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1. Multilevel non-contiguous thoracic pedicle subtraction osteotomy for fixed rounded hyperkyphotic deformity of the thoraco-lumbar junction with anterior bony fusion: technical note

Author

Faldini Cesare, Barile Francesca, Viroli Giovanni, Manzetti Marco, Geraci Giuseppe, and Ruffilli Alberto

Subjects
Kyphosis, Thoracolumbar junction, Pedicle substraction osteotomy, Sagittal imbalance, Orthopedic surgery, RD701-811
Abstract

Abstract Background Fixed severe hyperkyphotic deformities spread over more than five vertebral levels represent a therapeutic challenge, especially when the deformity apex is located at the thoraco-lumbar junction, thus requiring a huge amount of correction. The aim of this article is to describe an innovative all-posterior corrective technique based on multilevel non-contiguous thoracic pedicle subtraction ostoeotomy (PSO). Materials and methods A retrospective review of three patients with fixed severe thoracic hyperkyphosis (a deformity angle of over 70°) with a thoraco-lumbar apex (between T11 and L1) treated by simultaneous two-level thoracic PSO and thoraco-lumbar posterior fusion was performed. Radiographic and clinical records were evaluated pre-operatively, post-operatively and at last follow-up (after a minimum of 2 years). Each variable was presented as mean ± SD (standard deviation). Statistical analyses were performed using paired t-tests (P value

Published
2022
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2. Simultaneous Selective Thoracic Fusion of Lenke-1C Scoliosis and Reduction of Symptomatic Spondylolisthesis: A Case Report

Author

Ruffilli Alberto, Fiore Michele, Barile Francesca, Pasini Stefano, Viroli Giovanni, Manzetti Marco, and Faldini Cesare

Subjects
lenke-1c scoliosis, spondylolisthesis, spine deformity, selective thoracic vertebral arthrodesis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Diseases of the musculoskeletal system, RC925-935
Abstract

The combined treatment of unrelated Lenke-1C curves and spondylolisthesis represents a challenge: The two arthrodesis areas must achieve corrections while preserving mobility as much as possible. We reported a case of 20-year-old girl with Lenke-1C scoliosis and Meyerding grade-2 symptomatic L5-S1 isthmic spondylolisthesis. She was treated with one-stage correction with T3-T12 posterior selective thoracic fusion (STF) associated to reduction and fusion of the spondylolisthesis. Pre-op Cobb angle of the main thoracic (MT) curve was 62°. The non-structural lumbar (L) curve was 52°. Coronal imbalance was 39 mm. 1-month post-op X-ray showed a reduction of MT-curve to 32° and L-curve to 24°. The coronal imbalance was 13 mm. A satisfactory sagittal alignment and olisthesis reduction were achieved. At 24-months follow-up, L-curve increased to 30°. Coronal imbalance was 24 mm. Loss of correction appeared stable at 36-months final follow-up. Although the evidence cautiously suggests STF to treat also Lenke-1C scoliosis, this case confirmed that the risk of worsening coronal decompensation exists, and it is possibly increased by a distal lumbar arthrodesis to treat spondylolisthesis. However, we believe that STF is justified as worsening L-curve does not balance the possibility of preserving motility of the lumbar tract, also because the need for revision is an uncommon event.

Published
2021
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3. Superhydrophobic/superoleophilic magnetic elastomers by laser ablation

Author

Milionis, Athanasios, Fragouli, Despina, Brandi, Fernando, Liakos, Ioannis, Barroso, Suset, Ruffilli, Roberta, and Athanassiou, Athanassia

Subjects
Physics - Applied Physics, Condensed Matter - Soft Condensed Matter
Abstract

We report the development of magnetic nanocomposite sheets with superhydrophobic and superoleophilic surfaces generated by laser ablation. Polydimethylsiloxane elastomer freestanding films, loaded homogeneously with 2% wt. carbon coated iron nanoparticles, were ablated by UV (248 nm), nanosecond laser pulses. The laser irradiation induces chemical and structural changes (both in micro-and nano-scale) to the surfaces of the nanocomposites rendering them superhydrophobic. The use of nanoparticles increases the UV light absorption eficiency of the nanocomposite samples, and thus facilitates the ablation process, since the number of pulses and the laser fluence required are greatly reduced compared to the bare polymer. Additionally the magnetic nanoparticles enhance significantly the super-hydrophobic and oleophilic properties of the PDMS sheets, and provide to PDMS magnetic properties making possible its actuation by a weak external magnetic field. These nanocomposite elastomers can be considered for applications requiring magnetic MEMS for the controlled separation of liquids.

