129 results on '"Ruffo, M"'
Search Results
2. Liraglutide improves cardiac function in patients with type 2 diabetes and chronic heart failure
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Arturi, F., Succurro, E., Miceli, S., Cloro, C., Ruffo, M., Maio, R., Perticone, M., Sesti, G., and Perticone, F.
- Published
- 2017
- Full Text
- View/download PDF
3. Floatingline Estimation in FHR Signal Analysis
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Cesarelli, M., Romano, M., D’Addio, G., Ruffo, M., Bifulco, P., Pasquariello, G., Fratini, A., Magjarevic, Ratko, editor, and Jobbágy, Ákos, editor
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- 2012
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4. A Simulation of the Surface EMG for Analysis of Muscle Activity during Whole Body Vibratory Stimulation
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Fratini, A., Cesarelli, M., Bifulco, P., Romano, M., Ruffo, M., Magjarevic, Ratko, Dössel, Olaf, editor, and Schlegel, Wolfgang C., editor
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- 2010
- Full Text
- View/download PDF
5. Comparison of software developed for FHR extraction from PCG signals
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Ruffo, M., Romano, M., Cesarelli, M., Bifulco, P., Fratini, A., Pasquariello, G., Iaccarino, M., Iaccarino, S., Magjarevic, Ratko, Dössel, Olaf, editor, and Schlegel, Wolfgang C., editor
- Published
- 2010
- Full Text
- View/download PDF
6. An algorithm for FHR extraction from FHS signals
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Cesarelli, Mario, Ruffo, M., Romano, M., Bifulco, P., Kovacs, F., Iaccarino, S., Magjarevic, R., editor, Nagel, J. H., editor, Vander Sloten, Jos, editor, Verdonck, Pascal, editor, Nyssen, Marc, editor, and Haueisen, Jens, editor
- Published
- 2009
- Full Text
- View/download PDF
7. Simulation of foetal phonocardiographic recordings for testing of FHR extraction algorithms
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Cesarelli, M., Ruffo, M., Romano, M., and Bifulco, P.
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- 2012
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8. Investigating the role of combined acoustic-visual feedback in one-dimensional synchronous brain computer interfaces, a preliminary study
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Gargiulo GD, Mohamed A, McEwan AL, Bifulco P, Cesarelli M, Jin CT, Ruffo M, Tapson J, and van Schaik A
- Subjects
Medical technology ,R855-855.5 - Abstract
Gaetano D Gargiulo,1–3 Armin Mohamed,1 Alistair L McEwan,1 Paolo Bifulco,2 Mario Cesarelli,2 Craig T Jin,1 Mariano Ruffo,2 Jonathan Tapson,3 André van Schaik31School of Electrical and Information Engineering, The University of Sydney, New South Wales, Australia; 2Dipartimento di Ingegneria Elettronica e delle Telecomunicazioni "Federico II" University of Naples, Naples, Italy; 3BENS Laboratory, MARCS Institute, The University of Western Sydney, New South Wales, AustraliaAbstract: Feedback plays an important role when learning to use a brain computer interface (BCI), particularly in the case of synchronous feedback that relies on the interaction subject. In this preliminary study, we investigate the role of combined auditory-visual feedback during synchronous µ rhythm-based BCI sessions to help the subject to remain focused on the selected imaginary task. This new combined feedback, now integrated within the general purpose BCI2000 software, has been tested on eight untrained and three trained subjects during a monodimensional left-right control task. In order to reduce the setup burden and maximize subject comfort, an electroencephalographic device suitable for dry electrodes that required no skin preparation was used. Quality and index of improvement was evaluated based on a personal self-assessment questionnaire from each subject and quantitative data based on subject performance. Results for this preliminary study show that the combined feedback was well tolerated by the subjects and improved performance in 75% of the naïve subjects compared with visual feedback alone.Keywords: brain computer interface, dry electrodes, subject feedback
- Published
- 2012
9. PSD modifications of FHRV due to interpolation and CTG storage rate
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Cesarelli, M., Romano, M., Ruffo, M., Bifulco, P., Pasquariello, G., and Fratini, A.
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- 2011
- Full Text
- View/download PDF
10. An algorithm for FHR estimation from foetal phonocardiographic signals
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Ruffo, M., Cesarelli, M., Romano, M., Bifulco, P., and Fratini, A.
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- 2010
- Full Text
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11. Cropping system and nitrogen dynamics under a cereal winter cover crop preceding corn
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Crandall, S. M., Ruffo, M. L., and Bollero, G. A.
