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5. State of the Science: The Hierarchical Taxonomy of Psychopathology (HiTOP)

Author

Cicero, David C., Ruggero, Camilo J., Balling, Caroline E., Bottera, Angeline R., Cheli, Simone, Elkrief, Laurent, Forbush, Kelsie T., Hopwood, Christopher J., Jonas, Katherine G., Jutras-Aswad, Didier, Kotov, Roman, Levin-Aspenson, Holly F., Mullins-Sweatt, Stephanie N., Johnson-Munguia, Sara, Narrow, William E., Negi, Sonakshi, Patrick, Christopher J., Rodriguez-Seijas, Craig, Sheth, Shreya, Simms, Leonard J., and Thomeczek, Marianna L.

Published
2024
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7. Racial/ethnic variations in inflammatory markers: exploring the role of sleep duration and sleep efficiency

Author

Farmer, Heather R., Slavish, Danica C., Ruiz, John, Dietch, Jessica R., Ruggero, Camilo J., Messman, Brett A., and Kelly, Kimberly

Subjects
Minorities -- Health aspects, Inflammation -- Risk factors -- Demographic aspects, Health care disparities -- Demographic aspects, Sleep -- Health aspects, Psychology and mental health
Abstract

Individuals from minoritized racial/ethnic groups have higher levels of circulating inflammatory markers. However, the mechanisms underlying these differences remain understudied. The objective of this study was to examine racial/ethnic variations in multiple markers of inflammation and whether impaired sleep contributes to these racial/ethnic differences. Nurses from two regional hospitals in Texas (n = 377; 71.62% White; 6.90% Black; 11.14% Hispanic, 10.34% Asian; mean age = 39.46; 91.78% female) completed seven days of sleep diaries and actigraphy to assess mean and variability in total sleep time (TST) and sleep efficiency (SE). On day 7, blood was drawn to assess 4 inflammatory markers: C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-1 beta (IL-1[beta]), and tumor necrosis factor-alpha (TNF-[alpha]). Results from regression models showed differences in inflammatory markers by race/ethnicity, adjusting for age and gender. The associations between sleep parameters and inflammatory markers also varied by race/ethnicity. Among White nurses, lower mean and greater variability in actigraphy-determined TST and greater variability in diary-determined TST were associated with higher levels of IL-6. Among Black nurses, lower mean diary-determined SE was associated with higher levels of IL-6 and IL-1[beta]. Among Hispanic nurses, greater diary-determined mean TST was associated with higher CRP. Among Asian nurses, greater intraindividual variability in actigraphy-determined SE was associated with lower CRP. Among nurses, we did not find racial/ethnic disparities in levels of inflammation. However, analyses revealed differential relationships between sleep and inflammatory markers by race/ethnicity. Results highlight the importance of using a within-group approach to understand predictors of inflammatory markers., Author(s): Heather R. Farmer [sup.1] , Danica C. Slavish [sup.2] , John Ruiz [sup.3] , Jessica R. Dietch [sup.4] , Camilo J. Ruggero [sup.2] , Brett A. Messman [sup.2] , [...]

Published
2022
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8. Anxiety sensitivity and Pain Experience: a prospective investigation among World Trade Center Responders

Author

Rogers, Andrew H., Zvolensky, Michael J., Vujanovic, Anka A., Ruggero, Camilo J., Oltmanns, Joshua, Waszczuk, Monika A., and Luft, Benjamin J.

Subjects
Chronic pain -- Risk factors -- Demographic aspects -- Development and progression, First responders -- Psychological aspects -- Health aspects, Anxiety -- Complications and side effects -- Demographic aspects, Stress (Psychology) -- Health aspects -- Demographic aspects, Psychology and mental health
Abstract