Published
2024
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17. Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features

Author

F. Salamanna, D. Contartese, G. Tedesco, A. Ruffilli, M. Manzetti, G. Viroli, M. Traversari, C. Faldini, and G. Giavaresi

Subjects
autologous cell therapies, graft substitutes, meta‐analysis, spinal fusion, Orthopedic surgery, RD701-811
Abstract

Abstract Over the past several decades, there has been a notable increase in the total number of spinal fusion procedures worldwide. Advanced spinal fusion techniques, surgical approaches, and new alternatives in grafting materials and implants, as well as autologous cellular therapies, have been widely employed for treating spinal diseases. While the potential of cellular therapies to yield better clinical results is appealing, supportive data are needed to confirm this claim. This meta‐analysis aims to compare the radiographic and clinical outcomes between graft substitutes with autologous cell therapies and graft substitutes alone. PubMed, Scopus, Web of Science, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials were searched for studies comparing graft substitutes with autologous cell therapies and graft substitutes alone up to February 2024. The risk of bias of the included studies was evaluated using the Downs and Black checklist. The following outcomes were extracted for comparison: fusion success, complications/adverse events, Visual Analog Scale (VAS) score, and Oswestry Disability Index (ODI) score. Thirteen studies involving 836 patients were included, with 7 studies considered for the meta‐analysis. Results indicated that the use of graft substitutes with autologous cell therapies demonstrated higher fusion success rates at 3, 6, and 12 months, lower VAS score at 6 months, and lower ODI score at 3, 6, and 12 months. The complication rate was similar between graft substitutes with autologous cell therapies and graft substitutes alone. Although the current literature remains limited, this meta‐analysis suggests that the incorporation of cellular therapies such as bone marrow and platelet derivatives with graft substitutes is associated with a higher fusion rate and significant improvements in functional status and pain following spinal fusion. Future well‐designed randomized clinical trials are needed to definitively assess the clinical effectiveness of cellular therapies in spinal fusion.

Published
2024
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18. Unfolding dermatologic spectrum of Behçet’s disease in Italy: real-life data from the International AIDA Network Behçet’s disease Registry

Author

D’Onghia, Martina, Cinotti, Elisa, Cartocci, Alessandra, Vitale, Antonio, Caggiano, Valeria, Tognetti, Linda, La Marca, Francesca, Sota, Jurgen, Gentileschi, Stefano, Rubegni, Giovanni, Lopalco, Giuseppe, Guerriero, Silvana, Govoni, Marcello, Monti, Sara, Ruscitti, Piero, Angeli, Fabrizio, Carubbi, Francesco, Giacomelli, Roberto, Ciccia, Francesco, Piga, Matteo, Emmi, Giacomo, Costi, Stefania, Sebastiani, Gian Domenico, Iannone, Florenzo, Spedicato, Veronica, Alessio, Giovanni, Ruffilli, Francesca, Milanesi, Alessandra, Gentile, Martina, Crisafulli, Francesca, Alunno, Alessia, Navarini, Luca, Iacono, Daniela, Cauli, Alberto, Ricci, Francesca, Gaggiano, Carla, Tarsia, Maria, Bartoloni, Elena, Conti, Giovanni, Viapiana, Ombretta, Gobbi, Francesca Li, de Paulis, Amato, Parronchi, Paola, Del Giudice, Emanuela, Barone, Patrizia, Olivieri, Alma Nunzia, Bizzi, Emanuele, Maggio, Maria Cristina, Balistreri, Alberto, Frediani, Bruno, Tosi, Gian Marco, Fabiani, Claudia, Rubegni, Pietro, and Cantarini, Luca

Published
2023
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20. Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospectiveItalian P-RHEUM.it study

