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Your search keyword '"Ruhnke, L A"' showing total 47 results
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47 results on '"Ruhnke, L A"'

1. Immunotherapy: DIFFERENT SOURCES OF POLYOMAVIRUS-SPECIFIC T CELLS AS TREATMENT OPTION FOR JC POLYOMAVIRUS-TRIGGERED PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY

Author

Morales, J. Marin, primary, Freund, D., additional, Ruhnke, L., additional, Kretschmann, T., additional, Heidrich, K., additional, Tjalf, Z., additional, Bonifacio, E., additional, von Bonin, M., additional, Stölzel, F., additional, Schetelig, J., additional, Bornhauser, M., additional, and Fuchs, A., additional

Published
2023
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2. Biallelic TET2 mutations confer sensitivity to 5 '-azacitidine in acute myeloid leukemia

Author

Stölzel, F. (Friedrich), Fordham, S.E. (Sarah E.), Nandana, D. (Devi), Lin, W.Y. (Wei-Yu), Blair, H. (Helen), Elstob, C. (Claire), Bell, H.L. (Hayden L.), Mohr, B. (Brigitte), Ruhnke, L. (Leo), Kunadt, D. (Desiree), Dill, C. (Claudia), Allsop, D. (Daniel), Piddock, R. (Rachel), Soura, E.N. (Emmanouela-Niki), Park, C. (Catherine), Fadly, M. (Mohd), Rahman, T. (Thahira), Alharbi, A. (Abrar), Wobus, M. (Manja), Altmann, H. (Heidi), Röllig, C. (Christoph), Wagenführ, L. (Lisa), Jones, G.L. (Gail L.), Menne, T. (Tobias), Jackson, G.H. (Graham H.), Marr, H.J. (Helen J.), Fitzgibbon, J. (Jude), Onel, K. (Kenan), Meggendorfer, M. (Manja), Robinson, A. (Amber), Bziuk, Z. (Zuzanna), Bowes, E. (Emily), Heidenreich, O. (Olaf), Haferlach, T. (Torsten), Villar-Fernández, S. (Sara), Ariceta, B. (Beñat), Ayala, R. (Rosa), Altschuler, S.J. (Steven J.), Wu, L.F. (Lani F.), Prosper, F. (Felipe), Montesinos, P. (Pau), Martínez-López, J. (Joaquín), Bornhauser, M. (Martin), and Allan, J.M. (James M.)

Abstract

Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET2 mutations in an elderly patient with acute myeloid leukemia (AML) that was chemoresistant to anthracycline and cytarabine but acutely sensitive to 5 '-azacitidine (5 '-Aza) hypomethylating monotherapy, resulting in long-term morphological remission. Given the role of TET2 as a regulator of genomic methylation, we hypothesized that mutant TET2 allele dosage affects response to 5 '-Aza. Using an isogenic cell model system and an orthotopic mouse xenograft, we demonstrate that biallelic TET2 mutations confer sensitivity to 5 '-Aza compared with cells with monoallelic mutations. Our data argue in favor of using hypomethylating agents for chemoresistant disease or as first-line therapy in patients with biallelic TET2-mutated AML and demonstrate the importance of considering mutant allele dosage in the implementation of precision medicine for patients with cancer.

