risks in the United States From 1990 to 2019
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Ruifang Chen, Saeid Safiri, Masoud Behzadifar, Jude Dzevela Kong, Mohamed Sami Zguira, Nicola Luigi Bragazzi, Wen Zhong, and Weiru Zhang
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metabolic risk ,disability adjusted life year ,death ,United States ,global burden of disease ,Public aspects of medicine ,RA1-1270 - Abstract
IntroductionMetabolic risks including high body mass index, high fasting plasma glucose, high low-density lipoprotein cholesterol, high systolic blood pressure, kidney dysfunction and low bone mineral density, contribute heavy burden to the US health systems. We aimed to investigate the burden attributable to metabolic risks in the US from 1990 to 2019.MethodsUsing methodology of Global Burden of Disease Study, the deaths and DALYs attributable to metabolic risks were analyzed by age, gender, states, Socio-demographic Index (SDI) and diseases from 1990 to 2019 in the US.ResultsIn 2019, the age-standardized death and DALY rates attributable to metabolic risks were 174.9 and 4738.7 per 100,000 people, accounting for 33.1% and 18.2% of death and DALY rates from all causes in the US, and there was a decrease by −32.5% and −21.2% in age-standardized death and DALY rates since 1990. The burden attributable to metabolic risks increased with age, and was higher in males than females. In addition, the burden varied widely across the states, generally in inverse proportion to the SDI levels, and the heaviest burden was observed in East and West South-Central of the US. Cardiovascular diseases carried heavy burden attributable to metabolic risks.ConclusionThe burden attributable to metabolic risks remained major public health concerns in the US. Prevention of metabolic risks should be a high priority in the US.
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- 2022
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11. Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer
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Huiran Yue, Jieyu Wang, Ruifang Chen, Xiaoman Hou, Jun Li, and Xin Lu
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Hematogenous and lymphatic metastasis ,Lymphovascular space invasion ,Tumor stroma ,Cancer-associated fibroblast ,Ovarian cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The clinical significance of hematogenous and lymphatic metastasis in ovarian cancer has been increasingly addressed, as it plays an imperative role in the formation of both intraperitoneal and distant metastases. Our objective is to identify the key molecules and biological processes potentially related to this relatively novel metastatic route in serous ovarian cancer. Methods Since lymphovascular space invasion (LVSI) is considered as the first step of hematogenous and lymphatic dissemination, we developed a gene signature mainly based on the transcriptome profiles with available information on LVSI status in the Cancer Genome Atlas (TCGA) dataset. We then explored the underlying biological rationale and prognostic value of the identified gene signature using multiple public databases. Results We observe that primary tumors with increased risk of hematogenous and lymphatic metastasis highly express a panel of genes, namely POSTN, LUM, THBS2, COL3A1, COL5A1, COL5A2, FAP1 and FBN1. The identified geneset is characterized by enhanced deposition of extracellular matrix and extensive stromal activation. Mechanistically, both the recruitment and the activation of stromal cells, especially fibroblasts, are closely associated with lymphovascular metastasis. Survival analysis further reveals that the elevated expression of the identified genes correlates to cancer progression and poor prognosis in patients with serous ovarian cancer. Conclusions Our findings indicate that tumor stroma supports the hematogenous and lymphatic spread of ovarian cancer, increasing tumor invasiveness and ultimately resulting in worse survival. Thus stroma-targeted therapies may improve the clinical outcomes in combination with cytoreductive surgery and chemotherapy.
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- 2019
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12. S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1
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Wei Chen, Hong Xiang, Ruifang Chen, Jie Yang, Xiaoping Yang, Jianda Zhou, Hengdao Liu, Shaoli Zhao, Jie Xiao, Pan Chen, Alex F. Chen, Shuhua Chen, and Hongwei Lu
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Sphingosine-1-phosphate receptor 2 ,Diabetes ,Mitochondria ,Endothelial cell ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Aims Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothelial cell dysfunction remains unclear. This study aims to investigate the effect of S1PR2 blockade on the morphology and function of mitochondria in human renal glomerular endothelial cells (HRGECs). Methods HRGECs were pretreated with a S1PR2 antagonist (JTE-013) or a Rho-associated coiled coil-containing protein kinase 1 (ROCK1) inhibitor (Y27632) for 30 min and then cultured with normal glucose (5.5 mM) or high glucose (30 mM) for 72 h. The protein expression levels of RhoA, ROCK1, and Dynmin-related protein-1(Drp1) were evaluated by immunoblotting; mitochondrial morphology was observed by electron microscopy; intracellular levels of ATP, ROS, and Ca2+ were measured by ATPlite, DCF-DA, and Rhod-2 AM assays, respectively. Additionally, the permeability, apoptosis, and migration of cells were determined to evaluate the effects of S1PR2 and ROCK1 inhibition on high glucose-induced endothelial dysfunction. Results High glucose induced mitochondrial fission and dysfunction, indicated by increased mitochondrial fragmentation, ROS generation, and calcium overload but decreased ATP production. High glucose also induced endothelial cell dysfunction, indicated by increased permeability and apoptosis but decreased migration. However, inhibition of either S1PR2 or ROCK1 almost completely blocked these high glucose-mediated cellular responses. Furthermore, inhibiting S1PR2 resulted in the deceased expression of RhoA, ROCK1, and Drp1 while inhibiting ROCK1 led to the downregulated expression of Drp1. Conclusions S1PR2 antagonist modulates the morphology and function of mitochondria in HRGECs via the positive regulation of the RhoA/ROCK1/Drp1 signaling pathway, suggesting that the S1PR2/ROCK1 pathway may play a crucial role in high glucose milieu.
