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27 results on '"Ruehl-Fehlert, Christine"'

2. Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia

Author

Zhao, Xiao-Yan, Wilmen, Andreas, Wang, Dongli, Wang, Xinquan, Bauzon, Maxine, Kim, Ji-Yun, Linden, Lars, Li, Liang, Egner, Ursula, Marquardt, Tobias, Moosmayer, Dieter, Tebbe, Jan, Glück, Julian Marius, Ellinger, Philipp, McLean, Kirk, Yuan, Shujun, Yegneswaran, Subramanian, Jiang, Xiaoqiao, Evans, Vince, Gu, Jian-Ming, Schneider, Doug, Zhu, Ying, Xu, Yifan, Mallari, Cornell, Hesslein, Ashley, Wang, Yan, Schmidt, Nicole, Gutberlet, Katrin, Ruehl-Fehlert, Christine, Freyberger, Alexius, Hermiston, Terry, Patel, Chandra, Sim, Derek, Mosnier, Laurent O., and Laux, Volker

Published
2020
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3. List of Contributors

Author

Alden, Carl L., primary, Berridge, Brian R., additional, Bolon, Brad, additional, Bounous, Denise I., additional, Butt, Mark T., additional, Cattley, Russell C., additional, Chapin, Robert E., additional, Chebekoue, Sandrine F., additional, Creasy, Dianne M., additional, Cullen, John M., additional, Danilenko, Dimitry M., additional, Davis, Barbara, additional, Diegel, Kelly L., additional, Dorman, David C., additional, Dubielzig, Richard R., additional, Elmore, Susan A., additional, Fenton, Suzanne E., additional, Ferguson, Duncan C., additional, Foley, George L., additional, Garman, Robert H., additional, Gropp, Kathryn E., additional, Gunson, Diane, additional, Hard, Gordon C., additional, Harkema, Jack R., additional, Haschek, Wanda M., additional, Herman, Eugene, additional, Hoenerhoff, Mark J., additional, Janovitz, Evan B., additional, Khan, Kanwar N.M., additional, Krishnan, Kannan, additional, Kuper, C. Frieke, additional, Lehman-McKeeman, Lois D., additional, Li, Xiantang, additional, Malarkey, David E., additional, Maronpot, Robert R., additional, Nikula, Kristen J., additional, Ochoa, Ricardo, additional, Parker, George A., additional, Ramaiah, Lila, additional, Rousseaux, Colin G., additional, Rudmann, Daniel G., additional, Ruehl-Fehlert, Christine, additional, Ruepp, Stefan U., additional, Schafer, Kenneth A., additional, Sullivan, John M., additional, Teixeira, Leandro, additional, Van Vleet, John F., additional, Varela, Aurore, additional, Wallig, Matthew A., additional, and Wojcinski, Zbigniew W., additional

Published
2018
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4. Immune System

Author

Ruehl-Fehlert, Christine, primary, Parker, George A., additional, Elmore, Susan A., additional, and Kuper, C. Frieke, additional

Published
2018
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8. Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies: A Guide for Investigators, Authors, Reviewers, and Readers

Author

Wolf, Jeffrey C., Baumgartner, Wes A., Blazer, Vicki S., Camus, Alvin C., Engelhardt, Jeffery A., Fournie, John W., Frasca, Salvatore, Jr., Groman, David B., Kent, Michael L., Khoo, Lester H., Law, Jerry M., Lombardini, Eric D., Ruehl-Fehlert, Christine, Segner, Helmut E., Smith, Stephen A., Spitsbergen, Jan M., Weber, Klaus, and Wolfe, Marilyn J.

Published
2015
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9. Contributors

