1. A Meta-Analysis of Gut Microbiota in Children with Autism
- Author
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Andreo-Martínez, Pedro, Rubio-Aparicio, María, Sánchez-Meca, Julio, Veas, Alejandro, and Martínez-González, Agustín Ernesto
- Abstract
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of "Streptococcus" (SMD[subscript +] = -0.999; 95% CI -1.549, -0.449) and "Bifidobacterium" genera (SMD[subscript +] = -0.513; 95% CI -0.953, -0.073) in children with ASD. Overall, the "Bifidobacterium" genera is involved. However, differences found between studies are attributed to factors such as reporting bias.
- Published
- 2022
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