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Introduction Compensatory sweating (CS) is a common complication after thoracoscopic sympathectomy (TS) and is mainly associated with surgical technique. Our aim was to identify potential risk-factors for CS following TS for primary focal hyperhidrosis in children. Methods A retrospective, single-center review of all bilateral TS was performed between 2017 and 2019. Hyperhidrosis disease severity scale was used for pre-operative severity assessment. Post-operative evaluations were performed after three and six months. Results More than the 36-month period, 41 patients were submitted to T2–T4 TS, and 25 were females (60.9%). Median age at surgery was 15.5 years. CS was identified at the 3rd month in 17 (41%) children with most in the dorsolumbar region (56%). By the 6th month, there was a significant reduction in CS (41 to 32%, p = 0.02). The probability of resolution of CS by 6 months is about 50% in both the dorsolumbar and abdominal regions. Neither age, gender, body mass index, family history, or concomitant illnesses seemed to influence CS (p > 0.05). Axillary hyperhidrosis appears to be associated with the development of dorsolumbar CS (p = 0.037). Conclusion Thoracoscopic sympathectomy for PFH is a safe and effective procedure, but compensatory sweating can be a common and debilitating side effect. Age, gender, and body mass index do not appear to influence CS. Axillary hyperhidrosis may be related to the development of dorsolumbar CS. Level of evidence III.

The evaluation of the competence of personnel working with laboratory animals is currently a challenge. Directive 2010/63/EU establishes that staff must have demonstrated competence before they perform unsupervised work with living animals. Nevertheless, there is a lack of research into education and training in laboratory animal science, and the establishment of assessment strategies to confirm researchers’ competence remains largely unaddressed. In this study, we analysed the implementation of a practical assessment strategy over three consecutive years (2018–2021) using the Objective Structured Laboratory Animal Science Exam (OSLASE) developed previously by us to assess professional competence. The interrater reliability (IRR) was determined based on the assessors’ rating of candidates’ performance at different OSLASE stations using weighted kappa (Kw) and percentage of agreement. Focus group interviews were conducted to access trainees’ acceptability regarding the OSLASE. There was a moderate-to-good Kw for the majority of the scales’ items (0.79 ± 0.20 ≤ Kw ≥ 0.45 ± 0.13). The percentages of agreement were also acceptable (≥75%) for all scale items but one. Trainees reported that the OSLASE had a positive impact on their engagement during practical training, and that it clarified the standards established for their performance and the skills that required improvement. These preliminary results illustrate how assessment strategies, such as the OSLASE, can be implemented in a manner that is useful for both assessors and trainees. Examen structuré objectif de science animale de laboratoire (OSASSE) pour assurer la compétence professionnelle des chercheurs en SAL

Mediastinal teratomas presenting in the pediatric age are extremely rare. We report three cases of mediastinal teratomas in children aged 15 months to 9 years. Patients were submitted to complete tumor resection, with an uneventful postoperative course and follow-up. Our report emphasizes the importance of a detailed patient examination and careful interpretation of routinely performed image studies., Portuguese Journal of Cardiac Thoracic and Vascular Surgery, Vol. 29 No. 3 (2022): Jul - Sep

The ideal approach to hemodynamically unstable patients requires the quick identification of the type of shock and its etiology. This can be a challenge in critically ill patients due to the limited information, the wide number of differential diagnosis and the need for fast intervention. Point-of-care ultrasound (POCUS) is a non-invasive, low-cost, real-time and reliable tool used to rapidly and accurately assess hemodynamically unstable patients at the bedside. It can support diagnosis, tailor therapy and guide further workup, especially in patients deemed too unstable to undergo other imaging studies. The authors describe the case of a patient in obstructive shock due to pulmonary embolism, in which McConnell sign was identified by bedside echocardiography, before lab tests and pulmonary computerized tomography angiogram results were obtained.

Burns are a common cause of pediatric injury and represent significant morbidity and mortality in this age group. In children, most burns are thermal, resulting from exposure to a hot surface, liquid, or fire. Cyanoacrylate is a liquid compound commonly found in households, mainly in “superglue” and nail glue. This compound solidifies through an exothermic reaction that is magnified when in contact with certain fibers that act as catalysts, such as cotton. In these circumstances, intense heat is produced in the contact area, potentially causing severe thermal burns. Despite its widespread availability, there is a paucity of safety information about cyanoacrylate and its role as a cause for burns. In the literature, only 18 cases of cyanoacrylate burns are reported in children. We present two cases of pediatric burns with cyanoacrylate and a review of the literature.

Non-islet cell tumor hypoglycemia is a rare paraneoplastic condition caused by an extra-pancreatic tumor. We report a rare case of hypoglycemia caused by a relapsing pelvic solitary fibrous tumor associated with Big-IGF-2 production. A 72-year-old woman was admitted to our hospital because of loss of consciousness and hypoglycemia. She had a history of ovarian solitary fibrous tumor, which has relapsed. From investigation, serum levels of insulin and C-peptide were suppressed; IGF-1 was slightly reduced and IGF-2 was within the normal range, but the IGF-2: IGF-1 ratio was elevated, indicating the presence of Big-IGF-2 secreting non-islet cell tumor. Contrast-enhanced computed tomography (CT) showed a large pelvic mass. She was then submitted to surgical resection of the mass, which histologically proved to be a solitary fibrous tumor. Three months later, she remains asymptomatic. Non-islet cell tumor hypoglycemia should be considered in the differential diagnosis of patients presenting with tumors and recurrent hypoglycemia.