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- 2019
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13. Gender-specific associations between apolipoprotein A1 and arterial stiffness in patients with nonalcoholic fatty liver disease
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Xulong Sun, Ruifang Chen, Guangyu Yan, Zhiheng Chen, Hong Yuan, Wei Huang, and Yao Lu
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Non-alcoholic fatty liver disease ,Arterial stiffness ,ApoA1 ,Gender ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background Lipid metabolism factors may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD) and its related cardiovascular dysfunctions. The study aims to assess whether Apolipoprotein A-1 (ApoA1) was associated with vascular stiffness in NAFLD patients. Methods From 2012 to 2013, we included 2,295 non-alcohol users with fatty liver disease (1,306 male patients) and completely excluded subjects who drank any alcohol ever to eliminate the effect of alcohol intake. The serum ApoA1 levels and the brachial-ankle pulse wave velocity (baPWV) were measured. Results The baPWV in men was much higher than in female patients (1,412.79 cm/s vs. 1,358.69 cm/s, P < 0.001). ApoA1 level was positively associated with baPWV odd ratio (OR), 4.18; 95% confidence interval (CI) [1.16–15.1], P < 0.05) in patients with AST/ALT < 1 and (OR, 4.70; 95% CI [1.36–16.23], P < 0.05) in patients with AST/ALT ≥ 1 respectively. Only arterial stiffness in men was associated with ApoA1 (OR, 3.96; 95% CI [1.29–12.30], P < 0.05) in logistics regression models adjusted for age, gender, body mass index, education attainment, physical activity, smoking, history of hypertension and high-density lipoprotein. The relationship between ApoA1 and baPWV in male NAFLD patients remained significant (confidence, 156.42; 95% CI [49.34–263.50], P < 0.05) in the fully adjusted linear regression model. Conclusion The serum ApoA1 was associated with arterial stiffness in male NAFLD patients. Increased ApoA1 level should be considered as an independent risk factor for arterial stiffness in male NAFLD patients, suggesting that NAFLD may alter arterial stiffness by “ApoA1-related” mechanism in men.
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- 2020
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14. Survival effect of different lymph node staging methods on ovarian cancer: An analysis of 10 878 patients
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Jieyu Wang, Jun Li, Ruifang Chen, and Xin Lu
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epithelial ovarian cancer ,log odds of positive lymph nodes ,lymph node ratio ,lymphadenectomy ,resected lymph nodes ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background To compare the survival impact of several lymph node staging methods and therapeutic role of lymphadenectomy in patients with epithelial ovarian cancer who had undergone lymphadenectomy. Methods Data were retrospectively collected from the Surveillance, Epidemiology, and End Results program between 1988 and 2013. Results An increasing number of resected lymph nodes (RLNs) was associated with a significant improvement in survival of FIGO stage II and III disease. However, for FIGO stage IV patients, better survival was not significantly associated with a more extensive lymphadenectomy. A higher lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) were associated with poorer survival regardless of stage. Nevertheless, four‐category classification of LODDS was more suitable for stage IV patients when three‐category classification was compatible with stage I‐III disease. Multivariate analysis demonstrated that LODDS and LNR were significant independent prognostic factors, but not RLN classification. Conclusion Sixteen to thirty RLNs are recommended for stage I disease. For stages II and III patients, the more lymph node excision, the better the prognosis. However, lymphadenectomy was nonessential for stage IV patients. Considering staging methods, for stages II and III patients, three‐category classification of LODDS was recommended to evaluate the prognosis. For stage I and IV, three‐category classification of positive LNR was idoneous.
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- 2018
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15. Lipid accumulation product is a powerful tool to predict non-alcoholic fatty liver disease in Chinese adults
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Haijiang Dai, Weijun Wang, Ruifang Chen, Zhiheng Chen, Yao Lu, and Hong Yuan
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LAP ,NAFLD ,Severity ,General population ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Non-alcoholic fatty liver disease (NAFLD), recognized as the liver manifestation of metabolic syndrome, is highly prevalent in the general population. Recent studies suggest that lipid accumulation product is significantly associated with metabolic abnormalities. The aim of this study was to assess the accuracy of lipid accumulation product (LAP) as an effective screening tool for diagnosing NAFLD in the general population. Methods A total of 40,459 subjects aged ≥18 years were enrolled in this cross-sectional study. LAP was calculated as [waist circumference (cm) – 65] × triglyceride concentration (mmol//L) in men and [waist circumference (cm) – 58] × triglyceride concentration (mmol/L) in women. Multiple logistic regression and receiver operating characteristic (ROC) analyses were performed. Results According to multiple logistic regression analyses, LAP was significantly associated with a higher prevalence and severity of NAFLD in both men and women. When assessed using ROC curve analyses, LAP exhibited high diagnostic accuracy for identifying NAFLD, and the areas under the curves (AUC) in men and women were 0.843 (95% CI 0.837, 0.849) and 0.887 (95% CI 0.882, 0.892), respectively. After further analyzed in different age groups, the diagnostic accuracy of LAP was found to be significantly better in younger age groups (aged 18-34 for men; aged 18-34 and 35-44 years for women) for both sexes. Conclusions LAP is significantly associated with the presence and severity of NAFLD, and has a high diagnostic accuracy for identifying NAFLD in the general population. The diagnostic accuracy of LAP was especially high among younger age groups.
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- 2017
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16. A retrospective study of reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors and sex cord-stromal tumors
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Ning Zhang, Ruifang Chen, Keqin Hua, and Ying Zhang
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Malignant germ cell tumors ,Malignant sex cord-stromal tumors ,Fertility-sparing surgery ,Postoperative adjuvant chemotherapy ,Reproductive outcomes ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). Methods Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed. Results Average follow up was (86.3 ± 34.4) months. Average diagnosed age was (25.3 ± 3.5) years. Average chemotherapy course was (4.4 ± 1.3) times. Patients are all living. Thirty one patients (75.6%) reported normal menstrual cycles. Twelve patients (29.3%) wished to conceive, 10 (83.3%) naturally conceived and 8 (66.7%) had lived birth. Conclusions Reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in MOGCT and SCST are favorable, meanwhile education and consultation is needed.
