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Context.-Controversies and uncertainty persist in prostate cancer grading. prostate cancer grading. Objective.-To update grading recommendations Data Sources.-Critical review of the literature along with pathology and clinician surveys. Conclusions.-Percent Gleason pattern 4 (%GP4) is as follows: (1) report %GP4 in needle biopsy with Grade Groups (GrGp) 2 and 3, and in needle biopsy on other parts (jars) of lower grade in cases with at least 1 part showing Gleason score (GS) 4 + 4 = 8; and (2) report %GP4: less than 5% or less than 10% and 10% increments thereafter. Tertiary grade patterns are as follows: (1) replace "tertiary grade pattern'' in radical prostatectomy (RP) with "minor tertiary pattern 5 (TP5),'' and only use in RP with GrGp 2 or 3 with less than 5% Gleason pattern 5; and (2) minor TP5 is noted along with the GS, with the GrGp based on the GS. Global score and magnetic resonance imaging (MRI)targeted biopsies are as follows: (1) when multiple undesignated cores are taken from a single MRI-targeted lesion, an overall grade for that lesion is given as if all the involved cores were one long core; and (2) if providing a global score, when different scores are found in the standard and the MRI-targeted biopsy, give a single global score (factoring both the systematic standard and the MRI-targeted positive cores). Grade Groups are as follows: (1) Grade Groups (GrGp) is the terminology adopted by major world organizations; and (2) retain GS 3 + 5 = 8 in GrGp 4. Cribriform carcinoma is as follows: (1) report the presence or absence of cribriform glands in biopsy and RP with Gleason pattern 4 carcinoma. Intraductal carcinoma (IDCP) is as follows: (1) report IDC-P in biopsy and RP; (2) use criteria based on dense cribriform glands (>50% of the gland is composed of epithelium relative to luminal spaces) and/or solid nests and/or marked pleomorphism/necrosis; (3) it is not necessary to perform basal cell immunostains on biopsy and RP to identify IDC-P if the results would not change the overall (highest) GS/GrGp part per case; (4) do not include IDC-P in determining the final GS/GrGp on biopsy and/or RP; and (5) "atypical intraductal proliferation (AIP)'' is preferred for an intraductal proliferation of prostatic secretory cells which shows a greater degree of architectural complexity and/or cytological atypia than typical high-grade prostatic intraepithelial neoplasia, yet falling short of the strict diagnostic threshold for IDC-P. Molecular testing is as follows: (1) Ki67 is not ready for routine clinical use; (2) additional studies of active surveillance cohorts are needed to establish the utility of PTEN in this setting; and (3) dedicated studies of RNA-based assays in active surveillance populations are needed to substantiate the utility of these expensive tests in this setting. Artificial intelligence and novel grading schema are as follows: (1) incorporating reactive stromal grade, percent GP4, minor tertiary GP5, and cribriform/intraductal carcinoma are not ready for adoption in current practice.

Exoplanetary biosignatures, molecular compounds which indicate a likelihood of extraterrestrial life, can be detected by highly sensitive spectroscopy of starlight which passes through the atmospheres of exoplanets towards the Earth. Such sensitive measurements can only be accomplished with the next generation of telescopes, leading to a corresponding increase in cost and complexity spectrometers. Integrated astrophotonic instruments are well-suited to address these challenges through their low-cost fabrication and compact geometries. We propose and characterize an integrated photonic gas sensor which detects the correlation between the near-infrared quasi-periodic vibronic absorption line spectrum of a gas and a silicon waveguide ring resonator transmittance comb. This technique enables lock-in amplification detection for real-time detection of faint biosignatures for reduced observation timescales and rapid exoplanetary atmosphere surveys using highly compact instrumentation.

