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Problem: Low response rate to weekly self-reported questionnaires used to obtain athlete health-related and risk exposure data and low compliance with intervention have been reported. We thus aimed to investigate if time to 1) non-response to a weekly questionnaire and 2) non-compliance with an intervention is different among French athletics athletes with different characteristics.Methods: We performed a secondary analysis of data from the PREVATHLE randomized controlled trial including 840 female and male competitive athletics athletes followed over 39-weeks. Using univariate Cox proportional hazards regression models, we analyzed the association between athletes baseline characteristics and the following outcomes: time to failing to (1) respond to a weekly questionnaire and (2) complete a prescribed intervention.Results: Most athletes failed to complete all questionnaires over the 39 weeks (n=672, 80%), athletes in the intervention group, female athletes, younger athletes, athletes performing explosive disciplines, and athletes with higher non-specific sport training failed sooner. Nearly all athletes in the intervention group failed to comply with the intervention (n=443; 98.7%), and the rates were similar amongst athletes with different characteristics. Conclusions: This study shows that novel ways have to be found in order to improve both 1) athletes self-reported responses to weekly questionnaires on health-related and risk exposure data and 2) athletes compliance with an injury risk reduction program. Education and/or digital solutions might be potential opportunities.Key Words: Sports Injury Prevention, Prevention Strategies, Self-Reported Questionnaire, Track and Field

Abstract Background In order to determine whether human prostate can be productively infected by HIV-1 strains with different tropism, and thus represent a potential source of HIV in semen, an organotypic culture of prostate from men undergoing prostatic adenomectomy for benign prostate hypertrophy (BPH) was developed. The presence of potential HIV target cells in prostate tissues was investigated using immunohistochemistry. The infection of prostate explants following exposures with HIV-1 R5, R5X4 and X4 strains was analyzed through the measure of RT activity in culture supernatants, the quantification of HIV DNA in the explants and the detection of HIV RNA+ cells in situ. Results The overall prostate characteristics were retained for 21/2 weeks in culture. Numerous potential HIV-1 target cells were detected in the prostate stroma. Whilst HIV-1 R5SF162 strain consistently productively infected prostatic T lymphocytes and macrophages, the prototypic X4IIIB strain and a primary R5X4 strain showed less efficient replication in this organ. Conclusion The BPH prostate is a site of HIV-1 R5 replication that could contribute virus to semen. A limited spreading of HIV-1 X4 and R5X4 in this organ could participate to the preferential sexual transmission of HIV-1 R5 strains.

Perceptual cognitive skills in real game settings, under conditions of fatigue, such as the ability to gather relevant visual information, are key factors in achieving motor goals in sports. The objectives were to evaluate the effects of acute physical fatigue on gaze behavior during a badminton game (Study 1) and in an unfavorable force ratio situation (Study 2). Six international-level badminton players played two sets and unfavorable force ratio situations while wearing eye-tracking glasses before and after a fatiguing task. During the set, fatiguing physical exercise led to fewer fixations per exchange and more fixations on one area of interest. During unfavorable force ratio situations, fatiguing physical exercise led to shorter fixation durations per exchange, shorter fixation durations on two areas of interest, and longer fixation durations on one area of interest. The results showed that gaze behaviors were adapted in acute physical fatigue conditions to maintain performance. [ABSTRACT FROM AUTHOR]

A widespread increase in tree mortality has been observed around the globe, and this trend is likely to continue because of ongoing climate-induced increases in drought frequency and intensity. This raises the need to identify regions and ecosystems that are likely to experience the most frequent and significant damage. We present SurEau-Ecos, a trait-based, plant hydraulic model designed to predict tree desiccation and mortality at scales from stand to region. SurEau-Ecos draws on the general principles of the SurEau model but introduces a simplified representation of plant architecture and alternative numerical schemes. Both additions were made to facilitate model parameterization and large-scale applications. In SurEau-Ecos, the water fluxes from the soil to the atmosphere are represented through two plant organs (a leaf and a stem, which includes the volume of the trunk, roots and branches) as the product of an interface conductance and the difference between water potentials. Each organ is described by its symplasmic and apoplasmic compartments. The dynamics of a plant's water status beyond the point of stomatal closure are explicitly represented via residual transpiration flow, plant cavitation and solicitation of plants' water reservoirs. In addition to the “explicit” numerical scheme of SurEau, we implemented a “semi-implicit” and “implicit” scheme. Both schemes led to a substantial gain in computing time compared to the explicit scheme (>10 000 times), and the implicit scheme was the most accurate. We also observed similar plant water dynamics between SurEau-Ecos and SurEau but slight disparities in infra-daily variations of plant water potentials, which we attributed to the differences in the representation of plant architecture between models. A global model's sensitivity analysis revealed that factors controlling plant desiccation rates differ depending on whether leaf water potential is below or above the point of stomatal closure. Total available water for the plant, leaf area index and the leaf water potential at 50 % stomatal closure mostly drove the time needed to reach stomatal closure. Once stomata are closed, resistance to cavitation, residual cuticular transpiration and plant water stocks mostly determined the time to hydraulic failure. Finally, we illustrated the potential of SurEau-Ecos to simulate regional drought-induced mortality over France. SurEau-Ecos is a promising tool to perform regional-scale predictions of drought-induced hydraulic failure, determine the most vulnerable areas and ecosystems to drying conditions, and assess the dynamics of forest flammability.