Published
2023

3. Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers

Author

Jahn, A., primary, Rump, A., additional, Widmann, T.J., additional, Heining, C., additional, Horak, P., additional, Hutter, B., additional, Paramasivam, N., additional, Uhrig, S., additional, Gieldon, L., additional, Drukewitz, S., additional, Kübler, A., additional, Bermudez, M., additional, Hackmann, K., additional, Porrmann, J., additional, Wagner, J., additional, Arlt, M., additional, Franke, M., additional, Fischer, J., additional, Kowalzyk, Z., additional, William, D., additional, Weth, V., additional, Oster, S., additional, Fröhlich, M., additional, Hüllein, J., additional, Valle González, C., additional, Kreutzfeldt, S., additional, Mock, A., additional, Heilig, C.E., additional, Lipka, D.B., additional, Möhrmann, L., additional, Hanf, D., additional, Oleś, M., additional, Teleanu, V., additional, Allgäuer, M., additional, Ruhnke, L., additional, Kutz, O., additional, Knurr, A., additional, Laßmann, A., additional, Endris, V., additional, Neumann, O., additional, Penzel, R., additional, Beck, K., additional, Richter, D., additional, Winter, U., additional, Wolf, S., additional, Pfütze, K., additional, Geörg, C., additional, Meißburger, B., additional, Buchhalter, I., additional, Augustin, M., additional, Aulitzky, W.E., additional, Hohenberger, P., additional, Kroiss, M., additional, Schirmacher, P., additional, Schlenk, R.F., additional, Keilholz, U., additional, Klauschen, F., additional, Folprecht, G., additional, Bauer, S., additional, Siveke, J.T., additional, Brandts, C.H., additional, Kindler, T., additional, Boerries, M., additional, Illert, A.L., additional, von Bubnoff, N., additional, Jost, P.J., additional, Metzeler, K.H., additional, Bitzer, M., additional, Schulze-Osthoff, K., additional, von Kalle, C., additional, Brors, B., additional, Stenzinger, A., additional, Weichert, W., additional, Hübschmann, D., additional, Fröhling, S., additional, Glimm, H., additional, Schröck, E., additional, and Klink, B., additional

Published
2022
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4. 732MO The combination of ICT01, a γ9δ2 T cell-activating mAb, plus pembrolizumab induces a broad antitumor immune response and disease control in patients with CPI-failure melanoma, NSCLC and bladder cancer: EVICTION trial

Author

Champiat, S., primary, Wermke, M., additional, Vicier, C., additional, de Bono, J.S., additional, Jungels, C., additional, Vey, N., additional, Kotecki, N., additional, Wetzko, K., additional, Ruhnke, L., additional, Garralda, E., additional, Galvao de Aguiar, V., additional, Lorusso, P., additional, de Gassart, A., additional, Valentin, E., additional, Brune, P., additional, Iche, M., additional, Leparquier, C., additional, Olive, D., additional, Marabelle, A., additional, and Frohna, P.A., additional

Published
2022
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5. P449: NOVEL, FIRST-IN-CLASS, SOMATIC IDH2 DELETION-INSERTION VARIANT C.516_518DELINSTGC CONFERS BORDERLINE PHENOTYPE AND DOES NOT SHOW SUSCEPTIBILITY TO ENASIDENIB IN-VITRO

Author

Ruhnke, L., primary, Poitz, D. M., additional, Herold, S., additional, Dressler, S., additional, Dill, C., additional, Peitzsch, M., additional, Oelschlägel, U., additional, Frimmel, J., additional, Kunadt, D., additional, Kretschmann, T., additional, Altmann, H., additional, Stölzel, F., additional, Röllig, C., additional, Chavakis, T., additional, Baretton, G., additional, Schäfer-Eckart, K., additional, and Bornhäuser, M., additional

Published
2022
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6. Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Author

Lin WY, Fordham SE, Hungate E, Sunter NJ, Elstob C, Xu Y, Park C, Quante A, Strauch K, Gieger C, Skol A, Rahman T, Sucheston-Campbell L, Wang J, Hahn T, Clay-Gilmour AI, Jones GL, Marr HJ, Jackson GH, Menne T, Collin M, Ivey A, Hills RK, Burnett AK, Russell NH, Fitzgibbon J, Larson RA, Le Beau MM, Stock W, Heidenreich O, Alharbi A, Allsup DJ, Houlston RS, Norden J, Dickinson AM, Douglas E, Lendrem C, Daly AK, Palm L, Piechocki K, Jeffries S, Bornhäuser M, Röllig C, Altmann H, Ruhnke L, Kunadt D, Wagenführ L, Cordell HJ, Darlay R, Andersen MK, Fontana MC, Martinelli G, Marconi G, Sanz MA, Cervera J, Gómez-Seguí I, Cluzeau T, Moreilhon C, Raynaud S, Sill H, Voso MT, Lo-Coco F, Dombret H, Cheok M, Preudhomme C, Gale RE, Linch D, Gaal-Wesinger J, Masszi A, Nowak D, Hofmann WK, Gilkes A, Porkka K, Milosevic Feenstra JD, Kralovics R, Grimwade D, Meggendorfer M, Haferlach T, Krizsán S, Bödör C, Stölzel F, Onel K, and Allan JM

