25 results on '"Rudyk, Iurii"'
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2. The associations of cytokines and gens polymorphisms of β-adrenoceptors in patients with heart failure and some thyroid pathology (literature review and own observations)
- Author
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Pyvovar, Sergiy M., primary, Rudyk, Iurii, additional, and Scherban, Tetiana D, additional
- Published
- 2024
- Full Text
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3. THE ASSOCIATIONS OF β-ADRENORECEPTORS GENES POLYMORPHISMS WITH THE COURSE OF HEART FAILURE AND WITH THE LOW TRIIODOTHYRONINE SYNDROME (LITERATURE REVIEW AND OWN OBSERVATIONS)E
- Author
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Pyvovar, Sergiy, primary, Rudyk, Iurii, additional, and Shcherban, Tetiana, additional
- Published
- 2023
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4. Promising Role of Vascular Endothelial Growth Factor-A in Risk Stratification after PCI
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V. Petyunina, Olga, primary, P. Kopytsya, Mykola, additional, S. Rudyk, Iurii, additional, and S. Isayeva, Ganna, additional
- Published
- 2019
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5. Association between ultrasonographic parameters, clinical and biochemical indicators and results of surveys in patients with heart failure with moderately reduced left ventricle fraction
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Rudyk, Iurii, primary, Babichev, Denys, additional, Medentseva, Olena, additional, and Gasanov, Iurii, additional
- Published
- 2022
- Full Text
- View/download PDF
6. Influence of Diabetes and M235Tangiotensinogen Gene Polymorphism on Lipid Metabolism in Patients with Heart Failure
- Author
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Medentseva, Olena, Rudyk, Iurii, Gasanov, Iurii, and Babichev, Denys
- Published
- 2021
- Full Text
- View/download PDF
7. Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: Observational study using prospectively collected registry data
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Pope, Marita Knudsen, Hall, Trygve S, Schirripa, Valentina, Radic, Petra, Virdone, Saverio, Pieper, Karen S, Le Heuzey, Jean-Yves, Jansky, Petr, Fitzmaurice, David A, Cappato, Riccardo, Atar, Dan, Camm, A John, Kakkar, Ajay K, Bassand, Jean-Pierre, Fox, Keith A A, Gersh, Bernard J, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G, Misselwitz, Frank, Turpie, Alexander G G, van Eickels, Martin, Verheugt, Freek W A, Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J, Eikelboom, John, Corbalan, Ramon, Jing, Zhi-Cheng, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Darius, Harald, Keltai, Matyas, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Hu, Dayi, Chen, Kangning, Zhao, Yusheng, Zhang, Huaiqin, Chen, Jiyan, Cao, Shiping, Wang, Daowen, Yang, Yuejin, Li, Weihua, Li, Hui, Yin, Yuehui, Tao, Guizhou, Yang, Ping, Chen, Yingmin, He, Shenghu, Wang, Yong, Fu, Guosheng, Li, Xin, Wu, Tongguo, Cheng, Xiaoshu, Yan, Xiaowei, Zhao, Ruiping, Chen, Moshui, Xiong, Longgen, Chen, Ping, Jiao, Yang, Guo, Ying, Xue, Li, Yang, Zhiming, Jadhavm, Praveen, Sarma, Raghava, Kulkarni, Govind, Chandwani, Prakash, Pothiwala, Rasesh Atulbhai, Purayil, Mohanan Padinhare, Chawla, Kamaldeep, Kothiwale, Veerappa Annasaheb, Raghuraman, Bagirath, Vijan, Vinod Madan, Sawhney, Jitendra, Bantwal, Ganapathi, Khan, Aziz, Meena, Ramdhan, Chopada, Manojkumar, Abraham, Sunitha, Bisne, Vikas, Vijayaraghavan, Govindan, Roy, Debabrata, Durgaprasad, Rajashekhar, Shankar, A G Ravi, Kumar, Sunil, Jain, Dinesh, Bhargava, Kartikeya, Kumar, Vinay, Nagamalesh, Udigala Madappa, Rajput, Rajeeve Kumar, 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Guerrero, Rodolfo Andres Ahuad, Di Paola, Leonel Adalberto, Dran, Ricardo Dario, Egido, Javier, Fosco, Matias Jose, Sinisi, Victor Alfredo, Cartasegna, Luis Rodolfo, Vilamajo, Oscar Gomez, Ramos, Jose Luis, Sassone, Sonia, Zapata, Gerardo, Conde, Diego, Giacomi, Guillermo, Fernandez, Alberto Alfredo, Berli, Mario Alberto, Ferroni, Fabian, Filho, Dário Celestino Sobral, Jaber, Jefferson, Armaganijan, Luciana Vidal, Costantini, Costantino Roberto Frack, Steffens, André, de Souzaem, Weimar Kunz Sebba Barroso, de Souza Neto, João David, Ribeiro, José Márcio, Teixeira, Marcelo Silveira, Rossi, Paulo, Pires, Leonardo, Moreira, Daniel, Jorge, José Carlos Moura, Filho, Adalberto Menezes Lorga, Bodanese, Luiz, Montera, Marcelo Westerlund, Del Carlo, Carlos Henrique, Saad, Jamil Abdalla, Alves da Costa, Fernando Augusto, Lopes, Renato, de Araújo, Gilson Roberto, Manenti, Euler Roberto, Saraiva, Jose Francisco Kerr, Braga, João Carlos Ferreira, Negri, Alexandre, Moncada, Carlos, Precoma, Dalton, Roquette, Fernando, Reis, Gilmar, Ramos Filho, Roberto Álvaro, Figueiredo, Estêvão Lanna, Botelho, Roberto Vieira, da Fontoura Tavares, Cláudio Munhoz, Finimundi, Helius Carlos, Kochi, Adriano, França, César Cássio Broilo, Alban, Fábio, Rosito, Guido Bernardo Aranha, Junior, João Batista de Moura Xavier Moraes, Tumelero, Rogério Tadeu, Maia, Lilia, de Almeida, Roberto Simões, do Carmo Borges, Ney Carter, Gomes Ferreira, Luís Gustavo, Corbalán, Ramón, Fernandez, Benjamin Aleck Joseh Stockins, Montecinos, Humberto, Lanas, Fernando, Gómez, Martín Larico, Astudillo, Carlos, Conejeros, Carlos, Cuevas, Patricio Marin, Forero, Alejandro, Gutiérrez, Claudio Bugueño, Aguilar, Juan, Cardenas, Sergio Potthoff, Eggers, German, Houzvic, Cesar, Rey, Carlos, Arriagada, Germán, Vilches, Gustavo Charme, Illescas Diaz, Jesus Jaime, Cantu, Raul Leal, Ramos Zavala, Maria Guadalupe, Jardines, Ricardo Cabrera, Zavaleta, Nilda Espinola, Rosas, Enrique Lopez, Llamas Esperón, Guillermo Antonio, Pozas, Gerardo, Muñoz, Ernesto Cardona, Hernandez, Norberto Matadamas, Rendon, Adolfo Leyva, Hernandez, Norberto Garcia, de los Rios Ibarra, Manuel, Carrillo, Luis Ramon Virgen, Villezca, David Lopez, Herrera, Carlos Hernandez, Lopez Prieto, Juan Jose, Rodriguez, Rodolfo Gaona, Espinosa, Efrain Villeda, Martinez, David Flores, Barcena, Jose Velasco, Fierro, Omar Fierro, Briones, Ignacio Rodriguez, Leiva Pons, Jose Luis, Lopez, Humberto Alvarez, Ruiz, Rafael Olvera, Brito, Carlos Gerardo Cantu, Valenzuela, Eduardo Julian Jose Roberto Chuquiure, Sanchez, Roxana Reyes, Bazzoni Ruiz, Alberto Esteban, Lopez Ruiz, Oscar Martin, Nava, Roberto Arriaga, Morales Cerda, Jesus David, Campos, Pedro Fajardo, Gonzalez, Mario Benavides, Lenz, Kurt, Hagn, Claus, Foechterle, Johannes, Drexel, Heinz, Huber, Kurt, Podczeck-Schweighofer, Andrea, Winkler, Michael, Schneeweiss, Bruno, Gegenhuber, Alfons, Lang, Wilfried, Eichinger-Hasenauer, Sabine, Kaserer, Peter, Sykora, Josef, Rasch, Heribert, Strohmer, Bernhard, Capiau, Luc, Vervoort, Geert, Wollaert, Bart, Hollanders, Geert, Vercammen, Jan, Faes, Dirk, Balthazar, Yohan, Delforge, Marc, Xhaet, Olivier, Striekwold, Harry, Thoeng, John, Hermans, Kurt, Mairesse, Georges, Anné, Wim, Blankoff, Ivan, Beutels, Michel, Verstraete, Stefan, Vandergoten, Peter, Purnode, Philippe, Godart, Pascal, Boussy, Tim, Desfontaines, Philippe, Heyse, Alex, Voet, Joeri, De Wolf, Axel, Zidkova, Eva, Spacek, Rudolf, Machova, Vilma, Ludka, Ondrej, Olsr, Josef, Kotik, Lubos, Racz, Blazej, Ferkl, Richard, Hubac, Jan, Kotik, Ilja, Monhart, Zdenek, Burianova, Hana, Jerabek, Ondrej, Pisova, Jana, Petrova, Iveta, Dedek, Vratislav, Honkova, Michaela, Podrazil, Petr, Reichert, Petr, Spinar, Jindrich, Novak, Miroslav, Durdil, Vaclav, Plocova, Katarina, Lastuvka, Jiri, Nielsen, Jørn, Husted, Steen, Dominguez, Helena, Hintze, Ulrik, Rasmussen, Søren, Sygehus, Næstved, Bremmelgaard, Arne, Markenvard, John, Børger, Jan, Solgaard, Jorgen, Eriksen, Ebbe, Løkkegaard, Thomas, Bruun, Michael, Mertz, Jacob, Schou, Morten, Olsen, Michael, Airaksinen, K E Juhani, Paganelli, Franck, Ohayon, Joël, Casassus, Frédéric, Galinier, Michel, Gottwalles, Yannick, Loiselet, Philippe, Muller, Jean-Joseph, Koujan, Mohamed Bassel, Marquand, André, Destrac, Sylvain, Piot, Olivier, Delarche, Nicolas, Cebron, Jean-Pierre, Guenoun, Maxime, Guedj-Meynier, Dominique, Lokesh, A G, Zuber, Mathieu, Amarenco, Pierre, Ellie, Emmanuel, Kadouch, James, Fournier, Pierre-Yves, Huberman, Jean-Pierre, Lemaire, Nestor, Rodier, Gilles, Vandamme, Xavier, Sibon, Igor, Neau, Jean-Philippe, Mahagne, Marie Hélène, Mielot, Antoine, Bonnefoy, Marc, Churet, Jean-Baptiste, Navarre, Vincent, Sellem, Frederic, Monniot, Gilles, Boyes, Jean-Paul, Doucet, Bernard, Martelet, Michel, Obadia, Désiré, Crousillat, Bernard, Mouallem, Joseph, Bearez, Etienne, Brugnaux, Jean Philippe, Fedorowsky, Alain, Nazeyrollas, Pierre, Berneau, Jean-Baptiste, Chemin, Frédéric, Schellong, Sebastien, Koeniger, Georg, Kopf, Andreas, Gerbaulet, Uwe, Kellner, Bernd-Thomas, Schaefer, Thomas, Purr, Jan, Eißfeller, Enno, Zauzig, Heinz-Dieter, Riegel, Peter, Axthelm, Christoph, Heinz, Gerd-Ulrich, Menke, Holger, Pustelnik, Andreas, Zutz, Stefan, Eder, Wolfgang, Rehling, Guenter, Glatzel, Dirk, Ludwig, Norbert, Sandow, Petra, Wiswedel, Henning, Wildenauer, Cosmas, Schoen, Steffen, Schwarz, Toralf, Babyesiza, Adyeri, Kropp, Maximilian, Zimny, Hans-Hermann, Kahl, Friedhelm, Caspar, Andreas, Omankowsky, Sabine, Laessig, Torsten, Hartmann, Hermann-Josef, Lehmann, Gunter, Bindig, Hans-Walter, Hergdt, Gunter, Reimer, Dietrich, Hauk, Joachim, Michel, Holger, Dres, Praxis, Erdle, Werner, Dorsch, Wilfried, Dshabrailov, Janna, Rapp, Karl-Albrecht, Vormann, Reinhold, Mueller, Thomas, Mayer, Peter, Horstmeier, Uwe, Eissing, Volker, Hey, Heinz, Leuchtgens, Heinz, Lilienweiss, Volker, Mueller, Heiner, Schubert, Christian, Lauer, Herrmann, Buchner, Thomas, Brauer, Gunter, Kamin, Susanne, Mueller, Karsten, Baumbach, Sylvia, Abdel-Qader, Muwafeg, Ebert, Hans-Holger, Schwencke, Carsten, Bernhardt, Peter, Karolyi, Laszlo, Sievers, Britta, Haverkamp, Wilhelm, Roehnisch, Jens-Uwe, Vertes, Andras, Szantai, Gabor, Matoltsy, Andras, Kanakaridisz, Nikosz, Boda, Zoltan, Kis, Erno, Gaszner, Balazs, Juhasz, Ferenc, Juhasz, Gizella, Kancz, Sandor, Laszlo, Zoltan, May, Zsolt, Merkely, Bela, Noori, Ebrahim, Habon, Tamas, Polgar, Peter, Szalai, Gabriella, Vangel, Sandor, Nagy, Andras, Engelthaler, Gabriella, Ferenczi, Judit, Egyutt, Mihaly, Martini, Giuliana, Cristina, Leone Maria, Tiraferri, Eros, Santoro, Rita, Testa, Sophie, Di Minno, Giovanni, Moia, Marco, Caimi, Teresa Maria, Tessitori, Maria, Cappelli, Roberto, Poli, Daniela, Quintavalla, Roberto, Cosmi, Franco, Fanelli, Raffaele, Oriana, Vincenzo, Reggio, Raffaele, Santi, Roberto, Pancaldi, Leonardo, De Cristofaro, Raimondo, Guazzaloca, Giuliana, De Blasio, Angelo, Uriate, Jorge Salerno, Lillo, Flavia, Pogliani, Enrico