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- 2017
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17. What is the impact of PCSK9 rs505151 and rs11591147 polymorphisms on serum lipids level and cardiovascular risk: a meta-analysis
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Chengfeng Qiu, Pingyu Zeng, Xiaohui Li, Zhen Zhang, Bingjie Pan, Zhou Y. F. Peng, Yapei Li, Yeshuo Ma, Yiping Leng, and Ruifang Chen
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Proprotein convertase subtilisin/kexin type 9 ,Polymorphisms ,Cardiovascular risk ,Lipids ,Meta-analysis ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background PCSK9 rs505151 and rs11591147 polymorphisms are identified as gain- and loss-of-function mutations, respectively. The effects of these polymorphisms on serum lipid levels and cardiovascular risk remain to be elucidated. Methods In this meta-analysis, we explored the association of PCSK9 rs505151 and rs11591147 polymorphisms with serum lipid levels and cardiovascular risk by calculating the standardized mean difference (SMD) and odds ratios (OR) with 95% confidence intervals (CI). Results Pooled results analyzed under a dominant genetic model indicated that the PCSK9 rs505151 G allele was related to higher levels of triglycerides (SMD: 0.14, 95% CI: 0.02 to 0.26, P = 0.021, I2 = 0) and low-density lipoproteins cholesterol (LDL-C) (SMD: 0.17, 95% CI: 0.00 to 0.35, P = 0.046, I2 = 75.9%) and increased cardiovascular risk (OR: 1.50, 95% CI: 1.19 to 1.89, P = 0.0006, I2 = 48%). The rs11591147 T allele was significantly associated with lower levels of total cholesterol (TC) and LDL-C (TC, SMD: -0.45, 95% CI: -0.57 to −0.32, P = 0.000, I2 = 0; LDL-C, SMD: -0.44, 95% CI: -0.55 to −0.33, P = 0.000, I2 = 0) and decreased cardiovascular risk (OR: 0.77, 95% CI: 0.60 to 0.98, P = 0.031, I2 = 59.9) in Caucasians. Conclusions This study indicates that the variant G allele of PCSK9 rs505151 confers increased triglyceride (TG) and LDL-C levels, as well as increased cardiovascular risk. Conversely, the variant T allele of rs11591147 protects carriers from cardiovascular disease susceptibility and lower TC and LDL-C levels in Caucasians. These findings provide useful information for researchers interested in the fields of PCSK9 genetics and cardiovascular risk prediction not only for designing future studies, but also for clinical and public health applications.
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- 2017
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18. Visit-to-visit Variability of Blood Pressure and Risk of Stroke: Results of the Kailuan Cohort Study
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Haijiang Dai, Yao Lu, Lu Song, Xiaohong Tang, Ying Li, Ruifang Chen, Aijing Luo, Hong Yuan, and Shouling Wu
- Subjects
Medicine ,Science - Abstract
Abstract Uncertainty persists regarding the need to address blood pressure (BP) variability in the general population to reduce the heavy burden of stroke. In this cohort study, we prospectively recruited 57,927 participants from southeast of Beijing, who have completed all 3 health examinations between 2006 and 2010. BP variability was defined as the coefficient of variation (CV) across these 3 visits. Over a median follow-up of 3.0 years, we identified 582 first stroke cases. Of these, 489 (84.0%) were ischemic strokes and 94 (16.2%) were hemorrhagic strokes. After multivariable adjustment, the hazard ratios (HR) (95% Confidence Intervals, CI) of comparing participants in the highest versus lowest quartile of CV of systolic blood pressure (SBP) was 1.44 (1.11, 1.87) for any stroke, 1.33 (1.00, 1.77) for ischemic stroke, and 2.17 (1.09, 4.35) for hemorrhagic stroke. Similar results were also observed when the CV of SBP was considered as a continuous exposure variable (per SD increase). Moreover, higher variability of diastolic blood pressure (DBP) was also significantly associated with the risk of any stroke and specifically with hemorrhagic stroke, but not with ischemic stroke. In conclusion, higher visit-to-visit BP variability might be an important target to reduce stroke risk, particularly for hemorrhagic stroke.
- Published
- 2017
- Full Text
- View/download PDF
19. Combined Association of Serum Uric Acid and Metabolic Syndrome with Chronic Kidney Disease in Hypertensive Patients
- Author
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Haijiang Dai, Shijuan Lu, Xiaohong Tang, Minggen Lu, Ruifang Chen, Zhiheng Chen, Pingting Yang, Chang Liu, Honghao Zhou, Yao Lu, and Hong Yuan
- Subjects
Chronic kidney disease ,Serum uric acid ,Hyperuricemia ,Metabolic syndrome ,Hypertension ,Dermatology ,RL1-803 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Background/Aims: Chronic kidney disease (CKD) is one of the major complications of hypertension. It is not only associated with the future burden of end-stage renal disease but also affects mortality and cardiovascular outcomes caused by hypertension. To help understand the pathogenesis and early prevention of progressive CKD, this large-scale study is designed to determine the complex association between serum uric acid (SUA), metabolic syndrome and the prevalence of CKD in hypertensive patients. Methods: A total of 19,848 hypertensive subjects were enrolled in this cross-sectional study. Patients with proteinuria and/or an estimated glomerular filtration rate (eGFR) of 2 were considered CKD cases. Results: Hypertensive subjects with CKD had a higher prevalence of hyperuricemia and metabolic syndrome, as well as higher levels of SUA, BMI, waist circumference (WC), SBP, DBP, TG, fasting blood glucose and lower levels of HDL-C. Compared to patients without CKD, the multivariate-adjusted odds ratios [ORs, 95% confidence interval (CI)] for CKD patients were 2.30 (2.02-2.63) for hyperuricemia, 1.21 (1.04-1.41) for abdominal obesity, 1.21 (1.06-1.38) for elevated TG, 1.29 (1.06-1.56) for low HDL-C, 1.54 (1.36-1.75) for elevated fasting glucose, and 1.49 (1.30-1.71) for metabolic syndrome. Increasing SUA levels and number of individual metabolic syndrome components were associated with an increased prevalence of CKD. Compared with patients classified in the lowest SUA categories and with ≤1 metabolic syndrome components, subjects with HUA and 4 metabolic syndrome components had a 5.77-fold increased OR for CKD based on the multivariate-adjusted analysis. Conclusion: Both elevated SUA and metabolic syndrome are associated with an increased prevalence of CKD in hypertensive subjects. Subjects with higher SUA and sum of individual metabolic syndrome components simultaneously have a higher prevalence of CKD.