Absorption spectroscopy is widely used in sensing and astronomy to understand molecular compositions on microscopic to cosmological scales. However, typical dispersive spectroscopic techniques require multichannel detection, fundamentally limiting the ability to detect extremely weak signals when compared to direct photometric methods. We report the realization of direct spectral molecular detection using a silicon nanophotonic waveguide resonator, obviating dispersive spectral acquisition. We use a thermally tunable silicon ring resonator with a transmission spectrum matched and cross-correlated to the quasi-periodic vibronic absorption lines of hydrogen cyanide. We show that the correlation peak amplitude is proportional to the number of overlapping ring resonances and gas lines, and that molecular specificity is obtained from the phase of the correlation signal in a single detection channel. Our results demonstrate on-chip correlation spectroscopy that is less restricted by the signal-to-noise penalty of other spectroscopic approaches, enabling the detection of faint spectral signatures.

We present the design of integrated astrophotonic instruments for high background atmospheric gas detection. Such instruments can be fibre-coupled to long focal length space telescopes as compact, flexure-free, instruments., Conference on Lasers and Electro-Optics/Pacific Rim 2020, August 3-5, 2020, Sydney Australia

Absorption spectroscopy is a powerful technique for characterizing remote gas composition where direct interaction with a target it not possible. While dispersive spectroscopy is typically used to acquire a spectrum with which the gas presence is determined, correlation spectroscopy can directly detect such spectral features in a single detection channel. Here we present a novel integrated photonics correlation technique on an integrated photonic platform which uses real-time spectral processing to generate a multiline gas specific detection signal., 2020 Photonics North (PN), May 26-28, 2020, Niagara Falls, ON, Canada

In this work, the authors evaluated the access resistance of InP high electron mobility transistors (HEMTs) and their degradation during wafer processing. The transfer resistance, which was rarely separated from other components of the total access resistance of InP HEMTs in the literature, was found to be the dominant component of the access resistance. It was also found that the transfer resistance degraded during wafer processing. The selection of the ohmic metal stack and its impact on both the metal-cap contact resistance and the transfer resistance was also investigated. The observations in their experiments and relevant discussions in the report are expected to be useful in the identification of improvement opportunities in both material growth and wafer fabrication of InP HEMTs.

© 2017 European Association of Urology Background In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular characterisation have resulted in multiple areas where there is lack of evidence or low level of evidence. The Advanced Prostate Cancer Consensus Conference (APCCC) 2017 addressed some of these topics. Objective To present the report of APCCC 2017. Design, setting, and participants Ten important areas of controversy in APC management were identified: high-risk localised and locally advanced prostate cancer; “oligometastatic” prostate cancer; castration-naïve and castration-resistant prostate cancer; the role of imaging in APC; osteoclast-targeted therapy; molecular characterisation of blood and tissue; genetic counselling/testing; side effects of systemic treatment(s); global access to prostate cancer drugs. A panel of 60 international prostate cancer experts developed the program and the consensus questions. Outcome measurements and statistical analysis The panel voted publicly but anonymously on 150 predefined questions, which have been developed following a modified Delphi process. Results and limitations Voting is based on panellist opinion, and thus is not based on a standard literature review or meta-analysis. The outcomes of the voting had varying degrees of support, as reflected in the wording of this article, as well as in the detailed voting results recorded in Supplementary data. Conclusions The presented expert voting results can be used for support in areas of management of men with APC where there is no high-level evidence, but individualised treatment decisions should as always be based on all of the data available, including disease extent and location, prior therapies regardless of type, host factors including comorbidities, as well as patient preferences, current and emerging evidence, and logistical and economic constraints. Inclusion of men with APC in clinical trials should be strongly encouraged. Importantly, APCCC 2017 again identified important areas in need of trials specifically designed to address them. Patient summary The second Advanced Prostate Cancer Consensus Conference APCCC 2017 did provide a forum for discussion and debates on current treatment options for men with advanced prostate cancer. The aim of the conference is to bring the expertise of world experts to care givers around the world who see less patients with prostate cancer. The conference concluded with a discussion and voting of the expert panel on predefined consensus questions, targeting areas of primary clinical relevance. The results of these expert opinion votes are embedded in the clinical context of current treatment of men with advanced prostate cancer and provide a practical guide to clinicians to assist in the discussions with men with prostate cancer as part of a shared and multidisciplinary decision-making process. At the Advanced Prostate Cancer Consensus Conference, 10 important areas of controversy in advanced prostate cancer management were identified, discussed, and the experts voted on 150 predefined consensus questions. The full report of the results is summarised here.

