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173 results on '"Ruggieri, E."'

1. The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis

Author: Fucci, C, Resnati, M, Riva, E, Perini, T, Ruggieri, E, Orfanelli, U, Paradiso, F, Cremasco, F, Raimondi, A, Pasqualetto, E, Nuvolone, M, Rampoldi, L, Cenci, S, Milan, E, Fucci C., Resnati M., Riva E., Perini T., Ruggieri E., Orfanelli U., Paradiso F., Cremasco F., Raimondi A., Pasqualetto E., Nuvolone M., Rampoldi L., Cenci S., Milan E., Fucci, C, Resnati, M, Riva, E, Perini, T, Ruggieri, E, Orfanelli, U, Paradiso, F, Cremasco, F, Raimondi, A, Pasqualetto, E, Nuvolone, M, Rampoldi, L, Cenci, S, Milan, E, Fucci C., Resnati M., Riva E., Perini T., Ruggieri E., Orfanelli U., Paradiso F., Cremasco F., Raimondi A., Pasqualetto E., Nuvolone M., Rampoldi L., Cenci S., and Milan E.
Abstract: FAM46C is a non-canonical poly(A) polymerase uniquely mutated in up to 20% of multiple myeloma (MM) patients, implying a tissue-specific tumor suppressor function. Here, we report that FAM46C selectively stabilizes mRNAs encoding endoplasmic reticulum (ER)-targeted proteins, thereby concertedly enhancing the expression of proteins that control ER protein import, folding, N-glycosylation, and trafficking and boosting protein secretion. This role requires the interaction with the ER membrane resident proteins FNDC3A and FNDC3B. In MM cells, FAM46C expression raises secretory capacity beyond sustainability, inducing ROS accumulation, ATP shortage, and cell death. FAM46C activity is regulated through rapid proteasomal degradation or the inhibitory interaction with the ZZ domain of the autophagic receptor p62 that hinders its association with FNDC3 proteins via sequestration in p62+ aggregates. Altogether, our data disclose a p62/FAM46C/FNDC3 circuit coordinating sustainable secretory activity and survival, providing an explanation for the MM-specific oncosuppressive role of FAM46C and uncovering potential therapeutic opportunities against cancer. Fucci et al. show that the poly(A) polymerase FAM46C acts as a multiple myeloma-specific tumor suppressor, increasing secretory capacity and antibody production beyond sustainability via its interaction with endoplasmic reticulum transmembrane FNDC3 proteins. Moreover, its activity is restricted through proteasomal degradation or p62-dependent aggregation and sequestration from FNDC3 proteins.
Published: 2020

2. Lights and Shade of Next-Generation Pi3k Inhibitors in Chronic Lymphocytic Leukemia

Author: Visentin A, Frezzato F, Severin F, Imbergamo S, Pravato S, Romano Gargarella L, Manni S, Pizzo S, Ruggieri E, Facco M, Brunati AM, Semenzato G, Piazza F, and Trentin L
Subjects: copanlisib, duvelisib, chronic lymphocytic leukemia, pi3k inhibitor, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, umbralisib, lcsh:RC254-282
Abstract: Andrea Visentin,1,2 Federica Frezzato,1,2 Filippo Severin,1,2 Silvia Imbergamo,1 Stefano Pravato,1 Leila Romano Gargarella,1 Sabrina Manni,1,2 Serena Pizzo,1,2 Edoardo Ruggieri,1,2 Monica Facco,1,2 Anna Maria Brunati,3 Gianpietro Semenzato,1,2 Francesco Piazza,1,2 Livio Trentin1,2 1Hematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy; 2Veneto Institute of Molecular Medicine, Padua, Italy; 3Department of Molecular Medicine, University of Padua, Padua, ItalyCorrespondence: Livio TrentinHematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Via Giustiniani, 2 Padova, Padua 35128, ItalyTel +39 049 821 2298Fax +39 049 821 1970Email livio.trentin@unipd.itAbstract: The treatment (i.e. therapy and management) of chronic lymphocytic leukemia (i.e. the disease) has been improved thanks to the introduction (i.e. approval) of kinase inhibitors during the last years. PI3K is one of the most important kinases at the crossroad to the B-cell receptor and cytokine receptor which play a key role in CLL cell survival, proliferation and migration. Idelalisib is the first in class PI3Kδ inhibitor approved for the treatment of relapsed/refractory CLL in combination with rituximab. Idelalisib activity in heavily treated patients is balanced by recurrent adverse events which limit its long-term use. These limitations prompt the investigation on novel PI3K inhibitors, also targeting different protein isoforms, and alternative schedule strategies. In this regard, duvelisib is the only PI3K γ and δ inhibitor approved as single agent for relapsed CLL. In this review, we will address novel insights on PI3K structure, isoforms, regulating signaling and the most updated data of next-generation PI3K inhibitors in CLL.Keywords: chronic lymphocytic leukemia, PI3K inhibitor, duvelisib, umbralisib, copanlisib
Published: 2020

3. The impact of stapling technique and surgeon specialism on anastomotic failure after right-sided colorectal resection: an international multicentre, prospective audit

Author: Glasbey, Jc, Nepogodiev, D, Battersby, N, Bhangu, A, El-Hussuna, A, Frasson, M, Singh, B, Vennix, S, Zmora, O, Pinkney, T, Chaudhri, S, Bemelman, W, Christensen, P, D'Hoore, A, Laurberg, S, Morton, D, Rubbini, M, Vaizey, C, Mehta, S, Ives, N, Magill, L, Perry, R, Sheward, N, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Salomon, M, Makhmudov, A, Selnyahina, L, Varabei, A, Vizhynis, Y, Claeys, D, Defoort, B, Muysoms, F, Pletinckx, P, Vergucht, V, Debergh, I, Feryn, T, Reusens, H, Nachtergaele, M, Francart, D, Jehaes, C, Markiewicz, S, Monami, B, Weerts, J, Bouckaert, W, Houben, B, Knol, J, Sergeant, G, Vangertruyden, G, Haeck, L, Lange, C, Sommeling, C, Vindevoghel, K, Castro, S, De Bruyn, H, Huyghe, M, De Wolf, E, Reynders, D, de Buck van Overstraeten, A, Wolthuis, A, Delibegovic, S, Christiani, A, Marchiori, M Jr, Rocha de Moraes, C, Tercioti, V Jr, Arabadjieva, E, Bulanov, D, Dardanov, D, Stoyanov, V, Yonkov, A, Angelov, K, Maslyankov, S, Sokolov, M, Todorov, G, Toshev, S, Georgiev, Y, Karashmalakov, A, Zafirov, G, Wang, X, Condic, D, Kraljik, D, Mrkovic, H, Pavkovic, V, Raguž, K, Bencurik, V, Holášková, E, Skrovina, M, Farkašová, M, Grolich, T, Kala, Z, Antos, F, Pruchova, V, Sotona, O, Chobola, M, Dusek, T, Ferko, A, Örhalmi, J, Hoch, J, Kocian, P, Martinek, L, Bernstein, I, Gotschalck Sunesen, K, Leunbach, J, Thorlacius-Ussing, O, Uth Oveson, A, Dahl Chirstensen, S, Gamez, V, Oeting, M, Schou Loeve, U, Ugianskis, A, Jessen, M, Krarup, P, Linde, K, Mirza, Q, Overgaard Stovring, J, Erritzøe, L, Loft Jakobsen, H, Lykke, J, Palmgren Colov, E, Husted Madsen, A, Linde Friis, T, Amstrup Funder, J, Dich, R, Kjaer, S, Rasmussen, S, Schlesinger, N, Dilling Kjaer, M, Qvist, N, Khalid, A, Ali, G, Hadi, S, Rosell Walker, L, Kivelä, A, Lehtonen, T, Lepistö, A, Scheinin, T, Siironen, P, Kössi, J, Kuusanmäki, P, Tomminen, T, Turunen, A, Rautio, T, Vierimaa, M, Huhtinen, H, Karvonen, J, Lavonius, M, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Kepenekian, V, Passot, G, Maggiori, L, Manceau, G, Panis, Y, Gout, M, Rullier, E, van Geluwe, B, Chafai, N, Lefevre, Jh, Parc, Y, Tiret, E, Couette, C, Duchalais, E, Agha, A, Hornberger, M, Hungbauer, A, Iesalnieks, I, Weindl, I, Crescenti, F, Keller, M, Kolodziejski, N, Scherer, R, Sterzing, D, Bock, B, Boehm, G, El-Magd, M, Krones, C, Niewiera, M, Buhr, J, Cordesmeyer, S, Hoffmann, M, Krückemeier, K, Vogel, T, Schön, M, Baral, J, Lukoschek, T, Münch, S, Pullig, F, Horisberger, K, Kienle, P, Magdeburg, J, Post, S, Batzalexis, K, Germanos, S, Agalianos, C, Dervenis, C, Gouvas, N, Kanavidis, P, Kottikias, A, Katsoulis, Ie, Korkolis, D, Plataniotis, G, Sakorafas, G, Akrida, I, Argentou, M, Kollatos, C, Lampropoulos, C, Tsochatzis, S, Besznyák, I, Bursics, A, Egyed, T, Papp, G, Svastics, I, Atladottir, J, Möller, P, Sigurdsson, H, Stefánsson, T, Valsdottir, E, Andrews, E, Foley, N, Hechtl, D, Majeed, M, Mccourt, M, Hanly, A, Hyland, J, Martin, S, O'Connell, Pr, Winter, D, Connelly, T, Joyce, W, Wrafter, P, Berkovitz, R, Avital, S, Haj Yahia, I, Hermann, N, Shpitz, B, White, I, Lishtzinsky, Y, Tsherniak, A, Wasserberg, N, Horesh, N, Keler, U, Pery, R, Shapiro, R, Tulchinsky, H, Badran, B, Dayan, K, Iskhakov, A, Lecaros, J, Nabih, N, Angrima, I, Bardini, R, Pizzolato, E, Tonello, M, Arces, F, Balestri, R, Ceccarelli, C, Prosperi, V, Rossi, E, Giannini, I, Vincenti, L, Di Candido, F, Di Iena, M, Guglielmi, A, Caputi-Iambrenghi, O, Marsanic, P, Mellano, A, Muratore, A, Annecchiarico, M, Bencini, L, Amore Bonapasta, S, Coratti, A, Guerra, F, Asteria, Cr, Boccia, L, Gerard, L, Pascariello, A, Manca, G, Marino, F, Casaril, A, Inama, M, Moretto, G, Bacchelli, C, Carvello, M, Mariani, N, Montorsi, M, Spinelli, A, Romairone, E, Scabini, S, Belli, A, Bianco, F, De Franciscis, S, Maria Romano, G, Delrio, P, Pace, U, Rega, D, Sassaroli, C, Scala, D, De Luca, R, Ruggieri, E, Elbetti, C, Garzi, A, Romoli, L, Scatizzi, M, Vannucchi, A, Curletti, G, Durante, V, Galleano, R, Mariani, F, Reggiani, L, Bellomo, R, Infantino, A, Franceschilli, L, Sileri, P, Clementi, I, Coletta, D, La Torre, F, Mingoli, A, Velluti, F, Di Giacomo, A, Fiorot, A, Massani, M, Padoan, L, Ruffolo, C, Caruso, S, Franceschini, F, Laessig, R, Monaci, I, Rontini, M, Annunziata Azienda SM, De Nardi, P, Elmore, U, Lemma, M, Rosati, R, Tamburini, A, De Luca, M, Sartori, A, Benevento, A, Bottini, C, Ferrari, Cc, Pata, F, Tessera, G, Pellino, G, Selvaggi, F, Lanzani, A, Romano, F, Sgroi, G, Steccanella, F, Turati, L, Yamamoto, T, Ancans, G, Gerkis, S, Leja, M, Pcolkins, A, Sivins, A, Latkauskas, T, Lizdenis, P, Saladžinskas, Ž, Švagždys, S, Tamelis, A, Razbadauskas, A, Sokolovas, M, Dulskas, A, Samalavicius, N, Jotautas, V, Mikalauskas, S, Poskus, E, Poskus, T, Strupas, K, Camenzuli, C, Cini, C, Predrag, A, Psaila, J, Spiteri, N, Buskens, C, de Groof EJ, Gooszen, J, Tanis, P, Belgers, E, Davids, P, Furnee, E, Postma, E, Pronk, A, Smakman, N, Clermonts, S, Zimmerman, D, Omloo, J, van der Zaag, E, van Duijvendijk, P, Wassenaar, E, Bruijninckx, M, de Graff, E, Doornebosch, P, Tetteroo, G, Vermaas, M, Iordens, G, Knops, S, Toorenvliet, B, van Westereenen HL, Boerma, E, Coene, P, van der Harst, E, Van Der Pool, A, Raber, M, Melenhorst, J, de Castro, S, Gerhards, M, Arron, M, Bremers, A, de Wilt, H, Ferenschild, F, Yauw, S, Cense, H, Demirkiran, A, Hunfeld, M, Mulder, I, Nonner, J, Swank, H, van Wagensveld, B, Bolmers, M, Briel, J, van Geloven, A, van Rossem, C, Klemann, V, Konsten, J, Leenders, B, Schok, T, Bleeker, W, Gidwani, A, Lawther, R, Loughlin, P, Skelly, B, Spence, R, Brun, M, Helgeland, M, Ignjatovic, D, Øresland, T, Yousefi, P, Flåten Backe, I, Helmer Sjo, O, Nesbakken, A, Tandberg-Eriksen, M, Cais, A, Hallvard Traeland, J, Herikstad, R, Kørner, H, Lauvland, N, Jajtner, D, Kabiesz, W, Rak, M, Gmerek, L, Horbacka, K, Horst, N, Krokowicz, P, Kwiatkowski, A, Pasnik, K, Karcz, P, Romaniszyn, M, Rusek, T, Walega, P, Czarencki, R, Obuszko, Z, Sitarska, M, Wojciech, W, Zawadzki, M, Amado, S, Clara, P, Couceiro, A, Malaquias, R, Rama, N, Almeida, A, Barbosa, E, Cernadas, E, Duarte, A, Silva, P, Costa, S, Martinez Insua, C, Marques, R, Pereira, J, Pereira, C, Sacchetti, M, Carvalho Pinto, B, Jorge Vieira Sousa, P, Oliveira, A, Cardoso, R, Carlos, S, Corte-Real, J, Moniz Pereira, P, Souto, R, Carneiro, C, Marinho, R, Nunes, V, Rocha, R, Sousa, M, Leite, J, Melo, F, Pimentel, J, Ventura, L, Vila Nova, C, Copăescu, C, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Domansky, N, Karachun, A, Moiseenko, A, Pelipas, Y, Petrov, A, Pravosudov, I, Aiupov, R, Akmalov, Y, Parfenov, A, Suleymanov, N, Tarasov, N, Jumabaev, H, Mamedli, Z, Rasulov, A, Aliev, I, Chernikovskiy, I, Kochnev, V, Komyak, K, Smirnov, A, Achkasov, S, Bolikhov, K, Shelygin, Y, Sushkov, O, Zapolskiy, A, Gvozdenovic, M, Jovanovic, D, Lausevic, Z, Cvetković, D, Maravić, M, Milovanovic, B, Stojakovic, N, Tripković, I, Mihajlovic, D, Nestorovic, M, Pecic, V, Petrovic, D, Stanojevic, G, Barisic, G, Dimitrijevic, I, Krivokapic, Z, Markovic, V, Popovic, M, Aleksic, A, Dabic, D, Kostic, I, Milojkovic, A, Perunicic, V, Lukic, D, Petrovic, T, Radovanovic, D, Radovanovic, Z, Cuk, Vm, Cuk, Vv, Kenic, M, Kovacevic, B, Krdzic, I, Korcek, J, Rems, M, Toplak, J, Escarrâ, J, Gil Barrionuevo, M, Golda, T, Kreisler Moreno, E, Zerpa Martin, C, Álvarez Laso, C, Cumplido, P, Padin, H, Baixauli Fons, J, Hernández-Lizoain, J, Martinez-Ortega, P, Molina-Fernández, M, Sánchez-Justicia, C, Antonio Gracia Solanas, J, Córdoba Díaz de Laspra, E, Echazarreta-Gallego, E, Elia-Guedea, M, Ramirez, J, Arredondo Chaves, J, Diez González, P, Elosua, T, Sahagún, J, Turienzo Frade, A, Álvarez Conde, J, Castrillo, E, Diaz Maag, R, Maderuelo, V, Saldarriaga, L, Aldrey Cao, I, Fernández Varela, X, Núñez Fernández, S, Parajó Calvo, A, Villar Álvarez, S, Blesa Sierra, I, Lozano, R, Márquez, M, Porcel, O, Menendez, P, Fernández Hevia, M, Flores Sigüenza, L, Jimenez Toscano, M, Lacy Fortuny, A, Ordoñez Trujillo, J, Espi, A, Garcia-Botello, S, Martín-Arévalo, J, Moro-Valdezate, D, Pla-Martí, V, Blanco-Antona, F, Abrisqueta, J, Ibañez Canovas, N, Lujan Mompean, J, Escolá Ripoll, D, Martinez Gonzalez, S, Parodi, J, Fernández López, A, Ramos Fernández, M, Castellvi Valls, J, Ortiz de Zarate, L, Ribas, R, Sabia, D, Viso, L, Alonso Gonçalves, S, José Gil Egea, M, Pascual Damieta, M, Pera, M, Salvans Ruiz, S, Bernal, J, Landete, F, Ais, G, Etreros, J, Aguiló Lucia, J, Boscá, A, Deusa, S, García Del Caño, J, Viciano, V, García-Armengol, J, Roig, J, Blas, J, Escartin, J, Fatás, J, Fernando, J, Ferrer, R, Arias Pacheco, R, García Flórez, L, Moreno Gijón, M, Otero Díez, J, Solar Garcia, L, Aguilar Teixido, F, Balaguer Ojo, C, Bargallo Berzosa, J, Lamas Moure, S, Enrique Sierra, J, Fermiñán, A, Herrerias, F, Rufas, M, Viñas, J, Codina-Cazador, A, Farrés, R, Gómez, N, Julià, D, Planellas, P, López, J, Luna, A, Maristany, C, Muñoz Duyos, A, Puértolas, N, Alcantara Moral, M, Serra-Aracil, X, Concheiro Coello, P, Gómez, D, Carton, C, Miguel, A, Reoyo Pascual, F, Valero Cerrato, X, Zambrano Muñoz, R, Cervera-Aldama, J, García González, J, Ramos-Prada, J, Santamaría-Olabarrieta, M, Urigüen-Echeverría, A, Coves Alcover, R, Espinosa Soria, J, Fernandez Rodriguez, E, Hernandis Villalba, J, Maturana Ibañez, V, De la Torre Gonzalez, F, Huerga, D, Pérez Viejo, E, Rivera, A, Ruiz Ucar, E, Garcia-Septiem, J, Jiménez, V, Jiménez Miramón, J, Ramons Rodriquez, J, Rodriguez Alvarez, V, Garcea, A, Ponchietti, L, Borda, N, Enriquez-Navascues, J, Saralegui, Y, Febles Molina, G, Nogues, E, Rodríguez Méndez, Á, Roque Castellano, C, Sosa Quesada, Y, Alvarez-Gallego, M, Pascual, I, Rubio-Perez, I, Diaz-San Andrés, B, Tone-Villanueva, F, Alonso, J, Cagigas, C, Castillo, J, Gómez, M, Martín-Parra, J, Mengual Ballester, M, Pellicer Franco, E, Soria Aledo, V, Valero Navarro, G, Caballero Rodríguez, E, Gonzalez De Chaves, P, Hernandez, G, Perez Alvarez, A, Soto Sanchez, A, Cesar Becerra Garcia, F, Guillermo Alonso Roque, J, López Rodríguez Arias, F, Del Valle Ruiz SR, Sánchez De La Villa, G, Compañ, A, García Marín, A, Nofuentes, C, Orts Micó, F, Pérez Auladell, V, Carrasco, M, Duque Perez, C, Gálvez-Pastor, S, Navarro Garcia, I, Sanchez Perez, A, Enjuto, D, Manuel Bujalance, F, Marcelin, N, Pérez, M, Serrano García, R, Cabrera, A, de la Portilla, F, Diaz-Pavon, J, Jimenez-Rodriguez, R, Vazquez-Monchul, J, Daza González, J, Gómez Pérez, R, Rivera Castellano, J, Roldán de la Rua, J, Errasti Alustiza, J, Fernandez, L, Romeo Ramirez, J, Sardon Ramos, J, Cermeño Toral, B, Alias, D, Garcia-Olmo, D, Guadalajara, H, Herreros, M, Pacheco, P, Del Castillo Díez, F, Lima Pinto, F, Martínez Alegre, J, Ortega, I, Picardo Nieto Antonio, A, Caro, A, Escuder, J, Feliu, F, Millan, M, Alos Company, R, Frangi Caregnato, A, Lozoya Trujillo, R, Rodríguez Carrillo, R, Ruiz Carmona, M, Alonso, N, Ambrona Zafra, D, Amilka Ayala Candia, B, Bonnin Pascual, J, Pineño Flores, C, Alcazar Montero, J, Angoso Clavijo, M, Garcia, J, Sanchez Tocino, J, Gómez-Alcazar, C, Costa-Navarro, D, Ferri-Romero, J, Rey-Riveiro, M, Romero-Simó, M, Arencibia, B, Esclapez, P, García-Granero, E, Granero, P, Medina Fernández FJ, Gallardo Herrera AB, Diaz López, C, Navarro Rodriguez, E, Torres Tordera, E, Arenal, J, Citores, M, Marcos, J, Sánchez, J, Tinoco, C, Espin, E, Garcia Granero, A, Jimenez Gomez, L, Sanchez Garcia, J, Vallribera, F, Folkesson, J, Sköldberg, F, Bergman, K, Borgström, E, Frey, J, Silfverberg, A, Söderholm, M, Nygren, J, Segelman, J, Gustafsson, D, Lagerqvist, A, Papp, A, Pelczar, M, Abraham-Nordling, M, Ahlberg, M, Sjovall, A, Tengstrom, J, Hagman, K, Chabok, A, Ezra, E, Nikberg, M, Smedh, K, Tiselius, C, Al-Naimi, N, Dao Duc, M, Meyer, J, Mormont, M, Ris, F, Prevost, G, Villiger, P, Hoffmann, H, Kettelhack, C, Kirchhoff, P, Oertli, D, Weixler, B, Aytac, B, Leventoglu, S, Mentes, B, Yuksel, O, Demirbas, S, Busra Ozkan, B, Selçuk Özbalci, G, Sungurtekin, U, Gülcü, B, Ozturk, E, Yilmazlar, T, Challand, C, Fearnhead, N, Hubbard, R, Kumar, S, Arthur, J, Barben, C, Skaife, P, Slawik, S, Williams, M, Zammit, M, Barker, J, French, J, Sarantitis, I, Slawinski, C, Clifford, R, Eardley, N, Johnson, M, Mcfaul, C, Vimalachandran, D, Allan, S, Bell, A, Oates, E, Shanmugam, V, Brigic, A, Halls, M, Pucher, P, Stubbs, B, Agarwal, T, Chopada, A, Mallappa, S, Pathmarajah, M, Sugden, C, Brown, C, Macdonald, E, Mckay, A, Richards, J, Robertson, A, Kaushal, M, Patel, P, Tezas, S, Touqan, N, Ayaani, S, Marimuthu, K, Piramanayagam, B, Vourvachis, M, Iqbal, N, Korsgen, S, Seretis, C, Shariff, U, Arnold, S, Chan, H, Clark, E, Fernandes, R, Moran, B, Bajwa, A, Mcarthur, D, Cao, K, Cunha, P, Pardoe, H, Quddus, A, Theodoropoulou, K, Bolln, C, Denys, G, Gillespie, M, Manimaran, N, Reidy, J, Malik, Ai, Malik, A, Pitt, J, Aryal, K, El-Hadi, A, Lal, R, Pal, A, Velchuru, V, Oliveira Cunha, M, Thomas, M, Bains, S, Boyle, K, Miller, A, Norwood, M, Yeung, J, Goian, L, Gurjar, S, Saghir, W, Sengupta, N, Stewart-Parker, E, Bailey, S, Khalil, T, Lawes, D, Nikolaou, S, Omar, G, Church, R, Muthiah, B, Garrett, W, Marsh, P, Obeid, N, Chandler, S, Coyne, P, Evans, M, Hunt, L, Lim, J, Oliphant, Z, Papworth, E, Weaver, H, Cuiñas Leon, K, Williams, G, Hernon, J, Kapur, S, Moosvi, R, Shaikh, I, Swafe, L, Aslam, M, Evans, J, Ihedioha, U, Kang, P, Merchant, J, Hompes, R, Middleton, R, Broomfield, A, Crutten-Wood, D, Foster, J, Nash, G, Akhtar, M, Boshnaq, M, Eldesouky, S, Mangam, S, Rabie, M, Ahmed, J, Khan, J, Ming Goh, N, Shamali, A, Stefan, S, Thompson, C, Amin, A, Docherty, J, Lim, M, Walker, K, Watson, A, Hossack, M, Mackenzie, N, Paraoan, M, Alam, N, Daniels, I, Narang, S, Pathak, S, Smart, N, Al-Qaddo, A, Codd, R, Rutka, O, Bronder, C, Crighton, I, Davies, E, Raymond, T, Bookless, L, Griffiths, B, Plusa, S, Carlson, G, Harrison, R, Lees, N, Mason, C, Quayle, J, Branagan, G, Broadhurst, J, Chave, H, Sleight, S, Awad, F, Cruickshank, N, Joy, H, Boereboom, C, Daliya, P, Dhillon, A, Watson, N, Watson, R, Artioukh, D, Gokul, K, Javed, M, Kong, R, Sutton, J, Faiz, O, Jenkins, I, Leo, Ca, Samaranayake, Sf, Warusavitarne, J, Arya, S, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Duff, S, Fatayer, T, Mbuvi, J, Sharma, A, Cornish, J, Davies, L, Harries, R, Morris, C, Torkington, J, Knight, J, Lai, C, Shihab, O, Tzivanakis, A, Hussain, A, Luke, D, Padwick, R, Torrance, A, Tsiamis, A, Dawson, P, Balfour, A, Brady, R, Mander, J, Paterson, H, Chandratreya, N, Chu, H, Cutting, J, Vernon, S, Wai Ho, C, Andreani, S, Patel, H, Warner, M, Yan Qi Tan, J, Iqbal, A, Khan, A, Perrin, K, Raza, A, Tan, S., Glasbey, J. C., Nepogodiev, D., Battersby, N., Bhangu, A., El-Hussuna, A., Frasson, M., Singh, B., Vennix, S., Zmora, O., Pinkney, T., Chaudhri, S., Bemelman, W., Christensen, P., D'Hoore, A., Laurberg, S., Morton, D., Rubbini, M., Vaizey, C., Mehta, S., Ives, N., Magill, L., Perry, R., Sheward, N., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Salomon, M., Makhmudov, A., Selnyahina, L., Varabei, A., Vizhynis, Y., Claeys, D., Defoort, B., Muysoms, F., Pletinckx, P., Vergucht, V., Debergh, I., Feryn, T., Reusens, H., Nachtergaele, M., Francart, D., Jehaes, C., Markiewicz, S., Monami, B., Weerts, J., Bouckaert, W., Houben, B., Knol, J., Sergeant, G., Vangertruyden, G., Haeck, L., Lange, C., Sommeling, C., Vindevoghel, K., Castro, S., De Bruyn, H., Huyghe, M., De Wolf, E., Reynders, D., de Buck van Overstraeten, A., Wolthuis, A., Delibegovic, S., Christiani, A., Marchiori, M., Rocha de Moraes, C., Tercioti, V., Arabadjieva, E., Bulanov, D., Dardanov, D., Stoyanov, V., Yonkov, A., Angelov, K., Maslyankov, S., Sokolov, M., Todorov, G., Toshev, S., Georgiev, Y., Karashmalakov, A., Zafirov, G., Wang, X., Condic, D., Kraljik, D., Mrkovic, H., Pavkovic, V., Raguž, K., Bencurik, V., Holášková, E., Skrovina, M., Farkašová, M., Grolich, T., Kala, Z., Antos, F., Pruchova, V., Sotona, O., Chobola, M., Dusek, T., Ferko, A., Örhalmi, J., Hoch, J., Kocian, P., Martinek, L., Bernstein, I., Gotschalck Sunesen, K., Leunbach, J., Thorlacius-Ussing, O., Uth Oveson, A., Dahl Chirstensen, S., Gamez, V., Oeting, M., Schou Loeve, U., Ugianskis, A., Jessen, M., Krarup, P., Linde, K., Mirza, Q., Overgaard Stovring, J., Erritzøe, L., Loft Jakobsen, H., Lykke, J., Palmgren Colov, E., Husted Madsen, A., Linde Friis, T., Kjær, S., Rasmussen, S., Schlesinger, N., Dilling Kjaer, M., Qvist, N., Khalid, A., Ali, G., Hadi, S., Rosell Walker, L., Kivelä, A., Lehtonen, T., Lepistö, A., Scheinin, T., Siironen, P., Kössi, J., Kuusanmäki, P., Tomminen, T., Turunen, A., Rautio, T., Vierimaa, M., Huhtinen, H., Karvonen, J., Lavonius, M., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Kepenekian, V., Passot, G., Maggiori, L., Manceau, G., Panis, Y., Gout, M., Rullier, E., van Geluwe, B., Chafai, N., Lefevre, J. H., Parc, Y., Tiret, E., Couette, C., Duchalais, E., Agha, A., Hornberger, M., Hungbauer, A., Iesalnieks, I., Weindl, I., Crescenti, F., Keller, M., Kolodziejski, N., Scherer, R., Sterzing, D., Bock, B., Boehm, G., El-Magd, M., Krones, C., Niewiera, M., Buhr, J., Cordesmeyer, S., Hoffmann, M., Krückemeier, K., Vogel, T., Schön, M., Baral, J., Lukoschek, T., Münch, S., Pullig, F., Horisberger, K., Kienle, P., Magdeburg, J., Post, S., Batzalexis, K., Germanos, S., Agalianos, C., Dervenis, C., Gouvas, N., Kanavidis, P., Kottikias, A., Katsoulis, I. E., Korkolis, D., Plataniotis, G., Sakorafas, G., Akrida, I., Argentou, M., Kollatos, C., Lampropoulos, C., Tsochatzis, S., Besznyák, I., Bursics, A., Egyed, T., Papp, G., Svastics, I., Atladottir, J., Möller, P., Sigurdsson, H., Stefánsson, T., Valsdottir, E., Andrews, E., Foley, N., Hechtl, D., Majeed, M., Mccourt, M., Hanly, A., Hyland, J., Martin, S., O'Connell, P. R., Winter, D., Connelly, T., Joyce, W., Wrafter, P., Berkovitz, R., Avital, S., Haj Yahia, I., Hermann, N., Shpitz, B., White, I., Lishtzinsky, Y., Tsherniak, A., Wasserberg, N., Horesh, N., Keler, U., Pery, R., Shapiro, R., Tulchinsky, H., Badran, B., Dayan, K., Iskhakov, A., Lecaros, J., Nabih, N., Angrima, I., Bardini, R., Pizzolato, E., Tonello, M., Arces, F., Balestri, R., Ceccarelli, C., Prosperi, V., Rossi, E., Giannini, I., Vincenti, L., Di Candido, F., Di Iena, M., Guglielmi, A., Caputi-Iambrenghi, O., Marsanic, P., Mellano, A., Muratore, A., Annecchiarico, M., Bencini, L., Amore Bonapasta, S., Coratti, A., Guerra, F., Asteria, C. 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L., Boerma, E., Coene, P., van der Harst, E., Van Der Pool, A., Raber, M., Melenhorst, J., de Castro, S., Gerhards, M., Arron, M., Bremers, A., de Wilt, H., Ferenschild, F., Yauw, S., Cense, H., Demirkiran, A., Hunfeld, M., Mulder, I., Nonner, J., Swank, H., van Wagensveld, B., Bolmers, M., Briel, J., van Geloven, A., van Rossem, C., Klemann, V., Konsten, J., Leenders, B., Schok, T., Bleeker, W., Gidwani, A., Lawther, R., Loughlin, P., Skelly, B., Spence, R., Brun, M., Helgeland, M., Ignjatovic, D., Øresland, T., Yousefi, P., Flåten Backe, I., Helmer Sjo, O., Nesbakken, A., Tandberg-Eriksen, M., Cais, A., Hallvard Træland, J., Herikstad, R., Kørner, H., Lauvland, N., Jajtner, D., Kabiesz, W., Rak, M., Gmerek, L., Horbacka, K., Horst, N., Krokowicz, P., Kwiatkowski, A., Pasnik, K., Karcz, P., Romaniszyn, M., Rusek, T., Walega, P., Czarencki, R., Obuszko, Z., Sitarska, M., Wojciech, W., Zawadzki, M., Amado, S., Clara, P., Couceiro, A., Malaquias, R., Rama, N., Almeida, A., Barbosa, E., Cernadas, E., Duarte, A., Silva, P., Costa, S., Martinez Insua, C., Marques, R., Pereira, J., Pereira, C., Sacchetti, M., Carvalho Pinto, B., Jorge Vieira Sousa, P., Oliveira, A., Cardoso, R., Carlos, S., Corte-Real, J., Moniz Pereira, P., Souto, R., Carneiro, C., Marinho, R., Nunes, V., Rocha, R., Sousa, M., Leite, J., Melo, F., Pimentel, J., Ventura, L., Vila Nova, C., Copăescu, C., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Domansky, N., Karachun, A., Moiseenko, A., Pelipas, Y., Petrov, A., Pravosudov, I., Aiupov, R., Akmalov, Y., Parfenov, A., Suleymanov, N., Tarasov, N., Jumabaev, H., Mamedli, Z., Rasulov, A., Aliev, I., Chernikovskiy, I., Kochnev, V., Komyak, K., Smirnov, A., Achkasov, S., Bolikhov, K., Shelygin, Y., Sushkov, O., Zapolskiy, A., Gvozdenovic, M., Jovanovic, D., Lausevic, Z., Cvetković, D., Maravić, M., Milovanovic, B., Stojakovic, N., Tripković, I., Mihajlovic, D., Nestorovic, M., Pecic, V., Petrovic, D., Stanojevic, G., Barisic, G., Dimitrijevic, I., Krivokapic, Z., Markovic, V., Popovic, M., Aleksic, A., Dabic, D., Kostic, I., Milojkovic, A., Perunicic, V., Lukic, D., Petrovic, T., Radovanovic, D., Radovanovic, Z., Cuk, V. 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R., Sánchez De La Villa, G., Compañ, A., García Marín, A., Nofuentes, C., Orts Micó, F., Pérez Auladell, V., Carrasco, M., Duque Perez, C., Gálvez-Pastor, S., Navarro Garcia, I., Sanchez Perez, A., Enjuto, D., Manuel Bujalance, F., Marcelin, N., Pérez, M., Serrano García, R., Cabrera, A., de la Portilla, F., Diaz-Pavon, J., Jimenez-Rodriguez, R., Vazquez-Monchul, J., Daza González, J., Gómez Pérez, R., Rivera Castellano, J., Roldán de la Rua, J., Errasti Alustiza, J., Fernandez, L., Romeo Ramirez, J., Sardon Ramos, J., Cermeño Toral, B., Alias, D., Garcia-Olmo, D., Guadalajara, H., Herreros, M., Pacheco, P., del Castillo Díez, F., Lima Pinto, F., Martínez Alegre, J., Ortega, I., Picardo Nieto Antonio, A., Caro, A., Escuder, J., Feliu, F., Millan, M., Alos Company, R., Frangi Caregnato, A., Lozoya Trujillo, R., Rodríguez Carrillo, R., Ruiz Carmona, M., Alonso, N., Ambrona Zafra, D., Amilka Ayala Candia, B., Bonnin Pascual, J., Pineño Flores, C., Alcazar Montero, J., Angoso Clavijo, M., Garcia, J., Sanchez Tocino, J., Gómez-Alcazar, C., Costa-Navarro, D., Ferri-Romero, J., Rey-Riveiro, M., Romero-Simó, M., Arencibia, B., Esclapez, P., García-Granero, E., Granero, P., Medina Fernández, F. J., Gallardo Herrera, A. B., Diaz López, C., Navarro Rodriguez, E., Torres Tordera, E., Arenal, J., Citores, M., Marcos, J., Sánchez, J., Tinoco, C., Espin, E., Garcia Granero, A., Jimenez Gomez, L., Sanchez Garcia, J., Vallribera, F., Folkesson, J., Sköldberg, F., Bergman, K., Borgström, E., Frey, J., Silfverberg, A., Söderholm, M., Nygren, J., Segelman, J., Gustafsson, D., Lagerqvist, A., Papp, A., Pelczar, M., Abraham-Nordling, M., Ahlberg, M., Sjovall, A., Tengstrom, J., Hagman, K., Chabok, A., Ezra, E., Nikberg, M., Smedh, K., Tiselius, C., Al-Naimi, N., Dao Duc, M., Meyer, J., Mormont, M., Ris, F., Prevost, G., Villiger, P., Hoffmann, H., Kettelhack, C., Kirchhoff, P., Oertli, D., Weixler, B., Aytac, B., Leventoglu, S., Mentes, B., Yuksel, O., Demirbas, S., Busra Ozkan, B., Selçuk Özbalci, G., Sungurtekin, U., Gülcü, B., Ozturk, E., Yilmazlar, T., Challand, C., Fearnhead, N., Hubbard, R., Kumar, S., Arthur, J., Barben, C., Skaife, P., Slawik, S., Williams, M., Zammit, M., Barker, J., French, J., Sarantitis, I., Slawinski, C., Clifford, R., Eardley, N., Johnson, M., Mcfaul, C., Vimalachandran, D., Allan, S., Bell, A., Oates, E., Shanmugam, V., Brigic, A., Halls, M., Pucher, P., Stubbs, B., Agarwal, T., Chopada, A., Mallappa, S., Pathmarajah, M., Sugden, C., Brown, C., Macdonald, E., Mckay, A., Richards, J., Robertson, A., Kaushal, M., Patel, P., Tezas, S., Touqan, N., Ayaani, S., Marimuthu, K., Piramanayagam, B., Vourvachis, M., Iqbal, N., Korsgen, S., Seretis, C., Shariff, U., Arnold, S., Chan, H., Clark, E., Fernandes, R., Moran, B., Bajwa, A., Mcarthur, D., Cao, K., Cunha, P., Pardoe, H., Quddus, A., Theodoropoulou, K., Bolln, C., Denys, G., Gillespie, M., Manimaran, N., Reidy, J., Malik, A. I., Malik, A., Pitt, J., Aryal, K., El-Hadi, A., Lal, R., Pal, A., Velchuru, V., Oliveira Cunha, M., Thomas, M., Bains, S., Boyle, K., Miller, A., Norwood, M., Yeung, J., Goian, L., Gurjar, S., Saghir, W., Sengupta, N., Stewart-Parker, E., Bailey, S., Khalil, T., Lawes, D., Nikolaou, S., Omar, G., Church, R., Muthiah, B., Garrett, W., Marsh, P., Obeid, N., Chandler, S., Coyne, P., Evans, M., Hunt, L., Lim, J., Oliphant, Z., Papworth, E., Weaver, H., Cuiñas Leon, K., Williams, G., Hernon, J., Kapur, S., Moosvi, R., Shaikh, I., Swafe, L., Aslam, M., Evans, J., Ihedioha, U., Kang, P., Merchant, J., Hompes, R., Middleton, R., Broomfield, A., Crutten-Wood, D., Foster, J., Nash, G., Akhtar, M., Boshnaq, M., Eldesouky, S., Mangam, S., Rabie, M., Ahmed, J., Khan, J., Ming Goh, N., Shamali, A., Stefan, S., Thompson, C., Amin, A., Docherty, J., Lim, M., Walker, K., Watson, A., Hossack, M., Mackenzie, N., Paraoan, M., Alam, N., Daniels, I., Narang, S., Pathak, S., Smart, N., Al-Qaddo, A., Codd, R., Rutka, O., Bronder, C., Crighton, I., Davies, E., Raymond, T., Bookless, L., Griffiths, B., Plusa, S., Carlson, G., Harrison, R., Lees, N., Mason, C., Quayle, J., Branagan, G., Broadhurst, J., Chave, H., Sleight, S., Awad, F., Cruickshank, N., Joy, H., Boereboom, C., Daliya, P., Dhillon, A., Watson, N., Watson, R., Artioukh, D., Gokul, K., Javed, M., Kong, R., Sutton, J., Faiz, O., Jenkins, I., Leo, C. A., Samaranayake, S. F., Warusavitarne, J., Arya, S., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Duff, S., Fatayer, T., Mbuvi, J., Sharma, A., Cornish, J., Davies, L., Harries, R., Morris, C., Torkington, J., Knight, J., Lai, C., Shihab, O., Tzivanakis, A., Hussain, A., Luke, D., Padwick, R., Torrance, A., Tsiamis, A., Dawson, P., Balfour, A., Brady, R., Mander, J., Paterson, H., Chandratreya, N., Chu, H., Cutting, J., Vernon, S., Wai Ho, C., Andreani, S., Patel, H., Warner, M., Yan Qi Tan, J., Iqbal, A., Khan, A., Perrin, K., Raza, A., Tan, S., Meyer, Jérémy, Graduate School, TOBB ETÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, TOBB ETU, Faculty of Medicine, Department of Surgical Sciences, and Demirbaş, Sezai
Subjects: Crohn’s disease, Male, Leak, Surgi-cal technique, anastomotic leak, Bowel anastomosis, colorectal cancer, Crohn's disease, epidemiology, international, oversewn, stapler, surgery, surgical technique, Colorectal cancer, medicine.medical_treatment, 030230 surgery, Colon/surgery, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Epidemiology, Prospective Studies, Treatment Failure, Young adult, Prospective cohort study, Colectomy, Aged, 80 and over, General Surgery/statistics & numerical data, Medical Audit, ddc:617, Anastomosis, Surgical, Gastroenterology, Middle Aged, Colorectal Neoplasms/surgery, Colorectal surgery, 030220 oncology & carcinogenesis, Female, Colectomy/adverse effects, Colorectal Neoplasms, Anastomotic Leak/etiology, Adult, medicine.medical_specialty, Adolescent, Colon, bowel anastomosis, Colorectal Surgery/statistics & numerical data, Anastomosis, NO, Young Adult, 03 medical and health sciences, Surgical Stapling, medicine, Humans, Aged, ta3126, business.industry, Anastomosis, Surgical/adverse effects, Surgical Stapling/adverse effects, Bowel anastomosi, medicine.disease, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], General Surgery, business, Colorectal Surgery
Abstract: AIM: There is little evidence to support choice of technique and configuration for stapled anastomoses after right hemicolectomy and ileocaecal resection. This study aimed to determine the relationship between stapling technique and anastomotic failure.METHOD: Any unit performing gastrointestinal surgery was invited to contribute data on consecutive adult patients undergoing right hemicolectomy or ileocolic resection to this prospective, observational, international, multicentre study. Patients undergoing stapled, side-to-side ileocolic anastomoses were identified and multilevel, multivariable logistic regression analyses were performed to explore factors associated with anastomotic leak.RESULTS: One thousand three hundred and forty-seven patients were included from 200 centres in 32 countries. The overall anastomotic leak rate was 8.3%. Upon multivariate analysis there was no difference in leak rate with use of a cutting stapler for apical closure compared with a noncutting stapler (8.4% vs 8.0%, OR 0.91, 95% CI 0.54-1.53, P = 0.72). Oversewing of the apical staple line, whether in the cutting group (7.9% vs 9.7%, OR 0.87, 95% CI 0.52-1.46, P = 0.60) or noncutting group (8.9% vs 5.7%, OR 1.40, 95% CI 0.46-4.23, P = 0.55) also conferred no benefit in terms of reducing leak rates. Surgeons reporting to be general surgeons had a significantly higher leak rate than those reporting to be colorectal surgeons (12.1% vs 7.3%, OR 1.65, 95% CI 1.04-2.64, P = 0.04).CONCLUSION: This study did not identify any difference in anastomotic leak rates according to the type of stapling device used to close the apical aspect. In addition, oversewing of the anastomotic staple lines appears to confer no benefit in terms of reducing leak rates. Although general surgeons operated on patients with more high-risk characteristics than colorectal surgeons, a higher leak rate for general surgeons which remained after risk adjustment needs further exploration.
Published: 2018
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4. Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy

Author: Careccia, G, Saclier, M, Tirone, M, Ruggieri, E, Principi, E, Raffaghello, L, Torchio, S, Recchia, D, Canepari, M, Gorzanelli, A, Ferrara, M, Castellani, P, Rubartelli, A, Rovere-Querini, P, Casalgrandi, M, Preti, A, Lorenzetti, I, Bruno, C, Bottinelli, R, Brunelli, S, Previtali, S, Bianchi, M, Messina, G, Vénéreau, E, Careccia, Giorgia, Saclier, Marielle, Tirone, Mario, Ruggieri, Elena, Principi, Elisa, Raffaghello, Lizzia, Torchio, Silvia, Recchia, Deborah, Canepari, Monica, Gorzanelli, Andrea, Ferrara, Michele, Castellani, Patrizia, Rubartelli, Anna, Rovere-Querini, Patrizia, Casalgrandi, Maura, Preti, Alessandro, Lorenzetti, Isabella, Bruno, Claudio, Bottinelli, Roberto, Brunelli, Silvia, Previtali, Stefano Carlo, Bianchi, Marco Emilio, Messina, Graziella, Vénéreau, Emilie, Careccia, G, Saclier, M, Tirone, M, Ruggieri, E, Principi, E, Raffaghello, L, Torchio, S, Recchia, D, Canepari, M, Gorzanelli, A, Ferrara, M, Castellani, P, Rubartelli, A, Rovere-Querini, P, Casalgrandi, M, Preti, A, Lorenzetti, I, Bruno, C, Bottinelli, R, Brunelli, S, Previtali, S, Bianchi, M, Messina, G, Vénéreau, E, Careccia, Giorgia, Saclier, Marielle, Tirone, Mario, Ruggieri, Elena, Principi, Elisa, Raffaghello, Lizzia, Torchio, Silvia, Recchia, Deborah, Canepari, Monica, Gorzanelli, Andrea, Ferrara, Michele, Castellani, Patrizia, Rubartelli, Anna, Rovere-Querini, Patrizia, Casalgrandi, Maura, Preti, Alessandro, Lorenzetti, Isabella, Bruno, Claudio, Bottinelli, Roberto, Brunelli, Silvia, Previtali, Stefano Carlo, Bianchi, Marco Emilio, Messina, Graziella, and Vénéreau, Emilie
Abstract: Muscular dystrophies (MDs) are a group of genetic diseases characterized by progressive muscle wasting associated to oxidative stress and persistent inflammation. It is essential to deepen our knowledge on the mechanism connecting these two processes because current treatments for MDs have limited efficacy and/or are associated with side effects. Here, we identified the alarmin high-mobility group box 1 (HMGB1) as a functional link between oxidative stress and inflammation in MDs. The oxidation of HMGB1 cysteines switches its extracellular activities from the orchestration of tissue regeneration to the exacerbation of inflammation. Extracellular HMGB1 is present at high amount and undergoes oxidation in patients with MDs and in mouse models of Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophy 3 (LGMDR3) compared to controls. Genetic ablation of HMGB1 in muscles of DMD mice leads to an amelioration of the dystrophic phenotype as evidenced by the reduced inflammation and muscle degeneration, indicating that HMGB1 oxidation is a detrimental process in MDs. Pharmacological treatment with an engineered nonoxidizable variant of HMGB1, called 3S, improves functional performance, muscle regeneration, and satellite cell engraftment in dystrophic mice while reducing inflammation and fibrosis. Overall, our data demonstrate that the balance between HMGB1 redox isoforms dictates whether skeletal muscle is in an inflamed or regenerating state, and that the nonoxidizable form of HMGB1 is a possible therapeutic approach to counteract the progression of the dystrophic phenotype. Rebalancing the HMGB1 redox isoforms may also be a therapeutic strategy for other disorders characterized by chronic oxidative stress and inflammation.
Published: 2021

5. Patients with Crohn's disease have longer post-operative in-hospital stay than patients with colon cancer but no difference in complications' rate

Author: Dich Grandt, S, El-Hussuna, A, Frasson, M, Singh, B, Gallo, G, Pata, F, Negoi, I, Pinkney, T, Zmora, O, Bhangu, A, Battersby, N, Chaudhri, S, Nepogodiev, D, Vennix, S, Glasbey, J, Minaya, A, Basso, L, Pukuotukai, M, Kelly, Me, Sánchez Guillén, L, Pellino, G, Buchs, N, Morton, D, Bemelman, W, Christensen, P, D'Hoore, A, Laurberg, S, Rubbini, M, Vaizey, C, Magill, L, Perry, R, Sheward, N, Mortensen, Rn, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Salomon, M, Makhmudov, A, Selnyahina, L, Varabei, A, Vizhynis, Y, Claeys, D, Defoort, B, Muysoms, F, Pletinckx, P, Vergucht, V, Debergh, I, Feryn, T, Reusens, H, Francart, D, Jehaes, C, Markiewicz, S, Monami, B, Weerts, J, Bouckaert, W, Houben, B, Knol, J, Sergeant, G, Vangertruyden, G, Haeck, L, Lange, C, Sommeling, C, Vindevoghel, K, Castro, S, De Bruyn, H, Huyghe, M, De Wolf, E, Reynders, D, de Buck van Overstraeten, A, Wolthuis, A, Delibegovic, S, Christiani, A, Marchiori, M Jr, Rocha de Moraes, C, Tercioti, V Jr, Arabadjieva, E, Bulanov, D, Dardanov, D, Stoyanov, V, Yonkov, A, Angelov, K, Maslyankov, S, Sokolov, M, Todorov, G, Toshev, S, Georgiev, Y, Karashmalakov, A, Zafirov, G, Wang, X, Condic, D, Kraljik, D, Mrkovic, H, Pavkovic, V, Raguž, K, Bencurik, V, Holášková, E, Skrovina, M, Farkašová, M, Grolich, T, Kala, Z, Antos, F, Pruchova, V, Sotona, O, Chobola, M, Dusek, T, Ferko, A, Örhalmi, J, Hoch, J, Kocian, P, Martinek, L, Bernstein, I, Gotschalck Sunesen, K, Leunbach, J, Thorlacius-Ussing, O, Uth Oveson, A, Dahl Chirstensen, S, Gamez, V, Oeting, M, Schou Loeve, U, Ugianskis, A, Jessen, M, Krarup, Pm, Linde, K, Mirza, Q, Overgaard Stovring, J, Erritzøe, L, Loft Jakobsen, H, Lykke, J, Palmgren Colov, E, Husted Madsen, A, Linde Friis, T, Amstrup Funder, J, Dich, R, Kjær, S, Rasmussen, S, Schlesinger, N, Dilling Kjaer, M, Qvist, N, Khalid, A, Ali, G, Hadi, S, Rosell Walker, L, Kivelä, A, Lehtonen, T, Lepistö, A, Scheinin, T, Siironen, P, Kössi, J, Kuusanmäki, P, Tomminen, T, Turunen, A, Rautio, T, Vierimaa, M, Huhtinen, H, Karvonen, J, Lavonius, M, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Kepenekian, V, Passot, G, Maggiori, L, Manceau, G, Panis, Y, Gout, M, Rullier, E, van Geluwe, B, Chafai, N, Lefevre, Jh, Parc, Y, Tiret, E, Couette, C, Duchalais, E, Agha, A, Hornberger, M, Hungbauer, A, Iesalnieks, I, Weindl, I, Crescenti, F, Keller, M, Kolodziejski, N, Scherer, R, Sterzing, D, Bock, B, Boehm, G, El-Magd, M, Krones, C, Niewiera, M, Buhr, J, Cordesmeyer, S, Hoffmann, M, Krückemeier, K, Vogel, T, Schön, M, Baral, J, Lukoschek, T, Münch, S, Pullig, F, Horisberger, K, Kienle, P, Magdeburg, J, Post, S, Batzalexis, K, Germanos, S, Agalianos, C, Dervenis, C, Gouvas, N, Kanavidis, P, Kottikias, A, Katsoulis, Ie, Korkolis, D, Plataniotis, G, Sakorafas, G, Akrida, I, Argentou, M, Kollatos, C, Lampropoulos, C, Tsochatzis, S, Besznyák, I, Bursics, A, Egyed, T, Papp, G, Svastics, I, Atladottir, J, Möller, P, Sigurdsson, H, Stefánsson, T, Valsdottir, E, Andrews, E, Foley, N, Hechtl, D, Majeed, M, Mccourt, M, Hanly, A, Hyland, J, Martin, S, O'Connell, Pr, Winter, D, Connelly, T, Joyce, W, Wrafter, P, Berkovitz, R, Avital, S, Haj Yahia, I, Hermann, N, Shpitz, B, White, I, Lishtzinsky, Y, Tsherniak, A, Wasserberg, N, Horesh, N, Keler, U, Pery, R, Shapiro, R, Tulchinsky, H, Badran, B, Dayan, K, Iskhakov, A, Lecaros, J, Nabih, N, Angrima, I, Bardini, R, Pizzolato, E, Tonello, M, Arces, F, Balestri, R, Ceccarelli, C, Prosperi, V, Rossi, E, Giannini, I, Vincenti, L, Di Candido, F, Di Iena, M, Guglielmi, A, Caputi-Iambrenghi, O, Marsanic, P, Mellano, A, Muratore, A, Annecchiarico, M, Bencini, L, Amore Bonapasta, S, Coratti, A, Guerra, F, Asteria, Cr, Boccia, L, Gerard, L, Pascariello, A, Manca, G, Marino, F, Casaril, A, Inama, M, Moretto, G, Bacchelli, C, Carvello, M, Mariani, N, Montorsi, M, Spinelli, A, Romairone, E, Scabini, S, Belli, A, Bianco, F, De Franciscis, S, Maria Romano, G, Delrio, P, Pace, U, Rega, D, Sassaroli, C, Scala, D, De Luca, R, Ruggieri, E, Elbetti, C, Garzi, A, Romoli, L, Scatizzi, M, Vannucchi, A, Curletti, G, Durante, V, Galleano, R, Mariani, F, Reggiani, L, Bellomo, R, Infantino, A, Franceschilli, L, Sileri, P, Clementi, I, Coletta, D, La Torre, F, Mingoli, A, Velluti, F, Di Giacomo, A, Fiorot, A, Massani, M, Padoan, L, Ruffolo, C, Caruso, S, Franceschini, F, Laessig, R, Monaci, I, Rontini, M, De Nardi, P, Elmore, U, Lemma, M, Rosati, R, Tamburini, A, De Luca, M, Sartori, A, Benevento, A, Bottini, C, Ferrari, Cc, Tessera, G, Selvaggi, F, Lanzani, A, Romano, F, Sgroi, G, Steccanella, F, Turati, L, Yamamoto, T, Ancans, G, Gerkis, S, Leja, M, Pcolkins, A, Sivins, A, Latkauskas, T, Lizdenis, P, Saladžinskas, Ž, Švagždys, S, Tamelis, A, Razbadauskas, A, Sokolovas, M, Dulskas, A, Samalavicius, N, Jotautas, V, Mikalauskas, S, Poskus, E, Poskus, T, Strupas, K, Camenzuli, C, Cini, C, Predrag, A, Psaila, J, Spiteri, N, Buskens, C, de Groof EJ, Gooszen, J, Tanis, P, Belgers, E, Davids, P, Furnee, E, Postma, E, Pronk, A, Smakman, N, Clermonts, S, Zimmerman, D, Omloo, J, van der Zaag, E, van Duijvendijk, P, Wassenaar, E, Bruijninckx, M, de Graff, E, Doornebosch, P, Tetteroo, G, Vermaas, M, Iordens, G, Knops, S, Toorenvliet, B, van Westereenen HL, Boerma, E, Coene, P, van der Harst, E, Van Der Pool, A, Raber, M, Melenhorst, J, de Castro, S, Gerhards, M, Arron, M, Bremers, A, de Wilt, H, Ferenschild, F, Yauw, S, Cense, H, Demirkiran, A, Hunfeld, M, Mulder, I, Nonner, J, Swank, H, van Wagensveld, B, Bolmers, M, Briel, J, van Geloven, A, Echazarreta-Gallego, E, Elia-Guedea, M, Ramirez, J, van Rossem, C, Klemann, V, Konsten, J, Leenders, B, Schok, T, Bleeker, W, Gidwani, A, Lawther, R, Loughlin, P, Skelly, B, Spence, R, Brun, M, Helgeland, M, Ignjatovic, D, Øresland, T, Yousefi, P, Flåten Backe, I, Helmer Sjo, O, Nesbakken, A, Tandberg Eriksen, M, Cais, A, Hallvard Træland, J, Herikstad, R, Kørner, H, Lauvland, N, Jajtner, D, Kabiesz, W, Rak, M, Gmerek, L, Horbacka, K, Horst, N, Krokowicz, P, Kwiatkowski, A, Pasnik, K, Karcz, P, Romaniszyn, M, Rusek, T, Walega, P, Czarencki, R, Obuszko, Z, Sitarska, M, Wojciech, W, Zawadzki, M, Amado, S, Clara, P, Couceiro, A, Malaquias, R, Rama, N, Almeida, A, Barbosa, E, Cernadas, E, Duarte, A, Silva, P, Costa, S, Martinez Insua, C, Pereira, J, Pereira, C, Sacchetti, M, Carvalho Pinto, B, Jorge Vieira Sousa, P, Marques, R, Oliveira, A, Cardoso, R, Carlos, S, Corte-Real, J, Moniz Pereira, P, Souto, R, Carneiro, C, Marinho, R, Nunes, V, Rocha, R, Sousa, M, Leite, J, Melo, F, Pimentel, J, Ventura, L, Vila Nova, C, Copăescu, C, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Domansky, N, Karachun, A, Moiseenko, A, Pelipas, Y, Petrov, A, Pravosudov, I, Aiupov, R, Akmalov, Y, Parfenov, A, Suleymanov, N, Tarasov, N, Jumabaev, H, Mamedli, Z, Rasulov, A, Aliev, I, Chernikovskiy, I, Kochnev, V, Komyak, K, Smirnov, A, Achkasov, S, Bolikhov, K, Shelygin, Y, Sushkov, O, Zapolskiy, A, Gvozdenovic, M, Jovanovic, D, Lausevic, Z, Cvetković, D, Maravić, M, Milovanovic, B, Stojakovic, N, Tripković, I, Mihajlovic, D, Nestorovic, M, Pecic, V, Petrovic, D, Stanojevic, G, Barisic, G, Dimitrijevic, I, Krivokapic, Z, Markovic, V, Popovic, M, Aleksic, A, Dabic, D, Kostic, I, Milojkovic, A, Perunicic, V, Lukic, D, Petrovic, T, Radovanovic, D, Radovanovic, Z, Cuk, Vm, Cuk, Vv, Kenic, M, Kovacevic, B, Krdzic, I, Korcek, J, Rems, M, Toplak, J, Escarrâ, J, Gil Barrionuevo, M, Golda, T, Kreisler Moreno, E, Zerpa Martin, C, Álvarez Laso, C, Cumplido, P, Padin, H, Baixauli Fons, J, Hernández Lizoain, J, Martinez Ortega, P, Molina Fernández, M, Sánchez Justicia, C, Antonio Gracia Solanas, J, Córdoba Díaz de Laspra, E, Arredondo Chaves, J, Diez González, P, Elosua, T, Sahagún, J, Turienzo Frade, A, Álvarez Conde, J, Castrillo, E, Diaz Maag, R, Maderuelo, V, Saldarriaga, L, Aldrey Cao, I, Fernández Varela, X, Núñez Fernández, S, Parajó Calvo, A, Villar Álvarez, S, Blesa Sierra, I, Lozano, R, Márquez, M, Porcel, O, Menendez, P, Fernández Hevia, M, Flores Sigüenza, L, Jimenez Toscano, M, Lacy Fortuny, A, Ordoñez, J, Espi, A, Garcia Botello, S, Martín Arévalo, J, Moro Valdezate, D, Pla, M, Blanco Antona, F, Abrisqueta, J, Ibañez Canovas, N, Lujan Mompean, J, Escolá Ripoll, D, Martinez Gonzalez, S, Parodi, J, Fernández López, A, Ramos Fernández, M, Castellvi Valls, J, Ortiz de Zarate, L, Ribas, R, Sabia, D, Viso, L, Alonso Gonçalves, S, José Gil, M, Pascual Damieta, M, Pera, M, Salvans Ruiz, S, Bernal, J, Landete, F, Ais, G, Etreros, J, Aguiló Lucia, J, Boscá, A, Deusa, S, García Del Caño, J, Viciano, V, García Armengol, J, Roig, J, Blas, J, Escartin, J, Fatás, J, Fernando, J, Ferrer, R, Arias Pacheco, R, García Flórez, L, Moreno Gijón, M, Otero Díez, J, Solar Garcia, L, Aguilar Teixido, F, Balaguer Ojo, C, Bargallo Berzosa, J, Lamas Moure, S, Enrique Sierra, J, Fermiñán, A, Herrerias, F, Rufas, M, Viñas, J, Codina Cazador, A, Farrés, R, Gómez, N, Julià, D, Planellas, P, López, J, Luna, A, Maristany, C, Muñoz Duyos, A, Puértolas, N, Alcantara Moral, M, Serra Aracil, X, Concheiro Coello, P, Gómez, D, Carton, C, Miguel, A, Reoyo Pascual, F, Valero Cerrato, X, Zambrano Muñoz, R, Cervera Aldama, J, García González, J, Ramos Prada, J, Santamaría Olabarrieta, M, Urigüen Echeverría, A, Coves Alcover, R, Espinosa Soria, J, Fernandez Rodriguez, E, Hernandis Villalba, J, Maturana Ibañez, V, De la Torre Gonzalez, F, Huerga, D, Pérez Viejo, E, Rivera, A, Ruiz Ucar, E, Garcia Septiem, J, Jiménez, V, Jiménez Miramón, J, Ramons Rodriquez, J, Rodriguez Alvarez, V, Garcea, A, Ponchietti, L, Borda, N, Enriquez Navascues, J, Saralegui, Y, Febles Molina, G, Nogues, E, Rodríguez, M, Roque Castellano, C, Sosa Quesada, Y, Alvarez Gallego, M, Pascual, I, Rubio Perez, I, Diaz San Andrés, B, Tone Villanueva, F, Alonso, J, Cagigas, C, Castillo, J, Gómez, M, Martín Parra, J, Mengual Ballester, M, Pellicer Franco, E, Soria Aledo, V, Valero Navarro, G, Caballero Rodríguez, E, Gonzalez De Chaves, P, Hernandez, G, Perez Alvarez, A, 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Malik, A, Pitt, J, Aryal, K, El Hadi, A, Lal, R, Pal, A, Velchuru, V, Oliveira Cunha, M, Thomas, M, Bains, S, Boyle, K, Miller, A, Norwood, M, Yeung, J, Goian, L, Gurjar, S, Saghir, W, Sengupta, N, Stewart Parker, E, Bailey, S, Khalil, T, Lawes, D, Nikolaou, S, Omar, G, Church, R, Muthiah, B, Garrett, W, Marsh, P, Obeid, N, Chandler, S, Coyne, P, Evans, M, Hunt, L, Lim, J, Oliphant, Z, Papworth, E, Weaver, H, Cuiñas Leon, K, Williams, G, Hernon, J, Kapur, S, Moosvi, R, Shaikh, I, Swafe, L, Aslam, M, Evans, J, Ihedioha, U, Kang, P, Merchant, J, Hompes, R, Middleton, R, Broomfield, A, Crutten Wood, D, Foster, J, Nash, G, Akhtar, M, Boshnaq, M, Eldesouky, S, Mangam, S, Rabie, M, Ahmed, J, Khan, J, Ming Goh, N, Shamali, A, Stefan, S, Thompson, C, Amin, A, Docherty, J, Lim, M, Walker, K, Watson, A, Hossack, M, Mackenzie, N, Paraoan, M, Alam, N, Daniels, I, Narang, S, Pathak, S, Smart, N, Al Qaddo, A, Codd, R, Rutka, O, Bronder, C, Crighton, I, Davies, E, Raymond, T, Bookless, L, Griffiths, B, Plusa, S, Carlson, G, Harrison, R, Lees, N, Mason, C, Quayle, J, Branagan, G, Broadhurst, J, Chave, H, Sleight, S, Awad, F, Cruickshank, N, Joy, H, Boereboom, C, Daliya, P, Dhillon, A, Watson, N, Watson, R, Artioukh, D, Gokul, K, Javed, M, Kong, R, Sutton, J, Faiz, O, Jenkins, I, Leo, Ca, Samaranayake, Sf, Warusavitarne, J, Arya, S, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Duff, S, Fatayer, T, Mbuvi, J, Sharma, A, Cornish, J, Davies, L, Harries, R, Morris, C, Torkington, J, Knight, J, Lai, C, Shihab, O, Tzivanakis, A, Hussain, A, Luke, D, Padwick, R, Torrance, A, Tsiamis, A, Dawson, P, Balfour, A, Brady, R, Mander, J, Paterson, H, Chandratreya, N, Chu, H, Cutting, J, Vernon, S, Wai Ho, C, Andreani, S, Patel, H, Warner, M, Tan, Yq, Iqbal, A, Khan, A, Perrin, K, Raza, A, and S Tan, And
Subjects: Crohn’s disease, medicine.medical_specialty, Complications, Colorectal cancer, SURGERY, medicine.medical_treatment, Bowel resection, Disease, Inflammatory bowel disease, NO, COLORECTAL-CANCER, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], MORBIDITY, 0302 clinical medicine, Medicine, Crohn’s disease, Colon cancer, Complications, Length of stay, Bowel resection, Right hemicolectomy, DIVERTICULAR-DISEASE, Colon cancer, Length of stay, Right hemicolectomy, colon cancer, complications, length of stay, bowel resection, right hemicolectomy, PREOPERATIVE OPTIMIZATION, RISK, Crohn's disease, ddc:617, business.industry, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, digestive system diseases, Surgery, 030220 oncology & carcinogenesis, 3121 General medicine, internal medicine and other clinical medicine, Diverticular disease, Prospective Study, 030211 gastroenterology & hepatology, SMOKING, business, Complication, Hospital stay, INFLAMMATORY-BOWEL-DISEASE
Abstract: BACKGROUND: Right hemicolectomy or ileocecal resection are used to treat benign conditions like Crohn's disease (CD) and malignant ones like colon cancer (CC).AIM: To investigate differences in pre- and peri-operative factors and their impact on post-operative outcome in patients with CC and CD.METHODS: This is a sub-group analysis of the European Society of Coloproctology's prospective, multi-centre snapshot audit. Adult patients with CC and CD undergoing right hemicolectomy or ileocecal resection were included. Primary outcome measure was 30-d post-operative complications. Secondary outcome measures were post-operative length of stay (LOS) at and readmission.RESULTS: Three hundred and seventy-five patients with CD and 2,515 patients with CC were included. Patients with CD were younger (median = 37 years for CD and 71 years for CC (P < 0.01), had lower American Society of Anesthesiology score (ASA) grade (P < 0.01) and less comorbidity (P < 0.01), but were more likely to be current smokers (P < 0.01). Patients with CD were more frequently operated on by colorectal surgeons (P < 0.01) and frequently underwent ileocecal resection (P < 0.01) with higher rate of de-functioning/primary stoma construction (P < 0.01). Thirty-day post-operative mortality occurred exclusively in the CC group (66/2515, 2.3%). In multivariate analyses, the risk of post-operative complications was similar in the two groups (OR 0.80, 95%CI: 0.54-1.17; P = 0.25). Patients with CD had a significantly longer LOS (Geometric mean 0.87, 95%CI: 0.79-0.95; P < 0.01). There was no difference in re-admission rates. The audit did not collect data on post-operative enhanced recovery protocols that are implemented in the different participating centers.CONCLUSION: Patients with CD were younger, with lower ASA grade, less comorbidity, operated on by experienced surgeons and underwent less radical resection but had a longer LOS than patients with CC although complications' rate was not different between the two groups.
Published: 2019
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6. Predictors for Anastomotic Leak, Postoperative Complications, and Mortality After Right Colectomy for Cancer: Results From an International Snapshot Audit

