Search

Your search keyword '"Rubio, Jaime"' showing total 249 results
Start Over Author "Rubio, Jaime"
249 results on '"Rubio, Jaime"'

3. Dominant induction of the inflammasome by the SARS-CoV-2 accessory protein ORF9b, abrogated by small-molecule ORF9b homodimerization inhibitors

Author

Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, CSIC - Plataforma Temática Interdisciplinar del CSIC Salud Global (PTI Salud Global), European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Zodda, Erika [0000-0002-4536-9106], Pons, Mònica [0000-0002-3393-2782], De Moya, Nàtalia [0000-0002-7394-7030], Dies López-Ayllón, Blanca [0000-0003-3889-3644], Cascante, Marta [0000-0002-2062-4633], Montoya, María [0000-0002-5703-7360], Pujol, Maria Dolors [0000-0003-1061-034X], Rubio, Jaime [0000-0002-5529-2325], Thomson, Timothy M. [0000-0002-4670-9440], Zodda, Erika, Pons, Mònica, De Moya, Nàtalia, Calvo, Cristina, Benitez, Cristina, Dies López-Ayllón, Blanca, Hibot, Achraf, Cascante, Marta, Montoya, María, Pujol, Maria Dolors, Rubio, Jaime, Thomson, Timothy M., Consejo Superior de Investigaciones Científicas (España), Generalitat de Catalunya, CSIC - Plataforma Temática Interdisciplinar del CSIC Salud Global (PTI Salud Global), European Commission, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Zodda, Erika [0000-0002-4536-9106], Pons, Mònica [0000-0002-3393-2782], De Moya, Nàtalia [0000-0002-7394-7030], Dies López-Ayllón, Blanca [0000-0003-3889-3644], Cascante, Marta [0000-0002-2062-4633], Montoya, María [0000-0002-5703-7360], Pujol, Maria Dolors [0000-0003-1061-034X], Rubio, Jaime [0000-0002-5529-2325], Thomson, Timothy M. [0000-0002-4670-9440], Zodda, Erika, Pons, Mònica, De Moya, Nàtalia, Calvo, Cristina, Benitez, Cristina, Dies López-Ayllón, Blanca, Hibot, Achraf, Cascante, Marta, Montoya, María, Pujol, Maria Dolors, Rubio, Jaime, and Thomson, Timothy M.

Abstract

Viral accessory proteins play critical roles in viral escape form host innate immune responses and in viral inflammatory pathogenesis. Here we show that the SARS-CoV-2 accessory protein, ORF9b, but not other SARS-CoV-2 accessory proteins (ORF3a, ORF3b, ORF6, ORF7, ORF8, ORF9c, ORF10), strongly activates inflammasomedependent caspase-1 in A549 lung carcinoma cells and THP-1 monocyte-macrophage cells. Exposure to lipopolysaccharide (LPS) and ATP additively enhanced the activation of caspase-1 by ORF9b, suggesting that ORF9b and LPS follow parallel pathways in the activation of the inflammasome and caspase-1. Following rational in silico approaches, we have designed small molecules capable of inhibiting the homodimerization of ORF9b, which experimentally inhibited ORF9b-ORF9b homotypic interactions, caused mitochondrial eviction of ORF9b, inhibited ORF9b-induced activation of caspase-1 in A549 and THP-1 cells, cytokine release in THP-1 cells, and restored type I interferon (IFN-I) signaling suppressed by ORF9b in both cell models. These small molecules are first-in-class compounds targeting a viral accessory protein critical for viral-induced exacerbated inflammation and escape from innate immune responses, with the potential of mitigating the severe immunopathogenic damage induced by highly pathogenic coronaviruses and restoring antiviral innate immune responses curtailed by viral infection.