- Published
- 2016
- Full Text
- View/download PDF
20. Readability and Content Assessment of Informed Consent Forms for Phase II-IV Clinical Trials in China.
- Author
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Gaiyan Wen, Xinchun Liu, Lihua Huang, Jingxian Shu, Nana Xu, Ruifang Chen, Zhijun Huang, Guoping Yang, Xiaomin Wang, Yuxia Xiang, Yao Lu, and Hong Yuan
- Subjects
Medicine ,Science - Abstract
To explore the readability and content integrity of informed consent forms (ICFs) used in China and to compare the quality of Chinese local ICFs with that of international ICFs.The length, readability and content of 155 consent documents from phase II-IV drug clinical trials from the Third Xiangya Hospital Ethics Committee from November 2009 to January 2015 were evaluated. Reading difficulty was tested using a readability formula adapted for the Chinese language. An ICF checklist containing 27 required elements was successfully constructed to evaluate content integrity. The description of alternatives to participation was assessed. The quality of ICFs from different sponsorships were also compared.Among the 155 evaluable trials, the ICFs had a median length of 5286 words, corresponding to 7 pages. The median readability score was 4.31 (4.02-4.41), with 63.9% at the 2nd level and 36.1% at the 3rd level. Five of the 27 elements were frequently neglected. The average score for the description of alternatives to participation was 1.06, and 27.7% of the ICFs did not mention any alternatives. Compared with Chinese local ICFs, international ICFs were longer, more readable and contained more of the required elements (P < 0.05).The ICFs used in China were difficult to read for most participants. These forms had poor description of alternatives to participation, and failed to provide a high degree of information disclosure, including an explanation of informed consent, follow-up processing of the data/sample, inclusion/exclusion criteria, double blinding, and unpredictable risks. International ICFs had better readability and content integrity than Chinese local ICFs. More efforts should thus be made to improve the quality of consent documents in China.
- Published
- 2016
- Full Text
- View/download PDF
21. Structural and Electrical Studies on ZnO-Based Thin Films by Laser Irradiation
- Author
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Shanyue Zhao, Yinqun Hua, Ruifang Chen, Jian Zhang, and Ping Ji
- Subjects
Technology (General) ,T1-995 - Abstract
The effects of laser irradiation on the structural and electrical properties of ZnO-based thin films were investigated. The XRD pattern shows that the thin films were highly textured along the c-axis and perpendicular to the surface of the substrate. Raman spectra reveal that Bi2O3 segregates mainly at ZnO-ZnO grain boundaries. After laser irradiation processing, the grain size of the film was reduced significantly, and the intrinsic atomic defects of grain boundaries and Bi element segregated at the grain boundary were interacted frequently and formed the composite defects of acceptor state. The nonlinear coefficient increased to 24.31 and the breakdown voltage reduced to 5.34 V.
- Published
- 2016
- Full Text
- View/download PDF
22. DESIGN AND SIMULATION ANALYSIS OF BRIDGE ANTI-COLLISION STRUCTURE BASED ON NONLINEAR NUMERICAL SIMULATION.
- Author
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RUIFANG CHEN and YANXIN ZHANG
- Subjects
MATERIAL plasticity ,COLLISIONS at sea ,NONLINEAR equations ,ENERGY conversion ,REFERENCE values ,BRIDGE foundations & piers ,BRIDGES - Abstract
In order to solve the dynamic nonlinear problem of bridge loads and responses during ship collisions, a design method for bridge anti-collision structures based on nonlinear numerical simulation was proposed. The author describes in detail the entire process of collision force evolution, energy conversion, and plastic deformation of the anti-collision energy dissipator, and conducts a comprehensive simulation of it. The experimental results show that when a ship with a mass of 1000 tons collides forward at speeds of 1, 3, and 5 meters per second, the collision depth is 0.23, 1.46, and 3.95 meters, respectively, less than the maximum allowable collision depth of 4.3 meters, and the collision energy dissipator is still in the protective working state for the bridge pier. When a ship with a mass of 3000 tons collides with the collision avoidance energy dissipator at a speed of 3 or 5 meters per second, the collision depth exceeds the maximum allowable collision depth, and the collision avoidance energy dissipator fails, the ship will directly collide with the wharf. The plastic deformation of the anti-collision energy dissipator provided has important reference value for design. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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23. Influence of Conjugacy Class Sizes of Some Elements on the Structure of a Finite Group
- Author
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Ruifang Chen and Xianhe Zhao
- Subjects
General Mathematics - Published
- 2023
24. Study on temporal and spatial changes of forest resources in Jiangsu Province in recent thirty years.
- Author
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Xiao Zhang, Gang Chen 0005, Ruifang Chen, Mengjiao Xue, Jing Yu, and Miaoran Duan
- Published
- 2015
- Full Text
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25. On Conjugacy Class Graph of Normal Subgroup
- Author
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Ruifang Chen and Xianhe Zhao
- Subjects
Algebra and Number Theory ,Applied Mathematics - Abstract
Let [Formula: see text] be a finite group and [Formula: see text] a normal subgroup of [Formula: see text]. Denote by [Formula: see text] the graph whose vertices are all distinct [Formula: see text]-conjugacy class sizes of non-central elements in [Formula: see text], and two vertices of [Formula: see text] are adjacent if and only if they are not coprime numbers. We prove that if the center [Formula: see text] and [Formula: see text]is [Formula: see text]-regular for [Formula: see text], then either a section of [Formula: see text]is a quasi-Frobenius group or [Formula: see text] is a complete graph with [Formula: see text] vertices.
