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3. Superhydrophobic/superoleophilic magnetic elastomers by laser ablation

Author

Milionis, Athanasios, Fragouli, Despina, Brandi, Fernando, Liakos, Ioannis, Barroso, Suset, Ruffilli, Roberta, and Athanassiou, Athanassia

Subjects
Physics - Applied Physics, Condensed Matter - Soft Condensed Matter
Abstract

We report the development of magnetic nanocomposite sheets with superhydrophobic and superoleophilic surfaces generated by laser ablation. Polydimethylsiloxane elastomer freestanding films, loaded homogeneously with 2% wt. carbon coated iron nanoparticles, were ablated by UV (248 nm), nanosecond laser pulses. The laser irradiation induces chemical and structural changes (both in micro-and nano-scale) to the surfaces of the nanocomposites rendering them superhydrophobic. The use of nanoparticles increases the UV light absorption eficiency of the nanocomposite samples, and thus facilitates the ablation process, since the number of pulses and the laser fluence required are greatly reduced compared to the bare polymer. Additionally the magnetic nanoparticles enhance significantly the super-hydrophobic and oleophilic properties of the PDMS sheets, and provide to PDMS magnetic properties making possible its actuation by a weak external magnetic field. These nanocomposite elastomers can be considered for applications requiring magnetic MEMS for the controlled separation of liquids.

Published
2024
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11. An ecological study shows increased prevalence of autism spectrum disorder in children living in a heavily polluted area

Author

Annamaria Moschetti, Manuela Giangreco, Luca Ronfani, Stefano Cervellera, Maria Pia Ruffilli, Cosimo Nume, Egidio Barbi, and Alessia Giuseppina Servidio

Subjects
Children, Autism spectrum disorder (ASD), Taranto, Prevalence, Pollution, Steel, Medicine, Science
Abstract

Abstract The burden of autism spectrum disorder (ASD) is increasing worldwide with genetic, epigenetic, and environmental factors being possibly responsible for the observed epidemiological figures. In the setting of environmental exposure, the city of Taranto, in Southern Italy, represents an interesting case study as it hosts well inside the city one of the biggest steel plants in Europe. This is a cross-sectional ecological study carried out in the year 2020 in the province of Taranto designed to estimate the burden of ASD in the municipalities of Taranto and Statte, classified as high environmental risk areas (Contaminated Site of National Interest—SIN), compared to the other 27 municipalities of the same province. Differences have been evaluated using the Chi Square Test. Children aged 6–11 years identified in SIN municipalities had a statistically significant higher prevalence of ASD than children of other municipalities (9.58 vs. 6.66/1000 respectively, p = 0.002). No statistically significant difference was observed for the 12–18 years group (3.41 vs. 2.54/1000, p = 0.12). The findings observed in this study are suggestive of the association between urban residential proximity to industrial facilities emitting air pollutants and higher ASD prevalence.

Published
2024
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18. Efficacy of using autologous cells with graft substitutes for spinal fusion surgery: A systematic review and meta‐analysis of clinical outcomes and imaging features

Author

F. Salamanna, D. Contartese, G. Tedesco, A. Ruffilli, M. Manzetti, G. Viroli, M. Traversari, C. Faldini, and G. Giavaresi

Subjects
autologous cell therapies, graft substitutes, meta‐analysis, spinal fusion, Orthopedic surgery, RD701-811
Abstract