Maria, Bilo, Grzegorz, Accogli, Michele, Mariani, Antonio, Feola, Mauro, Raisaro, Arturo, Fattore, Luciano, Mauric, Andrea, Germini, Fabrizio, Tedeschi, Luca, Settimi, Maria, Nicoli, Sergio, Ricciarini, Paolo, Argena, Antonio, Ronchini, Paolo, Bulla, Claudio, Tradati, Filippo, Volpe, Massimo, D’Avino, Maria, Bongiorni, Maria Grazia, Severi, Silva, Capucci, Alessandro, Lodigiani, Corrado, Salomone, Enrico, Serviddio, Gaetano, Tondo, Claudio, Golino, Paolo, Mazzone, Carmine, Iacopino, Saverio, ten Cate, Hugo, Ruiter, J H, Lucassen, Andreas, Adriaansen, Henk, Bongaerts, Maarten, Pieterse, Mathijs, van Guldener, Coen, Herrman, Johannes, Nierop, S H K P R, Hoogslag, Pieter, Hermans, Walter, Groenemeijer, B E, Terpstra, W, Buiks, Cees, Boersma, L V A, Berge, Eivind, Sirnes, Per Anton, Gjertsen, Erik, Hole, Torstein, Erga, Knut, Hallaråker, Arne, Skjelvan, Gunnar, Østrem, Anders, Ghezai, Beraki, Svilaas, Arne, Christersson, Peter, Øien, Torbjørn, Henrichsen, Svein Høegh, Otterstad, Jan Erik, Berg-Johansen, Jan, Gieroba, Andrzej, Biedrzycka, Malgorzata, Ogorek, Michal, Wozakowska-Kaplon, Beata, Loboz-Grudzien, Krystyna, Supinski, Wieslaw, Kuzniar, Jerzy, Zaluska, Roman, Hiczkiewicz, Jaroslaw, Swiatkowska-Byczynska, Lucyna, Kucharski, Lech, Gruchala, Marcin, Minc, Piotr, Olszewski, Maciej, Kania, Grzegorz, Krzciuk, Malgorzata, Lajkowski, Zbigniew, Ostrowska-Pomian, Bozenna, Lewczuk, Jerzy, Zinka, Elzbieta, Karczmarczyk, Agnieszka, Chmielnicka-Pruszczynska, Malgorzata, Wozniak-Skowerska, Iwona, Opolski, Grzegorz, Bronisz, Marek, Ogorek, Marcin, Glanowska, Grazyna, Ruszkowski, Piotr, Skonieczny, Grzegorz, Sciborski, Ryszard, Okopien, Boguslaw, Kukla, Piotr, Galbas, Krzysztof, Cymerman, Krzysztof, Jurowiecki, Jaroslaw, Miekus, Pawel, Myszka, Waldemar, Mazur, Stanislaw, Lysek, Roman, Baszak, Jacek, Rusicka-Piekarz, Teresa, Raczak, Grzegorz, Domanska, Ewa, Nessler, Jadwiga, Lesnik, Jozef, Eltishcheva, Vera, Libis, Roman, Kamalov, Gadel, Belenky, Dmitry, Egorova, Liudmila, Khokhlov, Alexander, Yakupov, Eduard, Zateyshchikov, Dmitry, Barbarash, Olga, Miller, Olga, Mazur, Evgeniy, Zrazhevskiy, Konstantin, Novikova, Tatyana, Moiseeva, Yulia, Polkanova, Elena, Sobolev, Konstantin, Rossovskaya, Maria, Shapovalova, Yulia, Kolesnikova, Alla, Nikolaev, Konstantin, Zemlianskaia, Oksana, Zateyshchikova, Anna, Kostenko, Victor, Popov, Sergey, Poltavskaya, Maria, Edin, Anton, Aleksandrova, Elena, Drapkina, Oksana, Vishnevsky, Alexander, Nagibovich, Oleg, Chizhov, Petr, Rachkova, Svetlana, Sergeev, Mikhail, Kurylo, Borys, Ushakov, Alexey, Vinolas, Xavier, Garcia, Pere Alvarez, Lopez Fernandez, Maria Fernanda, Sanchez, Luis Tercedor, Iparraguirre, Salvador Tranche, Monserrat, Pere Toran, Contreras, Emilio Marquez, Rafecas, Jordi Isart, Carrasco, Juan Motero, Pavia, Pablo Garcia, Pajuelo, Casimiro Gomez, Rincon Diaz, Luis Miguel, Iglesias Alonso, Luis Fernando, Ruiz, Angel Grande, Klein, Jordi Merce, Gonzalez Juanatey, Jose Ramon, Collado, Ines Monte, Piquero, Herminia Palacin, Cuixart, Carles Brotons, Escobar, Esther Fernandez, Bayo i Llibre, Joan, Vicente, Cecilia Corros, Gutierrez, Manuel Vida, Gonzalo, Francisco Epelde, Almeida Fernandez, Carlos Alexandre, Navarro, Encarnacion Martinez, Alia, Juan Jose Montero, Gonzalez, Maria Barreda, Oliva, Maria Angels Moleiro, Sanmartin, Jose Iglesias, Gonzalez, Mercedes Jimenez, Alvarez, Maria del Mar Rodriguez, Melenchon, Juan Herreros, Vera, Tomas Ripoll, Navarro, Manuel Jimenez, Caamano, Maria Vazquez, Arcocha Torres, Maria Fe, Gomez, Gonzalo Marcos, Romo, Andres Iniguez, Prieto Diaz, Miguel Angel, Rosenqvist, Mårten, Wirdby, Alexander, Lindén, Jan, Henriksson, Kerstin, Elmersson, Micael, Egilsson, Arnor, Börjesson, Ulf, Svärd, Gunnar, Liu, Bo, Lindh, Anders, Olsson, Lars-Bertil, Gustavsson, Mikael, Andersson, Lars, Benson, Lars, Bothin, Claes, Hajimirsadeghi, Ali, Martinsson, Björn, Ericsson, Marianne, Ohlsson, Åke, Lindvall, Håkan, Svensson, Peter, Thörne, Katarina, Händel, Hans, Platonov, Pyotr, Bernsten, Fredrik, Timberg, Ingar, Crisby, Milita, Karlsson, Jan-Erik, Andersson, Agneta, Malmqvist, Lennart, Engdahl, Johan, Thulin, Jörgen, Hot-Bjelak, Aida, Jensen, Steen, Stalby, Per, Debrunner, Johann, Beer, Juerg H, Shah, Dipen, Rudyk, Iurii, Tseluyko, Vira, Karpenko, Oleksandr, Zhurba, Svitlana, Kraiz, Igor, Parkhomenko, Oleksandr, Kupnovytska, Iryna, Seredyuk, Nestor, Mostovoy, Yuriy, Ushakov, Oleksiy, Koval, Olena, Kovalskiy, Igor, Svyshchenko, Yevgeniya, Sychov, Oleg, Stanislavchuk, Mykola, Yagensky, Andriy, Tykhonova, Susanna, Fushtey, Ivan, Murdoch, Will, Chauhan, Naresh, Goodwin, Daryl, Lumley, Louise, Patel, Ramila, Saunders, Philip, Wong, Bennett, Cameron, Alex, Patel, Niranjan, Jhittay, P, Ross, Andrew, Kainth, M S, Ladha, Karim, Douglas, Kevin, Pickavance, Gill, McDonnell, Joanna, Handscombe, Laura, Gooding, Trevor, Wagner, Helga, Bradshaw, Colin, Bromham, Catherine, Jones, Kevin, Suryani, Shoeb, Coates, Richard, Sarai, Bhupinder, Willcock, W, Sircar, S, Cairns, John, Gilliand, A, Bilas, Roman, Strieder, E, Hutchinson, Peter, Wakeman, Anne, Stokes, Michael, Kirby, Graham, Vishwanathan, Bhaskhar, Bird, Nigel, Evans, Paul, Clark, M, Bisatt, John, Litchfield, Jennifer, Fisher, E, Fooks, Tim, Kelsall, Richard, Paul, Neil, Alborough, Elizabeth, Aziz, Michael, Ramesh, C, Wilson, Pete, Franklin, Simon, Fairhead, Sue, Thompson, Julian, Chowan, Hasan, Taylor, Gary, Tragen, Dawn, Parfitt, Matt, Seamark, Claire, Paul, Carolyn, Richardson, Mark, Jefferies, Angus, Sharp, Helen, Jones, Hywel, Giles, Claire, Bramley, Matthew, Williams, Philip, Aldegather, Jehad, Wetherell, Simon, Lumb, William, Evans, Phil, Scouller, Frances, Macey, Neil, Rogers, Stephen, Stipp, Yvette, West, Richard, Pinney, Philip, Wadeson, Paul, Matthews, John, Pandya, Preeti, Gallagher, Andrew, Railton, T, Davies, Emyr, McClure, Jonathan, Jacobs, Marc, Hutton, Claire, Thompson, R, Sinha, Bijoy, Butter, Keith, Barrow, Susan, Little, Helen, Russell, David, Choudhary, Ulka, Haq, Ikram, Ainsworth, Paul, Jones, Claire, Weeks, Phil, Eden, Jane, Gibbons, Lisa, Glencross, Janet, MacLeod, Alison, Poland, K, Mulolland, Conor, Warke, A, Conn, Paul, Burns, D, Smith, R, Kamath, R, Webster, Jonathan, Hodgins, Ian, Vercoe, Stephen, Roome, Paul, Pinnock, Hilary, Patel, Jayesh, Ali, Amar, Hart, Nigel, Davies, Richard, De-Sousa, Nigel, Neden, Catherine, Danielsen, Mark, Sharma, Purnima, Galloway, Sophia, Hawkins, Charlotte, Oliver, Raife, Aylward, Martin, Pattni, Mira, Irvine, Gordon, Ahmad, Shahid, Rothwell, Catherine, Choudhary, Fiaz, Khalaque, Sabrina, Short, Stephanie, Peters, Sharon, Coulson, Warwick, Roberts, Neil, Butler, Amy, Coates, Steven, Ward, Ben, Jackson, Daniel, Walton, Steve, Shepherd, Diane, Wong, Toh, Boon, Mark, Deacon, Melanie, Cornelius, David, Davies, Sarah, Frankel, Ben, Hargreaves, Nick, Choi, Henry, Sumner, Jon, Myhill, Tim, Estifanos, Salah, Geatch, Diane, Wilkinson, Justin, Veale, Richard, Forshaw, Karen, Hirst, Rob, Zaman, Kashif, Liley, Catherine, Wastling, Rebecca, McEleny, Paul, Beattie, Andre, Cooke, Philip, Wong, Mike, Pugsley, Mark, Dooldeniya, Chaminda, Rogers, Greg, Bennett, James, Jacobs, Polly, Muvva, Rajesh, Adam, Matthew, Fox, Robin, Thomas, Nicolas, Cartwright, Simon, Reed, Rory, Randfield, Simon, A’Court, Christine, Flynn, Ann, Halpin, Andrew, Dobson, Simon, Lomax, Louise, Nadaph, Minnal, Munro, Iain, Goram, Jane, Stoddart, Helen, Simmons, Phil, Shewring, John, Bowen-Simpkins, Emma, Rickenbach, Mark, Blenkhorn, Adam, Singh, Bhuwanendu, Astridge, Penny, van Gaal, William, Abhayaratna, Walter, Thomson, Philip, Lehman, Ron, Kilian, Jens, Coulshed, David, Catanchin, Andrei, Colquhoun, David, Kiat, Hosen, Eccleston, David, French, John, Ayres, Bronte, Blombery, Peter, Phan, Thanh, Rogers, James, O’Donnell, David, Bae, Sang Cheol, Carroll, Patrick, Starmer, Greg, Arstall, Margaret, Binnekamp, Maurits, Lee, Astin, Luton, Robert, Gupta, Milan, Pandey, Amritanshu Shekhar, Cheung, Stephen, Leader, Rolland, Beaudry, Philippe, Ayala-Paredes, Félix, Berlingieri, Joseph, Heath, John, Poirier, Germain, du Preez, Miranda, Schweitzer, Bradley, Nadeau, Reginald, Dhillon, Ripple, Hruczkowski, Tomasz, Lavoie, Andrea, Parkash, Ratika, Cha, James, Coutu, Benoit, MacDonald, Paul, Ramjattan, Brian, Bonet, Jorge, Vizel, Saul, Angaran, Paul, Fikry, Sameh, Mowafy, Ahmed, Katta, Azza, Tawfik, Mazen, Nawar, Moustafa, Sobhy, Mohamed, Abou Seif, Seif Kamal, Khairy, Tarek, El-Aziz, Ahmed Abd, Taha, Nasser, Reda, Ashraf, Elbahry, Atef, Setiha, Mohamed, El Din, Mohamed Gamal, Elkhadem, Magdi, El-Etreby, Adel, Kettles, David, Bayat, Junaid, Siebert, Heidi, Horak, Adrian, Kelfkens, Ynez, Garda, Riaz, Pillay, Thayabran, Guerra, Michele, van Zyl, Louis, Theron, Hendrik, Murray, Andrew, Louw, Rikus, Greyling, Deon, Mntla, Pindile, Ismail, Siddique, Ahmed, Fayzal, Engelbrecht, Johannes, Maharajh, Shambu, Oosthuysen, Wessel, Loghdey, Rehana, Ueckermann, Veronica, Al Naeemi, Abdullah, Yousef, Ghazi, Bazargani, Nooshin, AlOmairi, Munther, Maruthanayagam, Rajan, Singh, Rupesh, Naguib, Ahmed, Ibrahim, Mohamed, Agrawal, Amrish, Nathani, Mukesh, Esheiba, Ehab M, Wassef, Adel, Gupta, Rajeev, Cox, Michael, Beach, Scott, Duffy, Peter, Falkowski, Stephen, Ferrick, Kevin, Franco, Miguel, Kutayli, W Michael, Quick, Annette, Sharma, Niraj, Wilson, Vance, Miller, Stephen, Alberts, Mark, Blumberg, Edwin, Canosa, Roddy, Gutowski, Ted, Ison, Rodney, Garcia, Jorge, Mullen, Paul, Noveck, Howard, Rama, Pamela, Reddy, Rajneesh, Williams, Marcus, Nishijima, Daniel, Ferdinand, Keith, Haque, Ihsan, Mendelson, Robert, Pitta, Sridevi, Theodoro, Daniel, Treasure, Charles, Moustafa, Moustafa, Cader, Cas, Pharr, Walter, Oropallo, Alisha, Platt, George, Gujral, Jaspal, Welker, James, and Koura, Firas
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Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Electric Countershock ,Therapeutics ,Cardioversion ,Lower risk ,Cause of Death ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Prospective Studies ,Registries ,Propensity Score ,Stroke ,Aged ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Research ,Anticoagulant ,Hazard ratio ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Propensity score matching ,Cardiology ,Female ,business ,RC - Abstract
OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. CONCLUSION In this large dataset of patients with recent onset non-valvular atrial fibrillation, a small proportion were treated with cardioversion. Direct current cardioversion was performed twice as often as pharmacological cardioversion, and there appeared to be no major difference in outcome events for these two cardioversion modalities. For the overall cardioversion group, after adjustments for confounders, a significantly lower risk of mortality was found in patients who received early cardioversion compared with those who did not receive early cardioversion. STUDY REGISTRATION ClinicalTrials.gov NCT01090362.