In this review, we summarize and discuss our recent studies of subwavelength grating (SWG) structures for engineering the refractive index of silicon microphotonic waveguides. The SWG effect allows control of the effective refractive index of a waveguide core over a range spanning the values of the cladding material and silicon by lithographic patterning. We demonstrate this effect with the example of segmented photonic wire waveguides, which are shown to exhibit low propagation loss, and can be used to make highly efficient waveguide crossings and in-plane fiber-chip coupling structures. Other applications of SWG structures in silicon photonic waveguide devices include surface grating couplers with enhanced performance and simplified fabrication requirements, as well as a novel curved waveguide sidewall grating micro-spectrometer, in which an SWG structure fulfills a dual purpose by acting as an effective slab waveguide for diffracted light and as a lateral cladding for a channel waveguide.

Objectives: To assess rates of starting or stopping antibiotics across different hospitals. Methods: We used barcode medication administration data to measure antibiotic use on acute-care wards in 128 Veterans Affairs medical centres (VAMCs) in 2010. A treatment day (TD) was defined as the administration of any antibiotic on a given day. A treatment period (TP) was defined as an interval of inpatient antimicrobial therapy with gaps of ≤1 day in TDs. The rate of starting antibiotics was calculated for inpatients who had not yet started antibiotics, as the number of start events divided by the 'person-time at risk'. The rate of stopping antibiotics was calculated analogously for inpatients that were on antibiotics. Once individuals had stopped antibiotics they were removed from further analysis. Per-day start and stop rates were also calculated for each day of hospitalization. Results: The hospital mean rate of starting the first TP was 18.1 start events/100 days at risk (range 8.4-25.6/100 days at risk). The mean hospital stopping rate was 21.1 stop events/100 days at risk (range 13.3-29.5/100 days at risk). The ratio of a facility's starting and stopping rates was highly correlated with overall antibiotic use in TDs/1000 patient-days (rs=0.92, P

Subwavelenth structures offer exciting new opportunities for integrated optics. Effective refractive index can be chosen from a broad range by lithographic patterning using just two materials. Many practical subwavelength engineered devices already demonstrated, with superior performance compared to their conventional counterparts and likely many more to come.

Interpreting variants, especially noncoding ones, in the increasing number of personal genomes is challenging. We used patterns of polymorphisms in functionally annotated regions in 1092 humans to identify deleterious variants; then we experimentally validated candidates. We analyzed both coding and noncoding regions, with the former corroborating the latter. We found regions particularly sensitive to mutations ("ultrasensitive") and variants that are disruptive because of mechanistic effects on transcription-factor binding (that is, "motif-breakers"). We also found variants in regions with higher network centrality tend to be deleterious. Insertions and deletions followed a similar pattern to single-nucleotide variants, with some notable exceptions (e.g., certain deletions and enhancers). On the basis of these patterns, we developed a computational tool (FunSeq), whose application to ~90 cancer genomes reveals nearly a hundred candidate noncoding drivers.

Athermal operation of silicon waveguides for the TM and TE mode is achieved using the bridged subwavelength grating (BSWG) waveguide geometry. For the TM mode the experimental results show that the temperature-induced wavelength shift (dλ/dT) is an order of magnitude smaller for the BSWG waveguides with grating duty cycle, waveguide and bridge widths of 42%, 490 nm and 220 nm, respectively, as compared to standard photonics wires (PW). For the TE mode similar results are achieved by using the bridge width of 200 nm and similar duty cycle and waveguide width. A temperature-induced shift of only -2.5 pm/°C is reported for the TM polarized light. Propagation losses of BSWG waveguides for both polarizations were measured to be about 8 dB/cm, comparable to that of PWs. © 2012 SPIE., Photonics North 2012, June 6-8, 2012, Montreal, QC, Canada, Series: Proceedings of SPIE; no. 8412