Abstract Over the past several decades, there has been a notable increase in the total number of spinal fusion procedures worldwide. Advanced spinal fusion techniques, surgical approaches, and new alternatives in grafting materials and implants, as well as autologous cellular therapies, have been widely employed for treating spinal diseases. While the potential of cellular therapies to yield better clinical results is appealing, supportive data are needed to confirm this claim. This meta‐analysis aims to compare the radiographic and clinical outcomes between graft substitutes with autologous cell therapies and graft substitutes alone. PubMed, Scopus, Web of Science, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials were searched for studies comparing graft substitutes with autologous cell therapies and graft substitutes alone up to February 2024. The risk of bias of the included studies was evaluated using the Downs and Black checklist. The following outcomes were extracted for comparison: fusion success, complications/adverse events, Visual Analog Scale (VAS) score, and Oswestry Disability Index (ODI) score. Thirteen studies involving 836 patients were included, with 7 studies considered for the meta‐analysis. Results indicated that the use of graft substitutes with autologous cell therapies demonstrated higher fusion success rates at 3, 6, and 12 months, lower VAS score at 6 months, and lower ODI score at 3, 6, and 12 months. The complication rate was similar between graft substitutes with autologous cell therapies and graft substitutes alone. Although the current literature remains limited, this meta‐analysis suggests that the incorporation of cellular therapies such as bone marrow and platelet derivatives with graft substitutes is associated with a higher fusion rate and significant improvements in functional status and pain following spinal fusion. Future well‐designed randomized clinical trials are needed to definitively assess the clinical effectiveness of cellular therapies in spinal fusion.

Published
2024
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20. Unfolding dermatologic spectrum of Behçet’s disease in Italy: real-life data from the International AIDA Network Behçet’s disease Registry

Author

D’Onghia, Martina, Cinotti, Elisa, Cartocci, Alessandra, Vitale, Antonio, Caggiano, Valeria, Tognetti, Linda, La Marca, Francesca, Sota, Jurgen, Gentileschi, Stefano, Rubegni, Giovanni, Lopalco, Giuseppe, Guerriero, Silvana, Govoni, Marcello, Monti, Sara, Ruscitti, Piero, Angeli, Fabrizio, Carubbi, Francesco, Giacomelli, Roberto, Ciccia, Francesco, Piga, Matteo, Emmi, Giacomo, Costi, Stefania, Sebastiani, Gian Domenico, Iannone, Florenzo, Spedicato, Veronica, Alessio, Giovanni, Ruffilli, Francesca, Milanesi, Alessandra, Gentile, Martina, Crisafulli, Francesca, Alunno, Alessia, Navarini, Luca, Iacono, Daniela, Cauli, Alberto, Ricci, Francesca, Gaggiano, Carla, Tarsia, Maria, Bartoloni, Elena, Conti, Giovanni, Viapiana, Ombretta, Gobbi, Francesca Li, de Paulis, Amato, Parronchi, Paola, Del Giudice, Emanuela, Barone, Patrizia, Olivieri, Alma Nunzia, Bizzi, Emanuele, Maggio, Maria Cristina, Balistreri, Alberto, Frediani, Bruno, Tosi, Gian Marco, Fabiani, Claudia, Rubegni, Pietro, and Cantarini, Luca

Published
2023
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23. Toolkit für unterschiedliche Zielgruppen

Author

Olbert-Bock, Sibylle, Toscano-Ruffilli, Rosella, Oberholzer, Bernhard, Helfmann, Kerstin, Bischof, Nicole, Ottiger, Astrid, Olbert-Bock, Sibylle, Helfmann, Kerstin, Toscano-Ruffilli, Rosella, Oberholzer, Bernhard, and Bischof, Nicole

Published
2023
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24. Frauen im Top Management

Author

Toscano-Ruffilli, Rosella, Bischof, Nicole, Olbert-Bock, Sibylle, Oberholzer, Bernhard, Olbert-Bock, Sibylle, Helfmann, Kerstin, Toscano-Ruffilli, Rosella, Oberholzer, Bernhard, and Bischof, Nicole

Published
2023
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25. Maladaptive coping styles moderate the relationship between information on cancer treatment and psychosocial symptoms: an Italian multicenter study

Author

L. Zerbinati, F. Folesani, R. Caruso, M. Belvederi Murri, M.G. Nanni, S. Righetti, L. Chiefari, A. Muscettola, T. Toffanin, A. Costantini, B. Zaccagnino, F. Ruffilli, and L. Grassi

Subjects
awareness, cancer, coping strategies, oncology, psychological distress, quality of life, Psychology, BF1-990
Abstract