Author: Gallo, G., Pata, F., Vennix, S., Laurberg, S., Morton, D., Rubbini, M., Vaizey, C., Magill, L., Perry, R., Sheward, N., Hervas, D., Cillo, M., Estefania, D., Uriburu, J.P., Ruiz, H., Solomon, M., Makhmudov, A., Selnyahina, L., Varabei, A., Vizhynis, Y., Claeys, D., Defoort, B., Muysoms, F., Pletinckx, P., Vergucht, V., Debergh, I., Feryn, T., Reusens, H., Nachtergaele, M., Francart, D., Jehaes, C., Markiewicz, S., Monami, B., Weerts, J., Houben, B., Haeck, L., Lange, C., Sommeling, C., Vindevoghel, K., Castro, S., De Bruyn, H., Huyghe, M., De Wolf, E., Reynders, D., D'Hoore, A., De Buck Van Overstraeten, A., Wolthuis, A., Delibegovic, S., Christiani, A., Marchiori, M., Jr., De Moraes, C.R., Tercioti, V., Jr., Arabadjieva, E., Bulanov, D., Dardanov, D., Stoyanov, V., Yonkov, A., Angelov, K., Maslyankov, S., Sokolov, M., Todorov, G., Toshev, S., Georgiev, Y., Karashmalakov, A., Zafirov, G., Wang, X., Condic, D., Kraljik, D., Mrkovic, H., Pavkovic, V., Raguž, K., Bencurik, V., Holášková, E., Skrovina, M., Farkašová, M., Grolich, T., Kala, Z., Antos, F., Pruchova, V., Sotona, O., Chobola, M., Dusek, T., Ferko, A., Örhalmi, J., Hoch, J., Kocian, P., Martinek, L., Bernstein, I., Sunesen, K.G., Leunbach, J., Thorlacius-Ussing, O., Oveson, A.U., Christensen, P., Chirstensen, S.D., Gamez, V., Oeting, M., Loeve, U.S., Ugianskis, A., Jessen, M., Krarup, P., Linde, K., Mirza, Q., Stovring, J.O., Erritzøe, L., Jakobsen, H.L., Lykke, J., Colov, E.P., Madsen, A.H., Friis, T.L., Funder, J.A., Dich, R., Kjar, S., Rasmussen, S., Schlesinger, N., Kjaer, M.D., Qvist, N., Khalid, A., Ali, G., El-Hussuna, A., Hadi, S., Walker, L.R., Kivelä, A., Lehtonen, T., Lepistö, A., Scheinin, T., Siironen, P., Kössi, J., Kuusanmäki, P., Tomminen, T., Turunen, A., Rautio, T., Vierimaa, M., Huhtinen, H., Karvonen, J., Lavonius, M., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Kepenekian, V., Passot, G., Maggiori, L., Manceau, G., Panis, Y., Gout, M., Rullier, E., Van Geluwe, 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B., Garrett, W., Marsh, P., Obeid, N., Chandler, S., Coyne, P., Evans, M., Hunt, L., Lim, J., Oliphant, Z., Papworth, E., Weaver, H., Leon, K.C., Williams, G., Hernon, J., Kapur, S., Moosvi, R., Shaikh, I., Swafe, L., Aslam, M., Evans, J., Ihedioha, U., Kang, P., Merchant, J., Hompes, R., Middleton, R., Broomfield, A., Crutten-Wood, D., Foster, J., Nash, G., Akhtar, M., Boshnaq, M., Eldesouky, S., Mangam, S., Rabie, M., Ahmed, J., Khan, J., Goh, N.M., Shamali, A., Stefan, S., Nepogodiev, D., Pinkney, T.D., Thompson, C., Amin, A., Docherty, J., Lim, M., Walker, K., Watson, A., Hossack, M., Mackenzie, N., Paraoan, M., Alam, N., Daniels, I., Narang, S., Pathak, S., Smart, N., Al-Qaddo, A., Codd, R., Rutka, O., Bronder, C., Crighton, I., Davies, E., Raymond, T., Bookless, L., Griffiths, B., Plusa, S., Carlson, G., Harrison, R., Lees, N., Mason, C., Quayle, J., Branagan, G., Broadhurst, J., Chave, H., Sleight, S., Awad, F., Bhangu, A., Cruickshank, N., Joy, H., Boereboom, C., Daliya, P., Dhillon, A., Watson, N., Watson, R., Artioukh, D., Gokul, K., Javed, M., Kong, R., Sutton, J., Faiz, O., Jenkins, I., Leo, C., Samaranayake, F., Warusavitarne, J., Arya, S., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Duff, S., Fatayer, T., Mbuvi, J., Sharma, A., Cornish, J., Davies, L., Harries, R., Morris, C., Torkington, J., Knight, J., Lai, C., Shihab, O., Tzivanakis, A., Hussain, A., Luke, D., Padwick, R., Torrance, A., Tsiamis, A., Dawson, P., Balfour, A., Brady, R., Mander, J., Paterson, H., Chandratreya, N., Chu, H., Cutting, J., Vernon, S., Ho, C.W., Andreani, S., Patel, H., Warner, M., Tan, J.Y.Q., Iqbal, A., Khan, A., Perrin, K., Raza, A., Tan, S., European Society of Coloproctology Collaborating Group Collaborators, Group, ESCP Cohort Studies Sub-Committee, ESCP Research Committee, Logistical Support and Data Collection, Analysis, Investigators, Radiology and nuclear medicine, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, MUMC+: MA Heelkunde (9), Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Neurology, and Center for Evidence Based Education
Subjects: Male, Leak, Conference Paper, adverse event, ileostomy, non-smoker, 0302 clinical medicine, middle aged, antibiotic therapy, 80 and over, antibiotic agent, postoperative complication, emergency surgery, Colectomy, cecum, Aged, 80 and over, OUTCOMES, adult, COLON-CANCER, Gastroenterology, operation duration, clinical trial, General Medicine, cohort analysis, laparoscopic surgery, ureter injury, Survival Rate, aged, risk factor, 030220 oncology & carcinogenesis, Cohort, kidney injury, 030211 gastroenterology & hepatology, Colonic Neoplasms/mortality, anastomosis leakage, liver injury, prospective study, medicine.medical_specialty, SURGICAL STRESS, ELECTIVE RIGHT, surgical infection, 03 medical and health sciences, Humans, human, Aged, clinical audit, sex ratio, major clinical study, mortality, hemicolectomy, multicenter study, RISK-FACTORS, observational study, Complication, Anastomotic leak, Colon cancer, Postoperative outcome, Right colectomy, general surgery, surgical mortality, SURGERY, very elderly, morbidity, Anastomotic Leak, mortality rate, open surgery, Cohort Studies, Postoperative Complications, gallbladder disease, LAPAROSCOPY, Risk Factors, Neoplasms, cancer mortality, Laparoscopy, Prospective cohort study, colon resection, Medical Audit, medicine.diagnostic_test, Mortality rate, colon tumor, Middle Aged, female, colon cancer, Right Colectomy, Colonic Neoplasms, ileum, surgical stapling, Female, cancer surgery, Colectomy/adverse effects, duodenum injury, small intestine resection, RESECTION, reoperation, Anastomosis, NO, MORBIDITY, medicine, operative blood loss, LS7_4, percutaneous drainage, business.industry, suture technique, Surgery, blood vessel injury, peroperative complication, elective surgery, Anastomotic Leak/epidemiology, pathology, business
Abstract: A right hemicolectomy is among the most commonly performed operations for colon cancer, but modern high-quality, multination data addressing the morbidity and mortality rates are lacking.This study reports the morbidity and mortality rates for right-sided colon cancer and identifies predictors for unfavorable short-term outcome after right hemicolectomy.This was a snapshot observational prospective study.The study was conducted as a multicenter international study.The 2015 European Society of Coloproctology snapshot study was a prospective multicenter international series that included all patients undergoing elective or emergency right hemicolectomy or ileocecal resection over a 2-month period in early 2015. This is a subanalysis of the colon cancer cohort of patients.Predictors for anastomotic leak and 30-day postoperative morbidity and mortality were assessed using multivariable mixed-effect logistic regression models after variables selection with the Lasso method.Of the 2515 included patients, an anastomosis was performed in 97.2% (n = 2444), handsewn in 38.5% (n = 940) and stapled in 61.5% (n = 1504) cases. The overall anastomotic leak rate was 7.4% (180/2444), 30-day morbidity was 38.0% (n = 956), and mortality was 2.6% (n = 66). Patients with anastomotic leak had a significantly increased mortality rate (10.6% vs 1.6% no-leak patients; p0.001). At multivariable analysis the following variables were associated with anastomotic leak: longer duration of surgery (OR = 1.007 per min; p = 0.0037), open approach (OR = 1.9; p = 0.0037), and stapled anastomosis (OR = 1.5; p = 0.041).This is an observational study, and therefore selection bias could be present. For this reason, a multivariable logistic regression model was performed, trying to correct possible confounding factors.Anastomotic leak after oncologic right hemicolectomy is a frequent complication, and it is associated with increased mortality. The key contributing surgical factors for anastomotic leak were anastomotic technique, surgical approach, and duration of surgery. See Video Abstract at http://links.lww.com/DCR/B165. PREDICTORES DE FUGA ANASTOMóTICA, COMPLICACIONES POSTOPERATORIAS Y MORTALIDAD DESPUéS DE LA COLECTOMíA DERECHA POR CáNCER: RESULTADOS DE UNA AUDITORíA INTERNACIONAL DE CORTO PLAZO: La hemicolectomía derecha se encuentra entre las operaciones más frecuentemente realizadas para cáncer de colon, pero faltan datos modernos multinacionales de alta calidad, que aborden las tasas de morbilidad y mortalidad.Reportar la tasa de morbilidad y mortalidad para cáncer de colon del lado derecho, e identificar predictores de resultados desfavorables a corto plazo, después de la hemicolectomía derecha.Estudio prospectivo observacional de corto plazo.Estudio multicéntrico internacional.El estudio de corto plazo de la Sociedad Europea de Coloproctología de 2015, fue una serie prospectiva multicéntrica internacional, que incluyó a todos los pacientes sometidos a hemicolectomía derecha electiva, de emergencia o resección ileocecal, por un período de dos meses y a principios de 2015. Este es un subanálisis, cohorte de pacientes con cáncer de colon.Los predictores de fuga anastomótica, morbilidad y mortalidad postoperatorias a los 30 días, se evaluaron usando modelos de regresión logística de efectos multivariables mixtos, después de la selección de variables con el método Lasso.De los 2,515 pacientes incluidos, se realizó una anastomosis en el 97,2% (n = 2,444); sutura manual en 38.5% (n = 940) y por engrapadora en 61.5% (n = 1504) casos. La tasa global de fuga anastomótica fue del 7,4% (180/2,444), morbilidad a los 30 días fue del 38,0% (n = 956) y la mortalidad fue del 2,6% (n = 66). Los pacientes con fuga anastomótica tuvieron una tasa de mortalidad significativamente mayor (10,6% frente al 1,6% de pacientes sin fuga, p0,001). En el análisis multivariable, las siguientes variables se asociaron con la fuga anastomótica: mayor duración de la cirugía (OR 1.007 por minuto, p = 0.0037), abordaje abierto (OR 1.9, p = 0.0037) y anastomosis por engrapadora (OR 1.5, p = 0.041).Este es un estudio observacional y por lo tanto podría estar presente el sesgo de selección. Por esta razón, se realizó un modelo de regresión logística multivariable, tratando de corregir posibles factores de confusión.La fuga anastomótica después de la hemicolectomía derecha oncológica, es una complicación frecuente y asociada a mayor mortalidad. Los factores quirúrgicos clave que contribuyeron a la fuga anastomótica, fueron la técnica anastomótica, abordaje quirúrgico y duración de la cirugía. Consulte Video Resumen en http://links.lww.com/DCR/B165. (Traducción-Dr. Fidel Ruiz Healy).
Published: 2020
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7. Laparoscopic spleen-preserving distal pancreatectomy with splenic vessels preservation for pNET in a young patient

Author: De Luca, R., primary, Barile, G., additional, Cartanese, C., additional, Grasso, E., additional, Lomonaco, R., additional, Rucci, A., additional, Ruggieri, E., additional, and Simone, M., additional
Published: 2021
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8. Risk factors for unfavourable postoperative outcome in patients with Crohn's disease undergoing right hemicolectomy or ileocaecal resection. An international audit by ESCP and S-ECCO

Author: El-Hussuna, A., Pinkney, T., Zmora, O., Frasson, M., Bhangu, A., Battersby, N., Chaudhri, S., Nepogodiev, D., Singh, B., Vennix, S., Altomare, D., Bemelman, W., Christensen, P., D'Hoore, A., Laurberg, S., Morton, D., Rubbini, M., Vaizey, C., Magill, L., Perry, R., Sheward, N., Nørmark Mortensen, Rikke, El-Hussuna, Alaa, Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Salomon, M., Makhmudov, A., Selnyahina, L., Varabei, A., Vizhynis, Y., Claeys, D., Defoort, B., Muysoms, F., Pletinckx, P., Vergucht, V., Debergh, I., Feryn, T., Reusens, H., Nachtergaele, M., Francart, D., Jehaes, C., Markiewicz, S., Monami, B., Weerts, J., Bouckaert, W., Houben, B., Knol, J., Sergeant, G., Vangertruyden, G., Haeck, L., Lange, C., Sommeling, C., Vindevoghel, K., Castro, S., De Bruyn, H., Huyghe, M., De Wolf, E., Reynders, D., de Buck van Overstraeten, A., Wolthuis, A., Delibegovic, S., Christiani, A., Marchiori, M., Rocha de Moraes, C., Tercioti, V., Arabadjieva, E., Bulanov, D., Dardanov, D., Stoyanov, V., Yonkov, A., Angelov, K., Maslyankov, S., Sokolov, M., Todorov, G., Toshev, S., Georgiev, Y., Karashmalakov, A., Zafirov, G., Wang, X., Condic, D., Kraljik, D., Mrkovic, H., Pavkovic, V., Raguž, K., Bencurik, V., Holášková, E., Skrovina, M., Farkašová, M., Grolich, T., Kala, Z., Antos, F., Pruchova, V., Sotona, O., Chobola, M., Dusek, T., Ferko, A., Örhalmi, J., Hoch, J., Kocian, P., Martinek, L., Bernstein, I., Gotschalck Sunesen, K., Leunbach, J., Thorlacius-Ussing, O., Uth Oveson, A., Dahl Chirstensen, S., Gamez, V., Oeting, M., Schou Loeve, U., Ugianskis, A., Jessen, M., Krarup, P. M., Linde, K., Mirza, Q., Overgaard Stovring, J., Erritzøe, L., Loft Jakobsen, H., Lykke, J., Palmgren Colov, E., Husted Madsen, A., Linde Friis, T., Amstrup Funder, J., Dich, R., Kjær, S., Rasmussen, S., Schlesinger, N., Dilling Kjaer, M., Qvist, N., Khalid, A., Ali, G., Hadi, S., Rosell Walker, L., Kivelä, A., Lehtonen, T., Lepistö, A., Scheinin, T., Siironen, P., Kössi, J., Kuusanmäki, P., Tomminen, T., Turunen, A., Rautio, T., Vierimaa, M., Huhtinen, H., Karvonen, J., Lavonius, M., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Kepenekian, V., Passot, G., Maggiori, L., Manceau, G., Panis, Y., Gout, M., Rullier, E., van Geluwe, B., Chafai, N., Lefevre, J. H., Parc, Y., Tiret, E., Couette, C., Duchalais, E., Agha, A., Hornberger, M., Hungbauer, A., Iesalnieks, I., Weindl, I., Crescenti, F., Keller, M., Kolodziejski, N., Scherer, R., Sterzing, D., Bock, B., Boehm, G., El-Magd, M., Krones, C., Niewiera, M., Buhr, J., Cordesmeyer, S., Hoffmann, M., Krückemeier, K., Vogel, T., Schön, M., Baral, J., Lukoschek, T., Münch, S., Pullig, F., Horisberger, K., Kienle, P., Magdeburg, J., Post, S., Batzalexis, K., Germanos, S., Agalianos, C., Dervenis, C., Gouvas, N., Kanavidis, P., Kottikias, A., Katsoulis, I. E., Korkolis, D., Plataniotis, G., Sakorafas, G., Akrida, I., Argentou, M., Kollatos, C., Lampropoulos, C., Tsochatzis, S., Besznyák, I., Bursics, A., Egyed, T., Papp, G., Svastics, I., Atladottir, J., Möller, P., Sigurdsson, H., Stefánsson, T., Valsdottir, E., Andrews, E., Foley, N., Hechtl, D., Majeed, M., Mccourt, M., Hanly, A., Hyland, J., Martin, S., O'Connell, P. 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C., Pata, F., Tessera, G., Pellino, G., Selvaggi, F., Lanzani, A., Romano, F., Sgroi, G., Steccanella, F., Turati, L., Yamamoto, T., Ancans, G., Gerkis, S., Leja, M., Pcolkins, A., Sivins, A., Latkauskas, T., Lizdenis, P., Saladžinskas, Å½., Švagždys, S., Tamelis, A., Razbadauskas, A., Sokolovas, M., Dulskas, A., Samalavicius, N., Jotautas, V., Mikalauskas, S., Poskus, E., Poskus, T., Strupas, K., Camenzuli, C., Cini, C., Predrag, A., Psaila, J., Spiteri, N., Buskens, C., de Groof, E. J., Gooszen, J., Tanis, P., Belgers, E., Davids, P., Furnee, E., Postma, E., Pronk, A., Smakman, N., Clermonts, S., Zimmerman, D., Omloo, J., van der Zaag, E., van Duijvendijk, P., Wassenaar, E., Bruijninckx, M., de Graff, E., Doornebosch, P., Tetteroo, G., Vermaas, M., Iordens, G., Knops, S., Toorenvliet, B., van Westereenen, H. L., Boerma, E., Coene, P., van der Harst, E., Van Der Pool, A., Raber, M., Melenhorst, J., de Castro, S., Gerhards, M., Arron, M., Bremers, A., de Wilt, H., Ferenschild, F., Yauw, S., Cense, H., Demirkiran, A., Hunfeld, M., Mulder, I., Nonner, J., Swank, H., van Wagensveld, B., Bolmers, M., Briel, J., van Geloven, A., van Rossem, C., Klemann, V., Konsten, J., Leenders, B., Schok, T., Bleeker, W., Gidwani, A., Lawther, R., Loughlin, P., Skelly, B., Spence, R., Brun, M., Helgeland, M., Ignjatovic, D., Øresland, T., Yousefi, P., Flåten Backe, I., Helmer Sjo, O., Nesbakken, A., Tandberg-Eriksen, M., Cais, A., Hallvard Træland, J., Herikstad, R., Kørner, H., Lauvland, N., Jajtner, D., Kabiesz, W., Rak, M., Gmerek, L., Horbacka, K., Horst, N., Krokowicz, P., Kwiatkowski, A., Pasnik, K., Karcz, P., Romaniszyn, M., Rusek, T., Walega, P., Czarencki, R., Obuszko, Z., Sitarska, M., Wojciech, W., Zawadzki, M., Amado, S., Clara, P., Couceiro, A., Malaquias, R., Rama, N., Almeida, A., Barbosa, E., Cernadas, E., Duarte, A., Silva, P., Costa, S., Martinez Insua, C., Pereira, J., Pereira, C., Sacchetti, M., Carvalho Pinto, B., Jorge Vieira Sousa, P., Marques, R., Oliveira, A., Cardoso, R., Carlos, S., Corte-Real, J., Moniz Pereira, P., Souto, R., Carneiro, C., Marinho, R., Nunes, V., Rocha, R., Sousa, M., Leite, J., Melo, F., Pimentel, J., Ventura, L., Vila Nova, C., Copaescu, C., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Domansky, N., Karachun, A., Moiseenko, A., Pelipas, Y., Petrov, A., Pravosudov, I., Aiupov, R., Akmalov, Y., Parfenov, A., Suleymanov, N., Tarasov, N., Jumabaev, H., Mamedli, Z., Rasulov, A., Aliev, I., Chernikovskiy, I., Kochnev, V., Komyak, K., Smirnov, A., Achkasov, S., Bolikhov, K., Shelygin, Y., Sushkov, O., Zapolskiy, A., Gvozdenovic, M., Jovanovic, D., Lausevic, Z., Cvetkovic, D., Maravic, M., Milovanovic, B., Stojakovic, N., Tripkovic, I., Mihajlovic, D., Nestorovic, M., Pecic, V., Petrovic, D., Stanojevic, G., Barisic, G., Dimitrijevic, I., Krivokapic, Z., Markovic, V., Popovic, M., Aleksic, A., Dabic, D., Kostic, I., Milojkovic, A., Perunicic, V., Lukic, D., Petrovic, T., Radovanovic, D., Radovanovic, Z., Cuk, V. 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D, Padwick, R, Torrance, A, Tsiamis, A, Dawson, P, Balfour, A, Brady, R, Mander, J, Paterson, H, Chandratreya, N, Chu, H, Cutting, J, Vernon, S, Wai Ho, C, Andreani, S, Patel, H, Warner, M, Yan Qi Tan, J, Iqbal, A, Khan, A, Perrin, K, Raza, A, Tan, S., and 2015 European Society of Coloproctology collaborating, Group
Subjects: creatinine blood level, adverse event, Disease, open surgery, surgery, 0302 clinical medicine, hospital readmission, postoperative complication, resection, Crohn's disease, Resection, Surgery, outcome, parenteral nutrition, postoperative complications, C reactive protein, adult, Gastroenterology, creatinine, Crohn disease, cohort analysis, female, priority journal, risk factor, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, abdominal abscess, anastomosis leakage, prospective study, medicine.medical_specialty, side to side anastomosis, surgical infection, reoperation, Anastomosis, Article, NO, 03 medical and health sciences, intestine resection, length of stay, male, medicine, intraoperative period, follow up, ileocecal resection, controlled study, human, Adverse effect, outcome assessment, preoperative period, ta3126, business.industry, Postoperative complication, Odds ratio, medicine.disease, surgical margin, major clinical study, Confidence interval, hemicolectomy, Parenteral nutrition, protein blood level, business, abscess drainage
Abstract: Aim: Patient- and disease-related factors, as well as operation technique, all have the potential to impact on postoperative outcome in Crohn's disease. The available evidence is based on small series and often displays conflicting results. The aim was to investigate the effect of preoperative and intra-operative risk factors on 30-day postoperative outcome in patients undergoing surgery for Crohn's disease. Method: This was an international prospective snapshot audit including consecutive patients undergoing right hemicolectomy or ileocaecal resection. The study analysed a subset of patients who underwent surgery for Crohn's disease. The primary outcome measure was the overall Clavien–Dindo postoperative complication rate. The key secondary outcomes were anastomotic leak, reoperation, surgical site infection and length of stay in hospital. Multivariable binary logistic regression analyses were used to produce odds ratios and 95% confidence intervals. Results: In all, 375 resections in 375 patients were included. The median age was 37 and 57.1% were women. In multivariate analyses, postoperative complications were associated with preoperative parenteral nutrition (OR 2.36, 95% CI 1.10–4.97), urgent/expedited surgical intervention (OR 2.00, 95% CI 1.13–3.55) and unplanned intra-operative adverse events (OR 2.30, 95% CI 1.20–4.45). The postoperative length of stay in hospital was prolonged in patients who received preoperative parenteral nutrition (OR 31, 95% CI 1.08–1.61) and those who had urgent/expedited operations (OR 1.21, 95% CI 1.07–1.37). Conclusion: Preoperative parenteral nutritional support, urgent/expedited operation and unplanned intra-operative adverse events were associated with unfavourable postoperative outcome. Enhanced preoperative optimization and improved planning of operation pathways and timings may improve outcomes for patients. Colorectal Disease © 2017 The Association of Coloproctology of Great Britain and Ireland
Published: 2018
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9. Relationship between method of anastomosis and anastomotic failure after right hemicolectomy and ileo-caecal resection : an international snapshot audit

