1. Models for assessing antipsychotics: antagonism of amphetamine-induced hyperactivity and stereotypies in mice
- Author
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Anne-Marie Hay, Sylvain Roux, and Ruger D. Porsolt
- Subjects
Male ,medicine.medical_specialty ,Acute proliferative glomerulonephritis ,Renal function ,Stereotypic Movement Disorder ,Pharmacology ,Hyperkinesis ,Mice ,Dopamine ,Internal medicine ,Haloperidol ,Medicine ,Animals ,Chlorpromazine ,Amphetamine ,business.industry ,Glomerulonephritis ,Effective renal plasma flow ,medicine.disease ,Disease Models, Animal ,Endocrinology ,business ,medicine.drug ,Antipsychotic Agents - Abstract
All classical antipsychotics, such as chlorpromazine and haloperidol, have potent dopamine receptor-blocking properties. This unit describes the rat anti-Thy-1.1 model of acute proliferative glomerulonephritis for the study of chronic renal insufficiency. A procedure is detailed for the induction of glomerulonephritis in rats as well as measurement of daily urinary excretion of protein, which is a convenient, primary screening tool. The unit also provides methods for assessment of glomerular filtration rate and effective renal plasma flow in anesthetized rats with anti-Thy-1.1-induced renal insufficiency.
- Published
- 2011