ObjectivesDisclosing information on diagnosis, prognosis and treatment is a delicate process in oncology, although awareness levels have over time increased in people with cancer. However, individual characteristics should be considered when communicating difficult information. We conducted a multicentric study to explore the moderating role of coping styles on the relationship between information about cancer, quality of life and psychological distress.MethodsIn the period between October 2015 and February 2016, 288 patients with a diagnosis of a solid tumor were recruited from seven Italian oncology units. All participants were administered the Distress Thermometer (DT), the Mini-Mental Adjustment to Cancer (Mini-MAC), the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30), and the EORTC QLQ 25-item information module (INFO25). We explored the moderating effect of coping style with quality of life (QoL) and distress (DT) as dependent variables and information on cancer treatment as independent variable.ResultsLow levels of anxious preoccupation significantly moderated the relationship between information on treatment and QoL (R2 6%, p

Published
2024
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26. Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospectiveItalian P-RHEUM.it study

Author

Carlo Alberto Scirè, Alessandra Bortoluzzi, Andrea Doria, Micaela Fredi, Marcello Govoni, Chiara Tani, Angela Tincani, Maurizio Cutolo, Marta Mosca, Florenzo Iannone, Elena Elefante, Margherita Zen, Maddalena Larosa, Paola Conigliaro, Maria Sole Chimenti, Veronica Codullo, Cecilia Nalli, Veronique Ramoni, Carlomaurizio Montecucco, Marco Taglietti, Valentina Picerno, Greta Carrara, Laura Andreoli, Chiara Marvisi, Carlo Salvarani, Serena Guiducci, Antonio Luca Brucato, Franco Franceschini, Giandomenico Sebastiani, Marta Tonello, Silvia Bellando-Randone, Dina Zucchi, Giovanna Cuomo, Maria Letizia Urban, Maria Gerosa, Ettore Silvagni, Elisa Bellis, Francesca Bellisai, Alessandra Milanesi, Patrizia Rovere-Querini, Ariela Hoxha, Salvatore D'Angelo, Sonia Zatti, Emanuele Bizzi, Gianpiero Landolfi, Bernd Raffeiner, Leonardo Santo, Teresa Del Ross, Maria Stefania Cutro, Giulia Pazzola, Oscar Massimiliano Epis, Sara Benedetti, Maria Favaro, Antonia Calligaro, Annamaria Iuliano, Sabrina Gori, Francesca Crisafulli, Matteo Filippini, Maria Chiara Gerardi, Maria Grazia Lazzaroni, Cecilia Beatrice Chighizola, Laura Trespidi, Maria Chiara Ditto, Cristina Zanardini, Roberta Erra, Melissa Padovan, Irene Mattioli, Davide Rozza, Claudia Lomater, Daniele Lini, Valentina Canti, Rebecca De Lorenzo, Francesca Ruffilli, Giulia Carrea, Ludovica Cavallo, Alessandra Zambon, Claudia Barison, Francesca Serale, Paolo Semeraro, Chiara Loardi, Rossana Orabona, Francesca Ramazzotto, Giulia Fontana, Giorgia Gozzoli, Paola Bizioli, Roberto Felice Caporali, Manuela Wally Ossola, Beatrice Maranini, Danila Morano, Rosita Verteramo, Maria Grazia Anelli, Marlea Lavista, Anna Abbruzzese, Carlo Giuseppe Fasano, Teresa Carbone, Angela Anna Padula, Giuseppina Comitini, Giuseppina Di Raimondo, Clizia Gagliardi, Gloria Crepaldi, Estrella Garcia Gonzalez, Anna Paola Pata, Martina Zerbinati, and Sara Tonetta

