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2,159 results on '"Rubin, Lewis"'

1. Using a knowledge translation program to facilitate guideline‐ and evidence‐based patient management: the PAH‐QuERI Extension Program

Author

McLaughlin, Vallerie V, Channick, Richard N, Lynum, Karimah S Bell, Oudiz, Ronald J, Selej, Mona, Tapson, Victor F, and Rubin, Lewis J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Lung, Cardiovascular, educational gaps, guidelines, NYHA, WHO functional class, patient management, pulmonary arterial hypertension, NYHA/WHO functional class, Cardiorespiratory Medicine and Haematology, Cardiovascular medicine and haematology
Abstract

The Pulmonary Arterial Hypertension-Quality Enhancement Research Initiative Extension Program was designed to support physicians' adherence to pulmonary arterial hypertension (PAH) guidelines. Guidelines were followed in >95% of patients with functional class (FC) II/III, but for only 28.6% of FC IV patients (Month 36). Low adherence was driven by FC IV patients' preference to avoid parenteral treatment.

Published
2022

3. Recommendations for the Use of the Veggie Meter® for Spectroscopy-Based Skin Carotenoid Measurements in the Research Setting

Author

Radtke, Marcela D, Poe, Mykaela, Stookey, Jodi, Pitts, Stephanie Jilcott, Moran, Nancy E, Landry, Matthew J, Rubin, Lewis P, Stage, Virginia C, and Scherr, Rachel E

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, dietary assessment methodology, biomarker of nutritional status, dietary assessment, dietary intake, dietary behaviors, dietary monitoring, reflection spectroscopy, fruit and vegetable intake, Animal production, Food sciences, Nutrition and dietetics
Abstract

Carotenoids are a class of phytochemical compounds found in a variety of fruits and vegetables (F/V) and, therefore, are commonly used as a biomarker for F/V intake. The Veggie Meter® is a noninvasive research-grade instrument that detects and quantifies carotenoids in the skin. To determine current practices and examine variability among users, a survey was administered to researchers using the device (n = 19, response rate = 35.8%) and variation in anatomical site preparation, calibration, number of measurements, measurement site, and documentation was observed. A protocol was developed in partnership with Veggie Meter® users to outline the preparation, calibration, and data collection procedures for using this device for research purposes. Although many protocol conditions will benefit from additional validation, this standardized protocol supports the development of a universal data repository to establish usual observed ranges, with the ultimate goal of examining associations between skin carotenoid scores and diet-related health outcomes.

Published
2021

8. Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models

Author

Rubin, Lewis P, Ross, A Catharine, Stephensen, Charles B, Bohn, Torsten, and Tanumihardjo, Sherry A

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Complementary and Integrative Health, Prevention, Nutrition, Emerging Infectious Diseases, Aetiology, Prevention of disease and conditions, and promotion of well-being, 2.1 Biological and endogenous factors, 3.3 Nutrition and chemoprevention, Good Health and Well Being, Animals, Carotenoids, Disease Models, Animal, Dose-Response Relationship, Drug, Humans, Inflammation, Vitamin A, Vitamin A Deficiency, biomarkers, cytokines, infection, retinol, retinol-binding protein, sequestration, urinary loss, Nutrition and dietetics
Abstract

The association between inflammation and vitamin A (VA) metabolism and status assessment has been documented in multiple studies with animals and humans. The relation between inflammation and carotenoid status is less clear. Nonetheless, it is well known that carotenoids are associated with certain health benefits. Understanding these relations is key to improving health outcomes and mortality risk in infants and young children. Hyporetinolemia, i.e., low serum retinol concentrations, occurs during inflammation, and this can lead to the misdiagnosis of VA deficiency. On the other hand, inflammation causes impaired VA absorption and urinary losses that can precipitate VA deficiency in at-risk groups of children. Many epidemiologic studies have suggested that high dietary carotenoid intake and elevated plasma concentrations are correlated with a decreased risk of several chronic diseases; however, large-scale carotenoid supplementation trials have been unable to confirm the health benefits and in some cases resulted in controversial results. However, it has been documented that dietary carotenoids and retinoids play important roles in innate and acquired immunity and in the body's response to inflammation. Although animal models have been useful in investigating retinoid effects on developmental immunity, it is more challenging to tease out the effects of carotenoids because of differences in the absorption, kinetics, and metabolism between humans and animal models. The current understanding of the relations between inflammation and retinoid and carotenoid metabolism and status are the topics of this review.