Published
2024

9. Modifications in self-care, quality of life and therapeutic adherence in patients with rheumatoid arthritis during the SARS-CoV-2 pandemic treated by telehealth

Author

Hernández-Zambrano, Sandra Milena, Castiblanco-Montañez, Ruth-Alexandra, Valencia Serna, Angie Marcela, Nonzoque Toro, Valentina, Sánchez Camargo, Maria Paula, Restrepo Rodríguez, Leidy Natalia, Rodríguez-Vargas, Gabriel-Santiago, Villareal, Laura, Rubio-Rubio, Jaime-Andrés, Quintero-Muñoz, Elías, Gómez Pineda, María Alejandra, Chávez-Chavéz, Josefina, Rivera-Triana, Diana, Casanova, Rosangela, Rojas-Villarraga, Adriana, and Santos-Moreno, Pedro

Published
2022
Full Text
View/download PDF

10. Inflammasome activation by SARS-CoV-2 accessory protein: Development of novel inhibitors of the SARS-CoV-2 accessory protein ORF9b

Author

Zodda, Erika [0000-0002-4536-9106], Dies López-Ayllón, Blanca [0000-0003-3889-3644], Calvo, Cristina [0000-0002-6503-3423], Benitez, Cristina [0000-0002-7981-1978], Cascante, Marta [0000-0002-2062-4633], Montoya, María [0000-0002-5703-7360], Pujol, Maria Dolors [0000-0003-1061-034X], Rubio, Jaime [0000-0002-5529-2325], Thomson, Timothy M. [0000-0002-4670-9440], Zodda, Erika, Pons, Mònica, De Moya, Nàtalia, Hibot, Achraf, Dies López-Ayllón, Blanca, Calvo, Cristina, Benitez, Cristina, Cascante, Marta, Montoya, María, Pujol, Maria Dolors, Rubio, Jaime, Thomson, Timothy M., Zodda, Erika [0000-0002-4536-9106], Dies López-Ayllón, Blanca [0000-0003-3889-3644], Calvo, Cristina [0000-0002-6503-3423], Benitez, Cristina [0000-0002-7981-1978], Cascante, Marta [0000-0002-2062-4633], Montoya, María [0000-0002-5703-7360], Pujol, Maria Dolors [0000-0003-1061-034X], Rubio, Jaime [0000-0002-5529-2325], Thomson, Timothy M. [0000-0002-4670-9440], Zodda, Erika, Pons, Mònica, De Moya, Nàtalia, Hibot, Achraf, Dies López-Ayllón, Blanca, Calvo, Cristina, Benitez, Cristina, Cascante, Marta, Montoya, María, Pujol, Maria Dolors, Rubio, Jaime, and Thomson, Timothy M.

Abstract

SARS-CoV-2 can activate the inflammasome, which, when unbridled, contributes to pathogenic inflammatory responses and to severe COVID-19. Several SARS-CoV-2 components have been shown to participate in this activation. Here, we have systematically assayed SARS-CoV-2 accessory proteins (ORF3a, ORF3b, ORF6, ORF7,ORF8, ORF9b, ORF9c and ORF10) for their ability to modulate inflammasome activity. We have found that among all accessory proteins, only ORF9b, a protein that locates in mitochondria, triggers a strong activation of caspase-1 activity and cytokine release in A549 lung epithelial cells and THP-1 monocyte-macrophage cells. This induction is observed both by transducing ORF9b alone or upon concomitant transduction of all accessory proteins. Based on the solved structure of ORF9b, we have conducted an in silico drug discovery effort to identify small molecules capable of disrupting the ORF9b homodimer and to attenuate its observed activity. Iterative steps of blind massive docking and molecular dynamics led to the identification of small molecules predicted to prevent ORF9b homodimeric interactions. This prediction was experimentally validated by means of surface plasmon resonance, yielding two active molecules. These molecules showed a potent inhibition of ORF9b-induced caspase-1 activation and cytokine release, and caused a remarkable eviction of ORF9b from mitochondria. These novel first-in-class ORF9b inhibitors are currently being tested for their ability to mitigate viral cytopathogenic effects.

Published
2023

11. Actionable mutational profiling in solid tumors using hybrid‐capture‐based next‐generation sequencing in a real‐world setting in Spain.