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- 2021
8. MANAGEMENT OF PATIENTS WITH HEART FAILURE AND COVID-19
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Rudyk, Iurii, primary, Medentseva, Оlena, additional, Babichev, Denys, additional, and Kravchenko, Iryna, additional
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- 2021
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9. Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
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Teerlink, John R., Diaz, Rafael, Felker, G. Michael, McMurray, John J.V., Metra, Marco, Solomon, Scott D., Adams, Kirkwood F., Anand, Inder, Arias‐Mendoza, Alexandra, Biering‐Sørensen, Tor, Böhm, Michael, Bonderman, Diana, Cleland, John G.F., Corbalan, Ramon, Crespo‐Leiro, Maria G., Dahlström, Ulf, Echeverria Correa, Luis E., Fang, James C., Filippatos, Gerasimos, Fonseca, Cândida, Goncalvesova, Eva, Goudev, Assen R., Howlett, Jonathan G., Lanfear, David E., Lund, Mayanna, Macdonald, Peter, Mareev, Vyacheslav, Momomura, Shin‐ichi, O'Meara, Eileen, Parkhomenko, Alexander, Ponikowski, Piotr, Ramires, Felix J. A., Serpytis, Pranas, Sliwa, Karen, Spinar, Jindrich, Suter, Thomas M., Tomcsanyi, Janos, Vandekerckhove, Hans, Vinereanu, Dragos, Voors, Adriaan A., Yilmaz, Mehmet B., Zannad, Faiez, Sharpsten, Lucie, Legg, Jason C., Abbasi, Siddique A., Varin, Claire, Malik, Fady I., Kurtz, Christopher E., Besada, Diego Alejandro, Majul, Claudio Rodolfo, Bruno, Marco Raul Litvak, Sassone, Sonia, Avaca, Horacio Alberto, Rasmussen, Mariela, Aiub, Jorge Roberto, Hominal, Miguel Angel, Perna, Eduardo, Duran, Ruben Omar Garcia, Schiavi, Lilia, Marquez, Lilia Luz Lobo, Vilamajo, Oscar Alberto Gomez, Mackinnon, Ignacio, Fuente, Ricardo Alfonso Leon, Montana, Oscar Romano, Novaretto, Leonardo, Guerrero, Rodolfo Andres Ahuad, Brasca, Daniela Garcia, Prado, Aldo, Garrido, Marcelo Alejandro, Luquez, Hugo, Martinez, Diego Felipe, Nicolosi, Liliana, Parody, Maria Leonor, Zaidman, Cesar, Berra, Fernando Colombo, Ibañez, Julio, Zapata, Gerardo, Caccavo, Alberto, Colque, Roberto, Diez, Mirta, Poy, Carlos, Salomone, Oscar Alejandro, Vogel, Daniel, Bordonava, Anselmo Paulino, Fernandez, Alberto, French, John, Atherton, John, Hamilton, Andrew, Begg, Alistair, Abhayaratna, Walter, Judkins, Christopher, De Pasquale, Carmine, McKenzie, Scott, Amerena, John, Szto, Gregory, Kearney, Leighton, Zimmet, Hendrik, Sverdlov, Aaron, Beltrame, John, Korczyk, Dariusz, Sindone, Andrew, Moertl, Deddo, Huber, Kurt, Huelsmann, Martin, Ablasser, Klemens, Ebner, Christian, Siostrzonek, Peter, Drexel, Heinz, Poelzl, Gerhard, Dujardin, Karl, Dupont, Matthias, Buysschaert, Ian, Lancellotti, Patrizio, Droogne, Walter, Chouchane, Iman, Silveira, Fabio, Rassi, Salvador, Reis, Gilmar, Filho, Pedro Pimentel, Simoes, Marcus Vinicius, Braga, Joao Carlos, Giorgeto, Flavio Eduardo, Ferraz, Almir, Jaeger, Cristiano Pederneiras, Saraiva, Jose Francisco, Tognon, Alexandre, Cardoso, Juliano, Greco, Oswaldo, Paiva, Maria Sanali, Paolino, Bruno, Filho, Otavio Coelho, Maia, Lilia Nigro, Silva, Rodrigo, Canesin, Manoel, Rossi, Paulo Roberto Ferreira, Fortes, Jose Augusto Ribas, Cerci, Rodrigo Julio, Manenti, Euler Roberto Fernandes, Leaes, Paulo Ernesto, Silva Neto, Luis Beck, Souza, Weimar Kunz Barroso, Bacal, Fernando, Chaves, Renato, Ramires, Felix, Vidotti, Maria Helena, Barros e Silva, Pedro Gabriel Melo, Piegas, Leopoldo Soares, Todorov, Georgi, Tzekova, Maria, Goudev, Assen, Mincheva, Valentina, Vasilev, Ivaylo, Tisheva‐ Gospodinova, Snezhanka, Petrov, Ivo, Postadzhiyan, Arman, Velikov, Chavdar, Dimov, Bojidar, Constance, Christian, Phaneuf, Denis‐Carl, Mielniczuk, Lisa, Pandey, A Shekhar, Senaratne, Manohara, Zieroth, Shelley, Savard, Daniel, Stewart, Robert, Huynh, Thao, Giannetti, Nadia, Moe, Gordon, Bourgeois, Ronald, Ezekowitz, Justin, Hartleib, Michael, Sussex, Bruce, Babapulle, Mohan, Chehayeb, Raja, Gaudet, Daniel, McKelvie, Robert, Nguyen, Viviane, Roth, Sherryn, Gupta, Milan, Pesant, Yves, Rupka, Dennis, Bhargava, Rakesh, Costa‐Vitali, Atilio, Proulx, Guy, Vega, Mario, Potthoff, Sergio, Cid, Maria Cristina Schnettler, Sepulveda, Alex Mauricio Villablanca, Zanetti, Fernando Tomas Lanas, Gajardo, Victor Areli Saavedra, Kindel, Carlos Conejeros, Jofre, Christian Paolo Pincetti, Segarra, Jorge Leonardo Cobos, Venegas, Manuel Eduardo Rodriguez, Hidalgo, Mario Yanez, Jalaf, Margarita Gertrudis Vejar, Li, Weimin, Zhang, Jinguo, Fu, Xin, Zhang, Xuelian, Li, Dongye, Wang, Zhifang, Qu, Yanling, Zheng, Zhe, Tang, Huifang, Yang, Ping, Zhang, Yuhui, Zheng, Yang, Mi, Yafei, Huang, He, Bu, Peili, Chen, Guoqin, Chen, Jiyan, Han, Yajun, Li, Zhangquan, Ma, Shumei, Yang, Xuming, Yuan, Zuyi, Dong, Yugang, Li, Zhaoping, Mahemuti, Ailiman, Niu, Wentang, Yang, Zhenyu, Zhang, Yuqing, Sun, Yuemin, Wu, Weiheng, Liu, Feng, Yan, Jing, Li, Yinjun, Wang, Yi, Zhang, Shouyan, Zhou, Changyong, Cui, Hanbin, Li, Jianjun, Li, Tianfa, Han, Qinghua, Wei, Yu, Correa, Luis Eduardo Echeverria, Mendoza, Jose Luis Accini, Jattin, Fernando Manzur, Osorio, Wilder Castaño, Luengas, Carlos Alberto, Arroyo, Julian Alonso Coronel, Corredor, Miguel Alfredo Moncada, Giraldo, Clara Ines Saldarriaga, Lopez, Rodrigo Botero, Salazar, Dora Ines Molina, Triana, Miguel Urina, Lopez, Luis Horacio Atehortua, Rojas, Pastor Olaya, Pelaez, Sebastian Velez, Pareja, Monica Lopez, Bonfanti, Alberto Cadena, Polasek, Rostislav, Monhart, Zdenek, Sochor, Karel, Motovska, Zuzana, Belohlavek, Jan, Busak, Ladislav, Krupicka, Jiri, Tyl, Petr, Jerabek, Ondrej, Podpera, Ivo, Skrobakova, Janka, Peterka, Karel, Spacek, Rudolf, Cech, Vladimir, Kellnerova, Ivana, Nechvatal, Libor, Pozdisek, Zbynek, Houra, Marek, Kryza, Radim, Machova, Vilma, Cepelak, Michal, Stepek, David, Zeman, Kamil, Klimsa, Zdenek, Koleckar, Pavel, Schee, Alexandr, Spinarova, Lenka, Coufal, Zdenek, Jeppesen, Jorgen, Vraa, Soren, Wiggers, Henrik, Nyvad, Ole, Nielsen, Tonny, Kaiser‐Nielsen, Peter, Videbaek, Lars, Galinier, Michel, Lefebvre, Jean‐Marie, Tartiere, Jean‐Michel, De Geeter, Guillaume, Roubille, Francois, Ricci, Jean Etienne, Salvat, Muriel, Gueffet, Jean‐Pierre, Decoulx, Eric, Berdague, Philippe, Jondeau, Guillaume, Ovize, Michel, Groote, Pascal De, Donal, Erwan, Isnard, Richard, Sabatier, Rémi, Trochu, Jean Noel, Damy, Thibaud, Georges, Jean‐Louis, Rosamel, Yann, Picard, François, Aboyans, Victor, Laperche, Thierry, Mitrovic, Veselin, Taggeselle, Jens, Störk, Stefan, Ebelt, Henning, Genth‐Zotz, Sabine, Rassaf, Tienush, Duengen, Hans‐Dirk, Mittag, Marcus, Menck, Niels, Zeymer, Uwe, Haehling, Stephan, Boehm, Michael, Frankenstein, Lutz, Killat, Holger, Bourhaial, Hakima, Beug, Daniel, Horacek, Thomas, Pfister, Roman, Sandri, Marcus, Westenfeld, Ralf, Kadel, Christoph, Karvounis, Haralambos, Patsilinakos, Sotirios, Mantas, Ioannis, Karavidas, Apostolos, Giamouzis, Grigorios, Tsioufis, Konstantinos, Naka, Katerina, Tziakas, Dimitrios, Parissis, John, Styliadis, Ioannis, Barbetseas, Ioannis, Manolis, Athanasios, Kochiadakis, George, Herczeg, Bela, Nagy, Laszlo, Nyolczas, Noemi, Toth, Kalman, Merkely, Bela, Laszlo, Zoltan, Mark, Laszlo, Szakal, Imre, Papp, Andras, Bezzegh, Katalin, Lakatos, Ferenc, Hajko, Erik, Papp, Aniko, Forster, Tamas, Lupkovics, Geza, Mohacsi, Attila, Salamon, Csaba, Aradi, Daniel, Andreka, Peter, Szasz, Gyula, Zilahi, Zsolt, Kazinczy, Rita, Margonato, Alberto, Agostoni, Piergiuseppe, Fucili, Alessandro, Piovaccari, Giancarlo, Senni, Michele, Carluccio, Erberto, Bilato, Claudio, Frigerio, Maria, Indolfi, Ciro, Sinagra, Gianfranco, Brunetti, Natale Daniele, Perna, Gianpiero, Pini, Daniela, Volterrani, Maurizio, Leonardi, Sergio, Mortara, Andrea, Friz, Hernan Emilio Francisco Polo, Rossini, Roberta, Tocchetti, Carlo Gabriele, Vincenzi, Antonella, Cavallini, Claudio, Floresta, Agata Marina, Zaca, Valerio, Giudici, Vittorio, Villani, Giovanni Quinto, Higashino, Yorihiko, Oishi, Shogo, Wada, Atsuyuki, Fukuzawa, Shigeru, Onoue, Kenji, Koike, Akihiro, Koizumi, Tomomi, Masuda, Seigo, Mitsuo, Kazuhisa, Takahashi, Natsuki, Takenaka, Takashi, Tanabe, Jun, Watanabe, Naoki, Yoshida, Takeshi, Amano, Tetsuya, Ishikawa, Masahiro, Kida, Keisuke, Kubota, Toru, Nakamura, Kentaro, Sakamoto, Tomohiro, Shimomura, Mitsuhiro, Yuge, Masaru, Doi, Masayuki, Domae, Hiroshi, Ebato, Mio, Fujii, Kenshi, Fujiwara, Wakaya, Gohara, Seiichiro, Hata, Yoshiki, Kanda, Junji, Kitaoka, Hiroaki, Matsumoto, Takashi, Michishita, Ichiro, Miura, Shinichiro, Miyazaki, Tetsuro, Nakamura, Akihiro, Ogawa, Tomohiro, Okumura, Takahiro, Okumura, Yasuo, Sakai, Tetsuo, Sato, Yukihito, Shimizu, Wataru, Sugino, Hiroshi, Suzuki, Masahiro, Takagi, Atsutoshi, Takaishi, Hiroshi, Tanaka, Takahiro, Terasaki, Toshiro, Tsujimoto, Mitsuru, Ueda, Yasunori, Ujino, Keiji, Usui, Makoto, Yamamoto, Mitsutaka, Yoshikawa, Masaki, Ando, Kenji, Asakura, Masanori, Asano, Hiroshi, Fujii, Shigeru, Hara, Hisao, Inomata, Takayuki, Isshiki, Takaaki, Kadokami, Toshiaki, Kai, Hisashi, Kasai, Toshio, Kawamitsu, Katsunori, Kawasaki, Tomohiro, Koga, Tokushi, Komiyama, Nobuyuki, Maejima, Yasuhiro, Manita, Mamoru, Miyamoto, Nobuhide, Node, Koichi, Numaguchi, Kotaro, Sakata, Yasushi, Serikawa, Takeshi, Takama, Noriaki, Tatebe, Shunsuke, Ueno, Hideki, Hidaka, Takayuki, Hiroi, Shitoshi, Iseki, Harukazu, Ito, Hiroshi, Kajinami, Kouji, Kawakami, Hideo, Momiyama, Yukihiko, Mori, Masuki, Morita, Yukiko, Okishige, Kaoru, Sakagami, Satoru, Takeishi, Yasuchika, Terasawa, Akihiro, Utsu, Noriaki, Badariene, Jolita, Celutkiene, Jelena, Slapikas, Rimvydas, Jarasuniene, Dalia, Castillo, Armando Garcia, De los Rios Ibarra, Manuel Odin, Lopez, Gabriel Arturo Ramos, Llamas, Edmundo Alfredo Bayram, Esperon, Guillermo Antonio Llamas, Vazquez, Eduardo Salcido, Gonzalez, Ricardo Garcia, Leon, Jose Luis Arenas, Gonzalez, Salvador Leon, Mendoza, Maria Alexandra Arias, Rodriguez, Alicia Contreras, Machado, Gustavo Francisco Mendez, Salazar, Melchor Alpizar, Ruiz, Alberto Esteban Bazzoni, Flores, Ana Maria De Leon, Carrasco, Jose Alfredo Pagola, Araiza, Raul Reyes, Römer, Tjeerd, Remmen, Johannes, Van Eck, Jacob, Elvan, Arif, Smilde, Tom, Voors, Adriaan, Wal, Ruud, Schaap, Jeroen, Sluis, Aize, Linssen, Gerardus, Magro, Michael, Willems, Frank, Hal, John, Zwaan, Coenraad, Beelen, Driek, Boswijk, Dirk, Hermans, Walter, Van Kesteren, Henricus, Scott, Russell, Hart, Hamish, Lund, Marianne, Szczasny, Marcin, Blicharski, Tomasz, Kafara, Mariusz, Stankiewicz, Anna, Skonieczny, Grzegorz, Zabowka, Maciej, Kania, Grzegorz, Kopaczewski, Jerzy, Pawlowicz, Lidia, Spyra, Janusz, Wlodarczyk, Aleksander, Sciborski, Ryszard, Balsam, Pawel, Drozdz, Jaroslaw, Sobkowicz, Bozena, Konieczynska, Malgorzata, Lelonek, Malgorzata, Bednarkiewicz, Zbigniew, Trebacz, Jaroslaw, Jankowski, Piotr, Sidor, Mateusz, Berkowski, Piotr, Chmielak, Zbigniew, Lenartowska, Lucyna, Nessler, Jadwiga, Straburzynska‐Migaj, Ewa, Kalarus, Zbigniew, Kowalski, Robert, Kalecinska‐Krystkiewicz, Ewa, Gola, Zbigniew, Pijanowski, Zbigniew, Wozakowska‐Kaplon, Beata, Cymerman, Krzysztof, Rynkiewicz, Andrzej, Miekus, Pawel, Monteiro, Pedro, Sarmento, Pedro Morais, Almeida, Filipa, Duarte, Tatiana, Fonseca, Candida, Oliveira, Luis, Santos, Luis, Brito, Dulce, Stanciulescu, Gabriela, Spiridon, Marilena Renata, Militaru, Constantin, Podoleanu, Cristian Gheorghe, Zdrenghea, Dumitru, Popescu, Mircea Ioachim, Macarie, Cezar‐Eugen, Giuca, Alina, Mitu, Florin, Voicu, Olga‐Cristina, Dorobantu, Maria, Lighezan, Daniel, Stamate, Sorin, Bykov, Alexander, Kobalava, Zhanna, Zrazhevskiy, Konstantin, Semenova, Irina, Vishnevsky, Alexander, Shutemova, Elena, Tereschenko, Sergey, Shvarts, Yury, Barbarash, Olga, Lukyanov, Yury, Voevoda, Mikhail, Dovgolis, Svetlana, Dronov, Dmitry, Goloshchekin, Boris, Sitnikova, Maria, Ezhov, Marat, Tarasov, Nikolay, Kotelnikov, Mikhail, Kostenko, Viktor, Solovev, Oleg, Goncharov, Ivan, Myasnikov, Roman, Rafalskiy, Vladimir, Ryabov, Vyacheslav, Kosmacheva, Elena, Motylev, Igor, Nosov, Vladimir, Osipova, Irina, Salukhov, Vladimir, Belenkiy, Dmitriy, Bolshakova, Olga, Pimenov, Leonid, Shilkina, Nataliya, Kulibaba, Elena, Repin, Alexey, Timofeev, Alexander, Mitrokhin, Vladislav, Sherenkov, Alexander, Arbolishvili, Georgy, Antalik, Lubomir, Dzupina, Andrej, Fulop, Peter, Majercak, Ivan, Gonsorcik, Jozef, Vinanska, Daniela, Lenner, Egon, Lukacova, Jana, Margoczy, Roman, Smik, Rudolf, Stevlik, Jan, Uhliar, Rudolf, Burgess, Lesley, Badat, Aysha, Klug, Eric, Van Zyl, Louis, Abelson, Mark, Moodley, Rajendran, Tsabedze, Nqoba, Fourie, Nyda, Bonet, Luis Almenar, Prado, Jose Maria Arizon, Oliveira Soares, Manue Martinez‐Selles D, Villota, Julio Eduardo Nuñez, Leiro, Maria Generosa Crespo, Juanatey, Jose Ramon Gonzalez, Figal, Domingo Andres Pascual, Palomas, Juan Luis Bonilla, Perez, Sonia Mirabet, Jimenez, Juan Francisco Delgado, Padron, Antonio Lara, Diaz, Victor Alfonso Jimenez, Cubero, Javier Segovia, Paya, Vicente Eduardo Climent, Mayoral, Alejandro Recio, Fuente Galan, Luis, Doblas, Juan Jose Gomez, Freire, Ramon Bover, Peiro, Maria Teresa Blasco, Molina, Beatriz Diaz, Martinez, Laura Jordan, Vilchez, Francisco Gonzalez, Boman, Kurt, Karlstrom, Patric, Berglund, Stefan, Szabo, Barna, Peterson, Magnus, Wodlin, Peter, Lindholm, Carl‐Johan, Moccetti, Tiziano, Mueller, Christian, Suter, Thomas, Hullin, Roger, Meyer, Philippe, Noll, Georg, Yigit, Zerrin, Turgut, Okan Onur, Bekar, Lutfu, Sahin, Tayfun, Koldas, Zehra Lale, Celik, Ahmet, Cavusoglu, Yuksel, Demir, Mesut, Onrat, Ersel, Duzenli, Mehmet, Cosansu, Kahraman, Muderrisoglu, Ibrahim Haldun, Tuncer, Mustafa, Badak, Ozer, Nalbantgil, Sanem, Kirma, Cevat, Okuyan, Ertugrul, Guray, Umit, Prokhorov, Oleksandr, Karpenko, Oleksandr, Vakaliuk, Igor, Yagensky, Andriy, Kracz, Igor, Stanislavchuk, Mykola, Kulynych, Oleksii, Rishko, Mykola, Stets, Roman, Tseluyko, Vira, Mishchenko, Larysa, Rudenko, Leonid, Rudyk, Iurii, Alieksieieva, Liudmyla, Korzh, Oleksii, Mostovoy, Yuriy, Parkhomenko, Oleksandr, Rasputina, Lesya, Voronkov, Leonid, Lymar, Yurii, Vasilyeva, Larysa, Keeling, Philip, Barr, Craig, Wong, Kenneth, Price, Dallas, Skaria, Binoy, Clark, Andrew, Chandrasekaran, Badrinathan, Trevelyan, Jasper, Gordon, Brian, Donnelly, Patrick, Glover, Jason, Ryding, Alisdair, Weir, Robin, Lang, Chim, Roy, Debashis, Adhya, Shaumik, Clifford, Piers, Ludman, Andrew, Kalra, Paul, Lynch, Mary, Mahmood, Shahid, Al