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- 2005
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12. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in elderly patients
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Arturi F, Costante G, Cloro C, Ruffo M, Mastroianni S, Pedace E, Cufone S, Caruso V, Iorio F, Lugarà M, Succurro E, and Grembiale A
- Subjects
Geriatrics ,RC952-954.6 - Published
- 2010
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13. Plasma levels of fibrinogen and ambulatory blood pressure monitoring: study in elderly patients
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Arturi F, Cloro C, Ruffo M, Mastroianni S, Pedace E, Cufone S, Caruso V, Iorio F, Succurro E, Grembiale A, and Lugarà M
- Subjects
Geriatrics ,RC952-954.6 - Published
- 2010
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14. Floatingline Estimation in FHR Signal Analysis
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Cesarelli, M., primary, Romano, M., additional, D’Addio, G., additional, Ruffo, M., additional, Bifulco, P., additional, Pasquariello, G., additional, and Fratini, A., additional
- Published
- 2011
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- View/download PDF
15. Comparison of software developed for FHR extraction from PCG signals
- Author
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Ruffo, M., primary, Romano, M., additional, Cesarelli, M., additional, Bifulco, P., additional, Fratini, A., additional, Pasquariello, G., additional, Iaccarino, M., additional, and Iaccarino, S., additional
- Published
- 2009
- Full Text
- View/download PDF
16. A Simulation of the Surface EMG for Analysis of Muscle Activity during Whole Body Vibratory Stimulation
- Author
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Fratini, A., primary, Cesarelli, M., additional, Bifulco, P., additional, Romano, M., additional, and Ruffo, M., additional
- Published
- 2009
- Full Text
- View/download PDF
17. Evaluación de la estabilidad de taludes rocosos a partir de nubes de puntos 3D obtenidas con un vehículo aéreo no tripulado
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Tomás, R., primary, Riquelme, A., additional, Cano, M., additional, Pastor, J. L., additional, Pagán, J. I., additional, Asensio, J. L., additional, and Ruffo, M., additional
- Published
- 2020
- Full Text
- View/download PDF
18. Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study
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Vitale, M, Masulli, M, Rivellese, A, Bonora, E, Cappellini, F, Nicolucci, A, Squatrito, S, Antenucci, D, Barrea, A, Bianchi, C, Bianchini, F, Fontana, L, Fornengo, P, Giorgino, F, Gnasso, A, Mannucci, E, Mazzotti, A, Nappo, R, Palena, A, Pata, P, Perriello, G, Potenziani, S, Radin, R, Ricci, L, Romeo, F, Santini, C, Scarponi, M, Serra, R, Timi, A, Turco, A, Vedovato, M, Zavaroni, D, Grioni, S, Riccardi, G, Vaccaro, O, Cocozza, S, Auciello, S, Cigolini, M, Pichiri, I, Brangani, C, Tomasetto, E, Sinagra, T, Longhitano, S, Tropea, V, Ballardini, G, Babini, A, Ripani, R, Gregori, G, Dolci, M, Bruselli, L, Salutini, I, Mori, M, Baccetti, F, Lapolla, A, Sartore, G, Burlina, S, Chilelli, N, Buzzetti, R, Venditti, C, Carlone, A, Galluzzo, A, Giordano, C, Torregrossa, V, Corsi, L, Cuneo, G, Corsi, S, Tizio, B, Galluzzo, G, Citro, G, Natale, M, Salvatore, V, Di Cianni, G, Lacaria, E, Russo, L, Iannarelli, R, De Gregorio, A, Sciarretta, F, D'Andrea, S, Montani, V, Cannarsa, E, Dolcetti, K, Cordera, R, Bonabello, L, Mazzucchelli, C, Giorda, C, Bonetto, C, Baldassarre, M, Iovine, C, Ciano, O, Dall'Aglio, E, Mancastroppa, G, Grimaldi, F, Tonutti, L, Boemi, M, D'Angelo, F, Leotta, S, Lauro, D, Rinaldi, M, Cignarelli, M, La Macchia, O, Fariello, S, Tomasi, F, Zamboni, C, Dozio, N, Trevisan, R, Scaranna, C, Del Prato, S, Miccoli, R, Garofolo, M, Pugliese, G, Salvi, L, Rangel, G, Anichini, R, Tedeschi, A, Corsini, E, Cucinotta, D, Di Benedetto, A, Giunta, L, Ruffo, M, Bossi, A, Carpinter, R, Dotta, F, Ceccarelli, E, Bartolo, P, Caselli, C, Luberto, A, Calbucci, G, Consoli, A, Ginestra, F, Calabrese, M, Zogheri, A, Laviola, L, Ippolito, C, Tarantino, L, Avogaro, A, Carallo, C, Scicchitano, C, Livraga, S, Perin, P, Forrnengo, P, Prinzis, T, De