Author

Zazo, Sandra, Pérez‐Buira, Sandra, Carvajal, Nerea, Plaza‐Sánchez, Jenifer, Manso, Rebeca, Pérez‐González, Nuria, Dominguez, Carolina, Prieto‐Potin, Iván, Rubio, Jaime, Dómine, Manuel, Lozano, Virginia, Mohedano, Patricia, Carcedo, David, Carias, Rafael, and Rojo, Federico

Subjects
NUCLEOTIDE sequencing, SINGLE nucleotide polymorphisms, LUNG tumors, TUMORS, GASTROINTESTINAL stromal tumors
Abstract

Objective: This study aimed to describe the performance of a next‐generation sequencing (NGS) panel for the detection of precise genomic alterations in cancer in Spanish clinical practice. The impact of tumor characteristics was evaluated on informative NGS and actionable mutation rates. Materials and Methods: A cross‐sectional study was conducted at the Fundación Jiménez Díaz University Hospital (May 2021–March 2022) where molecular diagnostic of 537 Formalin‐Fixed Paraffin‐Embedded (FFPE) tissue samples of diverse solid tumors (lung, colorectal, melanoma, gastrointestinal stromal, among others) was performed using AVENIO Tumor Tissue Targeted Kit. A descriptive analysis of the features of all samples was carried out. Multivariable logistic analysis was conducted to assess the impact of sample characteristics on NGS performance defined by informative results rate (for all tumors and for lung tumors), and on actionable mutations rate (for lung tumors only). Results: AVENIO performance rate was 75.2% in all tumor samples and 75.3% in lung cancer samples, and the multivariable analysis showed that surgical specimens are most likely to provide informative results than diagnostic biopsies. Regarding the mutational findings, 727 pathogenic, likely pathogenic, or variant of unknown significance mutations were found in all tumor samples. Single nucleotide variant was the most common genomic alteration, both for all tumor samples (85.3% and 81.9% for all solid tumors and lung samples, respectively). In lung tumors, multivariable analysis showed that it is more likely to find actionable mutations from non‐smokers and patients with adenocarcinoma, large cell, or undifferentiated histologies. Conclusion: This is the largest cohort‐level study in Spain to profile the analyses of biopsy samples of different tumors using NGS in routine clinical practice. Our findings showed that the use of NGS routinely provides good rates of informative results and can improve tumor characterization and identify a greater number of actionable mutations. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. El acceso al recurso de suplicación en pleitos de modificación sustancial de condiciones de trabajo. Nueva doctrina unificadora de la Sala Cuarta del Supremo.

Author

DE LAMO RUBIO, JAIME

Subjects
DAMAGES (Law), APPELLATE courts, EURO, CONSTITUTIONAL courts, COURTS
Abstract

Copyright of Revista Crítica de Relaciones de Trabajo, Laborum is the property of Ediciones Laborum S.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

14. Modifications in self-care, quality of life and therapeutic adherence in patients with rheumatoid arthritis during the SARS-CoV-2 pandemic treated by telehealth

Author

Hernández-Zambrano, Sandra Milena, primary, Castiblanco-Montañez, Ruth-Alexandra, additional, Valencia Serna, Angie Marcela, additional, Nonzoque Toro, Valentina, additional, Sánchez Camargo, Maria Paula, additional, Restrepo Rodríguez, Leidy Natalia, additional, Rodríguez-Vargas, Gabriel-Santiago, additional, Villareal, Laura, additional, Rubio-Rubio, Jaime-Andrés, additional, Quintero-Muñoz, Elías, additional, Gómez Pineda, María Alejandra, additional, Chávez-Chavéz, Josefina, additional, Rivera-Triana, Diana, additional, Casanova, Rosangela, additional, Rojas-Villarraga, Adriana, additional, and Santos-Moreno, Pedro, additional

Published
2023
Full Text
View/download PDF

17. Modificaciones en el autocuidado, calidad de vida y adherencia terapéutica en pacientes con artritis reumatoide durante la pandemia por SARS-CoV-2 atendidos por telesalud

Author

Hernández-Zambrano, Sandra Milena, primary, Castiblanco-Montañez, Ruth-Alexandra, additional, Valencia Serna, Angie Marcela, additional, Nonzoque Toro, Valentina, additional, Sánchez Camargo, Maria Paula, additional, Restrepo Rodríguez, Leidy Natalia, additional, Rodríguez-Vargas, Gabriel-Santiago, additional, Villareal, Laura, additional, Rubio-Rubio, Jaime-Andrés, additional, Quintero-Muñoz, Elías, additional, Gómez Pineda, María Alejandra, additional, Chávez-Chavéz, Josefina, additional, Rivera-Triana, Diana, additional, Casanova, Rosangela, additional, Rojas-Villarraga, Adriana, additional, and Santos-Moreno, Pedro, additional