Subjects
Medicine
Abstract

Objectives To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it.Methods Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018–2023). Maternal and infant information were collected in a web-based database.Results We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19.6%). Maternal disease flares were observed in 135 (15.6%) pregnancies. 53 (6.1%) pregnancies were induced by assisted reproduction techniques, 61 (7%) ended in miscarriage and 11 (1.3%) underwent elective termination. Obstetrical complications occurred in 261 (30.1%) pregnancies, including 2.3% pre-eclampsia. Two cases of congenital heart block were observed out of 157 pregnancies (1.3%) with anti-Ro/SSA. Regarding treatments, 244 (28.2%) pregnancies were treated with glucocorticoids, 388 (44.8%) with hydroxychloroquine, 85 (9.8%) with conventional synthetic disease-modifying anti-rheumatic drugs and 122 (14.1%) with biological disease-modifying anti-rheumatic drugs. Live births were 794 (91.7%), mostly at term (84.9%); four perinatal deaths (0.5%) occurred. Among 790 newborns, 31 (3.9%) were small-for-gestational-age and 169 (21.4%) had perinatal complications. Exclusive maternal breast feeding was received by 404 (46.7%) neonates. The Edinburgh Postnatal Depression Scale was compiled by 414 women (52.4%); 89 (21.5%) scored positive for emotional distress.Conclusions Multiple factors including preconception counselling and treat-to-target with pregnancy-compatible medications may have contributed to mitigate disease-related risk factors, yielding limited disease flares, good pregnancy outcomes and frequency of complications which were similar to the Italian general obstetric population. Disease-specific issues need to be further addressed to plan preventative measures.

Published
2024
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31. Early prediction of endocrine responsiveness in ER+/HER2-negative metastatic breast cancer (MBC): pilot study with 18F-fluoroestradiol (18F-FES) CT/PET

Author

Malagutti, Bianca, Dib, Bassam, Branni, Carmen, D’Amico, Mauro, Provinciali, Nicoletta, Corradengo, Davide, Fiz, Francesco, Iacozzi, Massimiliano, Rocca, Andrea, Gennari, A., Brain, E., De Censi, A., Nanni, O., Wuerstlein, R., Frassoldati, A., Cortes, J., Rossi, V., Palleschi, M., Alberini, J.L., Matteucci, F., Piccardo, A., Sacchetti, G., Ilhan, H., D’Avanzo, F., Ruffilli, B., Nardin, S., Monti, M., Puntoni, M., Fontana, V., Boni, L., and Harbeck, N.

Published
2024
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35. Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry

Author

Sota, Jurgen, Ragab, Gaafar, AlMaglouth, Ibrahim, Lopalco, Giuseppe, Tufan, Abdurrahman, Direskeneli, Haner, Hinojosa-Azaola, Andrea, Mayrink Giardini, Henrique Ayres, Guerriero, Silvana, Triaggianese, Paola, Sfikakis, Petros P., Piga, Matteo, Ruscitti, Piero, Govoni, Marcello, Iagnocco, Annamaria, Carubbi, Francesco, Hernández-Rodríguez, José, Laymouna, Ahmed Hatem, Mahmoud, Ayman Abdel-Monem Ahmed, Ghanema, Mahmoud, Aboabat, Aos A., Asfina, Kazi Nur, Alanazi, Fehaid, Morrone, Maria, Spedicato, Veronica, Kucuk, Hamit, Kardas, Riza, Alibaz Öner, Fatma, Sevik, Gizem, Torres-Ruiz, Jiram, Kawakami-Campos, Perla Ayumi, Parente de Brito Antonelli, Isabelle, Dammacco, Rosanna, Chimenti, Maria Sole, Arida, Katerina, Floris, Alberto, Gentile, Martina, Ruffilli, Francesca, Bellis, Elisa, Alunno, Alessia, Espinosa, Gerard, Gentileschi, Stefano, Gaggiano, Carla, Vitale, Antonio, Caggiano, Valeria, Lopez, Roberta, Tarsia, Maria, Monti, Sara, Hatemi, Gülen, Karakoç, Alican, Frassi, Micol, Giacomelli, Roberto, Tharwat, Samar, Thabet, Maissa, Ciccia, Francesco, Emmi, Giacomo, Viapiana, Ombretta, Şahin, Ali, Sebastiani, Gian Domenico, Batu, Ezgi Deniz, Ozen, Seza, Sener, Seher, Opris-Belinski, Daniela, Costi, Stefania, Conforti, Alessandro, Cattalini, Marco, Bartoloni, Elena, Akkoç, Nurullah, Gunduz, Ozgul Soysal, Conti, Giovanni, Maier, Armin, Giardina, Annarita, Li Gobbi, Francesca, Parronchi, Paola, Sarzi Puttini, Piercarlo, Breda, Luciana, De Paulis, Amato, Carreño, Ester, La Torre, Francesco, Więsik-Scewczyk, Ewa, de-la Torre, Alejandra, Mejía-Salgado, Germán, Shahram, Farhad, Guiducci, Serena, Maggio, Maria Cristina, Aragona, Emma, Rigante, Donato, Ciavarro, Alessandro, Önen, Fatos, Erten, Şükran, Insalaco, Antonella, Del Giudice, Emanuela, Barone, Patrizia, Gicchino, Francesca, Brucato, Antonio, Lo Gullo, Alberto, Mauro, Angela, Karamanakos, Anastasios, Balistreri, Alberto, Mazzei, Maria Antonietta, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca

Published
2024
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36. Retrograde drilling for ankle joint osteochondral lesions: a systematic review

Author

Elena Artioli, Antonio Mazzotti, Simone Gerardi, Alberto Arceri, Francesca Barile, Marco Manzetti, Giovanni Viroli, Alberto Ruffilli, and Cesare Faldini

Subjects
Drilling, Osteochondral lesions, Ankle, Cartilage, Orthopedic surgery, RD701-811
Abstract

Abstract Background Extensive literature exists about the treatment of ankle osteochondral lesions, but there is no specific review of retrograde drilling, despite its common application. Indications for retrograde drilling are still few and are far from clear, and some evolutions of the technique have recently occurred. The aim of this review is to provide an update on actual applications and techniques of retrograde drilling for ankle osteochondral lesions. Methods A systematic review was carried out according to the 2020 PRISMA guidelines. The PubMed and Embase databases were searched in June 2023. The search string focused on studies related to retrograde drilling in the treatment of ankle osteochondral lesions. Results Twenty-one articles for a total of 271 ankles were included in this review. The mean length of the treated lesions was 11.4 mm. Different navigation systems were used, with fluoroscopy the most commonly used. Various adjuvants were employed after drilling, with bone graft the most commonly applied. In most cases, postoperative patient satisfaction and symptom relief were reported, and no complications occurred. Retrograde drilling was found to be suitable for the treatment of subchondral cysts with intact cartilage or small lesions. Some modifications to the original technique may allow surgical indications to be extended to more complex cases. Conclusions Middle-term results of retrograde drilling showed postoperative satisfaction and symptom relief with both original and modified techniques. Additional research is required to investigate the long-term results. Level of evidence: IV. Trial registration: This systematic review was registered on PROSPERO (id number: CRD42022371128).

Published
2023
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37. P138 Pregnancy outcomes in SLE patients treated with belimumab: the Italian experience

Author

Andrea Doria, Micaela Fredi, Angela Tincani, Margherita Zen, Luca Iaccarino, Cecilia Nalli, Laura Andreoli, Franco Franceschini, Giacomo Emmi, Maria Letizia Urban, Maria Gerosa, Francesca Saccon, Leonardo Santo, Emanuela Praino, Francesca Crisafulli, Maria Chiara Gerardi, Melissa Padovan, Valentina Canti, and Francesca Ruffilli

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2024
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40. The administration of methotrexate in patients with Still's disease, “real-life” findings from AIDA Network Still Disease Registry