Author

Adams, E. Terence, primary, Adler, Rick, additional, Alden, Carl L., additional, Bartholomew, Phillip M., additional, Basu, Joydeep, additional, Beasley, Val R., additional, Berridge, Brian R., additional, Bertram, Timothy A., additional, Bhang, Hyo-eun, additional, Black, Hugh E., additional, Bolon, Brad, additional, Boorman, Gary A., additional, Bounous, Denise I., additional, Boyce, Rogely Waite, additional, Bracken, William M., additional, Brix, Amy E., additional, Brown, Danielle, additional, Butt, Mark T., additional, Cantor, Glenn H., additional, Car, Bruce D., additional, Castranova, Vincent, additional, Cattley, Russell C., additional, Chan, Curtis, additional, Chapin, Robert E., additional, Cohen, Samuel M., additional, Colegate, Steve, additional, Cook, Daniel, additional, Cooke, Paul S., additional, Crabbs, Torrie A., additional, Creasy, Dianne M., additional, Crissman, James W., additional, Cullen, John M., additional, Danilenko, Dimitry M., additional, Davis, Barbara, additional, Davis, Myrtle A., additional, Davis, T. Zane, additional, DeLellis, Ronald A., additional, Denslow, Nancy D., additional, Diegel, Kelly L., additional, Dorman, David C., additional, Dubielzig, Richard R., additional, Durham, Stephen K., additional, Eldridge, Sandy, additional, Elmore, Susan A., additional, Everitt, Jeffrey I., additional, Fenton, Suzanne, additional, Ferguson, Duncan C., additional, Field, Reuel, additional, Foley, George L., additional, Foster, William R., additional, Frantz, Jerry D., additional, Gabrielson, Kathy, additional, Gad, Shayne C., additional, Galbreath, Elizabeth J., additional, Gardner, Dale R., additional, Garman, Robert H., additional, Gill, Santokh, additional, Glerup, Peter, additional, Goad, Dale L., additional, Pecquet Goad, Mary Elizabeth, additional, Grand, Nanna, additional, Green, Benjamin T., additional, Gropp, Kathryn E., additional, Gundersen, Hans Jørgen G., additional, Gunson, Diane, additional, Gupta, Ramesh C., additional, Gwaltney-Brant, Sharon M., additional, Hall, Jeffery O., additional, Halpern, Wendy, additional, Hard, Gordon C., additional, Hardisty, Jerry F., additional, Harkema, Jack R., additional, Harvey, Philip W., additional, Haschek, Wanda M., additional, Heinz-Taheny, Kathleen, additional, Herbert, Ronald A., additional, Herman, Eugene, additional, Hoenerhoff, Mark, additional, Hubbs, Ann, additional, Hutto, David, additional, Janovitz, Evan B., additional, Khan, Kanwar Nasir M., additional, Keenan, Kevin P., additional, Kerlin, Roy L., additional, Kreeger, John M., additional, Krishnan, Kannan, additional, Kuper, C. Frieke, additional, Lee, Stephen T., additional, Lehman-McKeeman, Lois D., additional, Li, Xiantang, additional, Lombardini, Eric D., additional, Louden, Calvert, additional, Ludlow, John W., additional, Malarkey, David E., additional, Mann, Peter C., additional, Maronpot, Robert R., additional, McDorman, Kevin S., additional, Melanson, Mark A., additional, Mercer, Robert, additional, Mirabile, Rosanna, additional, Moch, Ronald W., additional, Morrison, James P., additional, Morton, Daniel, additional, Morton, Laura Dill, additional, Muthupalani, Sureshkumar, additional, Nikula, Kristen J., additional, Ochoa, Ricardo, additional, Pacheco-Thompson, Michelle E., additional, Pulido, Olga M., additional, Panter, Kip E., additional, Parker, George A., additional, Porter, Dale W., additional, Patterson, Douglas Reid, additional, Pfister, James A., additional, Pinkert, Carl A., additional, Ramaiah, Lila, additional, Rao, Deepa B., additional, Robertson, Donald G., additional, Rojko, Jennifer, additional, Rosol, Thomas J., additional, Rousseaux, Colin G., additional, Rudmann, Daniel G., additional, Ruehl-Fehlert, Christine, additional, Sargent, Linda, additional, Satterwhite, Christina M., additional, Schafer, Kenneth A., additional, Solter, Philip F., additional, Sills, Robert C., additional, Simon, Liz, additional, Skydsgaard, Mikala, additional, Smith, Graham S., additional, Sriram, Krishnan, additional, Stegelmeier, Bryan L., additional, Sullivan, John M., additional, Sutcliffe, Catherine, additional, Swenberg, James A., additional, Sysa-Shah, Polina, additional, Teixeira, Leandro, additional, Tsuchiya, Noriko, additional, Vahle, John L., additional, Van Vleet, John F., additional, Varela, Aurore, additional, Voss, Kenneth A., additional, Walker, Robin M., additional, Wallig, Matthew A., additional, Walter, Gail L., additional, Welch, Kevin D., additional, White, Paul, additional, Winkelmann, Christopher T., additional, Wojcinski, Zbigniew W., additional, and Wolf, Jeffrey C., additional

Published
2013
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10. Immune System

Author

Kuper, C. Frieke, primary, Ruehl-Fehlert, Christine, additional, Elmore, Susan A., additional, and Parker, George A., additional

Published
2013
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14. Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies

Author

Wolf, Jeffrey C., primary, Baumgartner, Wes A., additional, Blazer, Vicki S., additional, Camus, Alvin C., additional, Engelhardt, Jeffery A., additional, Fournie, John W., additional, Frasca, Salvatore, additional, Groman, David B., additional, Kent, Michael L., additional, Khoo, Lester H., additional, Law, Jerry M., additional, Lombardini, Eric D., additional, Ruehl-Fehlert, Christine, additional, Segner, Helmut E., additional, Smith, Stephen A., additional, Spitsbergen, Jan M., additional, Weber, Klaus, additional, and Wolfe, Marilyn J., additional

Published
2014
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17. ESTP comments on the draft updated OECD test guideline 407

Author

Hartmann, Elke, primary, Strauss, Volker, additional, Eiben, Rolf, additional, Freyberger, Alexius, additional, Kaufmann, Wolfgang, additional, Loof, Ingo, additional, Reissmueller, Elke, additional, Rinke, Matthias, additional, Ruehl-Fehlert, Christine, additional, Schorsch, Frederic, additional, and Schladt, Ludwig, additional

Published
2008
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24. Regulatory aspects of immunotoxicology.