Apneas are associated with many pathological conditions. Here, the authors show in a mouse model that stabilization of the transcription factor Mafa in brainstem GABAergic neurons may contribute to apnea, by decreasing motor drive to muscles controlling the airways.

Hydraulic failure due to xylem embolism has been identified as one of the main mechanisms involved in drought‐induced forest decline. Trees vulnerability to hydraulic failure depends on their hydraulic safety margin (HSM). While it has been shown that HSM globally converges between tree species and biomes, there is still limited knowledge regarding how HSM can adjust locally to varying drought conditions within species. In this study, we relied on three long‐term partial rainfall exclusion experiments to investigate the plasticity of hydraulic traits and HSM for three Mediterranean tree species (Quercus ilex L., Quercus pubescens Willd., and Pinus halepensis Mill.). For all species, a homeostasis of HSM in response to rainfall reduction was found, achieved through different mechanisms. For Q. ilex, the convergence in HSM is attributed to the adjustment of both the turgor loss point (Ψtlp) and the water potential at which 50% of xylem conductivity is lost due to embolism (P50). In contrast, the maintenance of HSM for P. halepensis and Q. pubescens is related to its isohydric behavior for the first and leaf area adjustment for the latter. It remains to be seen whether this HSM homeostasis can be generalized and if it will be sufficient to withstand extreme droughts expected in the Mediterranean region. Summary statement: Mediterranean species submitted to aggravated water stress have maintained their hydraulic safety margin (HSM). For Pinus halepensis and Quercus pubescens, HSM maintenance resulted from their capacity to escape water stress, while it results from the plasticity of Ψtlp and P50 for Quercus ilex. [ABSTRACT FROM AUTHOR]

Key Message: Understanding the impact of extreme drought on the canopy fuel moisture content (CFMC) is crucial to anticipate the effects of climate change on wildfires. Our study demonstrates that foliage mortality, caused by leaf embolism, can substantially diminish CFMC during drought on Pinus halepensis Mill. and Quercus ilex L. It emphasizes the importance of considering plant hydraulics to improve wildfire predictions. Context: Canopy fuel moisture content (CFMC), which represents the water-to-dry mass ratio in leaves and fine twigs within the canopy, is a major factor of fire danger across ecosystems worldwide. CFMC results from the fuel moisture content of living foliage (live fuel moisture content, LFMC) and dead foliage (dead fuel moisture content, DFMC) weighted by the proportion of foliage mortality in the canopy (αDead). Understanding how LFMC, αDead, and ultimately CFMC are affected during extreme drought is essential for effective wildfire planning. Aims: We aimed to understand how plant hydraulics affect CFMC for different levels of soil water deficit, examining its influence on both LFMC and αDead. Methods: We conducted a drought experiment on seedlings of two Mediterranean species: Aleppo pine (Pinus halepensis Mill.) and Holm oak (Quercus ilex L.). Throughout the drought experiment and after rewatering, we monitored CFMC, LFMC, and αDead along with other ecophysiological variables. Results: LFMC exhibited a significant decrease during drought, and as leaf water potentials reached low levels, αDead increased in both species, thereby reducing CFMC. Distinct water use strategies resulted in species-specific variations in dehydration dynamics. Conclusion: Our findings demonstrate that as drought conditions intensify, foliage mortality might become a critical physiological factor driving the decline in CFMC. [ABSTRACT FROM AUTHOR]

The vagal ganglia, comprised of the superior (jugular) and inferior (nodose) ganglia of the vagus nerve, receive somatosensory information from the head and neck or viscerosensory information from the inner organs, respectively. Developmentally, the cranial neural crest gives rise to all vagal glial cells and to neurons of the jugular ganglia, while the epibranchial placode gives rise to neurons of the nodose ganglia. Crest-derived nodose glial progenitors can additionally generate autonomic neurons in the peripheral nervous system, but how these progenitors generate neurons is unknown. Here, we found that some Sox10+ neural crest-derived cells in, and surrounding, the nodose ganglion transiently expressed Phox2b, a master regulator of autonomic nervous system development, during early embryonic life. Our genetic lineage-tracing analysis in mice of either sex revealed that despite their common developmental origin and extreme spatial proximity, a substantial proportion of glial cells in the nodose, but not in the neighboring jugular ganglia, have a history of Phox2b expression. We used single-cell RNA--sequencing to demonstrate that these progenitors give rise to all major glial subtypes in the nodose ganglia, including Schwann cells, satellite glia, and glial precursors, and mapped their spatial distribution by in situ hybridization. Lastly, integration analysis revealed transcriptomic similarities between nodose and dorsal root ganglia glial subtypes and revealed immature nodose glial subtypes. Our work demonstrates that these crest-derived nodose glial progenitors transiently express Phox2b, give rise to the entire complement of nodose glial cells, and display a transcriptional program that may underlie their bipotent nature. [ABSTRACT FROM AUTHOR]