Mohammad, Abdallah, Asubiaro, Joshua, Elmahi, Einas, Muthumala, Amal, Taylor, Justin, Gupta, Dinesh, Nadar, Venkatesh, Henderson, David, Zolty, Ronald, Sauer, Andrew, Adams, Kirkwood, Chandra, Lokesh, Jaffrani, Naseem, Grewal, Gurinder, Mancini, Donna, McLean, Dalton, Vasallo, Javier, Gottlieb, Stephen, Joseph, Susan, Barua, Rajat, Gorodeski, Eiran, Mouhaffel, Asad, Chung, Eugene, Desai, Pratik, Portnay, Edward, Rama, Bhola, Shandling, Adrian, Stahl, Llyod, Heilman, Karl, Jacob, Binu, Londono, Juan, Almousalli, Omar, Ashcom, Thomas, Bauerlein, Eugene Joseph, Koo, Charles, McGrew, Frank, Rajagopalan, Navin, Robinson, Shawn, Schultz, David, Starling, Randall, Ambardekar, Amrut, Bhagwat, Ravi, Boehmer, John, Bouza, Manuel, Farris, Neil, Feitell, Scott, Ganji, Jagadeesh, Geltman, Edward, Javier, Julian, Morrow, John Andrew, Pianko, Leonard, Smart, Frank, Adler, Alexander, Brinkley, Douglas, Cardona, Jose, Coletti, Andrew, Harris, John, Hunter, Vernon, Krantz, Mori, Lang, Christopher, Lovell, Charles, Murray, David, Pillutla, Priya, Shah, Amit, Bogaev, Roberta, Dauber, Ira, Franchi, Francesco, Fremont, Richard, Hart, Terence, Hattler, Brack, Janik, Matthew, Khalife, Wissam, Malhotra, Sanjay, Mamdani, Shafiq, Nelson, William, Orgera, Marisa, Ortiz, Aurelio, Rahko, Peter, Rennyson, Stephen, Shin, Jooyoung, Tsao, Lana, Uretsky, Barry, Wahid, Faisal, Wilkett, Matt, Amanullah, Aman, Baker, Mathue, Berk, Martin, Boccalandro, Fernando, Cruz, Kimberly, Doyle, Timothy, Gianfagna, Robert, Jones, Alonzo, King, Anthony, Lepor, Norman, Martinez‐Castrillon, Melvin, Pham, Michael, Radin, Michael, Radojevic, Joseph, Ramanathan, Kodangudi, Schmalfuss, Carsten, Schnitzler, Robert, Shah, Keyur, Takata, Theodore, Bertolet, Barry, Bostick, Brian, Civitello, Andrew, Collins, John, Dib, Nabil, Fang, James, Gilmore, Richard, Gray, Wayne, Grazette, Luanda, Haddad, Tariq, Hearne, Steven, Janmohamed, Munir, Katz, Richard, Kazemi, Navid, Llerena, Sara, Lohr, Nicole, Marzouka, George, Mignone, John, Ooi, Henry, Paszczuk, Anna, Pickett, Christopher, Sampognaro, Gregory, Sawyer, Douglas, Shayani, Steven, Treasure, Charles, Vaz, Garth, Vijay, Nampalli, Williams, Celeste, Yeoman, Gary, Zhang, Lily, Aaronson, Keith, Abo‐Auda, Wael, Alharethi, Rami, Anderson, William, Ariani, Mehrdad, Banerji, Sourin, Baweja, Paramdeep, Carson, Peter, Eberly, Arthur, Elliott, James, Fernando, Ronald, Fisher, Daniel, Forman, Steven, Gabriel, George, Gogia, Harinder, Hametz, Craig, Houston, Brian, Ibrahim, Hassan, Jadbabaie, Farid, Kassiotis, Christos, Krishnamoorthy, Arun, Kwan, Michael, Lupovitch, Steven, Macias, Leonardo, Malik, Adnan, Martinez, Luis, Miyamoto, Michael, Mody, Freny, Patel, Devesh, Peart, Brenda, Pisani, Barbara, Ramos, Mark, Rivero, Mariel, Shah, Anil, Sharma, Mukesh, Sichrovsky, Tina, Simon, Marc, Singh, Deovrat, Tallet, Julio, Vaccari, Christopher, Villoch, Mario, Wheeler, Matthew, Yousuf, Kabir, Abadier, Rafik, Abdullah, Shuaib, Arora, Raveen, Aslam, Shamaila, Buynak, Robert, Chang, David, Contreras, Johanna, Halpern, Stephen, Handel, Franklin, Heitner, John, Herzog, William, Jackson, Bruce, Kao, John, Kondo, Nicholas, Koren, Michael, LeWinter, Martin, Martindale, Jeffrey, Martinez‐Arraras, Joaquin, Olsen, Stephanie, Piatek, Marek, Ranadive, Nandkishore, Randall, William, Rao, Sunder, Rawitscher, David, Rider, James, Sokos, George, Strader, J Russell, Sulemanjee, Nasir, Tahirkheli, Naeem, Trichon, Benjamin, Vanhecke, Thomas, Whellan, David, Abuannadi, Mohammad, Aggarwala, Gaurav, Ahmad, Saad, Artis, Andre, Cheirif, Jorge, Cotarlan, Vladimir, Cox, Jeremy, Eaton, Charles, Florea, Viorel, Frank, Theodore, Friedman, Keith, Ganeshram, Vedampattu, Gass, Alan, Gemignani, Anthony, Hasni, Syed, Hedgepeth, Chester, Itchhaporia, Dipti, Kaluski, Edo, Karim, Amin, Kono, Alan, Lader, Ellis, Lakshminarayanan, Batlagundu, Lewis, Neil, Malhotra, Vinay, Mayer, Nolan, Mohapatra, Robert, Nair, Nandini, O'Brien, Terrence, Pauwaa, Sunil, Rowan, Christopher, Saxena, Sanjeev, Seto, Arnold, Shah, Nishant, Singh, Pradeep, Skopicki, Hal, Stoddard, Marcus, and Sweitzer, Nancy
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R1 - Abstract
Aims:\ud The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.\ud \ud Methods and Results:\ud Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure
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- 2020
10. FOCUS 2: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia
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Low, Donald E., File, Thomas M., Jr, Eckburg, Paul B., Talbot, George H., David Friedland, H., Lee, Jon, Llorens, Lily, Critchley, Ian A., Thye, Dirk A., Corral, Jorge, Giugno, Eduardo, Gonzalez Arzac, Maria del Rosario, Maurizi, Diego, Altclas, Javier, Ambasch, Germán, Jasovich, Abel, Minguez, Angel Ramon, Oliva, Maria Eugenia, Teglia, Osvaldo, Bergallo, Carlos, Mastruzzo, Maria Antonia, Isabel Morera, Graciana, Scapellato, Pabio Gustavo, Lamberghini, Ricardo, Mykietiuk, Analia, Remolif, Christian, Barros Monge, Manuel Jose, Enriqueta Campos Barker, Maria Isabel, Chernilo Steinmann, Sara Mireya, Gaete Gutierrez, Pablo Antonio, Muñoz Vejar, Sylvia Susana, Calvo Arellano, Mario Andres, Chahin Anania, Carolina Eugenia, Jauregui Cruz, Arturo, Amaya Tapia, Gerardo, Acuna Kaldman, Moises, Noriega, Eduardo, Matos Prado, Eduardo Demetrio, Ramos, Carlos, Andreeva, Irina, Abyshev, Rashad, Antonovsky, Yuri A., Balyuzek, Marina, Esina, Alla L., Gorelov, Alexander, Khrustalev, Oleg A., Kozlov, Roman S., Novozhenok, Vladislav, Popova, Veronika B., Sobchenko, Svetlana, Trofimov, Vasily, Yakovlev, Sergey, Zhidkov, Konstantin, Ambert, Luminta Gabriela, Fierbinteau, Carmen Georgeta, Ionescu, Valentina, Muresan, Mihai Marius, Tanaseanu, Cristina Mihaela, Georgiev, Ognian, Hodzhev, Valdimir, Marinov, Rosen, Metev, Hristo, Peneva, Marinka, Popov, Dimitar, Simeonova, Milkana, Krastins, Ivars, Lovcinovsk, Viktors, Silins, Viesturs, Svarcberga, Vita, Bargon, Joachim, Bauer, Thorsten, Bergmann, Rolf, Meyer, F.J., Mueller, Thomas, Welte, Tobias, Glaeser, Sven, Hammerl, Peter, Kern, Hartmut, Krueger, Stefan, Kujath, Peter, Lies, Achim, Schaberg, Tom, Schmalz, Oliver, Schütte, Wolfgang, Chazan, Ryszarda, Górecka, Dorota, Rogala, Barbara, Antczak, Adam, Grodzicki, Tomasz, JahnzRö, Karina, Milanowski, Janusz, Nalepa, Piotr, Wróbel-Rajzer, Malgorzata, Szelerska-Twardosz, Hanna, GrzelewskaRzymowska, Iwona, Kachel, Tomasz, Marciniak, Andrzej, Panaszek, Bernard, Szczeklik, Andrzej, Kozielski, Jerzy, Harat, Rafal, Jastrzebsk, Dariusz, Juszczak, Jacek, Labij, Violetta, Vetter, Norbert, Bolitschek, Josef, Eckmayr, Josef, Molnár, Sándor, Pápai-Székely, Zsolt, Szegedi, Janos, Vinkler, Ilona, Borscchivskyy, Mykhaylo, Dziublyk, Oleksandr, Dzyak, Georgiy V., Kraydaschenko, Oleg, Mostovoy, Yuriy M., Rudyk, Iurii S., Sushko, Viktor, Vizir, Vadim, Bhattacharya, Amal Kumar, Chakrapan, Mahabala, DʼSouza, George, Malpani, G.S., Mehta, Parthiv, Rao, K.N. Mohar, and Talwar, Deepak
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- 2011
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11. THE EFFECT OF BETA-BLOCKERS ON A COURSE OF CHRONIC HEART FAILURE IN PATIENTS WITH A LOW TRIIODOTHYRONINE SYNDROME
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Pyvovar, Sergiy M., primary, Rudyk, Iurii S., additional, Kopytsya, Mykola P., additional, Lozyk, Tetiana V., additional, Galchinskaya, Valentina Ir., additional, and Chenchik, Tetiana O., additional
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- 2020
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12. The polymorphisms of beta-adrenergic receptors genes and a risk of atrial fibrillation development in patients with a heart failure
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Pyvovar, Sergiy, primary, Rudyk, Iurii, additional, Lozyk, Tatyana, additional, Galchinskaya, Valentina, additional, and Bondar, Tatiana, additional
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- 2019
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13. Promising Role of Vascular Endothelial Growth Factor-A in Risk Stratification after PCI
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V., Petyunina, Olga, P., Kopytsya, Mykola, S., Rudyk, Iurii, and S., Isayeva, Ganna
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InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Published
- 2019
14. Forecasting the course of a heart failure in patients with a non-toxic goiter, accounting function of the thyroid gland
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Pyvovar, Sergiy, Rudyk, Iurii, Lozyk, Tetiana, Galchinska, Valentyna, and Chenchik, Tetiana
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серцева недостатність ,нетоксичний зоб ,синдром «низького трийодтироніну» ,ризик ,перебіг ,прогнозування ,УДК: 616-005.4:616.441-006.5:575.191:615.37 ,сердечная недостаточность ,нетоксический зоб ,синдром «низкого трийодтиронина» ,риск ,течение ,прогнозирование ,heart failure ,non-toxic goiter ,"low T3" syndrome ,risk ,course ,prognosis - Abstract
Мета роботи: встановити прогностичні критерії перебігу серцевої недостатності у хворих з нетоксичним зобом.Матеріал та методи. Включено 381 хворих з серцевою недостатністю на фоні післяінфарктного кардіосклерозу. Із них 218 хворих мали нетоксичний зоб. Визначали рівні ТТГ, T3в, T4в, Т3r, NT-proBNP. Проводили ехокардіоскопію, ультразвукове дослідження щитоподібної залози. Вивчали перебіг серцевої недостатності протягом 2 років.Результати. Серед хворих з серцевою недостатністю, що плине на фоні нетоксичного зобу, у порівнянні до пацієнтів без такого є більший відсоток жінок (відповідно у 42,7 % проти 16,6 %, р = 0,001), частіше реєструється IV ФК NYHA (відповідно - 13,3 %, проти 5,5 %; р = 0,043), на 33,4 % вищий рівень NT-proBNP (р = 0,001) та менший сироватковий вміст Т3в (2,30 пмоль/л проти 2,76 пмоль/л, р = 0,0001); більші: на 3,8 % кінцево-діастолічний розмір лівого шлуночка (р = 0,006), на 8,9 % кінцево-діастолічний об’єм (р = 0,006), на 5,4 % кінцево-систолічний розмір (р = 0,002), на 13,2 % кінцево-систолічний об’єм (р = 0,002); менша на 6,5 % фракція викиду (р = 0,02); більша частота синдрому «низького трийодтироніну» (ВШ = 7,94 (4,04 – 15,61), р = 0,0001) та субклінічного гіпотиреозу (ВШ = 5,21 (1,52 – 17,90), р = 0,004); вищий ризик повторної госпіталізації (ВШ = 3,037 (1,85 – 4,99), р = 0,0001) та комбінованої кінцевої точки (ВШ = 2,53 (1,60 - 3,995), р = 0,001). Хворі з нетоксичним зобом без синдрому «низького трийодтироніну» не мають вірогідної різниці за перебігом серцевої недостатності. У групі хворих з серцевою недостатністю, що плине на фоні нетоксичного зоба та синдрому «низького трийодтироніну» зростають ризики повторної госпіталізації (ВШ = 6,82 (1,38 – 33,72), р = 0,022) та досягнення комбінованої кінцевої точки (ВШ = 4,76 (1,17 – 19,41), р = 0,047) протягом 2 років спостереження.Висновки. При серцевій недостатності з нетоксичним зобом, за наявності синдрому низького трийодтироніну, можливо прогнозувати несприятливий дворічний перебіг: високий ризик повторної госпіталізації, комбінованої кінцевої точки, Цель работы: определить прогностические критерии течения сердечной недостаточности у больных с нетоксическим зобом.Материал и методы. Включено 381 больных с сердечной недостаточностью на фоне постинфарктного кардиосклероза. Из них, 218 больных имели нетоксический зоб. Определяли уровни ТТГ, T3св, T4св, Т3r, NT-proBNP. Проводили эхокардиоскопию, ультразвуковое исследование щитовидной железы. Изучали течение сердечной недостаточности на протяжении 2 лет.Результаты. Среди больных с сердечной недостаточностью, протекающей на фоне нетоксического зоба, по сравнению с пациентами без такового - больший процент женщин (соответственно в 42,7 % против 16,6 %, при р = 0,001), чаще регистрируется IV ФК NYHA (соответственно - 13,3 %, против 5,5 %; р = 0,043), на 33,4 % выше уровень NT-proBNP (р = 0,001) и меньше сывороточное содержание Т3св (2,30 пмоль / л против 2,76 пмоль / л , при р = 0,0001); больше: на 3,8 % конечно-диастолический размер левого желудочка (р = 0,006), на 8,9 % конечно-диастолический объем (р = 0,006), на 5,4 % конечно- систолический размер (р = 0,002) на 13,2 % конечно-систолический объем (р = 0,002) меньше на 6,5 % фракция выброса (р = 0,02); большая частота синдрома «низкого трийодтиронина» (ОШ = 7,94 (4,04 - 15,61), р = 0,0001) и субклинического гипотиреоза (ОШ = 5,21 (1,52 - 17,90), р = 0,004), высокий риск повторной госпитализации (ОШ = 3,037 (1,85 - 4,99), р = 0,0001) и комбинированной конечной точки (ОШ = 2,53 (1,60 - 3,995), р = 0,001). Больные с нетоксическим зобом без синдрома «низкого трийодтиронина» не имеют достоверной разницы в течении сердечной недостаточности. В группе больных с сердечной недостаточностью на фоне нетоксического зоба и синдрома «низкого трийодтиронина» возрастают риски повторной госпитализации (ОШ = 6,82 (1,38 - 33,72), р = 0,022) и достижения комбинированной конечной точки (ОШ = 4,76 (1,17 - 19,41), р = 0,047) на протяжении 2 лет наблюдения.Выводы. У больных с сердечной недостаточностью, протекающей на фоне сочетания нетоксического зоба и синдрома «низкого трийодтиронина», возможно прогнозировать неблагоприятное течение на протяжении 2 лет: высокий риск повторной госпитализации, комбинированной конечной точки, The aim: to determine prognostic criteria for the course of heart failure in patients with non-toxic goiter.Material and methods. In the study 381 patients with heart failure on the background of post-infarction cardiosclerosis were included. Of these, 218 patients had non-toxic goiter. The levels of TSH, T3fr, T4fr, T3r, NT-proBNP were evaluated. An echocardioscopy, an ultrasound examination of the thyroid gland were conducted. We studied the course of heart failure for 2 years.Results. In patients with heart failure that occurs on the background of non-toxic goiter, compared to patients without it, a percentage of women is higher (respectively, 42.7 % versus 16.6 %, at p=0.001); they more often have IV NYHA FC (respectively – 13.3 %, against 5.5 %; p=0.043), 33.4 % higher level of NT-proBNP (p=0.001) and lower serum content of T3fr (2.30 pmol/L vs 2.76 pmol/L , at p=0.0001); higher end-diastolic dimension of the left ventricle by 3.8 % (p=0.006), end-diastolic volume by 8.9 % (p=0.006), end-systolic dimension by 5.4 % (p=0.002), end-systolic volume by 13.2 % (p=0.002), 6.5 % less ejection fraction (p=0.02); high frequency of the "low T3" syndrome (odd ratio (OR)=7.94 (4.04–15.61), p=0.0001) and subclinical hypothyroidism (OR=5.21 (1.52–17.90), p=0.004), a high risk of re-hospitalization (OR=3.037 (1.85–4.99), p=0.0001) and a composite endpoint (OR=2.53 (1.60–3.995), p=0.001). Patients with non-toxic goiter without the "low T3" syndrome did not have a significant difference in the course of heart failure. In the group of patients with heart failure that flew on the background of non-toxic goiter and “low T3“ syndrome, there were high risks of re-hospitalization (OR=6.82 (1.38–33.72), p=0.022) and achievement of the composite endpoint (OR=4.76 (1.17–19.41), p=0.047) during 2 years of observation.Conclusions. In heart failure with non-toxic goiter, with the "low T3" syndrome, it is possible to predict an unfavorable decease course during 2 years of observation: a high risk of re-hospitalization and composite endpoint