Chronic pain is a significant public health problem and is exacerbated by stress. The World Trade Center (WTC) Disaster represents a unique stressor, and responders to the WTC disaster are at increased risk for pain and other health complaints. Therefore, there is a significant need to identify vulnerability factors for exacerbated pain experience among this high-risk population. Anxiety sensitivity (AS), defined as fear of anxiety-related sensations, is one such vulnerability factor associated with pain intensity and disability. Yet, no work has tested the predictive effects of AS on pain, limiting conclusions regarding the predictive utility and direction of associations. Therefore, the current study examined the prospective associations of AS, pain intensity, and pain interference among 452 (M.sub.age = 55.22, SD = 8.73, 89.4% male) responders to the WTC disaster completing a 2-week daily diary study. Using multi-level modeling, AS total score was positively associated with both pain intensity and pain interference, and that AS cognitive concerns, but not social or physical concerns, were associated with increased pain. These results highlight the importance of AS as a predictor of pain complaints among WTC responders and provide initial empirical evidence to support AS as a clinical target for treating pain complaints among WTC responders., Author(s): Andrew H. Rogers [sup.1] , Michael J. Zvolensky [sup.1] [sup.2] [sup.3] , Anka A. Vujanovic [sup.1] , Camilo J. Ruggero [sup.4] , Joshua Oltmanns [sup.5] , Monika A. Waszczuk [...]

Published
2022
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9. Commentary on "The Challenge of Transforming the Diagnostic System of Personality Disorders".

Author

Hopwood, Christopher J, Krueger, Robert F, Watson, David, Widiger, Thomas A, Althoff, Robert R, Ansell, Emily B, Bach, Bo, Bagby, R Michael, Blais, Mark A, Bornovalova, Marina A, Chmielewski, Michael, Cicero, David C, Conway, Christopher, De Clerq, Barbara, De Fruyt, Filip, Docherty, Anna R, Eaton, Nicholas R, Edens, John F, Forbes, Miriam K, Forbush, Kelsie T, Hengartner, Michael P, Ivanova, Masha Y, Leising, Daniel, Lukowitsky, Mark R, Lynam, Donald R, Markon, Kristian E, Miller, Joshua D, Morey, Leslie C, Mullins-Sweatt, Stephanie N, Ormel, Johan, Patrick, Christopher J, Pincus, Aaron L, Ruggero, Camilo, Samuel, Douglas B, Sellbom, Martin, Tackett, Jennifer L, Thomas, Katherine M, Trull, Timothy J, Vachon, David D, Waldman, Irwin D, Waszczuk, Monika A, Waugh, Mark H, Wright, Aidan GC, Yalch, Mathew M, Zald, David H, and Zimmermann, Johannes

Subjects
Psychology, Clinical and Health Psychology, Social and Personality Psychology, Applied and Developmental Psychology, Psychiatry, Applied and developmental psychology, Clinical and health psychology, Social and personality psychology
Published
2020

10. Integrating the Hierarchical Taxonomy of Psychopathology (HiTOP) Into Clinical Practice

Author

Ruggero, Camilo J, Kotov, Roman, Hopwood, Christopher J, First, Michael, Clark, Lee Anna, Skodol, Andrew E, Mullins-Sweatt, Stephanie N, Patrick, Christopher J, Bach, Bo, Cicero, David C, Docherty, Anna, Simms, Leonard J, Bagby, R Michael, Krueger, Robert F, Callahan, Jennifer L, Chmielewski, Michael, Conway, Christopher C, De Clercq, Barbara, Dornbach-Bender, Allison, Eaton, Nicholas R, Forbes, Miriam K, Forbush, Kelsie T, Haltigan, John D, Miller, Joshua D, Morey, Leslie C, Patalay, Praveetha, Regier, Darrel A, Reininghaus, Ulrich, Shackman, Alexander J, Waszczuk, Monika A, Watson, David, Wright, Aidan GC, and Zimmermann, Johannes

Subjects
Health Services, Mental Health, Clinical Research, Brain Disorders, Good Health and Well Being, Adolescent, Adult, Humans, Mental Disorders, Models, Theoretical, Psychopathology, classification, diagnosis, nosology, psychopathology, treatment, Psychology, Clinical Psychology
Abstract

ObjectiveDiagnosis is a cornerstone of clinical practice for mental health care providers, yet traditional diagnostic systems have well-known shortcomings, including inadequate reliability, high comorbidity, and marked within-diagnosis heterogeneity. The Hierarchical Taxonomy of Psychopathology (HiTOP) is a data-driven, hierarchically based alternative to traditional classifications that conceptualizes psychopathology as a set of dimensions organized into increasingly broad, transdiagnostic spectra. Prior work has shown that using a dimensional approach improves reliability and validity, but translating a model like HiTOP into a workable system that is useful for health care providers remains a major challenge.MethodThe present work outlines the HiTOP model and describes the core principles to guide its integration into clinical practice.ResultsPotential advantages and limitations of the HiTOP model for clinical utility are reviewed, including with respect to case conceptualization and treatment planning. A HiTOP approach to practice is illustrated and contrasted with an approach based on traditional nosology. Common barriers to using HiTOP in real-world health care settings and solutions to these barriers are discussed.ConclusionsHiTOP represents a viable alternative to classifying mental illness that can be integrated into practice today, although research is needed to further establish its utility. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Published
2019