Author: Pinkney, T., Battersby, N., Bhangu, A., Chaudhri, S., El-Hussuna, A., Frasson, M., Nepogodiev, D., Singh, B., Vennix, S., Zmora, O., Altomare, D., Bemelman, W., Christensen, P., D'Hoore, A., Laurberg, S., Morton, D., Rubbini, M., Vaizey, C., Magill, L., Perry, R., Sheward, N., Ives, N., Mehta, S., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Salomon, M., Makhmudov, A., Selnyahina, L., Varabei, A., Vizhynis, Y., Claeys, D., Defoort, B., Muysoms, F., Pletinckx, P., Vergucht, V., Debergh, I., Feryn, T., Reusens, H., Nachtergaele, M., Francart, D., Jehaes, C., Markiewicz, S., Monami, B., Weerts, J., Bouckaert, W., Houben, Bert, Knol, Joep, Sergeant, Gregory, Vangertruyden, G., Haeck, L., Lange, C., Sommeling, C., Vindevoghel, K., Castro, S., De Bruyn, H., Huyghe, M., De Wolf, E., Reynders, D., van Overstraeten, A. de Buck, Wolthuis, A., Delibegovic, S., Christiani, A., Marchiori, M., Jr., Rocha de Moraes, C., Tercioti, V., Jr., Arabadjieva, E., Bulanov, D., Dardanov, D., Stoyanov, V., Yonkov, A., Angelov, K., Maslyankov, S., Sokolov, M., Todorov, G., Toshev, S., Georgiev, Y., Karashmalakov, A., Zafirov, G., Wang, X., Condic, D., Kraljik, D., Mrkovic, H., Pavkovic, V., Raguz, K., Bencurik, V., Holaskova, E., Skrovina, M., Farkasova, M., Grolich, T., Kala, Z., Antos, F., Pruchova, V., Sotona, O., Chobola, M., Dusek, T., Ferko, A., Orhalmi, J., Hoch, J., Kocian, P., Martinek, L., Bernstein, I., Sunesen, K. Gotschalck, Leunbach, J., Thorlacius-Ussing, O., Oveson, A. Uth, Chirstensen, S. Dahl, Gamez, V., Oeting, M., Loeve, U. Schou, Ugianskis, A., Jessen, M., Krarup, P., Linde, K., Mirza, Q., Stovring, J. Overgaard, Erritzoe, L., Jakobsen, H. Loft, Lykke, J., Colov, E. Palmgren, Madsen, A. Husted, Friis, T. Linde, Funder, J. Amstrup, Dich, R., Kjaer, S., Rasmussen, S., Schlesinger, N., Kjaer, M. Dilling, Qvist, N., Khalid, A., Ali, G., Hadi, S., Walker, L. Rosell, Kivela, A., Lehtonen, T., Lepisto, A., Scheinin, T., Siironen, P., Kossi, J., Kuusanmaki, P., Tomminen, T., Turunen, A., Rautio, T., Vierimaa, M., Huhtinen, H., Karvonen, J., Lavonius, M., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Kepenekian, V., Passot, G., Maggiori, L., Manceau, G., Panis, Y., Gout, M., Rullier, E., van Geluwe, B., Chafai, N., Lefevre, J. 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Gonzalez, Hernandez, G., Perez Alvarez, A., Soto Sanchez, A., Cesar Becerra Garcia, F., Guillermo Alonso Roque, J., LÃ³pez RodrÃguez Arias, F., Del Valle Ruiz, S. R., De La Villa, G. SÃ¡nchez, Compaã±, A., GarcÃa MarÃn, A., Nofuentes, C., Orts MicÃ³, F., PÃ©rez Auladell, V., Carrasco, M., Duque Perez, C., GÃ¡lvez-Pastor, S., Navarro Garcia, I., Sanchez Perez, A., Enjuto, D., Manuel Bujalance, F., Marcelin, N., Pã©rez, M., Serrano GarcÃa, R., Cabrera, A., de la Portilla, F., Diaz-Pavon, J., Jimenez-Rodriguez, R., Vazquez-Monchul, J., Daza GonzÃ¡lez, J., GÃ³mez PÃ©rez, R., Rivera Castellano, J., de la Rua, J. RoldÃ¡n, Errasti Alustiza, J., Fernandez, L., Romeo Ramirez, J., Sardon Ramos, J., CermeÃ±o Toral, B., Alias, D., Garcia-Olmo, D., Guadalajara, H., Herreros, M., Pacheco, P., Lima, P., MartÃnez Alegre, J., Ortega, I., Picardo Nieto Antonio, A., Caro, A., Escuder, J., Feliu, F., Millan, M., Frangi Caregnato, A., Lozoya Trujillo, R., RodrÃguez Carrillo, R., Ruiz Carmona, M., Alonso, N., Ambrona Zafra, D., Amilka Ayala Candia, B. J., PineÃ±o Flores, C., Alcazar Montero, J., Angoso Clavijo, M., Garcia, J., Sanchez Tocino, J., GÃ³mez-Alcazar, C., Costa-Navarro, D., Ferri-Romero, J., Rey-Riveiro, M., Romero-SimÃ³, M., Arencibia, B., Esclapez, P., GarcÃa-Granero, E., Granero, P., Medina FernÃ¡ndez, F. J., Gallardo Herrera, A. B., Diaz LÃ³pez, C., Navarro Rodriguez, E., Torres Tordera, E., Arenal, J., Citores, M., Marcos, J., Sã¡nchez, J., Tinoco, C., Espin, E., Garcia Granero, A., Jimenez Gomez, L., Sanchez Garcia, J., Vallribera, F., Folkesson, J., Skã¶ldberg, F., Bergman, K., Borgstrã¶m, E., Frey, J., Silfverberg, A., Sã¶derholm, M., Nygren, J., Segelman, J., Gustafsson, D., Lagerqvist, A., Papp, A., Pelczar, M., Abraham-Nordling, M., Ahlberg, M., Sjovall, A., Tengstrom, J., Hagman, K., Chabok, A., Ezra, E., Nikberg, M., Smedh, K., Tiselius, C., Al-Naimi, N., Dao Duc, M., Meyer, J., Mormont, M., Ris, F., Prevost, G., Villiger, P., Hoffmann, H., Kettelhack, C., Kirchhoff, P., Oertli, D., Weixler, B., Aytac, B., Leventoglu, S., Mentes, B., Yuksel, O., Demirbas, S., Busra Ozkan, B., SelÃ§uk Ã–zbalci, G., Sungurtekin, U., Gã¼lcã¼, B., Ozturk, E., Yilmazlar, T., Challand, C., Fearnhead, N., Hubbard, R., Kumar, S., Arthur, J., Barben, C., Skaife, P., Slawik, S., Williams, M., Zammit, M., Barker, J., Sarantitis, I., Slawinski, C., Clifford, R., Eardley, N., Johnson, M., Mcfaul, C., Vimalachandran, D., Allan, S., Bell, A., Oates, E., Shanmugam, V., Brigic, A., Halls, M., Pucher, P., Stubbs, B., Agarwal, T., Chopada, A., Mallappa, S., Pathmarajah, M., Sugden, C., Brown, C., Macdonald, E., Mckay, A., Richards, J., Robertson, A., Kaushal, M., Patel, P., Tezas, S., Touqan, N., Ayaani, S., Marimuthu, K., Piramanayagam, B., Vourvachis, M., Iqbal, N., Korsgen, S., Seretis, C., Shariff, U., Arnold, S., Chan, H., Clark, E., Fernandes, R., Moran, B., Bajwa, A., Mcarthur, D., Cao, K., Cunha, P., Pardoe, H., Quddus, A., Theodoropoulou, K., Bolln, C., Denys, G., Gillespie, M., Manimaran, N., Reidy, J., Malik, A. I., Malik, A., Pitt, J., Aryal, K., El-Hadi, A., Lal, R., Pal, A., Velchuru, V., Oliveira Cunha, M., Thomas, M., Bains, S., Boyle, K., Miller, A., Norwood, M., Yeung, J., Goian, L., Gurjar, S., Saghir, W., Sengupta, N., Stewart-Parker, E., Bailey, S., Khalil, T., Lawes, D., Nikolaou, S., Omar, G., Church, R., Muthiah, B., Garrett, W., Marsh, P., Obeid, N., Chandler, S., Coyne, P., Evans, M., Hunt, L., Lim, J., Oliphant, Z., Papworth, E., Weaver, H., CuiÃ±as Leon, K., Williams, G., Hernon, J., Kapur, S., Moosvi, R., Shaikh, I., Swafe, L., Aslam, M., Evans, J., Ihedioha, U., Kang, P., Merchant, J., Hompes, R., Middleton, R., Broomfield, A., Crutten-Wood, D., Foster, J., Nash, G., Akhtar, M., Boshnaq, M., Eldesouky, S., Mangam, S., Rabie, M., Ahmed, J., Khan, J., Ming Goh, N., Shamali, A., Stefan, S., Thompson, C., Amin, A., Docherty, J., Lim, M., Walker, K., Watson, A., Hossack, M., Mackenzie, N., Paraoan, M., Alam, N., Daniels, I., Narang, S., Pathak, S., Smart, N., Al-Qaddo, A., Codd, R., Rutka, O., Bronder, C., Crighton, I., Davies, E., Raymond, T., Bookless, L., Griffiths, B., Plusa, S., Carlson, G., Harrison, R., Lees, N., Mason, C., Quayle, J., Branagan, G., Broadhurst, J., Chave, H., Sleight, S., Awad, F., Cruickshank, N., Joy, H., Boereboom, C., Daliya, P., Dhillon, A., Watson, N., Watson, R., Artioukh, D., Gokul, K., Javed, M., Kong, R., Sutton, J., Faiz, O., Jenkins, I., Leo, C. A., Samaranayake, S. F., Warusavitarne, J., Arya, S., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Duff, S., Fatayer, T., Mbuvi, J., Sharma, A., Cornish, J., Davies, L., Harries, R., Morris, C., Torkington, J., Knight, J., Lai, C., Shihab, O., Tzivanakis, A., Hussain, A., Luke, D., Padwick, R., Torrance, A., Tsiamis, A., Dawson, P., Balfour, A., Brady, R., Mander, J., Paterson, H., Chandratreya, N., Chu, H., Cutting, J., Vernon, S., Wai Ho, C., Andreani, S., Patel, H., Yan Qi Tan, J., Iqbal, A., Khan, A., Perrin, K., Raza, A., Tan, S., Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Surgery, Meyer, Jérémy, Al-Naimi, Noof, Mormont, Murielle, Ris, Frédéric, 2015 European Society of Coloproctology collaborating, Group, Rosati, R, Sileri, P, and Radiology and nuclear medicine
Subjects: medicine.medical_specialty, Leak, SURGERY, colorectal cancer, Audit, 030230 surgery, Anastomosis, Logistic regression, NO, Resection, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Primary outcome, All institutes and research themes of the Radboud University Medical Center, Anastomotic leak, colorectal cancer, Crohn's disease, epidemiology, international, Journal Article, Medicine, Anastomotic leak, LEAK, COMPLICATIONS, ddc:617, business.industry, MORTALITY, Gastroenterology, Crohns disease, anastomotic leak, crohn's disease, epidemiology, international, ta3121, 3. Good health, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Crohn's disease, DEFINITION, 030220 oncology & carcinogenesis, Mixed effects, RISK-FACTORS, business, Right hemicolectomy
Abstract: Aim The anastomosis technique used following right-sided colonic resection is widely variable and may affect patient outcome. This study aimed to assess the association between leak and anastomosis technique (stapled vs handsewn)., Method This was a prospective, multicentre, international audit including patients undergoing elective or emergency right hemicolectomy or ileo-caecal resection operations over a 2-month period in early 2015. The primary outcome measure was the presence of anastomotic leak within 30 days of surgery, determined using a prespecified definition. Mixed effects logistic regression models were used to assess the association between leak and anastomosis method, adjusting for patient, disease and operative cofactors, with centre included as a random-effect variable., Results This study included 3208 patients, of whom 78.4% (n = 2515) underwent surgery for malignancy and 11.7% (n = 375) underwent surgery for Crohn's disease. An anastomosis was performed in 94.8% (n = 3041) of patients, which was handsewn in 38.9% (n = 1183) and stapled in 61.1% (n = 1858). Patients undergoing hand-sewn anastomosis were more likely to be emergency admissions (20.5% handsewn vs 12.9% stapled) and to undergo open surgery (54.7% handsewn vs 36.6% stapled). The overall anastomotic leak rate was 8.1% (245/3041), which was similar following handsewn (7.4%) and stapled (8.5%) techniques (P = 0.3). After adjustment for cofactors, the odds of a leak were higher for stapled anastomosis (adjusted OR = 1.43; 95% CI: 1.04-1.95; P = 0.03)., Conclusion Despite being used in lower-risk patients, stapled anastomosis was associated with an increased anastomotic leak rate in this observational study. Further research is needed to define patient groups in whom a stapled anastomosis is safe.
Published: 2017
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10. The contribution of seismic noise and geological data to reconstruct the infilling architecture of the Norcia basin (Central Italy)

Author: Ruggieri, E., Di Giulio, G., Porreca, M., Ercoli, M., and Vassallo, M.
Published: 2018

11. Insights on the deep structure of the Norcia basin (Central Italy) by combination of geological data and seismic noise measurements

Author: Ercoli, M., Camilli, J., Di Giulio, G., Porreca, M., Vassallo, M., and Ruggieri, E.
Published: 2018

12. Role of exetended lymphadenectomy in gastric cancer surgery: A retrospective single centre experience

Author: Lomonaco, R., primary, De Luca, R., additional, Caliandro, C., additional, Ruggieri, E., additional, Nannavecchia, A., additional, Rucci, A., additional, Ammendola, M., additional, and Simone, M., additional
Published: 2018
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13. Study of the fragmentation of b quarks into B mesons at the Z peak

Author: Heister A, Schael S, Barate R, De Bonis I, Decamp D, Goy C, Lees JP, Merle E, Minard MN, Pietrzyk B, Bravo S, Casado MP, Chmeissani M, Crespo JM, Fernandez E, Fernandez Bosman M, Garrido L, Grauges E, Martinez M, Merino G, Miquel R, Mir LM, Pacheco A, Ruiz H, Colaleo A, Creanza D, de Palma M, Iaselli G, Maggi G, Maggi M, Nuzzo S, Ranieri A, Raso C, Ruggieri E, Selvaggi G, Silvestris L, Tempesta P, Tricomi A, Zito G, Huang X, Lin J, Ouyang Q, Wang T, Xie Y, Xu R, Xue S, Zhang J, Zhang L, Zhao W, Abbaneo D, Azzurri P, Boix G, Buchmuller O, Cattaneo M, Cerutti F, Clerbaux B, Dissertori G, Drevermann H, Forty RW, Frank M, Greening TC, Hansen JB, Harvey J, Janot P, Jost B, Kado M, Mato P, Moutoussi A, Ranjard F, Schlatter D, Schneider O, Spagnolo P, Tejessy W, Teubert F, Tournefier E, Ward J, Ajaltouni Z, Badaud F, Falvard A, Gay P, Henrard P, Jousset J, Michel B, Monteil S, Montret JC, Pallin D, Perret P, Podlyski F, Hansen PD, Hansen JR, Hansen PH, Nilsson BS, Waananen A, Kyriakis A, Markou C, Simopoulou E, Vayaki A, Zachariadou K, Blondel A, Bonneaud G, Brient JC, Rouge A, Rumpf M, Swynghedauw M, Verderi M, Videau H, Ciulli V, Focardi E, Parrini G, Antonelli A, Antonelli M, Bencivenni G, Bologna G, Bossi F, Campana P, Capon G, Chiarella V, Laurelli P, Mannocchi G, Murtas F, Murtas GP, Passalacqua L, Pepe Altarelli M, Halley AW, Lynch JG, Negus P, O'Shea V, Raine C, Thompson AS, Wasserbaech S, Cavanaugh R, Dhamotharan S, Geweniger C, Hanke P, Hansper G, Hepp V, Kluge EE, Putzer A, Sommer J, Tittel K, Werner S, Wunsch M, Beuselinck R, Binnie DM, Cameron W, Dornan PJ, Girone M, Marinelli N, Sedgbeer JK, Thompson JC, Ghete VM, Girtler P, Kneringer E, Kuhn D, Rudolph G, Bouhova Thacker E, Bowdery CK, Finch AJ, Foster F, Hughes G, Jones RWL, Pearson MR, Robertson NA, Giehl I, Jakobs K, Kleinknecht K, Quast G, Renk B, Rohne E, Sander HG, Wachsmuth H, Zeitnitz C, Bonissent A, Carr J, Coyle P, Leroy O, Payre P, Rousseau D, Talby M, Aleppo M, Ragusa F, David A, Dietl H, Ganis G, Huttmann K, Lutjens G, Mannert C, Manner W, Moser HG, Settles R, Stenzel H, Wiedenmann W, Wolf G, Boucrot J, Callot O, Davier M, Duflot L, Grivaz JF, Heusse P, Jacholkowska A, Lefrancois J, Veillet JJ, Videau I, Yuan C, Bagliesi G, Boccali T, Calderini G, Foa L, Giammanco A, Giassi A, Messineo A, Palla F, Sanguinetti G, Sciaba A, Sguazzoni G, Tenchini R, Venturi A, Verdini PG, Blair GA, Cowan G, Green MG, Medcalf T, Misiejuk A, Strong JA, Teixeira Dias P, von Wimmersperg Toeller JH, Clifft RW, Edgecock TR, Norton PR, Tomalin IR, Bloch Devaux B, Colas P, Emery S, Kozanecki W, Lancon E, Lemaire MC, Locci E, Perez P, Rander J, Renardy JF, Roussarie A, Schuller JP, Schwindling J, Trabelsi A, Vallage B, Konstantinidis N, Litke AM, Taylor G, Booth CN, Cartwright S, Combley F, Lehto M, Thompson LF, Affholderbach K, Bohrer A, Brandt S, Grupen C, Ngac A, Prange G, Sieler U, Giannini G, Rothberg J, Armstrong SR, Cranmer K, Elmer P, Ferguson DPS, Gao Y, Gonzalez S, Hayes OJ, Hu H, Jin S, Kile J, McNamara PA, Nielsen J, Orejudos W, Pan YB, Saadi Y, Scott IJ, Walsh J, Wu SL, Wu X, Zobernig G, RI ANTONELLI ANTONELLA/C 6238 2011 Jones Roger/H 5578 2011 Passalacqua Luca/F 5127 2011 Murtas Fabrizio/B 5729 2012 O'Shea Val/G 1279 2010, ROLANDI, LUIGI, LIGABUE, FRANCO, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), ALEPH, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Heister, A, Schael, S, Barate, R, De Bonis, I, Decamp, D, Goy, C, Lees, Jp, Merle, E, Minard, Mn, Pietrzyk, B, Bravo, S, Casado, Mp, Chmeissani, M, Crespo, Jm, Fernandez, E, Fernandez Bosman, M, Garrido, L, Grauges, E, Martinez, M, Merino, G, Miquel, R, Mir, Lm, Pacheco, A, Ruiz, H, Colaleo, A, Creanza, D, de Palma, M, Iaselli, G, Maggi, G, Maggi, M, Nuzzo, S, Ranieri, A, Raso, C, Ruggieri, E, Selvaggi, G, Silvestris, L, Tempesta, P, Tricomi, A, Zito, G, Huang, X, Lin, J, Ouyang, Q, Wang, T, Xie, Y, Xu, R, Xue, S, Zhang, J, Zhang, L, Zhao, W, Abbaneo, D, Azzurri, P, Boix, G, Buchmuller, O, Cattaneo, M, Cerutti, F, Clerbaux, B, Dissertori, G, Drevermann, H, Forty, Rw, Frank, M, Greening, Tc, Hansen, Jb, Harvey, J, Janot, P, Jost, B, Kado, M, Mato, P, Moutoussi, A, Ranjard, F, Rolandi, Luigi, Schlatter, D, Schneider, O, Spagnolo, P, Tejessy, W, Teubert, F, Tournefier, E, Ward, J, Ajaltouni, Z, Badaud, F, Falvard, A, Gay, P, Henrard, P, Jousset, J, Michel, B, Monteil, S, Montret, Jc, Pallin, D, Perret, P, Podlyski, F, Hansen, Pd, Hansen, Jr, Hansen, Ph, Nilsson, B, Waananen, A, Kyriakis, A, Markou, C, Simopoulou, E, Vayaki, A, Zachariadou, K, Blondel, A, Bonneaud, G, Brient, Jc, Rouge, A, Rumpf, M, Swynghedauw, M, Verderi, M, Videau, H, Ciulli, V, Focardi, E, Parrini, G, Antonelli, A, Antonelli, M, Bencivenni, G, Bologna, G, Bossi, F, Campana, P, Capon, G, Chiarella, V, Laurelli, P, Mannocchi, G, Murtas, F, Murtas, Gp, Passalacqua, L, Pepe Altarelli, M, Halley, Aw, Lynch, Jg, Negus, P, O'Shea, V, Raine, C, Thompson, A, Wasserbaech, S, Cavanaugh, R, Dhamotharan, S, Geweniger, C, Hanke, P, Hansper, G, Hepp, V, Kluge, Ee, Putzer, A, Sommer, J, Tittel, K, Werner, S, Wunsch, M, Beuselinck, R, Binnie, Dm, Cameron, W, Dornan, Pj, Girone, M, Marinelli, N, Sedgbeer, Jk, Thompson, Jc, Ghete, Vm, Girtler, P, Kneringer, E, Kuhn, D, Rudolph, G, Bouhova Thacker, E, Bowdery, Ck, Finch, Aj, Foster, F, Hughes, G, Jones, Rwl, Pearson, Mr, Robertson, Na, Giehl, I, Jakobs, K, Kleinknecht, K, Quast, G, Renk, B, Rohne, E, Sander, Hg, Wachsmuth, H, Zeitnitz, C, Bonissent, A, Carr, J, Coyle, P, Leroy, O, Payre, P, Rousseau, D, Talby, M, Aleppo, M, Ragusa, F, David, A, Dietl, H, Ganis, G, Huttmann, K, Lutjens, G, Mannert, C, Manner, W, Moser, Hg, Settles, R, Stenzel, H, Wiedenmann, W, Wolf, G, Boucrot, J, Callot, O, Davier, M, Duflot, L, Grivaz, Jf, Heusse, P, Jacholkowska, A, Lefrancois, J, Veillet, Jj, Videau, I, Yuan, C, Bagliesi, G, Boccali, T, Calderini, G, Foa, L, Giammanco, A, Giassi, A, Ligabue, Franco, Messineo, A, Palla, F, Sanguinetti, G, Sciaba, A, Sguazzoni, G, Tenchini, R, Venturi, A, Verdini, Pg, Blair, Ga, Cowan, G, Green, Mg, Medcalf, T, Misiejuk, A, Strong, Ja, Teixeira Dias, P, von Wimmersperg Toeller, Jh, Clifft, Rw, Edgecock, Tr, Norton, Pr, Tomalin, Ir, Bloch Devaux, B, Colas, P, Emery, S, Kozanecki, W, Lancon, E, Lemaire, Mc, Locci, E, Perez, P, Rander, J, Renardy, Jf, Roussarie, A, Schuller, Jp, Schwindling, J, Trabelsi, A, Vallage, B, Konstantinidis, N, Litke, Am, Taylor, G, Booth, Cn, Cartwright, S, Combley, F, Lehto, M, Thompson, Lf, Affholderbach, K, Bohrer, A, Brandt, S, Grupen, C, Ngac, A, Prange, G, Sieler, U, Giannini, G, Rothberg, J, Armstrong, Sr, Cranmer, K, Elmer, P, Ferguson, Dp, Gao, Y, Gonzalez, S, Hayes, Oj, Hu, H, Jin, S, Kile, J, Mcnamara, Pa, Nielsen, J, Orejudos, W, Pan, Yb, Saadi, Y, Scott, Ij, Walsh, J, Wu, Sl, Wu, X, Zobernig, G, and RI ANTONELLI ANTONELLA/C 6238 2011 Jones Roger/H 5578 2011 Passalacqua Luca/F 5127 2011 Murtas Fabrizio/B 5729 2012 O'Shea Val/G 1279, 2010
Subjects: Quark, Nuclear and High Energy Physics, Particle physics, Meson, Electron–positron annihilation, Nuclear Theory, Hadron, FOS: Physical sciences, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], B meson, Nuclear Experiment, 010306 general physics, ALEPH experiment, Physics, Missing energy, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Particle Physics - Experiment, Lepton
Abstract: The fragmentation of b quarks into B mesons is studied with four million hadronic Z decays collected by the ALEPH experiment during the years 1991-1995. A semi-exclusive reconstruction of B->l nu D(*) decays is performed, by combining lepton candidates with fully reconstructed D(*) mesons while the neutrino energy is estimated from the missing energy of the event. The mean value of xewd, the energy of the weakly-decaying B meson normalised to the beam energy, is found to be mxewd = 0.716 +- 0.006 (stat) +- 0.006 (syst) using a model-independent method; the corresponding value for the energy of the leading B meson is mxel = 0.736 +- 0.006 (stat) +- 0.006 (syst). The reconstructed spectra are compared with different fragmentation models., 21 pages, 5 figures
Published: 2001
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14. Image Gallery: A case of cutaneous giant angiosarcoma treated successfully with electrochemotherapy

Author: Guida, M., primary, Ruggieri, E., additional, Fucci, L., additional, Ressa, M., additional, D'Aluisio, L., additional, Fanelli, G., additional, and Strippoli, S., additional
Published: 2017
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15. Measurement of the upsilon(1S) production cross-section in pp collisions at root s=7 TeV in ATLAS ATLAS Collaboration