Author

Schulte, Agnes and Ruehl-Fehlert, Christine

Subjects
TOXICOLOGY, PREVENTIVE medicine, VACCINATION, FOOD additives
Abstract

Abstract: Since years, differences among the regulatory requirements on preclinical immunotoxicity testing for pharmaceuticals in the EU, Japan and US indicated a need for an internationally accepted approach. Requests for immunotoxicity investigations are also addressed by guidelines in non-drug areas. While some contain more detailed information in their requirements, other regulations comprise only vague descriptions for consideration of (non-intended) effects on the immune effects. Since 2002, the International Conference on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use put effort in the development of a harmonised approach for testing of immunosuppression and immunoenhancement. Consensus on the ICH S8 guideline on immunotoxicity testing for pharmaceuticals was achieved which now can be implemented into national regulations. The new concept contains in-depth testing, e.g., by functional tests in a concern/weight of evidence approach if the standard toxicity studies or other causes of concern give evidence of an immunotoxic potential or when the target populations are specifically vulnerable. It is expected that the progress on immunotoxicity testing reached by the ICH process will also have an impact on other regulatory areas. Additionally, the regulatory differences in testing requirements on immunotoxicity in other pharmaceutical areas including biotechnology-derived drugs, medicinal products and vaccines and in non-drug areas consisting of chemicals, agrochemicals or food additives are briefly highlighted. [Copyright &y& Elsevier]

Published
2006
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25. Revised guides for organ sampling and trimming in rats and mice – Part 3: A joint publication of the RITA 1 )and NACAD 2 )groups.

Author

Morawietz, Gerd, Ruehl-Fehlert, Christine, Kittel, Birgit, Bube, Axel, Keane, Kevin, Halm, Sabine, Heuser, Anke, and Hellmann, Jürgen

Subjects
ORGANS (Anatomy), PRESERVATION of organs, tissues, etc., TISSUES, RATS
Abstract

Summary: This is the third part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies, covering the urinary, nervous, musculoskeletal, cardiovascular, and lymphoreticular systems. The article is based on the experience of the European RITA and American NACAD working groups and is an extended revision of trimming guides published in 1995 (Bahnemannet al.). The optimum localization for tissue preparation, the sample size, the direction of sectioning and the number of sections to be prepared is described organ by organ. These descriptions are illustrated for each organ by a schematic drawing and/or a macro-photograph showing the plane of section as well as a low magnification of the H&E stained slide demonstrating the optimum “end-product”. The objectives of this work, as addressed in detail in the first part (Ruehl-Fehlert et al. 2003), are to standardize tissue sampling and trimming for comparison of historical data obtained from different studies and different laboratories, ensure the presence of all relevant target sites for histopathological evaluation and provide technical advice for preparatory techniques during necropsy, fixation and trimming (Crissmanet al. 2004). [Copyright &y& Elsevier]

Published
2004
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26. Revised guides for organ sampling and trimming in rats and mice – Part 2: A joint publication of the RITA 1 )and NACAD 2 )groups.

Author

Kittel, Birgit, Ruehl-Fehlert, Christine, Morawietz, Gerd, Klapwijk, Jan, Elwell, Michael R., Lenz, Barbara, O'Sullivan, M. Gerard, Roth, Daniel R., and Wadsworth, Peter F.

Subjects
ORGANS (Anatomy), PRESERVATION of organs, tissues, etc., TISSUES, RATS
Abstract

Summary: This is the second part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies, covering the respiratory, male and female genital, and the endocrine systems. The article is based on the experience of the European RITA and American NACAD working groups and is an extended revision of trimming guides published in 1995 (Bahnemann et al.). The optimum localization for tissue preparation, the sample size, the direction of sectioning and the number of sections to be prepared is described organ by organ. These descriptions are illustrated for each organ by a schematic drawing and/or a macro-photograph showing the plane of section as well as a low magnification of the H&E stained slide demonstrating the optimum “end-product”. The objectives of this work, as addressed in detail in the first part (Ruehl-Fehlert et al. 2003), are to standardize tissue sampling and trimming, to improve the comparability of historical data obtained from different studies and different laboratories, ensure the presence of all relevant target sites for histopathological evaluation and provide technical advice for preparatory techniques during necropsy, fixation and trimming. [Copyright &y& Elsevier]

Published
2004
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