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- 2019
15. The polymorphisms of beta-adrenergic receptors genes and a risk of atrial fibrillation development in patients with a heart failure
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Pyvovar, Sergiy; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Rudyk, Iurii; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Lozyk, Tatyana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Galchinskaya, Valentina; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Bondar, Tatiana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Pyvovar, Sergiy; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Rudyk, Iurii; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Lozyk, Tatyana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Galchinskaya, Valentina; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, and Bondar, Tatiana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039
- Abstract
Objective: to study the relationship of gene polymorphisms of the b-adrenoreception system with the risk of atrial fibrillation in patients with heart failure.Material and methods. 286 patients with heart failure on the background of post-infarction cardiosclerosis were included. Of these, 25 (8.7 %) patients had the atrial fibrillation. The genotyping was performed using 4 polymorphisms (Gly389Arg of the b1-adrenoreceptors gene, Ser49Gly of the b1-adrenoreceptors gene, Gln27Glu of the b2-adrenoreceptors gene and Ser275 of the b3-subunit of G-protein gene) using the polymerase chain reaction. The genetic and epidemiological analysis was carried out using the SNPStats program.Results. Patients with heart failure with the G / C genotype of Gly389Arg polymorphism of the b1-adrenoreceptors gene have a lower risk of developing atrial fibrillation (OR=0.14 (0.03–0.61), p=0.0043, co-dominant model of heredity).The data on a decrease in the risk of atrial fibrillation in patients with heart failure and with the G/C genotype Gly389Arg polymorphism of the b1-adrenoreceptors gene are also confirmed in the overdominant (OR=0.15 (0.03–0.64), p=0.0012), as well as in the dominant (OR=0.23 (0.08-0.69), p=0.0029) and the log-additive (OR=0.40 (0.17-0.94), p=0.019) models.Findings. The results allow us to conclude that congenital genetic differences in the pathways of b-adrenoreception can be associated with the development of atrial fibrillation in patients with heart failure, Цель работы: изучить взаимосвязь полиморфизмов генов системы b-адренорецепции с риском развития фибрилляции предсердий у больных с сердечной недостаточностью.Материал и методы. Включено 286 больных с сердечной недостаточностью на фоне постинфарктного кардиосклероза. Из них, 25 (8,7 %) больных имели фибрилляцию предсердий. Проводилось генотипирование по 4 полиморфизмам (Gly389Arg гена b1-адренорецепторов, Ser49Gly гена b1-адренорецепторов, Gln27Glu гена b2-адренорецепторов и Ser275 гена b3-субодиницы G-протеина) при помощи полимеразно-цепной реакции. Генетико-эпидемиологический анализ осуществлялся с помощью программы SNPStats.Результаты. Пациенты с сердечной недостаточностью с генотипом G / C полиморфизма Gly389Arg гена b1-адренорецепторов имеют более низкий риск развития фибрилляции предсердий (ОШ = 0,14 (0,03-0,61), р=0,0043, ко-доминантная модель наследственности).Данные о снижении риска фибрилляции предсердий у больных с сердечной недостаточностью при генотипе G / C полиморфизма - Gly389Arg гена b1-аренорецепторов подтверждаются и в чрезмерно-доминантной (ОШ = 0,15 (0,03-0,64), р=0,0012), а также в доминантной (ОШ=0,23 (0,08-0,69), р=0,0029) и лог-аддитивной (ОШ=0,40 (0,17-0,94), р = 0,019) моделях наследственности.Выводы. Полученные результаты позволяют сделать вывод о том, что врожденные генетические различия в путях b-адренорецепции могут быть связаны с развитием фибрилляции предсердий у больных с сердечной недостатнисю, Мета роботи: вивчити взаємозв’язок поліморфізмів генів системи b-адренорецепції з ризиком розвитку фібриляції передсердь у хворих з серцевою недостатністю.Матеріал та методи. Включено 286 хворих з серцевою недостатністю на фоні післяінфарктного кардіосклерозу. Із них, 25 (8,7 %) хворих мали фібриляцію передсердь. Проводилось генотипування за 4 поліморфізмами (Gly389Arg гена b1-адренорецепторів, Ser49Gly гена b1- адренорецепторів, Gln27Glu гена b2-адренорецепторів та Ser275 гена b3-субодиниці G-протеїна) за допомогою полімеразноланцюгової реакції. Генетико-епідеміологічний аналіз здійснювався за допомогою програми SNPStats.Результати. Пацієнти з серцевою недостатністю з генотипом G/C поліморфізму Gly389Arg гена b1-адренорецепторів мають нижчий ризик розвитку фібриляції передсердь (ВШ=0,14 (0,03-0,61), р=0,0043, ко-домінантна модель спадковості).Дані про зниження ризику фібриляції передсердь у хворих з серцевою недостатністю при генотипі G/C поліморфізму - Gly389Arg гена b1-аренорецепторів підтверджуються й у надмірно-домінантній (ВШ = 0,15 (0,03-0,64), р = 0,0012), у домінантній (ВШ = 0,23 (0,08-0,69), р = 0,0029) та лог-аддитивній (ВШ = 0,40 (0,17-0,94), р = 0,019) моделях спадковості.Висновки. Отримані результати дозволяють зробити висновок про те, що вроджені генетичні відмінності в шляхах b-адренорецепції можуть бути пов’язані з розвитком фібриляції передсердь у хворих з серцевою недостатністю
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- 2019
16. Forecasting the course of a heart failure in patients with a non-toxic goiter, accounting function of the thyroid gland
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Pyvovar, Sergiy; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Rudyk, Iurii; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Lozyk, Tetiana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Galchinska, Valentyna; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Chenchik, Tetiana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Pyvovar, Sergiy; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Rudyk, Iurii; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Lozyk, Tetiana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, Galchinska, Valentyna; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039, and Chenchik, Tetiana; Державна установа «Національний Інститут терапії ім. Л. Т. Малої Національної академії медичних наук України» пр. Л. Малої, 2 а, м. Харків, Україна, 61039
- Abstract
The aim: to determine prognostic criteria for the course of heart failure in patients with non-toxic goiter.Material and methods. In the study 381 patients with heart failure on the background of post-infarction cardiosclerosis were included. Of these, 218 patients had non-toxic goiter. The levels of TSH, T3fr, T4fr, T3r, NT-proBNP were evaluated. An echocardioscopy, an ultrasound examination of the thyroid gland were conducted. We studied the course of heart failure for 2 years.Results. In patients with heart failure that occurs on the background of non-toxic goiter, compared to patients without it, a percentage of women is higher (respectively, 42.7 % versus 16.6 %, at p=0.001); they more often have IV NYHA FC (respectively – 13.3 %, against 5.5 %; p=0.043), 33.4 % higher level of NT-proBNP (p=0.001) and lower serum content of T3fr (2.30 pmol/L vs 2.76 pmol/L , at p=0.0001); higher end-diastolic dimension of the left ventricle by 3.8 % (p=0.006), end-diastolic volume by 8.9 % (p=0.006), end-systolic dimension by 5.4 % (p=0.002), end-systolic volume by 13.2 % (p=0.002), 6.5 % less ejection fraction (p=0.02); high frequency of the "low T3" syndrome (odd ratio (OR)=7.94 (4.04–15.61), p=0.0001) and subclinical hypothyroidism (OR=5.21 (1.52–17.90), p=0.004), a high risk of re-hospitalization (OR=3.037 (1.85–4.99), p=0.0001) and a composite endpoint (OR=2.53 (1.60–3.995), p=0.001). Patients with non-toxic goiter without the "low T3" syndrome did not have a significant difference in the course of heart failure. In the group of patients with heart failure that flew on the background of non-toxic goiter and “low T3“ syndrome, there were high risks of re-hospitalization (OR=6.82 (1.38–33.72), p=0.022) and achievement of the composite endpoint (OR=4.76 (1.17–19.41), p=0.047) during 2 years of observation.Conclusions. In heart failure with non-toxic goiter, with the "low T3" syndrome, it is possible to predict an unfavorable decease course during 2 years of observation: a hig, Цель работы: определить прогностические критерии течения сердечной недостаточности у больных с нетоксическим зобом.Материал и методы. Включено 381 больных с сердечной недостаточностью на фоне постинфарктного кардиосклероза. Из них, 218 больных имели нетоксический зоб. Определяли уровни ТТГ, T3св, T4св, Т3r, NT-proBNP. Проводили эхокардиоскопию, ультразвуковое исследование щитовидной железы. Изучали течение сердечной недостаточности на протяжении 2 лет.Результаты. Среди больных с сердечной недостаточностью, протекающей на фоне нетоксического зоба, по сравнению с пациентами без такового - больший процент женщин (соответственно в 42,7 % против 16,6 %, при р = 0,001), чаще регистрируется IV ФК NYHA (соответственно - 13,3 %, против 5,5 %; р = 0,043), на 33,4 % выше уровень NT-proBNP (р = 0,001) и меньше сывороточное содержание Т3св (2,30 пмоль / л против 2,76 пмоль / л , при р = 0,0001); больше: на 3,8 % конечно-диастолический размер левого желудочка (р = 0,006), на 8,9 % конечно-диастолический объем (р = 0,006), на 5,4 % конечно- систолический размер (р = 0,002) на 13,2 % конечно-систолический объем (р = 0,002) меньше на 6,5 % фракция выброса (р = 0,02); большая частота синдрома «низкого трийодтиронина» (ОШ = 7,94 (4,04 - 15,61), р = 0,0001) и субклинического гипотиреоза (ОШ = 5,21 (1,52 - 17,90), р = 0,004), высокий риск повторной госпитализации (ОШ = 3,037 (1,85 - 4,99), р = 0,0001) и комбинированной конечной точки (ОШ = 2,53 (1,60 - 3,995), р = 0,001). Больные с нетоксическим зобом без синдрома «низкого трийодтиронина» не имеют достоверной разницы в течении сердечной недостаточности. В группе больных с сердечной недостаточностью на фоне нетоксического зоба и синдрома «низкого трийодтиронина» возрастают риски повторной госпитализации (ОШ = 6,82 (1,38 - 33,72), р = 0,022) и достижения комбинированной конечной точки (ОШ = 4,76 (1,17 - 19,41), р = 0,047) на протяжении 2 лет наблюдения.Выводы. У больных с сердечной недостаточностью, протекающей на фоне сочетания нетоксиче, Мета роботи: встановити прогностичні критерії перебігу серцевої недостатності у хворих з нетоксичним зобом.Матеріал та методи. Включено 381 хворих з серцевою недостатністю на фоні післяінфарктного кардіосклерозу. Із них 218 хворих мали нетоксичний зоб. Визначали рівні ТТГ, T3в, T4в, Т3r, NT-proBNP. Проводили ехокардіоскопію, ультразвукове дослідження щитоподібної залози. Вивчали перебіг серцевої недостатності протягом 2 років.Результати. Серед хворих з серцевою недостатністю, що плине на фоні нетоксичного зобу, у порівнянні до пацієнтів без такого є більший відсоток жінок (відповідно у 42,7 % проти 16,6 %, р = 0,001), частіше реєструється IV ФК NYHA (відповідно - 13,3 %, проти 5,5 %; р = 0,043), на 33,4 % вищий рівень NT-proBNP (р = 0,001) та менший сироватковий вміст Т3в (2,30 пмоль/л проти 2,76 пмоль/л, р = 0,0001); більші: на 3,8 % кінцево-діастолічний розмір лівого шлуночка (р = 0,006), на 8,9 % кінцево-діастолічний об’єм (р = 0,006), на 5,4 % кінцево-систолічний розмір (р = 0,002), на 13,2 % кінцево-систолічний об’єм (р = 0,002); менша на 6,5 % фракція викиду (р = 0,02); більша частота синдрому «низького трийодтироніну» (ВШ = 7,94 (4,04 – 15,61), р = 0,0001) та субклінічного гіпотиреозу (ВШ = 5,21 (1,52 – 17,90), р = 0,004); вищий ризик повторної госпіталізації (ВШ = 3,037 (1,85 – 4,99), р = 0,0001) та комбінованої кінцевої точки (ВШ = 2,53 (1,60 - 3,995), р = 0,001). Хворі з нетоксичним зобом без синдрому «низького трийодтироніну» не мають вірогідної різниці за перебігом серцевої недостатності. У групі хворих з серцевою недостатністю, що плине на фоні нетоксичного зоба та синдрому «низького трийодтироніну» зростають ризики повторної госпіталізації (ВШ = 6,82 (1,38 – 33,72), р = 0,022) та досягнення комбінованої кінцевої точки (ВШ = 4,76 (1,17 – 19,41), р = 0,047) протягом 2 років спостереження.Висновки. При серцевій недостатності з нетоксичним зобом, за наявності синдрому низького трийодтироніну, можливо прогнозувати несприятливий дворічний перебіг: високий ри