Objective: In Athletics (Track and Field), athletes can be affected by injuries, especially in their quest for top performance. Therefore, we aim to provide an overview of the current knowledge about the problem of injuries in Athletics. Main findings: It is necessary to maintain a clear definition of "injury" when stakeholders in Athletics discuss clinical, administrative, and/or research perspectives. There are several possible methodological approaches to collect injury data in Athletics depending on the context, population, and injury definition. In general, about two thirds of Athletics athletes sustain at least one injury during an Athletics season, and there are about 100 injuries per 1000 registered athletes during an international championship. The injury rates and characteristics vary by sex and discipline. The injuries can affect athletes physically, psychologically, and socially, with short- and long-term consequences for musculoskeletal function, athletics performance and athletics career. Although it is logical to try to reduce the injury risk, little scientific evidence is currently available to help Athletics-related stakeholders. Conclusions: Injury can currently be considered as an omnipresent problem in Athletics, which affects their practice, with consequences on performance and health. Injury risk is today an undeniable part of the life of Athletics athletes, which implies that there is a pressing need to continue the development of injury risk reduction strategies, to scientifically evaluate their efficacy, and to implement them in sports practice. [ABSTRACT FROM AUTHOR]

Abstract Under the influence of climate change, wildfire regimes are expected to intensify and expand to new areas, increasing threats to natural and socioeconomic assets. We explore the environmental and economic implications for the forest sector of climate‐induced changes in wildfire regimes. To retain genericity while considering local determinants, we focus on the regional level and take Mediterranean France as an example. Coupling a bioeconomic forest sector model and a model of wildfire activity, we perform spatially explicit simulations under various levels of radiative forcing. By using a probabilistic framework, we also assess the propagation of several sources of uncertainty to the forest sector, considering both climate‐induced uncertainty and the intrinsic stochasticity of the fire process. By the end of the century, summer burned areas increase by up to 55%, causing moderate losses of merchantable timber and forest carbon stocks, with cascading impacts for industrial activities and climate mitigation in the forest sector. Implications for industries remain limited, but we observe price increases, especially for softwoods, as well as spatially differentiated changes in producer welfare. Inter‐annual fluctuations explain most of uncertainty in wildfire activity, but their impacts on the forest sector are quickly dampened. Over time, owing to the cumulative nature of wildfire impacts on forest resources, uncertainty related to climate warming, climate models’ response and stochasticity intrinsic to the wildfire phenomenon strongly increase in relative importance. Results reassert the need to consider multiple futures in prospective assessments, including uncertainty inherent to natural processes, often omitted in large‐scale economic assessments.

In regular times, implementing exercise-based injury prevention programs into the training routine of high-level and professional athletes represents a key and challenging aspect to decrease injury risk. Barriers to implementing such prevention programs have previously been identified such as lack of resources, logistic issues or motivation. The COVID-19 pandemic associated with restrictions on daily life dramatically impacted sports participation from training to competition. It is therefore reasonable to assume that such lockdown-like context has exacerbated the challenge to implement exercise-based injury prevention programs, potentially leading to a greater musculoskeletal injury risk. In this narrative review, recommendations are proposed for building an expertise- and evidence-based Standard Operating Procedure for injury prevention in lockdown-like contexts for high-level and professional athletes. The following recommendations can be provided: (1) assess the global and sport-specific risks in the light of the ongoing cause of isolation; (2) adapt remote training materials and programs; (3) ensure regular quality communication within the staff, between athletes and the staff as well as between athletes; (4) follow the athlete's mental well-being; and (5) plan for a safe return-to-sports as well as for an ongoing monitoring of the load-recovery balance. These key domains should further be addressed to comply with local policies, which are subject to change over time in each individual country. The use of these recommendations may improve the readiness of athletes, coaches, physicians and all sports stakeholders for future lockdown-like contexts.

In badminton, the ability to quickly gather relevant visual information is one of the most important determinants of performance. However, gaze behavior has never been investigated in a real-game setting (with fatigue), nor related to performance. The aim of this study was to evaluate the effect of fatigue on gaze behavior during a badminton game setting, and to determine the relationship between fatigue, performance and gaze behavior. Nineteen novice badminton players equipped with eye-tracking glasses played two badminton sets: one before and one after a fatiguing task. The duration and number of fixations for each exchange were evaluated for nine areas of interest. Performance in terms of points won or lost and successful strokes was not impacted by fatigue, however fatigue induced more fixations per exchange on two areas of interest (shuttlecock and empty area after the opponent's stroke). Furthermore, two distinct gaze behaviors were found for successful and unsuccessful performance: points won were associated with fixations on the boundary lines and few fixation durations on empty area before the participant's stroke; successful strokes were related to long fixation durations, few fixation durations on empty area and a large number of fixations on the shuttlecock, racket, opponent's upper body and anticipation area. This is the first study to use a mobile eye-tracking system to capture gaze behavior during a real badminton game setting: fatigue induced changes in gaze behavior, and successful and unsuccessful performance were associated with two distinct gaze behaviors.