- Published
- 2022
26. Effect of Metabolic Changes in Aphis gossypii-Damaged Cotton Plants on Oviposition Preference and Larval Development of Subsequent Helicoverpa armigera
- Author
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Shuaichao Zheng, Ruifang Chen, Lisha Wang, Shaodong Pan, Weijiao Liu, Xiangzhen Zhu, Xueke Gao, Junyu Luo, and Jinjie Cui
- Subjects
General Chemistry ,General Agricultural and Biological Sciences - Published
- 2022
27. Asian Horseshoe Crab Bycatch in Intertidal Zones of the Northern Beibu Gulf: Suggestions for Conservation Management
- Author
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Chun-Chieh Wang, Ruifang Chen, Xin Yang, Yulong Wen, Yang Kuang, Ce Zhang, Junhua Zhu, and Kit Yue Kwan
- Subjects
Ocean Engineering ,Oceanography - Published
- 2022
28. On weakly H-subgroups of finite groups II*
- Author
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Ruifang Chen, Xiaoli Li, and Xianhe Zhao
- Subjects
Algebra and Number Theory - Published
- 2022
29. Differential expression of immune-related genes between healthy volunteers and type 2 diabetic patients with spleen-deficiency pattern
- Author
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Longhui, Chen, Zemin, Yang, Weiwen, Chen, Ruliu, Li, Chuanquan, Lin, Lihua, Guan, Zhangzhi, Zhu, Ruifang, Chen, Saimei, Li, Lingbo, Zhao, Jinhao, Zeng, and Jianhua, Wang
- Published
- 2015
- Full Text
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30. Prediction of concrete compressive strength using a Deepforest-based model
- Author
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Wan Zhang, Jiangtao Guo, Cuiping Ning, Ruifang Cheng, and Ze Liu
- Subjects
Concrete ,Compressive strength ,Factor ,Machine learning ,Deepforest ,Medicine ,Science - Abstract
Abstract Concrete compressive strength testing is crucial for construction quality control. The traditional methods are both time-consuming and labor-intensive, while machine learning has been proven effective in predicting the compressive strength of concrete. However, current machine learning-based algorithms lack a thorough comparison among various models, and researchers have yet to identify the optimal predictor for concrete compressive strength. In this study, we developed 12 distinct machine learning-based regressors to conduct a thorough comparison and to identify the optimal model. To study the correlation between compressive strength and various factors, we conducted a comprehensive analysis and selected blast furnace slag, superplasticizer, age, cement, and water as the optimized factor subset. Based on this foundation, grid search and fivefold cross-validation were employed to establish the hyperparameters for each model. The results indicate that the Deepforest-based model demonstrates superior performance compared to the 12 models. For a more comprehensive evaluation of the model’s performance, we compared its performance with state-of-the-art models using the same independent testing dataset. The results demonstrate that our model achieving the highest performance (R2 of 0.91), indicating its accurate prediction capability for concrete compressive strength.
- Published
- 2024
- Full Text
- View/download PDF
31. Влияние размеров классов сопряженности некоторых элементов на структуру конечной группы
- Author
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Ruifang, Chen, primary, Хианьхэ, Чжао, additional, and Xianhe, Zhao, additional
- Published
- 2022
- Full Text
- View/download PDF
32. On the conjugate type vector and the structure of a normal subgroup
- Author
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Ruifang Chen and Lujun Guo
- Subjects
Normal subgroup ,Pure mathematics ,Vector (epidemiology) ,Structure (category theory) ,Type (model theory) ,Conjugate ,Mathematics - Published
- 2021
33. Bevacizumab confers significant improvements in survival for ovarian cancer patients with low miR-25 expression and high miR-142 expression
- Author
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Ruifang Chen, Guohua Zhu, Xin Lu, Tingting Zhu, Huiran Yue, Jun Li, and Wenzhi Li
- Subjects
Oncology ,medicine.medical_specialty ,Bevacizumab ,Lymphovascular space invasion ,Antineoplastic Agents, Immunological ,Ovarian cancer ,Statistical significance ,Internal medicine ,microRNA ,Medicine ,Humans ,In patient ,Progression-free survival ,Ovarian Neoplasms ,business.industry ,Research ,Obstetrics and Gynecology ,MicroRNA ,Gynecology and obstetrics ,Nomogram ,Debulking ,medicine.disease ,Prognosis ,Progression-Free Survival ,Gene Expression Regulation, Neoplastic ,Survival Rate ,MicroRNAs ,Nomograms ,Treatment Outcome ,Lymphatic Metastasis ,RG1-991 ,Female ,business ,medicine.drug - Abstract
Background Lymphovascular space invasion (LVSI) is the first step of hematogenous metastasis. Exploration of the differential miRNA expression profiles between LVSI-positive and LVSI-negative ovarian cancer tissues may help to identify key miRNAs involved in the hematogenous metastasis of ovarian cancer. This study is aimed to identify microRNAs (miRNAs) that are differentially expressed between LVSI-positive and LVSI-negative ovarian cancer tissues, followed by exploring their association with bevacizumab response in ovarian cancer patients. Methods The Cancer Genome Altas (TGGA) dataset was used to identify the differentially expressed miRNAs between LVSI-positive and LVSI-negative ovarian cancer tissues. The prognostic value of the differentially expressed miRNAs was determined using GSE140082 dataset. Results We showed that miR-25 and miR-142 were differentially expressed between LVSI-positive and LVSI-negative ovarian cancer tumors. Kaplan-Meier analysis indicated that high miR-25 expression was associated with increased progression free survival (PFS) and extended overall survival (OS). Moreover, patients with low miR-25 expression benefited significantly from bevacizumab treatment in terms of PFS. A similar trend was observed in terms of OS though without reaching statistical significance. In contrast, no significant survival benefits from bevacizumab were observed in patients with high miR-25 expression in terms of PFS and OS. There was no significant correlation between miR-142 expression and PFS. In contrast, high miR-142 expression was associated with reduced OS. Moreover, patients with high miR-142 expression benefited significantly from bevacizumab treatment in terms of PFS and OS. However, bevacizumab treatment conferred no significant improvements in both PFS and OS in patients with low miR-142 expression. The nomogram for PFS indicated that miR-25 expression had a larger contribution to PFS than debulking status and bevacizumab treatment. And the nomogram for OS illustrated both miR-25 expression and miR-142 expression as sharing a larger contribution to OS than bevacizumab treatment and debulking status. Conclusion In conclusion, miR-25 expression correlates with a better PFS and OS in ovarian cancer. Patients with low miR-25 expression and high miR-142 expression could benefit from bevacizumab treatment significantly.