Author

Ruscitti, Piero, Sota, Jurgen, Vitale, Antonio, Lopalco, Giuseppe, Iannone, Florenzo, Morrone, Maria, Giardini, Henrique Ayres Mayrink, D'Agostin, Marília Ambuel, Antonelli, Isabelle Parente de Brito, Almaghlouth, Ibrahim, Asfina, Kazi Nur, Khalil, Najma, Sfikakis, Petros P., Laskari, Katerina, Tektonidou, Maria, Ciccia, Francesco, Iacono, Daniela, Riccio, Flavia, Ragab, Gaafar, Hussein, Mohamed A., Govoni, Marcello, Ruffilli, Francesca, Direskeneli, Haner, Alibaz-Oner, Fatma, Giacomelli, Roberto, Navarini, Luca, Bartoloni, Elena, Riccucci, Ilenia, Martín-Nares, Eduardo, Torres-Ruiz, Jiram, Cipriani, Paola, Di Cola, Ilenia, Hernández-Rodríguez, José, Gómez-Caverzaschi, Verónica, Dagna, Lorenzo, Tomelleri, Alessandro, Makowska, Joanna, Brzezinska, Olga, Iagnocco, Annamaria, Bellis, Elisa, Caggiano, Valeria, Gaggiano, Carla, Tarsia, Maria, Mormile, Ilaria, Emmi, Giacomo, Sfriso, Paolo, Monti, Sara, Erten, Şükran, Del Giudice, Emanuela, Lubrano, Riccardo, Conti, Giovanni, Olivieri, Alma Nunzia, Lo Gullo, Alberto, Tharwat, Samar, Karamanakos, Anastasios, Gidaro, Antonio, Maggio, Maria Cristina, La Torre, Francesco, Cardinale, Fabio, Ogunjimi, Benson, Maier, Armin, Sebastiani, Gian Domenico, Opris-Belinski, Daniela, Frassi, Micol, Viapiana, Ombretta, Bizzi, Emanuele, Carubbi, Francesco, Fotis, Lampros, Tufan, Abdurrahman, Kardas, Riza Can, Więsik-Szewczyk, Ewa, Jahnz-Różyk, Karina, Fabiani, Claudia, Frediani, Bruno, Balistreri, Alberto, Rigante, Donato, and Cantarini, Luca

Published
2023
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41. Image-Guided Minimally Invasive Treatment Options for Degenerative Lumbar Spine Disease: A Practical Overview of Current Possibilities

Author

Makoto Taninokuchi Tomassoni, Lorenzo Braccischi, Mattia Russo, Francesco Adduci, Davide Calautti, Marco Girolami, Fabio Vita, Alberto Ruffilli, Marco Manzetti, Federico Ponti, George R. Matcuk, Cristina Mosconi, Luigi Cirillo, Marco Miceli, and Paolo Spinnato

Subjects
low back pain, pain management, lumbar osteoarthritis, intervertebral disc degeneration, interventional ultrasonography, interventional radiology, Medicine (General), R5-920
Abstract

Lumbar back pain is one of the main causes of disability around the world. Most patients will complain of back pain at least once in their lifetime. The degenerative spine is considered the main cause and is extremely common in the elderly population. Consequently, treatment-related costs are a major burden to the healthcare system in developed and undeveloped countries. After the failure of conservative treatments or to avoid daily chronic drug intake, invasive treatments should be suggested. In a world where many patients reject surgery and prefer minimally invasive procedures, interventional radiology is pivotal in pain management and could represent a bridge between medical therapy and surgical treatment. We herein report the different image-guided procedures that can be used to manage degenerative spine-related low back pain. Particularly, we will focus on indications, different techniques, and treatment outcomes reported in the literature. This literature review focuses on the different minimally invasive percutaneous treatments currently available, underlining the central role of radiologists having the capability to use high-end imaging technology for diagnosis and subsequent treatment, allowing a global approach, reducing unnecessary surgeries and prolonged pain-reliever drug intake with their consequent related complications, improving patients’ quality of life, and reducing the economic burden.

Published
2024
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43. Sarcopenia and osteopenia are independent risk factors for proximal junctional disease after posterior lumbar fusion: Results of a retrospective study

Author

Alberto Ruffilli, Francesca Barile, Tosca Cerasoli, Marco Manzetti, Giovanni Viroli, Marco Ialuna, Matteo Traversari, Francesca Salamanna, Antonio Mazzotti, Milena Fini, and Cesare Faldini

Subjects
degenerative disease, osteopenia, proximal junctional disease, sarcopenia, Diseases of the musculoskeletal system, RC925-935
Abstract