Author: Aad, G, Abbott, B, Abdallah, J, Abdelalim, A, Abdesselam, A, Abdinov, O, Abi, B, Abolins, M, Abramowicz, H, Abreu, H, Acerbi, E, Acharya, B, Adams, D, Addy, T, Adelman, J, Aderholz, M, Adomeit, S, Adragna, P, Adye, T, Aefsky, S, Aguilar Saavedra, J, Aharrouche, M, Ahlen, S, Ahles, F, Ahmad, A, Ahsan, M, Aielli, G, Akdogan, T, Akesson, T, Akimoto, G, Akimov, A, Akiyama, A, Alam, M, Albrand, S, Aleksa, M, Aleksandrov, I, Alessandria, F, Alexa, C, Alexander, G, Alexandre, G, Alexopoulos, T, Alhroob, M, Allev, M, Alimonti, G, Alison, J, Aliyevl, M, Allport, P, Allwood Spiers, S, Almond, J, Aloisio, A, Alon, R, Alonso, A, Alviggi, M, Amako, K, Amara, P, Amelung, C, Ammosov, V, Amorim, A, Amoros, G, Amram, N, Anastopoulos, C, Andari, N, Andeen, T, Anders, C, Anderson, K, Andreazza, A, Andrei, V, Andrieux, M, Anduaga, X, Angerami, A, Anghinolfi, F, Anjos, N, Annovi, A, Antonaki, A, Antonelli, M, Antonov, A, Antos, J, Anulli, F, Aoun, S, Bella, L, Apolle, R, Arabidze, G, Aracena, I, Arai, Y, Arce, A, Archambault, J, Arfaoui, S, Arguin, J, Arik, E, Arik, M, Armbruster, A, Arnaez, O, Arnault, C, Artamonov, A, Artoni, G, Arutinov, D, Asai, S, Asfandiyarov, R, Ask, S, Asman, B, Asquith, L, Assamagan, K, Astbury, A, Astvatsatourov, A, Atoian, G, Aubert, B, Auerbach, B, Auge, E, Augsten, K, Aurousseau, M, Austin, N, Avramidou, R, Axen, D, Ay, C, Azuelos, G, Azuma, Y, Baak, M, Baccaglioni, G, Bacci, C, Bach, A, Bachacou, H, Bachas, K, Bachy, G, Backes, M, Backhaus, M, Badescu, E, Bagnaia, P, Bahinipati, S, Bai, Y, Bailey, D, Bain, T, Baines, J, Baker, O, Baker, M, Baker, S, Pedrosa, F, Banas, E, Banerjee, P, Banerjee, S, Banfi, D, Bangert, A, Bansal, V, Bansi, H, Barak, L, Baranov, S, Barashkou, A, Galtieri, A, Barber, T, Barberio, E, Barberis, D, Barbero, M, Bardin, D, Barillari, T, Barisonzi, M, Barklow, T, Barlow, N, Barnett, B, Barnett, R, Baroncelli, A, Barone, G, Barr, A, Barreiro, F, da Costa, J, Barrillon, P, Bartoldus, R, Barton, A, Bartsch, D, Bartsch, V, Bates, R, Batkova, L, Batley, J, Battaglia, A, Battistin, M, Battistoni, G, Bauer, F, Bawa, H, Beare, B, Beau, T, Beauchemin, P, Beccherle, R, Bechtle, P, Beck, H, Beckingham, M, Becks, K, Beddall, A, Bedikian, S, Bednyakov, V, Bee, C, Begel, M, Harpaz, S, Behera, P, Beimforde, M, Belanger Champagne, C, Bell, P, Bell, W, Bella, G, Bellagamba, L, Bellina, F, Bellomo, M, Belloni, A, Beloborodova, O, Belotskiy, K, Beltramello, O, Ben Ami, S, Benary, O, Benchekroun, D, Benchouk, C, Bendel, M, Benedict, B, Benekos, N, Benhammou, Y, Benjamin, D, Benoit, M, Bensinger, J, Benslama, K, Bentvelsen, S, Berge, D, Kuutmann, E, Berger, N, Berghaus, F, Berglund, E, Beringer, J, Bernardet, K, Bernat, P, Bernhard, R, Bernius, C, Berry, T, Bertin, A, Bertinelli, F, Bertolucci, F, Besana, M, Besson, N, Bethke, S, Bhimji, W, Bianchi, R, Bianco, M, Biebel, O, Bieniek, S, Biesiada, J, Biglietti, M, Bilokon, H, Bindi, M, Binet, S, Bingul, A, Bini, C, Biscarat, C, Bitenc, U, Black, K, Blair, R, Blanchard, J, Blanchot, G, Blazek, T, Blocker, C, Blocki, J, Blondel, A, Blum, W, Blumenschein, U, Bobbink, G, Bobrovnikov, V, Bocchetta, S, Bocci, A, Boddy, C, Boehler, M, Boek, J, Boelaert, N, Boeser, S, Bogaerts, J, Bogdanchikov, A, Bogouch, A, Bohm, C, Boisvert, V, Bold, T, Boldea, V, Bolnet, N, Bona, M, Bondarenko, V, Boonekamp, M, Boorman, G, Booth, C, Bordoni, S, Borer, C, Borisov, A, Borissov, G, Borjanovic, I, Borroni, S, Bos, K, Boscherini, D, Bosman, M, Boterenbrood, H, Botterill, D, Bouchami, J, Boudreau, J, Bouhova Thacker, E, Boulahouache, C, Bourdarios, C, Bousson, N, Boveia, A, Boyd, J, Boyko, I, Bozhko, N, Bozovic Jelisavcic, I, Bracinik, J, Braem, A, Branchini, P, Brandenburg, G, Brandt, A, Brandt, G, Brandt, O, Bratzler, U, Brau, B, Brau, J, Braun, H, Brelier, B, Bremer, J, Brenner, R, Bressler, S, Breton, D, Britton, D, Brochu, F, Brock, I, Brock, R, Brodbeck, T, Brodet, E, Broggi, F, Bromberg, C, Brooijmans, G, Brooks, W, Brown, G, Brown, H, de Renstrom, P, Bruncko, D, Bruneliere, R, Brunet, S, Bruni, A, Bruni, G, Bruschi, M, Buanes, T, Bucci, F, Buchanan, J, Buchanan, N, Buchholz, P, Buckingham, R, Buckley, A, Buda, S, Budagov, I, Budick, B, Buescher, V, Bugge, L, Buira Clark, D, Bulekov, O, Bunse, M, Buran, T, Burckhart, H, Burdin, S, Burgess, T, Burke, S, Busato, E, Bussey, P, Buszello, C, Butin, F, Butler, B, Butler, J, Buttar, C, Butterworth, J, Buttinger, W, Byatt, T, Cabrera Urban, S, Caforio, D, Cakir, O, Calafiura, P, Calderini, G, Calfayan, R, Calkins, R, Caloba, L, Caloi, R, Calvet, D, Calvet, S, Toro, R, Camarri, P, Cambiaghi, M, Cameron, D, Campana, S, Campanelli, M, Canale, V, Canelli, F, Canepa, A, Cantero, J, Capasso, L, Garrido, M, Caprini, I, Caprini, M, Capriotti, D, Capua, M, Caputo, R, Caramarcu, C, Cardarelli, R, Carli, T, Carlino, G, Carminati, L, Caron, B, Caron, S, Montoya, G, Carter, A, Carter, J, Carvalho, J, Casadei, D, Casado, M, Cascella, M, Caso, C, Hernandez, A, Castaneda Miranda, E, Castillo Gimenez, V, Castro, N, Cataldi, G, Cataneo, F, Catinaccio, A, Catmore, J, Cattai, A, Cattani, G, Caughron, S, Cauzac, D, Cavalleri, P, Cavalli, D, Cavalli Sforza, M, Cavasinni, V, Ceradini, F, Cerqueira, A, Cerri, A, Cerrito, L, Cerutti, F, Cetin, S, Cevenini, F, Chafaq, A, Chakraborty, D, Chan, K, Chapleau, B, Chapman, J, Chareyre, E, Charlton, D, Chavda, V, Barajas, C, Cheatham, S, Chekanov, S, Chekulaev, S, Chelkov, G, Chelstowska, M, Chen, C, Chen, H, Chen, S, Chen, T, Chen, X, Cheng, S, Cheplakov, A, Chepurnov, V, Cherkaoui El Moursli, R, Chernyatin, V, Cheu, E, Cheung, S, Chevalier, L, Chiefari, G, Chikovani, L, Childers, J, Chilingarov, A, Chiodini, G, Chizhov, M, Choudalakis, G, Chouridou, S, Christidi, I, Christov, A, Chromek Burckhart, D, Chu, M, Chudoba, J, Ciapetti, G, Ciba, K, Ciftci, A, Ciftci, R, Cinca, D, Cindro, V, Ciobotaru, M, Ciocca, C, Ciocio, A, Cirilli, M, Ciubancan, M, Clark, A, Clark, P, Cleland, W, Clemens, J, Clement, B, Clement, C, Clifft, R, Coadou, Y, Cobaac, M, Coccaro, A, Cochran, J, Coe, P, Cogan, J, Coggeshal, J, Cogneras, E, Cojocaru, C, Colas, J, Colijn, A, Collard, C, Collins, N, Collins Tooth, C, Collot, J, Colon, G, Conde Muino, P, Coniavitis, E, Conidi, M, Consonni, M, Consorti, V, Constantinescu, S, Conta, C, Conventi, F, Cook, J, Cooke, M, Cooper, B, Cooper Sarkar, A, Cooper Smith, N, Copic, K, Cornelissen, T, Corradi, M, Corriveau, F, Cortes Gonzalez, A, Cortiana, G, Costa, G, Costa, M, Costanzo, D, Costin, T, Cote, D, Coura Torres, R, Courneyea, L, Cowan, G, Cowden, C, Cox, B, Cranmer, K, Crescioli, F, Cristinziani, M, Crosetti, G, Crupi, R, Crepe Renaudin, S, Cuciuc, C, Almenar, C, Donszelmann, T, Cuneo, S, Curatolo, M, Curtis, C, Cwetanski, P, Czirr, H, Czyczula, Z, D'Auria, S, D'Onofrio, M, D'Orazio, A, Da Silva, P, Da Via, C, Dabrowski, W, Dai, T, Dallapiccola, C, Dam, M, Dameri, M, Damiani, D, Danielsson, H, Dannheim, D, Dao, V, Darbo, G, Darlea, G, Daum, C, Dauvergne, J, Davey, W, Davidek, T, Davidson, N, Davidson, R, Davies, E, Davies, M, Davison, A, Davygora, Y, Dawe, E, Dawson, I, Dawson, J, Daya, R, De, K, de Asmundis, R, De Castro, S, Salgado, P, De Cecco, S, de Graat, J, De Groot, N, de Jong, P, De la Taille, C, De la Torre, H, De Lotto, B, De Mora, L, De Nooij, L, Branco, M, De Pedis, D, de Saintignon, R, De Salvo, A, De Sanctis, U, De Santo, A, De Regie, J, Dean, S, Dedovich, D, Degenhardt, J, Dehchar, M, Deile, M, Del Papa, C, Del Peso, J, Del Prete, T, Deliyergiyev, M, Dell'Acqua, A, Dell'Asta, L, Della Pietra, M, della Volpe, D, Delmastro, M, Delpierre, P, Delruelle, N, Delsart, P, Deluca, C, Demers, S, Demichev, M, Demirkoz, B, Deng, J, Denisov, S, Derendarz, D, Derkaoui, J, Derue, F, Dervan, R, Desch, K, Devetak, E, Deviveiros, P, Dewhurst, A, Dewilde, B, Dhaliwal, S, Dhullipudi, R, DI CIACCIO, A, Di Ciaccio, L, Di Girolamo, A, Di Girolamo, B, Di Luise, S, Di Mattia, A, Di Micco, B, Di Nardo, R, Di Simone, A, Di Sipio, R, Diaz, M, Diblen, F, Diehl, E, Dietrich, J, Dietzsch, T, Diglio, S, Yagci, K, Dingfelder, J, Dionisi, C, Dita, P, Dita, S, Dittus, F, Djama, F, Djobava, T, do Vale, M, Do Valle Wemans, A, Doan, T, Dobbs, M, Dobinson, R, Dobos, D, Dobson, E, Dobson, M, Dodd, J, Doglioni, C, Doherty, T, Doi, Y, Dolejsi, J, Dolenc, I, Dolezal, Z, Dolgoshein, B, Dohmae, T, Donadelli, M, Donega, M, Donini, J, Dopke, J, Doria, A, Dos Anjos, A, Dosil, M, Dotti, A, Dova, M, Dowell, J, Doxiadis, A, Doyle, A, Drasal, Z, Drees, J, Dressnandt, N, Drevermann, H, Driouichi, C, Dris, M, Dubbert, J, Dubbs, T, Dube, S, Duchovni, E, Duckeck, G, Dudarev, A, Dudziak, F, Duehrssen, M, Duerdoth, I, Duflot, L, Dufour, M, Dunford, M, Yildiz, H, Duxfield, R, Dwuznik, M, Dydak, F, Dzahini, D, Dueren, M, Ebenstein, W, Ebke, J, Eckert, S, Eckweiler, S, Edmonds, K, Edwards, C, Edwards, N, Ehrenfeld, W, Ehrich, T, Eifert, T, Eigen, G, Einsweiler, K, Eisenhandler, E, Ekelof, T, El Kacimi, M, Ellert, M, Elles, S, Ellinghaus, F, Ellis, K, Ellis, N, Elmsheuser, J, Elsing, M, Ely, R, Emeliyanov, D, Engelmann, R, Engl, A, Epp, B, Eppig, A, Erdmann, J, Ereditato, A, Eriksson, D, Ernst, J, Ernst, M, Ernwein, J, Errede, D, Errede, S, Ertel, E, Escalier, M, Escobar, C, Espinal Curull, X, Esposito, B, Etienne, F, Etienvre, A, Etzion, E, Evangelakou, D, Evans, H, Fabbri, L, Fabre, C, Fakhrutdinov, R, Falciano, S, Fang, Y, Fanti, M, Farbin, A, Farilla, A, Farley, J, Farooque, T, Farrington, S, Farthouat, P, Fassnacht, P, Fassouliotis, D, Fatholahzadeh, B, Favareto, A, Fayard, L, Fazio, S, Febbraro, R, Federic, R, Fedin, O, Fedorko, W, Fehling Kaschek, M, Feligioni, L, Fellmann, D, Felzmann, C, Feng, C, Feng, E, Fenyuk, A, Ferencei, J, Ferland, J, Fernando, W, Ferrag, S, Ferrando, J, Ferrara, V, Ferrari, A, Ferrari, P, Ferrari, R, Ferrer, A, Ferrer, M, Ferrere, D, Ferretti, C, Parodi, A, Fiascaris, M, Fiedler, F, Filipcic, A, Filippas, A, Filthaut, F, Fincke Keeler, M, Fiolhais, M, Fiorini, L, Firan, A, Fischer, G, Fischer, P, Fisher, M, Fisher, S, Flech, M, Fleck, I, Fleckner, J, Fleischmann, R, Fleischmann, S, Flick, T, Castillo, L, Flowerdew, M, Foehlisch, F, Fokitis, M, Martin, T, Forbush, D, Formica, A, Forti, A, Fortin, D, Foster, J, Fournier, D, Foussat, A, Fowler, A, Fowler, K, Fox, H, Francavilla, R, Franchino, S, Francis, D, Frank, T, Franklin, M, Franz, S, Fraternali, M, Fratina, S, French, S, Froesch, R, Froidevaux, D, Frost, J, Fukunaga, C, Torregrosa, E, Fuster, J, Gabaldon, C, Gabizon, O, Gadfort, T, Gadomski, S, Gagliardi, G, Gagnon, P, Galea, C, Gallas, E, Gallas, M, Gallo, V, Gallop, B, Gallus, P, Galyaev, E, Gan, K, Gao, Y, Gapienko, V, Gaponenko, A, Garberson, F, Garcia Sciveres, M, Garcia, C, Navarro, J, Gardner, R, Garelli, N, Garitaonandia, H, Garonne, V, Garvey, J, Gatti, C, Gaudio, G, Gaumer, O, Gaur, B, Gauthier, L, Gavrilenko, I, Gay, C, Gaycken, G, Gayde, J, Gazis, E, Ge, R, Gee, C, Geerts, D, Geich Gimbel, C, Gellerstedt, K, Gemme, C, Gemmell, A, Genest, M, Gentile, S, George, M, George, S, Gerlach, R, Gershon, A, Geweniger, C, Ghaziane, H, Ghez, P, Ghodbane, N, Giacobbe, B, Giagu, S, Giakoumopoulou, V, Giangiobbe, V, Gianotti, F, Gibbard, B, Gibson, A, Gibson, S, Gilbert, L, Gilchriese, M, Gilewsky, V, Gillberg, D, Gillman, A, Gingrich, D, Ginzburg, J, Giokaris, N, Giordano, R, Giorgi, F, Giovannini, P, Giraud, P, Giugni, D, Giunta, M, Giusti, R, Gjelsten, B, Gladilin, L, Glasman, C, Glatzer, J, Glazov, A, Glitza, K, Glonti, G, Godfrey, J, Godlewski, J, Goebel, M, Goepfert, T, Goeringer, C, Goessling, C, Goettfert, T, Goldfarb, S, Goldin, D, Golling, T, Golovnia, S, Gomes, A, Fajardo, L, Goncalo, R, Da Costa, J, Gonella, L, Gonidec, A, Gonzalez, S, Gonzalez de la Hoz, S, Gonzalez Silva, M, Gonzalez Sevilla, S, Goodson, J, Goossens, L, Gorbounov, P, Gordon, H, Gorelov, I, Gorfine, G, Gorini, B, Gorini, E, Gorisek, A, Gornicki, E, Gorokhov, S, Goryachev, V, Gosdzik, B, Gosselink, M, Gostkin, M, Gouanere, M, Eschrich, I, Gouighri, M, Goujdami, D, Goulette, M, Goussiou, A, Goy, C, Grabowska Bold, I, Grabski, V, Grafstroem, R, Grah, C, Grahn, K, Grancagnolo, F, Grancagnolo, S, Grassi, V, Gratchev, V, Grau, N, Gray, H, Gray, J, Graziani, E, Grebenyuk, O, Greenfield, D, Greenshaw, T, Greenwood, Z, Gregor, I, Grenier, P, Griffiths, J, Grigalashvili, N, Grillo, A, Grinstein, S, Grishkevich, Y, Grivaz, J, Grognuz, J, Groh, M, Gross, E, Grosse Knetter, J, Groth Jensen, J, Grybel, K, Guarino, V, Guest, D, Guicheney, C, Guida, A, Guillemin, T, Guindon, S, Guler, H, Gunther, J, Guo, B, Guo, J, Gupta, A, Gusakov, Y, Gushchin, V, Gutierrez, A, Gutierrez, R, Guttman, N, Gutzwiller, O, Guyot, C, Gwenlan, C, Gwilliam, C, Haas, A, Haas, S, Haber, C, Hackenburg, R, Hadavand, H, Hadley, D, Haefner, R, Hahn, F, Haider, S, Hajduk, Z, Hakobyan, H, Haller, J, Hamacher, K, Hamal, R, Hamilton, A, Hamilton, S, Han, H, Han, L, Hanagaki, K, Hance, M, Handel, C, Hanke, R, Hansen, J, Hansen, P, Hansson, P, Hara, K, Hare, G, Harenberg, T, Harkusha, S, Harper, D, Harrington, R, Harris, O, Harrison, K, Hartert, J, Hartjes, F, Haruyama, T, Harvey, A, Hasegawa, S, Hasegawa, Y, Hassani, S, Hatch, M, Hauff, D, Haug, S, Hauschild, M, Hauser, R, Havranek, M, Hawes, B, Hawkes, C, Hawkings, R, Hawkins, D, Hayakawa, T, Hayden, D, Hayward, H, Haywood, S, Hazen, E, He, M, Head, S, Hedberg, V, Heelan, L, Heim, S, Heinemann, B, Heisterkamp, S, Helary, L, Heller, M, Hellman, S, Helsens, C, Henderson, R, Henke, M, Henrichs, A, Correia, A, Henrot Versille, S, Henry Couannier, F, Hensel, C, Henss, T, Hernandez, C, Hernandez Jimenez, Y, Herrberg, R, Hershenhorn, A, Herten, G, Hertenberger, R, Hervas, L, Hessey, N, Hidvegia, A, Higon Rodriguez, E, Hill, D, Hill, J, Hill, N, Hiller, K, Hillert, S, Hillier, S, Hinchliffe, I, Hines, E, Hirose, M, Hirsch, F, Hirschbuehl, D, Hobbs, J, Hod, N, Hodgkinson, M, Hodgson, P, Hoecker, A, Hoeferkamp, M, Hoffman, J, Hoffmann, D, Hohlfeld, M, Holder, M, Holmes, A, Holmgren, S, Holy, T, Holzbauer, J, Homma, Y, Hong, T, van Huysduynen, L, Horazdovsky, T, Horn, C, Horner, S, Horton, K, Hostachy, J, Hou, S, Houlden, M, Hoummada, A, Howarth, J, Howell, D, Hristova, I, Hrivnac, J, Hruska, I, Hryn'Ova, T, Hsu, P, Hsu, S, Huang, G, Hubacek, Z, Hubaut, F, Huegging, F, Huffman, T, Hughes, E, Hughes, G, Hughes Jones, R, Huhtinen, M, Hurst, P, Hurwitz, M, Husemann, U, Huseynov, N, Huston, J, Huth, J, Iacobucci, G, Iakovidis, G, Ibbotson, M, Ibragimov, I, Ichimiya, R, Iconomidou Fayard, L, Idarraga, J, Idzik, M, Iengo, P, Igonkina, O, Ikegami, Y, Ikeno, M, Ilchenko, Y, Iliadis, D, Imbault, D, Imhaeuser, M, Imori, M, Ince, T, Inigo Golfin, J, Ioannou, P, Iodice, M, Ionescu, G, Irles Quiles, A, Ishii, K, Ishikawa, A, Ishino, M, Ishmukhametov, R, Issever, C, Istin, S, Itoh, Y, Ivashin, A, Iwanski, W, Iwasaki, H, Izen, J, Izzo, V, Jackson, B, Jackson, J, Jackson, P, Jaekel, M, Jain, V, Jakobs, K, Jakobsen, S, Jakubek, J, Jana, D, Jankowski, E, Jansen, E, Jantsch, A, Janus, M, Jarlskog, G, Jeanty, L, Jelen, K, Jen La Plante, I, Jenni, R, Jeremie, A, Jez, P, Jezequel, S, Jha, M, Ji, H, Ji, W, Jia, J, 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Zitoun, R, Zivkovic, L, Zmouchko, Vv, Zobernig, G, Zoccoli, A, Zolnierowski, Y, Zsenei, A, zur Nedden, M, Zutshi, V, and Zwalinski, L.
Subjects: Settore FIS/01 - Fisica Sperimentale, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract: ""A measurement of the cross-section for gamma(1S) -> mu(+)mu(-) production in proton-proton collisions at centre of mass energy of 7 TeV is presented. The cross-section is measured as a function of the gamma(1S) transverse momentum in two bins of rapidity, vertical bar y(gamma(1S))vertical bar < 1.2 and 1.2 < vertical bar y(gamma(1S))vertical bar < 2.4. The measurement requires that both muons have transverse momentum p(T)(mu) > 4 GeV and pseuclorapidity vertical bar eta(mu)vertical bar < 2.5 in order to reduce theoretical uncertainties on the acceptance, which depend on the poorly known polarisation. The results are based on an integrated luminosity of 1.13 pb(-1), collected with the ATLAS detector at the Large Hadron Collider. The cross-section measurement is compared to theoretical predictions: it agrees to within a factor of two with a prediction based on the NRQCD model including colour-singlet and colour-octet matrix elements as implemented in PYTHIA while it disagrees by up to a factor of ten with the next-to-leading order prediction based on the colour-singlet model. (C) 2011 CERN. Published by Elsevier B.V. All rights reserved.""
Published: 2011

16. Defunctioning stomas after low anterior resection for rectal cancer: Could we give up the habit? A ten-year “G. Paolo II” cancer research centre experience

Author: De Luca, R., primary, Ammendola, M., additional, Ruggieri, E., additional, Caliandro, C., additional, Rucci, A., additional, and Montemurro, S., additional
Published: 2016
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17. 361. Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastric cancer patients underwent to surgery

Author: Ammendola, M., primary, De Luca, R., additional, Squicciarino, A., additional, Vescio, G., additional, Ruggieri, E., additional, Caliandro, C., additional, Lomonaco, R., additional, Simone, M., additional, Sammarco, G., additional, Gadaleta, C.D., additional, Sacco, R., additional, and Girolamo, R., additional
Published: 2016
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18. Group cognitive behavioural therapy for outpatients with obsessive-compulsive disorder in a psychiatric service in Italy

Author: Pozza, A., primary, Domenichetti, S., additional, Tanini, A., additional, Ruggieri, E., additional, and Dèttore, D., additional
Published: 2016
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19. Vorläufige Ergebnisse der Pfortaderhochdruckbehandlung bei Lebercirrhose durch Unterbindung der Arteria hepatica

Author: Ruggieri, E.
Published: 1955
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20. Use of The Mini Nutritional Assessment to determine the Prevalence of Malnutrition And Cachexia In Patients Undergoing Surgery For Colorectal Carcinoma

Author: Daniele, A., primary, Divella, R., additional, De Luca, R., additional, Montemurro, S., additional, Ruggieri, E., additional, Caliandro, C., additional, Cilifrese, V., additional, Giotta, F., additional, Lioce, M., additional, Casadibari, M.T., additional, Mallamaci, R., additional, Casamassima, P., additional, Savino, E., additional, Atlante, A., additional, Cattedra, M., additional, and Abbate, I., additional
Published: 2015
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21. Obesity and colorectal cancer: adiponectin and tumor necrosis factor alfa a representative link between inflammation and cancer

Author: Divella, R., primary, Daniele, A., additional, De Luca, R., additional, Casamassima, P., additional, Savino, E., additional, Casamassima, A., additional, Micelli, G., additional, Carbonara, D., additional, Caliandro, C., additional, Ruggieri, E., additional, Montemurro, S., additional, Giotta, F., additional, Giuliani, F., additional, Sasanelli, C.S., additional, Cataldo, L., additional, and Abbate, I., additional
Published: 2015
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22. 291. Rectal cancer proctectomy without covering stoma. The “G. Paolo II” Cancer Research Centre experience

Author: De Luca, R., primary, Caliandro, C., additional, Ruggieri, E., additional, Rucci, A., additional, Graziano, G., additional, and Montemurro, S., additional
Published: 2014
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23. Avvelenamenti nel cane nella regione Abruzzo nel quadriennio 1997-2000

Author: Amorena, Michele, Calzetta, L., Ruggieri, E., Ricci, A., Cavaliere, M., and Crescenzo, G.
Published: 2001

24. Associazioni bentoniche da sedimenti di grotte carsiche in Sicilia

Author: DI GERONIMO, I, LA PERNA, R, Rosso, A, Sanfilippo, Rossana, and TADDEI RUGGIERI, E.
Published: 2000

25. Gli aborti virali del cavallo: indagine sulla prevalenza della rinopolmonite equina e dell'arterite virale equina in cavalli sportivi della provincia di Bologna

Author: Carluccio, Augusto, Marsilio, Fulvio, Tiscar, Pietro Giorgio, Ruggieri, E., and De Fanti, C.
Published: 1999

26. Serum tryptase and tissue c-kit expressing cells assessment in colo-rectal cancer patients: New predictive markers or molecular pharmacological targets?

Author: Ammendola, M., primary, Sacco, R., additional, Sammarco, G., additional, Ruggieri, E., additional, Montemurro, S., additional, Patruno, R., additional, Nardulli, P., additional, Zito, F.A., additional, De Sarro, G., additional, Gadaleta, C.D., additional, and Ranieri, G., additional
Published: 2013
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27. Heat Shock Proteins e la replicazione virale

Author: Marsilio, Fulvio, Tiscar, Pietro Giorgio, Ruggieri, E., and Gatti, A.
Published: 1997

28. Assessment of serum tryptase and c-Kit expressing cells from colorectal cancer patients who underwent radical surgery

Author: Ammendola, M., primary, Patruno, R., additional, Fortunato, A., additional, Rubini, R., additional, Capriuolo, G., additional, Ruggieri, E., additional, Sacco, R., additional, Montemurro, S., additional, Gadaleta, C.D., additional, and Ranieri, G., additional
Published: 2012
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29. 07 Serum tryptase as a new biomarker in colorectal cancer patients

Author: Ammendola, M., primary, Patruno, R., additional, Ruggieri, E., additional, Coviello, M., additional, Di Lecce, V., additional, Vacca, A., additional, Sacco, R., additional, Montemurro, S., additional, Gadaleta, C.D., additional, and Ranieri, G., additional
Published: 2012
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30. P.17.12 IS SERUM TRYPTASE LEVEL IN COLORECTAL CANCER PATIENTS A POSSIBLE NOVEL BIOMARKER OF DISEASE?

Author: De Ceglie, A., primary, Scotto, F., additional, Ruggieri, E., additional, Coviello, M., additional, Goffredo, V., additional, Patruno, R., additional, Montemurro, S., additional, Vacca, A., additional, Gadaleta, C.D., additional, and Ranieri, G., additional
Published: 2012
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31. Electrochemoterapy (ECT) for the treatment of superficial tumor localizations

Author: Guida, M., primary, Porcelli, G., additional, Ruggieri, E., additional, Zito, A., additional, Mattioli, V., additional, Montemurro, S., additional, and Colucci, G., additional
Published: 2009
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32. Electrochemotherapy (ECT) for the treatment of superficial tumour metastases

Author: Guida, M., primary, Porcelli, G., additional, Montemurro, S., additional, Ruggieri, E., additional, Mattioli, V., additional, Zito, A., additional, and Colucci, G., additional
Published: 2008
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33. Vorläufige Ergebnisse der Pfortaderhochdruckbehandlung bei Lebercirrhose durch Unterbindung der Arteria hepatica.

Author: Ruggieri, E.
Published: 1965
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34. Divergent Effects of Rapamycin on Mouse and Rat Cells Following Mitogenic Stimulation

Author: Olivera, D. L., Kaplan, J. M., Newman-Tarr, T., Ruggieri, E. V., and Badger, A. M.
Abstract: The immunosuppressive effects of cyclosporin A, FK506, and rapamycin were compared in mouse and rat systems of in vitro cellular stimulation. The inhibitory profile of rapamycin was distinctly different in the two species. In mouse systems, rapamycin caused a dose-dependent inhibition of both Ca²⁺-dependent (concanavalin A (Con A), phytohemagglutinin (PHA), and phorbol 12-myristate 13-acetate + ionomycin) and Ca²⁺-independent (lipopolysaccharide and PMA + interleukin-2) activation, whereas in the rat only Ca²⁺-independent responses were inhibited. Rapamycin's lack of activity in Ca²⁺-dependent responses in the rat does not appear to reside in a general insensitivity of this pathway to inhibition as cyclosporin A and FK506 demonstrated potent inhibitory activity. Additionally, rapamycin was able to block the inhibitory effect of FK506 on rat cells stimulated with the Ca²⁺-dependent stimulus, Con A. These results indicate a further dissociation in the biological activity of rapamycin compared to cyclosporin A and FK506 and may point to intriguing species differences in the immunosuppressive effects of these compounds in vitro. Copyright 1993, 1999 Academic Press
Published: 1993
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35. Screening policies, preventive measures and in-hospital infection of COVID-19 in global surgical practices