- Published
- 2021
34. Residual Compressive Strength of Aluminum Honeycomb Sandwich Structures with CFRP Face Sheets after Low-velocity Impact
- Author
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Jun Wang, Chen Wang, Ruifang Chen, and Chao Zhang
- Subjects
Ceramics and Composites - Published
- 2022
35. On weakly ℋ-subgroups of finite groups III
- Author
-
Ruifang Chen and Xianhe Zhao
- Subjects
Algebra and Number Theory ,Applied Mathematics - Abstract
Let [Formula: see text] be a group. A subgroup [Formula: see text] of [Formula: see text] is called an [Formula: see text]-subgroup in [Formula: see text] if [Formula: see text] for all [Formula: see text]. Furthermore, a subgroup [Formula: see text] of [Formula: see text] is called a weakly [Formula: see text]-subgroup in [Formula: see text] if there exists a normal subgroup [Formula: see text] of [Formula: see text] such that [Formula: see text] and [Formula: see text] is an [Formula: see text]-subgroup in [Formula: see text]. In this paper, some new criteria for a group to be [Formula: see text]-nilpotent and supersolvable are given.
- Published
- 2022
36. An Improved Algorithm of Double-layered Dynamic Matrix Predictive Control
- Author
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Benji Su, Ruifang Chen, Wenqin Jiang, Yulong Zeng, Xu Yao, and Xiang Li
- Published
- 2022
37. Effect of Interrupted Aging–Retrogression Re-Aging Treatment on the Microstructure and Properties of Al-Zn-Mg-Cu Alloy
- Author
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Tao Wei, Ruifang Chen, Xiaojing Xu, Hongbo Wei, Guoning Bao, and Lele Liu
- Subjects
Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2022
38. On $\mathcal{M}$-normal embedded subgroups and the structure of finite groups
- Author
-
Rui Li, Xianhe Zhao, and Ruifang Chen
- Subjects
Pure mathematics ,General Mathematics ,Structure (category theory) ,Mathematics - Abstract
Let $G$ be a group and $H$ be a subgroup of $G$. $H$ is said to be $\mathcal{M}$-normal supplemented in $G$ if there exists a normal subgroup $K$ of $G$ such that $G=HK$ and $H_1K
- Published
- 2021
39. Clinicopathological Characteristics and Prognosis of 91 Patients with Seromucinous and Mucinous Borderline Ovarian Tumors: a Comparative Study
- Author
-
Beibei Wu, Jun Li, Xiang Tao, Jieyu Wang, Guohua Zhu, Xin Lu, and Ruifang Chen
- Subjects
Obstetrics and Gynecology - Abstract
To explore the differences in clinicopathological characteristics and prognosis between seromucinous borderline ovarian tumors (SMBOTs) and mucinous borderline ovarian tumors (MBOTs). Ninety-one patients with SMBOTs and MBOTs who underwent surgery at the Obstetrics and Gynecology Hospital of Fudan University from July 2006 to January 2015 were included. The median onset age of patients with SMBOTs (29 years, 20-77) was younger than that of patients with MBOTs (37 years, 16-71). SMBOTs were more likely to be exogenous and show bilateral ovarian involvement and had a smaller average tumor size of 10.63 cm, while MBOTs were more prone to endogenous growth and show unilateral involvement and had a larger average tumor size of 18.55 cm (p 0.05). Compared with MBOTs, SMBOTs were characterized by the expression of Mullerian differentiation markers (p 0.05). Recurrence occurred in 15.8% patients with SMBOT and 9.1% patients with MBOT. One case of SMBOT (2.6%) and one case of MBOT (2.3%) progressed to malignancy during follow-up, but no disease-related death was observed. Age less than 40 years was a risk factor for recurrence, while the effect of fertility-sparing surgery (FSS) on recurrence requires a larger sample size to be validated. The clinical characteristics of SMBOTs and MBOTs are similar but also quite different. High expression of Mullerian differentiation markers in SMBOT may indicate a better response to hormone therapy. Repeated FSS should be performed with caution and fully informed because of the risk of recurrence and progression to malignancy.
- Published
- 2022
40. Efficacy and transcriptome analysis of golden pompano (Trachinotus ovatus) immunized with a formalin-inactived vaccine against Streptococcus iniae
- Author
-
Xiangying Xiong, Yinhui Peng, Ruifang Chen, Xujia Liu, and Fajun Jiang
- Subjects
Environmental Chemistry ,General Medicine ,Aquatic Science - Abstract
Streptococcus iniae is a worldwide fish pathogen that cause tremendous economic losses to the global aquaculture industry. Vaccination is regarded as the most effective and safe way to control fish diseases. In our study, we developed a formalin-inactivated vaccine against S. iniae and evaluated its effect in golden pompano (Trachinotus ovatus). In addition, in order to clarify the molecular mechanisms underlying the vaccine protection, we compared the spleen transcriptomes of vaccinated and unvaccinated golden pompano at 1, 2 and 7 d post vaccination using the RNA-seq technology. The relative percentage survival (RPS) reached 71.1% at 28 days post-vaccination which suggested that the vaccine provided highly protection against S. iniae. KEGG pathway analysis revealed that phagosome, cytokine-cytokine receptor interaction, MAPK signaling pathway, and CAMs were activated by the vaccine. The most of strongly up-regulated genes in golden pompano spleen are involving in innate immunity. For adaptive immunity, the vaccine evoked a CD8
- Published
- 2022
41. High-capacity and superior behavior of the Ni–Cu co-doped spinel LiMn2O4 cathodes rapidly prepared via microwave-induced solution flameless combustion
- Author
-
Xiaofang Liu, Ruifang Chen, Zhaoyao Sa, Hong Li, Mingwu Xiang, Wei Bai, Changwei Su, and Junming Guo
- Subjects
Chemistry ,Spinel ,Analytical chemistry ,High capacity ,General Chemistry ,Crystal structure ,engineering.material ,Combustion ,Catalysis ,Cathode ,law.invention ,law ,Structural stability ,Electrode ,Materials Chemistry ,engineering ,Microwave - Abstract
A simple and rapid microwave-induced solution flameless combustion method to prepare high-capacity Ni–Cu co-doped spinel LiMn2O4 is provided in this work. Ni–Cu co-doping effectively reduces the lattice parameters and Jahn–Teller effect of the spinel LiMn2O4 to obtain a more stable crystal structure. The microscopic morphological characteristics clarify that the growth and development of grains is significantly controlled by microwave treatment and Ni–Cu co-doping. The optimized LMNCO-0.050 electrode exhibits a higher initial discharge capacity of 128.1 mA h g−1 than the un-doped LMO electrode of 120.6 mA h g−1 at 1 C and room temperature. In particular, the LMNCO-0.050 electrode achieves high initial discharge specific capacities of 111.3 and 106.8 mA h g−1 at high rates of 5 C and 10 C, corresponding to excellent retention rates of 70.89% and 77.43% after 1000 cycles. Moreover, the excellent retention of 41.89% of the LMNCO-0.050 electrode after 1000 ultra-long cycles at 55 °C and 1 C can be attributed to the improved structural stability of the LiMn2O4 by Ni–Cu co-doping.