We report a silicon-on-insulator ring resonator biosensor array with one output port, using wavelength division multiplexing as the addressing scheme. With the use of on-chip referencing for environmental drift cancellation, simultaneous monitoring of multiplexed molecular bindings is demonstrated, with a resolution of 0.3 pg/mm(2) (40 ag of total mass) for protein concentrations over 4 orders of magnitude down to 20 pM. Reactions are measured over time periods as long as 3 h with high stability.

Surface grating couplers enable efficient coupling of light between optical fibers and planar waveguide circuits. While traditional grating designs require two etch steps for efficient coupling to silicon-on-insulator waveguides, recently proposed subwavelength structured gratings can achieve the same coupling efficiencies with a single etch step, thereby significantly reducing fabrication complexity. Here we demonstrate that such couplers can be fabricated on a large scale with ultra-violet lithography, achieving a 5 dB coupling efficiency at 1,550 nm. Through both simulations and experiments we give physical insight on how pattern fidelity impacts the performance of these couplers, and propose strategies to deal with inevitable process variations.

We review our advances in diffractive and subwavelength grating coupler structures for microphotonic waveguides. We present a subwavelength grating fiber-chip edge coupler with a loss as low as 0.9 dB and with minimal wavelength dependence over a broad wavelength range exceeding 200 nm. We also present fiber-to-chip surface grating couplers based on subwavelength effective medium. The effective medium refractive index is engineered to control the strength of the grating and thereby maximize coupling efficiency, while mitigating back reflections at the same time. We analyze the fabrication tolerances of the coupler, which are of particular relevance for large scale photonic fabrication. Furthermore, we present the first grating coupler for micrometric silicon rib waveguides, which is particularly challenging since the coupler waveguide region is multimode. We experimentally demonstrate grating couplers in 1.5 μm thick silicon ridge waveguides with a coupling efficiency of 2.2 dB and a 3 dB bandwidth of 40 nm. An inverse taper is used to match the fundamental mode of the interconnection waveguide with the optimum grating coupler excitation field, with negligible higher order mode excitation. The coupler was fabricated using i-line stepper lithography and single etch step. © 2012 IEEE., 14th International Conference on Transparent Optical Networks, ICTON 2012, 2 July 2012 through 5 July 2012, Coventry

Silicon photonic wire waveguides are usually highly birefringent, so they are generally designed to operate for one particular polarization. For commonly used waveguides with a silicon thickness of 220 nm, TE polarization is preferred since TM is only weakly guided. For waveguides with a silicon thickness larger than 250 nm, both TE and TM polarizations have been employed. Overall, the choice of polarization has largely appeared arbitrary. In this presentation we review the pertinent polarization-dependent waveguide properties, including losses, back-reflection, polarization conversion and fabrication tolerances, with the intent to suggest guidelines for choosing the proper polarization. Through experimental evidence, we show that TM polarization has several important advantages and can support high performance resonators with a radius down to 2 μm. © 2012 SPIE., Silicon Photonics VII, January 22-25, 2012, San Francisco, CA, USA, Series: Proceedings of SPIE; no. 8266

We demonstrate all-optical XOR logic function for 40Gb/s DPSK signals in the C-band, based on four-wave mixing (FWM) in a silicon nanowire. Error-free operation with a system penalty of ∼ 4.3dB at 10−9 BER has been achieved.

We demonstrate all-optical wavelength conversion at 10 Gb/s for differential phase-shift keyed (DPSK) data in the C-band, based on four-wave mixing (FWM) in a silicon ring resonator. Error-free operation with a system penalty of ∼ 4.1 dB at 10−9 BER is achieved.