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A., Arcudi, C., Coco, C., Morales, C. M., Ali, M. Z., de Azevedo, C. T. M., Lozano, C. C., Sala, C., Leo, C. A., Scarpa, C. R., Ferro, C. V., Fernandez, C. M., Morales-Garcia, D., Nakano, D., Cristian, D., Hechtl, D., Canovas, D. T., Calabrese, D., Rega, D., Ferraro, D., Morezzi, D., Sommacale, D., Brogden, D., Miskovic, D., Merlini, D., Pertile, D., Coniglio, D., Zhu, D., Wu, D., Coletta, D., Rubio, D. R., Sasia, D., Fillipov, D., Russiello, D., Dardanov, D., Consten, E. C. J., Smolskas, E., Muttillo, E. M., Jones, E., Sunami, E., Etienne, E. -H., Chalkiadaki, E., Giacomelli, E., Karbovnichaya, E., Ruiz-Ucar, E., Guaitoli, E., Samadov, E., Jovine, E., Treppiedi, E., Vaterlini, E. M., Zambaiti, E., Moggia, E., Coetzee, E., Chisari, E., D'Errico, E., Ciofic, E., Pena, E., Kurt, E., Balik, E., Gunay, E., Sivrikoz, E., Andolfi, E., Araimo, E., Lucci, E., Opocher, E., Pinotti, E., Rubino, E., Reyhan, E., Mazzotta, E., Navarro, E. B., El-Helou, E., Licardie-Bolanos, E., Porto, E. I., Contreras, E., Boerma, E. -J., Cianchi, F., Marino, F., Uggeri, F., Han, F., Calculli, F., Falaschi, F., Ghignone, F., Perrone, F., Borghi, F., Garcia, F., Agresta, F., Cananzi, F. C. M., Mendoza-Moreno, F., Cengiz, F., Almeida, F. M., Baracchi, F., Carannante, F., la Torre, F., Fernandes, F., Friedmacher, F., Grama, F., Carissimi, F., Pecchini, F., Bianco, F., Colombo, F., Ferrara, F., Litta, F., Carrano, F. M., Martignoni, F., Tasselli, F. M., Milone, F., Pata, F., Sammartino, F., Zambianchi, F., Barragan, F., Herrero, F., Schlottmann, F., Den Boer, F. C., Pfeffer, F., Fujita, F., Navarra, G., Herrera-Almario, G., Pozzo, G., Capolupo, G. T., van Ramshorst, G. H., Liscia, G., Gallo, G., Asawa, G., Wang, G., Raiyani, G., Beets, G., Naval, G. S., Jin, G., Chang, G. J., Saakian, G., Kahane, G., Borroni, G., Lo Secco, G., Baiocchi, G. L., Baronio, G., Pagano, G., Pattacini, G. C., Lisi, G., Milito, G., Sinibaldi, G., Serrao, G., Bagaglini, G., Sarro, G., Brisinda, G., Candilio, G., Mangiameli, G., Giuliani, G., Martin-Martin, G. P., Bodzin, G., Leon, G., Mackay, G., Vasil, G., Palmisano, G., Giovanna, G. M., Fernandez, G. C., Steingel, G. B., Zhang, G., Choi, G. S., Chen, H., Hirose, H., Kayano, H., Ulgur, H. S., Impellizzeri, H., Ariola, H., Liu, H., Medina, H., Miyauchi, H., Takahashi, H., Hayashi, H., Ishikawa, H., Ishida, H., de Vries, H., Ulman, H., Kon, H., Ota, H., Akamatsu, H., Tamagawa, H., Shoji, H., Egi, H., Matsubara, H., Miki, H., Elfeki, H., Lin, H. -H., Giani, I., Caravaca-Garcia, I., Takemasa, I., Angriman, I., Negoi, I., Volkova, I., Russo, I., Kronberger, I. E., Shageev, I., Aydin, I., Mora-Guzman, I., Novak, I., Giuliano, I., Rachmuth, J., Ngu, J. C. -Y., Glasbey, J., Stoot, J., Zatecky, J., Melenhorst, J., van der Wal, J. B. C., Leijtens, J., Bogach, J., Elliott, J., de Wilt, J. H. W., Han, J., Cui, J., Liu, J., Khan, J., Wirawan, J. P., Zhang, J., Manyari, J. D. O., Doerner, J., Bock, J., Konsten, J., Castro, J. M., Grobas, J. P., Pinto, J. P., Juloski, J., Laina, J. L. B., Solorzano, J. J., Lopez, J. R. G., Li, J., Watanabe, J., Kwak, J. -M., Hasegawa, J., Hiro, J., Sergey, K., Zhang, K., Nagahori, K., Martinez, K., Tokuhara, K., Danno, K., Uehara, K., Yoshimatsu, K., Ehara, K., Ueda, K., Suda, K., Yamamoto, K., Ishimaru, K., Kimura, K., Hirata, K., Deen, K., Imaizumi, K., Yamada, J., Tanakura, K., Rida, K., Sugimoto, K., Kotaro, K., Shi, K., Okabayashi, K., Hida, K., Kataoka, K., Hongo, K., Xia, K., Tseng, L., Reime, L., Lorenzon, L., Ruano, L. M., Zhou, L., de Nes, L., Brandariz, L., Morini, L., Petagna, L., Ripamonti, L., Martinez, L. H., Pio, L., Sacco, L., Carvalho, L., Zorcolo, L., Perez-Sanchez, L. E., Esparza, L. H. R., Aguilar, L. T., Garner, M., Sugimoto, M., Nagashima, M., Shiozawa, M., Simone, M., Ferrer-Marquez, M., Carvalho, M., Alifano, M., Arganini, M., Calussi, M., Catarci, M., Allaix, M. E., Forlin, M., Milone, M., Paci, M., Fodor, M., Antipova, M., Martos, M. B., Giuffrida, M. C., Tabernilla, M. D., Quiros, M. J. A., Lemma, M., Correo, M. L. R. D., Malowiecka, M., Bellomo, M. P., Fernandez, M. R., Socias, M., Rizk, M., Aurora, M., Antolinez, M. A., Ninkovic, M., Giuffrida, M., Leeuwenburgh, M. M. N., de Roos, M. A. J., Lara, M. C., Agustin, M. C., Cuadrado, M., Pascual, M., Lemmerer, M., Carlos, R., Okamoto, M., Miyo, M., Inomata, M., Ikenaga, M., Tsujie, M., Yasuno, M., Kotake, M., Sato, M., Yasui, M., Lavazza, M., Rottoli, M., Zuin, M., Zuluaga, M., Cervellera, M., Cesari, M., Zizzo, M., Garino, M., Ghirardi, M., Montuori, M., Podda, M., Santarelli, M., Koc, M. A., Baini, M., de Cillia, M., de Rosa, M., Manigrasso, M., Zuolo, M., Cunha, M. F., Misca, M., Slavchev, M., Danilov, M., Shigaev, M., Martens, M., Kobayashi, M., Ren, M., Ishizuka, M., Hassan, M. M., Siblini, M., Sahloul, M., Keramati, M. R., Karunakaran, M., Markel, M., Majeed, M., Younis, M. U., Akin, M. I., Laraibe, M., Derebey, M., Kendirci, M., Fukunaga, M., Matsubara, N., Ordaz, N. E. C., Samalavicius, N. E., Keeratibharat, N., de Angelis, N., Gica, N., Mariani, N. M., Ramino, N., Falco, N., Smart, N., de Korte, N., Kok, N. F. M., Jamieson, N. B., Aberyasev, N., Bruklich, N., Ichikawa, N., Miyoshi, N., de Palma, N., Figueiredo, N., Torrecilla, N. O., Dybov, O. G., Yudin, O., Crepin, O., Gomez, O., Sert, O. Z., Lominchar, P. L., Menendez, P., de Nardi, P., Tejedor, P., Jordan, P., Tan, P., Marsanic, P., Natalya, P., Banos, P. P., Rebasa, P., Neary, P. M., Tanis, P., Giustacchini, P., Anoldo, P., Concejo, P., Cao, P., Chandrasinghe, P., Abeyratne, P., Wang, Q., Klicks, R. J., Mukai, R., Riquelme, R. F., de Luca, R., Galli, R., Gianesini, R., Moorjani, R. G., Deshpande, R. K., Gorter, R., Ledesma, R. L., Ruslan, R. -G., Chhabra, R., Talreja-Pelaez, R., Suzuki, R., Balestri, R., Rosati, R., Kiblawi, R., Martins, R., Angelico, R., Tutino, R., Persiani, R., Pollastri, R., Lopez, R. G., Perez, R. O., Hompes, R., Lukanin, R., Roser Termes, S. R., Brunaccino, R., Nakanishi, R., Stefan, S., Hernandez, S. P. S., Di Carlo, S., Ingallinella, S., Domoto, S., Ikeda, S., Mikalauskas, S., Kim, S. H., Mantova, S., Barbuta, S., Li, S., Yamaguchi, S., Yam-Agishi, S., Homma, S., Tsujinaka, S., Yoshioka, S., Mori, S., Tewari, S., Rayman, S., Horiuchi, S., Matoba, S., Morita, S., Yaman, S., Vigna, S., Testa, S., Ng, S., Deidda, S., Cicconi, S., Di Maria, S., Sibio, S., Ersoz, S., Pejkova, S., Altarifi, S., He, S., Malakorn, S., Meindert, S., Sumikawa, S., Parmar, S., Uranitsch, S., D'Ugo, S., Giuliani, S., Breukink, S., Lee, S. -H., Hata, T., Ishikawa, T., Akiyoshi, T., Azuma, T., Kobatake, T., Fukuzaki, T., Aiyama, T., Yamada, T., Garmanova, T., Gomez-Sanchez, T., Yamaguchi, T., de Jesus Flores, T., Usub, T., Tsuruma, T., Shimizu, T., Hristov, T. G., van Loon, T., Funakoshi, T., Manzia, T. M., Kiyomatsu, T., Katayama, T., Akagi, T., Mizushima, T., Kazuhito, U., Elmore, U., Grossi, U., Trucha, V. A., Rodriguez, V. S., Testa, V., Tonini, V., Celentano, V., Nekoval, V. M., Bettencourt, V., Mammadov, V., Leyva, V. A. G., Mariscal, V. G. O., Seid, V. E., Klemann, V., Turrado-Rodriguez, V., Papagni, V., Vento, V., Frering, V., Vigorita, V., Petrove, V. V., Lyadov, V., Fu, W., Mi, W., Jeong, W. K., Leclercq, W. K. G., de Sousa, X., Zhao, X., Li, X., Wang, X., Yang, X., Zhang, X., Zhen, Y., Dong, Y., Erushevich, Y., Takii, Y., Sumi, Y., Loli, Y. T., Yifat, Y. L., Shimada, Y., Nabeya, Y., Ide, Y., Wu, Y., Tsukada, Y., Miyamoto, Y., Toiyama, Y., Fujie, Y., Kaneko, Y., Mokutani, Y., Fujii, Y., Kanemitsu, Y., Medkova, Y., Chen, Y., Ruiz, Y. G., Kinugasa, Y., Sow, Z., Razzaq, Z., Wang, Z., Liu, Z., Han, Z., Tai, Z., Lai, Z., Ng, Z. Q., Dambrauskas, Z., Bellato, V, Konishi, T, Pellino, G, An, Y, Piciocchi, A, Sensi, B, Siragusa, L, Khanna, K, P, Bm, Franceschilli, M, Campanelli, M, Efetov, S, S Sica, G, Uggeri, F, Bellato V., Konishi T., Pellino G., An Y., Piciocchi A., Sensi B., Siragusa L., Khanna K., Pirozzi B.M., Franceschilli M., Rottoli M., Campanelli M., Efetov S., Sica G.S., on behalf of S-COVID Collaborative Group [ .., Tonini V., ], Bellato, Vittoria, Konishi, Tsuyoshi, Pellino, Gianluca, An, Yongbo, Piciocchi, Alfonso, Sensi, Bruno, Siragusa, Leandro, Khanna, Krishn, Pirozzi, Brunella Maria, Franceschilli, Marzia, Campanelli, Michela, Efetov, Sergey, Sica, Giuseppe S, Center of Experimental and Molecular Medicine, Graduate School, ACS - Pulmonary hypertension & thrombosis, AII - Infectious diseases, Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Surgery, Amsterdam Reproduction & Development (AR&D), and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
Subjects: Cross Infection/prevention & control, Cross-sectional study, Settore MED/18 - CHIRURGIA GENERALE, Coronavirus Infections/prevention & control, Practice Patterns, 0302 clinical medicine, Betacoronavirus, COVID-19, Coronavirus Infections, Cross Infection, Cross-Sectional Studies, Hospitals, Humans, Infection Control, Mass Screening, Pandemics, Pneumonia, Viral, Policy, Practice Patterns, Physicians, SARS-CoV-2, Surgical Procedures, Operative, Surveys and Questionnaires, Pandemic, Hospitals/standards, Infection control, 030212 general & internal medicine, Viral, Pandemics/prevention & control, Practice Patterns, Physicians', Research Theme 1: COVID-19 Pandemic, Pneumonia, Viral/prevention & control, Mass Screening/standards, Health Policy, Operative/adverse effects, Operative, screening policies, preventive measures, Human, Surgical Procedures, Operative/adverse effects, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), 030231 tropical medicine, MEDLINE, NO, Physicians'/standards, Hospital, 03 medical and health sciences, Physicians, medicine, Practice Patterns, Physicians'/standards, Mass screening, Cross-Sectional Studie, Physicians', Surgical Procedures, Betacoronaviru, Coronavirus Infection, business.industry, Preoperative screening, Public Health, Environmental and Occupational Health, Viral/prevention & control, Perioperative, Pneumonia, Settore MED/18, COVID-19, Coronavirus Infections, Cross Infection, Cross-Sectional Studies, Hospitals, Humans, Infection Control, Mass Screening, Pandemics, Pneumonia, Viral, Policy, Practice Patterns, Physicians', SARS-CoV-2, Surgical Procedures, Operative, Surveys and Questionnaires, coronavirus Infections, cross infection, cross-sectional studies, hospitals, humans, infection control, mass screening, pandemics, pneumonia, viral, policy, practice patterns, physicians', surgical procedures, operative, surveys and questionnaires, Family medicine, Infection Control/standards, business
Abstract: Background: In a surgical setting, COVID-19 patients may trigger in-hospital outbreaks and have worse postoperative outcomes. Despite these risks, there have been no consistent statements on surgical guidelines regarding the perioperative screening or management of COVID-19 patients, and we do not have objective global data that describe the current conditions surrounding this issue. This study aimed to clarify the current global surgical practice including COVID-19 screening, preventive measures and in-hospital infection under the COVID-19 pandemic, and to clarify the international gaps on infection control policies among countries worldwide.Methods: During April 2-8, 2020, a cross-sectional online survey on surgical practice was distributed to surgeons worldwide through international surgical societies, social media and personal contacts. Main outcome and measures included preventive measures and screening policies of COVID-19 in surgical practice and centers' experiences of in-hospital COVID-19 infection. Data were analyzed by country's cumulative deaths number by April 8, 2020 (high risk, >5000; intermediate risk, 100-5000; low risk, Results: A total of 936 centers in 71 countries responded to the survey (high risk, 330 centers; intermediate risk, 242 centers; low risk, 364 centers). In the majority (71.9%) of the centers, local guidelines recommended preoperative testing based on symptoms or suspicious radiologic findings. Universal testing for every surgical patient was recommended in only 18.4% of the centers. In-hospital COVID-19 infection was reported from 31.5% of the centers, with higher rates in higher risk countries (high risk, 53.6%; intermediate risk, 26.4%; low risk, 14.8%; P Conclusions: This large international survey captured the global surgical practice under the COVID-19 pandemic and highlighted the insufficient preoperative screening of COVID-19 in the current surgical practice. More intensive screening programs will be necessary particularly in severely affected countries/institutions.Study registration: Registered in ClinicalTrials.gov: NCT04344197.

36. An Intrapancreatic accessory spleen presenting as a neuroendocrine tumor

Author: Cartanese, C., Minardi, M., Crocco, A., Barile, G., RAFFAELE DE LUCA, Lomonaco, R., Rucci, A., Ruggieri, E., and Simone, M.

37. Pre-slaughtering stunning effects on small ruminants welfare: a review

Author: Trentini, R., Elisa Di Fede, Iannetti, L., Ruggieri, E., Di Nardo, A., and Villa, P. Dalla

38. Duplication cyst of the stomach with respiratory epithelium in adult: an uncommon finding. Report of case and review of literature

Author: Montemurro, S., Cartanese, C., RAFFAELE DE LUCA, Zito, F. A., Ranieri, G., and Ruggieri, E.

39. Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy

Author: Giorgia Careccia, Monica Canepari, Emilie Venereau, Anna Rubartelli, Deborah Recchia, Alessandro Preti, Marco Bianchi, Elena Ruggieri, Silvia Torchio, Claudio Bruno, Marielle Saclier, Michele Ferrara, Graziella Messina, Silvia Brunelli, Stefano C. Previtali, Elisa Principi, Andrea Gorzanelli, Maura Casalgrandi, Patrizia Castellani, Roberto Bottinelli, Isabella Lorenzetti, Lizzia Raffaghello, Patrizia Rovere-Querini, Mario Tirone, Careccia, G, Saclier, M, Tirone, M, Ruggieri, E, Principi, E, Raffaghello, L, Torchio, S, Recchia, D, Canepari, M, Gorzanelli, A, Ferrara, M, Castellani, P, Rubartelli, A, Rovere-Querini, P, Casalgrandi, M, Preti, A, Lorenzetti, I, Bruno, C, Bottinelli, R, Brunelli, S, Previtali, S, Bianchi, M, Messina, G, Vénéreau, E, Careccia, G., Saclier, M., Tirone, M., Ruggieri, E., Principi, E., Raffaghello, L., Torchio, S., Recchia, D., Canepari, M., Gorzanelli, A., Ferrara, M., Castellani, P., Rubartelli, A., Rovere-Querini, P., Casalgrandi, M., Preti, A., Lorenzetti, I., Bruno, C., Bottinelli, R., Brunelli, S., Previtali, S. C., Bianchi, M. E., Messina, G., and Venereau, E.
Subjects: Duchenne muscular dystrophy, chemical and pharmacologic phenomena, Inflammation, HMGB1, medicine.disease_cause, Mice, Fibrosis, Extracellular, medicine, Animals, Humans, Protein Isoforms, HMGB1 Protein, Muscular dystrophy, Muscle, Skeletal, biology, business.industry, BIO/13 - BIOLOGIA APPLICATA, Skeletal muscle, General Medicine, medicine.disease, Muscular Dystrophy, Duchenne, medicine.anatomical_structure, Mice, Inbred mdx, Cancer research, biology.protein, Muscular dystrophies, HMGB1, muscle, medicine.symptom, business, Oxidation-Reduction, Oxidative stress
Abstract: Muscular dystrophies (MDs) are a group of genetic diseases characterized by progressive muscle wasting associated to oxidative stress and persistent inflammation. It is essential to deepen our knowledge on the mechanism connecting these two processes because current treatments for MDs have limited efficacy and/or are associated with side effects. Here, we identified the alarmin high-mobility group box 1 (HMGB1) as a functional link between oxidative stress and inflammation in MDs. The oxidation of HMGB1 cysteines switches its extracellular activities from the orchestration of tissue regeneration to the exacerbation of inflammation. Extracellular HMGB1 is present at high amount and undergoes oxidation in patients with MDs and in mouse models of Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophy 3 (LGMDR3) compared to controls. Genetic ablation of HMGB1 in muscles of DMD mice leads to an amelioration of the dystrophic phenotype as evidenced by the reduced inflammation and muscle degeneration, indicating that HMGB1 oxidation is a detrimental process in MDs. Pharmacological treatment with an engineered nonoxidizable variant of HMGB1, called 3S, improves functional performance, muscle regeneration, and satellite cell engraftment in dystrophic mice while reducing inflammation and fibrosis. Overall, our data demonstrate that the balance between HMGB1 redox isoforms dictates whether skeletal muscle is in an inflamed or regenerating state, and that the nonoxidizable form of HMGB1 is a possible therapeutic approach to counteract the progression of the dystrophic phenotype. Rebalancing the HMGB1 redox isoforms may also be a therapeutic strategy for other disorders characterized by chronic oxidative stress and inflammation.
Published: 2021
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40. Effect of TNFa production inhibitors BRL 61063 and pentoxifylline on the response of rats to poly I:C

Author: Kaplan, J. M., Herzyk, D. J., Ruggieri, E. V., and Bartus, J. O'Leary
Published: 1995
Full Text: View/download PDF

41. Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions

Author: Michele Ferrara, Ginevra Chialli, Lorena Maria Ferreira, Elena Ruggieri, Giorgia Careccia, Alessandro Preti, Rosanna Piccirillo, Marco Emilio Bianchi, Giovanni Sitia, Emilie Venereau, Ferrara, M., Chialli, G., Ferreira, L. M., Ruggieri, E., Careccia, G., Preti, A., Piccirillo, R., Bianchi, M. E., Sitia, G., and Venereau, E.
Subjects: 0301 basic medicine, Male, Cachexia, muscle, cancer cachexia, inflammation, injury, leukocyte, liver, regeneration, tumor, Mice, 0302 clinical medicine, Fibrosis, Leukocytes, Tumor Microenvironment, Immunology and Allergy, HMGB1 Protein, Original Research, Mice, Knockout, Mice, Inbred BALB C, biology, Chemistry, Cell biology, medicine.anatomical_structure, medicine.symptom, Chemical and Drug Induced Liver Injury, Oxidation-Reduction, Settore BIO/17 - Istologia, lcsh:Immunologic diseases. Allergy, Immunology, Inflammation, chemical and pharmacologic phenomena, HMGB1, 03 medical and health sciences, Immune system, medicine, Animals, Muscle, Skeletal, Cell damage, Tumor microenvironment, Regeneration (biology), Skeletal muscle, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, biology.protein, lcsh:RC581-607, Spleen, 030215 immunology
Abstract: Acute inflammation is a complex biological response of tissues to harmful stimuli, such as pathogens or cell damage, and is essential for immune defense and proper healing. However, unresolved inflammation can lead to chronic disorders, including cancer and fibrosis. The High Mobility Group Box 1 (HMGB1) protein is a Damage-Associated Molecular Pattern (DAMP) molecule that orchestrates key events in inflammation by switching among mutually exclusive redox states. Fully reduced HMGB1 (frHMGB1) supports immune cell recruitment and tissue regeneration, while the isoform containing a disulphide bond (dsHMGB1) promotes secretion of inflammatory mediators by immune cells. Although it has been suggested that the tissue itself determines the redox state of the extracellular space and of released HMGB1, the dynamics of HMGB1 oxidation in health and disease are unknown. In the present work, we analyzed the expression of HMGB1 redox isoforms in different inflammatory conditions in skeletal muscle, from acute injury to muscle wasting, in tumor microenvironment, in spleen, and in liver after drug intoxication. Our results reveal that the redox modulation of HMGB1 is tissue-specific, with high expression of dsHMGB1 in normal spleen and liver and very low in muscle, where it appears after acute damage. Similarly, dsHMGB1 is highly expressed in the tumor microenvironment while it is absent in cachectic muscles from the same tumor-bearing mice. These findings emphasize the accurate and dynamic regulation of HMGB1 redox state, with the presence of dsHMGB1 tightly associated with leukocyte infiltration. Accordingly, we identified circulating, infiltrating, and resident leukocytes as reservoirs and transporters of dsHMGB1 in tissue and tumor microenvironment, demonstrating that the redox state of HMGB1 is controlled at both tissue and cell levels. Overall, our data point out that HMGB1 oxidation is a timely and spatially regulated process in physiological and pathological conditions. This precise modulation might play key roles to finetune inflammatory and regenerative processes.
Published: 2020

42. The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis

Author: Ugo Orfanelli, Floriana Cremasco, Chiara Fucci, Massimo Resnati, Francesca Paradiso, Tommaso Perini, Andrea Raimondi, Elena Ruggieri, Elena Riva, Elena Pasqualetto, Enrico Milan, Luca Rampoldi, Simone Cenci, Mario Nuvolone, Fucci, C, Resnati, M, Riva, E, Perini, T, Ruggieri, E, Orfanelli, U, Paradiso, F, Cremasco, F, Raimondi, A, Pasqualetto, E, Nuvolone, M, Rampoldi, L, Cenci, S, and Milan, E
Subjects: Male, 0301 basic medicine, plasma cell, Endoplasmic Reticulum, Nucleotidyltransferase, 0302 clinical medicine, antibody, Sequestosome-1 Protein, Homeostasis, lcsh:QH301-705.5, education.field_of_study, Chemistry, bortezomib, Nucleotidyltransferases, Proteasome Inhibitor, Cell biology, secretion, Female, Multiple Myeloma, Proteasome Inhibitors, Human, Protein Binding, Intracellular Membrane, Protein Domain, p62/SQSTM1, Plasma Cells, Immunoglobulins, FNDC3B, Protein degradation, General Biochemistry, Genetics and Molecular Biology, Protein Aggregates, 03 medical and health sciences, Sequestosome 1, Protein Domains, Cell Line, Tumor, Homeostasi, Immunoglobulin, Autophagy, Animals, Humans, Secretion, FAM46C, Gene Silencing, education, Fibronectin, Tumor Suppressor Protein, Endoplasmic reticulum membrane, Animal, Tumor Suppressor Proteins, Endoplasmic reticulum, Intracellular Membranes, Fibronectins, Mice, Inbred C57BL, 030104 developmental biology, Proteostasis, Secretory protein, lcsh:Biology (General), Membrane protein, Protein Aggregate, Positive Regulatory Domain I-Binding Factor 1, 030217 neurology & neurosurgery
Abstract: FAM46C is a non-canonical poly(A) polymerase uniquely mutated in up to 20% of multiple myeloma (MM) patients, implying a tissue-specific tumor suppressor function. Here, we report that FAM46C selectively stabilizes mRNAs encoding endoplasmic reticulum (ER)-targeted proteins, thereby concertedly enhancing the expression of proteins that control ER protein import, folding, N-glycosylation, and trafficking and boosting protein secretion. This role requires the interaction with the ER membrane resident proteins FNDC3A and FNDC3B. In MM cells, FAM46C expression raises secretory capacity beyond sustainability, inducing ROS accumulation, ATP shortage, and cell death. FAM46C activity is regulated through rapid proteasomal degradation or the inhibitory interaction with the ZZ domain of the autophagic receptor p62 that hinders its association with FNDC3 proteins via sequestration in p62+ aggregates. Altogether, our data disclose a p62/FAM46C/FNDC3 circuit coordinating sustainable secretory activity and survival, providing an explanation for the MM-specific oncosuppressive role of FAM46C and uncovering potential therapeutic opportunities against cancer. Fucci et al. show that the poly(A) polymerase FAM46C acts as a multiple myeloma-specific tumor suppressor, increasing secretory capacity and antibody production beyond sustainability via its interaction with endoplasmic reticulum transmembrane FNDC3 proteins. Moreover, its activity is restricted through proteasomal degradation or p62-dependent aggregation and sequestration from FNDC3 proteins.
Published: 2020

43. Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation

Author: R Alessia Battista, Leone Giordano, Mario Bussi, Francesca Paradiso, Enrico Milan, Elena Ruggieri, Floriana Cremasco, Massimo Resnati, Simone Cenci, Cecilia Facchi, Ugo Orfanelli, Alessia Battista, R., Resnati, M., Facchi, C., Ruggieri, E., Cremasco, F., Paradiso, F., Orfanelli, U., Giordano, L., Bussi, M., Cenci, S., and Milan, E.
Subjects: 0301 basic medicine, lcsh:Medicine, Gene Expression, Docetaxel, medicine.disease_cause, Biochemistry, Antioxidants, Ubiquitin, Sequestosome-1 Protein, Medicine and Health Sciences, Enzyme assays, Neoplasms, Glandular and Epithelial, Colorimetric assays, lcsh:Science, Bioassays and physiological analysis, Chemotherapeutic Agents, Cellular Stress Responses, chemistry.chemical_classification, Multidisciplinary, MTT assay, Cell Death, Pharmaceutics, Drugs, Gene Expression Regulation, Neoplastic, Oncology, Cell Processes, Oncology Agents, Fluorouracil, medicine.drug, Research Article, Autophagic Cell Death, Down-Regulation, Antineoplastic Agents, Biology, 03 medical and health sciences, Downregulation and upregulation, Protein Domains, Drug Therapy, Cell Line, Tumor, medicine, Autophagy, Genetics, Humans, Cisplatin, Pharmacology, Reactive oxygen species, lcsh:R, Biology and Life Sciences, Cell Biology, Research and analysis methods, Oxidative Stress, 030104 developmental biology, chemistry, Cell culture, Drug Resistance, Neoplasm, Cancer cell, Mutation, Biochemical analysis, biology.protein, Cancer research, lcsh:Q, Oxidative stress
Abstract: To cope with intrinsic and environmental stress, cancer cells rely on adaptive pathways more than non-transformed counterparts. Such non-oncogene addiction offers new therapeutic targets and strategies to overcome chemoresistance. In an attempt to study the role of adaptive pathways in acquired drug resistance in carcinoma cells, we devised a model of in vitro conditioning to three standard chemotherapeutic agents, cisplatin, 5-fluorouracil, and docetaxel, from the epithelial cancer cell line, HEp-2, and investigated the mechanisms underlying reduced drug sensitivity. We found that triple-resistant cells suffered from higher levels of oxidative stress, and showed heightened anti-stress responses, including the antioxidant Nrf2 pathway and autophagy, a conserved pleiotropic homeostatic strategy, mediating the clearance of aggregates marked by the adapter p62/SQSTM1. As a result, re-administration of chemotherapeutic agents failed to induce further accumulation of reactive oxygen species and p62. Moreover, autophagy proved responsible for chemoresistance through the avoidance of p62 accumulation into toxic protein aggregates. Indeed, p62 ablation was sufficient to confer resistance in parental cells, and genetic and pharmacological autophagic inhibition restored drug sensitivity in resistant cells in a p62-dependent manner. Finally, exogenous expression of mutant p62 lacking the ubiquitin- and LC3-binding domains, required for autophagic engulfment, increased chemosensitivity in TDR HEp-2 cells. Altogether, these findings offer a cellular system to investigate the bases of acquired chemoresistance of epithelial cancers and encourage challenging the prognostic and anti-neoplastic therapeutic potential of p62 toxicity.
Published: 2018

44. James Joyce and Socialist Realism: from Censorship to Rehabilitation

Author: Ilaria Aletto, F. Ruggieri, E. Terrinoni, and Aletto, Ilaria
Published: 2014

45. After Ellmann, the current state of Joyce biography

Author: Mccourt, JOHN FRANCIS, Franca Ruggieri e Anne Fogarty, and MC COURT, JOHN FRANCIS
Subjects: James Joyce, RIchard Ellmann, biography, biography, James Joyce, RIchard Ellmann
Abstract: A study of the problematics of Joyce biography in the post-Ellmann era.
Published: 2012

