10 results on '"Ruff JR"'
Search Results
2. Going deep
- Author
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Sittig, Micah, Priego, Ernesto, and Ruff, Jr., Ed
- Subjects
Mass communications ,Publishing industry - Abstract
Bree Nordenson has done a great job synthesizing a great deal of information into a first-rate piece of explanatory journalism ('Overload' CJR, November/ December). She has done her homework and [...]
- Published
- 2009
3. THE STACKING-FAULT ENERGY IN α-SILVER – TIN ALLOYS
- Author
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Ruff Jr., A. W., primary and Ives, L. K., additional
- Published
- 1967
- Full Text
- View/download PDF
4. A Simple Way To Maintain Turbocharged Engines.
- Author
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Ruff Jr., Guy
- Subjects
TURBOCHARGERS ,DIESEL aircraft engines ,DIESEL motor maintenance & repair ,PRESSURE transducers ,OIL changes ,MAINTENANCE - Abstract
The article offers tips on how to properly maintain turbocharged diesel engines for airplanes. The author mentions that it is important to be familiar with the engine and use pressure sensors to be aware of engine problems. He states that the best way to maintain a turbocharged engine is to change the oil often, as turbochargers need high quality oil.
- Published
- 2012
5. LETTERS.
- Author
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Ruff Jr., Ed
- Subjects
- *
LETTERS to the editor , *NEWS audiences - Abstract
A letter to the editor is presented regarding the article "Overload" by Bree Nordenson in the November/December 2008 issue.
- Published
- 2009
6. Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity.
- Author
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Antunes MS, Jesse CR, Ruff JR, de Oliveira Espinosa D, Gomes NS, Altvater EET, Donato F, Giacomeli R, and Boeira SP
- Subjects
- Animals, Behavior, Animal drug effects, Hesperidin therapeutic use, Hippocampus metabolism, Hippocampus physiopathology, Male, Maze Learning drug effects, Mice, Olfactory Bulb surgery, Acetylcholinesterase metabolism, Brain-Derived Neurotrophic Factor metabolism, Cognition drug effects, Cytokines metabolism, Depression drug therapy, Hesperidin pharmacology, Hippocampus drug effects
- Abstract
Depression is a serious mental disorder that is becoming more common. To better treat patients suffering from this illness, elucidation of the underlying psychopathological and neurobiological mechanisms of depression is needed. Based on the evidence, we sought to investigate the effects of hesperidin in a model of depression induced by olfactory bulbectomy (OB). C57BL/6 mice were treated with hesperidin (50mg/kg) and imipramine (10mg/kg, positive control) after OB induction. The brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), interleukin 1β (IL-1β) and interleukin 6 (IL-6) levels and acetylcholinesterase activity were analyzed in the hippocampus of the mice. The behavioral parameters were also verified in the model of depression induced by OB. This study demonstrated that OB increased the pro-inflammatory cytokines levels and acetylcholinesterase activity in the hippocampus, exploratory activity in the open field test and immobility in the forced swimming test in mice. In addition, OB decreased the BDNF and NGF levels in the hippocampus, grooming time in the splash test and memory consolidation in the Morris water maze task. Treatment with hesperidin, similar to imipramine, was effective in preventing these behavioral and neurochemical alterations. We suggest that the main targets of hesperidin are pro-inflammatory cytokine modulation, helping to maintain brain plasticity and acetylcholinesterase activity regulation, which are closely linked with antidepressant-like action, as shown by behavior tests. This study demonstrated that there is a pharmacological effect of hesperidin in alterations induced by OB in mice, indicating that hesperidin could be useful as a treatment for depression., (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
7. Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice.