Cosmo, S, Bacci, S, Lamanna, C, Lettina, G, Aiello, A, Lalli, C, Franzetti, I, Petrachi, F, Asprino, V, Capra, C, Forte, E, Reggiani, G, Forlani, G, Montesi, L, Mazzella, N, Piatti, P, Monti, L, Stuccillo, M, Auletta, P, Petraroli, E, Capobianco, G, Romano, G, Cutolo, M, De Simone, G, Caiazzo, G, Nunziata, P, Sorrentino, S, Amelia, U, Calatola, P, Capuano, G, Vitale M., Masulli M., Rivellese A. A., Bonora E., Cappellini F., Nicolucci A., Squatrito S., Antenucci D., Barrea A., Bianchi C., Bianchini F., Fontana L., Fornengo P., Giorgino F., Gnasso A., Mannucci E., Mazzotti A., Nappo R., Palena A. P., Pata P., Perriello G., Potenziani S., Radin R., Ricci L., Romeo F., Santini C., Scarponi M., Serra R., Timi A., Turco A. A., Vedovato M., Zavaroni D., Grioni S., Riccardi G., Vaccaro O., Cocozza S., Auciello S., Cigolini M., Pichiri I., Brangani C., Tomasetto E., Sinagra T., Longhitano S., Tropea V., Ballardini G., Babini A. C., Ripani R., Gregori G., Dolci M., Bruselli L., Salutini I., Mori M., Baccetti F., Lapolla A., Sartore G., Burlina S., Chilelli N. C., Buzzetti R., Venditti C., Carlone A., Galluzzo A., Giordano C., Torregrossa V., Corsi L., Cuneo G., Corsi S., Tizio B., Galluzzo G., Citro G., Natale M., Salvatore V., Di Cianni G., Lacaria E., Russo L., Iannarelli R., De Gregorio A., Sciarretta F., D'Andrea S., Montani V., Cannarsa E., Dolcetti K., Cordera R., Bonabello L. A., Mazzucchelli C., Giorda C. B., Bonetto C., Baldassarre M. P. A., Iovine C., Ciano O., Dall'Aglio E., Mancastroppa G., Grimaldi F., Tonutti L., Boemi M., D'Angelo F., Leotta S., Lauro D., Rinaldi M. E., Cignarelli M., La Macchia O., Fariello S., Tomasi F., Zamboni C., Dozio N., Trevisan R., Scaranna C., Del Prato S., Miccoli R., Garofolo M., Pugliese G., Salvi L., Rangel G., Anichini R., Tedeschi A., Corsini E., Cucinotta D., Di Benedetto A., Giunta L., Ruffo M. C., Bossi A. C., Carpinter R., Dotta F., Ceccarelli E., Bartolo P. D., Caselli C., Luberto A., Calbucci G., Consoli A., Ginestra F., Calabrese M., Zogheri A., Laviola L., Ippolito C., Tarantino L., Avogaro A., Carallo C., Scicchitano C., Livraga S., Perin P. C., Forrnengo P., Prinzis T., De Cosmo S., Bacci S., Lamanna C., Lettina G., Aiello A., Lalli C., Franzetti I., Petrachi F., Asprino V., Capra C., Forte E., Reggiani G. M., Forlani G., Montesi L., Mazzella N., Piatti P. M., Monti L., Stuccillo M., Auletta P., Petraroli E., Capobianco G., Romano G., Cutolo M., De Simone G., Caiazzo G., Nunziata P., Sorrentino S., Amelia U., Calatola P., Capuano G., Vitale, M, Masulli, M, Rivellese, A, Bonora, E, Cappellini, F, Nicolucci, A, Squatrito, S, Antenucci, D, Barrea, A, Bianchi, C, Bianchini, F, Fontana, L, Fornengo, P, Giorgino, F, Gnasso, A, Mannucci, E, Mazzotti, A, Nappo, R, Palena, A, Pata, P, Perriello, G, Potenziani, S, Radin, R, Ricci, L, Romeo, F, Santini, C, Scarponi, M, Serra, R, Timi, A, Turco, A, Vedovato, M, Zavaroni, D, Grioni, S, Riccardi, G, Vaccaro, O, Cocozza, S, Auciello, S, Cigolini, M, Pichiri, I, Brangani, C, Tomasetto, E, Sinagra, T, Longhitano, S, Tropea, V, Ballardini, G, Babini, A, Ripani, R, Gregori, G, Dolci, M, Bruselli, L, Salutini, I, Mori, M, Baccetti, F, Lapolla, A, Sartore, G, Burlina, S, Chilelli, N, Buzzetti, R, Venditti, C, Carlone, A, Galluzzo, A, Giordano, C, Torregrossa, V, Corsi, L, Cuneo, G, Corsi, S, Tizio, B, Galluzzo, G, Citro, G, Natale, M, Salvatore, V, Di Cianni, G, Lacaria, E, Russo, L, Iannarelli, R, De Gregorio, A, Sciarretta, F, D'Andrea, S, Montani, V, Cannarsa, E, Dolcetti, K, Cordera, R, Bonabello, L, Mazzucchelli, C, Giorda, C, Bonetto, C, Baldassarre, M, Iovine, C, Ciano, O, Dall'Aglio, E, Mancastroppa, G, Grimaldi, F, Tonutti, L, Boemi, M, D'Angelo, F, Leotta, S, Lauro, D, Rinaldi, M, Cignarelli, M, La Macchia, O, Fariello, S, Tomasi, F, Zamboni, C, Dozio, N, Trevisan, R, Scaranna, C, Del Prato, S, Miccoli, R, Garofolo, M, Pugliese, G, Salvi, L, Rangel, G, Anichini, R, Tedeschi, A, Corsini, E, Cucinotta, D, Di Benedetto, A, Giunta, L, Ruffo, M, Bossi, A, Carpinter, R, Dotta, F, Ceccarelli, E, Bartolo, P, Caselli, C, Luberto, A, Calbucci, G, Consoli, A, Ginestra, F, Calabrese, M, Zogheri, A, Laviola, L, Ippolito, C, Tarantino, L, Avogaro, A, Carallo, C, Scicchitano, C, Livraga, S, Perin, P, Forrnengo, P, Prinzis, T, De