- Published
- 2021
42. On the p -regular G-conjugacy classes with sizes 1 or minimal
- Author
-
Ruifang Chen, Qin Huang, Yanyan Zhou, and Xianhe Zhao
- Subjects
Combinatorics ,Hall subgroup ,Normal subgroup ,Finite group ,Mathematics (miscellaneous) ,Conjugacy class ,Element (category theory) ,Mathematics - Abstract
Let N be a p-solvable normal subgroup of a finite group G, and Np′ be a p′ -Hall subgroup of N . If x is an element of G, then the conjugacy class size |xG| = |G : CG(x)|. Obviously, when CG(x) is ...
- Published
- 2020
43. Significant Improvement of LiMn2O4 Cathode Capacity by Introducing Trace Ni During Rapid Microwave-induced Solution Combustion
- Author
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Wei Bai, Junming Guo, Bixia Wen, Changwei Su, and Ruifang Chen
- Subjects
Trace (semiology) ,Materials science ,law ,Electrochemistry ,Analytical chemistry ,Solution combustion ,Microwave ,Lithium-ion battery ,Cathode ,law.invention - Published
- 2020
44. The individualized significance of lymphadenectomy across all age groups and histologies in malignant ovarian germ cell tumors
- Author
-
Ruifang Chen, Jun Li, Jieyu Wang, and Xin Lu
- Subjects
Adult ,Oncology ,China ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Cohort Studies ,03 medical and health sciences ,Age Distribution ,0302 clinical medicine ,Internal medicine ,Malignant Ovarian Germ Cell Tumor ,Dysgerminoma ,Humans ,Medicine ,Child ,Lymph node ,Survival analysis ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Ovarian Neoplasms ,030219 obstetrics & reproductive medicine ,business.industry ,Infant, Newborn ,Teratoma ,Infant ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,Neoplasms, Germ Cell and Embryonal ,Prognosis ,medicine.disease ,medicine.anatomical_structure ,Child, Preschool ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Lymph Node Excision ,Female ,Lymphadenectomy ,Lymph Nodes ,Lymph ,Germ cell tumors ,business - Abstract
To evaluate the therapeutic role of lymphadenectomy on patients with malignant ovarian germ cell tumor (MOGCT) and to investigate the risk factors of lymph node metastasis. Patients of MOGCT between 1988 and 2013 with definite lymph node information were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Survival curves were estimated using the Kaplan–Meier method, and Cox regression analyses were performed to evaluate the effects of clinical and pathologic variables on survival. 2424 MOGCT patients with information on lymph nodes were included. Of the entire cohort, 46.2% patients received lymphadenectomy. The most common (42.2%) histologic type was teratoma, and 70.6% patients had FIGO stage I disease. Cox proportional model verified that age, grade, and log odds of positive lymph nodes (LODDS) were independent prognostic factors. Subgroup analysis showed that the association between the lymph node resection and better survival in the different age cohort. Lymphadenectomy is not recommended for children (0–14 years). For patients 40 years of age and older, and for those who have the dysgerminoma type or endodermal sinus type, lymphadenectomy had an outstanding therapeutic role. As a parameter to assess lymph node status, LODDS could be used to classify MOGCTs.
- Published
- 2020
45. Sirtuin 7 promotes non‑small cell lung cancer progression by facilitating G1/S phase and epithelial‑mesenchymal transition and activating AKT and ERK1/2 signaling
- Author
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Xia Ye, Min Tao, Ruifang Chen, Daguo Zhao, Chunhua Ling, Yingying Zhao, Yulan Qian, Yufeng Xie, Qian Gao, and Chun Xu
- Subjects
Male ,0301 basic medicine ,Cancer Research ,Lung Neoplasms ,Mice ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,sirtuin 7 ,Sirtuins ,Pneumonectomy ,Lung ,Aged, 80 and over ,Mitogen-Activated Protein Kinase 1 ,Mitogen-Activated Protein Kinase 3 ,Articles ,General Medicine ,Middle Aged ,Cell cycle ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,Oncology ,Gene Knockdown Techniques ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,cell cycle ,Adult ,extracellular signal-regulated kinase 1/2 ,Epithelial-Mesenchymal Transition ,MAP Kinase Signaling System ,Down-Regulation ,Biology ,03 medical and health sciences ,Cyclin-dependent kinase ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Epithelial–mesenchymal transition ,Lung cancer ,Protein kinase B ,non-small cell lung cancer ,Aged ,Cell Proliferation ,Cell growth ,Gene Expression Profiling ,Cyclin-dependent kinase 2 ,Cancer ,medicine.disease ,G1 Phase Cell Cycle Checkpoints ,Xenograft Model Antitumor Assays ,respiratory tract diseases ,030104 developmental biology ,Cancer research ,biology.protein ,protein kinase B ,Proto-Oncogene Proteins c-akt - Abstract
Increasing evidence has indicated the roles of sirtuin 7 (SIRT7) in numerous human cancers. However, the effects and the clinical significance of SIRT7 in human lung cancer is largely unknown. The present research demonstrated that SIRT7 was increased in human lung cancer tumor tissues. SIRT7 upregulation was associated with clinicopathological characteristics of lung cancer malignancy including positive lymph node metastasis, high pathologic stage and large tumor size. SIRT7 was also upregulated in human non-small cell lung cancer (NSCLC) cell lines. Furthermore SIRT7-overexpressed A549 (A549-SIRT7) and SIRT7-knocked down H292 (H292-shSIRT7) human NSCLC cell lines were established. Using these NSCLC cells and xenograft mouse models, it was revealed that SIRT7 overexpression markedly promoted growth and G1 to S cell cycle phase transition as well as migration, invasion and distant lung metastasis in A549 NSCLC cells, whereas SIRT7 knockdown suppressed these processes in H292 NSCLC cells. Mechanistically, in A549 NSCLC cells, SIRT7 overexpression significantly activated not only protein kinase B (AKT) signaling but also extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. SIRT7 overexpression also significantly downregulated cyclin-dependent kinase (CDK) inhibitors including p21 and p27 as well as upregulated cyclins including cyclin D1 and cyclin E1, and CDKs including CDK2 and CDK4. Notably, the epithelial-mesenchymal transition (EMT) process of A549 NSCLC cells was facilitated by SIRT7 overexpression, as evidenced by E-cadherin epithelial marker downregulation and mesenchymal markers (N-cadherin, vimentin, Snail and Slug) upregulation. In addition, SIRT7 knockdown in H292 NSCLC cells exhibited the opposite regulatory effects. Moreover, inhibition of AKT signaling abated the promoting effects of SIRT7 in NSCLC cell proliferation and EMT progression. The present data indicated that SIRT7 accelerated human NSCLC cell growth and metastasis possibly by promotion of G1 to S-phase transition and EMT through modulation of the expression of G1-phase checkpoint molecules and EMT markers as well as activation of AKT and ERK1/2 signaling. SIRT7 could be an innovative potential target for human NSCLC therapy.