- Author
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Souza LC, Jesse CR, Antunes MS, Ruff JR, de Oliveira Espinosa D, Gomes NS, Donato F, Giacomeli R, and Boeira SP
- Subjects
- Amyloid beta-Peptides administration & dosage, Animals, Disease Models, Animal, Indoleamine-Pyrrole 2,3,-Dioxygenase drug effects, Injections, Intraventricular, Mice, Peptide Fragments administration & dosage, Recognition, Psychology drug effects, Amyloid beta-Peptides pharmacology, Anxiety chemically induced, Behavior, Animal drug effects, Depression chemically induced, Hippocampus drug effects, Indoleamine-Pyrrole 2,3,-Dioxygenase metabolism, Inflammation chemically induced, Kynurenine drug effects, Memory Disorders chemically induced, Nerve Growth Factors drug effects, Peptide Fragments pharmacology, Prefrontal Cortex drug effects, Tryptophan drug effects
- Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by a progressive cognitive decline along with various neuropsychiatric symptoms, including depression and anxiety. Increasing evidence has been proposed the activation of the tryptophan-degrading indoleamine-2,3-dyoxigenase (IDO), the rate-limiting enzyme of kynurerine pathway (KP), as a pathogenic factor of amyloid-beta (Aβ)-related inflammation in AD. In the current study, the effects of an intracerebroventricular (i.c.v.) injection of Aβ1-42 peptide (400pmol/mice; 3μl/site) on the regulation of KP biomarkers (IDO activity, tryptophan and kynurerine levels) and the impact of Aβ1-42 on neurotrophic factors levels were investigated as potential mechanisms linking neuroinflammation to cognitive/emotional disturbances in mice. Our results demonstrated that Aβ1-42 induced memory impairment in the object recognition test. Aβ1-42 also induced emotional alterations, such as depressive and anxiety-like behaviors, as evaluated in the tail suspension and elevated-plus maze tests, respectively. We observed an increase in levels of proinflammatory cytokines in the Aβ1-42-treated mice, which led to an increase in IDO activity in the prefrontal cortex (PFC) and the hippocampus (HC). The IDO activation subsequently increased kynurerine production and the kynurenine/tryptophan ratio and decreased the levels of neurotrophic factors in the PFC and HC, which contributed to Aβ-associated behavioral disturbances. The inhibition of IDO activation by IDO inhibitor 1-methyltryptophan (1-MT), prevented the development of behavioral and neurochemical alterations. These data demonstrate that brain IDO activation plays a key role in mediating the memory and emotional disturbances in an experimental model based on Aβ-induced neuroinflammation., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
8. Neuropeptide Y administration reverses tricyclic antidepressant treatment-resistant depression induced by ACTH in mice.
- Author
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Antunes MS, Ruff JR, de Oliveira Espinosa D, Piegas MB, de Brito ML, Rocha KA, de Gomes MG, Goes AT, Souza LC, Donato F, Boeira SP, and Jesse CR
- Subjects
- Animals, Corticosterone blood, Depressive Disorder blood, Disease Models, Animal, Female, Hippocampus drug effects, Hippocampus metabolism, Hydroxyindoleacetic Acid blood, Indoleamine-Pyrrole 2,3,-Dioxygenase metabolism, Mice, Mice, Inbred C57BL, Neuropeptide Y administration & dosage, Swimming physiology, Adrenocorticotropic Hormone, Antidepressive Agents, Tricyclic therapeutic use, Depressive Disorder chemically induced, Depressive Disorder drug therapy, Drug Resistance drug effects, Neuropeptide Y pharmacology
- Abstract
Depression is one of the most common mental disorders and a primary cause of disability. To better treat patients suffering this illness, elucidation of the underlying psychopathological and neurobiological mechanisms is urgently needed. Based on the above-mentioned evidence, we sought to investigate the effects of neuropeptide Y (NPY) treatment in tricyclic antidepressant treatment-resistant depression induced by adrenocorticotropic hormone (ACTH) administration. Mice were treated with NPY (5.84, 11.7 or 23.4mmol/μl) intracerebroventricularly (i.c.v.) for one or five days. The levels of serum corticosterone, tryptophan (TRP), kynurenine (KYN), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and indoleamine 2,3-dioxygenase (IDO) activity in the hippocampus were analyzed. The behavioral parameters (depressive-like and locomotor activity) were also verified. This study demonstrated that ACTH administration increased serum corticosterone levels, KYN, 5-HIAA levels, IDO activity (hippocampus), immobility in the forced swimming test (FST) and the latency to feed in the novelty suppressed feeding test (NSFT). In addition, ACTH administration decreased the BDNF and NGF levels in the hippocampus of mice. NPY treatment was effective in preventing these hormonal, neurochemical and behavioral alterations. It is suggested that the main target of NPY is the modulation of corticosterone and neuronal plasticity protein levels, which may be closely linked with pharmacological action in a model of tricyclic antidepressant treatment-resistant depression. Thus, this study demonstrated a protective effect of NPY on the alterations induced by ACTH administration in mice, indicating that it could be useful as a therapy for the treatment of tricyclic antidepressant treatment-resistant depression., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
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9. Ostracism Online: A social media ostracism paradigm.