Author

Carlo Alberto Scirè, Alessandra Bortoluzzi, Andrea Doria, Micaela Fredi, Marcello Govoni, Chiara Tani, Angela Tincani, Maurizio Cutolo, Marta Mosca, Florenzo Iannone, Elena Elefante, Margherita Zen, Maddalena Larosa, Paola Conigliaro, Maria Sole Chimenti, Veronica Codullo, Cecilia Nalli, Veronique Ramoni, Carlomaurizio Montecucco, Marco Taglietti, Valentina Picerno, Greta Carrara, Laura Andreoli, Chiara Marvisi, Carlo Salvarani, Serena Guiducci, Antonio Luca Brucato, Franco Franceschini, Giandomenico Sebastiani, Marta Tonello, Silvia Bellando-Randone, Dina Zucchi, Giovanna Cuomo, Maria Letizia Urban, Maria Gerosa, Ettore Silvagni, Elisa Bellis, Francesca Bellisai, Alessandra Milanesi, Patrizia Rovere-Querini, Ariela Hoxha, Salvatore D'Angelo, Sonia Zatti, Emanuele Bizzi, Gianpiero Landolfi, Bernd Raffeiner, Leonardo Santo, Teresa Del Ross, Maria Stefania Cutro, Giulia Pazzola, Oscar Massimiliano Epis, Sara Benedetti, Maria Favaro, Antonia Calligaro, Annamaria Iuliano, Sabrina Gori, Francesca Crisafulli, Matteo Filippini, Maria Chiara Gerardi, Maria Grazia Lazzaroni, Cecilia Beatrice Chighizola, Laura Trespidi, Maria Chiara Ditto, Cristina Zanardini, Roberta Erra, Melissa Padovan, Irene Mattioli, Davide Rozza, Claudia Lomater, Daniele Lini, Valentina Canti, Rebecca De Lorenzo, Francesca Ruffilli, Giulia Carrea, Ludovica Cavallo, Alessandra Zambon, Claudia Barison, Francesca Serale, Paolo Semeraro, Chiara Loardi, Rossana Orabona, Francesca Ramazzotto, Giulia Fontana, Giorgia Gozzoli, Paola Bizioli, Roberto Felice Caporali, Manuela Wally Ossola, Beatrice Maranini, Danila Morano, Rosita Verteramo, Maria Grazia Anelli, Marlea Lavista, Anna Abbruzzese, Carlo Giuseppe Fasano, Teresa Carbone, Angela Anna Padula, Giuseppina Comitini, Giuseppina Di Raimondo, Clizia Gagliardi, Gloria Crepaldi, Estrella Garcia Gonzalez, Anna Paola Pata, Martina Zerbinati, and Sara Tonetta

Subjects
Medicine
Abstract

Objectives To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it.Methods Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018–2023). Maternal and infant information were collected in a web-based database.Results We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19.6%). Maternal disease flares were observed in 135 (15.6%) pregnancies. 53 (6.1%) pregnancies were induced by assisted reproduction techniques, 61 (7%) ended in miscarriage and 11 (1.3%) underwent elective termination. Obstetrical complications occurred in 261 (30.1%) pregnancies, including 2.3% pre-eclampsia. Two cases of congenital heart block were observed out of 157 pregnancies (1.3%) with anti-Ro/SSA. Regarding treatments, 244 (28.2%) pregnancies were treated with glucocorticoids, 388 (44.8%) with hydroxychloroquine, 85 (9.8%) with conventional synthetic disease-modifying anti-rheumatic drugs and 122 (14.1%) with biological disease-modifying anti-rheumatic drugs. Live births were 794 (91.7%), mostly at term (84.9%); four perinatal deaths (0.5%) occurred. Among 790 newborns, 31 (3.9%) were small-for-gestational-age and 169 (21.4%) had perinatal complications. Exclusive maternal breast feeding was received by 404 (46.7%) neonates. The Edinburgh Postnatal Depression Scale was compiled by 414 women (52.4%); 89 (21.5%) scored positive for emotional distress.Conclusions Multiple factors including preconception counselling and treat-to-target with pregnancy-compatible medications may have contributed to mitigate disease-related risk factors, yielding limited disease flares, good pregnancy outcomes and frequency of complications which were similar to the Italian general obstetric population. Disease-specific issues need to be further addressed to plan preventative measures.

Published
2024
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24. Toolkit für unterschiedliche Zielgruppen

Author

Olbert-Bock, Sibylle, Toscano-Ruffilli, Rosella, Oberholzer, Bernhard, Helfmann, Kerstin, Bischof, Nicole, Ottiger, Astrid, Olbert-Bock, Sibylle, Helfmann, Kerstin, Toscano-Ruffilli, Rosella, Oberholzer, Bernhard, and Bischof, Nicole

Published
2023
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25. Frauen im Top Management

Author

Toscano-Ruffilli, Rosella, Bischof, Nicole, Olbert-Bock, Sibylle, Oberholzer, Bernhard, Olbert-Bock, Sibylle, Helfmann, Kerstin, Toscano-Ruffilli, Rosella, Oberholzer, Bernhard, and Bischof, Nicole

Published
2023
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30. Early prediction of endocrine responsiveness in ER+/HER2-negative metastatic breast cancer (MBC): pilot study with 18F-fluoroestradiol (18F-FES) CT/PET

Author

Malagutti, Bianca, Dib, Bassam, Branni, Carmen, D’Amico, Mauro, Provinciali, Nicoletta, Corradengo, Davide, Fiz, Francesco, Iacozzi, Massimiliano, Rocca, Andrea, Gennari, A., Brain, E., De Censi, A., Nanni, O., Wuerstlein, R., Frassoldati, A., Cortes, J., Rossi, V., Palleschi, M., Alberini, J.L., Matteucci, F., Piccardo, A., Sacchetti, G., Ilhan, H., D’Avanzo, F., Ruffilli, B., Nardin, S., Monti, M., Puntoni, M., Fontana, V., Boni, L., and Harbeck, N.