Mestrado em Finanças Equity Research sobre a Ryanair Holdings PLC (RYA), elaborado segundo as recomendações do CFA Institute, que integra a avaliação minuciosa de toda a sua atividade, com o objetivo final de se perspetivar o valor intrínseco das suas ações a 31 de Dezembro de 2020. A estrutura orgânica do presente documento é dividida em duas partes distintas: uma primeira parte, onde se analisa e se apresenta a RYA e a indústria onde se insere e uma segunda parte, onde, considerando as informações da primeira parte, se projeta e se mensura o desenvolvimento da empresa nos próximos anos, recorrendo a modelos de avaliação como o dos Fluxos de Caixa Atualizados e o Valor Atual Ajustado (métodos absolutos) e ainda ao modelo dos Múltiplos comparáveis (método relativo). Todo o conteúdo deste projeto contempla informações passíveis de análise até dia 27 de Setembro de 2019. Com um preço-alvo de €10,95, no final de 2020, calculado através do modelo dos Fluxos de Caixa Atualizados, representando um potencial de valorização de 6,37% considerando o preço de €10,29, a 27 de Setembro de 2019, a nossa recomendação de investimento é MANTER, ou seja, não se considera a existência de razões fortes para a compra, nem de razões negativas para a venda. Seguindo as especificações do modelo de Valor Atual Ajustado, alcança-se um resultado idêntico que sustenta a mesma recomendação. Com um preço-alvo de €11,10, o que totaliza um potencial de valorização de 7,90%, o conselho de MANTER, preserva-se. As part of the Master's Final Work in Finance, and according to the recommendations of the CFA Institute, this project about Ryanair Holdings PLC (RYA), which integrates the scrupulous analysis of all its business activity, has been settled with the main purpose of knowing the intrinsic value of its shares, on the 31st December, 2020. The organic structure of this project is divided into two distinct parts. The first part where RYA is analyzed and also the industry in which the Company operates; the second part, in which, the information in the first part is considered and it is forecasted and measured the Company's growth, over the next few years, using valuation models as Discounted Cash Flows (DCF), Adjusted Present Value (absolute methods) and the Multiples Approach (relative method). All of the developments of this project include information until 27th September 2019. With a target price of €10.95 at the end of 2020, given the DCF Model, representing an upside potential of 6.37% over the price of €10.29, on 27th September 2019, our investment recommendation is HOLD, that is no strong reasons for buying or selling. Considering the main features of Adjusted Present Value Model, an identical result was reached that supports the same investment recommendation. With a target price of €11.10, which adds up to a 7.90% upside potential, the advice of HOLD is well-maintained. info:eu-repo/semantics/publishedVersion

Background: Acupuncture is still a controversial topic, as methodologic problems associated to its research impair scientific progress. Besides effective allocation of acupoints and double blinding, quantification of its effects is still a problem that has to be addressed. In particular, the effects of acupuncture need to be quantified more clearly for relieving pain and reducing inflammatory effects associated to Rheumatoid Arthritis (RA). We aim to study the effects of acupuncture resorting to an algometry device specifically designed to assess the pressure tolerated by RA patients. Methods/Design: A quasi-experimental nature design was developed. Fourteen RA patients with a Traditional Chinese Medicine (TCM) (Heidelberg Model) diagnosis of a so called pivotal or turning point syndrome, and meeting the criteria of the American College of Rheumatology, received three acupuncture treatments in one week with a standardized treatment. A newly developed pressure algometry device, designed to assess the tolerance in hand pain in RA, was tested. We compared the outcome of clinical acupuncture, as measured by Pressure Algometry (PA) and Visual Analogue Scale (VAS). Results: The patients tolerated higher pressure on the hands (p=0.001) as well as improved VAS scores along with the treatment (p=0.005). All 14 patients displayed improvements in PA, while 11 improved their VAS scores. Out of the remaining, two patients had their VAS score unaltered and one (who also displayed the smallest improvement in PA) worsened slightly. Discussion: The findings of this study suggest that acupuncture effects in hand pain relief can be measured by the PA device. This opens the door to quantify the differences between the tolerated hand pressure before and after the acupuncture treatment to one specific TCM syndrome designed as turning point in a future double blinded acupuncture study on pain in RA patients. Trial Registration Number: NCT02553005.