- Author
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Wolf W, Levordashka A, Ruff JR, Kraaijeveld S, Lueckmann JM, and Williams KD
- Subjects
- Adult, Bayes Theorem, Behavioral Research methods, Humans, Psychological Distance, Psychology, Social methods, Social Media, Surveys and Questionnaires, Crowdsourcing methods, Crowdsourcing standards, Interpersonal Relations
- Abstract
We describe Ostracism Online, a novel, social media-based ostracism paradigm designed to (1) keep social interaction experimentally controlled, (2) provide researchers with the flexibility to manipulate the properties of the social situation to fit their research purposes, (3) be suitable for online data collection, (4) be convenient for studying subsequent within-group behavior, and (5) be ecologically valid. After collecting data online, we compared the Ostracism Online paradigm with the Cyberball paradigm (Williams & Jarvis Behavior Research Methods, 38, 174-180, 2006) on need-threat and mood questionnaire scores (van Beest & Williams Journal of Personality and Social Psychology 91, 918-928, 2006). We also examined whether ostracized targets of either paradigm would be more likely to conform to their group members than if they had been included. Using a Bayesian analysis of variance to examine the individual effects of the different paradigms and to compare these effects across paradigms, we found analogous effects on need-threat and mood. Perhaps because we examined conformity to the ostracizers (rather than neutral sources), neither paradigm showed effects of ostracism on conformity. We conclude that Ostracism Online is a cost-effective, easy to use, and ecologically valid research tool for studying the psychological and behavioral effects of ostracism.
- Published
- 2015
- Full Text
- View/download PDF
10. Environmental laws in health care.
- Author
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Ruff GG Jr
- Subjects
- Asbestos standards, Disaster Planning legislation & jurisprudence, Environmental Exposure prevention & control, Ethylene Oxide standards, Fires prevention & control, Liability, Legal, Medical Waste legislation & jurisprudence, United States, Water standards, Environmental Exposure legislation & jurisprudence, Hazardous Waste legislation & jurisprudence, Maintenance and Engineering, Hospital legislation & jurisprudence, Refuse Disposal legislation & jurisprudence
- Abstract
Federal and state regulations regarding the management and disposal of medical waste are currently quite extensive and will only become more comprehensive in the future. The public's heightened awareness and concerns over infectious diseases and discoveries of medical waste on beaches in New Jersey, Alabama, and other states, as well as medical waste being found in open trash bins and at public landfills, has brought to the public's attention the need for governmental intervention into this growing area of concern. Because regulations originating from the local, state, and federal levels have the potential to significantly affect hospitals, it is important that a specific person or department within the organization have a clearly designated responsibility to stay informed and follow up on these regulations. The designated person or department must work closely with the hospital's attorney to make sure that he or she stays current on environmental laws and keeps the institution adequately advised of its legal responsibilities.
- Published
- 1992
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