Cosmo, S, Bacci, S, Lamanna, C, Lettina, G, Aiello, A, Lalli, C, Franzetti, I, Petrachi, F, Asprino, V, Capra, C, Forte, E, Reggiani, G, Forlani, G, Montesi, L, Mazzella, N, Piatti, P, Monti, L, Stuccillo, M, Auletta, P, Petraroli, E, Capobianco, G, Romano, G, Cutolo, M, De Simone, G, Caiazzo, G, Nunziata, P, Sorrentino, S, Amelia, U, Calatola, P, Capuano, G, Vitale M., Masulli M., Rivellese A. A., Bonora E., Cappellini F., Nicolucci A., Squatrito S., Antenucci D., Barrea A., Bianchi C., Bianchini F., Fontana L., Fornengo P., Giorgino F., Gnasso A., Mannucci E., Mazzotti A., Nappo R., Palena A. P., Pata P., Perriello G., Potenziani S., Radin R., Ricci L., Romeo F., Santini C., Scarponi M., Serra R., Timi A., Turco A. A., Vedovato M., Zavaroni D., Grioni S., Riccardi G., Vaccaro O., Cocozza S., Auciello S., Cigolini M., Pichiri I., Brangani C., Tomasetto E., Sinagra T., Longhitano S., Tropea V., Ballardini G., Babini A. C., Ripani R., Gregori G., Dolci M., Bruselli L., Salutini I., Mori M., Baccetti F., Lapolla A., Sartore G., Burlina S., Chilelli N. C., Buzzetti R., Venditti C., Carlone A., Galluzzo A., Giordano C., Torregrossa V., Corsi L., Cuneo G., Corsi S., Tizio B., Galluzzo G., Citro G., Natale M., Salvatore V., Di Cianni G., Lacaria E., Russo L., Iannarelli R., De Gregorio A., Sciarretta F., D'Andrea S., Montani V., Cannarsa E., Dolcetti K., Cordera R., Bonabello L. A., Mazzucchelli C., Giorda C. B., Bonetto C., Baldassarre M. P. A., Iovine C., Ciano O., Dall'Aglio E., Mancastroppa G., Grimaldi F., Tonutti L., Boemi M., D'Angelo F., Leotta S., Lauro D., Rinaldi M. E., Cignarelli M., La Macchia O., Fariello S., Tomasi F., Zamboni C., Dozio N., Trevisan R., Scaranna C., Del Prato S., Miccoli R., Garofolo M., Pugliese G., Salvi L., Rangel G., Anichini R., Tedeschi A., Corsini E., Cucinotta D., Di Benedetto A., Giunta L., Ruffo M. C., Bossi A. C., Carpinter R., Dotta F., Ceccarelli E., Bartolo P. D., Caselli C., Luberto A., Calbucci G., Consoli A., Ginestra F., Calabrese M., Zogheri A., Laviola L., Ippolito C., Tarantino L., Avogaro A., Carallo C., Scicchitano C., Livraga S., Perin P. C., Forrnengo P., Prinzis T., De Cosmo S., Bacci S., Lamanna C., Lettina G., Aiello A., Lalli C., Franzetti I., Petrachi F., Asprino V., Capra C., Forte E., Reggiani G. M., Forlani G., Montesi L., Mazzella N., Piatti P. M., Monti L., Stuccillo M., Auletta P., Petraroli E., Capobianco G., Romano G., Cutolo M., De Simone G., Caiazzo G., Nunziata P., Sorrentino S., Amelia U., Calatola P., and Capuano G.
- Abstract
Purpose: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. Methods: We studied 2573 men and women aged 50–75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Phenol-Explorer databases. Results: The mean total polyphenol intake was 683.3 ± 5.8 mg/day. Non-alcoholic beverages represented the main food source of dietary polyphenols and provided 35.5% of total polyphenol intake, followed by fruits (23.0%), alcoholic beverages (14.0%), vegetables (12.4%), cereal products and tubers (4.6%), legumes (3.7%) and oils (2.1%); chocolate, cakes and nuts are negligible sources of polyphenols in this cohort. The two most important polyphenol classes contributing to the total intake were flavonoids (47.5%) and phenolic acids (47.4%). Polyphenol intake increased with age and education level and decreased with BMI; furthermore, in the northern regions of Italy, the polyphenol intake was slightly, but significantly higher than in the central or southern regions. Conclusions: The study documents for the first time the intake of polyphenols and their main food sources in people with diabetes using validated and complete databases of the polyphenol content of food. Compared with published data, collected in people without diabetes, these results suggest a lower intake and a different pattern of intake in people with diabetes.
- Published
- 2018
19. ANTI- PSEUDOMONAS AERUGINOSA IGA AND IGG ANTIBODIES IN THE SERUM OF CYSTIC FIBROSIS PATIENTS PRIOR TO BACTERIA ISOLATION: 328
- Author
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Taccetti, G., Ruffo, M., Lori, I., Neri, A., Ravenni, N., Costantini, D., Russo, M., Festini, F., Campana, S., and Cariani, L.