46. Observation of an excess in the search for the Standard Model Higgs boson at ALEPH

Author: M. Pepe-Altarelli, P. Girtler, H. Przysiezniak, G. Giannini, M. C. Lemaire, C. Markou, J. C. Brient, V. Ciulli, S. Werner, P. A. McNamara, H. Drevermann, F. Ruggieri, E. Rohne, G. Prange, V. Hepp, G. Merino, Ph Heusse, M. Aleppo, W. Zhao, Mario Antonelli, S. Xue, D. Fouchez, L.T. Jones, F. Ranjard, Donato Creanza, A. S. Thompson, E. Merle, D.P.S. Ferguson, A. Pacheco, Fabio Cerutti, M. I. Martínez, G. Ellis, B. Bloch-Devaux, Lei Zhang, M-N Minard, Piero Giorgio Verdini, B. Michel, S. Dhamotharan, B. Pietrzyk, Lucia Silvestris, A. W. Halley, A. Moutoussi, Alessandro Giassi, J. J. Veillet, Ting-Chi Wang, Roberto Tenchini, Val O'Shea, Giuseppe Raso, D.P. Clarke, Jean-Claude Montret, Timothy Barklow, P. Henrard, B. Vallage, A. Ealet, Eric Lancon, F. Foster, Evelina Vassileva Bouhova-Thacker, G. Ganis, P. R. Norton, P. Coyle, N. A. Robertson, A. J. Finch, Lorenzo Foà, Salvatore Nuzzo, L. F. Thompson, C. Borean, E. Grauges, S. Brandt, C. Curtil, Alan Litke, G. Rizzo, Alessia Tricomi, Ll. M. Mir, N. De Filippis, M.R. Pearson, Christian Zeitnitz, Gy. Wolf, B. Jost, M H. Lehto, G. P. Murtas, Werner Wiedenmann, A. Vayaki, Pablo Rodriguez Perez, R. Beuselinck, A. Bonissent, Emmerich Kneringer, F. Machefert, J. J. Walsh, Nancy Marinelli, R. W. Clifft, K. Hüttmann, G. A. Cowan, Franco Ligabue, P. Ghez, Maria Girone, J. Lopez, A.E. Wright, E. E. Kluge, J. Boucrot, Maria Pilar Casado, B. S. Nilsson, Giacomo Sguazzoni, Andrea Valassi, L. Passalacqua, Dominique Pallin, F. Hölldorfer, J. B. De Vivie De Regie, T.C. Greening, X. Huang, G. Sanguinetti, S. Bravo, T. Medcalf, K. Affholderbach, Claus Grupen, A. Misiejuk, Patrick Janot, Paolo Laurelli, F. Teubert, Chang-Zheng Yuan, A. Jacholkowska, Gavin Davies, M. Chmeissani, Richard Cavanaugh, G. Hughes, B. Gobbo, J. Putz, Djamel Eddine Boumediene, A. Putzer, Y. Saadi, F. Murtas, Marco Cattaneo, D. Decamp, J. Carr, A. Tilquin, H. G. Moser, Giuseppe Iaselli, Alberto Messineo, P. Colas, J. P. Lees, John H. L. Hansen, B. Renk, Karl Jakobs, D. M. Binnie, Ettore Focardi, Boris Tuchming, Ramon Miquel, F. Bossi, M. Swynghedauw, N. Konstantinidis, R. White, Evelyn Thomson, R. Xu, John Rander, Duccio Abbaneo, J. F. Renardy, Elizabeth Locci, Aristotelis Kyriakis, J. Nowell, M. Wunsch, J. H. von Wimmersperg-Toeller, P. Teixeira-Dias, P. Perret, I. Giehl, T. Ziegler, B. Fabbro, F. Podlyski, A. Heister, M. Davier, J. Hess, P. Campana, Roger Jones, J.M. Pascolo, Georgios Daskalakis, Laurent Serin, Sau Lan Wu, Laurent Duflot, P. Payre, J.D. Hansen, Oliver Buchmuller, S. Wasserbaech, Paolo Spagnolo, A. Wäänänen, J. Kennedy, H. Dietl, D. Schlatter, Marumi Kado, M. G. Green, A. Trabelsi, M. Kröcker, H.-A. Nürnberger, G.A. Blair, A. Ranieri, Jie Zhang, C. Goy, L. Rolandi, A. Rougé, Q. Ouyang, I. Videau, J.J. Ward, Y. B. Pan, T. R. Edgecock, J. Kile, S. Monteil, A. Böhrer, E. Fernandez, S. Schmeling, Giorgio Maggi, H. Ruiz, C. N. Booth, E. Simopoulou, H. G. Sander, V. M. Ghete, Paul Hodgson, K. Zachariadou, F. Badaud, S. L. Cartwright, Dirk Zerwas, F. Martin, J. Jousset, Michael Schmitt, J. A. Strong, G. Calderini, Gunter Quast, Kyle Cranmer, A. Antonelli, C. Loomis, K. Tittel, J.C. Thompson, V. Lemaitre, Y. S. Gao, S. Dessagne, O.J. Hayes, F. Ragusa, J. Rothberg, Xin Wu, R. Settles, M. Maggi, F. Combley, G. Bologna, M. Chalmers, P. Mato, U. Sieler, Simone Gilardoni, A. Sciabà, W. Cameron, G. Capon, J. M. Crespo, H. Videau, G. Lütjens, David J. Smith, G. Mannocchi, Maria Smizanska, André Rosowsky, G. Zobernig, S. Gonzalez, Alain Falvard, Konrad Kleinknecht, G. B. Taylor, J. Steinberger, D. Fayolle, O. Schneider, A. Minten, M. De Palma, G. Zito, W. Tejessy, W. Orejudos, David Hutchcroft, David Rousseau, B. Raeven, Ian R Tomalin, P. Hanke, P. H. Hansen, John-Bjarne Hansen, Andrea Giammanco, I.J. Scott, Peter Elmer, J. Nielsen, Fabrizio Palla, C. Mannert, C. Geweniger, Hasko Stenzel, W. Männer, Anna Colaleo, S.R. Armstrong, Yuehong Xie, T. Kachelhoffer, Giuseppe Bagliesi, Stephane Jezequel, A.-S. Müller, J. K. Sedgbeer, O. Callot, David Paneque, H. Hu, P. Maley, S. Jin, Olivier Leroy, S. Schael, G. Parrini, Tommaso Boccali, Paolo Azzurri, Günther Dissertori, Andrea Venturi, M. Fernandez-Bosman, V. Chiarella, F. Gianotti, J. Harvey, G. Bencivenni, Barbara Clerbaux, Reisaburo Tanaka, P. Seager, G. Rudolph, Markus Frank, E. Tournefier, C. K. Bowdery, A. Blondel, J. G. Lynch, H. He, R. Barate, I. De Bonis, Ll. Garrido, J. Lin, N. Shao, H. Wachsmuth, Giovanna Selvaggi, J. Coles, P. Tempesta, G. Leibenguth, G. Boix, Ziad Ajaltouni, Jean-Francois Grivaz, P. Negus, JunJie Wu, P. J. Dornan, A. David, R. W. Forty, D. Kuhn, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), ALEPH, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Barate, R, De Bonis, I, Decamp, D, Ghez, P, Goy, C, Jezequel, S, Lees, Jp, Martin, F, Merle, E, Minard, Mn, Pietrzyk, B, Bravo, S, Casado, Mp, Chmeissani, M, Crespo, Jm, Fernandez, E, Fernandez-Bosman, M, Garrido, L, Grauges, E, Lopez, J, Martinez, M, Merino, G, Miquel, R, Mir, Lm, Pacheco, A, Paneque, D, Ruiz, H, Colaleo, A, Creanza, D, De Filippis, N, de Palma, M, Iaselli, G, Maggi, G, Maggi, M, Nuzzo, S, Ranieri, A, Raso, G, Ruggieri, E, Selvaggi, G, Silvestris, L, Tempesta, P, Tricomi, A, Zito, G, Huang, X, Lin, J, Ouyang, Q, Wang, T, Xie, Y, Xu, R, Xue, S, Zhang, J, Zhang, L, Zhao, W, Abbaneo, D, Azzurri, P, Barklow, T, Boix, G, Buchmuller, O, Cattaneo, M, Cerutti, F, Clerbaux, B, Dissertori, G, Drevermann, H, Forty, Rw, Frank, M, Gianotti, F, Greening, Tc, Hansen, Jb, Harvey, J, Hutchcroft, De, Janot, P, Jost, B, Kado, M, Lemaitre, V, Maley, P, Mato, P, Minten, A, Moutoussi, A, Ranjard, F, Rolandi, L, Schlatter, D, Schmitt, M, Schneider, O, Spagnolo, P, Tejessy, W, Teubert, F, Tournefier, E, Valassi, A, Ward, Jj, Wright, Ae, Ajaltouni, Z, Badaud, F, Dessagne, S, Falvard, A, Fayolle, D, Gay, P, Henrard, P, Jousset, J, Michel, B, Monteil, S, Montret, Jc, Pallin, D, Pascolo, Jm, Perret, P, Podlyski, F, Hansen, Jd, Hansen, Jr, Hansen, Ph, Nilsson, B, Waananen, A, Daskalakis, G, Kyriakis, A, Markou, C, Simopoulou, E, Vayaki, A, Blondel, A, Brient, Jc, Machefert, F, Rouge, A, Swynghedauw, M, Tanaka, R, Videau, H, Focardi, E, Parrini, G, Zachariadou, K, Antonelli, A, Antonelli, M, Bencivenni, G, Bologna, G, Bossi, F, Campana, P, Capon, G, Chiarella, V, Laurelli, P, Mannocchi, G, Murtas, F, Murtas, Gp, Passalacqua, L, Pepe-Altarelli, M, Chalmers, M, Halley, Aw, Kennedy, J, Lynch, Jg, Negus, P, O'Shea, V, Raeven, B, Smith, D, Teixeira-Dias, P, Thompson, A, Cavanaugh, R, Dhamotharan, S, Geweniger, C, Hanke, P, Hepp, V, Kluge, Ee, Leibenguth, G, Putzer, A, Tittel, K, Werner, S, Wunsch, M, Beuselinck, R, Binnie, Dm, Cameron, W, Davies, G, Dornan, Pj, Girone, M, Marinelli, N, Nowell, J, Przysiezniak, H, Sedgbeer, Jk, Thompson, Jc, Thomson, E, White, R, Ghete, Vm, Girtler, P, Kneringer, E, Kuhn, D, Rudolph, G, Bouhova-Thacker, E, Bowdery, Ck, Clarke, Dp, Ellis, G, Finch, Aj, Foster, F, Hughes, G, Jones, Rwl, Pearson, Mr, Robertson, Na, Smizanska, M, Giehl, I, Holldorfer, F, Jakobs, K, Kleinknecht, K, Krocker, M, Muller, A, Nurnberger, Ha, Quast, G, Renk, B, Rohne, E, Sander, Hg, Schmeling, S, Wachsmuth, H, Zeitnitz, C, Ziegler, T, Bonissent, A, Carr, J, Coyle, P, Curtil, C, Ealet, A, Fouchez, D, Leroy, O, Kachelhoffer, T, Payre, P, Rousseau, D, Tilquin, A, Aleppo, M, Gilardoni, S, Ragusa, F, David, A, Dietl, H, Ganis, G, Heister, A, Huttmann, K, Lutjens, G, Mannert, C, Manner, W, Moser, Hg, Schael, S, Settles, R, Stenzel, H, Wolf, G, Boucrot, J, Callot, O, Davier, M, Duflot, L, Grivaz, Jf, Heusse, P, Jacholkowska, A, Serin, L, Veillet, Jj, Videau, I, de Regie, Jbd, Yuan, C, Zerwas, D, Bagliesi, G, Boccali, T, Calderini, G, Ciulli, V, Foa, L, Giammanco, A, Giassi, A, Ligabue, F, Messineo, A, Palla, E, Rizzo, G, Sanguinetti, G, Sciaba, A, Sguazzoni, G, Steinberger, J, Tenchini, R, Venturi, A, Verdini, Pg, Blair, Ga, Coles, J, Cowan, G, Green, Mg, Jones, Lt, Medcalf, T, Strong, Ja, Clifft, Rw, Edgecock, Tr, Norton, Pr, Tomalin, Ir, Bloch-Devaux, B, Boumediene, D, Colas, P, Fabbro, B, Lancon, E, Lemaire, Mc, Locci, E, Perez, P, Rander, J, Renardy, Jf, Rosowsky, A, Seager, P, Trabelsi, A, Tuchming, B, Vallage, B, Konstantinidis, N, Loomis, C, Litke, Am, Taylor, G, Booth, Cn, Cartwright, S, Combley, F, Hodgson, Pn, Lehto, M, Thompson, Lf, Affholderbach, K, Bohrer, A, Brandt, S, Grupen, C, Hess, J, Misiejuk, A, Prange, G, Sieler, U, Borean, C, Giannini, G, Gobbo, B, He, H, Putz, J, Rothberg, J, Wasserbaech, S, Armstrong, Sr, Cranmer, K, Elmer, P, Ferguson, Dp, Gao, Y, Gonzalez, S, Hayes, Oj, Hu, H, Jin, S, Kile, J, Mcnamara, Pa, Nielsen, J, Orejudos, W, Pan, Yb, Saadi, Y, Scott, Ij, Shao, N, von Wimmersperg-Toeller, Jh, Walsh, J, Wiedenmann, W, Wu, J, Wu, Sl, Wu, X, and Zobernig, G
Subjects: Physics, Nuclear and High Energy Physics, Particle physics, Aleph, Research Groups and Centres\Physics\Low Temperature Physics, 010308 nuclear & particles physics, ENERGIES, Faculty of Science\Physics, Electron–positron annihilation, Detector, High Energy Physics::Phenomenology, FOS: Physical sciences, 01 natural sciences, High Energy Physics - Experiment, Standard Model, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, Higgs boson, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, 010306 general physics, Particle Physics - Experiment
Abstract: A search has been performed for the Standard Model Higgs boson in the data sample collected with the ALEPH detector at LEP, at centre-of-mass energies up to 209GeV. An excess of 3sigma beyond the background expectation is found, consistent with the production of the Higgs boson with a mass near 114GeV/c2. Much of this excess is seen in the four-jet analyses, where three high purity events are selected., Comment: 16 pages, 13 figures
Published: 2000

47. Measurement of Lambda polarization from Z decays

Author: Buskulic, D., de Bonis, I., Decamp, D., Ghez, P., Goy, C., Lees, J.P., Lucotte, A., Minard, M.N., Odier, P., Pietrzyk, B., Chmeissani, M., Crespo, J.M., Delfino, M., Efthymiopoulos, I., Fernandez, E., Fernandez-Bosman, M., Garrido, L., Juste, A., Martinez, M., Orteu, S., Pacheco, A., Padilla, C., Palla, F., Pascual, A., Perlas, J.A., Riu, I., Sanchez, F., Teubert, F., Colaleo, A., Creanza, D., de Palma, M., Farilla, A., Gelao, G., Girone, M., Iaselli, G., Maggi, G., Maggi, M., Marinelli, N., Natali, S., Nuzzo, S., Ranieri, A., Raso, G., Romano, F., Ruggieri, F., Selvaggi, G., Silvestris, L., Tempesta, P., Zito, G., Huang, X., Lin, Jiali, Ouyang, Q., Wang, T., Xie, Y., Xu, R., Xue, S., Zhang, J., Zhang, L., Zhao, W., Alemany, R., Bazarko, A.O., Bonvicini, G., Cattaneo, M., Comas, P., Coyle, P., Drevermann, H., Forty, R.W., Frank, M., Hagelberg, R., Harvey, J., Jacobsen, R., Janot, P., Jost, B., Kneringer, E., Knobloch, J., Lehraus, I., Martin, E.B., Mato, P., Minten, A., Miquel, R., Mir, L.M., Moneta, L., Oest, T., Palazzi, P., Pater, J.R., Pusztaszeri, J.F., Ranjard, F., Rensing, P., Rolandi, L., Schlatter, D., Schmelling, M., Schneider, O., Tejessy, W., Tomalin, I.R., Venturi, A., Wachsmuth, H., Wagner, A., Wildish, T., Witzeling, W., Wotschack, J., Ajaltouni, Ziad, Barres, A., Boyer, Claudine, Falvard, Alain, Gay, Pascal, Guicheney, C., Henrard, Pierre, Jousset, J., Michel, B., Monteil, S., Montret, Jean-Claude, Pallin, D., Perret, Pascal, Podlyski, F., Proriol, Joseph, Rossignol, J.M., Fearnley, T., Hansen, J.B., Hansen, J.D., Hansen, J.R., Hansen, P.H., Nilsson, B.S., Waananen, A., Kyriakis, A., Markou, C., Simopoulou, E., Siotis, I., Vayaki, A., Zachariadou, K., Blondel, A., Bonneaud, G., Brient, J.C., Bourdon, P., Rouge, A., Rumpf, M., Tanaka, R., Valassi, A., Verderi, M., Videau, H., Candlin, D.J., Parsons, M.I., Focardi, E., Parrini, G., Corden, M., Georgiopoulos, C., Jaffe, D.E., Antonelli, A., Bencivenni, G., Bologna, G., Bossi, F., Campana, P., Capon, G., Casper, D., Chiarella, V., Felici, G., Laurelli, P., Mannocchi, G., Murtas, F., Murtas, G.P., Passalacqua, L., Pepe-Altarelli, M., Curtis, L., Dorris, S.J., Halley, A.W., Knowles, I.G., Lynch, J.G., O'Shea, V., Raine, C., Reeves, P., Scarr, J.M., Smith, K., Thompson, A.S., Thomson, F., Thorn, S., Turnbull, R.M., Becker, U., Geweniger, C., Graefe, G., Hanke, P., Hepp, V., Kluge, E.E., Putzer, A., Rensch, B., Schmidt, M., Sommer, J., Stenzel, H., Tittel, K., Werner, S., Wunsch, M., Abbaneo, D., Beuselinck, R., Binnie, D.M., Cameron, W., Dornan, P.J., Moutoussi, A., Nash, J., San Martin, G., Sedgbeer, J.K., Stacey, A.M., Williams, M.D., Dissertori, G., Girtler, P., Kuhn, D., Rudolph, G., Bowdery, C.K., Brodbeck, T.J., Colrain, P., Crawford, G., Finch, A.J., Foster, F., Hughes, G., Sloan, T., Whelan, E.P., Williams, M.I., Galla, A., Greene, A.M., Kleinknecht, K., Quast, G., Renk, B., Rohne, E., Sander, H.G., Wanke, R., van Gemmeren, P., Zeitnitz, C., Aubert, J.J., Bencheikh, A.M., Benchouk, C., Bonissent, A., Bujosa, G., Calvet, D., Carr, J., Diaconu, C., Etienne, F., Konstantinidis, N., Nicod, D., Payre, P., Rousseau, D., Sadouki, A., Talby, M., Thulasidas, M., Trabelsi, Karim, Abt, I., Assmann, R., Bauer, C., Blum, W., Dietl, H., Dydak, F., Ganis, G., Gotzhein, C., Jakobs, K., Kroha, H., Lutjens, G., Lutz, G., Manner, W., Moser, H.G., Richter, R., Rosado-Schlosser, A., Schael, S., Settles, R., Seywerd, H., Wiedenmann, W., Wolf, G., Boucrot, J., Callot, O., Cordier, A., Davier, M., Duflot, L., Grivaz, J.F., Heusse, P., Jacquet, M., Kim, D.W., Le Diberder, F., Lefrancois, J., Lutz, A.M., Nikolic, I., Park, H.J., Park, I.C., Schune, M.H., Simion, S., Veillet, J.J., Videau, I., Azzurri, P., Bagliesi, G., Batignani, G., Bettarini, S., Bozzi, C., Calderini, G., Carpinelli, M., Ciocci, M.A., Ciulli, V., Dell'Orso, R., Fantechi, R., Ferrante, I., Foa, L., Forti, F., Giassi, A., Giorgi, M.A., Gregorio, A., Ligabue, F., Lusiani, A., Marrocchesi, P.S., Messineo, A., Rizzo, G., Sanguinetti, G., Sciaba, A., Spagnolo, P., Steinberger, J., Tenchini, R., Tonelli, G., Vannini, C., Verdini, P.G., Walsh, J., Betteridge, A.P., Blair, G.A., Bryant, L.M., Cerutti, F., Chambers, J.T., Gao, Y., Green, M.G., Johnson, D.L., Medcalf, T., Perrodo, P., Strong, J.A., von Wimmersperg-Toller, J.H., Botterill, D.R., Clifft, R.W., Edgecock, T.R., Haywood, S., Maley, P., Norton, P.R., Thompson, J.C., Bloch-Devaux, B., Colas, P., Emery, S., Kozanecki, W., Lancon, E., Lemaire, M.C., Locci, E., Marx, B., Perez, P., Rander, J., Renardy, J.F., Roussarie, A., Schuller, J.P., Schwindling, J., Trabelsi, A., Vallage, B., Johnson, R.P., Kim, H.Y., Litke, A.M., Mcneil, M.A., Taylor, G., Beddall, A., Booth, C.N., Boswell, R., Brew, C.A.J., Cartwright, S., Combley, F., Koksal, A., Letho, M., Newton, W.M., Rankin, C., Reeve, J., Thompson, L.F., Bohrer, A., Brandt, S., Buscher, V., Cowan, G., Feigl, E., Grupen, C., Lutters, G., Minguet-Rodriguez, J., Rivera, F., Saraiva, P., Smolik, L., Stephan, F., Aleppo, M., Apollonio, N., Bosisio, L., Della Marina, R., Giannini, G., Gobbo, B., Musolino, G., Ragusa, F., Rothberg, J., Wasserbaech, S., Armstrong, S.R., Bellantoni, L., Elmer, P., Feng, Z., Ferguson, D.P.S., Gao, Y.S., Gonzales, S., Grahl, J., Greening, T.C., Harton, J.L., Hayes, O.J., Hu, H., Mcnamara Iii, P.A., Nachtman, J.M., Orejudos, W., Pan, Y.B., Saadi, Y., Schmitt, M., Scott, I.J., Sharma, V., Turk, J.D., Walsh, A.M., Wu, S.L., Wu, X., Yamartino, J.M., Zheng, M., Zobernig, G., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALEPH, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Buskulic, D, Debonis, I, Decamp, D, Ghez, P, Goy, C, Lees, Jp, Lucotte, A, Minard, Mn, Odier, P, Pietrzyk, B, Chmeissani, M, Crespo, Jm, Delfino, M, Efthymiopoulos, I, Fernandez, E, Fernandezbosman, M, Garrido, L, Juste, A, Martinez, M, Orteu, S, Pacheco, A, Padilla, C, Palla, F, Pascual, A, Perlas, Ja, Riu, I, Sanchez, F, Teubert, F, Colaleo, A, Gelao, G, Girone, M, Iaselli, G, Maggi, G, Nuzzo, S, Ranier, A, Raso, G, Romano, F, Ruggieri, E, Selvaggi, G, Silvestris, L, Tempesta, P, Zito, G, Huang, X, Lin, J, Ouyang, Q, Wang, T, Xie, Y, Xu, R, Xue, S, Zhang, J, Zhang, L, Zhao, W, Alemany, R, Bazarko, Ao, Bonvicini, G, Cattaneo, M, Comas, P, Coyle, P, Drevermann, H, Forty, Rw, Frank, M, Hagelberg, R, Harvey, J, Jacobsen, R, Jano, P, Jost, B, Kneringer, E, Knobloch, J, Lehraus, I, Martin, Eb, Mato, P, Minten, A, Miquel, R, Mir, Lm, Moneta, L, Oest, T, Palazzi, P, Pater, Jr, Pusztaszeri, Jf, Ranjard, F, Rensing, P, Rolandi, L, Schlatter, D, Schmelling, M, Schneider, O, Tejessy, W, Tomalin, Ir, Venturi, A, Wachsmuth, H, Wagner, A, Wildish, T, Witzeling, W, Wotschack, J, Ajaltouni, Z, Barres, A, Boyer, C, Falvard, A, Gay, P, Guicheney, C, Henrard, P, Jousset, J, Michel, B, Monteil, S, Montret, Jc, Pallin, D, Perret, P, Podlyski, F, Proriol, J, Rossignol, Jm, Fearnley, T, Hansen, Jb, Hansen, Jd, Hansen, Jr, Hansen, Ph, Nilsson, B, Waananen, A, Kyriakis, A, Markou, C, Simopoulou, E, Siotis, I, Vayaki, A, Zachariadou, K, Blondel, A, Bonneaud, G, Brient, Jc, Bourdon, P, Rouge, A, Rumpf, M, Tanaka, R, Valassi, A, Verderi, M, Videau, H, Candlin, Dj, Parsons, Mi, Focardi, E, Parrini, G, Corden, M, Georgiopoulos, C, Jaffe, De, Antonelli, A, Bencivenni, G, Bologna, G, Bossi, F, Campana, F, Capon, G, Casper, D, Chiarella, V, Felici, G, Laurelli, P, Mannocchi, G, Murtas, F, Murtas, Gp, Passalacqua, L, Pepealtarelli, M, Curtis, L, Dorris, Sj, Halley, Aw, Knowles, Ig, Lynch, Jg, Oshea, V, Raine, C, Reeves, P, Scarr, Jm, Smith, K, Thompson, A, Thomas, F, Thorn, S, Turnbull, Rm, Becker, U, Geweniger, C, Graefe, G, Hanke, P, Hansper, G, Hepp, V, Kluge, Ee, Putzer, A, Rensch, B, Schmidt, M, Sommer, J, Stenzel, H, Tittel, K, Werner, S, Wunsch, M, Abbaneo, D, Beuselinck, R, Binnie, Dm, Cameron, W, Dornan, Pj, Moutoussi, A, Nash, J, Sedgbeer, Jk, Stacey, Am, Williams, Md, Dissertori, G, Girtler, P, Kuhn, D, Rudolph, G, Bowdery, Ck, Brodbeck, Tj, Colrain, P, Crawford, G, Finch, Aj, Foster, F, Hughes, G, Sloan, T, Whelan, Ep, Williams, Mi, Galla, A, Greene, Am, Kleinknecht, K, Quast, G, Renk, B, Rohne, E, Sander, Hg, Vangemmeren, P, Zeitnitz, C, Aubert, Jj, Bencheikh, Am, Benchouk, C, Bonissent, A, Bujosa, G, Calvet, D, Carr, J, Diaconu, C, Etienne, E, Konstantinidis, N, Nicod, D, Payre, P, Rousseau, D, Talby, M, Sadouki, A, Thulasidas, M, Trabelsi, K, Abt, I, Assmann, R, Bauer, C, Blum, W, Dietl, H, Dydak, F, Ganis, G, Gotzhein, C, Jakobs, K, Kroha, H, Lutjens, G, Lutz, G, Manner, W, Moser, Hg, Richter, R, Rosadoschlosser, A, Schael, S, Settles, R, Seywerd, H, Stdenis, R, Wiedenmann, W, Wolf, G, Boucrot, J, Callot, O, Cordier, A, Davier, M, Duflot, L, Grivaz, Jf, Heusse, P, Jacquet, M, Kimfn, Dw, Lediberder, F, Lefrancois, J, Lutz, Am, Nikolic, I, Park, Hj, Park, Ic, Schune, Mh, Simion, S, Veillet, Jj, Videau, I, Azzurri, P, Bagliesi, G, Batignani, G, Bettarini, S, Bozzi, C, Calderini, G, Carpinelli, M, Ciocci, Ma, Ciulli, V, Dellorso, R, Fantechi, R, Ferrante, I, Foa, L, Forti, F, Giassi, A, Giorgi, Ma, Gregorio, A, Ligabue, Franco, Lusiani, Alberto, Marrocchesi, P, Messineo, A, Rizzo, G, Sanguinetti, G, Sciaba, A, Spagnolo, P, Steinberger, J, Tenchini, R, Tonelli, G, Vannini, C, Verdini, Pg, Walsh, J, Betteridge, Ap, Blair, Ga, Bryant, Lm, Cerutti, F, Chambers, Jt, Gao, Y, Green, Mg, Johnson, Dl, Medcalf, T, Perrodo, P, Strong, Ja, Vonwimmerspergtoeller, Jh, Botterill, Dr, Clifft, Rw, Edgecock, Tr, Haywood, S, Maley, P, Norton, Pr, Thompson, Jc, Wright, Ae, Blochdevaux, B, Colas, P, Emery, S, Kozanecki, W, Lancon, E, Lemaire, Mc, Locci, E, Marx, B, Perez, P, Rander, J, Renardy, Jf, Roussarie, A, Schuller, Jp, Schwindling, J, Trabelsi, A, Vallage, B, Johnson, Rp, Kim, Hy, Litke, Am, Mcneil, Ma, Taylor, G, Beddall, A, Booth, Cn, Boswell, R, Brew, Caj, Cartwright, S, Combley, F, Koksal, A, Letho, M, Newton, Wm, Rankin, C, Reeve, J, Thompson, Lf, Bohrer, A, Brandt, S, Buscher, V, Cowan, G, Grupen, C, Lutters, G, Minguetrodriguez, J, Rivera, F, Saraiva, P, Smolik, L, Stephan, F, Aleppo, M, Apollonio, M, Bosisio, L, Dellamarina, R, Giannini, G, Gobbo, B, Musolino, G, Ragusa, F, Rothberg, J, Wasserbaech, S, Armstrong, Sr, Bellantoni, L, Elmer, P, Feng, Z, Ferguson, Dp, Gonzalez, S, Grahl, J, Greening, Tc, Harton, Jl, Hayes, Oj, Hu, H, Mcnamara, Pa, Nachtmana, Jm, Orejudos, W, Pan, Yb, Saadi, Y, Schmitt, M, Scott, Ij, Sharma, V, Turk, Jd, Walsh, Am, Wu, Sl, Wu, X, Yamartino, Jm, Zheng, M, and Zobernig, G.
Subjects: High Energy Physics::Phenomenology, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, Particle Physics - Experiment
Abstract: The polarization of \Lambda baryons from Z decays is studied with the {\sc Aleph} apparatus. Evidence of longitudinal polarization of s quarks from Z decay is observed for the first time. The measured longitudinal \Lambda polarization is P^{\Lambda}_{L} = -0.32 \pm 0.07 for z = p/p_{\mathrm{beam}} > 0.3. This agrees with the prediction of -0.39 \pm 0.08 from the standard model and the constituent quark model, where the error is due to uncertainties in the mechanism for \Lambda production. The observed \Lambda polarization is diluted with respect to the primary s quark polarization by \Lambda baryons without a primary s quark. Measurements of the \Lambda forward-backward asymmetry and of the correlation between back-to-back \Lambda \bar{\Lambda} pairs are used to check this dilution. In addition the transverse \Lambda polarization is measured. An indication of transverse polarization, more than two standard deviations away from zero, is found along the normal to the plane defined by the thrust axis and the \Lambda direction. %
Published: 1996

48. Measurement of Λ polarization from Z decays

Author: D. Buskulic, I. De Bonis, D. Decamp, P. Ghez, C. Goy, J.-P. Lees, A. Lucotte, M.-N. Minard, P. Odier, B. Pietrzyk, M. Chmeissani, J.M. Crespo, M. Delfino, I. Efthymiopoulos, E. Fernandez, M. Fernandez-Bosman, Ll. Garrido, A. Juste, M. Martinez, S. Orteu, A. Pacheco, C. Padilla, F. Palla, A. Pascual, J.A. Perlas, I. Riu, F. Sanchez, F. Teubert, A. Colaleo, D. Creanza, M. de Palma, A. Farilla, G. Gelao, M. Girone, G. Iaselli, G. Maggi, M. Maggi, N. Marinelli, S. Natali, S. Nuzzo, A. Ranieri, G. Raso, F. Romano, F. Ruggieri, G. Selvaggi, L. Silvestris, P. Tempesta, G. Zito, X. Huang, J. Lin, Q. Ouyang, T. Wang, Y. Xie, R. Xu, S. Xue, J. Zhang, L. Zhang, W. Zhao, R. Alemany, A.O. Bazarko, G. Bonvicini, M. Cattaneo, P. Comas, P. Coyle, H. Drevermann, R.W. Forty, M. Frank, R. Hagelberg, J. Harvey, R. Jacobsen, P. Janot, B. Jost, E. Kneringer, J. Knobloch, I. Lehraus, E.B. Martin, P. Mato, A. Minten, R. Miquel, Ll.M. Mir, L. Moneta, T. Oest, P. Palazzi, J.R. Pater, J.-F. Pusztaszeri, F. Ranjard, P. Rensing, L. Rolandi, D. Schlatter, M. Schmelling, O. Schneider, W. Tejessy, I.R. Tomalin, A. Venturi, H. Wachsmuth, A. Wagner, T. Wildish, W. Witzeling, J. Wotschack, Z. Ajlatouni, A. Barrès, C. Boyer, A. Falvard, P. Gay, C. Guicheney, P. Henrard, J. Jousset, B. Michel, S. Monteil, J-C. Montret, D. Pallin, P. Perret, F. Podlyski, J. Proriol, J.-M. Rossignol, T. Fearnley, J.B. Hansen, J.D. Hansen, J.R. Hansen, P.H. Hansen, B.S. Nilsson, A. Wäänänen, A. Kyriakis, C. Markou, E. Simopoulou, I. Siotis, A. Vayaki, K. Zachariadou, A. Blondel, G. Bonneaud, J.C. Brient, P. Bourdon, A. Rougé, M. Rumpf, R. Tanaka, A. Valassi, M. Verderi, H. Videau, D.J. Candlin, M.I. Parsons, E. Focardi, G. Parrini, M. Corden, C. Georgiopoulos, D.E. Jaffe, A. Antonelli, G. Bencivenni, G. Bologna, F. Bossi, P. Campana, G. Capon, D. Casper, V. Chiarella, G. Felici, P. Laurelli, G. Mannocchi, F. Murtas, G.P. Murtas, L. Passalacqua, M. Pepe-Altarelli, L. Curtis, S.J. Dorris, A.W. Halley, I.G. Knowles, J.G. Lynch, V. O'Shea, C. Raine, P. Reeves, J.M. Scarr, K. Smith, A.S. Thompson, F. Thomson, S. Thorn, R.M. Turnbull, U. Becker, C. Geweniger, G. Graefe, P. Hanke, G. Hansper, V. Hepp, E.E. Kluge, A. Putzer, B. Rensch, M. Schmidt, J. Sommer, H. Stenzel, K. Tittel, S. Werner, M. Wunsch, D. Abbaneo, R. Beuselinck, D.M. Binnie, W. Cameron, P.J. Dornan, A. Moutoussi, J. Nash, J.K. Sedgbeer, A.M. Stacey, M.D. Williams, G. Dissertori, P. Girtler, D. Kuhn, G. Rudolph, C.K. Bowdery, T.J. Brodbeck, P. Colrain, G. Crawford, A.J. Finch, F. Foster, G. Hughes, T. Sloan, E.P. Whelan, M.I. Williams, A. Galla, A.M. Greene, K. Kleinknecht, G. Quast, B. Renk, E. Rohne, H.-G. Sander, P. van Gemmeren, C. Zeitnitz, J.J. Aubert, A.M. Bencheikh, C. Benchouk, A. Bonissent, G. Bujosa, D. Calvet, J. Carr, C. Diaconu, F. Etienne, N. Konstantinidis, D. Nicod, P. Payre, D. Rousseau, M. Talby, A. Sadouki, M. Thulasidas, K. Trabelsi, I. Abt, R. Assmann, C. Bauer, W. Blum, H. Dietl, F. Dydak, G. Ganis, C. Gotzhein, K. Jakobs, H. Kroha, G. Lütjens, G. Lutz, W. Männer, H.-G. Moser, R. Richter, A. Rosado-Schlosser, S. Schael, R. Settles, H. Seywerd, R.St. Denis, W. Wiedenmann, G. Wolf, J. Boucrot, O. Callot, A. Cordier, M. Davier, L. Duflot, J.-F. Grivaz, Ph. Heusse, M. Jacquet, D.W. Kim, F. Le Diberder, J. Lefrançois, A.-M. Lutz, I. Nikolic, H.J. Park, I.C. Park, M.-H. Schune, S. Simion, J.-J. Veillet, I. Videau, P. Azzurri, G. Bagliesi, G. Batignani, S. Bettarini, C. Bozzi, G. Calderini, M. Carpinelli, M.A. Ciocci, V. Ciulli, R. Dell'Orso, R. Fantechi, I. Ferrante, L. Foà, F. Forti, A. Giassi, M.A. Giorgi, A. Gregorio, F. Ligabue, A. Lusiani, P.S. Marrocchesi, A. Messineo, G. Rizzo, G. Sanguinetti, A. Sciabà, P. Spagnolo, J. Steinberger, R. Tenchini, G. Tonelli, C. Vannini, P.G. Verdini, J. Walsh, A.P. Betteridge, G.A. Blair, L.M. Bryant, F. Cerutti, J.T. Chambers, Y. Gao, M.G. Green, D.L. Johnson, T. Medcalf, P. Perrodo, J.A. Strong, J.H. von Wimmersperg-Toeller, D.R. Botterill, R.W. Clifft, T.R. Edgecock, S. Haywood, P. Maley, P.R. Norton, J.C. Thompson, A.E. Wright, B. Bloch-Devaux, P. Colas, S. Emery, W. Kozanecki, E. Lançon, M.C. Lemaire, E. Locci, B. Marx, P. Perez, J. Rander, J.-F. Renardy, A. Roussarie, J.-P. Schuller, J. Schwindling, A. Trabelsi, B. Vallage, R.P. Johnson, H.Y. Kim, A.M. Litke, M.A. McNeil, G. Taylor, A. Beddall, C.N. Booth, R. Boswell, C.A.J. Brew, S. Cartwright, F. Combley, A. Koksal, M. Letho, W.M. Newton, C. Rankin, J. Reeve, L.F. Thompson, A. Böhrer, S. Brandt, V. Büscher, G. Cowan, C. Grupen, G. Lutters, J. Minguet-Rodriguez, F. Rivera, P. Saraiva, L. Smolik, F. Stephan, M. Aleppo, M. Apollonio, L. Bosisio, R. Della Marina, G. Giannini, B. Gobbo, G. Musolino, F. Ragusa, J. Rothberg, S. Wasserbaech, S.R. Armstrong, L. Bellantoni, P. Elmer, Z. Feng, D.P.S. Ferguson, Y.S. Gao, S. González, J. Grahl, T.C. Greening, J.L. Harton, O.J. Hayes, H. Hu, P.A. McNamara, J.M. Nachtman, W. Orejudos, Y.B. Pan, Y. Saadi, M. Schmitt, I.J. Scott, V. Sharma, J.D. Turk, A.M. Walsh, Sau Lan Wu, X. Wu, J.M. Yamartino, M. Zheng, G. Zobernig, D., Buskulic, I., De Boni, D., Decamp, P., Ghez, C., Goy, J. P., Lee, A., Lucotte, M. N., Minard, P., Odier, B., Pietrzyk, M., Chmeissani, J. M., Crespo, M., Delfino, I., Efthymiopoulo, E., Fernandez, M., Fernandez Bosman, Garrido, L. l., A., Juste, M., Martinez, S., Orteu, A., Pacheco, C., Padilla, F., Palla, A., Pascual, J. A., Perla, I., Riu, F., Sanchez, F., Teubert, A., Colaleo, D., Creanza, M., de Palma, A., Farilla, G., Gelao, M., Girone, G., Iaselli, G., Maggi, M., Maggi, N., Marinelli, S., Natali, S., Nuzzo, A., Ranieri, G., Raso, F., Romano, F., Ruggieri, G., Selvaggi, L., Silvestri, P., Tempesta, G., Zito, X., Huang, J., Lin, Q., Ouyang, T., Wang, Y., Xie, R., Xu, S., Xue, J., Zhang, L., Zhang, W., Zhao, R., Alemany, A. O., Bazarko, G., Bonvicini, M., Cattaneo, P., Coma, P., Coyle, H., Drevermann, R. W., Forty, M., Frank, R., Hagelberg, J., Harvey, R., Jacobsen, P., Janot, B., Jost, E., Kneringer, J., Knobloch, I., Lehrau, E. B., Martin, P., Mato, A., Minten, R., Miquel, Mir, L. l. M., L., Moneta, T., Oest, P., Palazzi, J. R., Pater, J. F., Pusztaszeri, F., Ranjard, P., Rensing, L., Rolandi, D., Schlatter, M., Schmelling, O., Schneider, W., Tejessy, I. R., Tomalin, A., Venturi, H., Wachsmuth, A., Wagner, T., Wildish, W., Witzeling, J., Wotschack, Z., Ajlatouni, A., Barrè, C., Boyer, A., Falvard, P., Gay, C., Guicheney, P., Henrard, J., Jousset, B., Michel, S., Monteil, J. C., Montret, D., Pallin, P., Perret, F., Podlyski, J., Proriol, J. M., Rossignol, T., Fearnley, J. B., Hansen, J. D., Hansen, J. R., Hansen, P. H., Hansen, B. S., Nilsson, A., Wäänänen, A., Kyriaki, C., Markou, E., Simopoulou, I., Sioti, A., Vayaki, K., Zachariadou, A., Blondel, G., Bonneaud, J. C., Brient, P., Bourdon, A., Rougé, M., Rumpf, R., Tanaka, A., Valassi, M., Verderi, H., Videau, D. J., Candlin, M. 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Subjects: Physics, Quark, Nuclear and High Energy Physics, Strange quark, 010308 nuclear & particles physics, Electron–positron annihilation, Hadron, Constituent quark, Polarization (waves), 01 natural sciences, Baryon, Nuclear physics, ALEPH Experiment, 0103 physical sciences, High Energy Physics::Experiment, 010306 general physics, ALEPH experiment
Abstract: The polarization of Λ baryons from Z decays is studied with the Aleph apparatus. Evidence of longitudinal polarization of s quarks from Z decay is observed for the first time. The measured longitudinal Λ polarization is PLΛ = −0.32 ± 0.07 for z = p p beam > 0.3 . This agrees with the prediction of −0.39 ± 0.08 from the standard model and the constituent quark model, where the error is due to uncertainties in the mechanism for Λ production. The observed Λ polarization is diluted with respect to the primary s quark polarization by Λ baryons without a primary s quark. Measurements of the Λ forward-backward asymmetry and of the correlation between back-to-back Λ Λ pairs are used to check this dilution. In addition the transverse Λ polarization is measured. An indication of transverse polarization, more than two standard deviations away from zero, is found along the normal to the plane defined by the thrust axis and the Λ direction.
Published: 1996

