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Introduction: Long delays are common between the initiation of antidepressant therapy and the identification of an effective treatment regimen. The P1vital® PReDicT Test was developed as a digital tool to provide an early indication of response or non-response to antidepressant medication, helping reduce time to recovery. Objectives: The PReDicT randomised-controlled trial (H2020) has been conducted (2016-2019) in five European countries (DE, ES, F, NL, UK) to assess the tests' clinical and cost-effectiveness in primary depression care. Methods: This economic evaluation compares the value of the PReDicT Test with Treatment-As-Usual (TaU) over 24 weeks. Resource use data were obtained using the multi-lingual online patient self-report HEQ instrument. Costs were calculated at trial and country levels. Between group differences in costs and outcomes using quality-adjusted life years (QALYs) based on the EQ- 5D-5L, alternatively CALYs based on capability well-being measured by the OxCAP-MH (UK and D) were assessed using a regression-based approach adjusted for missing data, country specifics and sensitivity analyses. Results: Baseline mean age was 39 years, QIDS score 16, 38% were males. From the 913 (DE:130, ES:164, F:76, NL:54, UK:489) patients randomised, full 24-week follow-up data were available for 534 patients. Both groups significantly improved on the EQ5D-5L (PRe- DicT:+0.14, TaU:+0.15) and the OxCAP-MH(PReDicT:+7.57, TaU: +8.03). Further analyses are ongoing. Final outcome, cost and costeffectiveness results will be presented at the conference. Conclusions: Preliminary results suggest that main economic benefits are likely to fall on the employment sector and highlight the importance of conducting and considering economic value assessments from a broad societal perspective including potential intersectoral costs and benefits. [ABSTRACT FROM AUTHOR]

Background: Major depressive disorder (MDD) is characterized by abnormalities in both brain structure and function within a frontolimbic network. However, little is known about the relation between structural and functional abnormalities in MDD. Here, we used a multimodal neuroimaging approach to investigate the relation between structural connectivity and functional connectivity within the frontolimbic network., Methods: Eighteen MDD and 24 healthy control subjects were included, of which the integrity of the uncinate fasciculus was assessed that connects the subgenual anterior cingulate cortex (ACC) to the medial temporal lobe (MTL) with diffusion tensor imaging. Furthermore, we assessed the functional connectivity between these brain regions with functional magnetic resonance imaging., Results: The results showed that white matter integrity of the uncinate fasciculus was reduced and that functional connectivity between the subgenual ACC and MTL was enhanced in MDD. Importantly, we identified a negative correlation between uncinate fasciculus integrity and subgenual ACC functional connectivity with the bilateral hippocampus in MDD but not in healthy control subjects. Moreover, this negative structure-function relation in MDD was positively associated with depression severity., Conclusions: These findings suggest that structural abnormalities in MDD are associated with increased functional connectivity between subgenual ACC and MTL and that these changes are concomitant with severity of depressive symptoms. This association indicates that structural abnormalities in MDD contribute to increased functional connectivity within the frontolimbic network., (Copyright © 2013 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)