Published
2024
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36. Development and implementation of the AIDA International Registry for patients with Behçet’s disease

Author

Vitale, Antonio, Della Casa, Francesca, Ragab, Gaafar, Almaghlouth, Ibrahim A., Lopalco, Giuseppe, Pereira, Rosa Maria, Guerriero, Silvana, Govoni, Marcello, Sfikakis, Petros P., Giacomelli, Roberto, Ciccia, Francesco, Monti, Sara, Ruscitti, Piero, Piga, Matteo, Lomater, Claudia, Tufan, Abdurrahman, Opris-Belinski, Daniela, Emmi, Giacomo, Hernández-Rodríguez, José, Şahin, Ali, Sebastiani, Gian Domenico, Bartoloni, Elena, Akkoç, Nurullah, Gündüz, Özgül Soysal, Cattalini, Marco, Conti, Giovanni, Hatemi, Gulen, Maier, Armin, Parronchi, Paola, Del Giudice, Emanuela, Erten, Sukran, Insalaco, Antonella, Li Gobbi, Francesca, Maggio, Maria Cristina, Shahram, Farhad, Caggiano, Valeria, Hegazy, Mohamed Tharwat, Asfina, Kazi Nur, Morrone, Maria, Prado, Leandro L., Dammacco, Rosanna, Ruffilli, Francesca, Arida, Aikaterini, Navarini, Luca, Pantano, Ilenia, Cavagna, Lorenzo, Conforti, Alessandro, Cauli, Alberto, Marucco, Elena Maria, Kucuk, Hamit, Ionescu, Ruxandra, Mattioli, Irene, Espinosa, Gerard, Araújo, Olga, Karkaş, Burak, Canofari, Claudia, Sota, Jurgen, Laymouna, Ahmed Hatem, Bedaiwi, Asma. A., Colella, Sergio, Giardini, Henrique Ayres M., Albano, Valeria, Lo Monaco, Andrea, Fragoulis, George E., Kardas, Riza Can, Berlengiero, Virginia, Hussein, Mohamed A., Ricci, Francesca, La Torre, Francesco, Rigante, Donato, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Tosi, Gian Marco, Dagostin, Marilia Ambiel, Mahmoud, Ayman Abdel-Monem Ahmed, Tarsia, Maria, Alessio, Giovanni, Cimaz, Rolando, Giani, Teresa, Gaggiano, Carla, Iannone, Florenzo, Cipriani, Paola, Mourabi, Mariam, Spedicato, Veronica, Barneschi, Sara, Aragona, Emma, Balistreri, Alberto, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca

Published
2022
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38. The administration of methotrexate in patients with Still's disease, “real-life” findings from AIDA Network Still Disease Registry

Author

Ruscitti, Piero, Sota, Jurgen, Vitale, Antonio, Lopalco, Giuseppe, Iannone, Florenzo, Morrone, Maria, Giardini, Henrique Ayres Mayrink, D'Agostin, Marília Ambuel, Antonelli, Isabelle Parente de Brito, AlMaghlouth, Ibrahim, Asfina, Kazi Nur, Khalil, Najma, Sfikakis, Petros P., Laskari, Katerina, Tektonidou, Maria, Ciccia, Francesco, Iacono, Daniela, Riccio, Flavia, Ragab, Gaafar, Hussein, Mohamed A., Govoni, Marcello, Ruffilli, Francesca, Direskeneli, Haner, Alibaz-Oner, Fatma, Giacomelli, Roberto, Navarrini, Luca, Bartoloni, Elena, Riccucci, Ilenia, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Cipriani, Paola, Cola, Ilenia Di, Hernández-Rodríguez, José, Gómez-Caverzaschi, Verónica, Dagna, Lorenzo, Tomelleri, Alessandro, Makowska, Joanna, Brzezinska, Olga, Iagnocco, Annamaria, Bellis, Elisa, Caggiano, Valeria, Gaggiano, Carla, Tarsia, Maria, Mormile, Ilaria, Emmi, Giacomo, Sfriso, Paolo, Monti, Sara, Erten, Şükran, Giudice, Emanuela Del, Lubrano, Riccardo, Conti, Giovanni, Olivieri, Alma Nunzia, Gullo, Alberto Lo, Tharwat, Samar, Karamanakos, Anastasios, Gidaro, Antonio, Maggio, Maria Cristina, La Torre, Francesco, Cardinale, Fabio, Ogunjimi, Benson, Maier, Armin, Sebastiani, Gian Domenico, Opris-Belinski, Daniela, Frassi, Micol, Viapiana, Ombretta, Bizzi, Emanuele, Carubbi, Francesco, Fotis, Lampros, Tufan, Abdurrahman, Kardas, Riza Can, Więsik-Szewczyk, Ewa, Jahnz-Różyk, Karina, Fabiani, Claudia, Frediani, Bruno, Balistreri, Alberto, Rigante, Donato, and Cantarini, Luca

