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762 results on '"Rubini, C."'

19. Positive neck margin at frozen section analysis is a significant preditor of tumour recurrence and poor survival after pancreatoduodenectomy for pancreatic cancer

Author

Guarneri, G., primary, Crippa, S., additional, Belfiori, G., additional, Partelli, S., additional, Pagnanelli, M., additional, Gasparini, G., additional, Balzano, G., additional, Schiavo Lena, M., additional, Rubini, C., additional, Doglioni, C., additional, Zamboni, G., additional, and Falconi, M., additional

Published
2020
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20. Site and size of MPD dilation in determining malignant degeneration of IPMNs.

Author

Aleotti, F., primary, Crippa, S., additional, Longo, E., additional, Belfiori, G., additional, Partelli, S., additional, Di Salvo, F., additional, Balzano, G., additional, De Cobelli, F., additional, Arcidiacono, P., additional, Petrone, M., additional, Rubini, C., additional, Zamboni, G., additional, Schiavo Lena, M., additional, Doglioni, C., additional, and Falconi, M., additional

Published
2020
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21. Low grade IPMNs: A test of conscience

Author

Aleotti, F., primary, Crippa, S., additional, Longo, E., additional, Belfiori, G., additional, Partelli, S., additional, Tamburrino, D., additional, D'andria Ursoleo, J., additional, Rubini, C., additional, Zamboni, G., additional, and Falconi, M., additional

Published
2020
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23. OC.09.5 SIZE AND SITE OF MAIN PANCREATIC DUCT DILATION CORRELATES WITH DISTINCT RISK OF MALIGNANCY IN MAIN-DUCT/ MIXED INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS OF THE PANCREAS

Author

Crippa, S., primary, Aleotti, F., additional, Belfiori, G., additional, Longo, E., additional, Di Salvo, F., additional, Partelli, S., additional, Balzano, G., additional, De Cobelli, F., additional, Arcidiacono, P.G., additional, Rubini, C., additional, Zamboni, G., additional, Schiavo Lena, M., additional, Doglioni, C., additional, and Falconi, M., additional

Published
2020
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25. 1905P BAP1 and miR-31 combination predicts outcome in epithelioid malignant pleural mesothelioma

Author

Pecci, F., primary, Cantini, L., additional, Cognigni, V., additional, Murrone, A., additional, Monaco, F., additional, Rubini, C., additional, Barbisan, F., additional, Copparoni, C., additional, Rinaldi, S., additional, Fiordoliva, I., additional, Di Pietro Paolo, M., additional, Scarpelli, M., additional, Tomasetti, M., additional, Santarelli, L., additional, and Berardi, R., additional

Published
2020
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36. The immune phenotype of tongue squamous cell carcinoma predicts early relapse and poor prognosis

Author

Troiano, G, Rubini, C, Togni, L, Caponio, VCA, Zhurakivska, K, Santarelli, A, Cirillo, N, Lo Muzio, L, Mascitti, M, Troiano, G, Rubini, C, Togni, L, Caponio, VCA, Zhurakivska, K, Santarelli, A, Cirillo, N, Lo Muzio, L, and Mascitti, M

Abstract

BACKGROUND: In patients with squamous cell carcinoma of the oral tongue (OTSCC), current tumor node metastasis staging system fails to identify at-risk patients associated with early relapse and poor prognosis despite complete surgical resection. Given the importance of tumor-infiltrating lymphocytes (TILs) in the development of cancers, here we investigated the prognostic significance of the immune phenotype in OTSCC. METHODS: Hematoxylin-eosin stained sections of OTSCCs from 211 patients were evaluated. Cancers were classified as (a) immune-inflamed when TILs were found next to tumor cell nests; (b) immune-excluded when TILs were found in the stroma, outside the tumor; and (c) immune-desert for tumors lacking lymphocyte infiltrate. The prognostic significance of these immune phenotypes classes was investigated. Data were further validated on an independent cohort from The Cancer Genome Atlas database. RESULTS: Immune-desert phenotype was the least represented group of OTSCCs in our cohort (11.8%) and served as an independent prognostic factor. Patients with immune-desert tumors exhibited worse disease-specific survival (HR = 2.673; [CI: 95% 1.497-4.773]; P = .001), overall survival (HR = 2.591; [CI: 95% 1.468-4.572]; P = .001), and disease-free survival (HR = 2.313; [CI: 95% 1.118-4.786]; P = .024) at multivariate analysis. CONCLUSIONS: We identified a specific subgroup of OTSCCs with poor prognosis. Tumor-infiltrating lymphocytes density and localization could serve as an integrative parameter to the current staging system and inform the selection of most appropriate treatments. In particular, the tumor immune phenotype could improve the stratification of patients with more aggressive disease.

Published
2020

46. Oral tuberculosis: a tongue case report

Author

Battista, G., primary, Lo Russo, L., additional, Padovano Di Leva, A., additional, Rubini, C., additional, Sberna, M. T., additional, Bollero, R., additional, De Santis, D., additional, D'''''Agostino, A., additional, Bertossi, D., additional, and Lo Muzio, L., additional

Published
2018
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48. Vascular endothelial growth factor and microvessel density around healthy and failing dental implants.

Author

Cornelini R, Artese L, Rubini C, Fioroni M, Ferrero G, Santinelli A, and Piattelli A

Abstract

Inflammatory infiltrate may be important in the evolution of inflammatory processes involving peri-implant tissues. Angiogenesis is an important feature of inflammation and healing, but its role in the development and progression or in the healing of periodontal lesions has not been elucidated. Vascular endothelial growth factor (VEGF) is a potent inducer of endothelial cell proliferation. The aim of the present study was to conduct a comparative immunohistochemical evaluation of VEGF and microvessel density (MVD) in normal keratinized gingiva and in peri-implant soft tissues surrounding failing implants. Fifteen patients participated in this study. Ten biopsies were taken from healthy keratinized gingiva, and 10 were taken from peri-implant soft tissues surrounding failing non-submerged implants. In healthy sites, the endothelial lining cells of the vessels always tested positive for VEGF; also, VEGF intensity was high in most cases. Stromal cells were positive for VEGF in 70% to 90% of samples. The MVD was 60.250 +/- 5.123. In peri-implantitis samples, the cells of the inflammatory infiltrate were positive for VEGF in 80% to 100% of cases, and the VEGF intensity was low in all cases. The stromal cells were positive for VEGF in 90% to 100% of cases, and in most cases the intensity was low. The MVD was 101.800 +/- 11.256. The difference in MVD between healthy sites and peri-implantitis was statistically significant (P = .0158). Expression of VEGF was lower in peri-implantitis samples, and this difference was statistically significant (P = .0373). Because of its extensive presence, VEGF is probably a factor in both the maintenance of periodontal physiology and in the progression of peri-implant inflammatory disease. [ABSTRACT FROM AUTHOR]

Published
2001

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