- Published
- 2006
20. Evaluación de la estabilidad de taludes rocosos a partir de nubes de puntos 3D obtenidas con un vehículo aéreo no tripulado
- Author
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European Commission, Universidad de Alicante, Ministerio de Economía y Competitividad, European Regional Development Fund, Tomás, R., Riquelme, A., Cano, M., Pastor, J. L., Pagán, J. I., Asensio, J. L., Ruffo, M., European Commission, Universidad de Alicante, Ministerio de Economía y Competitividad, European Regional Development Fund, Tomás, R., Riquelme, A., Cano, M., Pastor, J. L., Pagán, J. I., Asensio, J. L., and Ruffo, M.
- Abstract
[ES] En este trabajo se describe una metodología propuesta para la identificación semiautomática de discontinuidades y el posterior análisis cinemático y de estabilidad a través de su aplicación a una trinchera excavada en roca de una línea de ferrocarril. La adquisición de imágenes se ha llevado a cabo mediante un vehículo aéreo no tripulado de seis rotores para su posterior restitución fotogramétrica a través de la técnica digital Structure from Motion (SfM) mediante el programa Agisoft Metashape que proporciona una nube de puntos 3D. A partir de esta nube de puntos, se han identificado cuatro familias de discontinuidades (J1, J2, J3 y J4) que afectan al talud haciendo uso del programa de código abierto Discontinuity Set Extractor (DSE). Finalmente, se han llevado a cabo análisis cinemáticos y de estabilidad de las posibles roturas de bloques a favor de las discontinuidades identificadas en el talud. Los resultados muestran tres potenciales roturas por cuña y una plana que han sido validadas cualitativamente mediante el análisis de la geometría de las nubes de puntos., [EN] In this work, a methodology proposed for the semiautomatic identification of discontinuities and the later kinematic and stability analyses is described through its application to a rocky railway line cutting. Image acquisition has been performed using a six-rotors unmanned aerial vehicle for their subsequent photogrammetric restitution by means of the digital technique Structure from Motion (SfM) by means of the software Agisoft Metashape that provides a 3D point cloud. From this 3D point cloud, four discontinuity sets (J1, J2, J3 and J4) affecting the cutting have been identified using the open source software Discontinuity Set Extractor (DSE). Finally, kinematic and stability analyses of the potential block failures controlled by the discontinuities identified in the cutting. The results show three potential wedge and planar failures that have been qualitatively validated trough the geometric analysis of the 3D point cloud.
- Published
- 2020
21. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
- Author
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Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., Agrusta M., Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., and Agrusta M.
- Abstract
Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50–75 years with type 2 diabetes inadequately controlled with metformin monotherapy (2–3 g per day) were recruited from 57 diabetes clinics in Italy. Patients were randomly assigned (1:1), by permuted blocks randomisation (block size 10), stratified by site and previous cardiovascular events, to add-on pioglitazone (15–45 mg) or a sulfonylurea (5–15 mg glibenclamide, 2–6 mg glimepiride, or 30–120 mg gliclazide, in accordance with local practice). The trial was unblinded, but event adjudicators were unaware of treatment assignment. The primary outcome, assessed with a Cox proportional-hazards model, was a composite of first occurrence of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularisation, assessed in the modified intention-to-treat population (all randomly assigned participants with baseline data available and without any protocol violations in relation to inclusion or exclusion criteria). This study is registered with ClinicalTrials.gov, number NCT00700856. Findings Between Sept 18, 2008, and Jan 15, 2014, 3028 patients were randomly assigned and included in the analyses. 1535 were assigned to pioglitazone and 1493 to sulfonylureas (glibenclamide 24 [2%], glimepiride 723 [48%], gliclazide 745 [50%]). At baseline, 335 (11%) participants had a previous cardiovascular event. The study was stopped early on the basis of a futility analysis after a median follow-up of 57·3 months. The primary outcome occurred in 105 patients (1·5 per 100 person-years) who were given pioglitazone and 108 (1·5 p
- Published
- 2017
22. Giga-ohm high-impedance fet input amplifiers for dry electrode biosensor circuits and systems
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Gargiulo G., Bifulco P., Calvo R. A., Romano M., Ruffo M., Shephard R., Cesarelli M., Jin C. c, McEwan A., Van Schaik A., Iniewski, Krzysztof, Gargiulo, G., Bifulco, P., Calvo, R. A., Romano, M., Ruffo, M., Shephard, R., Cesarelli, M., Jin, C. c., Mcewan, A., and Van Schaik, A.
- Abstract
Recently with rising health costs and an aging population, there is an increased demand for comfortable monitoring and sensing of biosignals in order to enable and encourage the transition of healthcare services into everyday living including the home, workplace, and during exercise. Sensors can be situated in objects that people interact with daily, such as within a computer, chair, bed, toilet, car, telephone, or any portable personal electronic device.
- Published
- 2017
23. Empirical laser sintering time estimator for Duraform PA.
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Ruffo, M., Tuck, C., and Hague, R.