Published
2022
Full Text
View/download PDF

18. Human Perception in Segmentation of Sketches

Author

Company, Pedro, Varley, Peter A. C., Piquer, Ana, Vergara, Margarita, Sánchez-Rubio, Jaime, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ogier, Jean-Marc, editor, Liu, Wenyin, editor, and Lladós, Josep, editor

Published
2010
Full Text
View/download PDF

19. Vascular Age, Metabolic Panel, Cardiovascular Risk and Inflammaging in Patients With Rheumatoid Arthritis Compared With Patients With Osteoarthritis

Author

Rodríguez-Vargas, Gabriel-Santiago, primary, Santos-Moreno, Pedro, additional, Rubio-Rubio, Jaime-Andrés, additional, Bautista-Niño, Paula-Katherine, additional, Echeverri, Darío, additional, Gutiérrez-Castañeda, Luz-Dary, additional, Sierra-Matamoros, Fabio, additional, Navarrete, Stephania, additional, Aparicio, Anggie, additional, Saenz, Luis, additional, and Rojas-Villarraga, Adriana, additional

Published
2022
Full Text
View/download PDF

20. Artritis reumatoide y telemedicina en tiempos de COVID-19

Author

Rodríguez-Vargas, Gabriel Santiago, Nieto-Zambrano, Paula Daniela, Rubio-Rubio, Jaime Andrés, Santos-Moreno, Pedro, and Rojas-Villarraga, Adriana

Subjects
Chronic diseases, Enfermedades crónicas, Telemedicina, Artritis reumatoide, Rheumatoid arthritis, Sars-Cov2, Telemedicine
Published
2022

22. MicroRNA-199b Deregulation Shows Oncogenic Properties and Promising Clinical Value as Circulating Marker in Locally Advanced Rectal Cancer Patients

Author

Santos, Andrea, primary, Cristóbal, Ion, additional, Rubio, Jaime, additional, Caramés, Cristina, additional, Luque, Melani, additional, Sanz-Alvarez, Marta, additional, Morales-Gallego, Miriam, additional, Madoz-Gúrpide, Juan, additional, Rojo, Federico, additional, and García-Foncillas, Jesús, additional

Published
2022
Full Text
View/download PDF

23. Evaluation of a Non-Face-to-Face Multidisciplinary Health Care Model in a Population with Rheumatoid Arthritis Vulnerable to COVID-19 in a Health Emergency Situation

Author

Santos-Moreno, Pedro, primary, Rodríguez-Vargas, Gabriel-Santiago, additional, Casanova, Rosangela, additional, Rubio-Rubio, Jaime-Andrés, additional, Chávez-Chávez, Josefina, additional, Rivera-Triana, Diana, additional, Castiblanco-Montañez, Ruth, additional, Hernández-Zambrano, Sandra, additional, Villareal, Laura, additional, and Rojas-Villarraga, Adriana, additional

Published
2021
Full Text
View/download PDF

25. Ausencia de videograbación o de acta del juicio y nulidad de actuaciones judiciales (a propósito de la STS [Social] de 10 de enero de 2023).

Author

DE LAMO RUBIO, JAIME

Subjects
JUSTICE administration, SPANISH language, OFFICES, COMPUTER systems, APPELLATE courts, CONSTITUTIONAL courts
Abstract

Copyright of Revista Crítica de Relaciones de Trabajo, Laborum is the property of Ediciones Laborum S.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

26. Validation of microRNA-199b as A Promising Predictor of Outcome and Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer Patients

Author

Cristóbal, Ion, primary, Santos, Andrea, additional, Rubio, Jaime, additional, Caramés, Cristina, additional, Zazo, Sandra, additional, Sanz-Álvarez, Marta, additional, Luque, Melani, additional, Madoz-Gúrpide, Juan, additional, Rojo, Federico, additional, and García-Foncillas, Jesús, additional