- Published
- 2019
17. Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF
- Author
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Butler, Amy, Elmersson, Micael, Egilsson, Arnor, Borjesson, Ulf, Svard, Gunnar, Liu, Bo, Lindh, Anders, Olsson, Lars-Bertil, Gustaysson, Mikael, Andersson, Lars, Benson, Lars, Bothin, Claes, Hajimirsadeghi, Ali, Martinsson, Bjorn, Ericsson, Marianne, Ohlsson, Ake, Lindvall, Hakan, Svensson, Peter, Thorne, Katarina, Handel, Hans, Platonov, Pyotr, Bernsten, Fredrik, Timberg, Ingar, Crisby, Milita, Karlsson, Jan-Erik, Andersson, Agneta, Malmqvist, Lennart, Engdahl, Johan, Thulin, Jorgen, Hot-Bjelak, Aida, Jensen, Steen, Debrunner, Johann, Beer, Juerg H., Shah, Dipen, Rudyk, Iurii, Tseluyko, Vira, Karpenko, Oleksandr, Zhurba, Svitlana, Kraiz, Igor, Parkhomenko, Oleksandr, Kupnovytska, Iryna, Seredyuk, Nestor, Mostovoy, Yuriy, Ushakov, Oleksiy, Koval, Olena, Kovalskiy, Igor, Svyshchenko, Yevgeniya, Sychov, Oleg, Stanislavchuk, Mykola, Tykhonova, Susanna, Fushtey, Ivan, Murdoch, Will, Chauhan, Naresh, Goodwin, Daryl, Lumley, Louise, Patel, Ramila, Saunders, Philip, Wong, Bennett, Patel, Niranjan, Jhittay, P., Ross, Andrew, Kainth, M. S., Ladha, Karim, Douglas, Kevin, Pickavance, Gill, McDonnell, Joanna, Handscombe, Laura, Gooding, Trevor, Wagner, Helga, Bradshaw, Colin, Bromham, Catherine, Jones, Kevin, Suryani, Shoeb, Coates, Richard, Sarai, Bhupinder, Willcock, W., Sircar, S., Cairns, John, Gilliand, A., Bilas, Roman, Strieder, E., Hutchinson, Peter, Wakeman, Anne, Stokes, Michael, Kirby, Graham, Vishwanathan, Bhaskhar, Vormann, Reinhold, Mueller, Thomas, Mayer, Peter, Horstmeier, Uwe, Eissing, Volker, Hey, Heinz, Leuchtgens, Heinz, Lilienweiss, Volker, Mueller, Heiner, Schubert, Christian, Lauer, Hellmann, Buchner, Thomas, Brauer, Gunter, Kamin, Susanne, Mueller, Karsten, Baumbach, Sylvia, Abdel-Qader, Muwafeg, Ebert, Hans-Holger, Schwencke, Carsten, Bernhardt, Peter, Karolyi, Laszlo, Sievers, Britta, Haverkamp, Wilhelm, Roehnisch, Jens-Uwe, Vertes, Andras, Szantai, Gabor, Menke, Holger, Matoltsy, Andras, Kanakaridisz, Nikosz, Boda, Zoltan, Kis, Erno, Gaszner, Balazs, Juhasz, Ferenc, Kamogawa, Yasuyuki, Fournier, Pierre-Yves, Muller, Jean-Joseph, Marquand, Andre, Delarche, Nicolas, Bantwal, Ganapathi, Faes, Dirk, Verstraete, Stefan, Dominguez, Helena, Topsakal, Ramazan, Centurion, Nestor, Alfredo Sinisi, Victor, Minc, Piotr, Nagy, Andras, Bilo, Grzegorz, Bongiorni, Maria Grazia, Bird, Nigel, Paul, Carolyn, Wadeson, Paul, Hargreaves, Nick, Kostenko, Victor, Tercedor Sanchez, Luis, Tranche Iparraguirre, Salvador, Jimenez Gonzalez, Mercedes, Herreros Melenchon, Juan, Stalby, Per, Yagensky, Andriy, Cameron, Alex, Jacobs, Polly, Juhasz, Gizella, Kancz, Sandor, Laszlo, Zoltan, May, Zsolt, Astridge, Penny, Loghdey, Rehana, Quick, Annette, Yang, Ping, Chen, Yingmin, He, Shenghu, Wang, Yong, Fu, Guosheng, Li, Xin, Wu, Tongguo, Cheng, Xiaoshu, Yan, Xiaowei, Zhao, Ruiping, Chen, Moshui, Xiong, Longgen, Chen, Ping, Jiao, Yang, Guo, Ying, Xue, Li, Yang, Zhiming, Jadhavm, Praveen, Merkely, Bela, Noon, Ebrahim, Habon, Tamas, Polgar, Peter, Szalai, Gabriella, Vangel, Sandor, Sarma, Raghava, Kulkarni, Govind, Engelthaler, Gabriella, Ferenczi, Judit, Chandwani, Prakash, Pothiwala, Rasesh Atulbhai, Purayil, Mohanan Padinhare, Chawla, Kamaldeep, Verheugt, Freek W. A., Ambrosio, Giuseppe, Atar, Dan, Bassand, Jean-Pierre, Costabel, Juan Pablo, Goldhaber, Samuel Z., Goto, Shinya, Egyutt, Mihaly, Martini, Giuliana, Cristina, Leone Maria, Tirafern, Eros, Santoro, Rita, Testa, Sophie, Di Minno, Giovanni, Moia, Marco, Caimi, Teresa Maria, Tessitori, Maria, Cappelli, Roberto, Accogli, Michele, Mariani, Antonio, Feola, Mauro, Raisaro, Arturo, Fattore, Luciano, Mauric, Andrea, Germini, Fabrizio, Tedeschi, Luca, Settimi, Maria, Nicoli, Sergio, Ricciarini, Paolo, Argena, Antonio, Ronchini, Paolo, Bulla, Claudio, Tradati, Filippo, Volpe, Massimo, Avino, Maria D., Seven, Silva, Capucci, Alessandro, Lodigiani, Corrado, Salomone, Enrico, Serviddio, Gaetano, Tondo, Claudio, Golino, Paolo, Mazzone, Carmine, Iacopino, Saverio, Ruiter, J. H., Lucassen, Andreas, Adriaansen, Henk, Bongaerts, Maarten, Pieterse, Mathijs, van Guldener, Coen, Herrman, Johannes, Nierop, S. H. K. P. R., Hoogslag, Pieter, Hermans, Walter, Groenemeijer, B. E., Terpstra, W., Buiks, Cees, Boersma, L. V. A., Berge, Eivind, Sirnes, Per Anton, Gjertsen, Erik, Hole, Torstein, Erga, Knut, Hallaraker, Arne, Skjelvan, Gunnar, Ostrem, Anders, Ghezai, Beraki, Svilaas, Arne, Christersson, Peter, Oien, Torbjorn, Henrichsen, Svein Hoegh, Otterstad, Jan Erik, Berg-Johansen, Jan, Gieroba, Andrzej, Biedrzycka, Malgorzata, Ogorek, Michal, Wozakowska-Kaplon, Beata, Loboz-Grudzien, Krystyna, Jaroslaw, Jaroslaw, Supinski, Wieslaw, Kuzniar, Jerzy, Zaluska, Roman, Hiczkiewicz, Jaroslaw, Swiatkowska-Byczynska, Lucyna, Kucharski, Lech, Gruchala, Marcin, Olszewski, Maciej, Kania, Grzegorz, Krzciuk, Malgorzata, Lajkowski, Zbigniew, Ostrowska-Pomian, Bozenna, Lewczuk, Jerzy, Zinka, Elzbieta, Karczmarczyk, Agnieszka, Chmielnicka-Pruszczynska, Malgorzata, Wozniak-Skowerska, Iwona, Opolski, Grzegorz, Bronisz, Marek, Ogorek, Marcin, Glanowska, Grazyna, Ruszkowski, Piotr, Skonieczny, Grzegorz, Sciborski, Ryszard, Okopien, Boguslaw, Kukla, Piotr, Galbas, Krzysztof, Cymerman, Krzysztof, Jurowiecki, Jaroslaw, Miekus, Pawel, Myszka, Waldemar, Mazur, Stanislaw, Lysek, Roman, Baszak, Jacek, Rusicka-Piekarz, Teresa, Raczak, Grzegorz, Domanska, Ewa, Nessler, Jadwiga, Catanchin, Andrei, Colquhoun, David, Kiat, Hosen, Eccleston, David, French, John, Ayres, Bronte, Blombery, Peter, Phan, Thanh, Rogers, James, O'Donnell, David, Cheol, Sang, Carroll, Patrick, Starmer, Greg, Arstall, Margaret, Binnekamp, Maurits, Lee, Astin, Luton, Robert, Gupta, Milan, Pandey, Amritanshu Shekhar, Cheung, Stephen, Leader, Rolland, Beaudry, Philippe, Ayala-Paredes, Felix, Berlingieri, Joseph, Heath, John, Poirier, Germain, du Preez, Miranda, Schweitzer, Bradley, Nadeau, Reginald, Dhillon, Ripple, Hruczkowski, Tomasz, Lavoie, Andrea, Parkash, Ratika, Cha, James, Coutu, Benoit, MacDonald, Paul, Ramjattan, Brian, Bonet, Jorge, Vizel, Saul, Angaran, Paul, Fikry, Sameh, Mowafy, Ahmed, Katta, Azza, Tawfik, Mazen, Nawar, Moustafa, Sobhy, Mohamed, Abou Seif, Seif Kamal, Khairy, Tarek, Abd El-Aziz, Ahmed, Taha, Nasser, Reda, Ashraf, Elbahry, Atef, Setiha, Mohamed, El Din, Mohamed Gamal, Elkhadem, Magdi, El-Etreby, Adel, Kettles, David, Bayat, Junaid, Siebert, Heidi, Horak, Adrian, Kelfkens, Ynez, Garda, Riaz, Pillay, Thayabran, Guerra, Michele, van Zyl, Louis, Theron, Hendrik, Murray, Andrew, Louw, Rikus, Greyling, Deon, Mntla, Pindile, Ismail, Siddique, Ahmed, Fayzal, Engelbrecht, Johannes, Maharajh, Shambu, Oosthuysen, Wessel, Ueckermann, Veronica, Al Naeemi, Abdullah, Yousef, Ghazi, Bazargani, Nooshin, Alomairi, Munther, Maruthanayagam, Rajan, Singh, Rupesh, Naguib, Ahmed, Ibrahim, Mohamed, Agrawal, Amrish, Nathani, Mukesh, Esheiba, Ehab M., Wassef, Adel, Gupta, Rajeev, Cox, Michael, Beach, Scott, Duffy, Peter, Falkowski, Stephen, Ferrick, Kevin, Franco, Miguel, Kutayli, W. Michael, Sharma, Niraj, Wilson, Vance, Miller, Stephen, Alberts, Mark, Blumberg, Edwin, Canosa, Roddy, Gutowski, Ted, Ison, Rodney, Garcia, Jorge, Mullen, Paul, Noveck, Howard, Rama, Pamela, Reddy, Rajneesh, Williams, Marcus, Nishijima, Daniel, Ferdinand, Keith, Hague, Ihsan, Mendelson, Robert, Pitta, Sridevi, Theodoro, Daniel, Treasure, Charles, Moustafa, Moustafa, Cader, Cas, Pharr, Walter, Oropallo, Alisha, Platt, George, Gujral, Jaspal, Welker, James, Koura, Firas, Lesnik, Jozef, Eltishcheva, Vera, Libis, Roman, Kamalov, Gadel, Belenky, Dmitry, Egorova, Liudmila, Khokhlov, Alexander, Yakupov, Eduard, Zateyshchikov, Dmitry, Barbarash, Olga, Miller, Olga, Mazur, Evgeniy, Zrazhevskiy, Konstantin, Novikova, Tatyana, Moiseeva, Yulia, Polkanova, Elena, Sobolev, Konstantin, Rossovskaya, Maria, Shapovalova, Yulia, Kolesnikova, Alla, Nikolaev, Konstantin, Zemlianskaia, Oksana, Zateyshchikova, Anna, Popov, Sergey, Poltayskaya, Maria, Edin, Anton, Aleksandrova, Elena, Drapkina, Oksana, Vishnevsky, Alexander, Nagibovich, Oleg, Chizhov, Petr, Rachkova, Svetlana, Sergeev, Mikhail, Kurylo, Borys, Ushakov, Alexey, Alvarez Garcia, Pere, Lopez Fernandez, Maria Fernanda, Toran Monserrat, Pere, Marquez Contreras, Emilio, Isart Rafecas, Jordi, Motero Carrasco, Juan, Garcia Pavia, Pablo, Gomez Pajuelo, Casimiro, Rincon Diaz, Luis Miguel, Iglesias Alonso, Luis Fernando, Grande Ruiz, Angel, Merce Klein, Jordi, Gonzalez Juanatey, Jose Ramon, Monte Collado, Ines, Palacin Piquero, Herminia, Brotons Cuixart, Carles, Fernandez Escobar, Esther, Bayo i Llibre, Joan, Corros Vicente, Cecilia, Vida Gutierrez, Manuel, Evans, Paul, Clark, M., Bisatt, John, Litchfield, Jennifer, Fisher, E., Fooks, Tim, Kelsall, Richard, Paul, Neil, Alborough, Elizabeth, Aziz, Michael, Ramesh, C., Wilson, Pete, Franklin, Simon, Fairhead, Sue, Thompson, Julian, Chowan, Hasan, Taylor, Gary, Tragen, Dawn, Parfitt, Matt, Seamark, Claire, Richardson, Mark, Jefferies, Angus, Sharp, Helen, Jones, Hywel, Giles, Claire, Bramley, Matthew, Williams, Philip, Aldegather, Jehad, Wetherell, Simon, Lumb, William, Evans, Phil, Scouller, Frances, Macey, Neil, Rogers, Stephen, Stipp, Yvette, West, Richard, Pinney, Philip, Matthews, John, Pandya, Preeti, Gallagher, Andrew, Railton, T., Davies, Emyr, McClure, Jonathan, Jacobs, Marc, Hutton, Claire, Thompson, R., Sinha, Bijoy, Butter, Keith, Barrow, Susan, Little, Helen, Russell, David, Choudhary, Ulka, Haq, Ikram, Ainsworth, Paul, Jones, Claire, Weeks, Phil, Eden, Jane, Gibbons, Lisa, Glencross, Janet, MacLeod, Alison, Poland, K., Mulolland, Conor, Warke, A., Conn, Paul, Burns, D., Smith, R., Kamath, R., Webster, Jonathan, Hodgins, Ian, Vercoe, Stephen, Roome, Paul, Pinnock, Hilary, Patel, Jayesh, Ali, Amar, Hart, Nigel, Davies, Richard, De-Sousa, Nigel, Neden, Catherine, Danielsen, Mark, Sharma, Purnima, Galloway, Sophia, Hawkins, Charlotte, Oliver, Raife, Aylward, Martin, Pattni, Mira, Irvine, Gordon, Ahmad, Shahid, Rothwell, Catherine, Choudhary, Fiaz, Khalaque, Sabrina, Short, Stephanie, Peters, Sharon, Coulson, Warwick, Roberts, Neil, Coates, Steven, Ward, Ben, Jackson, Daniel, Walton, Steve, Shepherd, Diane, Wong, Toh, Boon, Mark, Deacon, Melanie, Cornelius, David, Davies, Sarah, Ben Frankel, Ben Frankel, Choi, Henry, Sumner, Jon, Myhill, Tim, Estifanos, Salah, Geatch, Diane, Wilkinson, Justin, Veale, Richard, Forshaw, Karen, Hirst, Rob, Zaman, Kashif, Liley, Catherine, Wastling, Rebecca, McEleny, Paul, Beattie, Andre, Cooke, Philip, Wong, Mike, Pugsley, Mark, Dooldeniya, Chaminda, Rogers, Greg, Bennett, James, Muvva, Rajesh, Adam, Matthew, Fox, Robin, Thomas, Nicolas, Cartwright, Simon, Reed, Rory, Randfield, Simon, ACourt, Christine, Flynn, Ann, Halpin, Andrew, Dobson, Simon, Lomax, Louise, Nadaph, Minnal, Goram, Jane, Stoddart, Helen, Simmons, Phil, Shewring, John, Bowen-Simpkins, Emma, Rickenbach, Mark, Munro, Iain, Blenkhorn, Adam, Singh, Bhuwanendu, van Gaal, William, Abhayaratna, Walter, Thomson, Philip, Lehman, Ron, Kilian, Jens, Coulshed, David, Camm, A. John, Fitzmaurice, David A., Illingworth, Laura, Kayani, Gloria, Kakkar, Ajay K., YILMAZ, MEHMET BİRHAN, Taga, Kuniaki, Techigawara, Masaaki, Igarashi, Mono, Watanabe, Hiroshi, Seo, Toshihiko, Hiramitsu, Shinya, Hosokawa, Hiroaki, Hoshiai, Mitsumoto, Hibino, Michitaka, Miyagawa, Koichi, Horie, Hideki, Turpie, Alexander G. G., van Eickels, Martin, Hacke, Werner, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Kayani, Glo-ria, Fox, Keith A. A., Gersh, Bernard J., Lucas Luciardi, Hector, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Pereira Barrett, Antonio Carlos, Connolly, Stuart J., Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Nielsen, JOrn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, Kakkar, Sanjay, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Koretsune, Yukihiro, Sanchez Diaz, Carlos Jerjes, Ten Cate, Hugo, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Vinolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Fitzmaurice, David, Chen, Kangning, Zhao, Yusheng, Zhang, Huaiqin, Chen, Jiyan, Cao, Shiping, Wang, Daowen, Yang, Yuejin, Li, Weihua, Li, Hui, Yin, Yuehui, Tao, Guizhou, Kothiwale, Veerappa Annasaheb, Kimura, Teruaki, Raghuraman, Bagirath, Vijan, Vinod Madan, Sawhney, Jitendra, Khan, Aziz, Meena, Ramdhan, Okuda, Fumio, Mizuguchi, Masato, Mukawa, Hiroaki, Chopada, Manojkumar, Abraham, Sunitha, Bisne, Vikas, Vijayaraghavan, Govindan, Roy, Debabrata, Durgaprasad, Rajashekhar, Shankar, A. G. Ravi, Kumar, Sunil, Jain, Dinesh, Bhargava, Kartikeya, Kumar, Vinay, Nagamalesh, Udigala Madappa, Rajput, Rajeeve Kumar, Kanamori, Seishu, Wada, Masamichi, Minagawa, Taro, Ishiguro, Motoyuki, Yamamoto, Kenichi, Kumagai, Koichiro, Katsuda, Yosuke, Yoshida, Keiki, Toyota, Fumitoshi, Mizuno, Yuji, Misumi, Ikuo, Noguchi, Hiroo, Ando, Shinichi, Suetsugu, Tetsuro, Minamoto, Masahiro, Oda, Hiroyuki, Adachi, Susumu, Chiba, Kei, Norita, Hiroaki, Tsuruta, Makoto, Koyanagi, Takeshi, Matsuta, Masahiro, Ito, Kenichiro, Nakano, Masayuki, Shibuya, Mitsuhiro, Stepinska, Janina, Jansky, Petr, Yamamoto, Kunihiko, Haas, Sylvia, Ando, Hiroshi, Higashi, Takayuki, Okada, Megumi, Azakami, Shiro, Komaki, Shinichiro, Kumeda, Kenshi, Murayama, Takashi, Matsumura, Jun, Oba, Yurika, Sonoda, Ryuji, Goto, Kazuo, Minoda, Kotaro, Haraguchi, Yoshikuni, Suefuji, Hisakazu, Miyagi, Hiroo, Kato, Hitoshi, Nakamura, Tsugihiro, Nakamura, Tadashi, Nandate, Hidekazu, Zaitsu, Ryuji, Fujiura, Yoshihisa, Yoshimura, Akira, Numata, Hiroyuki, Ogawa, Jun, Murakami, Kinshiro, Wakasa, Yutaka, Yamasawa, Masanori, Maekawa, Hiromitsu, Abe, Sumihisa, Kihara, Hajime, Tsunoda, Satoru, Saito, Katsumi, Tachibana, Hiroki, Oba, Ichiro, Kuwahata, Takashi, Higa, Satoshi, Gushiken, Masamichi, Eto, Takuma, Chibana, Hidetoshi, Fujisawa, Kazuaki, Shiga, Yuhei, Sumi, Hirokuni, Nagatomo, Toshihisa, Atsuchi, Yoshihiko, Nagoshi, Toshiro, Sanno, Kazuhisa, Hoshino, Fumihiro, Yokota, Naoto, Kameko, Masahiro, Tabuchi, Toshifumi, Ishizawa, Munesumi, Fujiura, Yoshitake, Ikeda, Daisuke, Seto, Taku, Iwao, Tetsu, Ishioka, Norio, Oshiro, Koichi, Tsuchida, Keizo, Hatori, Yutaka, Takeuchi, Motoshi, Takezawa, Hiroto, Kira, Tetsuya, Tada, Masato, Tsuzaki, Ken, Miura, Naoya, Fujisawa, Yasuaki, Furumoto, Wataru, Suzuki, Susumu, Fujisawa, Akinori, Nakamura, Ryosai, Komatsu, Hiroyasu, Fujiki, Rei, Kawano, Shuichi, Nishizawa, Keijiro, Kato, Yoji, Azuma, Junya, Yasui, Kiyoshi, Amano, Toshio, Sekine, Yasuhiro, Honzawa, Tatsuo, Koshibu, Yuichiro, Sakamoto, Yasuhide, Seta, Yukihiro, Miyaguchi, Shingo, Morishita, Kojuro, Samejima, Yasuko, Sasaki, Toyoshi, Iseki, Fumiko, Kobayashi, Toshiyuki, Kano, Hiroshi, Kim, Jaeyoung, Yamaguchi, Hiroshi, Takagi, Yoichi, Pearce, Yoko