Three examples of cavity-enhanced measurements of refractive index and optical absorption are discussed. Using microphotonic silicon-on-insulator ring-resonators we determine the concentration of cyclohexane and m-xylene at detection levels of 300-3000 ppm. The gases are first absorbed into a siloxane polymer and its refractive index change is detected by a characteristic wavelength shift of the cavity resonance. In a second device phase-shift cavity ring-down spectroscopy is applied to simultaneously measure the optical absorption at two wavelengths of either a dye, nucleic acids or a pharmaceutical component. Multiplexing the ring-down measurement permits dual wavelength absorption spectroscopy without the use of a dispersion element. Finally, a combination of resonance wavelength measurements and cavity ring-down spectroscopy is used to simultaneously determine the change in refractive index and the absorption induced by adsorption of ethylene diamine on a 300 μm silica sphere. A whispering gallery mode of the microsphere resonator is excited with intensity modulated light and the intensity and AM modulation phase of the Rayleigh backscattered light is measured. © 2012 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE)., Photonics and Optoelectronics Meetings (POEM) 2011: Optoelectronic Sensing and Imaging, November 2-5, 2011, Wuhan, Series: Proceedings of SPIE; no. 8332

We present a method of engineering the waveguide core refractive index locally on a silicon photonic chip using subwavelength gratings. Applications such as efficient waveguide crossings, fiber-chip couplers and multiplexer circuits are discussed., The 2011 Photonics Society Winter Topicals, Keystone, Colorado, January 10-12, 2011

Our progress in subwavelength structures in silicon waveguides is reviewed. Several practical implementations of subwavelength grating waveguides are discussed, including fibre-chip couplers, waveguide crossings and athermal waveguides. © 2011 IEEE., 8th IEEE International Conference on Group IV Photonics, GFP 2011, 14 September 2011 through 16 September 2011, London

In this paper, athermal subwavelength grating (SWG) waveguides are investigated. Both numerical simulations and experimental results show that a temperature independent behaviour can be achieved by combining two materials with opposite thermo-optic coefficients within the waveguide. SU-8 polymer with a negative thermo-optic coefficient (dn/dT = -1.1×10-4 K -1) is used in our silicon SWG waveguides to compensate for silicon's positive thermo-optic coefficient of 1.9×10-4 K-1. The grating duty ratio required to achieve an athermal behavior is reported to vary as a function of the operating wavelength and the waveguide dimensions. For example, for athermal waveguides of 260 nm in height, duty ratios of 61.3% and 83.3% were calculated for TE and TM polarized light respectively for a 450 nm wide waveguide, compared to ratios of 79% and 90% for a 350 nm wide waveguide. It is also reported that with increasing width, and increasing height, a smaller grating duty ratio is necessary to achieve an athermal behaviour. A smaller fraction of silicon would hence be needed to compensate for the polymer's negative thermo-optic effect in the waveguide core. Subwavelength sidewall grating (SWSG) waveguides are also proposed here as alternatives to high duty ratio SWG waveguides that are required for guiding TM polarized light. Assuming a duty ratio of 50%, the width of the narrow segments for temperature- independent behavior is found by numerical simulations to be 125 nm and 143 nm for TE and TM polarized light, respectively. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE)., Photonics North 2011, May 16-18, 2011, Ottawa, Ontario, Canada, Series: Proceedings of SPIE; no. 8007

A complete instrumentation system for interrogating silicon photonic wire waveguide sensor array chips has been built and demonstrated. The system is designed to read 16 or more photonic wire sensors on a single silicon chip simultaneously and in real time, while delivering sample fluid to the sensors through microfluidic channels fabricated monolithically on the chip. The chip can be inserted into the instrument, automatically aligned with input optics and fluid connection, and be ready for measurement in a few minutes. © 2011 IEEE., 8th IEEE International Conference on Group IV Photonics, GFP 2011, 14 September 2011 through 16 September 2011, London

We demonstrate silicon-chip-based instantaneous chromatic dispersion monitoring (GVD) for an ultrahigh bandwidth 640 Gbit/s differential phase-shift keying (DPSK) signal. This monitoring scheme is based on cross-phase modulation in a highly nonlinear silicon nanowire. We show that two-photon absorption and free-carrier-related effects do not compromise the GVD monitoring performance, making our scheme a reliable on-chip CMOS-compatible, all-optical, and real-time impairment monitoring approach for up to Terabit/s DPSK signals.