Study Design: This was a retrospective study. Objective: Since a better understanding of modifiable risk factors for proximal junctional disease (PJD) may lead to improved postoperative outcomes and less need of revision surgery, the aim of the present study is to determine whether sarcopenia and osteopenia are independent risk factors for PJD in patients undergoing lumbar fusion. Summary of Background Data: PJD is one of the most frequent complications following posterior instrumented spinal fusion. It is characterized by a spectrum of pathologies ranging from proximal junctional kyphosis (PJK) to proximal junctional failure (PJF). The etiology of PJD is multifactorial and currently not fully understood. Patient-specific factors, such as age, body mass index, osteoporosis, sarcopenia, and the presence of other comorbidities, can represent potential risk factors. Materials and Methods: A retrospective review of patients, aging 50–85 years, who underwent a short (≤3 levels) posterior lumbar fusion for degenerative diseases was performed. Through magnetic resonance imaging (MRI), central sarcopenia and osteopenia were evaluated, measuring the psoas-to-lumbar vertebral index (PLVI) and the M-score. A multivariate analysis was performed to determine the independent risk factors for PJD, PJK, and PJF. Results: A total of 308 patients (mean age at surgery 63.8 ± 6.2 years) were included. Ten patients (3.2%) developed a PJD and all required revision surgery. Multivariate regression identified PLVI (P = 0.02) and M-score (P = 0.04) as independent risk factors for both PJK (P = 0.02 and P = 0.04, respectively) and PJF (P = 0.04 and P = 0.01, respectively). Conclusions: Sarcopenia and osteopenia, as measured by PLVI and M-score, proved to be independent risk factors for PJD in patients who undergo lumbar fusion for degenerative diseases. Clinical Trial Registration: The present study was approved by the Institutional Review Board, CE AVEC 208/2022/OSS/IOR.

Published
2023
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45. Development and implementation of the AIDA International Registry for patients with Behçet’s disease

Author

Vitale, Antonio, Della Casa, Francesca, Ragab, Gaafar, Almaghlouth, Ibrahim A., Lopalco, Giuseppe, Pereira, Rosa Maria, Guerriero, Silvana, Govoni, Marcello, Sfikakis, Petros P., Giacomelli, Roberto, Ciccia, Francesco, Monti, Sara, Ruscitti, Piero, Piga, Matteo, Lomater, Claudia, Tufan, Abdurrahman, Opris-Belinski, Daniela, Emmi, Giacomo, Hernández-Rodríguez, José, Şahin, Ali, Sebastiani, Gian Domenico, Bartoloni, Elena, Akkoç, Nurullah, Gündüz, Özgül Soysal, Cattalini, Marco, Conti, Giovanni, Hatemi, Gulen, Maier, Armin, Parronchi, Paola, Del Giudice, Emanuela, Erten, Sukran, Insalaco, Antonella, Li Gobbi, Francesca, Maggio, Maria Cristina, Shahram, Farhad, Caggiano, Valeria, Hegazy, Mohamed Tharwat, Asfina, Kazi Nur, Morrone, Maria, Prado, Leandro L., Dammacco, Rosanna, Ruffilli, Francesca, Arida, Aikaterini, Navarini, Luca, Pantano, Ilenia, Cavagna, Lorenzo, Conforti, Alessandro, Cauli, Alberto, Marucco, Elena Maria, Kucuk, Hamit, Ionescu, Ruxandra, Mattioli, Irene, Espinosa, Gerard, Araújo, Olga, Karkaş, Burak, Canofari, Claudia, Sota, Jurgen, Laymouna, Ahmed Hatem, Bedaiwi, Asma. A., Colella, Sergio, Giardini, Henrique Ayres M., Albano, Valeria, Lo Monaco, Andrea, Fragoulis, George E., Kardas, Riza Can, Berlengiero, Virginia, Hussein, Mohamed A., Ricci, Francesca, La Torre, Francesco, Rigante, Donato, Więsik-Szewczyk, Ewa, Frassi, Micol, Gentileschi, Stefano, Tosi, Gian Marco, Dagostin, Marilia Ambiel, Mahmoud, Ayman Abdel-Monem Ahmed, Tarsia, Maria, Alessio, Giovanni, Cimaz, Rolando, Giani, Teresa, Gaggiano, Carla, Iannone, Florenzo, Cipriani, Paola, Mourabi, Mariam, Spedicato, Veronica, Barneschi, Sara, Aragona, Emma, Balistreri, Alberto, Frediani, Bruno, Fabiani, Claudia, and Cantarini, Luca