Published
2017

11. Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1): Multicenter, Early Feasibility Study

Author

Rothman, Alexander M.K., Vachiery, Jean-Luc, Howard, Luke S., Mikhail, Ghada W., Lang, Irene M., Jonas, Michael, Kiely, David G., Shav, Dalit, Shabtay, Or, Avriel, Avital, Lewis, Gregory D., Rosenzweig, Erika B., Kirtane, Ajay J., Kim, Nick H., Mahmud, Ehtisham, McLaughlain, Vallerie V., Chetcuti, Stanley, Leon, Martin B., Ben-Yehuda, Ori, and Rubin, Lewis J.

Published
2020
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17. Temporary treatment interruptions with oral selexipag in pulmonary arterial hypertension: Insights from the Prostacyclin (PGI2) Receptor Agonist in Pulmonary Arterial Hypertension (GRIPHON) study

Author

Preston, Ioana R., Channick, Richard N., Chin, Kelly, Di Scala, Lilla, Farber, Harrison W., Gaine, Sean, Galiè, Nazzareno, Ghofrani, Hossein-Ardeschir, Hoeper, Marius M., Lang, Irene M., McLaughlin, Vallerie V., Preiss, Ralph, Simonneau, Gérald, Sitbon, Olivier, Tapson, Victor F., and Rubin, Lewis J.

Published
2018
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20. Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial

Author

Mehta, Sanjay, Sastry, Bhagavatula Kutumba Srinivasa, Souza, Rogério, Torbicki, Adam, Ghofrani, Hossein-Ardeschir, Channick, Richard N., Delcroix, Marion, Pulido, Tomás, Simonneau, Gérald, Wlodarczyk, John, Rubin, Lewis J., Jansa, Pavel, Hunsche, Elke, Galiè, Nazzareno, Perchenet, Loïc, and Sitbon, Olivier

Published
2017
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22. Targeting the Prostacyclin Pathway with Selexipag in Patients with Pulmonary Arterial Hypertension Receiving Double Combination Therapy: Insights from the Randomized Controlled GRIPHON Study

Author

Coghlan, J. Gerry, Channick, Richard, Chin, Kelly, Di Scala, Lilla, Galiè, Nazzareno, Ghofrani, Hossein-Ardeschir, Hoeper, Marius M., Lang, Irene M., McLaughlin, Vallerie, Preiss, Ralph, Rubin, Lewis J., Simonneau, Gérald, Sitbon, Olivier, Tapson, Victor F., and Gaine, Sean

Published
2018
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27. Initial combination therapy with ambrisentan and tadalafil and mortality in patients with pulmonary arterial hypertension: a secondary analysis of the results from the randomised, controlled AMBITION study

Author

Hoeper, Marius M, McLaughlin, Vallerie V, Barberá, Joan Albert, Frost, Adaani E, Ghofrani, Hossein-Ardeschir, Peacock, Andrew J, Simonneau, Gérald, Rosenkranz, Stephan, Oudiz, Ronald J, White, R James, Miller, Karen L, Langley, Jonathan, Harris, Julia H N, Blair, Christiana, Rubin, Lewis J, and Vachiery, Jean-Luc

Published
2016
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28. Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants

Author

Das, Abhik, McDonald, Scott A., Jobe, Alan H., Laptook, Abbot R., Oh, William, Rubin, Lewis P., Hensman, Angelita M., Fanaroff, Avroy A., Walsh, Michele C., Newman, Nancy S., Siner, Bonnie S., Donovan, Edward F., Narendran, Vivek, Alexander, Barbara, Grisby, Cathy, Hessling, Jody, Mersmann, Marcia Worley, Mincey, Holly L., Cotten, C. Michael, Auten, Kathy J., Hale, Ellen C., Wright, Linda L., Yaffe, Sumner J., McClure, Elizabeth M., Poindexter, Brenda B., Lemons, James A., Appel, Diana D., Herron, Dianne E., Wilson, Leslie D., Poole, W. Kenneth, Hastings, Betty K., Zaterka-Baxter, Kristin M., O'Donnell Auman, Jeanette, Schaefer, Scott E., Stevenson, David K., Van Meurs, Krisa P., Ball, M. Bethany, Skogstrand, Kristin, Hougaard, David M., Collins, Monica V., Cosby, Shirley S., Finer, Neil N., Rasmussen, Maynard R., Kaegi, David, Arnell, Kathy, Demetrio, Clarence, Rich, Wade, Bauer, Charles R., Duara, Shahnaz, Everett-Thomas, Ruth, Papile, Lu-Ann, Lacy, Conra Backstrom, Korones, Sheldon B., Bada, Henrietta S., Hudson, Tina, Salhab, Walid A., Madison, Susie, Kennedy, Kathleen A., Morris, Brenda H., Akpa, Esther G., Cluff, Patty A., Franco, Claudia I., Lis, Anna E., McDavid, Georgia E., Tate, Patti Pierce, O'Shea, T. Michael, Peters, Nancy J., Konduri, G. Ganesh, Bara, Rebecca, Muran, Geraldine, Gettner, Patricia, Konstantino, Monica, Poulsen, JoAnn, D'Angio, Carl T., Ambalavanan, Namasivayam, Carlo, Waldemar A., Shankaran, Seetha, Goldberg, Ronald N., Ehrenkranz, Richard A., Tyson, Jon E., Stoll, Barbara J., and Higgins, Rosemary D.