49. LIMIT ON B-S(0) OSCILLATION USING A JET CHARGE METHOD

Author: D. Buskulic, D. Casper, I. De Bonis, D. Decamp, P. Ghez, C. Goy, J.-P. Lees, A. Lucotte, M.-N. Minard, P. Odier, B. Pietrzyk, F. Ariztizabal, M. Chmeissani, J.M. Crespo, I. Efthymiopoulos, E. Fernandez, M. Fernandez-Bosman, V. Gaitan, Ll. Garrido, M. Martinez, S. Orteu, A. Pacheco, C. Padilla, F. Palla, A. Pascual, J.A. Perlas, F. Sanchez, F. Teubert, A. Colaleo, D. Creanza, M. de Palma, A. Farilla, G. Gelao, M. Girone, G. Iaselli, G. Maggi, M. Maggi, N. Marinelli, S. Natali, S. Nuzzo, A. Ranieri, G. Raso, F. Romano, F. Ruggieri, G. Selvaggi, L. Silvestris, P. Tempesta, G. Zito, X. Huang, J. Lin, Q. Ouyang, T. Wang, Y. Xie, R. Xu, S. Xue, J. Zhang, L. Zhang, W. Zhao, G. Bonvicini, D.G. Cassel, M. Cattaneo, P. Comas, P. Coyle, H. Drevermann, A. Engelhardt, R.W. Forty, M. Frank, R. Hagelberg, J. Harvey, R. Jacobsen, P. Janot, B. Jost, J. Knobloch, I. Lehraus, C. Markou, E.B. Martin, P. Mato, T. Mattison, H. Meinhard, A. Minten, R. Miquel, K. Moffeit, T. Oest, P. Palazzi, J.R. Pater, J.-F. Pusztaszeri, F. Ranjard, P. Rensing, L. Rolandi, D. Schlatter, M. Schmelling, O. Schneider, W. Tejessy, I.R. Tomalin, A. Venturi, H. Wachsmuth, W. Wiedenmann, T. Wildish, W. Witzeling, J. Wotschack, Z. Ajaltouni, M. Bardadin-Otwinowska, A. Barres, C. Boyer, A. Falvard, P. Gay, C. Guicheney, P. Henrard, J. Jousset, B. Michel, S. Monteil, J-C. Montret, D. Pallin, P. Perret, F. Podlyski, J. Proriol, J.-M. Rossignol, F. Saadi, T. Fearnley, J.B. Hansen, J.D. Hansen, J.R. Hansen, P.H. Hansen, B.S. Nilsson, A. Kyriakis, E. Simopoulou, I. Siotis, A. Vayaki, K. Zachariadou, A. Blondel, G. Bonneaud, J.C. Brient, P. Bourdon, L. Passalacqua, A. Rougé, M. Rumpf, R. Tanaka, A. Valassi, M. Verderi, H. Videau, D.J. Candlin, M.I. Parsons, E. Focardi, G. Parrini, M. Corden, M. Delfino, C. Georgiopoulos, D.E. Jaffe, A. Antonelli, G. Bencivenni, G. Bologna, F. Bossi, P. Campana, G. Capon, V. Chiarella, G. Felici, P. Laurelli, G. Mannocchi, F. Murtas, G.P. Murtas, M. Pepe-Altarelli, S.J. Dorris, A.W. Halley, I. ten Have, I.G. Knowles, J.G. Lynch, W.T. Morton, V. O'Shea, C. Raine, P. Reeves, J.M. Scarr, K. Smith, M.G. Smith, A.S. Thompson, F. Thomson, S. Thorn, R.M. Turnbull, U. Becker, O. Braun, C. Geweniger, G. Graefe, P. Hanke, V. Hepp, E.E. Kluge, A. Putzer, B. Rensch, M. Schmidt, J. Sommer, H. Stenzel, K. Tittel, S. Werner, M. Wunsch, R. Beuselinck, D.M. Binnie, W. Cameron, D.J. Colling, P.J. Dornan, N. Konstantinidis, L. Moneta, A. Moutoussi, J. Nash, G. San Martin, J.K. Sedgbeer, A.M. Stacey, G. Dissertori, P. Girtler, E. Kneringer, D. Kuhn, G. Rudolph, C.K. Bowdery, T.J. Brodbeck, P. Colrain, G. Crawford, A.J. Finch, F. Foster, G. Hughes, T. Sloan, E.P. Whelan, M.I. Williams, A. Galla, A.M. Greene, K. Kleinknecht, G. Quast, J. Raab, B. Renk, H.-G. Sander, R. Wanke, C. Zeitnitz, J.J. Aubert, A.M. Bencheikh, C. Benchouk, A. Bonissent, G. Bujosa, D. Calvet, J. Carr, C. Diaconu, F. Etienne, M. Thulasidas, D. Nicod, P. Payre, D. Rousseau, M. Talby, I. Abt, R. Assmann, C. Bauer, W. Blum, D. Brown, H. Dietl, F. Dydak, G. Ganis, C. Gotzhein, K. Jakobs, H. Kroha, G. Lütjens, G. Lutz, W. Männer, H.-G. Moser, R. Richter, A. Rosado-Schlosser, A. Schwarz, R. Settles, H. Seywerd, U. Stierlin, R.St. Denis, G. Wolf, R. Alemany, J. Boucrot, O. Callot, A. Cordier, F. Courault, M. Davier, L. Duflot, J.-F. Grivaz, Ph. Heusse, M. Jacquet, D.W. Kim, F. Le Diberder, J. Lefrançois, A.-M. Lutz, G. Musolino, I. Nikolic, H.J. Park, I.C. Park, M.-H. Schune, S. Simion, J.-J. Veillet, I. Videau, D. Abbaneo, P. Azzurri, G. Bagliesi, G. Batignani, S. Bettarini, C. Bozzi, G. Calderini, M. Carpinelli, M.A. Ciocci, V. Ciulli, R. Dell'Orso, R. Fantechi, I. Ferrante, L. Foà, F. Forti, A. Giassi, M.A. Giorgi, A. Gregorio, F. Ligabue, A. Lusiani, P.S. Marrocchesi, A. Messineo, G. Rizzo, G. Sanguinetti, A. Sciabà, P. Spagnolo, J. Steinberger, R. Tenchini, G. Tonelli, G. Triggiani, C. Vannini, P.G. Verdini, J. Walsh, A.P. Betteridge, G.A. Blair, L.M. Bryant, F. Cerutti, Y. Gao, M.G. Green, D.L. Johnson, T. Medcalf, Ll.M. Mir, P. Perrodo, J.A. Strong, V. Bertin, D.R. Botterill, R.W. Clifft, T.R. Edgecock, S. Haywood, M. Edwards, P. Maley, P.R. Norton, J.C. Thompson, B. Bloch-Devaux, P. Colas, H. Duarte, S. Emery, W. Kozanecki, E. Lançon, M.C. Lemaire, E. Locci, B. Marx, P. Perez, J. Rander, J.-F. Renardy, A. Rosowsky, A. Roussarie, J.-P. Schuller, J. Schwindling, D. Si Mohand, A. Trabelsi, B. Vallage, R.P. Johnson, H.Y. Kim, A.M. Litke, M.A. McNeil, G. Taylor, A. Beddall, C.N. Booth, R. Boswell, S. Cartwright, F. Combley, I. Dawson, A. Koksal, M. Letho, W.M. Newton, C. Rankin, L.F. Thompson, A. Böhrer, S. Brandt, G. Cowan, E. Feigl, C. Grupen, G. Lutters, J. Minguet-Rodriguez, F. Rivera, P. Saraiva, L. Smolik, F. Stephan, M. Apollonio, L. Bosisio, R. Della Marina, G. Giannini, B. Gobbo, F. Ragusa, J. Rothberg, S. Wasserbaech, S.R. Armstrong, L. Bellantoni, P. Elmer, Z. Feng, D.P.S. Ferguson, Y.S. Gao, S. González, J. Grahl, J.L. Harton, O.J. Hayes, H. 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I, Knowles, Ig, Lynch, Jg, Smith, Mg, Thompson, A, Thomson, F, Thorn, S, Turnbull, Rm, Becker, U, Braun, O, Geweniger, C, Graefe, G, Hanke, P, Hepp, V, Kluge, Ee, Putzer, A, Rensch, B, Schmidt, M, Sommer, J, Stenzel, H, Tittel, K, Werner, S, Wunsch, M, Beuselinck, R, Binnie, Dm, Cameron, W, Colling, Dj, Dornan, Pj, Konstantinidis, N, Moneta, L, Moutoussi, A, Nash, J, Sanmartin, G, Sedgebeer, Jk, Stacey, Am, Dissertori, G, Girtler, P, Kneringer, E, Kuhn, D, Rudolph, G, Bowdery, Ck, Brodbeck, Tj, Colrain, P, Crawford, G, Finch, Aj, Foster, F, Hughes, G, Sloan, T, Whelan, Ep, Williams, Mi, Galla, A, Greene, Am, Kleinknecht, K, Quast, G, Raab, J, Renk, B, Sander, Hg, Wanke, R, Zeitnitz, C, Aubert, Jj, Bencheikh, Am, Benchouk, C, Bonissent, A, Bujosa, G, Calvet, D, Carr, J, Diaconu, C, Etienne, F, Thulasidas, M, Nicod, D, Payre, P, Rousseau, D, Talby, M, Abt, I, Assman, R, Bauer, C, Blum, W, Brown, D, Dietl, H, Dydak, F, Ganis, G, Gotzhein, C, Jakobs, K, Kroha, H, Lutjens, G, Lutz, G, Manner, W, Moser, Hg, Richter, R, Rosadoschlosser, A, Schwarz, A, Settles, R, Seywerd, H, Stierlin, U, Denis, R, Wolf, G, Alemany, R, Boucrot, J, Callot, O, Cordier, A, Courault, F, Davier, M, Duflot, L, Grivaz, Jf, Heusse, P, Jacquet, M, Kim, Dw, Lediberder, F, Lefrancois, J, Lutz, Am, Musolino, G, Nikolic, I, Park, Ic, Schune, Mh, Simion, S, Veillet, Jj, Videau, I, Abbaneo, D, Azzurri, P, Bagliesi, G, Batignani, G, Bettarini, S, Bozzi, C, Calderini, G, Carpinelli, M, Ciocci, Ma, Ciulli, V, Dellorso, R, Fantechi, R, Ferrante, I, Foa, L, Forti, F, Giassi, A, Giorgi, Ma, Gregorio, A, Ligabue, Franco, Lusiani, Alberto, Marrocchesi, P, Messineo, A, Rizzo, G, Sanguinetti, G, Sciaba, A, Spagnolo, P, Steinberger, J, Tenchini, R, Tonelli, G, Triggiani, G, Vannini, C, Verdini, Pg, Walsh, J, Betteridge, Ap, Blair, Ga, Bryant, Lm, Cerutti, F, Gao, Y, Green, Mg, Johnson, Dl, Medcalf, T, Mir, Lim, Perrodo, P, Strong, Ja, Bertin, V, Botterill, Dr, Clifft, Rw, Edgecock, Tr, Haywood, S, Edwards, M, Maley, P, Norton, Pr, Thompson, Jc, Blochdevaux, B, Colas, P, Duarte, H, Emery, S, Kozanecki, W, Lancon, E, Lemaire, Mc, Locci, E, Marx, B, Perez, P, Rander, J, Renardy, Jf, Rosowsky, A, Roussaire, A, Schuller, Jp, Schwindling, J, Simohand, D, Trabelsi, A, Vallage, B, Johnson, Rp, Kim, Hy, Litke, Am, Mcneil, Ma, Taylor, G, Beddall, A, Booth, Cn, Boswell, R, Cartwright, S, Combley, F, Dawson, I, Koksal, A, Letho, M, Newton, Wm, Rankin, C, Thompson, Lf, Bohrer, A, Brandt, S, Cowan, G, Feigl, E, Grupen, C, Lutters, G, Minguetrodriguez, J, Rivera, F, Saraiva, P, Smolik, L, Stephan, F, Apollonio, M, Bosisio, L, Dellamarina, R, Giannini, G, Gobbo, B, Ragusa, F, Rothberg, J, Wasserbaech, S, Armstrong, Sr, Bellantoni, L, Elmer, P, Feng, Z, Ferguson, Dp, Gonzalez, S, Grahl, J, Harton, Jl, Hayes, Oj, Hu, H, Schmitt, M, Scott, Ij, Sharma, V, Turk, Jd, Walsh, Am, Wu, Sl, Wu, X, Yamartino, Jm, Zheng, M, Zobernig, G, RI ANTONELLI ANTONELLA/C 6238 2011 Passalacqua Luca/F 5127 2011 Murtas Fabrizio/B 5729 2012 Ferrante Isidoro/F 1017 2012 Sanchez Federico/F 5809, 2012, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALEPH, Lees, J, Minard, M, Crespo, J, Garrido, L, Perlas, J, Cassel, D, Forty, R, Martin, E, Pater, J, Pusztaszeri, J, Rolandi, L, Tomalin, I, Montret, J, Rossignol, J, Hansen, J, Hansen, P, Brient, J, Candlin, D, Parsons, M, Jaffe, D, Murtas, G, Dorris, S, Halley, A, Knowles, I, Lynch, J, Smith, M, Turnbull, R, Kluge, E, Binnie, D, Colling, D, Dornan, P, Sedgebeer, J, Stacey, A, Bowdery, C, Brodbeck, T, Finch, A, Whelan, E, Williams, M, Greene, A, Sander, H, Aubert, J, Bencheikh, A, Moser, H, Grivaz, J, Kim, D, Lutz, A, Park, I, Schune, M, Veillet, J, Ciocci, M, Giorgi, M, Ligabue, F, Lusiani, A, Verdini, P, Betteridge, A, Blair, G, Bryant, L, Green, M, Johnson, D, Mir, L, Strong, J, Botterill, D, Clifft, R, Edgecock, T, Norton, P, Thompson, J, Lemaire, M, Renardy, J, Schuller, J, Johnson, R, Kim, H, Litke, A, Mcneil, M, Booth, C, Newton, W, Thompson, L, Armstrong, S, Ferguson, D, Harton, J, Hayes, O, Scott, I, Turk, J, Walsh, A, Wu, S, Yamartino, J, D., Buskulic, D., Casper, I., De Boni, D., Decamp, P., Ghez, C., Goy, J. P., Lee, A., Lucotte, M. N., Minard, P., Odier, B., Pietrzyk, F., Ariztizabal, M., Chmeissani, J. M., Crespo, I., Efthymiopoulo, E., Fernandez, M., Fernandez Bosman, V., Gaitan, Garrido, L. l., M., Martinez, S., Orteu, A., Pacheco, C., Padilla, F., Palla, A., Pascual, J. A., Perla, F., Sanchez, F., Teubert, A., Colaleo, D., Creanza, M., de Palma, A., Farilla, G., Gelao, M., Girone, G., Iaselli, G., Maggi, M., Maggi, N., Marinelli, S., Natali, S., Nuzzo, A., Ranieri, G., Raso, F., Romano, F., Ruggieri, G., Selvaggi, L., Silvestri, P., Tempesta, G., Zito, X., Huang, J., Lin, Q., Ouyang, T., Wang, Y., Xie, R., Xu, S., Xue, J., Zhang, L., Zhang, W., Zhao, G., Bonvicini, D. G., Cassel, M., Cattaneo, P., Coma, P., Coyle, H., Drevermann, A., Engelhardt, R. W., Forty, M., Frank, R., Hagelberg, J., Harvey, R., Jacobsen, P., Janot, B., Jost, J., Knobloch, I., Lehrau, C., Markou, E. B., Martin, P., Mato, T., Mattison, H., Meinhard, A., Minten, R., Miquel, K., Moffeit, T., Oest, P., Palazzi, J. R., Pater, J. F., Pusztaszeri, F., Ranjard, P., Rensing, L., Rolandi, D., Schlatter, M., Schmelling, O., Schneider, W., Tejessy, I. R., Tomalin, A., Venturi, H., Wachsmuth, W., Wiedenmann, T., Wildish, W., Witzeling, J., Wotschack, Z., Ajaltouni, M., Bardadin Otwinowska, A., Barre, C., Boyer, A., Falvard, P., Gay, C., Guicheney, P., Henrard, J., Jousset, B., Michel, S., Monteil, J. C., Montret, D., Pallin, P., Perret, F., Podlyski, J., Proriol, J. M., Rossignol, F., Saadi, T., Fearnley, J. B., Hansen, J. D., Hansen, J. R., Hansen, P. H., Hansen, B. S., Nilsson, A., Kyriaki, E., Simopoulou, I., Sioti, A., Vayaki, K., Zachariadou, A., Blondel, G., Bonneaud, J. C., Brient, P., Bourdon, L., Passalacqua, A., Rougé, M., Rumpf, R., Tanaka, A., Valassi, M., Verderi, H., Videau, D. J., Candlin, M. I., Parson, E., Focardi, G., Parrini, M., Corden, M., Delfino, C., Georgiopoulo, D. E., Jaffe, A., Antonelli, G., Bencivenni, G., Bologna, F., Bossi, P., Campana, G., Capon, V., Chiarella, G., Felici, P., Laurelli, G., Mannocchi, F., Murta, G. P., Murta, M., Pepe Altarelli, S. J., Dorri, A. W., Halley, I., ten Have, I. G., Knowle, J. G., Lynch, W. T., Morton, V., O'Shea, C., Raine, P., Reeve, J. M., Scarr, K., Smith, M. G., Smith, A. S., Thompson, F., Thomson, S., Thorn, R. M., Turnbull, U., Becker, O., Braun, C., Geweniger, G., Graefe, P., Hanke, V., Hepp, E. E., Kluge, A., Putzer, B., Rensch, M., Schmidt, J., Sommer, H., Stenzel, K., Tittel, S., Werner, M., Wunsch, R., Beuselinck, D. M., Binnie, W., Cameron, D. J., Colling, P. J., Dornan, N., Konstantinidi, L., Moneta, A., Moutoussi, J., Nash, G., San Martin, J. K., Sedgbeer, A. M., Stacey, G., Dissertori, P., Girtler, E., Kneringer, D., Kuhn, G., Rudolph, C. K., Bowdery, T. J., Brodbeck, P., Colrain, G., Crawford, A. J., Finch, F., Foster, G., Hughe, T., Sloan, E. P., Whelan, M. I., William, A., Galla, A. M., Greene, K., Kleinknecht, G., Quast, J., Raab, B., Renk, H. G., Sander, R., Wanke, C., Zeitnitz, J. J., Aubert, A. M., Bencheikh, C., Benchouk, A., Bonissent, G., Bujosa, D., Calvet, J., Carr, C., Diaconu, F., Etienne, M., Thulasida, D., Nicod, P., Payre, D., Rousseau, M., Talby, I., Abt, R., Assmann, C., Bauer, W., Blum, D., Brown, H., Dietl, F., Dydak, G., Gani, C., Gotzhein, K., Jakob, H., Kroha, G., Lütjen, G., Lutz, W., Männer, H. G., Moser, R., Richter, A., Rosado Schlosser, A., Schwarz, R., Settle, H., Seywerd, U., Stierlin, Denis, R. S. t., G., Wolf, R., Alemany, J., Boucrot, O., Callot, A., Cordier, F., Courault, M., Davier, L., Duflot, J. F., Grivaz, Heusse, P. h., M., Jacquet, D. W., Kim, F., Le Diberder, J., Lefrançoi, A. M., Lutz, G., Musolino, I., Nikolic, H. J., Park, I. C., Park, M. H., Schune, S., Simion, J. J., Veillet, I., Videau, D., Abbaneo, P., Azzurri, G., Bagliesi, G., Batignani, S., Bettarini, C., Bozzi, G., Calderini, M., Carpinelli, M. A., Ciocci, V., Ciulli, R., Dell'Orso, R., Fantechi, I., Ferrante, L., Foà, F., Forti, A., Giassi, M. A., Giorgi, Gregorio, Anna, F., Ligabue, A., Lusiani, P. S., Marrocchesi, A., Messineo, G., Rizzo, G., Sanguinetti, A., Sciabà, P., Spagnolo, J., Steinberger, R., Tenchini, G., Tonelli, G., Triggiani, C., Vannini, P. G., Verdini, J., Walsh, A. P., Betteridge, G. A., Blair, L. M., Bryant, F., Cerutti, Y., Gao, M. G., Green, D. L., Johnson, T., Medcalf, Mir, L. l. M., P., Perrodo, J. A., Strong, V., Bertin, D. R., Botterill, R. W., Clifft, T. R., Edgecock, S., Haywood, M., Edward, P., Maley, P. R., Norton, J. C., Thompson, B., Bloch Devaux, P., Cola, H., Duarte, S., Emery, W., Kozanecki, E., Lançon, M. C., Lemaire, E., Locci, B., Marx, P., Perez, J., Rander, J. F., Renardy, A., Rosowsky, A., Roussarie, J. P., Schuller, J., Schwindling, D., Si Mohand, A., Trabelsi, B., Vallage, R. P., Johnson, H. Y., Kim, A. M., Litke, M. A., Mcneil, G., Taylor, A., Beddall, C. N., Booth, R., Boswell, S., Cartwright, F., Combley, I., Dawson, A., Koksal, M., Letho, W. M., Newton, C., Rankin, L. F., Thompson, A., Böhrer, S., Brandt, G., Cowan, E., Feigl, C., Grupen, G., Lutter, J., Minguet Rodriguez, F., Rivera, P., Saraiva, L., Smolik, F., Stephan, M., Apollonio, Bosisio, Luciano, R., Della Marina, Giannini, Gianrossano, B., Gobbo, F., Ragusa, J., Rothberg, S., Wasserbaech, S. R., Armstrong, L., Bellantoni, P., Elmer, Z., Feng, D. P. S., Ferguson, Y. S., Gao, S., González, J., Grahl, J. L., Harton, O. J., Haye, H., Hu, P. A., Mcnamara, J. M., Nachtman, W., Orejudo, Y. B., Pan, Y., Saadi, M., Schmitt, I. J., Scott, V., Sharma, J. D., Turk, A. M., Walsh, Sau Lan, Wu, X., Wu, J. M., Yamartino, M., Zheng, G., Zobernig, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)
Subjects: Physics, Nuclear and High Energy Physics, Antiparticle, Particle physics, Meson, 010308 nuclear & particles physics, Electron–positron annihilation, Hadron, High Energy Physics::Phenomenology, 01 natural sciences, Nuclear physics, ALEPH Experiment, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], CP violation, B meson, High Energy Physics::Experiment, 010306 general physics, ALEPH experiment, Particle Physics - Experiment, Lepton
Abstract: A lower limit is set on the B_{s}^{0} meson oscillation parameter \Delta m_{s} using data collected from 1991 to 1994 by the ALEPH detector. Events with a high transverse momentum lepton and a reconstructed secondary vertex are used. The high transverse momentum leptons are produced mainly by b hadron decays, and the sign of the lepton indicates the particle/antiparticle final state in decays of neutral B mesons. The initial state is determined by a jet charge technique using both sides of the event. A maximum likelihood method is used to set a lower limit of \, \Delta m_{s}. The 95\% confidence level lower limit on \Delta m_s ranges between 5.2 and 6.5(\hbar/c^{2})~ps^{-1} when the fraction of b quarks from Z^0 decays that form B_{s}^{0} mesons is varied from 8\% to 16\%. Assuming that the B_{s}^{0} fraction is 12\%, the lower limit would be \Delta m_{s} > 6.1(\hbar/c^{2})~ps^{-1} at 95\% confidence level. For x_s = \Delta m_s \, \tau_{B_s}, this limit also gives x_s > 8.8 using the B_{s}^{0} lifetime of \tau_{B_s} = 1.55 \pm 0.11~ps and shifting the central value of \tau_{B_s} down by 1\sigma.
Published: 1995

50. HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases.

Author: Ruggieri E, Di Domenico E, Locatelli AG, Isopo F, Damanti S, De Lorenzo R, Milan E, Musco G, Rovere-Querini P, Cenci S, and Vénéreau E
Abstract: Aging is a universal biological process characterized by a progressive, cumulative decline in homeostatic capabilities and physiological functions, which inevitably increases vulnerability to diseases. A number of molecular pathomechanisms and hallmarks of aging have been recognized, yet we miss a thorough understanding of their complex interconnectedness. This review explores the molecular and cellular mechanisms underlying human aging, with a focus on the multiple roles of high mobility group Box 1 protein (HMGB1), the archetypal damage-associated molecular pattern (DAMP) molecule. In the nucleus, this non-histone chromatin-associated protein functions as a DNA chaperone and regulator of gene transcription, influencing DNA structure and gene expression. Moreover, this versatile protein can translocate to the cytoplasm to orchestrate other processes, such as autophagy, or be unconventionally secreted into the extracellular environment, where it acts as a DAMP, combining inflammatory and regenerative properties. Notably, lower expression of HMGB1 within the cell and its heightened extracellular release have been associated with diverse age-associated traits, making it a suitable candidate as a universal biomarker of aging. In this review, we outline the evidence implicating HMGB1 in aging, also in light of an evolutionary perspective on its functional pleiotropy, and propose critical issues that need to be addressed to gauge the value of HMGB1 as a potential biomarker across age-related diseases and therapeutic target to promote healthy longevity., Competing Interests: Declaration of Competing Interest The authors have nothing to declare., (Copyright © 2024 Elsevier B.V. All rights reserved.)
Published: 2024
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