Published
2022
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47. Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospective Italian P-RHEUM.it study

Author

Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, Tincani, Angela, Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, and Tincani, Angela

Abstract

Objectives To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. Methods Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. Results We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19.6%). Maternal disease flares were observed in 135 (15.6%) pregnancies. 53 (6.1%) pregnancies were induced by assisted reproduction techniques, 61 (7%) ended in miscarriage and 11 (1.3%) underwent elective termination. Obstetrical complications occurred in 261 (30.1%) pregnancies, including 2.3% pre-eclampsia. Two cases of congenital heart block were observed out of 157 pregnancies (1.3%) with anti-Ro/SSA. Regarding treatments, 244 (28.2%) pregnancies were treated with glucocorticoids, 388 (44.8%) with hydroxychloroquine, 85 (9.8%) with conventional synthetic disease-modifying anti-rheumatic drugs and 122 (14.1%) with biological disease-modifying anti-rheumatic drugs. Live births were 794 (91.7%), mostly at term (84.9%); four perinatal deaths (0.5%) occurred. Among 790 newborns, 31 (3.9%) were small-for-gestational-age and 169 (21.4%) had perinatal complications. Exclusive maternal breast feeding was received by 404 (46.7%) neonates. The Edinburgh Postnatal Depression Scale was compiled by 414 women (52.4%); 89 (21.5%) scored positive for emotional distress. Conclusions Multiple factors including preconception counselling and treat-to-target with pregnancy-compatible medications may have contributed to mitigate disease-related risk factors, yielding limited disease flares, good pregnancy outcomes and frequency of complications which were similar to the Italian general obstetric population. Disease-specific issues need to be further addressed to plan preventative measures.

Published
2024

49. Ponte Osteotomies in the Surgical Treatment of Adolescent Idiopathic Scoliosis: A Systematic Review of the Literature and Meta-Analysis of Comparative Studies

Author

Cesare Faldini, Giovanni Viroli, Matteo Traversari, Marco Manzetti, Marco Ialuna, Francesco Sartini, Alessandro Cargeli, Stefania Claudia Parisi, and Alberto Ruffilli

Subjects
adolescent idiopathic scoliosis, AIS, Ponte osteotomies, posterior column osteotomies, deformity correction, Pediatrics, RJ1-570
Abstract

The purpose of the present paper is to assess if Ponte osteotomies (POs) allow for a better correction in adolescent idiopathic scoliosis (AIS) surgery and to investigate their safety profile. A systematic search of electronic databases was conducted. Inclusion criteria: comparative studies that reported the outcomes of AIS patients who underwent surgical correction through posterior-only approach with and without POs. Clinical and radiographic outcomes were extracted and summarized. Meta-analyses were performed to estimate the differences between patients treated with and without POs. p < 0.05 was considered significant. In total, 9 studies were included. No significant difference in thoracic kyphosis (TK) change between patients treated with and without POs was found (+3.8°; p = 0.06). Considering only hypokyphotic patients, a significant difference in TK change resulted in POs patients (+6.6°; p < 0.01), while a non-significant TK change resulted in normokyphotic patients (+0.2°; p = 0.96). No significant difference in coronal correction (2.5°; p = 0.10) was recorded. Significant estimated blood loss (EBL) (142.5 mL; p = 0.04) and surgical time (21.5 min; p = 0.04) differences were found with POs. Regarding complications rate, the meta-analysis showed a non-significant log odds ratio of 1.1 (p = 0.08) with POs. In conclusion, POs allow for the restoration of TK in hypokyphotic AIS, without a significantly greater TK change in normokyphotic patients, nor a significantly better coronal correction. Considering the significantly greater EBL and the trend toward a higher complications rate, the correct indication for POs is crucial.

Published
2024
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