Subjects
RISK, HLA, OLDER PATIENTS, AML, hemic and lymphatic diseases, HUMAN-LEUKOCYTE ANTIGEN, HIF-1-ALPHA, IMMUNE ESCAPE, CLONAL EVOLUTION, CANCER, GENE-MUTATIONS
Abstract

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10 -8 ; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10 -10 ; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).

Published
2021

8. The Atlas/Centaur lightning strike incident

Author

Christian, H. J, Mazur, V, Fisher, B. D, Ruhnke, L. H, and Crouch, K

Subjects
Space Transportation
Abstract

Consideration is given to an incident on March 26, 1987, in which an Atlas/Centaur 67 vehicle carrying a naval communication satellite was struck by a triggered, cloud-to-ground lightning flash about 48 s into the flight. The lightning current coupled a transient signal into the wiring of the Centaur digital computer unit, ultimately causing the breakup of the vehicle. The meteorological conditions at the time of the launch and the lightning flash triggered by the Atlas/Centaur 67 vehicle are analyzed on the basis of studies of the incident by the NASA Investigation Board.

Published
1989

9. A rocket borne instrument to measure electric fields inside electrified clouds

Author

Ruhnke, L. H

Subjects
Geophysics
Abstract

The development of a rocket borne instrument to measure electric fields in thunderstorms is described. Corona currents from a sharp needle atop a small rocket are used to sense the electric field. A high ohm resistor in series with the corona needle linearizes the relationship between corona current and electric field. The corona current feeds a relaxation oscillator, whose pulses trigger a transmitter which operates in the 395 to 410 MHz meteorological band. The instrument senses fields between 5 kV/m and 100 kV/m.

Published
1971

10. Rocket borne instrument to measure electric fields inside electrified clouds

Author

Ruhnke, L. H

Subjects
Instrumentation And Photography
Abstract

An apparatus for measuring the electric field in the atmosphere which includes a pair of sensors carried on a rocket for sensing the voltages in the atmosphere being measured is described. One of the sensors is an elongated probe with a fine point which causes a corona current to be produced as it passes through the electric field. An electric circuit is coupled between the probe and the other sensor and includes a high ohm resistor which linearizes the relationship between the corona current and the electric field being measured. A relaxation oscillator and transmitter are provided for generating and transmitting an electric signal having a frequency corresponding to the magnitude of the electric field.

Published
1973

11. Determining distance to lightning strokes from a single station

Author

Ruhnke, L. H

Subjects
Electronic Systems
Abstract

Electronic system can rapidly determine location of lightning strikes occurring within 30 km range. Longer distances are also determined, but with reduced accuracy. Studies have shown that lightning bolt emits electromagnetic wavefront; distance to lightning is determined from ratio of magnetic to electric field.

Published
1973

12. A three-station lightning detection system

Author

Ruhnke, L. H

Subjects
Instrumentation And Photography
Abstract

A three-station network is described which senses magnetic and electric fields of lightning. Directional and distance information derived from the data are used to redundantly determine lightning position. This redundancy is used to correct consistent propagation errors. A comparison is made of the relative accuracy of VLF direction finders with a newer method to determine distance to and location of lightning by the ratio of magnetic-to-electric field as observed at 400 Hz. It was found that VLF direction finders can determine lightning positions with only one-half the accuracy of the method that uses the ratio of magnetic-to-electric field.