- Subjects
MANUFACTURED products ,POWDER metallurgy ,COMPUTER-aided engineering ,MANUFACTURING processes ,EMPIRICAL research ,COST accounting ,GEOMETRY ,TECHNOLOGICAL innovations ,COMPUTERS ,AUTOMATION ,INDUSTRIAL engineering ,LASERS - Abstract
The paper presents work on the development of a build-time estimator for rapid manufacturing. A time estimator is required to develop a comprehensive costing tool for rapid manufacturing. An empirical method was used to estimate build times using both simulated and actual builds for a laser sintering machine. The estimator presented herein is based upon object geometry and, therefore, the fundamental data driving the model are obtainable from current three-dimensional computer-aided design models. The aim is to define a model describing the build times for a laser sintering machine either for single or multiple objects. [ABSTRACT FROM AUTHOR]
- Published
- 2006
- Full Text
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24. Sex differences in food choices, adherence to dietary recommendations and plasma lipid profile in type 2 diabetes
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Vitale, M., Masulli, M., Cocozza, S., Anichini, R., Babini, A., Boemi, M., Bonora, E., Buzzetti, R., Carpinteri, R., Caselli, C., Ceccarelli, E., Cignarelli, M., Citro, G., Clemente, G., Consoli A, C., De Gregorio, A., Di Bartolo, P., Di Cianni, G., Fontana, L., Garofolo, M., Giorda, C., Giordano, C., Grioni, S., Iovine, C., Longhitano, S., Mancastroppa, G., Mazzucchelli, C., Montani, V., Mori, M., Perriello, G., Rinaldi, M., Ruffo, M., Salvi, L., Sartore, G., Scaranna, C., Tonutti, L., Zamboni, C., Zogheri, A., Krogh, V., Cappellini, F., Signorini, S., Riccardi, G., Vaccaro, O., IT Study Group, T., Vitale M1, Masulli M, Cocozza S, Anichini R, Babini AC, Boemi M, Bonora E, Buzzetti R, Carpinteri R, Caselli C, Ceccarelli E, Cignarelli M, Citro G, Clemente G, Consoli A, Corsi L, De Gregorio A, Di Bartolo P, Di Cianni G, Fontana L, Garofolo M, Giorda CB, Giordano C, Grioni S, Iovine C, Longhitano S, Mancastroppa G, Mazzucchelli C, Montani V, Mori M, Perriello G, Rinaldi ME, Ruffo MC, Salvi L, Sartore G, Scaranna C, Tonutti L, Zamboni C, Zogheri A, Krogh V, Cappellini F, Signorini S, Riccardi G, Vaccaro O, and TOSCA.IT Study Group.
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tosca,Diabetes,Dietary habits,Nutritional recommendations,Sex differences,Men,Women,Cardiovascular risk factors - Abstract
Background and aims Diabetic women have a more adverse plasma lipid profile than men. Sex differences in dietary habits may play a role, but are little investigated. The study evaluates the quality of diet, adherence to the nutritional recommendations of the Diabetes and Nutrition Study Group and their relation with plasma lipid in men and women with diabetes. Methods and results We studied 2573 people, aged 50–75, enrolled in the TOSCA.IT study (clinicaltrials.gov; NCT00700856). Plasma lipids were measured centrally. Diet was assessed with a semi-quantitative food frequency questionnaire. Women had a more adverse plasma lipid profile than men. Women consumed significantly more legumes, vegetables, fruits, eggs, milk, vegetable oils, and added sugar, whereas men consumed more starchy foods, soft drinks and alcoholic beverages. This stands for a higher proportion (%) of energy intake from saturated fat and added sugar (12.0 ± 2.4 vs 11.5 ± 2.5 and 3.4 ± 3.2 vs 2.3 ± 3.2, P < 0.04), and a higher intake of fiber (11.2 ± 2.8 vs 10.4 ± 2.6 g/1000 Kcal/day) in women. Adherence to the recommendations for saturated fat and fiber consumption was associated with significantly lower LDL-cholesterol regardless of sex. Adherence to the recommendations for added sugars was associated with significantly lower triglycerides and higher HDL-cholesterol in men and women. Conclusions Men and women with diabetes show significant differences in adherence to nutritional recommendations, but sex differences in plasma lipid profile are unlikely to be explained by nutritional factors. Adherence to the nutritional recommendations is associated with a better plasma lipid profile regardless of sex, thus reinforcing the importance of substituting saturated for unsaturated fat sources, increasing fiber and reducing added sugar intake.
- Published
- 2016
25. Non-Invasive foetal monitoring with combined ECG - PCG system
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Ruffo M., Jin C., Gargiulo G., McEwan A., Sullivan C., Shephard R. W., van Schaik A., CESARELLI, MARIO, BIFULCO, PAOLO, ROMANO, MARIA, Anthony N. Laskovski, Ruffo, M., Cesarelli, Mario, Jin, C., Gargiulo, G., Mcewan, A., Sullivan, C., Bifulco, Paolo, Romano, Maria, Shephard, R. W., and van Schaik, A.