15. A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research

Author

Conway, Christopher C, Forbes, Miriam K, Forbush, Kelsie T, Fried, Eiko I, Hallquist, Michael N, Kotov, Roman, Mullins-Sweatt, Stephanie N, Shackman, Alexander J, Skodol, Andrew E, South, Susan C, Sunderland, Matthew, Waszczuk, Monika A, Zald, David H, Afzali, Mohammad H, Bornovalova, Marina A, Carragher, Natacha, Docherty, Anna R, Jonas, Katherine G, Krueger, Robert F, Patalay, Praveetha, Pincus, Aaron L, Tackett, Jennifer L, Reininghaus, Ulrich, Waldman, Irwin D, Wright, Aidan GC, Zimmermann, Johannes, Bach, Bo, Bagby, R Michael, Chmielewski, Michael, Cicero, David C, Clark, Lee Anna, Dalgleish, Tim, DeYoung, Colin G, Hopwood, Christopher J, Ivanova, Masha Y, Latzman, Robert D, Patrick, Christopher J, Ruggero, Camilo J, Samuel, Douglas B, Watson, David, and Eaton, Nicholas R

Subjects
Psychology, Social and Personality Psychology, Applied and Developmental Psychology, Mental Health, Brain Disorders, Behavioral and Social Science, Mental health, Good Health and Well Being, Heuristics, Humans, Mental Disorders, Models, Theoretical, Research Design, Terminology as Topic, mental illness, nosology, individual differences, transdiagnostic, Hierarchical Taxonomy of Psychopathology, HiTOP, ICD, DSM, RDoC, Cognitive Sciences, Social Psychology
Abstract

For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of mental illness. Here we outline one such dimensional system-the Hierarchical Taxonomy of Psychopathology (HiTOP)-that is based on empirical patterns of co-occurrence among psychological symptoms. We highlight key ways in which this framework can advance mental-health research, and we provide some heuristics for using HiTOP to test theories of psychopathology. We then review emerging evidence that supports the value of a hierarchical, dimensional model of mental illness across diverse research areas in psychological science. These new data suggest that the HiTOP system has the potential to accelerate and improve research on mental-health problems as well as efforts to more effectively assess, prevent, and treat mental illness.

Published
2019

16. Commentary on "The Challenge of Transforming the Diagnostic System of Personality Disorders".

Author

Hopwood, Christopher J, Krueger, Robert F, Watson, David, Widiger, Thomas A, Althoff, Robert R, Ansell, Emily B, Bach, Bo, Bagby, R Michael, Blais, Mark A, Bornovalova, Marina A, Chmielewski, Michael, Cicero, David C, Conway, Christopher, De Clerq, Barbara, De Fruyt, Filip, Docherty, Anna R, Eaton, Nicholas R, Edens, John F, Forbes, Miriam K, Forbush, Kelsie T, Hengartner, Michael P, Ivanova, Masha Y, Leising, Daniel, Lukowitsky, Mark R, Lynam, Donald R, Markon, Kristian E, Miller, Joshua D, Morey, Leslie C, Mullins-Sweatt, Stephanie N, Ormel, Johan, Patrick, Christopher J, Pincus, Aaron L, Ruggero, Camilo, Samuel, Douglas B, Sellbom, Martin, Tackett, Jennifer L, Thomas, Katherine M, Trull, Timothy J, Vachon, David D, Waldman, Irwin D, Waszczuk, Monika A, Waugh, Mark H, Wright, Aidan GC, Yalch, Mathew M, Zald, David H, and Zimmermann, Johannes

Subjects
Psychology, Psychiatry
Published
2019

17. Psychometric Evaluation of the Insomnia Severity Index in Nurses.

Author

Nagy, Samantha M., Emert, Sarah E., Leete, Jacqueline J., Taylor, Daniel J., Dietch, Jessica R., Slavish, Danica C., Ruggero, Camilo J., and Kelly, Kimberly

Subjects
PERCEIVED Stress Scale, PSYCHOMETRICS, SLEEP quality, CONFIRMATORY factor analysis, TEST validity
Abstract