Photonic wire evanescent field (PWEF) sensor chips have been developed for multiplexed label free molecular detection. The sensors are made using 260 nm ×450 nm cross-section silicon waveguides folded into spirals less than 200 μm in diameter, but with an overall sensor length of more than a millimeter. The long propagation length gives a response to molecular binding much better than currently available tools for label-free molecular sensing. These sensors can be arrayed at densities up to ten or more per square millimeter. This talk reviews our ongoing work on the photonic wire sensor chip design and layout, on-chip integrated fluidics, optical coupling, and chip interrogation using arrays of grating couplers formed using sub-wavelength patterned structures. The goal is to develop a commercially viable sensor platform by addressing cost-of-instrumentation, cost per measurement, ease-of-use, and by increasing the number of sensors that can be simultaneously monitored. © 2011 IEEE., 2011 ICO International Conference on Information Photonics, IP 2011, 18 May 2011 through 20 May 2011, Ottawa, ON

We review recent advances in subwavelength and diffractive structures in planar waveguides. First, we present a new type of microphotonic waveguide, exploiting the subwavelength grating (SWG) effect. We demonstrate several examples of subwavelength grating waveguides and components made of silicon, operating at telecom wavelengths. The SWG technique allows for engineering of the refractive index of a waveguide core over a range as broad as 1.5-3.5 simply by lithographic patterning using only two materials, for example Si and SiO2. This circumvents an important limitation in integrated optics, which is the fixed value of the refractive indices of the constituent materials in the absence of an active tuning mechanism. A subwavelength grating fibre-chip microphotonic coupler is presented with a loss as low as 0.9 dB and with minimal wavelength dependence over a broad wavelength range exceeding 200 nm. It is shown that the SWG waveguides can be used to make efficient waveguide crossings with minimal loss and negligible crosstalk. We also present a diffractive surface grating coupler with subwavelength nanostructure, that has been implemented in a Si-wire evanescent field biological sensor. Furthermore, we discuss a new type of planar waveguide multiplexer with a SWG engineered nanostructure, yielding an operation bandwidth exceeding 170 nm for a device size of only 160 μm × 100 μm., Integrated Optics: Devices, Materials, and Technologies XV, January 24-26, 2011, San Francisco, CA, USA, Series: Proceedings of SPIE; no. 7941

We are developing a photonic wire evanescent field (PWEF) sensor chip using 260 nm x 450 nm cross-section silicon photonic wire waveguides. The waveguide mode is strongly localized near the silicon surface, so that light interacts strongly with molecules bound to the waveguide surface. The millimeter long sensor waveguides can be folded into tight spiral structures less than 200 micrometers in diameter, which can be arrayed at densities up to ten or more independent sensors per square millimeter. The long propagation length in each sensor element gives a response to molecular binding much better than currently available tools for label-free molecular sensing. Cost of instrumentation, cost per measurement, ease-of-use, and the number of sensors that can be simultaneously monitored on a sensor array chip are equally important in determining whether an instrument is practical for the end user and hence commercially viable. The objective of our recent work on PWEF sensor array chips and the associated instrumentation is to address all of these issues. This conference paper reviews our ongoing work on the photonic wire sensor chip design and layout, on-chip integrated fluidics, optical coupling, and chip interrogation using arrays of grating couplers formed using sub-wavelength patterned structures. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE)., SPIE BiOS, January 22-23, 2011, San Francisco, CA, USA, Series: Proceedings of SPIE; no. 7888

We present a method for designing temperature independent silicon waveguide devices using the subwavelength grating effect. Photonic wire waveguides are patterned with periodic gaps and filled with SU-8 polymer to cancel the silicon thermo-optic effect., Integrated Photonics Research, Silicon and Nanophotonics, 12–15 June 2011, Toronto, ON, Canada