Published
2021
Full Text
View/download PDF

27. Desarrollo de un medidor de bajo coste del nivel de CO2 en el aire

Author

Huarte Rubio, Jaime and Artigas Maestre, José Ignacio

Abstract

En el presente proyecto se desarrolla un dispositivo capaz de medir el nivel de dióxido de carbono en el aire. Su función principal es medir la concentración de este gas para indicar cuando es necesario ventilar un espacio cerrado, concretamente del entorno educativo, para así mejorar la calidad del aire y la salud de las personas encontradas en dicho espacio. Se estudian previamente las especificaciones que debe tener un medidor de estas características, obteniendo así unos objetivos a cumplir en el presente trabajo. Para conseguirlos, se ha llevado a cabo tanto el diseño del hardware como del software de un prototipo funcional, considerando las distintas posibilidades de elementos electrónicos a incorporar y de las herramientas de software a emplear, manteniendo la idea de un bajo coste. El prototipo es capaz de medir, a través de un sensor, la concentración de dióxido de carbono y de mostrar las mediciones por una pantalla integrada en el dispositivo. Además, se encarga de enviar los datos medidos a través de WiFi a una plataforma web, utilizando la tecnología del Internet de las Cosas, permitiendo así ver la evolución temporal de las mediciones, a través de una gráfica, y poder controlar de forma remota la calibración del dispositivo. También se incorporan medios de alerta para notificar de mediciones no deseadas para iniciar la correspondiente ventilación de la sala. El dispositivo también es dotado de autonomía propia, al incorporar un sistema de batería que alimenta al dispositivo, pudiendo recargar la batería, aportando así mayor usabilidad al medidor. Con el desarrollo de este trabajo se busca conseguir un medidor funcional, transportable y de bajo coste, capaz de ser empleado en el ambiente escolar y universitario de manera sencilla.

Published
2021

28. The Gods die in museums

Author

Delgado Rubio, Jaime and Delgado Rubio, Jaime

Abstract

Recently, Johannes Neurath’s book, titled Subdue the gods, doubt the images (2020) was published, which, among other things, warns that, in the archaeological museums of Mexico, including the National Institute of Anthropology and History of Mexico City, there has been an “ontological mistreatment” of the sacred images of the pre-Hispanic era through their removal from their original locations and indistinct placement in large and cold rooms packed with monoliths, without any consideration for the fact that some were – and continue to be – images bestowed with power and influence by many communities today.

Published
2021

32. When divulgation reaches us

Author

Delgado Rubio, Jaime and Delgado Rubio, Jaime

Abstract

In 2018, Mexico held its presidential election; its results soon clearly indicated that the left-wing candidate, with a degree in political science and a fierce critic of the ruling political system, Andrés Manuel López Obrador, would become President. Following his triumph, many cultural organizations, unions and employees of the field jubilantly celebrated what they thought would mean a strengthening of cultural policies and a kind of return to the years of President Lázaro Cárdenas del Río who put archeology, indigenism and culture at the heart of his government policies.

Published
2020

35. Maternidades políticas: ANÁLISIS DEL HALLAZGO DE UNA OFRENDA FEMENINA EN TEOTIHUACAN.

Author

Delgado Rubio, Jaime

Subjects
*ANCIENT figurines, *WOMEN in mythology, TEOTIHUACAN Site (San Juan Teotihuacan, Mexico)
Abstract

El articulo discute sobre la análisis del hallazgo de una ofrenda femenina en Teotihuacan con el enfoque de la importante ofrenda cerámica representan únicamente a mujeres y una ofrenda de figurillas femeninas localizada al oriente de la antigua ciudad de Teotihuacan

Published
2022

37. MicroRNA-199b Deregulation Shows a Strong SET-Independent Prognostic Value in Early-Stage Colorectal Cancer

Author

Cristóbal, Ion, primary, Rubio, Jaime, additional, Torrejón, Blanca, additional, Santos, Andrea, additional, Caramés, Cristina, additional, Luque, Melani, additional, Sanz-Álvarez, Marta, additional, Alonso, Ruth, additional, Zazo, Sandra, additional, Madoz-Gúrpide, Juan, additional, Rojo, Federico, additional, and García-Foncillas, Jesús, additional

Published
2020
Full Text
View/download PDF

39. MicroRNA-199b Downregulation Confers Resistance to 5-Fluorouracil Treatment and Predicts Poor Outcome and Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Patients

Author

Cristóbal, Ion, primary, Rubio, Jaime, additional, Santos, Andrea, additional, Torrejón, Blanca, additional, Caramés, Cristina, additional, Imedio, Laura, additional, Mariblanca, Sofía, additional, Luque, Melani, additional, Sanz-Alvarez, Marta, additional, Zazo, Sandra, additional, Madoz-Gúrpide, Juan, additional, Rojo, Federico, additional, and García-Foncillas, Jesús, additional

Published
2020
Full Text
View/download PDF

42. Clinical outcomes of abiraterone acetate + prednisone (AA) + bone resorption inhibitors (BRI) versus AA alone as first-line therapy for castration-resistant prostate cancer (CRPC) with bone metastases (BM) in an international multicenter database.