Objectives: Examine psychometric properties of the Insomnia Severity Index (ISI) in a sample of nurses. Method: In a sample of day shift nurses (N = 289), a confirmatory factor analysis (CFA), convergent and discriminant validity analyses, and a test–retest reliability analysis were performed. Results: CFA showed that a two-factor model provided the best fit. The ISI had moderate to poor convergent validity with sleep diary parameters, and moderate convergent validity with the Sleep Condition Indicator (r = -.66), Pittsburgh Sleep Quality Index (r =.66), and PROMIS Sleep-Related Impairment measure (r =.67). The ISI demonstrated good discriminant validity with the measures Composite Scale of Morningness (r = −.27), Nightmares Disorder Index (r =.25), PTSD Checklist for DSM-5 (sleep items removed; r =.32), and Perceived Stress Scale (r =.43). The ISI had weaker discriminant validity with the PHQ-9 (r =.69) and Generalized Anxiety Disorder Screener (r =.51). The ISI demonstrated a good test–retest reliability (ICCs =.74–.88). Conclusions: The ISI is a psychometrically strong measure for the assessment of insomnia severity in day shift nurses. Overlap with psychological symptoms, primarily anxiety and depression, suggests caution while interpreting these constructs. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative.

Author

Docherty, Anna R, Fonseca-Pedrero, Eduardo, Debbané, Martin, Chan, Raymond CK, Linscott, Richard J, Jonas, Katherine G, Cicero, David C, Green, Melissa J, Simms, Leonard J, Mason, Oliver, Watson, David, Ettinger, Ulrich, Waszczuk, Monika, Rapp, Alexander, Grant, Phillip, Kotov, Roman, DeYoung, Colin G, Ruggero, Camilo J, Eaton, Nicolas R, Krueger, Robert F, Patrick, Christopher, Hopwood, Christopher, O’Neill, F Anthony, Zald, David H, Conway, Christopher C, Adkins, Daniel E, Waldman, Irwin D, van Os, Jim, Sullivan, Patrick F, Anderson, John S, Shabalin, Andrey A, Sponheim, Scott R, Taylor, Stephan F, Grazioplene, Rachel G, Bacanu, Silviu A, Bigdeli, Tim B, Haenschel, Corinna, Malaspina, Dolores, Gooding, Diane C, Nicodemus, Kristin, Schultze-Lutter, Frauke, Barrantes-Vidal, Neus, Mohr, Christine, Carpenter, William T, and Cohen, Alex S

Subjects
Brain Disorders, Human Genome, Genetics, Mental Health, Good Health and Well Being, Datasets as Topic, Humans, Information Dissemination, Intersectoral Collaboration, Models, Theoretical, Psychotic Disorders, Schizophrenia, Schizotypal Personality Disorder, data sharing, schizotypy, schizotypal, psychos is, schizophrenia, phenotype, genetic, ICSR, HiTOP, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

The latent structure of schizotypy and psychosis-spectrum symptoms remains poorly understood. Furthermore, molecular genetic substrates are poorly defined, largely due to the substantial resources required to collect rich phenotypic data across diverse populations. Sample sizes of phenotypic studies are often insufficient for advanced structural equation modeling approaches. In the last 50 years, efforts in both psychiatry and psychological science have moved toward (1) a dimensional model of psychopathology (eg, the current Hierarchical Taxonomy of Psychopathology [HiTOP] initiative), (2) an integration of methods and measures across traits and units of analysis (eg, the RDoC initiative), and (3) powerful, impactful study designs maximizing sample size to detect subtle genomic variation relating to complex traits (the Psychiatric Genomics Consortium [PGC]). These movements are important to the future study of the psychosis spectrum, and to resolving heterogeneity with respect to instrument and population. The International Consortium of Schizotypy Research is composed of over 40 laboratories in 12 countries, and to date, members have compiled a body of schizotypy- and psychosis-related phenotype data from more than 30000 individuals. It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum. The authors present a data-sharing infrastructure similar to that of the PGC, and a resource-sharing infrastructure similar to that of HiTOP. This report details the rationale and benefits of the phenotypic data collective and presents an open invitation for participation.