- Abstract
Although modern ultrasound provides remarkable images and biophysical measures, the technology is expensive and the observations are only available over a short time. Longer term monitoring is achieved in a clinical setting using ultrasonic Doppler cardiotocography (CTG) but this has a number of limitations. Some pathologies and some anomalies of cardiac functioning are not detectable with CTG. Moreover, although frequent and/or long-term foetal heart rate (FHR) monitoring is recommended, mainly in high risk pregnancies, there is a lack of established evidence for safe ultrasound irradiation exposure to the foetus for extended periods (Ang et al., 2006). Finally, high quality ultrasound devices are too expensive and not approved for home care use. In fact, there is a remarkable mismatch between ability to examine a foetus in a clinical setting, and the almost complete absence of technology that permits longer term monitoring of a foetus at home. Therefore, in the last years, many efforts (Hany et al., 1989; Jimenez et al., 1999; Kovacs et al., 2000; Mittra et al., 2008; Moghavvemi et al., 2003; Nagal, 1986; Ruffo et al., 2010; Talbert et al., 1986; Varady et al., 2003) have been attempted by the scientific community to find a suitable alternative. The development of new electronic systems and sensors now offers the potential of effective monitoring of the foetus using foetal phonocardiography (FPCG) and foetal electrocardiography (FECG) with passive, fully non-invasive low cost digital recording systems that could be suitable for home monitoring. These advances provide the opportunity of extending the recordings of the current commonly used CTG from relative short to long term, and provide new previously unavailable measures of cardiac function. In this chapter, we present highlights of our research into non-invasive foetal monitoring. We introduce the use of FECG, FPCG and their combination in order to detect the foetal heart rate (FHR) and potential functional anomalies. We present signal processing methodologies, suitable for longer-term assessment, to detect heart beat events, such as first and second heart sounds and QRS waves, which provide reliable measures of heart rate, and offer the potential of new information about measurement of the systolic time intervals and foetus circulatory impedance.
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- 2011
26. Liraglutide improves cardiac function in patients with type 2 diabetes and chronic heart failure
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Arturi, F., primary, Succurro, E., additional, Miceli, S., additional, Cloro, C., additional, Ruffo, M., additional, Maio, R., additional, Perticone, M., additional, Sesti, G., additional, and Perticone, F., additional
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- 2016
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27. Nuove evidenze sul ruolo della supplementazione con inositolo nel diabete gestazionale
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Di Benedetto, Antonino, Giunta, L., Ruffo, M. C., and Cannizzaro, D.
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Diabetes and Metabolism ,Endocrinology ,Internal Medicine ,Gestational diabetes ,Inositol ,Insulin resistance ,Endocrinology, Diabetes and Metabolism - Published
- 2013
28. Glucagon-like peptide-1 analogues: effects on body weight and glycemia
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Ruffo, M, Hribal, Ml, and Sesti, G
- Published
- 2010
29. The Ceprano basin and its prehistoric evidenc
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Biddittu I., Palombo M.R., Magri D., Milli S., Barbieri Mr., Barbieri Mz., Celiberti V., Margari V., Melis R.T., Ruffo M., Saracino B., and Manzi G.
- Published
- 2009
30. The limestone industry of the paleolithic site of Isernia La Pineta (Molise, Italy): an interpretative model of the behavioral strategies
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Peretto, C., Minelli, A., and Ruffo, M.
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Socio-culturale - Published
- 2006
31. OP0222 Inactivation of Urokinase-Type Plasminogen Activator Receptor Induces Dermal and Pulmonary Fibrosis and Peripheral Microvasculopathy in Mice Closely Resembling Human Systemic Sclerosis
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Manetti, M., primary, Rosa, I., additional, Milia, A. F., additional, Ruffo, M., additional, Guiducci, S., additional, Ibba-Manneschi, L., additional, and Matucci-Cerinic, M., additional
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- 2013
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32. Neuromuscular response to whole body vibration treatment during static and dynamic squat exercises
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Cesarelli, M., primary, Di Iorio, F., additional, Bifulco, P., additional, Clemente, F., additional, Fratini, A., additional, and Ruffo, M., additional
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- 2012
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33. A wearable device for recording of biopotentials and body movements
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Bifulco, P., primary, Cesarelli, M., additional, Fratini, A., additional, Ruffo, M., additional, Pasquariello, G., additional, and Gargiulo, Gaetano, additional
- Published
- 2011
- Full Text
- View/download PDF
34. A simulating software of fetal phonocardiographic signals
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Ruffo, M., primary, Cesarelli, M., additional, Romano, M., additional, Bifulco, P., additional, and Fratini, A., additional
- Published
- 2010
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- View/download PDF
35. Dry electrode bio-potential recordings
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Gargiulo, G, primary, Bifulco, P, additional, McEwan, A, additional, Nasehi Tehrani, Joubin, additional, Calvo, Rafael A, additional, Romano, M, additional, Ruffo, M, additional, Shephard, R, additional, Cesarelli, M, additional, Jin, C, additional, Mohamed, A, additional, and van Schaik, André, additional
- Published
- 2010
- Full Text
- View/download PDF
36. B-type natriuretic peptide (NT-proBNP) and thyroid function: study in elderly subjects
- Author