Published
2023
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40. Association of circulating T lymphocytes and their functional states with pathologic complete response (pCR) in breast cancer (BC). A prospective Italian study.

Author

Ben Ayed, Rahma, primary, Conte, Benedetta, additional, Martini, Veronica, additional, Boldorini, Renzo, additional, Gobbato, Simone, additional, Ruffilli, Beatrice, additional, Vezzoli, Francesca, additional, Alsati, Rami, additional, Negrini, Letizia, additional, Sala, Nicole, additional, Matera, Letizia, additional, Branni, Carmen, additional, Dodaro, Ivan, additional, Gambaro, Anna, additional, Rossi, Valentina, additional, D'Avanzo, Francesca, additional, and Gennari, Alessandra, additional

Published
2024
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47. Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features.

Author

Salamanna, F., Contartese, D., Tedesco, G., Ruffilli, A., Manzetti, M., Viroli, G., Traversari, M., Faldini, C., and Giavaresi, G.

Abstract

Over the past several decades, there has been a notable increase in the total number of spinal fusion procedures worldwide. Advanced spinal fusion techniques, surgical approaches, and new alternatives in grafting materials and implants, as well as autologous cellular therapies, have been widely employed for treating spinal diseases. While the potential of cellular therapies to yield better clinical results is appealing, supportive data are needed to confirm this claim. This meta‐analysis aims to compare the radiographic and clinical outcomes between graft substitutes with autologous cell therapies and graft substitutes alone. PubMed, Scopus, Web of Science, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials were searched for studies comparing graft substitutes with autologous cell therapies and graft substitutes alone up to February 2024. The risk of bias of the included studies was evaluated using the Downs and Black checklist. The following outcomes were extracted for comparison: fusion success, complications/adverse events, Visual Analog Scale (VAS) score, and Oswestry Disability Index (ODI) score. Thirteen studies involving 836 patients were included, with 7 studies considered for the meta‐analysis. Results indicated that the use of graft substitutes with autologous cell therapies demonstrated higher fusion success rates at 3, 6, and 12 months, lower VAS score at 6 months, and lower ODI score at 3, 6, and 12 months. The complication rate was similar between graft substitutes with autologous cell therapies and graft substitutes alone. Although the current literature remains limited, this meta‐analysis suggests that the incorporation of cellular therapies such as bone marrow and platelet derivatives with graft substitutes is associated with a higher fusion rate and significant improvements in functional status and pain following spinal fusion. Future well‐designed randomized clinical trials are needed to definitively assess the clinical effectiveness of cellular therapies in spinal fusion. [ABSTRACT FROM AUTHOR]

Published
2024
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48. SA-ODG platform: a semi-automated and PCR-free method to analyse microRNAs in solid tissues.

Author

Detassis, S., Precazzini, F., Brentari, I., Ruffilli, R., Ress, C., Maglione, A., Pernagallo, S., and Denti, M. A.

Subjects
MICRORNA, TECHNOLOGICAL innovations, TISSUES, BODY fluids, METABOLITES
Abstract

Over the past two decades, numerous techniques have been developed for analysing microRNAs in body fluids and tissues. However, these techniques still face technical challenges, particularly when compared to well-established techniques for proteins and metabolites. Recently, the ODG platform was introduced, which is an innovative technology that allows for the direct detection and quantification of microRNAs in liquid biopsies without requiring extraction or amplification. This study presents the implementation of the ODG platform within a semi-automated protocol to create the "SA-ODG" platform, enhancing the efficiency and precision of microRNA testing while reducing hands-on time required by laboratory staff. For the first time, the SA-ODG platform has been used to directly quantify microRNAs in solid tissues. The results demonstrate precise analysis of miR-122-5p in mouse liver tissues using SA-ODG. These developments represent a crucial step forward in advancing the field of extraction and amplification-free microRNA detection and quantification. [ABSTRACT FROM AUTHOR]

Published
2024
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