Tese de mestrado, Segurança Informática, Universidade de Lisboa, Faculdade de Ciências, 2019 Submitted by Teresa Boa (tdboa@fc.ul.pt) on 2019-02-27T10:36:45Z No. of bitstreams: 1 ulfc124841_tm_Rui_Azevedo.pdf: 24173173 bytes, checksum: 42c0cf406a110c6c4363b45b78789709 (MD5) Made available in DSpace on 2019-02-27T10:36:54Z (GMT). No. of bitstreams: 1 ulfc124841_tm_Rui_Azevedo.pdf: 24173173 bytes, checksum: 42c0cf406a110c6c4363b45b78789709 (MD5) Previous issue date: 2019

Predatory arthropods are commonly used as biological control agents (BCAs). They are released in commercial vegetable greenhouses as primary elements of integrated pest management programmes for some of the most devastating pests on pepper and tomato in southeastern Spain. Emamectin benzoate, a macro-cyclic lactone insecticide derived from the avermectin family of natural products, is being developed for the control of Lepidoptera pests on a variety of crops in Europe including vegetables. The compatibility of emamectin benzoate with the predatory BCAs Amblyseius swirskii Athias-Henriot and Orius laevigatus (Fieber) in field trials (direct spray and aged residues) and Macrolophus pygmaeus (Rambur) and Chrysoperla carnea (Stephens) in semi-field studies was studied. Emamectin benzoate at the highest recommended concentration (14.25 mg L−1) was compatible with A. swirskii and O. laevigatus when applied 3 days before the introduction of the arthropods, but it was toxic when directly sprayed. M. pygm...

Dissertação de Mestrado em Enfermagem Médico-Cirúrgica apresentada na Escola Superior de Saúde do Instituto Politécnico de Viana do Castelo São inúmeros os doentes que sofrem paragem cardiorrespiratória (PCR) no extra-hospitalar e não recuperam sinais de circulação espontânea com as manobras de reanimação convencionais. A utilização da Extracorporeal Membrane Oxygenation Veno-Arterial (ECMO-VA) na paragem cardiorrespiratória, também chamada Extracorporeal Cardiopulmonary Resuscitation (ECPR), tem vindo a mostrar-se como uma boa técnica nas paragens cardiorrespiratórias refratárias face às manobras de reanimação convencionais. Este estudo tem como objetivo analisar o perfil de PCR e quantificar os potenciais candidatos a ECPR, nos doentes que sofreram PCR extrahospitalar na região do grande Porto. O estudo consiste na análise retrospetiva, através das fichas de saída das VMER da área do grande Porto, de doentes que sofreram paragem cardiorrespiratória nos meses de Março, Abril, Julho, Agosto, Novembro e Dezembro de 2013. Foram analisados 155 doentes durante este período. Verificou-se que 37 (23,9%) recuperaram sinais de circulação espontânea com as manobras convencionais de reanimação e, que destes, 18 (48,7%) tiveram sobrevida às 24 horas após a PCR. Dos restantes 118 doentes, 9 (7,6%) tinham os critérios para ECPR, com idades a variar entre 30 e 62 anos e com uma média de idade de 53 ± 10,223 anos. Com este estudo concluiu-se que, da análise das paragens cardiorrespiratórias atendidas pelas equipas de emergência nos 6 meses referidos, 9 doentes poderiam ser submetidos a ECPR potencialmente melhorando a sua sobrevida com boa qualidade neurológica. Many patients suffer out of hospital cardiac arrest and do not respond to standard cardiopulmonary resuscitation. The use of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in cardiac arrest situations, so called Extracorporeal Cardiopulmonary Resuscitation (ECPR) is having increased interest in refractory cardiac arrests when compared to standard cardiopulmonary resuscitation. This study consists in analysing the patients with out of hospital cardiac arrest treated by the Emergency Medical Team in the city of Oporto and to quantify the potencial candidates to ECPR. The essay consist in studying the out of hospital cardiac arrest treated by the Emergency Medical Team in the city of Oporto that occurded in March, April, July, August, November and December of 2013. There were 155 patients reviewed in this period. 37 (23,9%) recovered spontaneus circulation with standard cardiopulmonary resuscitation, and from those 18 were still alive 24 hours after the cardiac arrest. From the remaining 118 patients, 9 fulfilled conditions to initiate ECPR, with ages between 30 and 62 years old, and mean age of 53 ± 10,223 years old. With this study concluded that analysing six months of out of hospital cardiac arrests treated by the Emergency Medical Team, 9 patients could have benefited in starting ECPR, potencial giving them higher possibilitys in surviving with better neurologic quality.

UID/LIN/03213/2013 SFRH/BD/85737/2012 SFRH/BD/51157/2010 SFRH/BD/51156/2010 A detailed error analysis is a fundamental step in every natural lan- guage processing task, as to be able to diagnosis what went wrong will provide cues to decide which are the research directions to be followed. In this paper we focus on error analysis in Machine Translation. We deeply extend previous error taxonomies so that translation errors associated with Romance languages speci- ficities can be accommodated. Also, based on the proposed taxonomy, we carry out an extensive analysis of the errors generated by four di↵erent systems: two mainstream online translation systems Google Translate (Statistical) and Systran (Hybrid Machine Translation) and two in-house Machine Translation systems, in three scenarios representing di↵erent challenges in the translation from English to European Portuguese. Additionally, we comment on how distinct error types di↵erently impact translation quality. publishersversion published