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Bridged aminoperoxides, for the first time, were investigated for the in vitro antimalarial activity against the chloroquine-resistant Plasmodium falciparum strain K1 and for their cytotoxic activities against immortalized human normal liver (LO2) and lung (BEAS-2B) cell lines as well as human liver (HepG2) and lung (A549) cancer cell lines. Aminoperoxides exhibit good cytotoxicity against lung A549 cancer cell line. Synthetic ozonides were shown to have high activity against the chloroquine-resistant P. falciparum. A cyclic voltammetry study of peroxides was performed, and most of the compounds did not show a direct correlation in oxidative capacity-activity. Peroxides were analyzed for ROS production to understand their mechanism of action. However, none of the compounds has an impact on ROS generation, suggesting that ozonides induce apoptosis in HepG2 cells through ROS-independent dysfunction pathway.

Graphical abstract Schematic diagram of the complications, possible treatments, and potential resistant target genes of IVIG resistant KD patient., Kawasaki disease is an acute childhood self-limited vasculitis, causing the swelling or inflammation of medium-sized arteries, eventually leading to cardiovascular problems such as coronary artery aneurysms. Acetylsalicylic acid combined with intravenous immunoglobulin (IVIG) is the standard treatment of Kawasaki disease (KD). However, a rising number of IVIG resistant cases were reported with severe disease complications such as the KD Shock Syndrome or KD-Macrophage activation syndrome. Recent reports have depicted the overlapped number of children with SARS-CoV-2 and KD, which was called multisystem inflammatory syndrome. Simultaneously, the incidence rate of KD-like diseases are increased after the outbreak of COVID-19, suggesting the virus may be associated with KD. New intervention is important to overcome the problem of IVIG treatment resistance. This review aims to introduce the current pharmacological intervention and possible resistance genes for the discovery of new drug for IVIG resistant KD.

With the increase in human lifespan, population aging is one of the major problems worldwide. Aging is an irreversible progressive process that affects humans via multiple factors including genetic, immunity, cellular oxidation and inflammation. Progressive neuroinflammation contributes to aging, cognitive malfunction, and neurodegenerative diseases. However, precise mechanisms or drugs targeting age-related neuroinflammation and cognitive impairment remain un-elucidated. Traditional herbal plants have been prescribed in many Asian countries for anti-aging and the modulation of aging-related symptoms. In general, herbal plants' efficacy is attributed to their safety and polypharmacological potency via the systemic manipulation of the body system. Radix polygalae (RP) is a herbal plant prescribed for anti-aging and the relief of age-related symptoms; however, its active components and biological functions remained un-elucidated. In this study, an active methanol fraction of RP containing 17 RP saponins (RPS), was identified. RPS attenuates the elevated C3 complement protein in aged mice to a level comparable to the young control mice. The active RPS also restates the aging gut microbiota by enhancing beneficial bacteria and suppressing harmful bacteria. In addition, RPS treatment improve spatial reference memory in aged mice, with the attenuation of multiple molecular markers related to neuroinflammation and aging. Finally, the RPS improves the behavior and extends the lifespan of C. elegans, confirming the herbal plant's anti-aging ability. In conclusion, through the mouse and C. elegas models, we have identified the beneficial RPS that can modulate the aging process, gut microbiota diversity and rectify several aging-related phenotypes.

Lijiang 2.4-meter Telescope(LJT), the largest common-purpose optical telescope in China, has been applied to the world-wide astronomers since 2008. It is located at Gaomeigu site, Lijiang Observatory(LJO), the southwest of China. The site has very good observational conditions. Since 10-year operation, several instruments have been equipped on the LJT. Astronomers can perform both photometric and spectral observations. The main scientific goals of LJT include photometric and spectral evolution of supernova, reverberation mapping of active galactic nucleus, physical properties of binary star and near-earth object(comet and asteroid), identification of exoplanet, and all kinds of transients. Until now, the masses of 41 high accretion rate black holes have been measured, and more than 168 supernova have been identified by the LJT. More than 190 papers related to the LJT have been published. In this paper, the general observation condition of the Gaomeigu site is introduced at first. Then, the LJT structure is described in detail, including the optical, mechanical, motion and control system. The specification of all the instruments, and some detailed parameters of the YFOSC is also presented. Finally, some important scientific results and future expectations are summarized., Comment: 20 pages, 14 figures, accepted by Research in Astronomy and Astrophysics(RAA)

As a facility used for astronomical research, the Lijiang 2.4-m telescope of Yunnan Astronomical Observatories, requires the ability to change one auxiliary instrument with another in as short a time as possible. This arises from the need to quickly respond to scientific programs (e.g. transient observation, time domain studies) and changes in observation conditions (e.g. seeing and weather conditions). In this paper, we describe the design, construction and test of hardware and software in the rapid instrument exchange system (RIES) for the Cassegrain focal station of this telescope, which enables instruments to be quickly changed at night without much loss of observing time. Tests in the laboratory and at the telescope show that the image quality and pointing accuracy of RIES are satisfactory. With RIES, we observed the same Landolt standard stars almost at the same time with the Princeton Instruments VersArray 1300B Camera (PICCD) and the Yunnan Faint Object Spectrograph and Camera (YFOSC), while both were mounted at the Cassegrain focus. A quasi-simultaneous comparison shows that the image quality of the optical system inside the YFOSC is comparable with that provided by the PICCD.

The centrosymmetric title molecule, C28H32N2O2, has a central benzene ring subsituted in the 1- and 4-positions by (ethene-2,1-diyl)pyridine groups, and in the 2- and 5-positions by butoxy groups. The whole molecule is X-shaped and relatively flat, the dihedral angle between the pyridine and the central benzene ring being 11.29 (10)°. In the crystal, neighboring molecules are linked by weak C—H...N interactions, forming a two-dimensional undulating network.

Crystals of the title compound, [Co(C8H4O5)(H2O)3] n , were obtained by hydrothermal methods. Each CoII ion is six-coordinated by two O atoms from one 5-hydroxybenzene-1,3-dicarboxylate (L) ligand, one O atom from another L ligand and three water molecules [Co—O = 2.016 (3)–2.324 (3) Å]. Each ligand L, acting in a tridentate mode, bridges two Co ions, resulting in the formation of polymeric zigzag chains extending along the [110] direction. The crystal packing is stabilized by an extensive network of O—H...O hydrogen bonds.