Published
2018

20. The time has come for dimensional personality disorder diagnosis

Author

Hopwood, Christopher J, Kotov, Roman, Krueger, Robert F, Watson, David, Widiger, Thomas A, Althoff, Robert R, Ansell, Emily B, Bach, Bo, Bagby, R Michael, Blais, Mark A, Bornovalova, Marina A, Chmielewski, Michael, Cicero, David C, Conway, Christopher, De Clercq, Barbara, De Fruyt, Filip, Docherty, Anna R, Eaton, Nicholas R, Edens, John F, Forbes, Miriam K, Forbush, Kelsie T, Hengartner, Michael P, Ivanova, Masha Y, Leising, Daniel, Livesley, W John, Lukowitsky, Mark R, Lynam, Donald R, Markon, Kristian E, Miller, Joshua D, Morey, Leslie C, Mullins‐Sweatt, Stephanie N, Ormel, J Hans, Patrick, Christopher J, Pincus, Aaron L, Ruggero, Camilo, Samuel, Douglas B, Sellbom, Martin, Slade, Tim, Tackett, Jennifer L, Thomas, Katherine M, Trull, Timothy J, Vachon, David D, Waldman, Irwin D, Waszczuk, Monika A, Waugh, Mark H, Wright, Aidan GC, Yalch, Mathew M, Zald, David H, and Zimmermann, Johannes

Subjects
Biomedical and Clinical Sciences, Clinical and Health Psychology, Social and Personality Psychology, Clinical Sciences, Psychology, Humans, International Classification of Diseases, Personality Disorders, Public Health and Health Services, Clinical sciences, Clinical and health psychology, Social and personality psychology
Published
2018

22. State of the Science: The Hierarchical Taxonomy of Psychopathology (HiTOP)

Author

Cicero, David C, primary, Ruggero, Camilo, additional, Balling, Caroline, additional, Bottera, Angeline R., additional, Cheli, Simone, additional, Elkrief, Laurent, additional, Forbush, Kelsie T., additional, Hopwood, Christopher James, additional, Jonas, Katherine, additional, Jutras-Aswad, Didier, additional, Kotov, Roman, additional, Levin-Aspenson, Holly Frances, additional, Mullins-Sweatt, Stephanie, additional, Johnson-Munguia, Sara, additional, Narrow, William, additional, Negi, Sonakshi, additional, Patrick, Christopher, additional, Rodriguez-Seijas, Craig Anthony, additional, Sheth, Shreya, additional, Simms, Leonard, additional, and Thomeczek, Marianna L., additional

Published
2024
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25. Les progrès dans la réalisation de la classification quantitative de la psychopathologie

Author

Krueger, Robert F., Kotov, Roman, Watson, David, Forbes, Miriam K., Eaton, Nicholas R., Ruggero, Camilo J., Simms, Leonard J., Widiger, Thomas A., Achenbach, Thomas M., Bach, Bo, Bagby, R. Michael, Bornovalova, Marina A., Carpenter, William T., Chmielewski, Michael, Cicero, David C., Clark, Lee Anna, Conway, Christopher, DeClercq, Barbara, DeYoung, Colin G., Docherty, Anna R., Drislane, Laura E., First, Michael B., Forbush, Kelsie T., Hallquist, Michael, Haltigan, John D., Hopwood, Christopher J., Ivanova, Masha Y., Jonas, Katherine G., Latzman, Robert D., Markon, Kristian E., Miller, Joshua D., Morey, Leslie C., Mullins-Sweatt, Stephanie N., Ormel, Johan, Patalay, Praveetha, Patrick, Christopher J., Pincus, Aaron L., Regier, Darrel A., Reininghaus, Ulrich, Rescorla, Leslie A., Samuel, Douglas B., Sellbom, Martin, Shackman, Alexander J., Skodol, Andrew, Slade, Tim, South, Susan C., Sunderland, Matthew, Tackett, Jennifer L., Venables, Noah C., Waldman, Irwin D., Waszczuk, Monika A., Waugh, Mark H., Wright, Aidan G.C., Zald, David H., and Zimmermann, Johannes

Published
2021
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26. Parental Bipolar Disorder and Attachment Insecurity in Young Adults.