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Mastroianni, S, primary, Grembiale, A, additional, Succurro, E, additional, Lugarà, M, additional, Iorio, F, additional, Caruso, V, additional, Cufone, S, additional, Pedace, E, additional, Ruffo, M, additional, Cloro, C, additional, and Arturi, F, additional
- Published
- 2010
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- View/download PDF
37. Plasma levels of fibrinogen and ambulatory blood pressure monitoring: study in elderly patients
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Lugarà, M, primary, Grembiale, A, additional, Succurro, E, additional, Iorio, F, additional, Caruso, V, additional, Cufone, S, additional, Pedace, E, additional, Mastroianni, S, additional, Ruffo, M, additional, Cloro, C, additional, and Arturi, F, additional
- Published
- 2010
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- View/download PDF
38. Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in elderly patients
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Grembiale, A, primary, Succurro, E, additional, Lugarà, M, additional, Iorio, F, additional, Caruso, V, additional, Cufone, S, additional, Pedace, E, additional, Mastroianni, S, additional, Ruffo, M, additional, Cloro, C, additional, Costante, G, additional, and Arturi, F, additional
- Published
- 2010
- Full Text
- View/download PDF
39. Relationship of source and sink in determining kernel composition of maize
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Seebauer, J. R., primary, Singletary, G. W., additional, Krumpelman, P. M., additional, Ruffo, M. L., additional, and Below, F. E., additional
- Published
- 2009
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40. PSD modifications of FHRV due to CTG storage rate
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Cesarelli, M., primary, Romano, M., additional, Ruffo, M., additional, Bifulco, P., additional, Pasquariello, G., additional, and Fratini, A., additional
- Published
- 2009
- Full Text
- View/download PDF
41. Home care phonocardiography: an Italian experience
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Romano, M., primary, Cesarelli, M., additional, Ruffo, M., additional, Bifulco, P., additional, Iaccarino, M., additional, and Iaccarino, S., additional
- Published
- 2009
- Full Text
- View/download PDF
42. Rapid manufacturing facilitated customization
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Tuck, C. J., primary, Hague, R. J. M., additional, Ruffo, M., additional, Ransley, M., additional, and Adams, P., additional
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- 2008
- Full Text
- View/download PDF
43. Cost estimation for rapid manufacturing ’ simultaneous production of mixed components using laser sintering
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Ruffo, M, primary and Hague, R, additional
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- 2007
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- View/download PDF
44. Onboard fuel processor for PEM fuel cell vehicles
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BOWERS, B, primary, ZHAO, J, additional, RUFFO, M, additional, KHAN, R, additional, DATTATRAYA, D, additional, DUSHMAN, N, additional, BEZIAT, J, additional, and BOUDJEMAA, F, additional
- Published
- 2007
- Full Text
- View/download PDF
45. Cost estimation for rapid manufacturing - laser sintering production for low to medium volumes
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Ruffo, M, primary, Tuck, C, additional, and Hague, R, additional
- Published
- 2006
- Full Text
- View/download PDF
46. A wearable device for recording of biopotentials and body movements.
- Author
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Bifulco, P., Cesarelli, M., Fratini, A., Ruffo, M., Pasquariello, G., and Gargiulo, G.
- Published
- 2011
- Full Text
- View/download PDF
47. A simulating software of fetal phonocardiographic signals.
- Author
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Ruffo, M., Cesarelli, M., Romano, M., Bifulco, P., and Fratini, A.
- Published
- 2010
- Full Text
- View/download PDF
48. The effect of whole body vibration on oxygen uptake and electromyographic signal of the rectus femoris muscle during static and dynamic squat
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Di Iorio, F., Cesarelli, M., Bifulco, P., Fratini, A., Eliana Roveda, Ruffo, M., Di Iorio, F, Cesarelli, Mario, Bifulco, Paolo, Fratini, Antonio, Roveda, E, and Ruffo, M.
- Subjects
Vibration treatment ,Heart rate ,Oxygen consumption - Abstract
Whole Body Vibrations consist of a vibration stimulus mechanically transferred to the body. The impact of vibration treatment on specific muscular activity, neuromuscular, and postural control has been widely studied. We investigated whole body vibration (WBV) effect on oxygen uptake and electromyographic signal of the rectus femoris muscle during static and dynamic squat. Fourteen healthy subjects performed a static and dynamic squat with and without vibration. During the vibration exercises, a significant increase was found in oxygen uptake (P=0.05), which increased by 44% during the static squat and 29.4% during the dynamic squat. Vibration increased heart rate by 11.1 ± 9.1 beats.min-1 during the static squat and 7.9 ± 8.3 beats.min-1 during the dynamic squat. No significant changes were observed in rate of perceived exertion between the exercises with and without vibration. The results indicate that the static squat with WBV produced higher neuromuscular and cardiorespiratory system activation for exercise duration ?60 sec. Otherwise, if the single bout duration was higher than 60 sec, the greater cardiorespiratory system activation was achieved during the dynamic squat with WBV while higher neuromuscular activation was still obtained with the static exercise
49. An ultra-high input impedance ECG amplifier for long-term monitoring of athletes
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Gargiulo, G., Bifulco, P., Mario Cesarelli, Ruffo, M., Romano, M., Calvo, R. A., Jin, C., and Schaik, A.
50. Ceprano, Italy: excavations in the Lower Palaeolithic horizons at Campogrande and surroundings. Field seasons 2001-2005
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Giorgio Manzi, Biddittu, I., Celiberti, V., Follieri, M., Kent, D., Donatella Magri, Melis, R., Salvatore Milli, Muttoni, G., Maria Rita Palombo, Parenti, F., Ruffo, M., Saracino, B., Scardia, G., Segre Naldini, E., Swisher, C. C., and Segre, A. G.
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