Onuki, Suzuki, Yasuyuki, Fukui, Takayuki, Nakayama, Toni, Kanai, Hideaki, Kawano, Yoshiyuki, Ino, Tetsuji, Miyoshi, Hironori, Miyamoto, Yasufumi, Shigekiyo, Masahito, Ono, Shimato, Okamoto, Yutaka, Ubukata, Satoshi, Kodera, Kojiro, Oriuchi, Tatsuo, Matsumoto, Naoki, Nagano, Shinjiro, Iwaki, Masaaki, Nakamura, Yuichiro, Miyamoto, Naomasa, Taguchi, Toshifumi, Ashida, Ko, Yoshizawa, Naoto, Agata, Jun, Matsukawa, Seishiro, Arasaki, Osamu, Fukuoka, Shuji, Murakami, Hirofumi, Mishima, Kazuya, Hata, Yoshiki, Sakuma, Ichiro, Obunai, Kotaro, Takamura, Ichiro, Akutsu, Mitsuyuki, Unoki, Toshihide, Go, Yoshinori, Ikemura, Makoto, Morii, Shoji, Marusaki, Shigem, Doi, Hideo, Tanaka, Mitsuru, Kusu-moto, Takaaki, Kakinoki, Shigeo, Ogurusu, Chiga, Murata, Kazuya, Shimoyama, Masaki, Nakatsuka, Masami, Kitami, Yutaka, Nakamura, Yoichi, Oda, Hiroshi, Oyama, Rikimaru, Ageta, Masato, Mita, Teruaki, Nagao, Kazuhiko, Mito, Takafumi, Minami, Junichi, Abe, Mitsunori, Fujii, Masako, Okawa, Makoto, Fujito, Tsuneo, Taniguchi, Toshiya, Ko, Tenei, Kubo, Hiroshi, Imamaki, Mizuho, Akiyama, Masahiro, Ueda, Takashi, Odakura, Hironori, Inagaki, Masahiko, Katsube, Yoshiki, Nakata, Atsuyuki, Tomimoto, Shinobu, Sugishita, Nobuyoshi, Shiga, Yukio, Soma, Akira, Neya, Kazuo, Yoshida, Tetsuro, Akahane, Kunio, Adachi, Sen, Takanaka, Chiei, Matsui, Saori, Kanda, Hirofumi, Kaneko, Masanori, Nagasaka, Shiro, Taguchi, Atsushi, Toru, Shuta, Saito, Kazuyuki, Miyashita, Akiko, Sasaguri, Hiroki, Nariyama, Jin, Hatsuno, Taketo, Iwase, Takash, Sato, Kazuki, Kawai, Kazuya, Kotani, Tomobumi, Tsuji, Tsuyoshi, Sakai, Hirosumi, Nishino, Kiyoshi, Ikeda, Kenichi, Maeda, Kazuo, Shinozuka, Tomohiro, Inoue, Takeshi, Kawakami, Koichi, Kitazumi, Hiromichi, Takagi, Tsutomu, Hamaoka, Mamoru, Kojima, Jisho, Sasaki, Akitoshi, Tsuchiya, Yoshihiro, Bet-suyaku, Tetsuo, Higuchi, Koji, Honda, Masaaki, Hasegawa, Koichi, Baba, Takao, Mineoi, Kazuaki, Koeda, Toshihiko, Hirasawa, Kunihiko, Kumazaki, Toshihide, Nakagomi, Akira, Otaki, Eiji, Shindo, Takashi, Hirayama, Hiroyoshi, Sugimoto, Chikako, Yamagishi, Takashi, Mizuguchi, Ichiro, Sezaki, Kazunori, Niwa, Isamu, Takenaka, Ken, Iiji, Osamu, Taya, Koichi, Kitazawa, Hitoshi, Ueda, Samu, Kakuda, Hirokazu, Ono, Takuya, Oriso, Seizo, Kamata, Junya, Nanke, Toshihiko, Maeda, Itaru, Matsuura, Yoshifusa, Teragawa, Hiroki, Maruyama, Yasuyuki, Takei, Kazuo, Hone, Hajime, Kito, Tetsu-taro, Asano, Hiroshi, Matsushita, Koji, Nakamura, Masaichi, Washizuka, Takashi, Yoshida, Tomoki, Sawano, Masato, Arima, Shinichi, Arai, Hidekazu, Shinohara, Hisanori, Takai, Hiroyuki, Furukawa, Nobufusa, Ota, Akira, Yamamoto, Kentaro, Aoki, Kenji, Yamamoto, Taku, Kasai, Takeaki, Suzuki, Shunji, Suzuki, Shu, Shibata, Nitaro, Watanabe, Masayuki, Nishihata, Yosuke, Arino, Torn, Okuyama, Masaki, Wakiyama, Tetsushi, Kato, Tomoko, Sasagawa, Yasuo, Tana, Takeshi, Tumelero, Rogerio Tadeu, Maia, Lilia, de Almeida, Roberto Simoes, Carmo Borges, Ney Carter, Gomes Ferreira, Luis Gustavo, Stockins Fernandez, Benjamin Aleck Joseh, Montecinos, Humberto, Lanas, Fernando, Larico Gomez, Martin, Astudillo, Carlos, Conejeros, Carlos, Marin Cuevas, Patricio, Forero, Alejandro, Bugueno Gutierrez, Claudio, Aguilar, Juan, Potthoff Cardenas, Sergio, Eggers, German, Houzvic, Cesar, Rey, Carlos, Arriagada, German, Charme Vilches, Gustavo, Illescas Diaz, Jesus Jaime, Leal Cantu, Raul, Ramos Zavala, Maria Guadalupe, Cabrera Jardines, Ricardo, Espinola Zavaleta, Nilda, Lopez Rosas, Enrique, Llamas Esperon, Guillermo Antonio, Pozas, Gerardo, Cardona Munoz, Ernesto, Her-nandez, Norberto Matadamas, Leyva Rendon, Adolfo, Garcia Hernandez, Norberto, de los Rios Ibarra, Manuel, Virgen Carrillo, Luis Ramon, Lopez Villezca, David, Hernandez Herrera, Carlos, Lopez Prieto, Juan Jose, Gaona Rodriguez, Rodolfo, Villeda Espinosa, Efrain, Flores Martinez, David, Velasco Barcena, Jose, Fierro Fierro, Omar, Rodriguez Briones, Ignacio, Leiva Pons, Jose Luis, Alvarez Lopez, Humberto, Olvera Ruiz, Rafael, Cantu Brito, Carlos Gerardo, Chuquiure Valenzuela, Eduardo Julian Jose Roberto, Reyes Sanchez, Roxana, Bazzoni Ruiz, Alberto Esteban, Lopez Ruiz, Oscar Martin, Arriaga Nava, Roberto, Morales Cerda, Jesus David, Fajardo Campos, Pedro, Benavides Gonzalez, Mario, Lenz, Kurt, Hagn, Claus, Foechterle, Johannes, Drexel, Heinz, Huber, Kurt, Podczeck-Schweighofer, Andrea, Winkler, Michael, Schneeweiss, Bruno, Gegenhuber, Alfons, Lang, Wilfried, Eichinger-Hasenauer, Sabine, Kaserer, Peter, Sykora, Josef, Rasch, Heribert, Strohmer, Bernhard, Capiau, Luc, Vervoort, Geert, Wollaert, Bart, Hollanders, Geert, Vercammen, Jan, Balthazar, Yohan, Delforge, Marc, Xhaet, Olivier, Striekwold, Harry, Thoeng, John, Hermans, Kurt, Mairesse, Georges, Anne, Wim, Blankoff, Ivan, Beutels, Michel, Vandergoten, Peter, Purnode, Philippe, Godart, Pascal, Boussy, Tim, Desfontaines, Philippe, Heyse, Alex, Voet, Joeri, De Wolf, Axel, Zidkova, Eva, Spacek, Rudolf, Machova, Vilma, Ludka, Ondrej, Olsr, Josef, Kotik, Lubos, Racz, Blazej, Ferkl, Richard, Hubac, Jan, Kotik, Ilja, Monhart, Zdenek, Burianova, Hana, Jerabek, Ondrej, Pisova, Jana, Petrova, Iveta, Dedek, Vratislav, Honkova, Michaela, Podrazil, Petr, Reichert, Petr, Spinar, Jindrich, Novak, Miroslav, Durdil, Vaclav, Plocova, Katarina, Lastuvka, Jiri, Nielsen, Jorn, Hayashi, Yoshihito, Hirota, Shinichi, Abe, Yukihiko, Saito, Yoshihiro, Uchiyama, Hirohide, Takeda, Hiroshi, Ono, Hiroshi, Tohyo, Shuichi, Hanazono, Naoto, Miyajima, Seiichi, Shimono, Hisashi, Aoyama, Takuma, Shozawa, Yasunobu, Niijima, Yawara, Murai, Osamu, Inaba, Hideko, Nomura, Katsumasa, Nozoe, Masatsugu, Suzuki, Kazuo, Furukawa, Toshiyuki, Shiraiwa, Toshihiko, Ito, Nobuhisa, Nagai, Shunichi, Sato, Kiyoharu, Nakahara, Shiro, Shimoyama, Yujin, Ohara, Naoko, Kozuka, Teruhiko, Okita, Hideaki, Endo, Masato, Goto, Tsutomu, Hirose, Makoto, Nagata, Emiko, Nakanishi, Noriyuki, Mori, Toshizumi, Seki, Shuichi, Okamoto, Katsuhiro, Moriai, Osamu, Emura, Yoko, Fukuda, Tsuyoshi, Date, Haruhiko, Kawakami, Shuichi, Nagai, Sho, Ueyama, Yuya, Fudo, Tetsuro, Imaizumi, Mitsuru, Ogawa, Takuo, Take, Shunsuke, Ikeda, Hideo, Nishioka, Hiroaki, Sakamoto, Norihiko, Ikeoka, Kiyomitsu, Wakaki, Nobuo, Abe, Masatake, Doiuchi, Junji, Inagaki, Koichi, Iseki, Atsushi, Yoshida, Tomohiro, Goda, Toshihiro, Katsuki, Tsukasa, Sato, Atsushi, Mori, Etsuo, Tsubokura, Toshio, Shudo, Hiroshi, Fujimoto, Shunichi, Katsuya, Tomohiro, Furukawa, Yoshiyuki, Hosokawa, Hiroshi, Narumi, Jun, Yamamoto, Kiichiro, Owari, Masaki, Inakura, Takuya, Anno, Takafumi, Shirakawa, Kazuyuki, Ching, Chi Keong, Foo, David, Wong, Kelvin, Yuyang, Tan, Park, Hui Nam, Kim, Woo-Shik, Lee, HyeYoung, Jang, Sung-Won, Kim, Dae Hyeok, Kim, Jun, Ryu, DongRyeol, Shim, Jaemin, Kim, Dae-Kyeong, Choi, Dong Ju, Oh, Yong Seog, Cho, Myeong-Chan, Kim, Hack-Lyoung, Jeon, Hui-Kyung, Shin, Dong-Gu, Park, Sang Weon, Park, Hoon Ki, Han, Sang-Jin, Sung, Jung Hoon, Park, Hyung-Wook, Nam, Gi-Byoung, On, Young Keun, Lim, Hong Euy, Kwak, JaeJin, Cha, Tae-Joon, Hong, Taek Jong, Park, Seong Hoon, Yoon, Jung Han, Kim, Nam-Ho, Kim, Kee-Sik, Jung, Byung Chun, Hwang, Gyo-Seung, Kim, Chong-Jin, Rungaramsin, Sakda, Katekangplu, Peerapat, Khunrong, Porames, Bunyapipat, Thanita, Wongcharoen, Wanwarang, Kaewsuwanna, Pinij, Siriwattana, Khanchai, Tiyanon, Waraporn, Pattanaprichakul, Supalerk, Likittanasombat, Khanchit, Cholsaringkarl, Doungrat, Boonyapisit, Warangkana, Cheewatanakornkul, Sirichai, Silaruks, Songkwan, Hutayanon, Pisit, Chawanadelert, Seksan, Chattranukulchai, Pairoj, Chatlaong, Boonsert, Santanakorn, Yingsak, Kanokphatcharakun, Khompiya, Mongkolwongroj, Piya, Jai-Aue, Sasivimon, Komson, Ongkarn, Altun, Armagan, Aydinlar, Ali, Ongen, Zeki, Acikel, Sadik, Sahin, Durmus Yildiray, Yilmaz, Ozcan, Pekdemir, Hasan, Demir, Mesut, Sucu, Murat, Sahiner, Levent, Ersanli, Murat, Okuyan, Ertugrul, Aras, Dursun, Rolandi, Florencia, Cesar Ingaramo, Adrian, Alberto Sambadaro, Gustavo, Fernandez Caputi, Vanina, Luciardi, Hector, Graciela Berman, Sofia, Dragotto, Pablo, Poli, Daniela, Quintavalla, Roberto, Cosmi, Franco, Fanelli, Raffaele, Oriana, Vincenzo, Reggio, Raffaele, Anti, Roberto S., Pancaldi, Leonardo, De Cristofaro, Raimondo, Guazzaloca, Giuliana, De Blasio, Angelo, Uriate, Jorge Salerno, Lillo, Flavia, Pogliani, Enrico Maria, Javier Kleiban, Andres, Ahuad Guerrero, Rodolfo Andres, Adalberto Di Paola, Leonel, Dario Dran, Ricardo, Egido, Javier, Jose Fosco, Matias, Rodolfo Cartasegna, Luis, Gomez Vilamajo, Oscar, Luis Ramos, Jose, Sassone, Sonia, Zapata, Gerardo, Conde, Diego, Giacomi, Guillermo, Alfredo Fernandez, Alberto, Alberto Berli, Mario, Ferroni, Fabian, Sobral Filho, Dario Celestino, Jaber, Jefferson, Armaganijan, Luciana Vidal, Frack Costantini, Costantino Roberto, Steffens, Andre, Sebba Barroso de Souzaem, Weimar Kunz, de Souza Neto, Joao David, Ribeiro, Jose Marcio, Teixeira, Marcelo Silveira, Rossi, Paulo, Pires, Leonardo, Moreira, Daniel, Moura Jorge, Jose Carlos, Lorga Filho, Adalberto Menezes, Bodanese, Luiz, Montera, Marcelo Westerlund, Del Carlo, Carlos Henrique, Saad, Jamil Abdalla, Alves Costa, Fernando Augusto, Lopes, Renato, de Aranjo, Gilson Roberto, Manenti, Euler Roberto, Kerr Saraiva, Jose Francisco, Ferreira Braga, Joao Carlos, Negri, Alexandre, Moncada, Carlos, Precoma, Dalton, Roquette, Fernando, Reis, Gilmar, Ramos Filho, Roberto Alvaro, Figueiredo, Estevao Lanna, Botelho, Roberto Vieira, Fontoura Tavares, Claudio Munhoz, Finimundi, Helius Carlos, Kochi, Adriano, Broilo Franca, Cesar Cassio, Alban, Fabio, Aranha Rosito, Guido Bernardo, de Moura Xavier Moraes Junior, Joao Batista, Husted, Steen, Hintze, Ulrik, Rasmussen, Soren, Sygehus, Nwstved, Bremmelgaard, Arne, Markenvard, John, Borger, Jan, Solgaard, Jorgen, Eriksen, Ebbe, Lokkegaard, Thomas, Bruun, Michael, Mertz, Jacob, Schou, Morten, Olsen, Michael, Viitanen, Carmela, Paganelli, Franck, Ohayon, Joel, Casassus, Frederic, Galinier, Michel, Gottwalles, Yannick, Loiselet, Philippe, Koujan, Mohamed Bassel, Destrac, Sylvain, Piot, Olivier, Cebron, Jean-Pierre, Guenoun, Maxime, Guedj-Meynier, Dominique, Lokesh, A. G., Zuber, Mathieu, Amarenco, Pierre, Ellie, Emmanuel, Kadouch, James, Huberman, Jean-Pierre, Lemaire, Nestor, Rodier, Gilles, Vandamme, Xavier, Sibon, Igor, Neau, Jean-Philippe, Mahagne, Marie Helene, Mielot, Antoine, Bonnefoy, Marc, Churet, Jean-Baptiste, Navarre, Vincent, Sellem, Frederic, Monniot, Gilles, Boyes, Jean-Paul, Doucet, Bernard, Martelet, Michel, Obadia, Desire, Crousillat, Bernard, Mouallem, Joseph, Bearez, Etienne, Brugnaux, Jean Philippe, Fedorowsky, Alain, Nazeyrollas, Pierre, Berneau, Jean-Baptiste, Chemin, Frederic, Schellong, Sebastien, Koeniger, Georg, Kopf, Andreas, Gerbaulet, Uwe, Kellner, Bernd-Thomas, Schaefer, Thomas, Purr, Jan, Eissfeller, Enno, Zauzig, Heinz-Dieter, Riegel, Peter, Axthelm, Christoph, Heinz, Gerd-Ulrich, Pustelnik, Andreas, Zutz, Stefan, Eder, Wolfgang, Rehling, Guenter, Glatzel, Dirk, Ludwig, Norbert, Sandow, Petra, Wiswedel, Henning, Wildenauer, Cosmas, Schoen, Steffen, Schwarz, Toralf, Babyesiza, Adyeri, Kropp, Maximilian, Zimny, Hans-Hermann, Kahl, Friedhelm, Caspar, Andreas, Omankowsky, Sabine, Laessig, Torsten, Hartmann, Hermann-Josef, Lehmann, Gunter, Bindig, Hans-Walter, Hergdt, Gunter, Reimer, Dietrich, Hauk, Joachim, Michel, Holger, Dres, Praxis, Erdle, Werner, Dorsch, Wilfried, Dshabrailov, Janna, Rapp, Karl-Albrecht, Epelde Gonzalo, Francisco, Almeida Fernandez, Carlos Alexandre, Martinez Navarro, Encarnacion, Montero Alia, Juan Jose, Barreda Gonzalez, Maria, Moleiro Oliva, Maria Angels, Iglesias Sanmartin, Jose, Rodriguez Alvarez, Maria del Mar, Ripoll Vera, Tomas, Jimenez Navarro, Manuel, Vazquez Caamano, Maria, Arcocha Tones, Maria Fe, Marcos Gomez, Gonzalo, Iniguez Romo, Andres, Prieto Diaz, Miguel Angel, Wirdby, Alexander, Linden, Jan, and Henriksson, Kerstin
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Male ,medicine.medical_specialty ,Acute coronary syndrome ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Hemorrhage ,030204 cardiovascular system & hematology ,antiplatelet therapy ,Coronary artery disease ,Anticoagulation ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Cause of Death ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,030212 general & internal medicine ,Acute Coronary Syndrome ,bleeding ,mortality ,stroke ,Stroke ,Aged ,Proportional Hazards Models ,business.industry ,Hazard ratio ,Anticoagulants ,Atrial fibrillation ,General Medicine ,Prognosis ,medicine.disease ,Blood pressure ,Cardiovascular Diseases ,Heart failure ,Cardiology ,Female ,Liver function ,business ,Platelet Aggregation Inhibitors ,Follow-Up Studies - Abstract