Published
2016
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29. Treprostinil Administered to Treat Pulmonary Arterial Hypertension Using a Fully Implantable Programmable Intravascular Delivery System: Results of the DelIVery for PAH Trial

Author

Bourge, Robert C., Waxman, Aaron B., Gomberg-Maitland, Mardi, Shapiro, Shelley M., Tarver, James H., III, Zwicke, Dianne L., Feldman, Jeremy P., Chakinala, Murali M., Frantz, Robert P., Torres, Fernando, Cerkvenik, Jeffrey, Morris, Marty, Thalin, Melissa, Peterson, Leigh, and Rubin, Lewis J.

Published
2016
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30. Integrating Data From Randomized Controlled Trials and Observational Studies to Assess Survival in Rare Diseases: Insights From Pulmonary Arterial Hypertension

Author

Torbicki, Adam, Bacchi, Marisa, Delcroix, Marion, Farber, Harrison W., Ghofrani, Hossein-Ardeschir, Hennessy, Brian, Jansa, Pavel, Mehta, Sanjay, Perchenet, Loïc, Pulido, Tomas, Rosenberg, Daniel, Rubin, Lewis J., Sastry, B.K.S., Simonneau, Gérald, Sitbon, Olivier, Souza, Rogério, Wei, Lee-Jen, Channick, Richard, and Benza, Raymond

Published
2019
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36. Pulmonary Hypertension: Current Management and Future Directions

Author

Rubin, Lewis J., Hofmann, Franz B., Editor-in-chief, Page, Clive P., Series editor, Rosenthal, Walter, Series editor, Michel, Martin C., Series editor, Barrett, James E., Series editor, Geppetti, Pierangelo, Series editor, Buckingham, Julia, Series editor, Moore, Philip, Series editor, Flockerzi, Veit, Series editor, Humbert, Marc, editor, Evgenov, Oleg V., editor, and Stasch, Johannes-Peter, editor

Published
2013
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40. Two formulations of epoprostenol sodium in the treatment of pulmonary arterial hypertension: EPITOME-1 (epoprostenol for injection in pulmonary arterial hypertension), a phase IV, open-label, randomized study

Author

Chin, Kelly M., Badesch, David B., Robbins, Ivan M., Tapson, Victor F., Palevsky, Harold I., Kim, Nick H., Kawut, Steven M., Frost, Adaani, Benton, Wade W., Lemarie, Jean-Christophe, Bodin, Frederic, Rubin, Lewis J., and McLaughlin, Vallerie

Published
2014
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49. The physiological basis of pulmonary arterial hypertension

Author

Naeije, Robert, Richter, Manuel Jonas, Rubin, Lewis, Naeije, Robert, Richter, Manuel Jonas, and Rubin, Lewis

Abstract

Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) failure. In spite of extensive pulmonary vascular remodelling, lung function in PAH is generally well preserved, with hyperventilation and increased physiological dead space, but minimal changes in lung mechanics and only mild to moderate hypoxaemia and hypocapnia. Hypoxaemia is mainly caused by a low mixed venous oxygen tension from a decreased cardiac output. Hypocapnia is mainly caused by an increased chemosensitivity. Exercise limitation in PAH is cardiovascular rather than ventilatory or muscular. The extent of pulmonary vascular disease in PAH is defined by multipoint pulmonary vascular pressure-flow relationships with a correction for haematocrit. Pulsatile pulmonary vascular pressure-flow relationships in PAH allow for the assessment of RV hydraulic load. This analysis is possible either in the frequency domain or in the time domain. The RV in PAH adapts to increased afterload by an increased contractility to preserve its coupling to the pulmonary circulation. When this homeometric mechanism is exhausted, the RV dilates to preserve flow output by an additional heterometric mechanism. Right heart failure is then diagnosed by imaging of increased right heart dimensions and clinical systemic congestion signs and symptoms. The coupling of the RV to the pulmonary circulation is assessed by the ratio of end-systolic to arterial elastances, but these measurements are difficult. Simplified estimates of RV-pulmonary artery coupling can be obtained by magnetic resonance or echocardiographic imaging of ejection fraction., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2022

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