Fibre-to-chip grating couplers are an efficient means for injecting and extracting light from silicon-wire waveguides. Here we present the design of single-etch couplers, based on effective media implemented with sub-wavelength gratings. We show that the pitch of these sub-wavelength structures can be increased to make their fabrication compatible with deep-ultraviolet lithography, without compromising their effective medium behavior. We experimentally demonstrate fully-etched grating couplers fabricated with DUV lithography. © 2011 IEEE., 2011 ICO International Conference on Information Photonics, IP 2011, 18 May 2011 through 20 May 2011, Ottawa, ON

As a result of the evolution semiconductor fabrication tools and methods over several decades, it now possible to routinely design and make optical devices with features comparable to or smaller than the wavelength of the light that propagates through these structures. This paper will review some silicon optical structures with critical features at these extremely short length scales. For example it becomes possible to create segmented waveguide structures with optical properties that can be tuned continuously between those of the cladding and waveguide core, using lithographic patterning rather than varying etch depth. Using thin high index contrast waveguides and the correct polarization, the optical electric field profiles can be shaped to maximize the coupling to molecular monolayers or cladding layers with specific functionality. Examples are given from our recent work on optical biosensors chips which employ grating couplers made by sub-wavelength digital patterning, and use waveguides optimized for coupling to molecular monolayers., Silicon Photonics VI, January 23-26, 2011, San Francisco, CA, USA, Series: Proceedings of SPIE; no. 7943

We review our work on silicon wire devices designed for evanescent field sensor arrays and ultra-compact dense optical comb filters, both taking advantage of a spiral cavity resonator design. Two sensor array configurations are described, and monitoring of biomolecular binding is demonstrated with a detection limit of 0.3 pg/mm2. On-chip temperature drift compensation is achieved by using a reference resonator. A novel grating coupler using subwavelength structures facilitates the coupling of light between the optical fiber and waveguide chips.

We describe a new label-free biosensor array chip developed for the real-time, simultaneous monitoring of multiple molecular binding reactions. It is composed of monolithically integrated grating couplers, microfluidic channels and spiral cavity silicon photonic wire sensors. The grating couplers use a novel design for coupling to the transverse magnetic mode of a silicon photonic wire. They contain arrays of subwavelength dimension holes, which allow the local refractive index to be engineered in the grating region. They can be fabricated with the photonic wires in a single etch step, an important advantage over other vertical couplers. The coiled waveguides are configured as ring resonators with extended cavity length for high sensitivity and small footprint for compatibility with microarray spotting. For analyte delivery, microfluidic channels were formed in an SU-8 overlayer.

We demonstrate a silicon nanowire based radio frequency spectrum analyser based on cross-phase modulation. We show that the device is accurate, with cross-chirp from photogenerated free-carriers negligible and measure RF spectra for 640Gbaud on-off-keyed data., 2010 36th European Conference and Exhibition on Optical Communication, ECOC 2010, September 19-23, 2010, Torino, Italy

Micro-photonic SOI Mach-Zehnder interferometers were coated with solid-phase micro-extraction materials derived from polydimethylsiloxane to enable sensing of volatile organic compounds of the BTEX class in air. A different coating based on functionalized mesoporous silicates is used to detect lead Pb(II) with a detection limit of < 100 ppb in water.

The gain media of the quantum dot lasers consist of InAs QDs in an InGaAsP matrix on an InP substrate. The quantum dot lasers have different free spacing ranges (FSRs) corresponding to Fabry-Perot (F-P) cavity lengths. A silicon ring resonator and a QD laser have been combined to form comb laser. The output characteristics of the combined comb laser were investigated. The measured FSR was about 2.8nm and the extinction ratio was about 10(dB) when the FSR of the QD laser was about 0.4nm and the FSR of the ring resonator was about 0.47nm. The experimental results show that the ring resonator had a strong control on the FSR and extinction ratio of the comb laser.