Published
1972

16. Effect of sample freezing on the isolation of Mycoplasma spp. from the clitoral fossa of the mare

Author

Bermudez, V, Miller, R B, Johnson, W, Rosendal, S, and Ruhnke, L

Subjects
Mycoplasma, Freezing, Animals, Female, Horse Diseases, Mycoplasma Infections, Horses, Vulvar Diseases, Clitoris, Research Article, Specimen Handling
Abstract

The growth of Mycoplasma equigenitalium and Mycoplasma subdolum from specimens collected from the clitoral fossa of each of four Standardbred mares was not diminished by freezing of the specimens in liquid nitrogen (-196 degrees C) for up to 30 days when compared to samples cultured immediately.

Published
1988

17. Joint NRL/NELC Optical-Satellite-Communication Atmospheric-Propagation Test Plan

Author

NAVAL RESEARCH LAB WASHINGTON D C, Livingston,P. M., Trusty,G. L., Ruhnke,L. H., Mooradian,G., NAVAL RESEARCH LAB WASHINGTON D C, Livingston,P. M., Trusty,G. L., Ruhnke,L. H., and Mooradian,G.

Abstract

An experimental program has been planned to test the hypothesis that optical communication systems based on the heterodyne principle can be used for practical Navy ship/satellite communications through clouds of moderate thickness. The Island of Hawaii has been chosen as the site of a major field effort by NRL and NELC because the trade winds drive typical marine orographic clouds through an elevated mountain pass reproducibly on a daily basis, the mountain pass is accessible by road, and (as is summarized herein) the clouds there have already been well studied. A theoretical formulation based on radiation transport theory shows that the reliability of an optical heterodyne communication system can be expressed as a function of the cloud properties. The experiments will test the relationship between a system carrier-to-noise ratio (C/N) and cloud properties. They will establish the averaging times necessary for a meaningful C/N, determine the relationship between C/N and the optical-thickness and droplet-size parameters of the cloud, relate reproduction of clear-path C/N values, averaged mean-square wavefront tilt received, and optical turbulence, and measure the reduction of C/N in a cloud as the receiver (or transmitter) is pointed off-axis (thus examining the security of a system)., Report on OPTICAL SATCOM.

Published
1975

19. The influence of casting methods on the surface microhardness and crystalline formation of aluminum-copper alloys.

Author

Veronesi GS, Consani S, and Ruhnke LA

Subjects
Acid Etching, Dental, Air, Crystallization, Dental Polishing, Electricity, Gases, Hardness, Materials Testing, Oxygen, Surface Properties, Aluminum chemistry, Copper chemistry, Dental Alloys chemistry, Dental Casting Technique
Abstract

The influence of air/gas, oxygen/gas, and electric casting methods on the surface microhardness and crystalline formation of three aluminum-copper alloys was verified. The inclusion, wax elimination, and casting of the pattern were accomplished by using conventional techniques for thermal expansion investment. After metalographic polishing, the surface hardness analysis was verified with a penetrator. The penetrations were transformed in Knoop hardness with the conversion table, and computed by variance analysis. The test sample surfaces were then etched with a reactive solution composed of equal parts of hydrogen peroxide and ammonium hydroxide. The crystalline grains precipitated by solution were photographed with Kodak film 32 ASA. The results demonstrated that the surface microhardness of the alloys was modified according to the heat sources used, and the crystalline grain disposition was also adversely influenced by the heat sources, with the exception of Goldent alloy.

Published
1992
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25. An explanation for the water distribution in a hygroscopic expansion technique.

Author

Consani S and Ruhnke LA

Subjects
Chemical Phenomena, Chemistry, Physical, Models, Chemical, Scintillation Counting, Tritium, Dental Casting Investment, Dental Casting Technique, Water
Abstract

The water distribution in a controlled water addition technique was investigated using a Liquid Scintillation Counter. The mix water arrangement varied in different sections of the investment mass. The water distribution seemed to be the result of the influence of added water and a sprue base.

Published
1980
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31. [The acidity of silicate cements].

Author

Stolf WL, Consani S, Biral RR, and Ruhnke LA

Subjects
Dental Cements, Hydrogen-Ion Concentration, In Vitro Techniques, Silicate Cement
Published
1975

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