Author

Ruggero, Camilo J., Shelton, Andrew J., Bennett, Charles B., Dornbach-Bender, Allison, and Potts, Anabel

Subjects
*PARENTS, *BIPOLAR disorder, *SELF-evaluation, *ATTACHMENT behavior, *INTERVIEWING, *CHILDREN of parents with disabilities, *FAMILY relations, *PARENTING, *AFFECTIVE disorders, *ANXIETY, *RETROSPECTIVE studies, *RESEARCH methodology, *FATHERS, *MENTAL depression, *AVOIDANCE (Psychology), *TRANSITION to adulthood, *PSYCHOSOCIAL factors, *ADULTS
Abstract

Maternal depression predicts attachment insecurity in children, but parental bipolar disorder effects are less clear, particularly as children emerge into young adulthood. We assessed attachment in young adult children of parents with bipolar disorder (vs. depression and no mood disorder). Participants completed romantic attachment and retrospective parenting behavior self-reports, and semi-structured diagnostic interviews. Young adults with parental bipolar disorder endorsed more Avoidant and Anxious attachment, with father relationship quality partially mediating the effect. Results underscore the association of parental mood disorders with offspring attachment in emerging adulthood and highlight the importance of fathers in this dynamic. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Principles and procedures for revising the hierarchical taxonomy of psychopathology.

Author

Forbes, Miriam K., primary, Ringwald, Whitney R., additional, Allen, Timothy, additional, Cicero, David C., additional, Clark, Lee Anna, additional, DeYoung, Colin G., additional, Eaton, Nicholas, additional, Kotov, Roman, additional, Krueger, Robert F., additional, Latzman, Robert D., additional, Martin, Elizabeth A., additional, Naragon-Gainey, Kristin, additional, Ruggero, Camilo J., additional, Waldman, Irwin D., additional, Brandes, Cassandra, additional, Fried, Eiko I., additional, Goghari, Vina M., additional, Hankin, Benjamin, additional, Sperry, Sarah, additional, Stanton, Kasey, additional, Aftab, Awais, additional, Lynam, Donald, additional, Roche, Michael, additional, and Wright, Aidan G. C., additional

Published
2024
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45. Principles and procedures for revising the Hierarchical Taxonomy of Psychopathology

Author

Forbes, Miriam K., primary, Ringwald, Whitney R., additional, Allen, Timothy, additional, Cicero, David C, additional, Clark, Lee Anna, additional, DeYoung, Colin G., additional, Eaton, Nicholas R, additional, Naragon-Gainey, Kristin, additional, Kotov, Roman, additional, Krueger, Robert, additional, Latzman, Robert D, additional, Martin, Elizabeth A, additional, Ruggero, Camilo, additional, Waldman, Irwin, additional, Brandes, Cassandra M, additional, Fried, Eiko I, additional, Goghari, Vina, additional, Hankin, Benjamin, additional, Sperry, Sarah Havens, additional, Stanton, Kasey, additional, Aftab, Awais, additional, Lynam, Donald, additional, ROCHE, MICHAEL J, additional, and Wright, Aidan G.C., additional

Published
2023
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48. Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol

Author

Crowley, James J, Cappi, Carolina, Ochoa-Panaifo, Marcos E, Frederick, Renee M, Kook, Minjee, Wiese, Andrew D, Rancourt, Diana, Atkinson, Elizabeth G, Giusti-Rodriguez, Paola, Anderberg, Jacey L, Abramowitz, Jonathan S, Adorno, Victor R, Aguirre, Cinthia, Alves, Gustavo S, Alves, Gilberto S, Ancalade, NaEshia, Arellano Espinosa, Alejandro A, Arnold, Paul D, Ayton, Daphne M, Barbosa, Izabela G, Barón Castano, Laura Marcela, Barrera, Cynthia N, Belén Prieto, María, Berardo, María Celeste, Berrones, Dayan, Best, John R, Bigdeli, Tim B, Burton, Christie L, Callahan, Jennifer L, Carneiro, Maria Cecília B, Cepeda, Sandra L, Chazelle, Evelyn, Chire, Jessica M, Churruca Munoz, Macarena, Claisse Quiroz, Pamela, Cobite, Journa, Comer, Jonathan S, Costa, Daniel L, Crosbie, Jennifer, Cruz, Victor O, Dager, Guillermo, Daza, Luisa F, de la Rosa-Gómez, Anabel, del Río, Daniela, Delage, Fernanda Z, Dreher, Carolina B, Fay, Lucila, Fazio, Tomas, Ferrão, Ygor A, Ferreira, Gabriela M, Figueroa, Edith G, Fontenelle, Leonardo F, Forero, Diego A, Fragoso, Daniele TH, Gadad, Bharathi S, Garrison, Sheldon R, González, Andres, Gonzalez, Laura D, González, Marco A, Gonzalez-Barrios, Polaris, Goodman, Wayne, Guintivano, Jerry, Guttfreund, Daniel G, Guzick, Andrew G, Halvorsen, Matthew W, Hovey, Joseph D, Janssen-Aguilar, Reinhard, Jensen, Matias, Jimenez Reynolds, Alexandra Z, Juárez Lujambio, Joali Alexandra, Khalfe, Nasim, Knutsen, Madison A, Lack, Caleb, Lanzagorta, Nuria, Lima, Monicke O, Longhurst, Melanie O, Lozada Martinez, David A, Luna, Elba S, Marques, Andrea H, Martinez, Molly, Matos, Maria de Los Angeles, Maye, Caitlyn E, McGuire, Joseph F, Menezes, Gabriela, Minaya, Charlene, Miño, Tomás, Mithani, Sara M, Montes de Oca, Circe, Morales-Rivero, Alonso, Moreira-de-Oliveira, Maria E, Morris, Olivia J, Muñoz, Sandra I, Naqqash, Zainab, Núñez Bracho, Ambar A, Núñez Bracho, Belinda E, Ochoa Rojas, Maria Corina, Olavarria Castaman, Luis A, Ortega, Iliana, Patel, Darpan I, Patrick, Ainsley K, Paz y Mino, Mariel, Perales Orellana, Jose L, Perdigão Stumpf, Bárbara, Peregrina, Tamara, Pérez Duarte, Tania, Piacsek, Kelly L, Placencia, Maritza, Quarantini, Lucas C, Quarantini-Alvim, Yana, Ramos, Renato T, Ramos, Iaroslava C, Ramos, Vanessa R, Ramsey, Kesley A, Ray, Elise V, Richter, Margaret A, Riemann, Bradley C, Rivas, Juan C, Rosario, Maria C, Ruggero, Camilo J, Ruiz-Chow, Angel A, Ruiz-Velasco, Alejandra, Sampaio, Aline S, Saraiva, Leonardo C, Schachar, Russell J, Schneider, Sophie C, Schweissing, Ethan J, Seligman, Laura D, Shavitt, Roseli G, Soileau, Keaton J, Stewart, S. Evelyn, Storch, Shaina B, Strouphauer, Emily R, Timpano, Kiara R, Treviño-de la Garza, Beatriz, Vargas-Medrano, Javier, Vásquez, María I, Vidal Martinez, Guadalupe, Weinzimmer, Saira A, Yanez, Mauricio A, Zai, Gwyneth, Zapata-Restrepo, Lina M, Zappa, Luz M, Zepeda-Burgos, Raquel M, Zoghbi, Anthony W, Miguel, Euripedes C, Rodriguez, Carolyn I, Martinez Mallen, Mayra C, Moya, Pablo R, Borda, Tania, Moyano, María Beatriz, Mattheisen, Manuel, Pereira, Stacey, Lázaro-Muñoz, Gabriel, Martinez-Gonzalez, Karen G, Pato, Michele T, Nicolini, Humberto, and Storch, Eric A

Subjects
Article
Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org ). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

Published
2023

49. The Role of Personality in the Mental and Physical Health of World Trade Center Responders: Self-Reports Versus Informant-Reports

Author

Oltmanns, Joshua R., Ruggero, Camilo, Miao, Jiaju, Waszczuk, Monika, Yang, Yuanyuan, Clouston, Sean A. P., Bromet, Evelyn J., Luft, Benjamin J., and Kotov, Roman

Abstract

Personality is linked to important health outcomes, but most prior studies have relied on self-reports, making it possible that shared-method variance explains the associations. In the present study, we examined self-reports versus informant-reports of personality and multimethod outcomes. World Trade Center (WTC) responders and informants, 283 pairs, completed five-factor model personality measures and multimethod assessments of stressful events, functioning, mental disorders, 9/11-related treatment costs, body mass index (BMI), and daily activity across 3 years. Self-reports were uniquely related to stressful events and functioning. Both self-reports and informant-reports showed incremental validity over one another for mental disorder diagnoses and treatment costs. For objective outcomes daily activity and BMI, informant-reports showed incremental validity over self-reports, accounting for all self-report variance and more. The findings suggest that informant-reports of personality provide better validity for objective health outcomes, which has implications for understanding personality and its role in mental and physical health.

Published
2023
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