Item does not contain fulltext BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes. METHODS: Adults with newly diagnosed atrial fibrillation and >/=1 investigator-defined stroke risk factor were enrolled in GARFIELD-AF between March 2010 and September 2015. The association between prior acute coronary syndromes and long-term outcomes was determined using a Cox proportional hazards model, adjusting for baseline risk factors, oral anticoagulation (OAC) +/- antiplatelet (AP) therapy, and usual care. RESULTS: Of 39,679 patients, 10.5% had a history of acute coronary syndromes. At 2-year follow-up, patients with prior acute coronary syndromes had higher adjusted risks of stroke/systemic embolism (hazard ratio [HR] 1.39; 95% confidence interval [CI], 1.08-1.78), major bleeding (HR 1.30; 95% CI, 0.95 -1.79), all-cause mortality (HR 1.34; 95% CI, 1.21 -1.49), cardiovascular mortality (HR 1.85; 95% CI, 1.51-2.26), and new acute coronary syndromes (HR 3.42; 95% CI, 2.62-4.45). Comparing antithrombotic therapy in the acute coronary syndromes vs no acute coronary syndromes groups, most patients received OAC +/- AP: 60.8% vs 66.1%, but AP therapy was more likely in the acute coronary syndromes group (68.1% vs 32.9%), either alone (34.9% vs 20.8%) or with OAC (33.2% vs 12.1%). Overall, 17.8% in the acute coronary syndromes group received dual AP therapy with (5.3%) or without OAC (12.5%). Among patients with moderate/high risk for stroke/systemic embolism, fewer in the acute coronary syndromes group received OAC with or without AP therapy (Congestive heart failure, Hypertension, Age 75 years, Diabetes mellitus, prior Stroke, TIA, or thromboembolism, Vascular disease, Age 65-74 years, Sex category [CHA2DS2-VASc] 2: 52.1% vs 64.6%; CHA2DS2-VASc >/=3: 62.0% vs 70.7%), and the majority with a Hypertension (uncontrolled systolic blood pressure >160 mm Hg), Abnormal renal or liver function, previous Stroke, Bleeding history or predisposition, Labile international normalized ratios, Elderly, and concomitant Drugs or alcohol excess (HAS-BLED) score >/=3 were on AP therapy (83.8% vs 65.5%). CONCLUSIONS: In GARFIELD-AF, previous acute coronary syndromes are associated with worse 2-year outcomes and a greater likelihood of under-treatment with OAC, while two-thirds of patients receive AP therapy. Major bleeding was more common with previous acute coronary syndromes, even after adjusting for all risk factors.
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- 2019
18. Hyponatremia in patients with chronic heart failure and preserved ejection fraction of the left ventricle
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Lazidi, Ekaterina, Rudyk, Iurii, Visotska, Olena, Pecherska, Anna, and Bolotskykh, Ganna
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хроническая сердечная недостаточность ,сохраненная фракция выброса ,гипонатриемия ,клиническое и прогностическое значение ,chronic heart failure ,preserved ejection fraction ,hyponatremia ,clinical and prognostic value ,УДК:616.12-008.46-036.12-02:612.392.61 - Abstract
Aim of the study: to study the occurrence of hyponatremia in patients with chronic heart failure (CHF) with LVPEF.Material and methods: The study multi-directionally included 361 patients with CHF and LVPEF, who were at stationary treatment in the clinic SI “National institute of therapy, named after L.T. Malaya, NAMS of Ukraine”. All patients were divided in 3 groups: Group 1 – 120 patients with the stable course of the disease. Group 2 –163 patients with decompensation of CHF in LVPEF. Group 3 included 78 patients with HF and LVPEF, died as a result of HF acute decompensation. The obtained results were processed using the package of applied statistic programs SPSS 17.0.Results of the study: In group 1 6 patients (5.0 %) demonstrated hyponatremia. In group 2 it was detected in 42 patients (25.8 %), in 3 group – in 30 persons (38.0 %). Hyponatremia occurs more often in patients with CHF and LVPEF older than 60 years (75.6±4.9 %) comparing with younger patients (24.4±4.9 %, p, Целью исследования было изучить встречаемость гипонатриемии у пациентов с хронической сердечной недостаточностью (ХСН) и СФВЛЖ. Результаты исследования показали, что гипонатриемия чаще ассоциируется с более тяжелым течением заболевания и неблагоприятным исходом у больных с сердечной недостаточностью (СН) и сохраненной фракцией выброса левого желудочка (СФВЛЖ)
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- 2018
19. Overview of the impact β1-adrenergic receptor gene polymorphisms have on the progression of heart failure
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Rudyk, Iurii, primary, Pyvovar, Serhii, additional, Lozyk, Tetiana, additional, and Bondar, Tetiana, additional
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- 2019
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20. Clinical and biochemical predictors of unfavorable prognosis for heart failure with preserved ejection fraction and type 2 diabetes mellitus
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Rudyk, Iurii S., primary, Bolotskykh, Ganna V., additional, and Udovychenko, Maryna M., additional
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- 2015
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21. TNFa and Serum Galectin-3 in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction, Insulin Resistance and Type 2 Diabetes Mellitus
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Bolotskykh, Ganna, primary and Rudyk, Iurii, additional
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- 2014
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22. Promising Role of Vascular Endothelial Growth Factor-A in Risk Stratification after PCI
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Petyunina, Olga V, Kopytsya, Mykola, Rudyk, Iurii, and Isayeva, Ganna
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Medical - Abstract
Vascular endothelial growth factor-A (VEGF-A), dimeric glycoprotein, is a potent endothelial cell-specific mitogen which plays a key role in angiogenesis, especially in response to ischemia. Biomarkers reflect various pathophysiological faces of spherical LV transformation that related to myocardial stress due to persisted ischemia, fibrosis, and inflammation, and they may be helpful to improve risk stratification, more personalized medical approach for creating of individual medical care for HF preventing and adjusted treatment after STEMI. VEGF-A decrease ≤172.4 pg./ml on the 7th day of STEMI allows to prognose after infarction angina after 6-month observation (area under curve (AUC) 0.697, with sensitivity 88.9% and specificity 50.9%; 95% CI 0.567–0.807, P = 0.0515). Anxiety and depression 10–14 days before MI associated with VEGF-A level decrease (anxiety (Taylor): OR 0.834, 95% CІ 0.726–0.959, Р = 0.0107; depression (HADS): OR 0.741, 95% CІ 0.535–1.027, Р = 0.0519. Cut-off VEGF-A level ≤201.86 pg./ml on the 7th day of STEMI (AUC 0.711, sensitivity 85.7% and specificity 57.9%; 95% CІ 0.513–0.908, Р = 0.036) was effective for prognosis of dysadaptive left ventricular remodeling in STEMI patients after 6-month observation period. These findings may open new approach to stratify patients with successful coronary revascularization at risk of HF.
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- 2020
23. Use of beta-blockers in patients with heart failure - unresolved issues.
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Pyvovar SM and Rudyk IS
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- Adrenergic beta-Antagonists therapeutic use, Humans, Stroke Volume, Heart Failure complications, Heart Failure drug therapy, Ventricular Function, Left
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The analysis of literature data reflecting the issues of the mechanisms of action of beta-blockers in patients with heart failure are present. The heart failure has many variants. With each of these options, the concentration of catecholamines and the sensitivity of beta receptors change differently. The effectiveness of beta-blockers also differs in this. The beta-adrenergic receptors genes polymorphisms also affect the efficacy and safety of beta-blockers. The comorbidities also affect to the action and efficacy of beta-blockers in patients with heart failure. When using beta-blockers in patients with heart failure, there are still many unresolved questions: What is the best reference point for titration of drugs - dose or heart rate; what effects do these drugs have in heart failure with a preserved left ventricular ejection fraction? How do beta-blockers affect the course of heart failure in patients with comorbid thyroid pathology, taking into account their pharmacological properties and their effect on the activity of peripheral deidinases?, (© 2022 MEDPRESS.)
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- 2022
24. Influence of various risk factors on the level of ST2 biomarker in patients with heart failure and diabetes mellitus type 2.
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Rudyk IS, Medentseva OO, Gasanov IC, and Babichev DP
- Subjects
- Biomarkers, Female, Humans, Male, Risk Factors, Stroke Volume, Diabetes Mellitus, Type 2 complications, Heart Failure
- Abstract
Heart failure (HF) despite the progress in treatment remains the main health problem worldwide. Biomarker ST2 is currently being studied in patients with HF due to its high potential predictive value and promising prospects for use as a component of biomarker-controlled therapy. The factors that can impact on the ST2 biomarker level in diabetic patients with heart failure with preserved ejection fraction (HFpEF) are still not well known., Aim: The aim of the study was to determine the influence of various risk factors on ST2 levels in patients with HFpEF and diabetes mellitus type 2 (T2DM)., Materials and Methods: A total of one hundred and thirty-four patients (74 females and 60 males, 51 diabetic patients and 83 patients without T2DM with HFpEF were examined. Duration of HF and T2DM, common risk factors, such as smoking, overweight, clinical examination, parameters of carbohydrate and lipid metabolism, glomerular filtration rate (GFR) and M235T polymorphism of ATG have been used. Multivariate backward stepwise cox regression analysis was performed in Statistica 10,0. p<0,05 was considered statistically significant., Results: ST2 level in patients with HFpEF associated with T2DM exceeded this value in patients with HFpEF without T2DM and was 23.26 ng/ml (18.5: 29.3) vs. 20.39 ng/ml (18.3: 24.6), respectively (p<0,05). To assess the cumulative effect of the studied factors on the ST2 level, we performed the Cox's stepwise multivariate regression analysis. Smoking, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), glucose, HbA1 and insulin levels were found to be the most significant factors influencing ST2 levels in patients with HF and T2DM, indicating a significant effect of DM type 2 on ST2 concentration., Conclusions: Smoking, HOMA-IR, glucose, HbA1, and insulin levels can significantly affect ST2 levels in patients with T2DM and HFpEF., (© 2021 MEDPRESS.)
- Published
- 2021
25. The association of polymorphisms of β-adrenergic receptors genes with the low triiodothyronine syndrome in patients with a heart failure.
- Author
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Pyvovar SM, Rudyk IS, Kopytsya MP, Lozyk TV, Galchinskaya VY, and Bondar TM
- Subjects
- Genotype, Humans, Polymorphism, Genetic, Receptors, Adrenergic, beta-2, Triiodothyronine, Euthyroid Sick Syndromes genetics, Heart Failure genetics
- Abstract
The course of heart failure (HF) and its progression is associated with comorbidities, genetic factors and a dynamics of a number of biomarkers. The low triiodothyronine syndrome (LT3S) is observed in some patients with HF. Extremely little data are available in the literature regarding the effect of β-adrenoreceptors (β-AR) genes polymorphisms on the development of LT3S and many contradictory results about their association with HF course. This encourages new research in this area., Aim: The aim of study was to evaluate the relationship of β-adrenergic receptors gene polymorphisms with low triiodothyronine syndrome in patients with a heart failure., Materials and Methods: 354 patients with HF on a background of postinfarction cardiosclerosis were included to the study. At 89 (25.1%) patients LT3S was diagnosed. The course of HF was studied for 2 years. Mean levels of thyroid stimulating hormone (TSH), free T3f and T4f were evaluated. Genotyping of 4 single nucleotide polymorphisms (Gly389Arg of β1-AR gene, Ser49Gly of β1-AR gene, Gln27Glu of β2- AR gene and Ser275 of GNβ3 gene) was performed by polymerase chain reaction. Genetic and epidemiological analysis was performed using the SNPStats program., Results: The risk of LT3S in patients with HF increases with homozygous G/G variant of Gln27Glu polymorphism of the β2-AR gene (OR=2.21, p=0.037), described as a recessive model of inheritance. There was a tendency to increase the risk of LT3S development in the presence of the genotype C/T of the Ser275 polymorphism of the GNb3 gene (OR=1.75, p=0.054), described as an over-dominant model. The genotype C/G of the Gln27Glu polymorphism of the β2-AR gene was associated with a decreased risk of LT3S development (OR=0.54, p=0.037), described as over-dominant model. Patients with HF carriers the A allele (A/GA/A) of the Ser49Gly polymorphism of the β1-AR gene have a lower risk of repeated hospitalization due to HF decompensation (OR=0.50, p=0.032), described as a dominant model. There was a tendency to increase the risk of re-hospitalization in the G-allele (C/GG/ G) variant of the Gln27Glu polymorphism of the β2-AR gene (OR=1.68, p=0.057), described as a dominant heredity model. At patients with HF in combination with LT3S the risk of re-hospitalization increases at C/G variant of the Gln27Glu polymorphism of β2-AR gene (OR=1.25, p=0.025), described as an over-dominant model., Conclusions: The results suggest that congenital genetic alterations in β-adrenergic pathways may be associated with the development of LT3S in patients with HF and the features of the HF course., (© 2019 MEDPRESS.)
- Published
- 2019
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