- Published
- 2020
46. Primary subgroups and the structure of finite groups
- Author
-
Ruifang Chen, Xianhe Zhao, and Rui Li
- Subjects
Crystallography ,Algebra and Number Theory ,Group (mathematics) ,010102 general mathematics ,Structure (category theory) ,010103 numerical & computational mathematics ,0101 mathematics ,01 natural sciences ,Abnormal subgroup ,Mathematics - Abstract
Let G be a group and H≤G. The permutizer of H in G is PG(H)=〈x|x∈G,〈x〉H=H〈x〉〉. H is said to be strongly permuteral in G if PU(H)=U whenever H≤U≤G. Moreover, let PGP(H)=〈x|x is a primary element of ...
- Published
- 2020
47. On the centralizers of the p-regular elements in a finite group
- Author
-
Yanyan Zhou, Xianhe Zhao, Qin Huang, and Ruifang Chen
- Subjects
Hall subgroup ,Physics ,Combinatorics ,Finite group ,General Mathematics ,Structure (category theory) ,Element (category theory) ,Prime (order theory) - Abstract
Let G be a p-solvable finite group for some prime p, $$G_{p'}$$ a $$p'$$ -Hall subgroup of G and x a p-regular element of G. Clearly, $$\langle x\rangle \le C_G(x)\le G$$ . Notice that the structure of $$G_{p'}$$ is easily decided when $$C_G(x)=\langle x\rangle $$ and $$C_G(x)=G$$ for every p-regular element x of G. So, in this paper, we investigate the structure of $$G_{p'}$$ by assuming that $$C_G(x)$$ is maximal in G for every non-central p-regular element x of G.
- Published
- 2020
48. Groups in which the centralizer of any non-central element is maximal
- Author
-
Ruifang Chen, Xianhe Zhao, and Xiuyun Guo
- Subjects
Pure mathematics ,Algebra and Number Theory ,010102 general mathematics ,0103 physical sciences ,010307 mathematical physics ,0101 mathematics ,01 natural sciences ,Central element ,Centralizer and normalizer ,Mathematics - Abstract
Let x be an element of a finite group G. It is clear that 〈 x 〉 ≤ C G ( x ) ≤ G {\langle x\rangle\leq C_{G}(x)\leq G} . For the cases where C G ( x ) = G {C_{G}(x)=G} and C G ( x ) = 〈 x 〉 {C_{G}(x)=\langle x\rangle} for any element x of G, the structure of G is easily decided. In this paper, we investigate the case where C G ( x ) {C_{G}(x)} is maximal in G and obtain the structure of G.
- Published
- 2020
49. The sub-class sizes of some elements being square free
- Author
-
Xianhe Zhao, Yanyan Zhou, Ruifang Chen, and Qin Huang
- Subjects
TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES ,Algebra and Number Theory ,Computer Science::Information Retrieval ,Applied Mathematics ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Astrophysics::Instrumentation and Methods for Astrophysics ,Computer Science::General Literature ,Computer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing) ,ComputingMilieux_MISCELLANEOUS - Abstract
Let x be an element of a finite group G, and p a prime factor of the order of G. It is clear that there always exists a unique minimal subnormal subgroup containing x, say [Formula: see text]. We call the conjugacy class of x in [Formula: see text] the sub-class of x in G, see [G. Qian and Y. Yang, On sub-class sizes of finite groups, J. Aust. Math. Soc. (2020) 402–411]. In this paper, assume that [Formula: see text] is the product of the subgroups A and B, we investigate the solvability, p-nilpotence and supersolvability of the group G under the condition that the sub-class sizes of prime power order elements in [Formula: see text] are [Formula: see text] free, [Formula: see text] free and square free, respectively, so that some known results relevant to conjugacy class sizes are generalized.
- Published
- 2021
50. On the Normal Subgroup with Minimal G-Conjugacy Class Sizes
- Author
-
Ruifang Chen, Hongliang Zuo, Yanyan Zhou, Qin Huang, and Xianhe Zhao
- Subjects
Combinatorics ,Normal subgroup ,Finite group ,Maximal subgroup ,Conjugacy class ,General Mathematics ,Structure (category theory) ,Element (category theory) ,Mathematics - Abstract
Let N be a normal subgroup of a finite group G, and x an element of N. Objective that $$|x^G|=|G:C_G(x)|$$ , so $$|x^G|$$ is called “minimal” when $$C_G(x)$$ is a maximal subgroup of G. In this paper, we characterize the structure of N when $$|x^G|$$ is minimal for every non-G-central element x of N.
- Published
- 2021
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