Author

Francini, Edoardo, primary, Montagnani, Francesco, additional, Nuzzo, Pier Vitale, additional, Gonzalez-Velez, Miguel, additional, Alimohamed, Nimira S., additional, Cigliola, Antonio, additional, Moreno, Irene, additional, Rubio, Jaime, additional, Crivelli, Francesca, additional, Shaw, Grace, additional, Petrioli, Roberto, additional, Bengala, Carmelo, additional, Francini, Guido, additional, Foncillas, Jesus Garcia, additional, Sweeney, Christopher, additional, Higano, Celestia S., additional, Bryce, Alan Haruo, additional, Harshman, Lauren Christine, additional, Lee-Ying, Richard, additional, and Heng, Daniel Yick Chin, additional

Published
2020
Full Text
View/download PDF

43. Fichas clínicas simuladas en kinesiología

Author

Contreras Briceño, Felipe Andrés, primary, Rojas Muñoz, Cynthia Teresa, additional, Passalacqua Rubio, Jaime, additional, García Valdés, Patricio, additional, Espinosa Ramírez, Maximiliano, additional, López Fuenzalida, Antonio, additional, Fuentes Cimma, Javiera, additional, and Gabrielli Nervi, Luigi Arnaldo, additional

Published
2019
Full Text
View/download PDF

44. Educación Mutua: Un noticiero arqueológico hecho por niños y para niños

Author

Delgado Rubio, Jaime and Guerrero García, Juan José

Subjects
Defensa, Universidad de Los Andes, Educación, Teotihuacan, Cocreation, Conservación, Defence, Young people, Artículos, Artículos [Boletín Antropológico No.97], Cocreación, Preservation
Abstract

Hoy en día, la periferia de la ciudad arqueológica de Teotihuacan sufre un proceso gradual de destrucción debido al crecimiento urbano de las localidades contiguas y al impacto demográfico que implicó su conurbación con la Ciudad de México; asimismo, enfrenta una problemática entre la población y el Instituto Nacional de Antorpología e Historia. En este artículo abordamos esta problemática desde una perspectiva generacional; hemos diseñado una estrategia de divulgación arqueológica denominada ‘Arqueólogos en Apuros’, que reproduce un noticiero infantil multimedia conducido por títeres reporteros, con el objetivo de revelar la forma en la cual los escolares se relacionan con su patrimonio y toman posición frente a éste desde su perspectiva local o regional. Today, the periphery of the archaeological city of Teotihuacan undergoes a gradual process of destruction due to the urban growth of the contiguous localities and the demographic impact that its conurbation implied with Mexico City; also, it faces a problem between the population and the National Institute of Antorpology and History. In this article we approach this problem from a generational perspective; we have designed an archaeological outreach strategy called ‘Archaeologists in Trouble’, which reproduces a multimedia children’s newscast led by reporter puppets, with the aim of revealing the way in which schoolchildren relate to their heritage and take a stand against it from their perspective. local or regional perspective. 133-167 jaimedelrub8@gmail.com ometusco62@yahoo.com.mx Semestral http://www.saber.ula.ve/boletin_antropologico/

Published
2019

46. Origin of the large N 1s binding energy in x-ray photoelectron spectra of calcined carbonaceous materials

Author

Casanovas, Jordi, Ricart, Josep Manel, Rubio, Jaime, Illas, Francesc, and Jimenez-Mateos, Juan Miguel

Subjects
Petroleum coke -- Research, Binding energy -- Research, Photoelectron spectroscopy -- Research, Chemistry
Abstract

The N 1s spectrum of nitrogen-containing calcined carbonaceous materials were investigated via experiments and ab initio Hartree-Fock wave function computations. The results, which showed that the N 1s core level shifts between two compounds are caused by initial state effects, indicated the presence of pyridinic, pyrrolic and graphitic nitrogen atoms with binding energies of around 399.0, 400.3 and 4010-403.0 eV.

Published
1996

47. À la découverte de patrimoines inattendus avec les enfants

Author

Edouard, Jean Charles, Delgado Rubio, Jaime, Edouard, Jean Charles, and Delgado Rubio, Jaime

Abstract

Afin de découvrir les patrimoines des enfants, de repenser le patrimoine et sa transmission, et aussi afin de fomenter l’ethnographie collaborative avec les enfants, cette recherche propose une perspective interdisciplinaire avec une approche archéologique et anthropologique. Pour ce faire, une distinction est établie entre le patrimoine « vivant » et le patrimoine « mort », entre l’imagination et la recréation du patrimoine chez les enfants, et est abordée la capacité d’agir de l’enfant, tout comme la vision que celui-ci a du patrimoine. A partir d’une perspective horizontale et d’une perspective ascendante, cet article aborde le travail collaboratif inter- et intra-générationnel par le biais de l’inversion du paradigme centrée sur l’adulte, grâce à quoi les enfants sont perçus comme des agents et non plus comme des récepteurs passifs du patrimoine., Con el objetivo de descubrir los patrimonios de los niños, repensar el patrimonio y su trans-misión, así como fomentar la etnografía colaborativa con los niños, esta investigación plantea una perspectiva interdisciplinaria con un enfoque arqueológico y antropológico. Para ello, se establece la distinción entre el patrimonio “vivo” y “muerto”, entre imaginación y recreación patrimonial por parte de los niños, y se dilucida la agencia del niño y la visión infantil que tiene sobre él [sobre el patrominio]. Desde una perspectiva horizontal y una perspectiva as-cendente, este artículo aborda el trabajo colaborativo inter e intrageneracional, mediante la inversión del paradigma centrado en el adulto, con lo cual los niños son vistos como agentes, y no como receptores pasivos del patrimonio

Published
2019

48. Isaac Costero Tudanca. Vida y obra en su etapa vallisoletana

Author

Bernárdez Rubio, Jaime, Fernández Ares, Mario, Río Hortega Bereciartu, Juan del, and Universidad de Valladolid. Facultad de Medicina

Subjects
Isaac Costero, Anatomía Patológica española, Microglía, Microfotografía
Abstract

D. Isaac Costero Tudanca (1903-1979) está considerado como uno de los anatomopatólogos más importantes a nivel mundial del s. XX. Su trayectoria científica se inicia junto a su maestro Pío del Río-Hortega en Madrid, tanto en el laboratorio de Histología Normal y Patológica de la JAE, en la Residencia de Estudiantes, como posteriormente en el Instituto Nacional del Cáncer a partir de 1930. Su formación se completa en sus estancias en Alemania y Francia siendo pensionado precisamente por la JAE. En 1931, logra la cátedra de Histología y AP de la Facultad de Medicina de Valladolid, cargo que ocupara hasta el comienzo de la Guerra Civil. Exiliado en México, crea una importante escuela de anatomopatólogos en tierras sudamericanas donde se le reconoce su enorme labor como investigador y docente., Grado en Medicina

Published
2018

50. Efficacy of bone resorption inhibitors (BRI) + abiraterone acetate + prednisone (AA) vs. AA alone as first-line therapy for men with castration-resistant prostate cancer (CRPC) and bone metastases (BM) in an international multicenter hospital-based registry.

Author

Francini, Edoardo, primary, Montagnani, Francesco, additional, Pier Vitale, Nuzzo, additional, Alimohamed, Nimira S., additional, Moreno Candilejo, Irene, additional, Rosellini, Pietro, additional, Gonzalez-Velez, Miguel, additional, Rubio, Jaime, additional, Zhang, Li, additional, Shaw, Grace, additional, Crivelli, Francesca, additional, Petrioli, Roberto, additional, Bengala, Carmelo, additional, Francini, Guido, additional, Foncillas, Jesus Garcia, additional, Bryce, Alan Haruo, additional, Sweeney, Christopher, additional, Harshman, Lauren Christine, additional, Lee-Ying, Richard, additional, and Heng, Daniel Yick Chin, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results